start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=1
article-no=
start-page=74
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20241215
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Case series showing the safety and changes in lipid profiles of hemodialysis patients with hypertriglyceridemia after pemafibrate administration
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Cardiovascular disease is a major cause of morbidity and mortality in patients with chronic kidney disease and end-stage renal disease (ESRD). Dyslipidemia is a key focus of cardiovascular therapy and is characterized by hypertriglyceridemia mainly caused by lipoprotein lipase-mediated metabolism of ApoC-III in patients with ESRD. Pemafbrate, a selective peroxisome proliferator-activated receptor alpha modulator, can be used regardless of renal function and inhibit ApoC-III expression in the liver.<br>
Case presentation We reported the cases of four patients on hemodialysis who met at least 175 mg/dL of triglycerides on the consecutive three tests between September 2022 and November 2022 and took 0.1 mg pemafbrate twice a day from November 2022 to May 2023. They experienced no adverse events after pemafbrate treatment. Pemafbrate signifcantly reduced triglyceride (TG) (302±72 to 140±50 mg/dL, p=0.048), total cholesterol (187±34 to 156±48 mg/dL, p=0.025), and Apo C-III (15.9±8.2 to 12.6±7.1, p=0.030) levels. Apo A-II levels signifcantly increased after treatment (27.0±6.1 to 37.1±5.8, p=0.041).<br>
Conclusions Pemafbrate decreased TG, total cholesterol, and Apo-CIII and increased Apo A-II without adverse events. Further study is needed to examine the favorable efects of pemafbrate on the risk of CVD.
en-copyright=
kn-copyright=

en-aut-name=OkadaRino
en-aut-sei=Okada
en-aut-mei=Rino
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OnishiYasuhiro
en-aut-sei=Onishi
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KobayashiNaoya
en-aut-sei=Kobayashi
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiharaHiroyuki
en-aut-sei=Ishihara
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YokoyamaTomohisa
en-aut-sei=Yokoyama
en-aut-mei=Tomohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MifuneTomoyo
en-aut-sei=Mifune
en-aut-mei=Tomoyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakurabuYoshimasa
en-aut-sei=Sakurabu
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NojimaIchiro
en-aut-sei=Nojima
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MorinagaHiroshi
en-aut-sei=Morinaga
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=UchidaHaruhito A.
en-aut-sei=Uchida
en-aut-mei=Haruhito A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Okayama Saidaiji Hospital
kn-affil=

affil-num=4
en-affil=Okayama Saidaiji Hospital
kn-affil=

affil-num=5
en-affil=Okayama Saidaiji Hospital
kn-affil=

affil-num=6
en-affil=Okayama Saidaiji Hospital
kn-affil=

affil-num=7
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Hemodialysis
kn-keyword=Hemodialysis
en-keyword=Dyslipidemia
kn-keyword=Dyslipidemia
en-keyword=Apolipoprotein
kn-keyword=Apolipoprotein
en-keyword=Pemafibrate
kn-keyword=Pemafibrate
END

start-ver=1.4
cd-journal=joma
no-vol=88
cd-vols=
no-issue=10
article-no=
start-page=239
end-page=244
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=2024101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Reverse Shape Memory Effect and Toughness Recovery of Ti-10V-2Fe-3Al Alloy
kn-title=Ti-10V-2Fe-3Al合金の逆形状記憶効果と靭性回復
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ti-10V-2Fe-3Al alloys exhibit shape memory (SM) and reverse shape memory (RSM) effects. When an alloy sample that has been strained by external force at room temperature is heated, the strain recovers and SM effect develops at around 300℃, but as the temperature increases further, the shape changes in the opposite direction due to RSM effect at around 450℃. This RSM effect has potential applications in forming processes such as thin-walled pipes, but has the disadvantage that the RSM treatment makes the material very brittle. Therefore, in this study, a heat treatment to restore toughness while maintaining the shape after forming was investigated. The alloy quenched from 1050℃ had a microstructure consisting of a β matrix phase and α′′-martensite (α′′Mq). Differential scanning calorimetry (DSC) results showed that the continuous heating process occurred in the following order: α′′Mq → β reverse transformation, ω formation, ω disappearance, thermally induced α′′iso phase formation, α precipitation and α → β transformation. Ageing at 300℃, where the SM effect appears, caused significant embrittlement due to the formation of the ageing ω phase. Ageing treatment at 450℃, where the RSM effect is obtained, resulted in the formation of a fine α phase, which also caused significant embrittlement. On the other hand, additional aging at 600℃ for 1.8 ks after RSM treatment significantly improved the toughness and produced material properties comparable to aerospace material specifications. It was found that the embrittlement in the RSM treatment was due to the precipitation of fine α phase, and that the growth of α phase with a width of about 0.2 ?m or more was required for toughness recovery. It was also found that the specimen shape formed by the RSM treatment hardly changed after the additional heat treatment of 1.8 ks at 600℃.
en-copyright=
kn-copyright=

en-aut-name=TakemotoYoshito
en-aut-sei=Takemoto
en-aut-mei=Yoshito
kn-aut-name=竹元嘉利
kn-aut-sei=竹元
kn-aut-mei=嘉利
aut-affil-num=1
ORCID=

en-aut-name=ShinomiyaDaiki
en-aut-sei=Shinomiya
en-aut-mei=Daiki
kn-aut-name=四宮大輝
kn-aut-sei=四宮
kn-aut-mei=大輝
aut-affil-num=2
ORCID=

en-aut-name=IshiharaTaiki
en-aut-sei=Ishihara
en-aut-mei=Taiki
kn-aut-name=石原大暉
kn-aut-sei=石原
kn-aut-mei=大暉
aut-affil-num=3
ORCID=

en-aut-name=YokotaHiroto
en-aut-sei=Yokota
en-aut-mei=Hiroto
kn-aut-name=横田啓人
kn-aut-sei=横田
kn-aut-mei=啓人
aut-affil-num=4
ORCID=

en-aut-name=ArakawaJinta
en-aut-sei=Arakawa
en-aut-mei=Jinta
kn-aut-name=荒川仁太
kn-aut-sei=荒川
kn-aut-mei=仁太
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=岡山大学環境生命自然科学学域

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科

affil-num=3
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院環境生命自然科学研究科

affil-num=4
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院環境生命自然科学研究科

affil-num=5
en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=岡山大学環境生命自然科学学域
en-keyword=reverse shape memory
kn-keyword=reverse shape memory
en-keyword=α′′-phase
kn-keyword=α′′-phase
en-keyword=deformation induced martensite
kn-keyword=deformation induced martensite
en-keyword=β-type titanium alloy
kn-keyword=β-type titanium alloy
en-keyword=brittle fracture
kn-keyword=brittle fracture
en-keyword=toughness
kn-keyword=toughness
en-keyword=shape recovery
kn-keyword=shape recovery
en-keyword=ω-phase
kn-keyword=ω-phase
en-keyword=variant
kn-keyword=variant
END

start-ver=1.4
cd-journal=joma
no-vol=136
cd-vols=
no-issue=2
article-no=
start-page=45
end-page=47
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2023 Incentive Award of the Okayama Medical Association in Cancer Research (2023 Hayashibara Prize and Yamada Prize)
kn-title=令和５年度岡山医学会賞　がん研究奨励賞（林原賞・山田賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshinoTakamasa
en-aut-sei=Ishino
en-aut-mei=Takamasa
kn-aut-name=石野貴雅
kn-aut-sei=石野
kn-aut-mei=貴雅
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Tumor Microenvironment, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　腫瘍微小環境学
END

start-ver=1.4
cd-journal=joma
no-vol=37
cd-vols=
no-issue=2
article-no=
start-page=152
end-page=158
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Death Feigning in Larvae of Scorpionflies (Mecoptera: Panorpidae): Frequency and Postural Changes Based on Larval Instars
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Death feigning is thought to have evolved primarily as a predator avoidance behavior, and has been reported in 10 of the 31 orders of insects. However, there have been no reports of death-feigning behavior in Mecoptera species. We found that larvae of two scorpionfly species, Panorpa japonica and P. pryeri, showed death feigning in response to external stimuli by brush poking stimulation. First, we examined the frequencies of death-feigning postures. The two species showed two different postures of death feigning, “straight” and “ball.” Most of the 1st instar larvae of P. japonica and P. pryeri adopted the straight death-feigning posture. Next, we examined duration of death feigning. As the larval instar progressed, the death-feigning posture shifted from straight to ball in both Panorpa species. In P. japonica, the longest durations of death feigning were found in the 2nd to 3rd instars, while the longest duration of death feigning was found in the late 4th instar in P. pryeri larvae.
en-copyright=
kn-copyright=

en-aut-name=IshiharaRyo
en-aut-sei=Ishihara
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Anti-predator behavior
kn-keyword=Anti-predator behavior
en-keyword=freezing
kn-keyword=freezing
en-keyword=larvae
kn-keyword=larvae
en-keyword=thanatosis
kn-keyword=thanatosis
en-keyword=tonic immobility
kn-keyword=tonic immobility
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=98175
end-page=98188
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=2024
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Feasibility of Active Reactance Compensator for Autonomously Maximizing Repeater Coil Current of Wireless Power Transfer System Against Variations in Resonant Frequency and Magnetic Coupling Intensity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In resonant inductive coupling wireless power transfer systems, a repeater resonator is crucial in expanding the charging area, enabling efficient power supply to receivers, such as small Internet of Things (IoT) devices sparsely distributed in a wide area. However, the repeater current is highly susceptible to deviations in resonance frequency due to manufacturing tolerance and aging, as well as to the magnetic coupling between the transmitter and repeater coils, potentially leading to insufficient amplitude. Consequently, the magnetic field generated by the repeater decreases and the receiver may be difficult to obtain sufficient power from the transmitter via the repeater. To address this problem, this paper proposes a wireless power transfer system with active reactance compensators incorporated in the repeater and the transmitter. The proposed system can equivalently adjust the resonant frequencies of the transmitter and repeater to stably maximize the repeater coil current regardless of the variations in the resonant frequency and the magnetic coupling intensity. Experiments successfully verify that the proposed system can provide a more stable and larger repeater current and output power than the conventional system against the variations in the magnetic field intensity and the resonant frequency of the repeater, validating the feasibility of the proposed system for practical utilization of the repeater in expanding the charging area.
en-copyright=
kn-copyright=

en-aut-name=IshiharaMasataka
en-aut-sei=Ishihara
en-aut-mei=Masataka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UmetaniKazuhiro
en-aut-sei=Umetani
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KonishiAkihiro
en-aut-sei=Konishi
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HirakiEiji
en-aut-sei=Hiraki
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Faculty of Life, Environment, Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Life, Environment, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Science and Engineering, Chiba University
kn-affil=

affil-num=4
en-affil=Faculty of Life, Environment, Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Resonant inductive coupling
kn-keyword=Resonant inductive coupling
en-keyword=wireless power transfer
kn-keyword=wireless power transfer
en-keyword=repeater
kn-keyword=repeater
en-keyword=intermediate resonator
kn-keyword=intermediate resonator
en-keyword=frequency splitting phenomenon
kn-keyword=frequency splitting phenomenon
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=5
article-no=
start-page=804
end-page=810
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20249
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Augmented humoral response to third and fourth dose of SARS-CoV-2 mRNA vaccines in lung transplant recipients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Since lung transplant recipients (LTRs) exhibit low immunogenicity after two doses of SARS-CoV-2 mRNA vaccines, optimal vaccine strategies for SARS-CoV-2 are required in LTRs. This study aimed to investigate the efficacy and safety of the third and fourth doses of the SARS-CoV-2 mRNA vaccines in LTRs.<br>
Methods: We conducted a single-center study of 73 LTRs and 23 healthy controls (HCs). Participants received two-to-four doses of SARS-CoV-2 mRNA vaccines. The LTRs were divided into three groups based on the number of vaccine dose. IgG titers against SARS-CoV-2 spike protein were measured, and adverse events were assessed. Factors associated with humoral response were analyzed using univariate and multivariate analyses.<br>
Results: The Dose 4 group (n = 27) had a higher humoral response rate (P = 0.018) and higher levels of anti-SARS-CoV-2 IgG antibody (P = 0.04) than the Dose 2 group (n = 14). The Dose 3 group (n = 32) had lower humoral response rates (P = 0.005) and levels of anti-SARS-CoV-2 IgG antibody (P = 0.0005) than the HCs (n = 23) even after the same dose. Systemic adverse events were milder in the LTRs than in the HCs (P < 0.05). Increased number of vaccine dose was identified as a predictor of positive humoral response (P = 0.021).<br>
Conclusion: Booster doses of SARS-CoV-2 mRNA vaccines may enhance humoral response with mild adverse events in LTRs. Repeated vaccination might be warranted for LTRs to prevent SARS-CoV-2 infection.
en-copyright=
kn-copyright=

en-aut-name=KawanaShinichi
en-aut-sei=Kawana
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugimotoSeiichiro
en-aut-sei=Sugimoto
en-aut-mei=Seiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsubaraKei
en-aut-sei=Matsubara
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ChoshiHaruki
en-aut-sei=Choshi
en-aut-mei=Haruki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TanakaShin
en-aut-sei=Tanaka
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshiharaMegumi
en-aut-sei=Ishihara
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HabuTomohiro
en-aut-sei=Habu
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HashimotoKohei
en-aut-sei=Hashimoto
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SuzawaKen
en-aut-sei=Suzawa
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ShienKazuhiko
en-aut-sei=Shien
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MiyoshiKentaroh
en-aut-sei=Miyoshi
en-aut-mei=Kentaroh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=OkazakiMikio
en-aut-sei=Okazaki
en-aut-mei=Mikio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=NakayamaMasanori
en-aut-sei=Nakayama
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Office of Innovative Medicine, Organization for Research Strategy and Development, Okayama University
kn-affil=

affil-num=14
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Adverse events
kn-keyword=Adverse events
en-keyword=COVID-19
kn-keyword=COVID-19
en-keyword=Immunogenicity
kn-keyword=Immunogenicity
en-keyword=Lung transplantation
kn-keyword=Lung transplantation
en-keyword=mRNA vaccine
kn-keyword=mRNA vaccine
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240516
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of output factors of different radiotherapy planning systems using Exradin W2 plastic scintillator detector
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study aims to evaluate the output factors (OPF) of different radiation therapy planning systems (TPSs) using a plastic scintillator detector (PSD). The validation results for determining a practical field size for clinical use were verified. The implemented validation system was an Exradin W2 PSD. The focus was to validate the OPFs of the small irradiation fields of two modeled radiation TPSs using RayStation version 10.0.1 and Monaco version 5.51.10. The linear accelerator used for irradiation was a TrueBeam with three energies: 4, 6, and 10 MV. RayStation calculations showed that when the irradiation field size was reduced from 10?×?10 to 0.5?×?0.5 cm2, the results were within 2.0% of the measured values for all energies. Similarly, the values calculated using Monaco were within approximately 2.0% of the measured values for irradiation field sizes between 10?×?10 and 1.5?×?1.5 cm2 for all beam energies of interest. Thus, PSDs are effective validation tools for OPF calculations in TPS. A TPS modeled with the same source data has different minimum irradiation field sizes that can be calculated. These findings could aid in verification of equipment accuracy for treatment planning requiring highly accurate dose calculations and for third-party evaluation of OPF calculations for TPS.
en-copyright=
kn-copyright=

en-aut-name=AndoYasuharu
en-aut-sei=Ando
en-aut-mei=Yasuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkadaMasahiro
en-aut-sei=Okada
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsumotoNatsuko
en-aut-sei=Matsumoto
en-aut-mei=Natsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IkuhiroKawasaki
en-aut-sei=Ikuhiro
en-aut-mei=Kawasaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshiharaSoichiro
en-aut-sei=Ishihara
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KiriuHiroshi
en-aut-sei=Kiriu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TanabeYoshinori
en-aut-sei=Tanabe
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Hiroshima City Hospital
kn-affil=

affil-num=2
en-affil=Hiroshima City North Medical Center Asa Citizens Hospital
kn-affil=

affil-num=3
en-affil=Hiroshima City North Medical Center Asa Citizens Hospital
kn-affil=

affil-num=4
en-affil=Hiroshima City North Medical Center Asa Citizens Hospital
kn-affil=

affil-num=5
en-affil=Hiroshima City Hospital
kn-affil=

affil-num=6
en-affil=Hiroshima City Hospital
kn-affil=

affil-num=7
en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=Plastic scintillator
kn-keyword=Plastic scintillator
en-keyword=Radiation therapy
kn-keyword=Radiation therapy
en-keyword=Small irradiation field
kn-keyword=Small irradiation field
en-keyword=Output factor
kn-keyword=Output factor
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=5
article-no=
start-page=e1617
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202405
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Postoperative Complications in Living Donors for Lung Transplantation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background. Living donor lobar lung transplantation is a life-saving procedure for critically ill patients. This requires 2 healthy donors exposed to risks and without medical benefit. Therefore, the donor's safety and minimal postoperative complications are crucial. This study aimed to investigate the short-term outcomes and identify the risk factors affecting these outcomes. Methods. The data of 175 living donors enrolled between 1998 and 2022 were analyzed. Donors were divided into era 1 (1998-2009) and era 2 (2010-2022). Results. The overall incidence of postoperative complications was 39%, of which 7% were major complications. Donors who underwent surgery on the right side had a higher incidence of delayed pulmonary fistulae (P = 0.01) and elevated liver enzyme levels (P = 0.028). Living donor surgery on the right side (P = 0.01), era 2 (P = 0.01), and the need for plasty (P = 0.04) were predictors of postoperative complications. Conclusions. Updated data on complications and their correlation with postoperative quality of life from this study could aid in the selection of potential donors and facilitate informed consent.
en-copyright=
kn-copyright=

en-aut-name=TanakaShin
en-aut-sei=Tanaka
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujiiKento
en-aut-sei=Fujii
en-aut-mei=Kento
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshiharaMegumi
en-aut-sei=Ishihara
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ChoshiHaruki
en-aut-sei=Choshi
en-aut-mei=Haruki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsubaraKei
en-aut-sei=Matsubara
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HashimotoKohei
en-aut-sei=Hashimoto
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkaharaShuji
en-aut-sei=Okahara
en-aut-mei=Shuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShienKazuhiko
en-aut-sei=Shien
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SuzawaKen
en-aut-sei=Suzawa
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MiyoshiKentaroh
en-aut-sei=Miyoshi
en-aut-mei=Kentaroh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=YamamotoHiromasa
en-aut-sei=Yamamoto
en-aut-mei=Hiromasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=OkazakiMikio
en-aut-sei=Okazaki
en-aut-mei=Mikio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SugimotoSeiichiro
en-aut-sei=Sugimoto
en-aut-mei=Seiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Thoracic Surgery and Organ Transplant Center,  Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Anesthesiology and Resuscitology, Graduate School of  Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological  Surgery, Okayama University Graduate School of Medicine, Dentistry and  Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=201
end-page=204
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Case of Gallbladder Cancer with Trousseau Syndrome Successfully Treated Using Radical Resection
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Trousseau syndrome is characterized by cancer-associated systemic thrombosis. We describe the first case of a successfully treated gallbladder adenocarcinoma accompanied by Trousseau syndrome. A 66-year-old woman presented with right hemiplegia. Magnetic resonance imaging identified multiple cerebral infarctions. Her serum carbohydrate antigen 19-9 and D-dimer levels were markedly elevated, and a gallbladder tumor was detected via abdominal computed tomography. Venous ultrasonography of the lower limbs revealed a deep venous thrombus in the right peroneal vein. These findings suggested that the brain infarctions were likely caused by Trousseau syndrome associated with her gallbladder cancer. Radical resection of the gallbladder tumor was performed. The resected gallbladder was filled with mucus and was pathologically diagnosed as an adenocarcinoma. Her postoperative course was uneventful, and she received a one-year course of adjuvant therapy with oral S-1. No cancer recurrence or thrombosis was noted 26 months postoperatively. Despite concurrent Trousseau syndrome, a radical cure of the primary tumor and thrombosis could be achieved with the appropriate treatment.
en-copyright=
kn-copyright=

en-aut-name=MasunagaAkari
en-aut-sei=Masunaga
en-aut-mei=Akari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TabuchiMotoyasu
en-aut-sei=Tabuchi
en-aut-mei=Motoyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SakamotoShinya
en-aut-sei=Sakamoto
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YoshimatsuRika
en-aut-sei=Yoshimatsu
en-aut-mei=Rika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsumotoManabu
en-aut-sei=Matsumoto
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IwataJun
en-aut-sei=Iwata
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkabayashiTakehiro
en-aut-sei=Okabayashi
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=

affil-num=3
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=

affil-num=4
en-affil=Department of Radiology, Kochi Health Sciences Center
kn-affil=

affil-num=5
en-affil=Department of Radiology, Kochi Health Sciences Center
kn-affil=

affil-num=6
en-affil=Department of Diagnostic Pathology, Kochi Health Sciences Center
kn-affil=

affil-num=7
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=
en-keyword=gallbladder cancer
kn-keyword=gallbladder cancer
en-keyword=Trousseau syndrome
kn-keyword=Trousseau syndrome
en-keyword=radical surgery
kn-keyword=radical surgery
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=2
article-no=
start-page=e0297347
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Japan-epiretinal membrane (J-ERM) registry: A prospective cohort study protocol investigating the surgical outcome of epiretinal membrane
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background<br>
Epiretinal membrane (ERM) causes visual impairment such as reduction in visual acuity and metamorphopsia due to retinal traction. With the improvement of optical coherence tomography (OCT) and microincision vitrectomy surgery (MIVS), the surgery of ERM has significantly advanced. However, there have been no large-scale studies on the following: (1) how to evaluate visual impairment in ERM, (2) the relationship between OCT findings and visual function, (3) when is the optimal timing of surgery, and (4) the relationship between the surgical instruments as well as techniques and prognosis. The purpose of this study was to obtain evidence regarding these ERM surgeries.<br>
Methods and design<br>
This is a prospective, multicenter cohort study of ERM surgery in Japan from March 1, 2023, to March 31, 2027 (UMIN000048472, R-3468-2). Patients who underwent ERM surgery during the study period and agreed to participate in this study will be included. The goal is to have a total of 5,000 eyes surgically treated for ERM. The following data will be collected: age, gender, medical history, subjective symptoms, visual function before and 6 and 12 months after surgery, clinical findings, OCT data, surgical technique, instruments used in surgery, and complications.<br>
Discussion<br>
The results of this study will support the surgical decisions and procedures in ERM practices.
en-copyright=
kn-copyright=

en-aut-name=KanzakiYuki
en-aut-sei=Kanzaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatobaRyo
en-aut-sei=Matoba
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshiharaKenji
en-aut-sei=Ishihara
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoritaTetsuro
en-aut-sei=Morita
en-aut-mei=Tetsuro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MuraokaYuki
en-aut-sei=Muraoka
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KimuraShuhei
en-aut-sei=Kimura
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KotoTakashi
en-aut-sei=Koto
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KawasakiRyo
en-aut-sei=Kawasaki
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=BabaTakayuki
en-aut-sei=Baba
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OkamotoFumiki
en-aut-sei=Okamoto
en-aut-mei=Fumiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=InoueMakoto
en-aut-sei=Inoue
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SakamotoTaiji
en-aut-sei=Sakamoto
en-aut-mei=Taiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TsujikawaAkitaka
en-aut-sei=Tsujikawa
en-aut-mei=Akitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Kyorin Eye Center, Department of Ophthalmology, Kyorin University School of Medicine
kn-affil=

affil-num=8
en-affil=Division of Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Ophthalmology, Graduate School of Medicine, Nippon Medical School
kn-affil=

affil-num=11
en-affil=Kyorin Eye Center, Department of Ophthalmology, Kyorin University School of Medicine
kn-affil=

affil-num=12
en-affil=Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=13
en-affil=Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine
kn-affil=

affil-num=14
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=2
article-no=
start-page=240
end-page=246
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202403
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Long-term outcomes of lung transplantation requiring renal replacement therapy: A single-center experience
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background<br>
Life-long immunosuppressive therapy after lung transplantation (LT) may lead to end-stage renal disease (ESRD), requiring renal replacement therapy (RRT). We aimed to investigate the characteristics and long-term outcomes of patients undergoing LT and requiring RRT.<br>
<br>
Methods<br>
This study was a single-center, retrospective cohort study. The patients were divided into the RRT (n = 15) and non-RRT (n = 170) groups. We summarized the clinical features of patients in the RRT group and compared patient characteristics, overall survival, and chronic lung allograft dysfunction (CLAD)-free survival between the two groups.<br>
<br>
Results<br>
The cumulative incidences of ESRD requiring RRT after LT at 5, 10, and 15 years were 0.8 %, 7.6 %, and 25.2 %, respectively. In the RRT group, all 15 patients underwent hemodialysis but not peritoneal dialysis, and two patients underwent living-donor kidney transplantation. The median follow-up period was longer in the RRT group than in the non-RRT group (P < 0.001). The CLAD-free survival and overall survival did not differ between the two groups. The 5-year survival rate even after the initiation of hemodialysis was 53.3 %, and the leading cause of death in the RRT group was infection.<br>
<br>
Conclusions<br>
Favorable long-term outcomes can be achieved by RRT for ESRD after LT.
en-copyright=
kn-copyright=

en-aut-name=TomiokaYasuaki
en-aut-sei=Tomioka
en-aut-mei=Yasuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugimotoSeiichiro
en-aut-sei=Sugimoto
en-aut-mei=Seiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShiotaniToshio
en-aut-sei=Shiotani
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsubaraKei
en-aut-sei=Matsubara
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ChoshiHaruki
en-aut-sei=Choshi
en-aut-mei=Haruki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshiharaMegumi
en-aut-sei=Ishihara
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TanakaShin
en-aut-sei=Tanaka
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MiyoshiKentaroh
en-aut-sei=Miyoshi
en-aut-mei=Kentaroh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OtaniShinji
en-aut-sei=Otani
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Lung transplantation
kn-keyword=Lung transplantation
en-keyword=Dialysis
kn-keyword=Dialysis
en-keyword=Living-donor kidney transplantation
kn-keyword=Living-donor kidney transplantation
en-keyword=End -stage renal disease
kn-keyword=End -stage renal disease
en-keyword=Renal replacement therapy
kn-keyword=Renal replacement therapy
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=22028
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20231212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Bundling of collagen fibrils influences osteocyte network formation during bone modeling
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Osteocytes form a cellular network by gap junctions between their cell processes. This network is important since intercellular communication via the network is essential for bone metabolism. However, the factors that influence the formation of this osteocyte network remain unknown. As the early stage of osteocyte network formation occurs on the bone surface, we observed a newly formed trabecular bone surface by orthogonal focused ion beam-scanning electron microscopy. The embedding late osteoblast processes tended to avoid bundled collagen fibrils and elongate into sparse collagen fibrils. Then, we examined whether the inhibition of bundling of collagen fibrils using a potent lysyl oxidase inhibitor, beta-aminopropionitrile (BAPN) changed the cellular network of the chick calvaria. The osteocyte shape of the control group was spindle-shape, while that of the BAPN group was sphere-shaped. In addition, the osteocyte processes of the control group were elongated vertically to the long axis of the cell body, whereas the osteocyte processes of the BAPN group were elongated radially. Therefore, it was suggested that the bundling of collagen fibrils influences normal osteocyte network formation during bone modeling.
en-copyright=
kn-copyright=

en-aut-name=HashimotoMana
en-aut-sei=Hashimoto
en-aut-mei=Mana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakahashiHaruka
en-aut-sei=Takahashi
en-aut-mei=Haruka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Tabata-OkuboKaori
en-aut-sei=Tabata-Okubo
en-aut-mei=Kaori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NagaokaNoriyuki
en-aut-sei=Nagaoka
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TokunagaKazuaki
en-aut-sei=Tokunaga
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsumoriHaruka
en-aut-sei=Matsumori
en-aut-mei=Haruka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KakuMasaru
en-aut-sei=Kaku
en-aut-mei=Masaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IimuraTadahiro
en-aut-sei=Iimura
en-aut-mei=Tadahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HaraToru
en-aut-sei=Hara
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School
kn-affil=

affil-num=5
en-affil=Nikon Corporation
kn-affil=

affil-num=6
en-affil=Nikon Corporation
kn-affil=

affil-num=7
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Division of Bio?prosthodontics, Faculty of Dentistry and Graduate School of Medical and Dental Sciences, Niigata University
kn-affil=

affil-num=9
en-affil=Department of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University
kn-affil=

affil-num=10
en-affil=Research Center for Structural Materials, National Institute for Materials Science
kn-affil=

affil-num=11
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=
article-no=
start-page=100434
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202309
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparison of outcomes of out-of-hospital cardiac arrest patients: Emergency calls placed from mobile phones vs. landline phones
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Until recently, calls to the emergency medical service (EMS) from landline phones, which display the caller’s exact location at the dispatch center, had been common. Since the use of mobile phones has become widespread, many emergency calls are now made from mobile phones. Differences in outcomes of out-of-hospital cardiac arrest (OHCA) patients for whom EMS was called from mobile versus landline phones has not yet been fully elucidated.<br>
Methods: We performed a retrospective, population-based analysis in Kobe, Japan to examine whether EMS calls from mobiles improved the prognosis of OHCA patients over EMS calls placed from landlines. The primary outcome was favorable neurological outcome, defined as Cerebral Performance Category (CPC) scores of 1 or 2 at discharge. Secondary outcomes were survival at one-month, survival at discharge, and time durations between call and EMS activities.<br>
Results: Of 4,231 OHCA cases, 2,194 cases (706 landline cases vs. 1,488 mobile cases) were included in this study. The percentages of favorable neurological outcomes were 0.7% (5/706) in the landline group and 3.8% (56/1,488) in the mobile group. Adjusted multivariable logistic regression revealed that favorable neurological outcomes (odds ratio [OR] 3.03, 95% confidence interval [CI] 1.12?8.17, p = 0.03) were better in the mobile group, while one-month survival (OR 1.30, 95% CI 0.80?2.14, p = 0.29) was not significantly different. Bystander CPR was more frequently administered in the mobile group (landlines 61.3% vs. mobiles 68.4%, p < 0.01). Time durations between call to EMS dispatch (184.5 [IQR 157?220 s] vs. 205 [IQR 174?248 s], p < 0.01) and EMS arrival (476.5 [IQR 377?599 s] vs. 491 [IQR 407.5?611.5 s], p < 0.01) were shorter in the landline group.<br>
Conclusions: Although the landline caller location display system seems effective for shorter times between EMS call and EMS arrival, mobile phone use was associated with better neurological outcomes.
en-copyright=
kn-copyright=

en-aut-name=NishimuraTakeshi
en-aut-sei=Nishimura
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugaMasafumi
en-aut-sei=Suga
en-aut-mei=Masafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HongoTakashi
en-aut-sei=Hongo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YumotoTetsuya
en-aut-sei=Yumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshiharaSatoshi
en-aut-sei=Ishihara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center
kn-affil=

affil-num=7
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Cardiac arrest
kn-keyword=Cardiac arrest
en-keyword=OHCA
kn-keyword=OHCA
en-keyword=CPR
kn-keyword=CPR
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=生体肺移植後の長期的なドナーQOLの検討
kn-title=Donor’s long-term quality of life following living-donor lobar lung transplantation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FUJIIKento
en-aut-sei=FUJII
en-aut-mei=Kento
kn-aut-name=藤井健人
kn-aut-sei=藤井
kn-aut-mei=健人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=4
article-no=
start-page=273
end-page=278
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220720
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Acute sensorineural hearing loss after using a privately imported PDE-5 inhibitor : A case report
kn-title=個人輸入した PDE-5 阻害薬の内服後に生じた急性感音難聴の 1 例
en-subtitle=
kn-subtitle=
en-abstract=We herein report a case of acute sensory deafness that occurred immediately after taking a privately imported phosphodiesterase-5 inhibitor. A man in his 40s developed sensorineural hearing loss after using vardenafil purchased over the Internet. He received systemic prednisolone and discontinued vardenafil, which generally improved his hearing. Although it has been pointed out that phosphodiesterase-5 inhibitors are associated with deafness, this fact is not well known in Japan. It is easy to import phosphodiesterase-5 inhibitor for personal use via the Internet. However, many counterfeit drugs of phosphodiesterase-5 inhibitor are distributed online, causing health hazards. We should always be alert for any medications that need to be discontinued.
kn-abstract=個人輸入した PDE-5 阻害薬内服後に急性感音難聴を生じた症例を経験したため報告する。症例は 40 代、男性。インターネット経由で購入したバルデナフィルを使用後に、感音難聴を生じた。プレドニゾロンの全身投与を行い、バルデナフィルを中止したところ、聴力はおおむね改善した。PDE-5 阻害薬は難聴との関連が指摘されているが、わが国では十分に周知されていない。PDE-5 阻害薬はインターネットで簡単に個人輸入できる一方で、偽造薬も数多く出回っており、健康被害も生じている。また、個人輸入薬は処方薬に比して服薬歴の把握が難しい場合があり、薬剤性難聴を疑う場合は詳細な問診を心掛ける必要がある。
en-copyright=
kn-copyright=

en-aut-name=KARIYAAkifumi
en-aut-sei=KARIYA
en-aut-mei=Akifumi
kn-aut-name=假谷彰文
kn-aut-sei=假谷
kn-aut-mei=彰文
aut-affil-num=1
ORCID=

en-aut-name=ISHIHARAHisashi
en-aut-sei=ISHIHARA
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=2
ORCID=

en-aut-name=AKISADANaoki
en-aut-sei=AKISADA
en-aut-mei=Naoki
kn-aut-name=秋定直樹
kn-aut-sei=秋定
kn-aut-mei=直樹
aut-affil-num=3
ORCID=

en-aut-name=HAMADAKoji
en-aut-sei=HAMADA
en-aut-mei=Koji
kn-aut-name=濱田浩司
kn-aut-sei=濱田
kn-aut-mei=浩司
aut-affil-num=4
ORCID=

en-aut-name=FUJISayaka
en-aut-sei=FUJI
en-aut-mei=Sayaka
kn-aut-name=藤さやか
kn-aut-sei=藤
kn-aut-mei=さやか
aut-affil-num=5
ORCID=

en-aut-name=AKAGISeiko
en-aut-sei=AKAGI
en-aut-mei=Seiko
kn-aut-name=赤木成子
kn-aut-sei=赤木
kn-aut-mei=成子
aut-affil-num=6
ORCID=

en-aut-name=TAKEUCHIAyako
en-aut-sei=TAKEUCHI
en-aut-mei=Ayako
kn-aut-name=竹内彩子
kn-aut-sei=竹内
kn-aut-mei=彩子
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=2
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=3
en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科耳鼻咽喉・頭頸部外科学

affil-num=4
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=5
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=6
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=7
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科
en-keyword=急性感音難聴
kn-keyword=急性感音難聴
en-keyword=薬剤性難聴
kn-keyword=薬剤性難聴
en-keyword=PDE-5 阻害薬
kn-keyword=PDE-5 阻害薬
en-keyword=バルデナフィル
kn-keyword=バルデナフィル
en-keyword=個人輸入薬
kn-keyword=個人輸入薬
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=9
article-no=
start-page=5182
end-page=5194
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230627
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Long-term management and outcome of lung transplantation in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The long-term survival after lung transplantation (LT) is favorable in Japan. However, longterm survivors after LT are subject to late complications, including chronic lung allograft dysfunction (CLAD), malignancy, infection, and chronic kidney disease (CKD) because of the need for lifelong immunosuppression. The rates of single cadaveric LT (CLT) and living-donor lobar LT (LDLLT) are higher than that of bilateral CLT in Japan. Here, we will describe the management of late complications and long-term outcome after LT in Japan. Attention should be paid to not only the phenotype of CLAD but also the difference in CLAD after CLT and after LDLLT as well as the timing of lung re-transplantation for advanced CLAD, especially after single CLT. Since post-transplant lymphoproliferative disorder is the most common malignancy after LT, infection monitoring for infection-related malignancies and appropriate screening are keys to the early diagnosis and treatment of malignancy after LT. The long-term management of infection after LT is also important, especially with regard to community-acquired pathogens, Aspergillus, and cytomegalovirus. When providing long-term care after LT, physicians should be aware of CKD and the timing of renal replacement therapy in cases with severe CKD. The widespread use of computed tomography and dialysis in Japan are beneficial for long-term survivors of LT. The similar survival outcomes of single CLT and LDLLT, compared with bilateral CLT, might contribute to improved long-term survival in Japan. Pulmonologists are encouraged to become further involved in long-term management after LT in Japan.
en-copyright=
kn-copyright=

en-aut-name=SugimotoSeiichiro
en-aut-sei=Sugimoto
en-aut-mei=Seiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsubaraKei
en-aut-sei=Matsubara
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaShin
en-aut-sei=Tanaka
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyoshiKentaroh
en-aut-sei=Miyoshi
en-aut-mei=Kentaroh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshiharaMegumi
en-aut-sei=Ishihara
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
kn-affil=
en-keyword=Lung transplantation
kn-keyword=Lung transplantation
en-keyword=chronic lung allograft dysfunction
kn-keyword=chronic lung allograft dysfunction
en-keyword=infection
kn-keyword=infection
en-keyword=malignan
kn-keyword=malignan
en-keyword=cychronic kidney
kn-keyword=cychronic kidney
en-keyword=disease
kn-keyword=disease
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=3
article-no=
start-page=281
end-page=290
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Impact of Immediate Breast Reconstruction on Survival of Breast Cancer Patients: A Single-Center Observational Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although immediate breast reconstruction following mastectomy has become increasingly common, its oncological safety has been debated. We enrolled patients with breast cancer who underwent surgery at Okayama University Hospital between 2007 and 2013. The primary outcome was relapse-free survival (RFS). Secondary outcomes were overall survival and the duration from the surgery to the initiation of adjuvant chemotherapy. We divided into immediate breast reconstruction, mastectomy alone, and breast conservative surgery groups. Outcomes were compared using Cox’s regression analysis. A total of 614 patients were included (reconstruction: 125, mastectomy: 128, breast conservative surgery: 361). The median follow-up duration was 79.0±31.9 months. The immediate-reconstruction patients were younger, had more lymph node metastases, and more often received postoperative chemotherapy. The RFS was better after the breast conservative surgery compared to after reconstruction (hazard ratio 0.33, 95% confidence interval: 0.144-0.763). The proportion of local recurrence was highest in the reconstruction group. No patients in the reconstruction group underwent postoperative radiation therapy. However, reconstruction did not affect overall survival or the time to the initiation of adjuvant chemotherapy. Surgeons should explain the risks of breast reconstruction to their patients preoperatively. Careful long-term follow-up is required after such procedures.
en-copyright=
kn-copyright=

en-aut-name=MukaiYuko
en-aut-sei=Mukai
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TairaNaruto
en-aut-sei=Taira
en-aut-mei=Naruto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KajiwaraYukiko
en-aut-sei=Kajiwara
en-aut-mei=Yukiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IwamotoTakayuki
en-aut-sei=Iwamoto
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KitaguchiYohei
en-aut-sei=Kitaguchi
en-aut-mei=Yohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SaigaMiho
en-aut-sei=Saiga
en-aut-mei=Miho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=WatanabeSatoko
en-aut-sei=Watanabe
en-aut-mei=Satoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShienTadahiko
en-aut-sei=Shien
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=DoiharaHiroyoshi
en-aut-sei=Doihara
en-aut-mei=Hiroyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KimataYoshihiro
en-aut-sei=Kimata
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Breast and Thyroid Surgery, Kawasaki Medical School Hospital
kn-affil=

affil-num=3
en-affil=Department of Breast Surgery, Hiroshima Citizens Hospital
kn-affil=

affil-num=4
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=immediate breast reconstruction
kn-keyword=immediate breast reconstruction
en-keyword=oncological safety
kn-keyword=oncological safety
en-keyword=local recurrence
kn-keyword=local recurrence
en-keyword=postoperative radiation therapy
kn-keyword=postoperative radiation therapy
en-keyword=time to initiation of adjuvant chemotherapy
kn-keyword=time to initiation of adjuvant chemotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=5433
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230403
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Impact of frailty on long-term mortality in older patients receiving intensive care via the emergency department
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study was to evaluate whether frailty was associated with 6-month mortality in older adults who were admitted to the intensive care unit (ICU) with an illness requiring emergency care. The investigation was a prospective, multi-center, observational study conducted among the ICUs of 17 participating hospitals. Patients >= 65 years of age who were admitted to the ICU directly from an emergency department visit were assessed to determine their baseline Clinical Frailty Scale (CFS) scores before the illness and were surveyed 6 months after admission. Among 650 patients included in the study, the median age was 79 years old, and overall mortality at 6 months was as low as 21%, ranging from 6.2% in patients with CFS 1 to 42.9% in patients with CFS >= 7. When adjusted for potential confounders, CFS score was an independent prognostic factor for mortality (one-point increase in CFS, adjusted risk ratio with 95% confidence interval 1.19 [1.09-1.30]). Quality of life 6 months after admission worsened as baseline CFS score increased. However, there was no association between total hospitalization cost and baseline CFS. CFS is an important predictor of long-term outcomes among critically ill older patients requiring emergent admission.
en-copyright=
kn-copyright=

en-aut-name=InabaMototaka
en-aut-sei=Inaba
en-aut-mei=Mototaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakamichiChikaaki
en-aut-sei=Nakamichi
en-aut-mei=Chikaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MaeyamaHiroki
en-aut-sei=Maeyama
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshikawaHideki
en-aut-sei=Ishikawa
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShimeNobuaki
en-aut-sei=Shime
en-aut-mei=Nobuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=UemoriSadayori
en-aut-sei=Uemori
en-aut-mei=Sadayori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IshiharaSatoshi
en-aut-sei=Ishihara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TakaokaMakoto
en-aut-sei=Takaoka
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OhtsukaTsuyoshi
en-aut-sei=Ohtsuka
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HaradaMasahiro
en-aut-sei=Harada
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=NozakiSatoshi
en-aut-sei=Nozaki
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KohamaKeisuke
en-aut-sei=Kohama
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=SakuraiRyota
en-aut-sei=Sakurai
en-aut-mei=Ryota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=SatoShuho
en-aut-sei=Sato
en-aut-mei=Shuho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=MuramatsuShun
en-aut-sei=Muramatsu
en-aut-mei=Shun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=YamashitaKazunori
en-aut-sei=Yamashita
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=MayumiToshihiko
en-aut-sei=Mayumi
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=AitaKaoruko
en-aut-sei=Aita
en-aut-mei=Kaoruko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=the LIFE Study Investigators
en-aut-sei=the LIFE Study Investigators
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Advanced Emergency and Critical Care Center, National Hospital Organization, Nagasaki Medical Center
kn-affil=

affil-num=5
en-affil=Emergency and Critical Care Center, Tsuyama Chuo Hospital
kn-affil=

affil-num=6
en-affil=Trauma and Resuscitation Center, Teikyo University Hospital
kn-affil=

affil-num=7
en-affil=Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
kn-affil=

affil-num=8
en-affil=Department of Emergency, Yodogawa Christian Hospital
kn-affil=

affil-num=9
en-affil=Department of Emergency and Critical Care, Hyogo Emergency Medical Center
kn-affil=

affil-num=10
en-affil=Acute Care Division, Harima-Himeji General Medical Center
kn-affil=

affil-num=11
en-affil=Emergency Department, National Hospital Organization Yokohama Medical Center
kn-affil=

affil-num=12
en-affil=Department of Emergency and Critical Care, National Hospital Organization Kumamoto Medical Center
kn-affil=

affil-num=13
en-affil=Emergency Department, Okayama Saiseikai General Hospital
kn-affil=

affil-num=14
en-affil=Department of Emergency, Disaster, and Critical Care Medicine, Hyogo College of Medicine
kn-affil=

affil-num=15
en-affil=Department of Emergency and Critical Care Medicine, Faculty of Medicine, Saga University
kn-affil=

affil-num=16
en-affil=Emergency Medical Center, Saiseikai Senri Hospital
kn-affil=

affil-num=17
en-affil=Emergency Department, Japanese Red Cross Medical Center
kn-affil=

affil-num=18
en-affil=Acute and Critical Care Center, Nagasaki University Hospital
kn-affil=

affil-num=19
en-affil=Department of Emergency Medicine, University of Occupational and Environmental Health Hospital
kn-affil=

affil-num=20
en-affil=Uehiro Division, Center for Death and Life Studies and Practical Ethics, Graduate School of Humanities and Sociology, University of Tokyo
kn-affil=

affil-num=21
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=22
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=肥満・高脂血症は相乗的に乾癬様皮疹を悪化させる
kn-title=Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IKEDAKenta
en-aut-sei=IKEDA
en-aut-mei=Kenta
kn-aut-name=池田賢太
kn-aut-sei=池田
kn-aut-mei=賢太
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=2
article-no=
start-page=209
end-page=213
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Locally Advanced Rectal Cancer Invading the Gluteus Maximus Muscle Completely Responded to Total Neoadjuvant Therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival.
en-copyright=
kn-copyright=

en-aut-name=SakamotoMasaki
en-aut-sei=Sakamoto
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TeraishiFuminori
en-aut-sei=Teraishi
en-aut-mei=Fuminori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=ShigeyasuKunitoshi
kn-aut-sei=Shigeyasu
kn-aut-mei=Kunitoshi
aut-affil-num=3
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=locally advanced rectal cancer
kn-keyword=locally advanced rectal cancer
en-keyword=total neoadjuvant therapy
kn-keyword=total neoadjuvant therapy
en-keyword=lateral vastus lateral great muscle flap
kn-keyword=lateral vastus lateral great muscle flap
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=1
article-no=
start-page=e829
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Influence of coronavirus disease 2019 case surges on prehospital emergency medical service for patients with trauma in Kobe, Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aim: In the current era of the coronavirus disease 2019 (COVID-19) pandemic, the responsiveness of emergency medical service (EMS) transport for patients with internal illness is often delayed. However, the influence of the COVID-19 pandemic on prehospital transport for patients with trauma has not yet been fully elucidated. This study aims to examine the effect of COVID-19 case surges on EMS transport for patients with trauma during the COVID-19 states of emergency in Kobe, Japan. <br>
Methods: EMS data during the states of emergency were compared with those in the 2019 prepandemic period. The incidence of difficulty securing hospital acceptance (four or more calls to medical institutions and ambulance staying at the scene for 30 min or more) was evaluated as a primary outcome. Secondary outcomes were the time spent at the trauma scene and the number of calls requesting hospital acceptance. The time spent at the trauma scene was stratified by trauma severity. <br>
Results: The incidence of difficulty securing hospital acceptance increased (1.2% versus 3.2%, P < 0.01). Logistic regression analysis revealed that the duration of the states of emergency was associated with difficulty securing hospital acceptance (odds ratio [OR] 2.08, 95% confidence interval 1.77-2.45; P < 0.01). Although the mean time spent at the trauma scene among the less severe, moderately severe, and severe trauma groups was prolonged, the time for the life-threatening group did not change. The number of request calls increased during the states of emergency. <br>
Conclusion: Difficulty securing hospital acceptance increased; however, the time spent at the trauma scene did not significantly change for the life-threatening group.
en-copyright=
kn-copyright=

en-aut-name=NishimuraTakeshi
en-aut-sei=Nishimura
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugaMasafumi
en-aut-sei=Suga
en-aut-mei=Masafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshiharaSatoshi
en-aut-sei=Ishihara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakayamaShinichi
en-aut-sei=Nakayama
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center
kn-affil=

affil-num=4
en-affil=Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center
kn-affil=

affil-num=5
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Coronavirus
kn-keyword=Coronavirus
en-keyword=EMS
kn-keyword=EMS
en-keyword=prehospital time
kn-keyword=prehospital time
en-keyword=severity
kn-keyword=severity
en-keyword=state of emergency
kn-keyword=state of emergency
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background<br>
Identifying biomarkers to predict immune checkpoint inhibitor (ICI) efficacy is warranted. Considering that somatic mutation-derived neoantigens induce strong immune responses, patients with a high tumour mutational burden reportedly tend to respond to ICIs. However, there are several conflicting data. Therefore, we focused on the original function of neoantigenic mutations and their impact on the tumour microenvironment (TME).<br>
<br>
Methods<br>
We evaluated 88 high-frequency microsatellite instability (MSI-H) colorectal cancers and analysed the function of the identified neoantigenic mutations and their influence on programmed cell death 1 (PD-1) blockade efficacy. The results were validated using The Cancer Genome Atlas (TCGA) datasets.<br>
<br>
Results<br>
We identified frameshift mutations in RNF43 as a common neoantigenic gene mutation in MSI-H tumours. However, loss-of-function RNF43 mutations induced noninflamed TME by activating the WNT/β-catenin signalling pathway. In addition, loss of RNF43 function induced resistance to PD-1 blockade even in neoantigen-rich tumours. TCGA dataset analyses demonstrated that passenger rather than driver gene mutations were related to the inflamed TME in diverse cancer types.<br>
<br>
Conclusions<br>
We propose a novel concept of “paradoxical neoantigenic mutations” that can induce noninflamed TME through their original gene functions, despite deriving neoantigens, suggesting the significance of qualities as well as quantities in neoantigenic mutations.
en-copyright=
kn-copyright=

en-aut-name=IshinoTakamasa
en-aut-sei=Ishino
en-aut-mei=Takamasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawashimaShusuke
en-aut-sei=Kawashima
en-aut-mei=Shusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanjiEtsuko
en-aut-sei=Tanji
en-aut-mei=Etsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UenoToshihide
en-aut-sei=Ueno
en-aut-mei=Toshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=UedaYouki
en-aut-sei=Ueda
en-aut-mei=Youki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OgasawaraSadahisa
en-aut-sei=Ogasawara
en-aut-mei=Sadahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SatoKazuhito
en-aut-sei=Sato
en-aut-mei=Kazuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ManoHiroyuki
en-aut-sei=Mano
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IshiharaSoichiro
en-aut-sei=Ishihara
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KatoNaoya
en-aut-sei=Kato
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KawazuMasahito
en-aut-sei=Kawazu
en-aut-mei=Masahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TogashiYosuke
en-aut-sei=Togashi
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=3
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=4
en-affil=Division of Cellular Signaling, National Cancer Center Research Institute
kn-affil=

affil-num=5
en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=7
en-affil=Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=8
en-affil=Division of Cellular Signaling, National Cancer Center Research Institute
kn-affil=

affil-num=9
en-affil=Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=11
en-affil=Division of Cell Therapy, Chiba Cancer Center Research Institute
kn-affil=

affil-num=12
en-affil=Department of Tumor Microenvironment, Okayama University, Graduate School of Medicine Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=1
article-no=
start-page=75
end-page=80
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202302
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Scattered Tiny Whitish Protrusions in the Stomach Are a Clue to the Diagnosis of Autoimmune Gastritis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Herein, we report two patients with autoimmune gastritis who had undergone multiple esophagogastroduodenoscopy procedures for 17 and 9 years, respectively, before their diagnosis. Instead, they had been diagnosed with and treated for Helicobacter pylori-associated gastritis. The correct diagnosis was made when scatterings of tiny whitish protrusions in the gastric mucosa were detected on esophagogastroduodenoscopy. Our findings suggest that scattered tiny whitish bumps may be a clue to the diagnosis of autoimmune gastritis.
en-copyright=
kn-copyright=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HamadaKenta
en-aut-sei=Hamada
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KonoYoshiyasu
en-aut-sei=Kono
en-aut-mei=Yoshiyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KanzakiHiromitsu
en-aut-sei=Kanzaki
en-aut-mei=Hiromitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KawanoSeiji
en-aut-sei=Kawano
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawaharaYoshiro
en-aut-sei=Kawahara
en-aut-mei=Yoshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=autoimmune gastritis
kn-keyword=autoimmune gastritis
en-keyword=esophagogastroduodenoscopy
kn-keyword=esophagogastroduodenoscopy
en-keyword=scattered lesions
kn-keyword=scattered lesions
en-keyword=small white protrusions
kn-keyword=small white protrusions
en-keyword=mucosal lesions
kn-keyword=mucosal lesions
END

start-ver=1.4
cd-journal=joma
no-vol=67
cd-vols=
no-issue=6
article-no=
start-page=402
end-page=406
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211120
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Idiopathic first bite syndrome improved by Rikkosan : A case report
kn-title=立効散が有効であった特発性ファーストバイト症候群の1例
en-subtitle=
kn-subtitle=
en-abstract=First bite syndrome (FBS) is characterized by severe paroxysmal pain in the parotid region at the first bite of a meal, which gradually decreases as mastication continues. When FBS occurs with no history of head and neck surgery and no evidence of a tumor, it is classified as idiopathic. The effectiveness of Rikkosan has been reported by several studies, and we also experienced a case in which idiopathic FBS improved with Rikkosan. There is no established treatment method for idiopathic FBS. Rikkosan, which is associated with few adverse events, should be considered as a first-line treatment, along with diet therapy.
kn-abstract=ファーストバイト症候群（first bite syndrome：以下、FBS）は、食事開始時に耳下腺部痛を生じ数回の咀嚼により徐々に軽快することを特徴とする。手術既往や腫瘍性疾患がない FBS は特発性 FBS と分類される。特発性 FBS に対する治療法として少数ではあるが立効散の内服が報告されており、本症例でも立効散が奏功した。特発性 FBS の治療法は未確立であり、有害事象の少ない立効散は食事療法と並んでまず考慮すべき治療法であると考える。
en-copyright=
kn-copyright=

en-aut-name=SatoAsuka
en-aut-sei=Sato
en-aut-mei=Asuka
kn-aut-name=佐藤明日香
kn-aut-sei=佐藤
kn-aut-mei=明日香
aut-affil-num=1
ORCID=

en-aut-name=IshiharaHisashi
en-aut-sei=Ishihara
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=2
ORCID=

en-aut-name=KariyaAkifumi
en-aut-sei=Kariya
en-aut-mei=Akifumi
kn-aut-name=假谷彰文
kn-aut-sei=假谷
kn-aut-mei=彰文
aut-affil-num=3
ORCID=

en-aut-name=AkisadaNaoki
en-aut-sei=Akisada
en-aut-mei=Naoki
kn-aut-name=秋定直樹
kn-aut-sei=秋定
kn-aut-mei=直樹
aut-affil-num=4
ORCID=

en-aut-name=FujiSayaka
en-aut-sei=Fuji
en-aut-mei=Sayaka
kn-aut-name=藤さやか
kn-aut-sei=藤
kn-aut-mei=さやか
aut-affil-num=5
ORCID=

en-aut-name=AkagiSeiko
en-aut-sei=Akagi
en-aut-mei=Seiko
kn-aut-name=赤木成子
kn-aut-sei=赤木
kn-aut-mei=成子
aut-affil-num=6
ORCID=

en-aut-name=TakeuchiAyako
en-aut-sei=Takeuchi
en-aut-mei=Ayako
kn-aut-name=竹内彩子
kn-aut-sei=竹内
kn-aut-mei=彩子
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=2
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=3
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=4
en-affil=Department of Otolaryngology, Head and Neck Surgery, Okayama University Postgraduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=岡山大学大学院医歯薬学総合研究科耳鼻咽喉・頭頸部外科

affil-num=5
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=6
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=7
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科
en-keyword=First bite syndrome, 
kn-keyword=First bite syndrome, 
en-keyword=立効散
kn-keyword=立効散
en-keyword=耳下腺部痛
kn-keyword=耳下腺部痛
en-keyword=顔面痛
kn-keyword=顔面痛
en-keyword=糖尿病性神経障害
kn-keyword=糖尿病性神経障害
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=6
article-no=
start-page=679
end-page=688
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Efficacy and Safety of Three-dimensional Conformal Radiotherapy for Macroscopic Vascular Invasion of Hepatocellular Carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Chemotherapy is insufficient to treat macroscopic vascular invasion (MVI) of hepatocellular carcinoma (HCC). We retrospectively investigated the treatment outcomes of patients who underwent three-dimensional conformal radiotherapy (3D-CRT) for HCC MVI and analyzed prognostic factors by multivariate analysis using a Cox proportional hazard model. Sixty-five patients were studied. MVI sites were the portal vein (n=48 patients), portal and hepatic veins (n=8), and hepatic vein (n=9). The median irradiation dose was 50 Gy. The median survival time (MST) was 7.5 months. Performance status 2 or 3, modified albumin-bilirubin grade 2b or 3, and massive/diffuse type were poor prognostic factors. Nineteen patients (29%) with a treatment effect of 3 or 4 (? 50% of tumor necrosis or regression) at the irradiation sites according to the Response Evaluation Criteria in Cancer of the Liver showed longer survival than those with an effect of 1 or 2 (MST 18.7 vs. 5.9 months, p<0.001). No treatment-related death occurred. The hepatic function reserve was preserved in more than 70% of patients. 3D-CRT controlled HCC MVI safely and was suggested to be a good treatment option.
en-copyright=
kn-copyright=

en-aut-name=AsagiAkinori
en-aut-sei=Asagi
en-aut-mei=Akinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakaguchiChihiro
en-aut-sei=Sakaguchi
en-aut-mei=Chihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NadanoSeijin
en-aut-sei=Nadano
en-aut-mei=Seijin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NishinaTomohiro
en-aut-sei=Nishina
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HamamotoYasushi
en-aut-sei=Hamamoto
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KataokaMasaaki
en-aut-sei=Kataoka
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamashitaNatsumi
en-aut-sei=Yamashita
en-aut-mei=Natsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TanimizuMasahito
en-aut-sei=Tanimizu
en-aut-mei=Masahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HyodoIchinosuke
en-aut-sei=Hyodo
en-aut-mei=Ichinosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=2
en-affil=Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=3
en-affil=Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=4
en-affil=Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=5
en-affil=Department of Radiation Oncology, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=6
en-affil=Department of Radiology, Saiseikai Imabari Hospital
kn-affil=

affil-num=7
en-affil=Department of Clinical Research Center, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=8
en-affil=Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=9
en-affil=Department of Gastrointestinal Medical Oncology, National Hospital Organization Shikoku Cancer Center
kn-affil=
en-keyword=hepatocellular carcinoma
kn-keyword=hepatocellular carcinoma
en-keyword=macroscopic vascular invasion
kn-keyword=macroscopic vascular invasion
en-keyword=portal vein tumor thrombosis
kn-keyword=portal vein tumor thrombosis
en-keyword=hepatic vein tumor thrombosis
kn-keyword=hepatic vein tumor thrombosis
en-keyword=three-dimensional conformal radiotherapy
kn-keyword=three-dimensional conformal radiotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=40
article-no=
start-page=e30857
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20221007
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Bilateral verses bilateral with tri-segmental endoscopic drainage using metal stents for high-grade malignant hilar biliary obstructions: A multicenter, randomized controlled trial: BRAVE study (BRAVE study)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Introduction: Bilateral endoscopic drainage with self-expanding metallic stent (SEMS) can be used to manage hilar malignant biliary obstruction (HMBO) more effectively in comparison to unilateral drainage. An increased drainage area is predicted to prolong stent patency and patient survival. However, few reports have described the utility of trisegmental drainage and the benefits of using trisegmental drainage remain unknown. Thus, we launched a randomized clinical trial (RCT) to compare the clinical outcomes between bilateral and trisegmental drainage using SEMSs in patients with high-grade HMBO. Methods and analysis: This study was conducted as a multicenter randomized control trial (RCT) in 8 high-volume medical centers in Japan, and will prove the non-inferiority of bilateral drainage to trisegmental drainage. Patients with unresectable HMBO with Bismuth type IIIa or IV who pass the inclusion and exclusion criteria will be randomized to receive bilateral or trisegmental drainage at a 1:1 ratio. At each center, the on-site study investigators will obtain informed consent from the candidates, and will use an electronic data capture system (REDCap) to input necessary information, and register candidates with the registration secretariat. The primary endpoint is the rate of non-recurrent biliary obstruction (RBO) at 180 days after SEMSs placement. A -10% non-inferiority margin is assumed in the statistical analysis of the primary endpoint. Secondary endpoints include the rate of technical and clinical success, time to recurrent biliary obstruction (TRBO), causes of RBO, procedure-related adverse events (AEs), procedure time, TRBO with or without endoscopic sphincterotomy, overall survival, and the technical and clinical success rates at reintervention. Discussion: If the non-inferiority of bilateral drainage is demonstrated, it is predicted that the procedure time will be shortened and the medical cost will be reduced, which will be beneficial to the patient and the medical economy.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoKazuyuki
en-aut-sei=Matsumoto
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KawamotoHirofumi
en-aut-sei=Kawamoto
en-aut-mei=Hirofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshidaEtsuji
en-aut-sei=Ishida
en-aut-mei=Etsuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiiMasakuni
en-aut-sei=Fujii
en-aut-mei=Masakuni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AkimotoYutaka
en-aut-sei=Akimoto
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SekiHiroyuki
en-aut-sei=Seki
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshiharaYuki
en-aut-sei=Ishihara
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OgawaTaiji
en-aut-sei=Ogawa
en-aut-mei=Taiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamazakiTatsuhiro
en-aut-sei=Yamazaki
en-aut-mei=Tatsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=FujiiYuki
en-aut-sei=Fujii
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Center for Innovative Clinical Medicine, Okayama University  Hospital
kn-affil=

affil-num=3
en-affil=Department of General Internal Medicine 2,  Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology  and Hepatology, Kurashiki Central Hospital
kn-affil=

affil-num=5
en-affil=Department  of Internal Medicine, Okayama Saiseikai General Hospital
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology, Japanese Red Cross Okayama Hospital
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology, Mitoyo General Hospital
kn-affil=

affil-num=8
en-affil= Department of Gastroenterology, Iwakuni Medical Center
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology, Tsuyama Central Hospital
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology and Hepatology, Okayama University Hospital
kn-affil=
en-keyword=bilateral drainage
kn-keyword=bilateral drainage
en-keyword=bile duct obstruction
kn-keyword=bile duct obstruction
en-keyword=endoscopic biliary drainage
kn-keyword=endoscopic biliary drainage
en-keyword=neoplasms
kn-keyword=neoplasms
en-keyword=self-expandable metallic stents
kn-keyword=self-expandable metallic stents
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=1
article-no=
start-page=e786
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220916
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Prehospital advanced airway management of emergency medical service-witnessed traumatic out-of-hospital cardiac arrest patients: analysis of nationwide trauma registry
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aim: Survival of traumatic out-of-hospital cardiac arrest (OHCA) is poor. Early use of advanced airway management (AAM) tech niques, including endotracheal intubation and supraglottic devices, are expected to contribute to the improved survival of these patients. The aim of this study was to determine whether prehospital use of AAM improves the outcomes for emergency medical service (EMS)-witnessed traumatic OHCA. Methods: A nationwide retrospective study was carried out. Trauma patients with EMS-witnessed cardiac arrest who received car diopulmonary resuscitation during transport were included. Patients younger than 16 years and those with missing data were excluded. We compared two groups using propensity score matching. The primary outcome was survival to discharge. The secondary outcome was return of spontaneous circulation (ROSC) on hospital arrival. A logistic regression model was used to calculate odds ratios (OR) and confidence intervals (CI). Results: After propensity score matching, 1,346 patients were enrolled (AAM 673 versus non-AAM 673). Forty-four AAM cases (6.5%) and 39 non-AAM cases (5.8%) survived. Logistic regression analysis did not show a contribution of AAM for survival to discharge (AAM 44/673 (6.5%), non-AAM 39/673 (5.8%); OR 1.12; 95% CI, 0.70-1.76; P = 0.64). However, AAM improved ROSC on admission (AAM 141/673 (21.0%), non-AAM 77/673 (11.4%); OR 2.05; 95% CI, 1.51-2.78; P < 0.001). This tendency was consistent throughout our subgroup analysis categorized by body region of the severe injury (head trauma, torso trauma, and extremity/spine trauma). Conclusions: Prehospital AAM among EMS-witnessed traumatic OHCA patients was not associated with survival to discharge; however, ROSC on hospital admission improved for the AAM patients.
en-copyright=
kn-copyright=

en-aut-name=NishimuraTakeshi
en-aut-sei=Nishimura
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugaMasafumi
en-aut-sei=Suga
en-aut-mei=Masafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiharaSatoshi
en-aut-sei=Ishihara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center
kn-affil=

affil-num=5
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=AAM
kn-keyword=AAM
en-keyword=Endotracheal intubation
kn-keyword=Endotracheal intubation
en-keyword=JTDB
kn-keyword=JTDB
en-keyword=supraglottic airway
kn-keyword=supraglottic airway
en-keyword=traumatic cardiac arrest
kn-keyword=traumatic cardiac arrest
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=6
article-no=
start-page=227
end-page=282
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220610
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=On the origin and evolution of the asteroid Ryugu: A comprehensive geochemical perspective
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Presented here are the observations and interpretations from a comprehensive analysis of 16 representative particles returned from the C-type asteroid Ryugu by the Hayabusa2 mission. On average Ryugu particles consist of 50% phyllosilicate matrix, 41% porosity and 9% minor phases, including organic matter. The abundances of 70 elements from the particles are in close agreement with those of CI chondrites. Bulk Ryugu particles show higher δ18O, Δ17O, and ε54Cr values than CI chondrites. As such, Ryugu sampled the most primitive and least-thermally processed protosolar nebula reservoirs. Such a finding is consistent with multi-scale H-C-N isotopic compositions that are compatible with an origin for Ryugu organic matter within both the protosolar nebula and the interstellar medium. The analytical data obtained here, suggests that complex soluble organic matter formed during aqueous alteration on the Ryugu progenitor planetesimal (several 10’s of km), <2.6 Myr after CAI formation. Subsequently, the Ryugu progenitor planetesimal was fragmented and evolved into the current asteroid Ryugu through sublimation.
en-copyright=
kn-copyright=

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en-aut-name=SOEJIMAHiromichi
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en-aut-name=SUZUKIAyako
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en-aut-name=USUITomohiro
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ORCID=

en-aut-name=YADAToru
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ORCID=

en-aut-name=YAMAMOTODaiki
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en-aut-name=YOGATAKasumi
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ORCID=

en-aut-name=YOSHITAKEMiwa
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ORCID=

en-aut-name=ARAKAWAMasahiko
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en-aut-name=FUJIIAtsushi
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en-aut-name=HAYAKAWAMasahiko
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en-aut-name=HIRATANaoyuki
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ORCID=

en-aut-name=HIRATANaru
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ORCID=

en-aut-name=HONDARie
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en-aut-name=IIJIMAYu-ichi
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ORCID=

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en-aut-name=ISHIGUROMasateru
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en-aut-name=KIKUCHIShota
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en-aut-name=KITAZATOKohei
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en-aut-name=MATSUMOTOKoji
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ORCID=

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ORCID=

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ORCID=

en-aut-name=OKAMOTOChisato
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ORCID=

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ORCID=

en-aut-name=OZAKIMasanobu
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ORCID=

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ORCID=

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ORCID=

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ORCID=

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ORCID=

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ORCID=

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ORCID=

en-aut-name=TAKEIYuto
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aut-affil-num=73
ORCID=

en-aut-name=TAKEUCHIHiroshi
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aut-affil-num=74
ORCID=

en-aut-name=TANAKASatoshi
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ORCID=

en-aut-name=TATSUMIEri
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en-aut-mei=Eri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=76
ORCID=

en-aut-name=TERUIFuyuto
en-aut-sei=TERUI
en-aut-mei=Fuyuto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=77
ORCID=

en-aut-name=TSUKIZAKIRyudo
en-aut-sei=TSUKIZAKI
en-aut-mei=Ryudo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=78
ORCID=

en-aut-name=WADAKoji
en-aut-sei=WADA
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=79
ORCID=

en-aut-name=YAMADAManabu
en-aut-sei=YAMADA
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=80
ORCID=

en-aut-name=YAMADATetsuya
en-aut-sei=YAMADA
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=81
ORCID=

en-aut-name=YAMAMOTOYukio
en-aut-sei=YAMAMOTO
en-aut-mei=Yukio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=82
ORCID=

en-aut-name=YANOHajime
en-aut-sei=YANO
en-aut-mei=Hajime
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=83
ORCID=

en-aut-name=YOKOTAYasuhiro
en-aut-sei=YOKOTA
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=84
ORCID=

en-aut-name=YOSHIHARAKeisuke
en-aut-sei=YOSHIHARA
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=85
ORCID=

en-aut-name=YOSHIKAWAMakoto
en-aut-sei=YOSHIKAWA
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=86
ORCID=

en-aut-name=YOSHIKAWAKent
en-aut-sei=YOSHIKAWA
en-aut-mei=Kent
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=87
ORCID=

en-aut-name=FUJIMOTOMasaki
en-aut-sei=FUJIMOTO
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=88
ORCID=

en-aut-name=WATANABESei-ichiro
en-aut-sei=WATANABE
en-aut-mei=Sei-ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=89
ORCID=

en-aut-name=TSUDAYuichi
en-aut-sei=TSUDA
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=90
ORCID=

affil-num=1
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=3
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=4
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=5
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=6
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=7
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=8
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=9
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=10
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=11
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=12
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=13
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=14
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=15
en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Information and Basic Science, Nagoya City University
kn-affil=

affil-num=17
en-affil=The Graduate University for Advanced Studies (SOKENDAI)
kn-affil=

affil-num=18
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=19
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=20
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=21
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=22
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=23
en-affil=Marine Works Japan, Ltd.
kn-affil=

affil-num=24
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=25
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=26
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=27
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=28
en-affil=Marine Works Japan, Ltd.
kn-affil=

affil-num=29
en-affil=Graduate School of Science, The University of Tokyo
kn-affil=

affil-num=30
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=31
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=32
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=33
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=34
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=35
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=36
en-affil=Graduate School of Science, Kobe University
kn-affil=

affil-num=37
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=38
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=39
en-affil=Graduate School of Science, Kobe University
kn-affil=

affil-num=40
en-affil=Faculty of Computer Science and Engineering, The University of Aizu
kn-affil=

affil-num=41
en-affil=Faculty of Science and Technology, Kochi University
kn-affil=

affil-num=42
en-affil=Faculty of Computer Science and Engineering, The University of Aizu
kn-affil=

affil-num=43
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=44
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=45
en-affil=Research and Development Directorate, JAXA
kn-affil=

affil-num=46
en-affil=Department of Physics and Astronomy, Seoul National University
kn-affil=

affil-num=47
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=48
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=49
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=50
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=51
en-affil=Faculty of Computer Science and Engineering, The University of Aizu
kn-affil=

affil-num=52
en-affil=National Astronomical Observatory of Japan
kn-affil=

affil-num=53
en-affil=Observatoire de Paris
kn-affil=

affil-num=54
en-affil=Faculty of Engineering, Kindai University
kn-affil=

affil-num=55
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=56
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=57
en-affil=Graduate School of Environmental Studies, Nagoya University
kn-affil=

affil-num=58
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=59
en-affil=National Astronomical Observatory of Japan
kn-affil=

affil-num=60
en-affil=National Astronomical Observatory of Japan
kn-affil=

affil-num=61
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=62
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=63
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=64
en-affil=Graduate School of Science, Kobe University
kn-affil=

affil-num=65
en-affil=Research and Development Directorate, JAXA
kn-affil=

affil-num=66
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=67
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=68
en-affil=College of Science, Rikkyo University
kn-affil=

affil-num=69
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=70
en-affil=Planetary Exploration Research Center (PERC), Chiba Institute of Technology
kn-affil=

affil-num=71
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=72
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=73
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=74
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=75
en-affil=The Graduate University for Advanced Studies (SOKENDAI)
kn-affil=

affil-num=76
en-affil=Graduate School of Science, The University of Tokyo
kn-affil=

affil-num=77
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=78
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=79
en-affil=Planetary Exploration Research Center (PERC), Chiba Institute of Technology
kn-affil=

affil-num=80
en-affil=Planetary Exploration Research Center (PERC), Chiba Institute of Technology
kn-affil=

affil-num=81
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=82
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=83
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=84
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=85
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=86
en-affil=The Graduate University for Advanced Studies (SOKENDAI)
kn-affil=

affil-num=87
en-affil=Research and Development Directorate, JAXA
kn-affil=

affil-num=88
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=

affil-num=89
en-affil=Graduate School of Environmental Studies, Nagoya University
kn-affil=

affil-num=90
en-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=56
cd-vols=
no-issue=
article-no=
start-page=218
end-page=222
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Prehospital emergency life-saving technicians promote the survival of trauma patients: A retrospective cohort study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective<br>
Appropriate decisions by medical technicians at a trauma scene may influence a patient's prognosis. Emergency life-saving technicians (ELSTs) are certified specialists trained with the knowledge to provide advanced techniques for prehospital emergency care in Japan. However, the benefit of treatment by ELSTs compared to basic emergency medical technicians (BEMTs) remains unclear. The aim of this study is to determine whether treatment by ELSTs improves outcomes for trauma patients.<br>
<br>
Methods<br>
We retrospectively reviewed the Japan Trauma Data Bank for the years 2004 to 2017. Patients transferred to the hospital directly from the trauma scene and at least 16 years old were included in this study. The following criteria were used to exclude patients; presence of burns, untreatable severe traumas, unknown ELST attendance, and missing prognosis. We compared two groups (ELST group: patients transported by emergency medical services (EMS) with the presence of at least one ELST; BEMT group: patients transported only by BEMTs). Primary outcome was survival to discharge. Secondary outcomes were the need of definitive treatments defined by surgical intervention, intravascular radiology and blood transfusion at the receiving hospital within 24 h. A multivariable logistic regression model was used to calculate odds ratio (OR) and confidence intervals (CI) adjusted by age, sex, revised trauma score, and Injury severity score (ISS).<br>
<br>
Results<br>
Overall survival to discharge did not improve significantly (adjusted OR 1.13, 95% CI 0.99?1.30) with ELST intervention. In-hospital blood transfusion was more frequently required in the ELST group (adjusted OR 1.10, 95% CI 1.01?1.20). Emergency interventions (adjusted OR 1.03, 95% CI 0.97?1.09) were not different between the groups. In stratified analysis, the benefit of ELST attendance for survival was observed among patients with ISS <16 (adjusted OR 1.53, 95% CI 1.10?2.15), aged 65 years or older (adjusted OR 1.27, 95% CI 1.07?1.52), during the earlier study period (2004?2008, adjusted OR 1.50, 95% CI 1.14?1.97), and shorter transportation time (adjusted OR 1.21, 95% CI 1.03?1.41).<br>
<br>
Conclusions<br>
Dispatch systems with ELST should be considered for trauma transports, which may benefit elderly or moderate severity trauma groups, with shorter transportation time conditions.
en-copyright=
kn-copyright=

en-aut-name=NishimuraTakeshi
en-aut-sei=Nishimura
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NojimaTsuyoshi
en-aut-sei=Nojima
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiharaSatoshi
en-aut-sei=Ishihara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakayamaShinichi
en-aut-sei=Nakayama
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center
kn-affil=

affil-num=5
en-affil=Department of Emergency and Critical Care Medicine, Hyogo Emergency Medical Center
kn-affil=

affil-num=6
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=JTDB
kn-keyword=JTDB
en-keyword=Prehospital
kn-keyword=Prehospital
en-keyword=Emergency life-saving technician
kn-keyword=Emergency life-saving technician
en-keyword=Trauma
kn-keyword=Trauma
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=3
article-no=
start-page=247
end-page=253
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis of Immunity against Measles, Mumps, Rubella, and Varicella Zoster in Adult Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: A Single-Center Experience
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Vaccine-preventable disease (VPD) infections are more severe in immunocompromised hosts. Vaccination against measles, mumps, rubella, and varicella zoster (VZV) (MMRV) is therefore recommended for hematopoietic stem cell transplantation (HCT) recipients. However, studies on adult HCT recipients with VPD infections are limited. At our institution, we have systematically conducted serological MMRV tests as a part of check-up examinations during long-term follow-up (LTFU) after HCT since 2015. This retrospective study aimed to evaluate changes in the serostatus between before and 2 years after allogeneic HCT. Among 161 patients, the pre-transplant seropositivity was 82.7% for measles, 86.8% for mumps, 84.2% for rubella, and 94.3% for VZV. Among 56 patients who underwent LTFU including serological MMRV tests at 2 years after HCT, the percentages maintaining seroprotective antibody levels for measles, mumps, rubella and VZV were 71.5% (40/56), 51.8% (29/56), 48.2% (27/56), and 60.7% (34/56), respectively. Vaccination was recommended for 22 patients, and 12 were vaccinated. Among the 12 vaccinated patients, rates of seroconversion were examined in 2-6 patients for each of the four viruses. They were 100% (3/3) for measles, 33.3% (1/3) for mumps, 50% (3/6) for rubella, and 0% (0/2) for VZV. Further studies are warranted to clarify the effect of vaccination in adult HCT recipients.
en-copyright=
kn-copyright=

en-aut-name=YoshidaShohei
en-aut-sei=Yoshida
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujiiNobuharu
en-aut-sei=Fujii
en-aut-mei=Nobuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KamoiChihiro
en-aut-sei=Kamoi
en-aut-mei=Chihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KitamuraWataru
en-aut-sei=Kitamura
en-aut-mei=Wataru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiwaraHideaki
en-aut-sei=Fujiwara
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AsadaNoboru
en-aut-sei=Asada
en-aut-mei=Noboru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NishimoriHisakazu
en-aut-sei=Nishimori
en-aut-mei=Hisakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=FujiiKeiko
en-aut-sei=Fujii
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsuokaKen-ichi
en-aut-sei=Matsuoka
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=vaccine-preventable disease
kn-keyword=vaccine-preventable disease
en-keyword=vaccination
kn-keyword=vaccination
en-keyword=allogeneic hematopoietic stem cell transplantation
kn-keyword=allogeneic hematopoietic stem cell transplantation
en-keyword=adult
kn-keyword=adult
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ヤマトシリアゲPanorpa japonicaにおける雄の交尾戦術とそれに関する行動と形態について
kn-title=Mating tactics and related behaviors and morphology of males in the Japanese scorpionfly Panorpa japonica
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaRyo
en-aut-sei=Ishihara
en-aut-mei=Ryo
kn-aut-name=石原凌
kn-aut-sei=石原
kn-aut-mei=凌
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=2
article-no=
start-page=e8533
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220207
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Freezing or death feigning? Beetles selected for long death feigning showed different tactics against different predators
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Prey evolve antipredator strategies against multiple enemies in nature. We examined how a prey species adopts different predation avoidance tactics against pursuit or sit-and-wait predators. As prey, we used three strains of Tribolium beetles artificially selected for short (short strain) or long (long strain) duration of death feigning, and a stock culture (base population). Death feigning is known to be effective for evading a jumping spider in the case of the long strains, while the present study showed that the long-strain beetles used freezing against a sit-and-wait type predator, Amphibolus venator, in this study. The short- strain beetles were more easily oriented toward predators. The time to predation was also shorter in the short strains compared to the long strains. The results showed that, as prey, the short strains displayed the same behavior, escaping, against both types of predators. Traditionally, death feigning has been thought to be the last resort in a series of antipredator avoidance behaviors. However, our results showed that freezing and death feigning were not parts of a series of behaviors, but independent strategies against different predators, at least for long-strain beetles. We also examined the relationship between a predator's starvation level and its predatory behavior. In addition, the orientation behavior toward and predation rate on the prey were observed to determine how often the predatory insect attacked the beetles.
en-copyright=
kn-copyright=

en-aut-name=AsakuraMasaya
en-aut-sei=Asakura
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshiharaRyo
en-aut-sei=Ishihara
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Agriculture, Kagawa University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=animal hypnosis
kn-keyword=animal hypnosis
en-keyword=death feigning
kn-keyword=death feigning
en-keyword=freezing
kn-keyword=freezing
en-keyword=predation
kn-keyword=predation
en-keyword=thanatosis
kn-keyword=thanatosis
en-keyword=tonic immobility
kn-keyword=tonic immobility
END

start-ver=1.4
cd-journal=joma
no-vol=67
cd-vols=
no-issue=2
article-no=
start-page=112
end-page=117
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210320
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Lemierre's syndrome following peritonsillar abscess : A case report
kn-title=扁桃周囲膿瘍からレミエール症候群を来した 1 例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Lemierre's syndrome is a disorder in which bacterial infection of the head and neck region leads to thrombosis of the internal jugular vein ; left untreated, this condition can also result in metastatic infections in the lungs and joints as well as bacterial sepsis. An early diagnosis and treatment are important for preventing these pathologic outcomes. We herein report the case of a 30-year-old male with internal jugular vein thrombosis secondary to a peritonsillar abscess accompanied by septic emboli in the lung. The criteria proposed by Yamamoto and Sugiura et al. were used to facilitate a rapid diagnosis of his condition prior to obtaining results from blood cultures. While Lemierre's syndrome is a fairly uncommon diagnosis at this time, its incidence has been increasing given the current pressure to limit the use of antibiotics. Antimicrobial use is currently restricted in Japan due to efforts designed to curb the emergence of drug resistance; as such, we may begin to see more cases of this disease. Although rare, some patients with infection of the head and neck region do develop Lemierre's syndrome ; as such, frequent follow-up of all cases of acute pharyngitis is necessary, notably for those patients not treated with antimicrobial agents.
en-copyright=
kn-copyright=

en-aut-name=KAJIHARASohei
en-aut-sei=KAJIHARA
en-aut-mei=Sohei
kn-aut-name=梶原壮平
kn-aut-sei=梶原
kn-aut-mei=壮平
aut-affil-num=1
ORCID=

en-aut-name=ISHIHARAHisashi
en-aut-sei=ISHIHARA
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=2
ORCID=

en-aut-name=KARIYAAkifumi
en-aut-sei=KARIYA
en-aut-mei=Akifumi
kn-aut-name=假谷彰文
kn-aut-sei=假谷
kn-aut-mei=彰文
aut-affil-num=3
ORCID=

en-aut-name=AKISADANaoki
en-aut-sei=AKISADA
en-aut-mei=Naoki
kn-aut-name=秋定直樹
kn-aut-sei=秋定
kn-aut-mei=直樹
aut-affil-num=4
ORCID=

en-aut-name=SHIGEHARAAkiko
en-aut-sei=SHIGEHARA
en-aut-mei=Akiko
kn-aut-name=茂原暁子
kn-aut-sei=茂原
kn-aut-mei=暁子
aut-affil-num=5
ORCID=

en-aut-name=SATOAki
en-aut-sei=SATO
en-aut-mei=Aki
kn-aut-name=佐藤晶
kn-aut-sei=佐藤
kn-aut-mei=晶
aut-affil-num=6
ORCID=

en-aut-name=HAMADAKoji
en-aut-sei=HAMADA
en-aut-mei=Koji
kn-aut-name=�M田浩司
kn-aut-sei=�M田
kn-aut-mei=浩司
aut-affil-num=7
ORCID=

en-aut-name=AKAGIYusuke
en-aut-sei=AKAGI
en-aut-mei=Yusuke
kn-aut-name=赤木祐介
kn-aut-sei=赤木
kn-aut-mei=祐介
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Otorhinolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター耳鼻咽喉科

affil-num=2
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=3
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=4
en-affil=Department of Head and Neck Surgery, Shikoku Cancer Center
kn-affil=国立病院機構四国がんセンター頭頸科

affil-num=5
en-affil=Department of Otorhinolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター耳鼻咽喉科

affil-num=6
en-affil=Department of Otorhinolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター耳鼻咽喉科

affil-num=7
en-affil=Department of Otorhinolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター耳鼻咽喉科

affil-num=8
en-affil=Department of Otorhinolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター耳鼻咽喉科
en-keyword= Lemierre's syndrome
kn-keyword= Lemierre's syndrome
en-keyword=Fusobacterium necrophorum
kn-keyword=Fusobacterium necrophorum
en-keyword=Antimicrobial Resistance
kn-keyword=Antimicrobial Resistance
en-keyword=扁桃周囲膿瘍
kn-keyword=扁桃周囲膿瘍
en-keyword=耳鼻咽喉科救急
kn-keyword=耳鼻咽喉科救急
END

start-ver=1.4
cd-journal=joma
no-vol=133
cd-vols=
no-issue=3
article-no=
start-page=147
end-page=150
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2020 Incentive Award of the Okayama Medical Association in Neuroscience (2020 Niimi Prize)
kn-title=令和２年度岡山医学会賞紹介記事脳神経研究奨励賞（新見賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MikiTomoko
en-aut-sei=Miki
en-aut-mei=Tomoko
kn-aut-name=三木知子
kn-aut-sei=三木
kn-aut-mei=知子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学
END

start-ver=1.4
cd-journal=joma
no-vol=32
cd-vols=
no-issue=1
article-no=
start-page=66
end-page=69
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=
dt-pub=
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case with difficulty in airway management nevertheless switching from emergency tracheostomy to cricothyrotomy
kn-title=緊急気管切開中に輪状甲状膜切開に切り替えるも気道確保に難渋した1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=深頸部膿瘍は時に急速な喉頭浮腫を来たし窒息に至ることもある救急疾患である．深夜に救急外来を受診し手術室にて気道確保中に窒息をきたし，院内コードブルー発動を経て救命し得た深頸部膿瘍の1例を経験したので報告する．症例は60代男性．増悪する咽頭痛，軽度の呼吸苦を主訴に当院へ救急搬送された来院後より次第に呼吸苦が増悪し，甲状軟骨内側の膿瘍および高度の喉頭浮腫を認め，気管切開による気道確保を計画した．術中，窒息が切迫した状態となり迅速に気道を確保するために輪状甲状膜切開に術式を切り替えた．しかし，呼吸苦から体動が多く不穏となりまた体動・出血に伴い窒息に至り，徐々に血中酸素飽和度が低下していった通常の手術続行が不可能となった段階で院内コードブルーを要請し，人員を集め，輪状甲状間膜切開・気道確保に成功した最終的には後遺症なく救命が可能であった．
en-copyright=
kn-copyright=

en-aut-name=Akifumi Kariya
en-aut-sei=Akifumi 
en-aut-mei=Kariya
kn-aut-name=假谷彰文
kn-aut-sei=假谷
kn-aut-mei=彰文
aut-affil-num=1
ORCID=

en-aut-name=IshiharaHisashi
en-aut-sei=Ishihara
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=2
ORCID=

en-aut-name=AkisadaNaoki
en-aut-sei=Akisada
en-aut-mei=Naoki
kn-aut-name=秋定直樹
kn-aut-sei=秋定
kn-aut-mei=直樹
aut-affil-num=3
ORCID=

en-aut-name=HamadaKoji
en-aut-sei=Hamada
en-aut-mei=Koji
kn-aut-name=濱田浩司
kn-aut-sei=濱田
kn-aut-mei=浩司
aut-affil-num=4
ORCID=

en-aut-name=FujiSyaka
en-aut-sei=Fuji
en-aut-mei=Syaka
kn-aut-name=藤さやか
kn-aut-sei=藤
kn-aut-mei=さやか
aut-affil-num=5
ORCID=

en-aut-name=AkagiSeiko
en-aut-sei=Akagi
en-aut-mei=Seiko
kn-aut-name=赤木成子
kn-aut-sei=赤木
kn-aut-mei=成子
aut-affil-num=6
ORCID=

en-aut-name=AkazawaAnna
en-aut-sei=Akazawa
en-aut-mei=Anna
kn-aut-name=赤澤杏奈
kn-aut-sei=赤澤
kn-aut-mei=杏奈
aut-affil-num=7
ORCID=

en-aut-name=TakeuchiAyako
en-aut-sei=Takeuchi
en-aut-mei=Ayako
kn-aut-name=竹内彩子
kn-aut-sei=竹内
kn-aut-mei=彩子
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama
kn-affil=岡山赤十字病院 耳鼻咽喉科

affil-num=2
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama
kn-affil=岡山赤十字病院 耳鼻咽喉科

affil-num=3
en-affil=Department of Otolaryngology Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceu tical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科耳鼻咽喉・頭頸部外科学

affil-num=4
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama
kn-affil=岡山赤十字病院 耳鼻咽喉科

affil-num=5
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama
kn-affil=岡山赤十字病院 耳鼻咽喉科

affil-num=6
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama
kn-affil=岡山赤十字病院 耳鼻咽喉科

affil-num=7
en-affil=Department of Anesthesiology , Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院 麻酔科

affil-num=8
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama
kn-affil=岡山赤十字病院 耳鼻咽喉科
en-keyword=tracheostomy
kn-keyword=tracheostomy
en-keyword=cricothyrotomy
kn-keyword=cricothyrotomy
en-keyword=laryngeal edema
kn-keyword=laryngeal edema
en-keyword=ENT emergency
kn-keyword=ENT emergency
en-keyword=deep neck abscess
kn-keyword=deep neck abscess
END

start-ver=1.4
cd-journal=joma
no-vol=67
cd-vols=
no-issue=1
article-no=
start-page=26
end-page=30
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210120
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=HIV infection diagnosed from delayed wound healing after tonsillectomy : A case report
kn-title=口蓋扁桃摘出術後の創傷治癒遅延を契機に判明した HIV 感染症の1例
en-subtitle=
kn-subtitle=
en-abstract=HIV (human immunodeficiency virus) lowers the immune capacity of the host and causes AIDS (acquired immunodeficiency syndrome) when it progresses. HIV infection is known to have a variety of symptoms, and it is often diagnosed based on the occurrence of various otorhinolaryngological conditions. We experienced a case in which an HIV infection was diagnosed based on delayed wound healing after tonsillectomy. The early initiation of treatment for HIV infection is known to be effective for controlling progression, so it is important to detect HIV infection as early as possible. Preoperative HIV screening tests may lead to the early detection of HIV, and such tests are also important to prevent delayed wound healing. In Japan, it remains a problem that preoperative HIV screening is sometimes not allowed under by the Japanese National health insurance system.
kn-abstract=HIV（human immunodeficiency virus）は感染すると宿主の免疫能を低下させ、進行すると AIDS（acquired immunodeficiency syndrome）を引き起こす。HIV 感染症は多彩な症状を呈することが知られており、創傷治癒遅延もその一つである。今回われわれは口蓋扁桃摘出術後の創傷治癒遅延から HIV 感染症と判明した症例を経験した。HIV 感染症は早期の治療開始が予後改善のために推奨されており、早期発見が重要である。手術前 HIV スクリーニング検査は創傷治癒遅延を防ぐ意味でも重要と考えられるが、現行の保険制度上は認められない場合があり、保険適用範囲の拡大が望まれる。
en-copyright=
kn-copyright=

en-aut-name=KariyaAkifumi
en-aut-sei=Kariya
en-aut-mei=Akifumi
kn-aut-name=假谷彰文
kn-aut-sei=假谷
kn-aut-mei=彰文
aut-affil-num=1
ORCID=

en-aut-name=IshiharaHisashi
en-aut-sei=Ishihara
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=2
ORCID=

en-aut-name=AkisadaNaoki
en-aut-sei=Akisada
en-aut-mei=Naoki
kn-aut-name=秋定直樹
kn-aut-sei=秋定
kn-aut-mei=直樹
aut-affil-num=3
ORCID=

en-aut-name=FujisawaIku
en-aut-sei=Fujisawa
en-aut-mei=Iku
kn-aut-name=藤澤郁
kn-aut-sei=藤澤
kn-aut-mei=郁
aut-affil-num=4
ORCID=

en-aut-name=FujiSayaka
en-aut-sei=Fuji
en-aut-mei=Sayaka
kn-aut-name=藤さやか
kn-aut-sei=藤
kn-aut-mei=さやか
aut-affil-num=5
ORCID=

en-aut-name=AkagiSeiko
en-aut-sei=Akagi
en-aut-mei=Seiko
kn-aut-name=赤木成子
kn-aut-sei=赤木
kn-aut-mei=成子
aut-affil-num=6
ORCID=

en-aut-name=TakeuchiAyako
en-aut-sei=Takeuchi
en-aut-mei=Ayako
kn-aut-name=竹内彩子
kn-aut-sei=竹内
kn-aut-mei=彩子
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=2
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=3
en-affil=Department of Head and Neck Surgery, Shikoku Cancer Center
kn-affil=国立病院機構四国がんセンター頭頸科

affil-num=4
en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科耳鼻咽喉・頭頸部外科学

affil-num=5
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=6
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=7
en-affil=Department of Otorhinolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院耳鼻咽喉科
en-keyword=HIV（human immunodeficiency virus）
kn-keyword=HIV（human immunodeficiency virus）
en-keyword=創傷治癒遅延
kn-keyword=創傷治癒遅延
en-keyword=口蓋扁桃摘出術
kn-keyword=口蓋扁桃摘出術
en-keyword=手術合併症
kn-keyword=手術合併症
en-keyword=性感染症
kn-keyword=性感染症
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=6
article-no=
start-page=763
end-page=766
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Clinical Efficacy and Safety of Sitafloxacin 200 mg Once Daily for Refractory Genitourinary Tract Infections
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this ongoing trial is to evaluate the clinical efficacy and safety of sitafloxacin (STFX) 200 mg once daily (QD) for 7 days in patients with refractory genitourinary tract infections, which include recurrent or complicated cystitis, complicated pyelonephritis, bacterial prostatitis, and epididymitis. The primary endpoint is the microbiological efficacy at 5-9 days after the last administration of STFX. Recruitment began in February 2021, and the target total sample size is 92 participants.
en-copyright=
kn-copyright=

en-aut-name=IwataTakehiro
en-aut-sei=Iwata
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SadahiraTakuya
en-aut-sei=Sadahira
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MaruyamaYuki
en-aut-sei=Maruyama
en-aut-mei=Yuki
kn-aut-name=
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en-aut-name=SekitoTakanori
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en-aut-name=YoshinagaKasumi
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en-aut-name=WatariShogo
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en-aut-name=NagaoKentaro
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en-aut-name=KawadaTatsushi
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en-aut-name=TominagaYusuke
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en-aut-name=NishimuraShingo
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en-aut-name=TakamotoAtsushi
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en-aut-name=SakoTomoko
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en-aut-name=EdamuraKohei
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en-aut-name=KobayashiYasuyuki
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en-aut-name=ArakiMotoo
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en-aut-name=IshiiAyano
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ORCID=

en-aut-name=WatanabeMasami
en-aut-sei=Watanabe
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kn-aut-sei=
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ORCID=

en-aut-name=WatanabeToyohiko
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kn-aut-sei=
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en-aut-name=NasuYasutomo
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kn-aut-sei=
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en-aut-name=WadaKoichiro
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

affil-num=1
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=14
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=15
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=16
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=17
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=18
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=19
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=20
en-affil=Department of Urology, Okayama University Hospital
kn-affil=
en-keyword=genitourinary tract infections
kn-keyword=genitourinary tract infections
en-keyword=fluoroquinolone resistance
kn-keyword=fluoroquinolone resistance
en-keyword=extended-spectrum beta-lactamase
kn-keyword=extended-spectrum beta-lactamase
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=6
article-no=
start-page=735
end-page=739
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Multiple Hepatolithiasis Following Hepaticojejunostomy Successfully Treated with Left Hemihepatectomy and Double Hepaticojejunostomy Reconstruction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Surgical intervention for hepatolithiasis following hepaticojejunostomy (HJ) has rarely been reported. Herein, we present a case of post-HJ multiple hepatolithiasis treated with left hemihepatectomy with double HJ reconstruction. A 72-year-old woman who had undergone HJ for iatrogenic bile duct injury developed repeated cholangitis due to complicated hepatolithiasis accompanied by an atrophied left hepatic lobe and HJ stricture. Since endoscopic intervention was unsuccessful, the patient underwent left hemihepatectomy with HJ re-anastomoses of the common hepatic duct and left hepatic duct (double HJ technique). The double HJ technique with hepatectomy can be a useful option for treating complicated hepatolithiasis following HJ.
en-copyright=
kn-copyright=

en-aut-name=NagaiYasuo
en-aut-sei=Nagai
en-aut-mei=Yasuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakagiKosei
en-aut-sei=Takagi
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KuiseTakashi
en-aut-sei=Kuise
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YoshidaRyuichi
en-aut-sei=Yoshida
en-aut-mei=Ryuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YoshidaKazuhiro
en-aut-sei=Yoshida
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YasuiKazuya
en-aut-sei=Yasui
en-aut-mei=Kazuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=FujiwaraToshiyoshi
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=hepatolithiasis
kn-keyword=hepatolithiasis
en-keyword=hepaticojejunostomy
kn-keyword=hepaticojejunostomy
en-keyword=hepatectomy
kn-keyword=hepatectomy
END

start-ver=1.4
cd-journal=joma
no-vol=29
cd-vols=
no-issue=3-4
article-no=
start-page=361
end-page=371
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211014
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effectiveness of Create ML in microscopy image classifications: a simple and inexpensive deep learning pipeline for non-data scientists
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Observing chromosomes is a time-consuming and labor-intensive process, and chromosomes have been analyzed manually for many years. In the last decade, automated acquisition systems for microscopic images have advanced dramatically due to advances in their controlling computer systems, and nowadays, it is possible to automatically acquire sets of tiling-images consisting of large number, more than 1000, of images from large areas of specimens. However, there has been no simple and inexpensive system to efficiently select images containing mitotic cells among these images. In this paper, a classification system of chromosomal images by deep learning artificial intelligence (AI) that can be easily handled by non-data scientists was applied. With this system, models suitable for our own samples could be easily built on a Macintosh computer with Create ML. As examples, models constructed by learning using chromosome images derived from various plant species were able to classify images containing mitotic cells among samples from plant species not used for learning in addition to samples from the species used. The system also worked for cells in tissue sections and tetrads. Since this system is inexpensive and can be easily trained via deep learning using scientists’ own samples, it can be used not only for chromosomal image analysis but also for analysis of other biology-related images.
en-copyright=
kn-copyright=

en-aut-name=NagakiKiyotaka
en-aut-sei=Nagaki
en-aut-mei=Kiyotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurutaTomoyuki
en-aut-sei=Furuta
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamajiNaoki
en-aut-sei=Yamaji
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KuniyoshiDaichi
en-aut-sei=Kuniyoshi
en-aut-mei=Daichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshiharaMegumi
en-aut-sei=Ishihara
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KishimaYuji
en-aut-sei=Kishima
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MurataMinoru
en-aut-sei=Murata
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HoshinoAtsushi
en-aut-sei=Hoshino
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TakatsukaHirotomo
en-aut-sei=Takatsuka
en-aut-mei=Hirotomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Laboratory of Plant Breeding, Research Faculty of Agriculture, Hokkaido University
kn-affil=

affil-num=5
en-affil=Laboratory of Plant Breeding, Research Faculty of Agriculture, Hokkaido University
kn-affil=

affil-num=6
en-affil=Laboratory of Plant Breeding, Research Faculty of Agriculture, Hokkaido University
kn-affil=

affil-num=7
en-affil=Department of Agricultural and Food Science, Universiti Tunku Abdul Rahman
kn-affil=

affil-num=8
en-affil=National Institute for Basic Biology
kn-affil=

affil-num=9
en-affil=Graduate School of Science and Technology, Nara Institute of Science and Technology
kn-affil=
en-keyword=Machine learning
kn-keyword=Machine learning
en-keyword=deep learning
kn-keyword=deep learning
en-keyword=mitotic cell
kn-keyword=mitotic cell
en-keyword=chromosome
kn-keyword=chromosome
en-keyword=tetrad
kn-keyword=tetrad
en-keyword=microscope
kn-keyword=microscope
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=5
article-no=
start-page=663
end-page=667
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Clinical Trial Evaluating the Usefulness of Tailored Antimicrobial Prophylaxis Using Rectal-culture Screening Media Prior to Transrectal Prostate Biopsy: A Multicenter, Randomized Controlled Trial
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this report is to introduce an on-going, multicenter, randomized controlled trial to evaluate whether tailored antimicrobial prophylaxis guided by rectal culture screening prevents acute bacterial prostatitis following transrectal prostate biopsy (TRPB). Patients will be randomized into an intervention or non-intervention group; tazobactam-piperacillin or levofloxacin will be prophylactically administered according to the results of rectal culture prior to TRPB in the intervention group whereas levofloxacin will be routinely given in the non-intervention group. The primary endpoint is the occurrence rate of acute bacterial prostatitis after TRPB. Recruitment begins in April, 2021 and the target total sample size is 5,100 participants.
en-copyright=
kn-copyright=

en-aut-name=SadahiraTakuya
en-aut-sei=Sadahira
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MaruyamaYuki
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kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HiyamaYoshiki
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aut-affil-num=3
ORCID=

en-aut-name=KitanoHiroyuki
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kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamadaHiroki
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=GotoTakayuki
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kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KondoTsubasa
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShigemuraKatsumi
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MitsuiYosuke
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IwataTakehiro
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=EdamuraKohei
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=ArakiMotoo
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=WatanabeMasami
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=TakenakaTadasu
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=TeishimaJun
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=MiyataYasuyoshi
en-aut-sei=Miyata
en-aut-mei=Yasuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=IshikawaKiyohito
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=TakaokaEi-Ichiro
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en-aut-mei=Ei-Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=MiyazakiJun
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en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=TakahashiSatoshi
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en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=MasumoriNaoya
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en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=KiyotaHiroshi
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=FujisawaMasato
en-aut-sei=Fujisawa
en-aut-mei=Masato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

en-aut-name=YamamotoShingo
en-aut-sei=Yamamoto
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=24
ORCID=

en-aut-name=SakumaTakafumi
en-aut-sei=Sakuma
en-aut-mei=Takafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=25
ORCID=

en-aut-name=KusumiNorihiro
en-aut-sei=Kusumi
en-aut-mei=Norihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=26
ORCID=

en-aut-name=IchikawaTakaharu
en-aut-sei=Ichikawa
en-aut-mei=Takaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=27
ORCID=

en-aut-name=WatanabeToyohiko
en-aut-sei=Watanabe
en-aut-mei=Toyohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=28
ORCID=

en-aut-name=NasuYoshitsugu
en-aut-sei=Nasu
en-aut-mei=Yoshitsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=29
ORCID=

en-aut-name=TsugawaMasaya
en-aut-sei=Tsugawa
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=30
ORCID=

en-aut-name=NasuYasutomo
en-aut-sei=Nasu
en-aut-mei=Yasutomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=31
ORCID=

en-aut-name=WadaKoichiro
en-aut-sei=Wada
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=32
ORCID=

affil-num=1
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Hakodate Goryoukaku Hospital
kn-affil=

affil-num=4
en-affil=Hiroshima University Hospital
kn-affil=

affil-num=5
en-affil=Jikei University Katsushika Medical Center
kn-affil=

affil-num=6
en-affil=Kyoto University Hospital
kn-affil=

affil-num=7
en-affil=Nagasaki University Hospital
kn-affil=

affil-num=8
en-affil=Kobe University Hospital
kn-affil=

affil-num=9
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=14
en-affil=Japanese Red Cross Okayama Hospital
kn-affil=

affil-num=15
en-affil=Hiroshima University Hospital
kn-affil=

affil-num=16
en-affil=Nagasaki University Hospital
kn-affil=

affil-num=17
en-affil=Fujita Health University Hospital
kn-affil=

affil-num=18
en-affil=Internationla University of Health and Welfare Hospital
kn-affil=

affil-num=19
en-affil=Internationla University of Health and Welfare Hospital
kn-affil=

affil-num=20
en-affil=Sapporo Medical University Hospital
kn-affil=

affil-num=21
en-affil=Sapporo Medical University Hospital
kn-affil=

affil-num=22
en-affil=Jikei University Katsushika Medical Center
kn-affil=

affil-num=23
en-affil=Kobe University Hospital
kn-affil=

affil-num=24
en-affil=Hyogo College of Medicine College Hospital
kn-affil=

affil-num=25
en-affil=Okayama Medical Center
kn-affil=

affil-num=26
en-affil=Okayama Medical Center
kn-affil=

affil-num=27
en-affil=Okayama Medical Center
kn-affil=

affil-num=28
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=29
en-affil=Okayama Rosai Hospital
kn-affil=

affil-num=30
en-affil=Okayama City General Medical Center
kn-affil=

affil-num=31
en-affil=Department of Urology, Okayama University Hospital
kn-affil=

affil-num=32
en-affil=Department of Urology, Okayama University Hospital
kn-affil=
en-keyword=antibiotic prophylaxis
kn-keyword=antibiotic prophylaxis
en-keyword=selective culture media
kn-keyword=selective culture media
en-keyword=prostate biopsy
kn-keyword=prostate biopsy
en-keyword=fluoroquinolone-resistant
kn-keyword=fluoroquinolone-resistant
en-keyword=extended- spectrum beta-lactamase
kn-keyword=extended- spectrum beta-lactamase
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=20489448
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202011
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Method of Generating a Blacklist for Mobile Devices by Searching Malicious Websites
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=As mobile devices have become more popular, malware and attacks directed at them have significantly increased. One of the methods to attack mobile devices is redirecting a user to unwanted websites by unwanted page transition. One of the countermeasures against such attacks is to generate a blacklist of URLs and hostnames, which can prevent access to malicious websites. To generate a blacklist, first, malicious websites are collected in the web space. Then, URLs and hostnames of the malicious websites are added to the blacklist. However, URLs of the malicious websites are typically changed frequently; thus, it is necessary to keep track of the malicious websites and update the blacklist in a timely manner. In this study, we proposed a method to generate blacklists for mobile devices by searching malicious websites. The method collects many HTML files from the web space using a crawler and searches for HTML files that are highly likely to be malicious using keywords extracted from the known malicious websites to discover the new ones. Thus, new malicious websites can be added to the blacklist in a timely manner. Using the proposed method, we discovered malicious websites that were not detected by Google Safe Browsing. Moreover, the blacklist generated using the method had a high detection rate for certain malicious websites. This paper reports the design process and the results of the evaluation of the new method.
en-copyright=
kn-copyright=

en-aut-name=IshiharaTakashi
en-aut-sei=Ishihara
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SatoMasaya
en-aut-sei=Sato
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamauchiToshihiro
en-aut-sei=Yamauchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=Malicious Websites
kn-keyword=Malicious Websites
en-keyword=Blacklist
kn-keyword=Blacklist
en-keyword=Web-based Attack
kn-keyword=Web-based Attack
en-keyword=Android
kn-keyword=Android
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=1
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=2018129
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Web access monitoring mechanism for Android webview
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In addition to conventional web browsers, WebView is used to display web content on Android. WebView is a component that enables the display of web content in mobile applications, and is extensively used. As WebView displays web content without having to redirect the user to web browsers, there is the possibility that unauthorized web access may be performed secretly via Web-View, and information in Android may be stolen or tampered with. Therefore, it is necessary to monitor and analyze web access via WebView, particularly because attacks exploiting WebView have been reported. However, there is no mechanism for monitoring web access viaWebView. In this work, the goals are to monitor web access via WebView and to analyze mobile applications using Web-View. To achieve these goals, we propose a web access monitoring mechanism for Android WebView. In this paper, the design and implementation of a mechanism that does not require any modifications to the Android Framework and Linux kernel are presented for the Chromium Android System WebView app. In addition, this paper presents evaluation results for the proposed mechanism.
en-copyright=
kn-copyright=

en-aut-name=ImamuraYuta
en-aut-sei=Imamura
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UekawaHiroyuki
en-aut-sei=Uekawa
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshiharaYasuhiro
en-aut-sei=Ishihara
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SatoMasaya
en-aut-sei=Sato
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamauchiToshihiro
en-aut-sei=Yamauchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Okayama University, Okayama, Japan
kn-affil=

affil-num=2
en-affil=Okayama University, Okayama, Japan
kn-affil=

affil-num=3
en-affil=Okayama University, Okayama, Japan
kn-affil=

affil-num=4
en-affil=Okayama University, Okayama, Japan
kn-affil=

affil-num=5
en-affil=Okayama University Okayama, Japan
kn-affil=
en-keyword=Android
kn-keyword=Android
en-keyword= WebView
kn-keyword= WebView
en-keyword=Web access monitoring
kn-keyword=Web access monitoring
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=3
article-no=
start-page=279
end-page=287
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Gram-negative Rod Blood Stream Infection on Acute GVHD in Allogeneic Hematopoietic Stem Cell Transplantation: A Single-institute Analysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A bloodstream infection (BSI) is the most common serious infectious complication of hematopoietic stem cell transplantation (HSCT). BSI promotes an inflammatory state, which exacerbates acute graft-versus-host disease (GVHD). We investigated whether a Gram-negative rod bloodstream infection (GNR-BSI), which develops early after allo-HSCT, affected the onset or exacerbated acute GVHD in 465 patients who underwent allo-HSCT from 1995 through 2015 at a single institution. Eighty-eight patients (19%) developed BSI during the study period. Among the cultures, 50 (57%) were Gram-positive cocci (GPC) and 31 (35%) were GNR. Of the 465 patients, 187 (40%) developed acute GVHD of grade II or higher within the first 100 days post-allogeneic HSCT: 124 (27%) had acute GVHD grade II, 47 (10%) had grade III, and 16 (3%) had grade IV. Multivariate analysis revealed that GNR-BSI was a significant risk factor for grade II-IV acute GVHD (grade II-IV: hazard ratio [HR] 1.75, 95% confidence interval [CI] 1.03-2.97; grade III-IV: HR 2.37, 95% CI 1.03-5.43). These results suggest that GNR-BSI may predict the onset and exacerbation of acute GVHD.
en-copyright=
kn-copyright=

en-aut-name=NishinoharaMasa-aki
en-aut-sei=Nishinohara
en-aut-mei=Masa-aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishimoriHisakazu
en-aut-sei=Nishimori
en-aut-mei=Hisakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiwaraHideaki
en-aut-sei=Fujiwara
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AsadaNoboru
en-aut-sei=Asada
en-aut-mei=Noboru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=EnnishiDaisuke
en-aut-sei=Ennishi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsuokaKen-ichi
en-aut-sei=Matsuoka
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FujiiKeiko
en-aut-sei=Fujii
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=FujiiNobuharu
en-aut-sei=Fujii
en-aut-mei=Nobuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=blood stream infection
kn-keyword=blood stream infection
en-keyword=graft-versus-host disease
kn-keyword=graft-versus-host disease
en-keyword=gram negative rods
kn-keyword=gram negative rods
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=磁界結合型ワイヤレス給電の実用化を見据えた回路構成と制御指針に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaMasataka
en-aut-sei=Ishihara
en-aut-mei=Masataka
kn-aut-name=石原將貴
kn-aut-sei=石原
kn-aut-mei=將貴
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama university
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=胆管空腸吻合術後の肝内結石に対するバルーン内視鏡の治療成績
kn-title=Treatment outcomes, including risk factors of stone recurrence, for hepatolithiasis using balloon?assisted endoscopy in patients with hepaticojejunostomy (with video) 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaYuki
en-aut-sei=Ishihara
en-aut-mei=Yuki
kn-aut-name=石原裕基
kn-aut-sei=石原
kn-aut-mei=裕基
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=
article-no=
start-page=1196
end-page=1202
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202156
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Otorhinolaryngologists/head and neck surgeons’ knowledge, attitudes, and practices regarding fertility preservation in young cancer patients treated with chemotherapy: an anonymous questionnaire survey
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: It is well known that chemotherapy for adolescent and young adult (AYA) patients with cancer can reduce fertility regardless of the regimen. A decline in fertility greatly affects the quality of life of cancer survivors in the AYA age group; however, few patients are thought to be receiving fertility preservation measures.<br>
Methods: A questionnaire survey was conducted to assess the current understanding and consideration of fertility among otorhinolaryngologists/head and neck surgeons who treat AYA patients with cancer, and to inform them of the guidelines for fertility preservation. A total of 275 otorhinolaryngologists/head and neck surgeons working at our hospital in Ehime, Japan, six neighboring universities, and their affiliated facilities were included in this study. The questionnaire was mailed and requested to be returned by fax. Twenty questions were asked about respondents’ years of experience as physicians, specialties, experience in medical care and chemotherapy for AYA patients with cancer, and knowledge and experience in fertility reduction measures. <br>
Results: Although 58.7% of the physicians were aware that cryopreservation of eggs and sperm prior to chemotherapy was recommended, only 7 out of 40 physicians (17.5%) had referred AYA patients with cancer to an appropriate medical facility (department) after obtaining informed consent for chemotherapy.<br>
Conclusions: Although fertility preservation has been discussed at professional conferences and seminars, consideration and actions in the field of otorhinolaryngology/head and neck surgery have not been sufficient. We hope that the results of this survey will help raise awareness of fertility preservation.
en-copyright=
kn-copyright=

en-aut-name=AkisadaNaoki
en-aut-sei=Akisada
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MondenNobuya
en-aut-sei=Monden
en-aut-mei=Nobuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KishinoTakehito
en-aut-sei=Kishino
en-aut-mei=Takehito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AoiJiro
en-aut-sei=Aoi
en-aut-mei=Jiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HayashiYuji
en-aut-sei=Hayashi
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TakahashiSaori
en-aut-sei=Takahashi
en-aut-mei=Saori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakamuraMasataka
en-aut-sei=Nakamura
en-aut-mei=Masataka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshiharaHisashi
en-aut-sei=Ishihara
en-aut-mei=Hisashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NishizakiKazunori
en-aut-sei=Nishizaki
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=3
en-affil=Department of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=4
en-affil=Department of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=5
en-affil=Department of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=6
en-affil=Department of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=7
en-affil=Department of Head and Neck Surgery, National Hospital Organization Shikoku Cancer Center
kn-affil=

affil-num=8
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=

affil-num=9
en-affil=Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=fertility preservation
kn-keyword=fertility preservation
en-keyword=otorhinolaryngology
kn-keyword=otorhinolaryngology
en-keyword=head and neck cancer
kn-keyword=head and neck cancer
en-keyword=adolescent and young adult generation
kn-keyword=adolescent and young adult generation
en-keyword=guidelines
kn-keyword=guidelines
en-keyword=Japan
kn-keyword=Japan
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=376
end-page=382
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Swarming and mating behavior in Ephemera orientalis Mclachlan, 1875 (Ephemeroptera: Ephemeridae) with morphological analyses
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Swarming and mating behaviors of a mayfly species, Ephemera orientalis Mclachlan, 1875 were observed in 2015, 2016, and 2018 at a river bank of the Asahi River, Japan. Males started to make swarms between late April and middle May in 2016 and 2018. The numbers of mated pairs in a swarm correlated with the numbers of flying males in a swarm in 2016 and 2018. Swarms were formed during a limited period at dusk most probably because that interval is free from natural enemies. Males competed with each other to copulate with females in swarms. We clarified the function of the forelegs of males, which are significantly longer than those of females. Males used their forelegs to hold up a female from below. Besides forelegs, males have longer tails than females. We will discuss why sexual differences are found in these traits. Our results represent the first observation of swarm mating behavior in E. orientalis.
en-copyright=
kn-copyright=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugeTaichi
en-aut-sei=Suge
en-aut-mei=Taichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzakiShunsuke
en-aut-sei=Suzaki
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanabeShintaro
en-aut-sei=Tanabe
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshiharaRyo
en-aut-sei=Ishihara
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Aquatic insect
kn-keyword=Aquatic insect
en-keyword=Emergence
kn-keyword=Emergence
en-keyword=Copulation
kn-keyword=Copulation
en-keyword=Foreleg
kn-keyword=Foreleg
en-keyword=Mayfly
kn-keyword=Mayfly
en-keyword=Swarm
kn-keyword=Swarm
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=4
article-no=
start-page=811
end-page=830
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200415
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Factors associated with development and distribution of granular/fuzzy astrocytes in neurodegenerative diseases
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Granular/fuzzy astrocytes (GFAs), a subtype of “aging‐related tau astrogliopathy,” are noted in cases bearing various neurodegenerative diseases. However, the pathogenic significance of GFAs remains unclear. We immunohistochemically examined the frontal cortex, caudate nucleus, putamen and amygdala in 105 cases composed of argyrophilic grain disease cases (AGD, N = 26), and progressive supranuclear palsy (PSP, N = 10), Alzheimer’s disease (AD, N = 20) and primary age‐related tauopathy cases (PART, N = 18) lacking AGD, as well as 31 cases bearing other various neurodegenerative diseases to clarify (i) the distribution patterns of GFAs in AGD, and PSP, AD and PART lacking AGD, (ii) the impacts of major pathological factors and age on GFA formation and (iii) immunohistochemical features useful to understand the formation process of GFAs. In AGD cases, GFAs consistently occurred in the amygdala (100%), followed by the putamen (69.2%) and caudate nucleus and frontal cortex (57.7%, respectively). In PSP cases without AGD, GFAs were almost consistently noted in all regions examined (90?100%). In AD cases without AGD, GFAs were less frequent, developing preferably in the putamen (35.0%) and caudate nucleus (30.0%). PART cases without AGD had GFAs most frequently in the amygdala (35.3%), being more similar to AGD than to AD cases. Ordered logistic regression analyses using all cases demonstrated that the strongest independent factor of GFA formation in the frontal cortex and striatum was the diagnosis of PSP, while that in the amygdala was AGD. The age was not significantly associated with GFA formation in any region. In GFAs in AGD cases, phosphorylation and conformational change of tau, Gallyas‐positive glial threads indistinguishable from those in tufted astrocytes, and the activation of autophagy occurred sequentially. Given these findings, AGD, PSP, AD and PART cases may show distinct distributions of GFAs, which may provide clues to predict the underlying processes of primary tauopathies.
en-copyright=
kn-copyright=

en-aut-name=MikiTomoko
en-aut-sei=Miki
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YokotaOsamu
en-aut-sei=Yokota
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HaraguchiTakashi
en-aut-sei=Haraguchi
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshizuHideki
en-aut-sei=Ishizu
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HasegawaMasato
en-aut-sei=Hasegawa
en-aut-mei=Masato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=UenoShu‐ichi
en-aut-sei=Ueno
en-aut-mei=Shu‐ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakenoshitaShintaro
en-aut-sei=Takenoshita
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TeradaSeishi
en-aut-sei=Terada
en-aut-mei=Seishi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamadaNorihito
en-aut-sei=Yamada
en-aut-mei=Norihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Neurology, National Hospital Organization Minami‐Okayama Medical Center
kn-affil=

affil-num=4
en-affil=Department of Laboratory Medicine and Pathology, Zikei Institute of Psychiatry
kn-affil=

affil-num=5
en-affil=Dementia Research Project, Tokyo Metropolitan Institute of Medical Science
kn-affil=

affil-num=6
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=7
en-affil=Department of Neuropsychiatry, Ehime University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=aging‐related tau astrogliopathy
kn-keyword=aging‐related tau astrogliopathy
en-keyword=argyrophilic grain
kn-keyword=argyrophilic grain
en-keyword=granular/fuzzy astrocyte
kn-keyword=granular/fuzzy astrocyte
en-keyword=primary age‐related tauopathy
kn-keyword=primary age‐related tauopathy
en-keyword=tau
kn-keyword=tau
en-keyword=tufted astrocyte
kn-keyword=tufted astrocyte
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=6
article-no=
start-page=521
end-page=524
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Bilateral Approach for Thoracoscopic Esophagectomy in a Patient with Esophageal Cancer and Solitary Posterior Thoracic Para-aortic Lymph  Node Metastasis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report a successful dissection of metastatic posterior thoracic para-aortic lymph node (No. 112aoP) via bilateral thoracoscopic surgery. With the anesthetized patient (a 73-year-old Japanese woman) in the prone position, two working ports were inserted for the left-side approach, and artificial pneumothorax was created. Thoracoscopic examination revealed a swollen LN posterior to the descending aorta. Fat and metastatic LNs posterior to the aorta were dissected from the aortic arch level to the diaphragm while preserving intercostal arteries. For the right-side approach, two working ports were inserted and a routine thoracoscopic esophagec-tomy was performed. Gastric conduit reconstruction was achieved laparoscopically. Operation time for the left thoracic procedure: 54 min; estimated blood loss: almost none. No recurrence was detected 24 months post-operatively. There are several surgical options for approaching No. 112aoP, including transhiatal, left thora-cotomy, and thoracoscopy. Although a wide dissection of the posterior thoracic para-aortic area has not been reported, it may be feasible and safe if the artery of Adamkiewicz and intercostal arteries are preserved. A min-imally invasive bilateral thoracoscopic approach for a thoracoscopic esophagectomy is safe and useful for esophageal cancer patients with solitary No. 112aoP metastasis.
en-copyright=
kn-copyright=

en-aut-name=ItazakiYujiro
en-aut-sei=Itazaki
en-aut-mei=Yujiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TsujimotoHironori
en-aut-sei=Tsujimoto
en-aut-mei=Hironori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SugasawaHidekazu
en-aut-sei=Sugasawa
en-aut-mei=Hidekazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YaguchiYoshihisa
en-aut-sei=Yaguchi
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NomuraShinsuke
en-aut-sei=Nomura
en-aut-mei=Shinsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ItoNozomi
en-aut-sei=Ito
en-aut-mei=Nozomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HaradaManabu
en-aut-sei=Harada
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SugiharaTakao
en-aut-sei=Sugihara
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TsuchiyaSatoshi
en-aut-sei=Tsuchiya
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IshibashiYusuke
en-aut-sei=Ishibashi
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KouzuKeita
en-aut-sei=Kouzu
en-aut-mei=Keita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KishiYoji
en-aut-sei=Kishi
en-aut-mei=Yoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=UenoHideki 
en-aut-sei=Ueno
en-aut-mei=Hideki 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=2
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=3
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=4
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=5
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=6
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=7
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=8
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=9
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=10
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=11
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=12
en-affil=Department of Surgery, National Defense Medical College
kn-affil=

affil-num=13
en-affil=Department of Surgery, National Defense Medical College
kn-affil=
en-keyword=bilateral approach
kn-keyword=bilateral approach
en-keyword=posterior thoracic para-aortic lymph node
kn-keyword=posterior thoracic para-aortic lymph node
en-keyword=thoracoscopic esophagectomy
kn-keyword=thoracoscopic esophagectomy
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=102
end-page=114
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=2020
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies. Previous studies, using a pentylenetetrazole (PTZ)-induced kindling mouse model, showed that astrocyte activation and an increase in perineuronal nets (PNNs) and extracellular matrix (ECM) molecules occurred within the hippocampus. However, the mechanisms of initiation and suppression of these changes, remain unclear.</br>
Herein, we analyzed the attenuation of astrocyte activation caused by dizocilpine (MK-801) administration, as well as the anticonvulsant effect of α-pinene on seizures and production of ECM molecules. Our results showed that MK-801 significantly reduced kindling acquisition, while α-pinene treatment prevented an increase in seizures incidences. Both MK-801 and α-pinene administration attenuated astrocyte activation by PTZ and significantly attenuated the increase in ECM molecules.</br>
Our results indicate that astrocyte activation and an increase in ECM may contribute to epileptogenesis and suggest that MK-801 and α-pinene may prevent epileptic seizures by suppressing astrocyte activation and ECM molecule production.
en-copyright=
kn-copyright=

en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShimadaAtsumi
en-aut-sei=Shimada
en-aut-mei=Atsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakahashiYu
en-aut-sei=Takahashi
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare
kn-affil=

affil-num=2
en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College
kn-affil=

affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=7
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=8
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
en-keyword=Epilepsy
kn-keyword=Epilepsy
en-keyword=Kindling
kn-keyword=Kindling
en-keyword=Pentylenetetrazol
kn-keyword=Pentylenetetrazol
en-keyword=Perineuronal nets
kn-keyword=Perineuronal nets
en-keyword=Wisteria floribunda
kn-keyword=Wisteria floribunda
END

start-ver=1.4
cd-journal=joma
no-vol=113
cd-vols=
no-issue=
article-no=
start-page=33
end-page=41
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6?dependent Epilepsy Than Pyridoxal 5′-Phosphate
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background</br>
We aimed to demonstrate the biochemical characteristics of vitamin B6?dependent epilepsy, with a particular focus on pyridoxal 5′-phosphate and pyridoxal in the cerebrospinal fluid.</br>
Methods</br>
Using our laboratory database, we identified patients with vitamin B6?dependent epilepsy and extracted their data on the concentrations of pyridoxal 5′-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters. We compared the biochemical characteristics of these patients with those of other epilepsy patients with low pyridoxal 5′-phosphate concentrations.</br>
Results</br>
We identified seven patients with pyridoxine-dependent epilepsy caused by an ALDH7A1 gene abnormality, two patients with pyridoxal 5′-phosphate homeostasis protein deficiency, and 28 patients with other epilepsies with low cerebrospinal fluid pyridoxal 5′-phosphate concentrations. Cerebrospinal fluid pyridoxal and pyridoxal 5′-phosphate concentrations were low in patients with vitamin B6?dependent epilepsy but cerebrospinal fluid pyridoxal concentrations were not reduced in most patients with other epilepsies with low cerebrospinal fluid pyridoxal 5′-phosphate concentrations. Increase in 3-O-methyldopa and 5-hydroxytryptophan was demonstrated in some patients with vitamin B6?dependent epilepsy, suggestive of pyridoxal 5′-phosphate deficiency in the brain.</br>
Conclusions</br>
Low cerebrospinal fluid pyridoxal concentrations may be a better indicator of pyridoxal 5′-phosphate deficiency in the brain in vitamin B6?dependent epilepsy than low cerebrospinal fluid pyridoxal 5′-phosphate concentrations. This finding is especially helpful in individuals with suspected pyridoxal 5′-phosphate homeostasis protein deficiency, which does not have known biomarkers.
en-copyright=
kn-copyright=

en-aut-name=AkiyamaTomoyuki
en-aut-sei=Akiyama
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HyodoYuki
en-aut-sei=Hyodo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HasegawaKosei
en-aut-sei=Hasegawa
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OboshiTaikan
en-aut-sei=Oboshi
en-aut-mei=Taikan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ImaiKatsumi
en-aut-sei=Imai
en-aut-mei=Katsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshiharaNaoko
en-aut-sei=Ishihara
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=DowaYuri
en-aut-sei=Dowa
en-aut-mei=Yuri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KoikeTakayoshi
en-aut-sei=Koike
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamamotoToshiyuki
en-aut-sei=Yamamoto
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ShibasakiJun
en-aut-sei=Shibasaki
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=ShimboHiroko
en-aut-sei=Shimbo
en-aut-mei=Hiroko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=FukuyamaTetsuhiro
en-aut-sei=Fukuyama
en-aut-mei=Tetsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TakanoKyoko
en-aut-sei=Takano
en-aut-mei=Kyoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=ShirakuHiroshi
en-aut-sei=Shiraku
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=TakeshitaSaoko
en-aut-sei=Takeshita
en-aut-mei=Saoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=OkanishiTohru
en-aut-sei=Okanishi
en-aut-mei=Tohru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=BabaShimpei
en-aut-sei=Baba
en-aut-mei=Shimpei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=KubotaMasaya
en-aut-sei=Kubota
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=HamanoShin-ichiro
en-aut-sei=Hamano
en-aut-mei=Shin-ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=KobayashiKatsuhiro
en-aut-sei=Kobayashi
en-aut-mei=Katsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

affil-num=1
en-affil=Department of Child Neurology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Child Neurology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Pediatrics, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Pediatric Neurology, Osaka Women’s and Children’s Hospital
kn-affil=

affil-num=5
en-affil=Department of Pediatrics, NHO Shizuoka Institute of Epilepsy and Neurological Disorders
kn-affil=

affil-num=6
en-affil=Department of Pediatrics, Fujita Health University School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Neurology, Gunma Children’s Medical Center
kn-affil=

affil-num=8
en-affil=Department of Pediatrics, NHO Shizuoka Institute of Epilepsy and Neurological Disorders
kn-affil=

affil-num=9
en-affil=Institute of Clinical Genomics, Tokyo Women’s Medical University
kn-affil=

affil-num=10
en-affil=Department of Neonatology, Kanagawa Children’s Medical Center
kn-affil=

affil-num=11
en-affil=Clinical Institute, Kanagawa Children’s Medical Center
kn-affil=

affil-num=12
en-affil=Department of Pediatrics, Shinshu University
kn-affil=

affil-num=13
en-affil=Center for Medical Genetics, Shinshu University Hospital
kn-affil=

affil-num=14
en-affil=Department of Pediatrics, JA Toride Medical Center
kn-affil=

affil-num=15
en-affil=Department of Pediatrics, Yokohama City University Medical Center
kn-affil=

affil-num=16
en-affil=Department of Child Neurology, Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital
kn-affil=

affil-num=17
en-affil=Department of Child Neurology, Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital
kn-affil=

affil-num=18
en-affil=Division of Neurology, National Center for Child Health and Development
kn-affil=

affil-num=19
en-affil=Division of Neurology, Saitama Children’s Medical Center
kn-affil=

affil-num=20
en-affil=Department of Child Neurology, Okayama University Hospital
kn-affil=
en-keyword=ALDH7A1
kn-keyword=ALDH7A1
en-keyword=PLPBP
kn-keyword=PLPBP
en-keyword=PLPHP
kn-keyword=PLPHP
en-keyword=PROSC
kn-keyword=PROSC
en-keyword=Pyridoxal 5′-phosphate homeostasis protein deficiency
kn-keyword=Pyridoxal 5′-phosphate homeostasis protein deficiency
en-keyword=Pyridoxine-dependent epilepsy
kn-keyword=Pyridoxine-dependent epilepsy
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=
dt-pub=
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case report on refractory ulcerative stomatitis associated with acute lymphoblastic leukemia
kn-title=難治性潰瘍性口内炎を契機に判明した急性リンパ性白血病の 1 例
en-subtitle=
kn-subtitle=
en-abstract=We herein report a case on refractory ulcerative stomatitis associated with acute lymphoblastic leukemia. The female patient in her 60s showed refractory ulcer on her lower lip ; and the referral was made. Since pancytopenia was found by a blood test, hematologic disease was suspected. Bone marrow examination presented the diagnosis of Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia. Based on this diagnosis, steroid therapy had been initiated from four days after the first visit. On biopsy of lower lip, the pathological tissue did not show obvious infiltration of leukemia cells. Since oral manifestation may sometimes be an initial symptom of leukemia, an early diagnosis on leukemia patient with main complaint of oral symptom is critically important. Oral lesions, however, have various causes, and it thus often requires care of various clinical department. Based on this, it is considered to be important to implement treatment with cooperation among each clinical department.
kn-abstract=症例は難治性潰瘍性口内炎を契機に判明した急性リンパ性白血病の 1 例である．患者は 60 歳台，女性．下口唇に難治性潰瘍を認め紹介となった．血液検査にて汎血球減少を認めたため，血液疾患を疑った．骨髄検査にて，Ph 染色体陰性急性 B 細胞性リンパ性白血病と診断され，初診の 4 日後からステロイド療法が開始された．なお，下口唇生検の病理組織には明らかな白血病細胞の浸潤は認めなかった．口腔症状が白血病の初発症状となることがあり，これを主訴に受診した白血病患者を早期診断することは大変重要である．しかし，口腔病変の原因は多彩であり，さまざまな科が対応することが多く，各科が連携して診療にあたることが重要と考える．
en-copyright=
kn-copyright=

en-aut-name=IwakawaAsuka
en-aut-sei=Iwakawa
en-aut-mei=Asuka
kn-aut-name=岩川明日香
kn-aut-sei=岩川
kn-aut-mei=明日香
aut-affil-num=1
ORCID=

en-aut-name=KariyaAkifumi
en-aut-sei=Kariya
en-aut-mei=Akifumi
kn-aut-name=假谷彰文
kn-aut-sei=假谷
kn-aut-mei=彰文
aut-affil-num=2
ORCID=

en-aut-name=IshiharaHisashi
en-aut-sei=Ishihara
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=3
ORCID=

en-aut-name=AkisadaNaoki
en-aut-sei=Akisada
en-aut-mei=Naoki
kn-aut-name=秋定直樹
kn-aut-sei=秋定
kn-aut-mei=直樹
aut-affil-num=4
ORCID=

en-aut-name=FujiSayaka
en-aut-sei=Fuji
en-aut-mei=Sayaka
kn-aut-name=藤さやか
kn-aut-sei=藤
kn-aut-mei=さやか
aut-affil-num=5
ORCID=

en-aut-name=AkagiSeiko
en-aut-sei=Akagi
en-aut-mei=Seiko
kn-aut-name=赤木成子
kn-aut-sei=赤木
kn-aut-mei=成子
aut-affil-num=6
ORCID=

en-aut-name=UmayaharaTakatsune
en-aut-sei=Umayahara
en-aut-mei=Takatsune
kn-aut-name=馬屋原孝恒
kn-aut-sei=馬屋原
kn-aut-mei=孝恒
aut-affil-num=7
ORCID=

en-aut-name=TamuraMaiko
en-aut-sei=Tamura
en-aut-mei=Maiko
kn-aut-name=田村麻衣子
kn-aut-sei=田村
kn-aut-mei=麻衣子
aut-affil-num=8
ORCID=

en-aut-name=TakeuchiMakoto
en-aut-sei=Takeuchi
en-aut-mei=Makoto
kn-aut-name=竹内誠
kn-aut-sei=竹内
kn-aut-mei=誠
aut-affil-num=9
ORCID=

en-aut-name=TakeuchiAyako
en-aut-sei=Takeuchi
en-aut-mei=Ayako
kn-aut-name=竹内彩子
kn-aut-sei=竹内
kn-aut-mei=彩子
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Center for Graduate Medical Education, Okayama University Hospital
kn-affil=岡山大学病院　卒後臨床研修センター

affil-num=2
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科

affil-num=3
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科

affil-num=4
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科

affil-num=5
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科

affil-num=6
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科

affil-num=7
en-affil=Department of Dermatology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　皮膚科

affil-num=8
en-affil=Department of Pathological Diagnosis, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　病理診断科

affil-num=9
en-affil=Department of Hematology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　血液内科

affil-num=10
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科
en-keyword=oral manifestations
kn-keyword=oral manifestations
en-keyword=leukemia
kn-keyword=leukemia
en-keyword=oral ulcer
kn-keyword=oral ulcer
en-keyword=initial symptoms
kn-keyword=initial symptoms
en-keyword=otolaryngology
kn-keyword=otolaryngology
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
article-no=
start-page=e10244
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201109
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background</br>
In this study, we investigated the effect of the mechanical loading history on the expression of receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in MLO-Y4 osteocyte-like cells.</br>
Methods</br>
Three hours after MLO-Y4 osteocytes were seeded, a continuous compressive force (CCF) of 31 dynes/cm2 with or without additional CCF (32 dynes/cm2) was loaded onto the osteocytes. After 36 h, the additional CCF (loading history) was removed for a recovery period of 10 h. The expression of RANKL, OPG, RANKL/OPG ratio, cell numbers, viability and morphology were time-dependently examined at 0, 3, 6 and 10 h. Then, the same additional CCF was applied again for 1 h to all osteocytes with or without the gap junction inhibitor to examine the expression of RANKL, OPG, the RANKL/OPG ratio and other genes that essential to characterize the phenotype of MLO-Y4 cells. Fluorescence recovery after photobleaching technique was also applied to test the differences of gap-junctional intercellular communications (GJIC) among MLO-Y4 cells.</br>
Results</br>
The expression of RANKL and OPG by MLO-Y4 osteocytes without a loading history was dramatically decreased and increased, respectively, in response to the 1-h loading of additional weight. However, the expression of RANKL, OPG and the RANKL/OPG ratio were maintained at the same level as in the control group in the MLO-Y4 osteocytes with a loading history but without gap junction inhibitor treatment. Treatment of loading history significantly changed the capacity of GJIC and protein expression of connexin 43 (Cx43) but not the mRNA expression of Cx43. No significant difference was observed in the cell number or viability between the MLO-Y4 osteocyte-like cells with and without a loading history or among different time checkpoints during the recovery period. The cell morphology showed significant changes and was correlated with the expression of OPG, Gja1 and Dmp1 during the recovery period.</br>
Conclusion</br>
Our findings indicated that the compressive force-induced changes in the RANKL/OPG expression could be habituated within at least 11 h by 36-h CCF exposure. GJIC and cell morphology may play roles in response to loading history in MLO-Y4 osteocyte-like cells.
en-copyright=
kn-copyright=

en-aut-name=WangZiyi
en-aut-sei=Wang
en-aut-mei=Ziyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WengYao
en-aut-sei=Weng
en-aut-mei=Yao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OdagakiNaoya
en-aut-sei=Odagaki
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HlaingEi Ei Hsu
en-aut-sei=Hlaing
en-aut-mei=Ei Ei Hsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IzawaTakashi
en-aut-sei=Izawa
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkamuraHirohiko
en-aut-sei=Okamura
en-aut-mei=Hirohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral Morphology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Osteocytes
kn-keyword=Osteocytes
en-keyword=Habituation
kn-keyword=Habituation
en-keyword=18 alpha-Glycyrrhetinic acid
kn-keyword=18 alpha-Glycyrrhetinic acid
en-keyword=Fluorescence recovery after photobleaching
kn-keyword=Fluorescence recovery after photobleaching
en-keyword=Gap junctional intercellular communication
kn-keyword=Gap junctional intercellular communication
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=10
article-no=
start-page=e1009091
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201028
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Exploring the Complexity of Protein-Level Dosage Compensation that Fine-Tunes Stoichiometry of Multiprotein Complexes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Proper control of gene expression levels upon various perturbations is a fundamental aspect of cellular robustness. Protein-level dosage compensation is one mechanism buffering perturbations to stoichiometry of multiprotein complexes through accelerated proteolysis of unassembled subunits. Although N-terminal acetylation- and ubiquitin-mediated proteasomal degradation by the Ac/N-end rule pathway enables selective compensation of excess subunits, it is unclear how widespread this pathway contributes to stoichiometry control. Here we report that dosage compensation depends only partially on the Ac/N-end rule pathway. Our analysis of genetic interactions between 18 subunits and 12 quality control factors in budding yeast demonstrated that multiple E3 ubiquitin ligases and N-acetyltransferases are involved in dosage compensation. We find that N-acetyltransferases-mediated compensation is not simply predictable from N-terminal sequence despite their sequence specificity for N-acetylation. We also find that the compensation of Pop3 and Bet4 is due in large part to a minor N-acetyltransferase NatD. Furthermore, canonical NatD substrates histone H2A/H4 were compensated even in its absence, suggesting N-acetylation-independent stoichiometry control. Our study reveals the complexity and robustness of the stoichiometry control system. Author summary Quality control of multiprotein complexes is important for maintaining homeostasis in cellular systems that are based on functional complexes. Proper stoichiometry of multiprotein complexes is achieved by the balance between protein synthesis and degradation. Recent studies showed that translation efficiency tends to scale with stoichiometry of their subunits. On the other hand, although protein N-terminal acetylation- and ubiquitin-mediated proteolysis pathway is involved in selective degradation of excess subunits, it is unclear how widespread this pathway contributes to stoichiometry control due to the lack of a systematic investigation using endogenous proteins. To better understand the landscape of the stoichiometry control system, we examined genetic interactions between 18 subunits and 12 quality control factors (E3 ubiquitin ligases and N-acetyltransferases), in total 114 combinations. Our data suggest that N-acetyltransferases are partially responsible for stoichiometry control and that N-acetylation-independent pathway is also involved in selective degradation of excess subunits. Therefore, this study reveals the complexity and robustness of the stoichiometry control system. Further dissection of this complexity will help to understand the mechanisms buffering gene expression perturbations and shaping proteome stoichiometry.
en-copyright=
kn-copyright=

en-aut-name=IshikawaKoji
en-aut-sei=Ishikawa
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaAkari
en-aut-sei=Ishihara
en-aut-mei=Akari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MoriyaHisao
en-aut-sei=Moriya
en-aut-mei=Hisao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Course of Agrochemical Bioscience, Faculty of Agriculture, Okayama University
kn-affil=

affil-num=3
en-affil= Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=
article-no=
start-page=1895
end-page=1902
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201102
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Treatment outcomes, including risk factors of stone recurrence, for hepatolithiasis using balloon-assisted endoscopy in patients with hepaticojejunostomy (with video)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background and study aimsa</br>
Endoscopic treatment outcomes for hepatolithiasis in patients with altered anatomy are not well known. The aim of this study was to evaluate the treatment outcomes of hepatolithiasis in patients with hepaticojejunostomy (HJ) using short-type double-balloon endoscopy (sDBE) and to assess the risk factors for stone recurrence.</br>
Patients and methods</br>
This was a retrospective cohort study that consisted of 73 patients with hepatolithiasis who underwent bowel reconstruction with HJ at an academic center. Stone removal was performed using sDBE. After balloon-occluded cholangiography using sDBE, peroral direct cholangioscopy (PDCS) using ultraslim endoscopy was performed to check for residual stones, depending on the bowel reconstruction method. Recurrence was defined as the development of cholangitis from stones.</br>
Results</br>
The success rate of reaching the HJ site was 92% (67/73), and the complete stone removal rate was 93% (62/67) with multiple sessions (mean number 1.5?±?0.9). The occurrence rate of procedure-related adverse events was 6.8%. Among 58 patients evaluated for stone recurrence, 13 (22%) developed recurrence during a median follow-up period of 2.7 years (interquartile range: 1.5?4.8). Multivariate analyses determined that a stone diameter???8 mm [odds ratio (OR), 5.57; 95% confidence interval (CI), 1.39?37.2; p?=?0.013] and performing PDCS (OR, 0.16; 95% CI, 0.0084?0.90; p?=?0.036) were significant factors for stone recurrence.</br>
Conclusions</br>
Endoscopic treatment using sDBE for hepatolithiasis was effective and safe. PDCS might reduce the rate of stone recurrence by detecting stones that are too small to confirm on fluoroscopic images.
en-copyright=
kn-copyright=

en-aut-name=IshiharaYuki
en-aut-sei=Ishihara
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoKazuyuki
en-aut-sei=Matsumoto
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsutsumiKoichiro
en-aut-sei=Tsutsumi
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TomodaTakeshi
en-aut-sei=Tomoda
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsumiAkihiro
en-aut-sei=Matsumi
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyamotoKazuya
en-aut-sei=Miyamoto
en-aut-mei=Kazuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YamazakiTatsuhiro
en-aut-sei=Yamazaki
en-aut-mei=Tatsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SaragaiYosuke
en-aut-sei=Saragai
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=FujiiYuki
en-aut-sei=Fujii
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=UchidaDaisuke
en-aut-sei=Uchida
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HoriguchiShigeru
en-aut-sei=Horiguchi
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=13
en-affil=Department of Gastroenterology and Hepatology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=Peroral direct cholangioscopy
kn-keyword=Peroral direct cholangioscopy
en-keyword=Hepatolithiasis
kn-keyword=Hepatolithiasis
en-keyword=Altered gastrointestinal anatomy
kn-keyword=Altered gastrointestinal anatomy
en-keyword=Double-balloon endoscopy
kn-keyword=Double-balloon endoscopy
END

start-ver=1.4
cd-journal=joma
no-vol=39
cd-vols=
no-issue=
article-no=
start-page=107
end-page=113
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20201020
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Arousal from death feigning by vibrational stimuli: comparison of Tribolium species
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Death feigning (or tonic immobility) is an effective antipredator strategy. However, prolonged immobility on the ground increases the risk of being parasitized or eaten by predators, and thus, insects must rouse themselves when appropriate stimulation is provided. Very few studies on the effect of stimulus intensity on arousal from death feigning have been conducted. A previous study using Tribolium castaneum showed an existing threshold for the intensity of the stimulus that causes arousal from death feigning. Whether there are differences between species in the threshold for arousal is an interesting question. In the present study, we, therefore, compared the effect of stimulus strength on arousal from death feigning in two closely related species, namely, T. confusum and T. freemani, which are established strains that have been artificially selected for longer duration of death feigning. Also, part of the study was to determine whether there was a positive association between intensity of stimulus needed to rouse and the duration of death feigning. We discuss why there is a difference in the strength of the stimulus needed for arousal from death feigning among Tribolium species, for which we included the data for T. castaneum from a previous study.
en-copyright=
kn-copyright=

en-aut-name=IshiharaRyo
en-aut-sei=Ishihara
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumuraKentarou
en-aut-sei=Matsumura
en-aut-mei=Kentarou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=JonesJordan Elouise
en-aut-sei=Jones
en-aut-mei=Jordan Elouise
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YuhaoJi
en-aut-sei=Yuhao
en-aut-mei=Ji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujisawaRyusuke
en-aut-sei=Fujisawa
en-aut-mei=Ryusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NagayaNaohisa
en-aut-sei=Nagaya
en-aut-mei=Naohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Evolutionary Ecology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Evolutionary Ecology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool
kn-affil=

affil-num=4
en-affil=Department of Evolutionary Ecology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=School of Computer Science and Systems Engineering, Kyushu Institute of Technology
kn-affil=

affil-num=6
en-affil=Faculty of Information Science and Engineering, Kyoto Sangyo University
kn-affil=

affil-num=7
en-affil=Department of Evolutionary Ecology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Beetle
kn-keyword=Beetle
en-keyword=Death feigning
kn-keyword=Death feigning
en-keyword=Selection experiment
kn-keyword=Selection experiment
en-keyword=Species comparison
kn-keyword=Species comparison
en-keyword=Thanatosis
kn-keyword=Thanatosis
en-keyword=Tonic immobility
kn-keyword=Tonic immobility
en-keyword=Tribolium
kn-keyword=Tribolium
END

start-ver=1.4
cd-journal=joma
no-vol=39
cd-vols=
no-issue=
article-no=
start-page=148
end-page=159
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200825
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Introduction</br>
Mechanical stimuli regulate Sclerostin (Scl), a negative regulator of bone formation, expression in osteocytes. However, the detailed Scl distribution in osteocytes in response to mechanical unloading remains unclear.</br>
Materials and methods</br>
Twelve-week-old male rats were used. The sciatic and femoral nerves on the right side were excised as mechanical unloading treatment. A sham operation was performed on the left side. One week after neurotrauma, the bone density of the femora was evaluated by peripheral quantitative computed tomography, and immunofluorescence was performed in coronal sections of the femoral diaphysis. The mean fluorescence intensity and fluorescent profile of Scl from the marrow to the periosteal side were analyzed to estimate the Scl expression and determine to which side (marrow or periosteal) the Scl prefers to distribute in response to mechanical unloading. The most sensitive region indicated by the immunofluorescence results was further investigated by transmission electron microscopy (TEM) with immunogold staining to show the Scl expression changes in different subcellular structures.</br>
Results</br>
In femur distal metaphysis, neurotrauma-induced mechanical unloading significantly decreased the bone density, made the distribution of Scl closer to the marrow on the anterior and medial side, and increased the Scl expression only on the lateral side. TEM findings showed that only the expression of Scl in canaliculi was increased by mechanical unloading.</br>
Conclusions</br>
Our results showed that even short-term mechanical unloading is enough to decrease bone density, and mechanical unloading not only regulated the Scl expression but also changed the Scl distribution in both the osteocyte network and subcellular structures.
en-copyright=
kn-copyright=

en-aut-name=OsumiRyuta
en-aut-sei=Osumi
en-aut-mei=Ryuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WangZiyi
en-aut-sei=Wang
en-aut-mei=Ziyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OdagakiNaoya
en-aut-sei=Odagaki
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IimuraTadahiro
en-aut-sei=Iimura
en-aut-mei=Tadahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Pharmacology, Graduate School of Dental Medicine, Hokkaido University
kn-affil=

affil-num=6
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Sclerostin distribution
kn-keyword=Sclerostin distribution
en-keyword=Lacuno-canalicular system
kn-keyword=Lacuno-canalicular system
en-keyword=Mechanical unloading
kn-keyword=Mechanical unloading
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=5
article-no=
start-page=652
end-page=658
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=2020
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Utility of Endoscopic Ultrasound-Guided Fine Needle Aspiration in the Diagnosis of Local Recurrence of Pancreaticobiliary Cancer after Surgical Resection
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background/Aims: Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA; EUS-FNA) allows for diagnostic tissue specimens from various regions to be analyzed. However, diagnosing recurrent pancreaticobiliary cancer after surgery is sometimes difficult. We evaluated the efficacy of EUS-FNA in the diagnosis of local recurrence of pancreaticobiliary cancer and analyzed the factors associated with falsenegative results. Methods: Fifty-one consecutive patients who underwent EUS-FNA due to suspected recurrence of pancreaticobiliary cancer after surgery in an academic center were retrospectively analyzed. The criteria for EUS-FNA were a resected margin or remnant pancreas mass, round swollen lymph node (?10 mm in diameter), and soft-tissue enhancement around a major artery. Patients with suspected liver metastasis or malignant ascites were excluded. Results: Thirty-nine of the 51 patients had pancreatic cancer; the remaining 12 had biliary cancer. The target sites for EUS-FNA were the soft tissue around a major artery (n=22, 43%), the resected margin or remnant pancreas (n=12, 24%), and the lymph nodes (n=17, 33%). The median size of the suspected recurrent lesions was 15 mm (range, 8 to 40 mm). The overall sensitivity, specificity and accuracy of EUS-FNA for the diagnosis of recurrence was 84% (32/38), 100% (13/13), and 88% (45/51), respectively. FNA of the soft tissue around major arteries (odds ratio, 8.23; 95% confidence interval, 1.2 to 166.7; p=0.033) was significantly associated with a falsenegative diagnosis in the multivariate analysis. Conclusions: EUS-FNA is useful for diagnosing recurrent cancer, even after pancreaticobiliary surgery. The diagnoses of recurrence at soft-tissue sites should be interpreted with caution.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoKazuyuki
en-aut-sei=Matsumoto
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HoriguchiShigeru
en-aut-sei=Horiguchi
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TomodaTakeshi
en-aut-sei=Tomoda
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsumiAkihiro
en-aut-sei=Matsumi
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshiharaYuki
en-aut-sei=Ishihara
en-aut-mei=Yuki
kn-aut-name= 
kn-aut-sei= 
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SaragaiYosuke
en-aut-sei=Saragai
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakadaSaimon
en-aut-sei=Takada
en-aut-mei=Saimon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MuroShinichiro
en-aut-sei=Muro
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=UchidaDaisuke
en-aut-sei=Uchida
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=
en-keyword=Endoscopic ultrasound-guided fine needle aspiration
kn-keyword=Endoscopic ultrasound-guided fine needle aspiration
en-keyword=Pancreaticobiliary cancer
kn-keyword=Pancreaticobiliary cancer
en-keyword=Neoplasm recurrence
kn-keyword=Neoplasm recurrence
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=1
article-no=
start-page=12
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200602
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Occlusal reconstruction of a patient with ameloblastoma ablation using alveolar distraction osteogenesis: a case report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Ameloblastoma is one of the most common benign odontogenic neoplasms. Its surgical excision has the potential to lead to postoperative malocclusion. In this case report, we describe the successful interdisciplinary orthodontic treatment of a patient with ameloblastoma who underwent marginal mandibulectomy. Case presentation A woman of 20-year-old was diagnosed with ameloblastoma, and underwent marginal mandibulectomy when she was 8 years of age. She had an excessive overjet (11.5 mm) and a mild open bite (- 1.5 mm) with a severely resorbed atrophic edentulous ridge in the area around the mandibular left lateral incisor, canine and first premolar. An alveolar bone defect associated with tumor resection was regenerated by vertical distraction osteogenesis (DO). Subsequently, 3 dental implants were placed into the reconstructed mandible. Orthodontic treatment using implant-anchored mechanics provided a proper facial profile with significantly improved occlusal function. The occlusion appeared stable for a 7-year retention period. Conclusions These results suggest that surgically assisted and implant anchored-orthodontic approaches might be effective for the correction of such malocclusions.	
en-copyright=
kn-copyright=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ArakawaHikaru
en-aut-sei=Arakawa
en-aut-mei=Hikaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishiyamaAkiyoshi
en-aut-sei=Nishiyama
en-aut-mei=Akiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Okayama University Graduate School of Medicine Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Ameloblastoma
kn-keyword=Ameloblastoma
en-keyword=Alveolar distraction osteogenesis
kn-keyword=Alveolar distraction osteogenesis
en-keyword=Implant anchorage
kn-keyword=Implant anchorage
en-keyword=Postoperative malocclusion
kn-keyword=Postoperative malocclusion
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=3
article-no=
start-page=245
end-page=250
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of Vonoprazan on Delayed Bleeding after Endoscopic Submucosal Dissection for Gastric Neoplasia among Antithrombotic Drug Users: A Single-Center, Single-Arm Prospective Observational Case Control Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Antithrombotic therapy is a major risk factor for delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasia. A potassium-competitive acid blocker, vonoprazan, is expected to prevent delayed bleeding better than conventional proton pomp inhibitors (PPIs), but the evidence is controversial. We sought to clarify the efficacy of vonoprazan for prevention of delayed bleeding after gastric ESD in patients under antithrombotic therapy. We prospectively registered 50 patients who underwent gastric ESD while receiving antithrombotic therapy and vonoprazan in our institution between October 2017 and September 2018. The incidence of delayed bleeding was compared with that in a historical control group of 116 patients treated with conventional PPI. We also evaluated risk factors associated with delayed bleeding. Delayed bleeding was observed in 8 of 50 patients (16.0%), which was not dissimilar from the incidence in the historical control group (12.1%) (p=0.49). In the univariate analysis, age (> 70 years) (p=0.034), multiple antithrombotic drug use (p<0.01), procedure time (> 200 min) (p=0.038) and tumor size (> 40 mm) (p<0.01) were associated with delayed bleeding after gastric ESD, but vonoprazan was not (p=0.49). Vonoprazan may not be more effective than conventional PPIs in preventing delayed bleeding after gastric ESD in patients receiving antithrombotic therapy.
en-copyright=
kn-copyright=

en-aut-name=YamamotoShumpei
en-aut-sei=Yamamoto
en-aut-mei=Shumpei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakayamaHiroshi
en-aut-sei=Takayama
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShimodateYuichi
en-aut-sei=Shimodate
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakezawaRio
en-aut-sei=Takezawa
en-aut-mei=Rio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishimuraNaoyuki
en-aut-sei=Nishimura
en-aut-mei=Naoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=DoiAkira
en-aut-sei=Doi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MouriHirokazu
en-aut-sei=Mouri
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatsuedaKazuhiro
en-aut-sei=Matsueda
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MizunoMotowo
en-aut-sei=Mizuno
en-aut-mei=Motowo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Kurashiki Central Hospital
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=vonoprazan
kn-keyword=vonoprazan
en-keyword=endoscopic submucosal dissection
kn-keyword=endoscopic submucosal dissection
en-keyword=antithrombotic drug
kn-keyword=antithrombotic drug
en-keyword=gastric cancer
kn-keyword=gastric cancer
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=9
article-no=
start-page=10409
end-page=10424
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201909
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Role of intracellular Ca2+?based mechanotransduction of human periodontal ligament fibroblasts
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Human periodontal ligament (hPDL) fibroblasts are thought to receive mechanical stress (MS) produced by orthodontic tooth movement, thereby regulating alveolar bone remodeling. However, the role of intracellular calcium ([Ca2+]i)‐based mechanotransduction is not fully understood. We explored the MS‐induced [Ca2+]i responses both in isolated hPDL fibroblasts and in intact hPDL tissue and investigated its possible role in alveolar bone remodeling. hPDL fibroblasts were obtained from healthy donors' premolars that had been extracted for orthodontic reasons. The oscillatory [Ca2+]i activity induced by static compressive force was measured by a live‐cell Ca2+ imaging system and evaluated by several feature extraction method. The spatial pattern of cell‐cell communication was investigated by Moran's I , an index of spatial autocorrelation and the gap junction (GJ) inhibitor. The Ca2+‐transporting ionophore A23187 was used to further investigate the role of [Ca2+]i up‐regulation in hPDL cell behavior. hPDL fibroblasts displayed autonomous [Ca2+]i responses. Compressive MS activated this autonomous responsive behavior with an increased percentage of responsive cells both in vitro and ex vivo . The integration, variance, maximum amplitude, waveform length, and index J in the [Ca2+]i responses were also significantly increased, whereas the mean power frequency was attenuated in response to MS. The increased Moran's I after MS indicated that MS might affect the pattern of cell‐cell communication via GJs. Similar to the findings of MS‐mediated regulation, the A23187‐mediated [Ca2+]i uptake resulted in the up‐regulation of receptor activator of NF‐κB ligand (Rankl) and Sost along with increased sclerostin immunoreactivity, suggesting that [Ca2+]i signaling networks may be involved in bone remodeling. In addition, A23187‐treated hPDL fibroblasts also showed the suppression of osteogenic differentiation and mineralization. Our findings suggest that augmented MS‐mediated [Ca2+]i oscillations in hPDL fibroblasts enhance the production and release of bone regulatory signals via Rankl/Osteoprotegerin and the canonical Wnt/β‐catenin pathway as an early process in tooth movement?initiated alveolar bone remodeling.?Ei Hsu Hlaing, E., Ishihara, Y., Wang, Z., Odagaki, N., Kamioka, H. Role of intracellular Ca2+‐based mechanotransduction of human periodontal ligament fibroblasts. FASEB J. 33, 10409?10424 (2019).
en-copyright=
kn-copyright=

en-aut-name=HlaingEi Ei Hsu
en-aut-sei=Hlaing
en-aut-mei=Ei Ei Hsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangZiyi
en-aut-sei=Wang
en-aut-mei=Ziyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OdagakiNaoya
en-aut-sei=Odagaki
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=hPDL
kn-keyword=hPDL
en-keyword=intracellular calcium
kn-keyword=intracellular calcium
en-keyword=SOST/sclerostin
kn-keyword=SOST/sclerostin
en-keyword=Rankl/Opg
kn-keyword=Rankl/Opg
en-keyword=bone remodeling
kn-keyword=bone remodeling
END

start-ver=1.4
cd-journal=joma
no-vol=38
cd-vols=
no-issue=
article-no=
start-page=233
end-page=239
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200314
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Relationships between mating tactics and male traits such as body size and fluctuating asymmetry in the Japanese scorpionfly
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fluctuating asymmetry (FA) is defined as small, random deviations from perfect bilateral symmetry in a morphological trait. It has sometimes been used as an indicator of male quality because it affects male mating success. In the Japanese scorpionfly, Panorpa japonica, males are known to use two mating tactics, donation of nuptial gifts and forced mating. In P. japonica, low FA males are more likely to win a competition with another male, and females prefer low FA male sex pheromones. However, no studies have been conducted on the effect of FA on the mating tactics adopted by males. In the present study, we first observed the mating behaviors of P. japonica and classified these into three patterns: (1) nuptial gifting, (2) forced mating, and (3) feeding mating. Second, we investigated the relationships between mating tactics and male traits, including body size, FA, and weapon size. The results showed a positive correlation between absolute FA and mating duration only in the case of feeding mating. We discuss the reasons why this significant correlation was found in P. japonica.
en-copyright=
kn-copyright=

en-aut-name=IshiharaRyo
en-aut-sei=Ishihara
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyatakeTakahisa
en-aut-sei=Miyatake
en-aut-mei=Takahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=raduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=
en-keyword=Copulation
kn-keyword=Copulation
en-keyword=Courtship
kn-keyword=Courtship
en-keyword=Mating duration
kn-keyword=Mating duration
en-keyword=Panorpa japonica
kn-keyword=Panorpa japonica
END

start-ver=1.4
cd-journal=joma
no-vol=141
cd-vols=
no-issue=25
article-no=
start-page=9832
end-page=9836
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019611
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Deoxygenative Insertion of Carbonyl Carbon into a C(sp3)?H Bond: Synthesis of Indolines and Indoles
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A simple deoxygenation reagent prepared in situ from commercially available Mo(CO)6 and ortho-quinone has been developed for the synthesis of indoline and indole derivatives. The Mo/quinone complex efficiently deoxygenates carbonyl compounds bearing a neighboring dialkylamino group and effects intramolecular cyclizations with the insertion of a deoxygenated carbonyl carbon into a C(sp3)?H bond, in which a carbonyl group acts as a carbene equivalent. The reaction also proceeds with a catalytic amount of Mo/quinone in the presence of disilane as an oxygen atom acceptor.
en-copyright=
kn-copyright=

en-aut-name=AsakoSobi
en-aut-sei=Asako
en-aut-mei=Sobi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaSeina
en-aut-sei=Ishihara
en-aut-mei=Seina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HirataKeiya
en-aut-sei=Hirata
en-aut-mei=Keiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakaiKazuhiko
en-aut-sei=Takai
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=C-H activation
kn-keyword=C-H activation
en-keyword=Oxidative addition
kn-keyword=Oxidative addition
en-keyword=Structural-characterization
kn-keyword=Structural-characterization
en-keyword=Ditungsten hexaalkoxides
kn-keyword=Ditungsten hexaalkoxides
en-keyword=Direct functionalization
kn-keyword=Direct functionalization
en-keyword=Organic-synthesis
kn-keyword=Organic-synthesis
en-keyword=Tertiary-amines
kn-keyword=Tertiary-amines
en-keyword=Oxo-alkylidene
kn-keyword=Oxo-alkylidene
en-keyword=Ketones
kn-keyword=Ketones
en-keyword=Chemistry
kn-keyword=Chemistry
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=河道湾曲部における横越流量公式に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaMasayoshi
en-aut-sei=Ishihara
en-aut-mei=Masayoshi
kn-aut-name=石原正義
kn-aut-sei=石原
kn-aut-mei=正義
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=2
article-no=
start-page=137
end-page=143
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mucinous Carcinoma of the Breast: Clinicopathological Features and Long-term Prognosis in Comparison with Invasive Ductal Cancer; A Single Hospital’s 30+-Year Experience
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Mucinous carcinoma (MC) of the breast is a rare and special type of malignancy, with a substantial amount of extracellular mucin. We compared the clinicopathological features and the long-term survival of MC patients with those of invasive ductal carcinoma-no special type (IDC-NST) patients, and we examined prognostic factors of MC. A total of 116 patients with mucinous carcinoma and 3,258 patients with IDC-NST who underwent surgery at our hospital (1977-2008) were enrolled. The 10-year overall survival rate and breast cancer-specific survival rate (BSS) of the MC patients (88.3%, 93.7%) were both significantly higher than those of IDC-NST patients (81.6%, 85.0%) (p=0.015, p=0.005, respectively). A Cox regression analysis demonstrated that MC tended to be an independent prognostic factor (hazard ratio 0.44, p=0.098). The BSS of the MC patients with positive lymph node (LN) metastasis was significantly poorer than that of the patients without it, by univariate analysis (p=0.002). The tumor size in the MC patients with positive LN metastasis (mean 3.2 cm) was significantly larger than that in the patients without it (mean 1.9 cm) (p=0.0004). Although a Cox regression analysis revealed no independent factor, MC patients with positive LN metastasis should be treated for advanced invasive ductal breast cancer.
en-copyright=
kn-copyright=

en-aut-name=IsozakiHiroshi
en-aut-sei=Isozaki
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoYasuhisa
en-aut-sei=Yamamoto
en-aut-mei=Yasuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SakaiKunihiko
en-aut-sei=Sakai
en-aut-mei=Kunihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShoTatuo
en-aut-sei=Sho
en-aut-mei=Tatuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshiharaKiyohiro
en-aut-sei=Ishihara
en-aut-mei=Kiyohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurakamiShigeki
en-aut-sei=Murakami
en-aut-mei=Shigeki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsumotoSasau
en-aut-sei=Matsumoto
en-aut-mei=Sasau
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakamaTakehiro
en-aut-sei=Takama
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Surgery, Oomoto Hospital
kn-affil=

affil-num=2
en-affil=Department of Surgery, Oomoto Hospital
kn-affil=

affil-num=3
en-affil=Department of Surgery, Oomoto Hospital
kn-affil=

affil-num=4
en-affil=Department of Surgery, Oomoto Hospital
kn-affil=

affil-num=5
en-affil=Department of Surgery, Oomoto Hospital
kn-affil=

affil-num=6
en-affil=Department of Surgery, Oomoto Hospital
kn-affil=

affil-num=7
en-affil=Department of Surgery, Oomoto Hospital
kn-affil=

affil-num=8
en-affil=Department of Surgery, Oomoto Hospital
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=mucinous carcinoma
kn-keyword=mucinous carcinoma
en-keyword=clinicopathological features
kn-keyword=clinicopathological features
en-keyword=long-term prognosis
kn-keyword=long-term prognosis
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=145
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Emergency medical treatment of patients undergoing otolaryngology in the southeastern part of Okayama Prefecture
kn-title=岡山県南東部における夜間・休日の耳鼻咽喉科救急診療の実状
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the scenario regarding the emergency medical treatment of patients undergoing otolaryngology in southeastern Okayama Prefecture in Japan, we evaluated the conditions in three hospitals that mainly provide emergency medical treatment to patients undergoing otorhinolaryngology at night or on holidays. The data (age, sex, type of disease, and address) of patients who visited Japanese Red Cross Okayama Hospital, Kawasaki Medical School General Medical Center, and Okayama Medical Center in 2018 were collected and compared. All three hospitals reported many cases of tonsillar abscess and nasal bleeding. In the study population, the number of patients aged ?10 and 10-20 years were the lowest and highest, respectively. Patients residing in southern Okayama City and Tamano City tended to visit Japanese Red Cross Okayama Hospital or Kawasaki Medical School General Medical Center. Patients residing in northeastern Okayama Prefecture and northern Okayama City tended to visit Okayama Medical Center. A ceiling for the senior physicians’ capacity will be introduced in April 2020, and thus the number of otolaryngology-related treatments performed in Okayama Prefecture is expected to decrease. The otolaryngologyrelated emergency medical treatment in southeastern Okayama Prefecture may collapse. Emergency medical care systems must therefore be considered in the future.
en-copyright=
kn-copyright=

en-aut-name=AkisadaNaoki
en-aut-sei=Akisada
en-aut-mei=Naoki
kn-aut-name=秋定直樹
kn-aut-sei=秋定
kn-aut-mei=直樹
aut-affil-num=1
ORCID=

en-aut-name=IshiharaHisashi
en-aut-sei=Ishihara
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=2
ORCID=

en-aut-name=UnoMasako
en-aut-sei=Uno
en-aut-mei=Masako
kn-aut-name=宇野雅子
kn-aut-sei=宇野
kn-aut-mei=雅子
aut-affil-num=3
ORCID=

en-aut-name=AkagiYusuke
en-aut-sei=Akagi
en-aut-mei=Yusuke
kn-aut-name=赤木祐介
kn-aut-sei=赤木
kn-aut-mei=祐介
aut-affil-num=4
ORCID=

en-aut-name=KajiwaraSohei
en-aut-sei=Kajiwara
en-aut-mei=Sohei
kn-aut-name=梶原壮平
kn-aut-sei=梶原
kn-aut-mei=壮平
aut-affil-num=5
ORCID=

en-aut-name=FukumotoAki
en-aut-sei=Fukumoto
en-aut-mei=Aki
kn-aut-name=福本晶
kn-aut-sei=福本
kn-aut-mei=晶
aut-affil-num=6
ORCID=

en-aut-name=WakabayashiTokio
en-aut-sei=Wakabayashi
en-aut-mei=Tokio
kn-aut-name=若林時生
kn-aut-sei=若林
kn-aut-mei=時生
aut-affil-num=7
ORCID=

en-aut-name=TakeuchiAyako
en-aut-sei=Takeuchi
en-aut-mei=Ayako
kn-aut-name=竹内彩子
kn-aut-sei=竹内
kn-aut-mei=彩子
aut-affil-num=8
ORCID=

en-aut-name=AkisadaTakeshi
en-aut-sei=Akisada
en-aut-mei=Takeshi
kn-aut-name=秋定健
kn-aut-sei=秋定
kn-aut-mei=健
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital, Department of Head and Neck Surgery, Shikoku Cancer Center
kn-affil=岡山赤十字病院　耳鼻咽喉科, 国立病院機構四国がんセンター　頭頸科

affil-num=2
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科

affil-num=3
en-affil=Department of Otolaryngology, Kawasaki Medical School General Medical Center
kn-affil=川崎医科大学総合医療センター　耳鼻咽喉科

affil-num=4
en-affil=Department of Otolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター　耳鼻咽喉科

affil-num=5
en-affil=Department of Otolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター　耳鼻咽喉科

affil-num=6
en-affil=Department of Otolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター　耳鼻咽喉科

affil-num=7
en-affil=Department of Otolaryngology, Kawasaki Medical School Hospital
kn-affil=川崎医科大学附属病院　耳鼻咽喉科

affil-num=8
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科

affil-num=9
en-affil=Department of Otolaryngology, Kawasaki Medical School General Medical Center
kn-affil=川崎医科大学総合医療センター　耳鼻咽喉科
en-keyword=耳鼻咽喉科 (otolaryngology)
kn-keyword=耳鼻咽喉科 (otolaryngology)
en-keyword=救急体制 (emergency system)
kn-keyword=救急体制 (emergency system)
en-keyword=働き方改革 (work style reform)
kn-keyword=働き方改革 (work style reform)
en-keyword=専門医制度 (specialist system)
kn-keyword=専門医制度 (specialist system)
en-keyword=地域医療 (regional medical care)
kn-keyword=地域医療 (regional medical care)
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=1
article-no=
start-page=220
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191218
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Single-session esophagogastroduodenoscopy and endoscopic ultrasound using a forward-viewing radial scan ultrasonic endoscope
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Endoscopic ultrasound is useful for obtaining high-resolution images of pancreaticobiliary diseases, but is not readily available for physical checkups. In this study, we evaluated the safety and efficacy of single-session esophagogastroduodenoscopy and endoscopic ultrasound in the detection of upper-gastrointestinal and pancreaticobiliary diseases using a forward-viewing radial scan ultrasonic endoscope. <br/>
Methods: A total of 148 patients who were scheduled for upper-gastrointestinal screening using an endoscope were prospectively included. All patients were examined by EUS in combination with EGD using a forward-viewing radial scan ultrasonic endoscope. The primary endpoint was the safety of the procedures. The secondary endpoints were the prevalence of diseases, the basal imaging capability of EUS, the procedure time, total dose of propofol, and the correlation between background factors and the prevalence of pancreatic disease. The imaging capability at each region was scored as 0 (invisible) to 2 (sufficient visualization to evaluate the organs). <br/>
Results: Intraoperative hypotension occurred as an adverse event of intravenous anesthesia in one patient. There were 82 pancreaticobiliary findings and 165 upper-gastrointestinal findings (malignancy not included). Follicular lymphoma of the intra-abdominal lymph nodes was detected in one patient. The mean imaging scores of each section were 1.95 (pancreatic head and papilla), 2.0 (pancreatic body), 1.99 (pancreatic tail), and 1.89 (common bile duct and gallbladder). Age, history of diabetes mellitus, and smoking history were significantly associated with the prevalence of pancreatic diseases. <br/>
Conclusion: The simultaneous performance of EGD and EUS using a new ultrasonic endoscope is tolerable and safe for upper-gastrointestinal and pancreaticobiliary screening.
en-copyright=
kn-copyright=

en-aut-name=UchidaDaisuke
en-aut-sei=Uchida
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsumotoKazuyuki
en-aut-sei=Matsumoto
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiharaYuki
en-aut-sei=Ishihara
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsumiAkihiro
en-aut-sei=Matsumi
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SaragaiYosuke
en-aut-sei=Saragai
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakadaSaimon
en-aut-sei=Takada
en-aut-mei=Saimon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YabeShuntaro
en-aut-sei=Yabe
en-aut-mei=Shuntaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MuroShinichiro
en-aut-sei=Muro
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TomodaTakeshi
en-aut-sei=Tomoda
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HoriguchiShigeru
en-aut-sei=Horiguchi
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=
en-keyword=Endoscopic ultrasound
kn-keyword=Endoscopic ultrasound
en-keyword=Diagnostic screening program
kn-keyword=Diagnostic screening program
en-keyword=Pancreatic diseases
kn-keyword=Pancreatic diseases
en-keyword=Biliary tract diseases
kn-keyword=Biliary tract diseases
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=5817
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201949
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Helping-Like Behaviour in Mice Towards Conspecifics Constrained Inside Tubes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Prosocial behaviour, including helping behaviour, benefits others. Recently, helping-like behaviour has been observed in rats, but whether it is oriented towards rescue, social contact with others, or other goals remains unclear. Therefore, we investigated whether helping-like behaviour could be observed in mice similar to that in rats. Because mice are social animals widely used in neuroscience, the discovery of helping-like behaviour in mice would be valuable in clarifying the psychological and biological mechanisms underlying pro-sociability. We constrained mice inside tubes. Subject mice were allowed to move freely in cages with tubes containing constrained conspecifics. The subject mice released both cagemates and stranger mice but did not engage in opening empty tubes. Furthermore, the same behaviour was observed under aversive conditions and with anesthetised conspecifics. Interestingly, hungry mice opened the tubes containing food before engaging in tube-opening behaviour to free constrained conspecifics. Mice showed equal preferences for constrained and freely moving conspecifics. We demonstrated for the first time that mice show tube-opening behaviour. Furthermore, we partly clarified the purpose and motivation of this behaviour. An effective mouse model for helping-like behaviour would facilitate research on the mechanisms underlying prosocial behaviour.
en-copyright=
kn-copyright=

en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=5
article-no=
start-page=383
end-page=386
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Role of High Mobility Group Box-1 in Epileptogenesis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear. Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. In this review, we will mainly discuss the role of HMGB1 in epileptogenesis.
en-copyright=
kn-copyright=

en-aut-name=FuLi
en-aut-sei=Fu
en-aut-mei=Li
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishiboriMasahiro
en-aut-sei=Nishibori
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=HMGB1
kn-keyword=HMGB1
en-keyword=epileptogenesis
kn-keyword=epileptogenesis
en-keyword=inflammation
kn-keyword=inflammation
en-keyword=blood-brain barrier
kn-keyword=blood-brain barrier
END

start-ver=1.4
cd-journal=joma
no-vol=117
cd-vols=
no-issue=
article-no=
start-page=109038
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Behavioural effects of inhalation exposure to dizocilpine (MK-801) in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The complex pathophysiology of brain disorders and the difficulty of delivering therapeutic agents to the brain remain major obstacles in the research and development of new therapeutic methods for brain disorders. Therefore, delivering existing therapeutic agents to the central nervous system is expected to provide benefits in various diseases. In this study, we investigated whether inhaled central nervous system drugs reached the brain and affected mouse behaviour. Dizocilpine (MK-801), which increases locomotor activity in mice, was mainly used to study this hypothesis. First, we administered MK-801, an N-methyl-d-aspartate receptor antagonist, to mice via inhalation and examined whether it induced excessive activity similar to that observed after intraperitoneal administration. We also examined the time- and dose-dependency of drug induced changes in mouse behaviour after MK-801 inhalation. Next, we investigated whether inhalation of scopolamine, pentobarbital, and imipramine also affected mouse behaviour. Mice that inhaled MK-801 showed MK-801?induced hyperactivity similar to that observed following intraperitoneal administration. Furthermore, the extent of activity changed in a time- and dose-dependent manner after MK-801 inhalation. Inhalation of pentobarbital, scopolamine, and imipramine also changed mouse behaviour. These results demonstrate that inhalation of MK-801 exerts effects similar to those achieved with intraperitoneal and oral administration in mice. Thus, central nervous system agonists can reach the brain efficiently via inhalation. This finding may facilitate the development of improved therapies for brain disorders.
en-copyright=
kn-copyright=

en-aut-name=Ueno Hiroshi
en-aut-sei=Ueno
en-aut-mei= Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Suemitsu Shunsuke
en-aut-sei=Suemitsu
en-aut-mei= Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Murakami Shinji
en-aut-sei=Murakami
en-aut-mei= Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Kitamura Naoya
en-aut-sei=Kitamura
en-aut-mei= Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=Wani Kenta
en-aut-sei=Wani
en-aut-mei= Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Takahashi Yu
en-aut-sei=Takahashi
en-aut-mei= Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=Matsumoto Yosuke
en-aut-sei=Matsumoto
en-aut-mei= Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=Okamoto Motoi
en-aut-sei=Okamoto
en-aut-mei= Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=Ishihara Takeshi
en-aut-sei=Ishihara
en-aut-mei= Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare
kn-affil=

affil-num=2
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=7
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
en-keyword=Inhalation
kn-keyword=Inhalation
en-keyword=Dizocilpine
kn-keyword=Dizocilpine
en-keyword=MK-801
kn-keyword=MK-801
en-keyword=Mouse
kn-keyword=Mouse
en-keyword=Drug
kn-keyword=Drug
en-keyword=Schizophrenia
kn-keyword=Schizophrenia
END

start-ver=1.4
cd-journal=joma
no-vol=115
cd-vols=
no-issue=
article-no=
start-page=108879
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201907
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comprehensive behavioral study of the effects of vanillin inhalation in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Vanillin is widely used in food and cosmetics, among other substances, for its sweet smell. However, the neuropsychological effects of vanillin inhalation have not been elucidated. In this study, we investigated the effect of vanillin inhalation on mouse behavior. First, we investigated whether the aroma of vanillin was attractive or repulsive for mice. Thereafter, the mice inhaled vanillin for 20?min before each test in a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, cotton bud biting, and Porsolt forced swim tests). In these tests, the mice showed a neutral response to vanillin. Mice that inhaled vanillin had a suppressed pain response in the hot plate test. In addition, the grip strength of the forelimbs of mice that inhaled vanillin was decreased. No significant differences were found between the mice inhaling vanillin and control mice in the open field, Y-maze, tail suspension, forced swimming, and aggression tests. These results show that vanillin inhalation has anti-nociceptive effects, similar to other routes of administration. The results also show that vanillin inhalation does not cause significant behavioral effects.
en-copyright=
kn-copyright=

en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShimadaAtsumi
en-aut-sei=Shimada
en-aut-mei=Atsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakahashiYu
en-aut-sei=Takahashi
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=FujiwaraYuko
en-aut-sei=Fujiwara
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare
kn-affil=

affil-num=2
en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College
kn-affil=

affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=7
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=8
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Health and Sports Science, Kawasaki University of Medical Welfare
kn-affil=

affil-num=11
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
en-keyword=Anti-nociceptive
kn-keyword=Anti-nociceptive
en-keyword=Vanillin
kn-keyword=Vanillin
en-keyword=Essential oil
kn-keyword=Essential oil
en-keyword=Inhalation
kn-keyword=Inhalation
en-keyword=Analgesia
kn-keyword=Analgesia
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=
article-no=
start-page=1
end-page=17
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the developing central nervous system (CNS), extracellular matrix (ECM) molecules have regulating roles such as in brain development, neural-circuit maturation, and synaptic-function control. However, excluding the perineuronal net (PNN) area, the distribution, constituent elements, and expression level of granular ECM molecules (diffuse ECM) present in the mature CNS remain unclear. Diffuse ECM molecules in the CNS share the components of PNNs and are likely functional. As cortical functions are greatly region-dependent, we hypothesized that ECM molecules would differ in distribution, expression level, and components in a region- and layer-dependent manner. We examined the layer-specific expression of several chondroitin sulfate proteoglycans (aggrecan, neurocan, and brevican), tenascin-R, Wisteria floribunda agglutinin (WFA)-positive molecules, hyaluronic acid, and link protein in the somatosensory and piriform cortices of mature mice. Furthermore, we investigated expression changes in WFA-positive molecules due to aging. In the somatosensory cortex, PNN density was particularly high at layer 4 (L4), but not all diffuse ECM molecules were highly expressed at L4 compared to the other layers. There was almost no change in tenascin-R and hyaluronic acid in any somatosensory-cortex layer. Neurocan showed high expression in L1 of the somatosensory cortex. In the piriform cortex, many ECM molecules showed higher expression in L1 than in the other layers. However, hyaluronic acid showed high expression in deep layers. Here, we clarified that ECM molecules differ in constituent elements and expression in a region- and layer-dependent manner. Region-specific expression of ECM molecules is possibly related to functions such as region-specific plasticity and vulnerability.
en-copyright=
kn-copyright=

en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare
kn-affil=

affil-num=2
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
en-keyword=Extracellular matrix
kn-keyword=Extracellular matrix
en-keyword=Perineuronal nets
kn-keyword=Perineuronal nets
en-keyword=Piriform cortex
kn-keyword=Piriform cortex
en-keyword=Proteoglycans
kn-keyword=Proteoglycans
en-keyword=Somatosensory cortex
kn-keyword=Somatosensory cortex
en-keyword=Wisteria floribunda
kn-keyword=Wisteria floribunda
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=6
article-no=
start-page=e01945
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention.
en-copyright=
kn-copyright=

en-aut-name=UenoHiroshi
en-aut-sei=Ueno
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShimadaAtsumi
en-aut-sei=Shimada
en-aut-mei=Atsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuemitsuShunsuke
en-aut-sei=Suemitsu
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurakamiShinji
en-aut-sei=Murakami
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KitamuraNaoya
en-aut-sei=Kitamura
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=WaniKenta
en-aut-sei=Wani
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatsumotoYosuke
en-aut-sei=Matsumoto
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=FujiwaraYuko
en-aut-sei=Fujiwara
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IshiharaTakeshi
en-aut-sei=Ishihara
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare
kn-affil=

affil-num=2
en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College
kn-affil=

affil-num=3
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=

affil-num=7
en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Health and Sports Science, Kawasaki University of Medical Welfare
kn-affil=

affil-num=10
en-affil=Department of Psychiatry, Kawasaki Medical School
kn-affil=
en-keyword=Neuroscience
kn-keyword=Neuroscience
en-keyword=Physiology
kn-keyword=Physiology
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=
article-no=
start-page=18
end-page=21
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=What kind of environmental enrichment does mother mouse want?
kn-title=母マウスが望む環境エンリッチメントとは？ : 環境エンリッチメント選びを考える
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Environmental enrichment, whose material is commercially available, is today thought to improve animal welfare, for instance, control of stress. There were some reports that these report contribution of suppression of stress, which the mother mice suffer during nursing their pup. However, the effects on stress-suppression by introducing the enrichment materials is unknown. In this study, determined plasma and urinary corticosterone in the mother mice with or without the materials from their making to weaning.
en-copyright=
kn-copyright=

en-aut-name=IshiharaSumire
en-aut-sei=Ishihara
en-aut-mei=Sumire
kn-aut-name=石原すみれ
kn-aut-sei=石原
kn-aut-mei=すみれ
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Advanced Science Research Center, Okayama University
kn-affil=岡山大学 自然生命科学研究支援センター
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=3
article-no=
start-page=197
end-page=203
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Geriatric Trauma in Patients ≧85 Years Old in an Urban District of Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Japan's population has been skewing toward the elderly, but the outcomes of advanced elderly trauma are not clear. Here we compared the outcomes of very elderly trauma patients (≧85 years old) with those of 65- to 84-year-old trauma patients. We retrospectively reviewed the medical records of patients treated at Hyogo Emergency Medical Center from August 2010 to August 2016; 631 patients were entered in the study. We divided them into the younger geriatrics (YG group, 65-84 years old: n=534) and older geriatrics (OG group, ≧85 years old: n=97). The group’s patient characteristics, mortality, 1-year survival rate, and Barthel index were tabulated and compared. The patients’ mean age was 75.6±7.5 years. There was no significant difference in mortality between the YG and OG groups (9.6% vs. 15.1%, odds ratio [OR] 1.73; 95% confidence interval [CI] 0.93-3.23, p=0.083). The 1-year survival rate (94.4% vs. 77.8%, OR 0.19, 95% CI 0.07-0.51; p<0.01) and Barthel index (Median score; 100 (IQR: 85-100) vs. 80 (IQR: 15-95), OR 0.98, 95% CI 0.97 to 0.99, p<0.01) differed significantly between the groups. Our study did not find a significant difference in-hospital mortality between patients in the YG group and those in the OG group.
en-copyright=
kn-copyright=

en-aut-name=NishimuraTakeshi
en-aut-sei=Nishimura
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsuyamaShigenari
en-aut-sei=Matsuyama
en-aut-mei=Shigenari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiharaSatoshi
en-aut-sei=Ishihara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakayamaShinichi
en-aut-sei=Nakayama
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Hyogo Emergency Medical Center
kn-affil=

affil-num=4
en-affil=Hyogo Emergency Medical Center
kn-affil=

affil-num=5
en-affil=Department of Emergency and Critical Care Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Hyogo Emergency Medical Center
kn-affil=
en-keyword=aged
kn-keyword=aged
en-keyword=injury
kn-keyword=injury
en-keyword=mortality
kn-keyword=mortality
en-keyword=morbidity
kn-keyword=morbidity
en-keyword=trauma
kn-keyword=trauma
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=2
article-no=
start-page=155
end-page=160
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Clinical Characteristics of Severe Refractory Asthma Associated with the Effectiveness of Bronchial Thermoplasty
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We investigated the clinical characteristics of refractory asthma associated with the effectiveness of bronchial thermoplasty (BT). We retrospectively evaluated data from 10 patients who underwent BT between June 2016 and December 2017 at Okayama Medical Center. The following were measured before and 6 months post-BT: forced expiratory volume in 1.0 s (FEV1), fractional exhaled nitric oxide (FeNO), immunoglobulin E (IgE) level, blood eosinophil counts (Eosi), Asthma Quality of Life Questionnaire (AQLQ) score, and preventive medication use. At baseline, the mean post-bronchodilator FEV1 was 80.9% of the predicted value (range 45.6-115.7%). All patients were being treated with moderate- or high-dose inhaled corticosteroids and long-acting β2 agonists. The AQLQ improved from 4.26±1.67 at baseline to 5.59±0.94 at 6 months post-BT (p<0.05). The %FEV1, FeNO, IgE, and Eosi did not change significantly between baseline and 6 months post-BT. No severe complications were reported. BT was effective for non-allergic and non-eosinophilic in 3 patients, and allergic or eosinophilic in 4 patients. Their AQLQ improved by > 0.5 points post-BT. For both allergic and eosinophilic asthmatics following mepolizumab, BT was not useful. BT was effective for non-allergic and non-eosinophilic or allergic asthmatics, but insufficient for both allergic and eosinophilic following mepolizumab.
en-copyright=
kn-copyright=

en-aut-name=MinamiDaisuke
en-aut-sei=Minami
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KayataniHiroe
en-aut-sei=Kayatani
en-aut-mei=Hiroe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatoKen
en-aut-sei=Sato
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujiwaraKeiichi
en-aut-sei=Fujiwara
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShibayamaTakuo
en-aut-sei=Shibayama
en-aut-mei=Takuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YoneiToshiro
en-aut-sei=Yonei
en-aut-mei=Toshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SatoToshio
en-aut-sei=Sato
en-aut-mei=Toshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Respiratory Medicine, Okayama Medical Center
kn-affil=

affil-num=2
en-affil=Department of Respiratory Medicine, Okayama Medical Center
kn-affil=

affil-num=3
en-affil=Department of Respiratory Medicine, Okayama Medical Center
kn-affil=

affil-num=4
en-affil=Department of Respiratory Medicine, Okayama Medical Center
kn-affil=

affil-num=5
en-affil=Department of Respiratory Medicine, Okayama Medical Center
kn-affil=

affil-num=6
en-affil=Department of Respiratory Medicine, Okayama Medical Center
kn-affil=

affil-num=7
en-affil=Department of Respiratory Medicine, Okayama Medical Center
kn-affil=
en-keyword=bronchial thermoplasty
kn-keyword=bronchial thermoplasty
en-keyword=non-allergic asthma
kn-keyword=non-allergic asthma
en-keyword= non-eosinophilic asthma
kn-keyword= non-eosinophilic asthma
en-keyword=airway hyper-responsiveness
kn-keyword=airway hyper-responsiveness
en-keyword=patient selection
kn-keyword=patient selection
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=2
article-no=
start-page=109
end-page=115
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Clinicopathological Features and Outcomes of Endoscopic Submucosal Dissection for Superficial Cancer of the Pharynx
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. “Resect and watch” is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.
en-copyright=
kn-copyright=

en-aut-name=AbeMakoto
en-aut-sei=Abe
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Kawahara Yoshiro
en-aut-sei=Kawahara
en-aut-mei= Yoshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KanzakiHiromitsu
en-aut-sei=Kanzaki
en-aut-mei=Hiromitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawanoSeiji
en-aut-sei=Kawano
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TsumuraMunechika
en-aut-sei=Tsumura
en-aut-mei=Munechika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MakinoTakuma
en-aut-sei=Makino
en-aut-mei=Takuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NodaYohei
en-aut-sei=Noda
en-aut-mei=Yohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MarunakaHidenori
en-aut-sei=Marunaka
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NishizakiKazunori
en-aut-sei=Nishizaki
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Endoscopy, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil= Department of Pathology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of  Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of  Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of  Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of  Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of  Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology and Hepatology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=endoscopic submucosal dissection
kn-keyword=endoscopic submucosal dissection
en-keyword=superficial cancer
kn-keyword=superficial cancer
en-keyword=pharynx
kn-keyword=pharynx
en-keyword=endoscopic resection
kn-keyword=endoscopic resection
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoAtsushi
en-aut-sei=Matsumoto
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraTakehiro
en-aut-sei=Nakamura
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShinomiyaAya
en-aut-sei=Shinomiya
en-aut-mei=Aya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawakitaKenya
en-aut-sei=Kawakita
en-aut-mei=Kenya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawanishiMasahiko
en-aut-sei=Kawanishi
en-aut-mei=Masahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyakeKeisuke
en-aut-sei=Miyake
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KurodaYasuhiro
en-aut-sei=Kuroda
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KeepRichard F.
en-aut-sei=Keep
en-aut-mei=Richard F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TamiyaTakashi
en-aut-sei=Tamiya
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=2
en-affil=Department of Medical Technology, Kagawa Prefectural University of Health Sciences
kn-affil=

affil-num=3
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=4
en-affil=Emergency Medical Center, Kagawa University Hospital
kn-affil=

affil-num=5
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=6
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=7
en-affil=Emergency Medical Center, Kagawa University Hospital
kn-affil=

affil-num=8
en-affil=Department of Neurosurgery, University of Michigan
kn-affil=

affil-num=9
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=
en-keyword=biomarker
kn-keyword=biomarker
en-keyword=histidine-rich glycoprotein
kn-keyword=histidine-rich glycoprotein
en-keyword=predictor
kn-keyword=predictor
en-keyword=subarachnoid hemorrhage
kn-keyword=subarachnoid hemorrhage
en-keyword=vasospasm
kn-keyword=vasospasm
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=6
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Role of Kallikrein-Related Peptidases in Atopic Dermatitis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD.
en-copyright=
kn-copyright=

en-aut-name=MorizaneShin
en-aut-sei=Morizane
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=atopic dermatitis
kn-keyword=atopic dermatitis
en-keyword=kallikrein-related peptidases
kn-keyword=kallikrein-related peptidases
en-keyword=epidermal barrier dysfunction
kn-keyword=epidermal barrier dysfunction
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=1
article-no=
start-page=116
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170727
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A software architecture for Java programming learning assistant system
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= For advancements of Java programming educations, we have developed a Web-based Java Programming Learning System (JPLAS). JPLAS provides four problems with different levels, namely, element fill-inblank problem, value trace problem, statement fill-in-blank problem, and code writing problem, to cover students at different learning stages. Unfortunately, since JPLAS has been implemented by a number of students who studied in our group at different years, the code has become complex and redundant, which makes further extensions of JPLAS extremely hard. In this paper, we propose a software architecture for JPLAS to avoid redundancy. Based on the MVC model, our proposal uses Java for the model (M), HTML/CSS/JavaScript for the view (V), and JSP for the controller (C). Besides, adopting a design pattern, the marking functions of the four problems are implemented uniformly. For evaluations, after JPLAS is implemented with this architecture, the number of code files is compared with that of the previous implementation, and the number of additional files is examined for two new functions.
en-copyright=
kn-copyright=

en-aut-name=IshiharaNobuya
en-aut-sei=Ishihara
en-aut-mei=Nobuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FunabikiNobuo
en-aut-sei=Funabiki
en-aut-mei=Nobuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KuribayashiMinoru
en-aut-sei=Kuribayashi
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KaoWen-Chung
en-aut-sei=Kao
en-aut-mei=Wen-Chung
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Electrical Engineering, National Taiwan Normal University
kn-affil=
en-keyword=JPLAS
kn-keyword=JPLAS
en-keyword=Java programming education
kn-keyword=Java programming education
en-keyword=Web application
kn-keyword=Web application
en-keyword= MVC model
kn-keyword= MVC model
en-keyword=Software architecture
kn-keyword=Software architecture
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Javaプログラミング学習支援システムのソフトウェアアーキテクチャと2種類の新問題形式の提案
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaNobuya
en-aut-sei=Ishihara
en-aut-mei=Nobuya
kn-aut-name=石原信也
kn-aut-sei=石原
kn-aut-mei=信也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=リポポリサッカライド誘発性中耳炎における内耳および中耳におけるマクロファージ遊走阻止因子とCD74の発現
kn-title=Expression of macrophage migration inhibitory factor and CD74 in the inner ear and middle ear in lipopolysaccharide-induced otitis media
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaHisashi
en-aut-sei=Ishihara
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=5
article-no=
start-page=437
end-page=443
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Modification of Dentofacial Growth Associated with Goldenhar Syndrome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The rare developmental defect, Goldenhar syndrome is characterized by complex craniofacial and dentofacial anomalies. Here we describe the successful orthodontic treatment of a 5-year-old Japanese Goldenhar syndrome patient with mild facial asymmetry, right microtia, right-side hearing loss, and tongue-thrusting by a modification of dentofacial growth using a non-surgical orthopedic treatment approach. Improvement of the vertical discrepancies on the affected side and canted occlusal plane as well as mandibular deviation were achieved with a functional orthopaedic approach. Stable and acceptable occlusion were obtained over the 32-month post-retention period. A non-surgical orthodontic treatment approach offers satisfactory facial aesthetic outcomes in Goldenhar syndrome.

en-copyright=
kn-copyright=

en-aut-name=Ei Ei Hsu Hlaing
en-aut-sei=Ei Ei Hsu Hlaing
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HaraChikako
en-aut-sei=Hara
en-aut-mei=Chikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Goldenhar syndrome
kn-keyword=Goldenhar syndrome
en-keyword=orthodontic treatment
kn-keyword=orthodontic treatment
en-keyword=functional appliance
kn-keyword=functional appliance
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=4
article-no=
start-page=291
end-page=299
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201708
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Association between Skeletal Muscle Depletion and Sorafenib Treatment in Male Patients with Hepatocellular Carcinoma: A Retrospective Cohort Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The effect of skeletal muscle mass (SMM) on the outcomes of sorafenib treatment for hepatocellular carcinoma (HCC) has not been established. We measured the SMM in HCC patients treated with sorafenib, evaluated the patients’ survival, and evaluated the association between skeletal muscle depletion and sorafenib treatment. Of the 97 HCC patients treated with sorafenib at our institution in the period from July 2009 to February 2015, our study included 69 patients (51 males, 18 females) who had received sorafenib for ? 8 weeks and whose follow-up data were available. SMM was calculated from computed tomography images at the mid-L3 level (cm2) and normalized to height (m2) to yield the L3 skeletal muscle index (L3-SMI, cm2/m2). The median L3-SMI value was higher in the males (43 cm2/m2) compared to the females (36 cm2/m2). In the males only, the multivariate Cox regression identified an L3-SMI <43 cm2/m2 as independently associated with higher mortality compared to an L3-SMI ?43 cm2/m2 (hazard ratio 2.315, 95% confidence interval: 1.125-4.765, p=0.023). Skeletal muscle depletion is a factor predicting poor prognosis for male patients with advanced HCC treated with sorafenib.
en-copyright=
kn-copyright=

en-aut-name=NaganumaAtsushi
en-aut-sei=Naganuma
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HoshinoTakashi
en-aut-sei=Hoshino
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzukiYuhei
en-aut-sei=Suzuki
en-aut-mei=Yuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UeharaDaisuke
en-aut-sei=Uehara
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KudoTomohiro
en-aut-sei=Kudo
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshiharaHiroshi
en-aut-sei=Ishihara
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SatoKen
en-aut-sei=Sato
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KakizakiSatoru
en-aut-sei=Kakizaki
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamadaMasanobu
en-aut-sei=Yamada
en-aut-mei=Masanobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TakagiHitoshi
en-aut-sei=Takagi
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=7
en-affil=Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology, Kusunoki Hospital
kn-affil=
en-keyword=skeletal muscle depletion
kn-keyword=skeletal muscle depletion
en-keyword=hepatocellular carcinoma
kn-keyword=hepatocellular carcinoma
en-keyword=sorafenib
kn-keyword=sorafenib
en-keyword=L3 skeletal muscle index
kn-keyword=L3 skeletal muscle index
en-keyword=prognostic factor
kn-keyword=prognostic factor
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=項の末尾情報を利用した日本語意味役割付与システムの高性能化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaYasuhiro
en-aut-sei=Ishihara
en-aut-mei=Yasuhiro
kn-aut-name=石原靖弘
kn-aut-sei=石原
kn-aut-mei=靖弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=2
article-no=
start-page=119
end-page=130
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201604
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Diminished Gastric Resection Preserves Better Quality of Life in Patients with Early Gastric Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using the Postgastrectomy Syndrome Assessment Scale (PGSAS)-45, we compared the surgical outcomes and the quality of life (QOL) between patients undergoing limited gastrectomies and those undergoing conventional gastrectomies. In Oomoto Hospital between January 2004 and December 2013, a total of 124 patients who met the eligibility criteria were enrolled. Using the main outcome measures of PGSAS-45, we compared 4 types of limited gastrectomy procedures (1/2 distal gastrectomy [1/2DG] in 21 patients; pylorus-preserving gastrectomy [PPG] in 15 patients; segmental gastrectomy [SG] in 26 patients; and local resection [LR] in 13 patients) with conventional gastrectomy (total gastrectomy [TG] in 24 patients and 2/3 or more distal gastrectomy [WDG] in 25 patients). The TG group showed the worst QOL in almost all items of the main outcome measures. The 1/2DG, PPG, and SG groups showed better QOL than the WDG group in many of the main outcome measures, including the body weight ratio, total symptom score, ingested amount of food per meal, and the dissatisfaction for daily life subscale. The LR group showed a better intake of food than the 1/2DG, PPG, and SG groups. The body weight ratio of the LR group was better than that of the SG group. Diminished gastric resection preserved better QOL in patients with early gastric cancer.
en-copyright=
kn-copyright=

en-aut-name=IsozakiHiroshi
en-aut-sei=Isozaki
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoSasau
en-aut-sei=Matsumoto
en-aut-mei=Sasau
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MurakamiShigeki
en-aut-sei=Murakami
en-aut-mei=Shigeki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakamaTakehiro
en-aut-sei=Takama
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShoTatuo
en-aut-sei=Sho
en-aut-mei=Tatuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshiharaKiyohiro
en-aut-sei=Ishihara
en-aut-mei=Kiyohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakaiKunihiko
en-aut-sei=Sakai
en-aut-mei=Kunihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakedaMasanori
en-aut-sei=Takeda
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakadaKoji
en-aut-sei=Nakada
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Surgery, Oomoto Hospital

affil-num=2
en-affil=
kn-affil=Department of Surgery, Oomoto Hospital

affil-num=3
en-affil=
kn-affil=Department of Surgery, Oomoto Hospital

affil-num=4
en-affil=
kn-affil=Department of Surgery, Oomoto Hospital

affil-num=5
en-affil=
kn-affil=Department of Surgery, Oomoto Hospital

affil-num=6
en-affil=
kn-affil=Department of Surgery, Oomoto Hospital

affil-num=7
en-affil=
kn-affil=Department of Surgery, Oomoto Hospital

affil-num=8
en-affil=
kn-affil=Department of Surgery, Watanabe Hospital

affil-num=9
en-affil=
kn-affil=Department of Surgery, The Jikei University School of Medicine

affil-num=10
en-affil=
kn-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=limited gastrectomy
kn-keyword=limited gastrectomy
en-keyword=early gastric cancer
kn-keyword=early gastric cancer
en-keyword=function preserving gastrectomy
kn-keyword=function preserving gastrectomy
en-keyword=quality of life
kn-keyword=quality of life
en-keyword=postgastrectomy syndrome
kn-keyword=postgastrectomy syndrome
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=1
article-no=
start-page=57
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201602
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Orthodontic Treatment of a Patient with Bilateral Congenitally Missing Maxillary Canines: The Effects of First Premolar Substitution on the Functional Outcome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Permanent canines are thought to play a pivotal role in obtaining an ideal occlusion. Dentists occasionally encounter patients who lack canines and are therefore missing a key to harmonious guidance during functional mandibular excursions. This case report describes the substitution of maxillary first premolars for congenitally missing canines in the context of an orthodontic treatment plan. A boy, age 10 years and 11 months, with a chief complaint of crooked teeth was diagnosed with Class II division 2 malocclusion associated with a high mandibular plane angle and deep overbite. A stable occlusion with a satisfactory facial profile and functional excursions without interference were achieved after a comprehensive two-stage orthodontic treatment process. The resulting occlusion and satisfactory facial profile were maintained for 12 months. These results indicate that substituting the first premolars for the canines is an effective option in treating patients with missing canines while maintaining functional goals.
en-copyright=
kn-copyright=

en-aut-name=SumiyoshiKumi
en-aut-sei=Sumiyoshi
en-aut-mei=Kumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KomoriHiroki
en-aut-sei=Komori
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamashiroTakashi
en-aut-sei=Yamashiro
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=orthodontics
kn-keyword=orthodontics
en-keyword=missing canines
kn-keyword=missing canines
en-keyword=stomatognathic function
kn-keyword=stomatognathic function
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=139
end-page=148
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Organized and Sustainable Education Program for Drug Abuse Prevention by Yogo-teachers
kn-title=養護教諭が推進する組織的で継続可能な小学校の喫煙・飲酒・薬物乱用防止教育プログラムの開発と実践
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　学校における喫煙・飲酒・薬物乱用防止教育の充実には，問題行動が顕在化する中学校期だけでなく小学校期
における指導の推進が重要であり，系統的な指導計画を立て，指導者や時間の確保，教材作成などに組織的に取
組み，継続可能なプログラム開発を行う必要がある。そこで，地区内12 校の養護教諭が協働して，発達段階に応
じた系統的・組織的かつ継続可能な地区共通の指導計画を開発し，各校の教育課程・年間計画に位置付けた実践
研究を行った。その結果，指導計画の実施状況は，小学校11 校中，学級活動10 校，ミニ保健指導10 校，長期
休業前指導6 校，広報活動9 校となり，特別支援学校1 校では広報活動のみを行うことができた。小学校におけ
る喫煙・飲酒・薬物乱用防止教育の推進には，学校保健活動の中核的役割を担う養護教諭が専門性を活かし協働
して，系統的な指導計画を各校の教育課程に位置付け組織的で継続可能なプログラムとする取組が有効であった。
en-copyright=
kn-copyright=

en-aut-name=UenoYoshiko
en-aut-sei=Ueno
en-aut-mei=Yoshiko
kn-aut-name=上野芳子
kn-aut-sei=上野
kn-aut-mei=芳子
aut-affil-num=1
ORCID=

en-aut-name=NishimuraTakae
en-aut-sei=Nishimura
en-aut-mei=Takae
kn-aut-name=西村孝江
kn-aut-sei=西村
kn-aut-mei=孝江
aut-affil-num=2
ORCID=

en-aut-name=HosakaSayuri
en-aut-sei=Hosaka
en-aut-mei=Sayuri
kn-aut-name=保坂小百合
kn-aut-sei=保坂
kn-aut-mei=小百合
aut-affil-num=3
ORCID=

en-aut-name=YamamotoMasae
en-aut-sei=Yamamoto
en-aut-mei=Masae
kn-aut-name=山本雅恵
kn-aut-sei=山本
kn-aut-mei=雅恵
aut-affil-num=4
ORCID=

en-aut-name=AkasakaRie
en-aut-sei=Akasaka
en-aut-mei=Rie
kn-aut-name=赤坂理恵
kn-aut-sei=赤坂
kn-aut-mei=理恵
aut-affil-num=5
ORCID=

en-aut-name=ArimatuAyumi
en-aut-sei=Arimatu
en-aut-mei=Ayumi
kn-aut-name=有松亜由美
kn-aut-sei=有松
kn-aut-mei=亜由美
aut-affil-num=6
ORCID=

en-aut-name=FujiiHarue
en-aut-sei=Fujii
en-aut-mei=Harue
kn-aut-name=藤井治江
kn-aut-sei=藤井
kn-aut-mei=治江
aut-affil-num=7
ORCID=

en-aut-name=YuguchiMakoto
en-aut-sei=Yuguchi
en-aut-mei=Makoto
kn-aut-name=湯口真琴
kn-aut-sei=湯口
kn-aut-mei=真琴
aut-affil-num=8
ORCID=

en-aut-name=TorigoeKanako
en-aut-sei=Torigoe
en-aut-mei=Kanako
kn-aut-name=鳥越加奈子
kn-aut-sei=鳥越
kn-aut-mei=加奈子
aut-affil-num=9
ORCID=

en-aut-name=OonishiMarika
en-aut-sei=Oonishi
en-aut-mei=Marika
kn-aut-name=大西真莉香
kn-aut-sei=大西
kn-aut-mei=真莉香
aut-affil-num=10
ORCID=

en-aut-name=NanbaYumiko
en-aut-sei=Nanba
en-aut-mei=Yumiko
kn-aut-name=難波有美子
kn-aut-sei=難波
kn-aut-mei=有美子
aut-affil-num=11
ORCID=

en-aut-name=MoriAyako
en-aut-sei=Mori
en-aut-mei=Ayako
kn-aut-name=森文子
kn-aut-sei=森
kn-aut-mei=文子
aut-affil-num=12
ORCID=

en-aut-name=WashidaHiroe
en-aut-sei=Washida
en-aut-mei=Hiroe
kn-aut-name=鷲田洋恵
kn-aut-sei=鷲田
kn-aut-mei=洋恵
aut-affil-num=13
ORCID=

en-aut-name=NishimotoKeiko
en-aut-sei=Nishimoto
en-aut-mei=Keiko
kn-aut-name=西本圭子
kn-aut-sei=西本
kn-aut-mei=圭子
aut-affil-num=14
ORCID=

en-aut-name=HinoYuko
en-aut-sei=Hino
en-aut-mei=Yuko
kn-aut-name=日野裕子
kn-aut-sei=日野
kn-aut-mei=裕子
aut-affil-num=15
ORCID=

en-aut-name=MatumotoTomoko
en-aut-sei=Matumoto
en-aut-mei=Tomoko
kn-aut-name=松本智子
kn-aut-sei=松本
kn-aut-mei=智子
aut-affil-num=16
ORCID=

en-aut-name=IshiharaTomoko
en-aut-sei=Ishihara
en-aut-mei=Tomoko
kn-aut-name=石原智子
kn-aut-sei=石原
kn-aut-mei=智子
aut-affil-num=17
ORCID=

en-aut-name=TodoMariko
en-aut-sei=Todo
en-aut-mei=Mariko
kn-aut-name=藤堂真莉子
kn-aut-sei=藤堂
kn-aut-mei=真莉子
aut-affil-num=18
ORCID=

en-aut-name=YamamotoKumiko
en-aut-sei=Yamamoto
en-aut-mei=Kumiko
kn-aut-name=山本久美子
kn-aut-sei=山本
kn-aut-mei=久美子
aut-affil-num=19
ORCID=

en-aut-name=SadamoriNatuki
en-aut-sei=Sadamori
en-aut-mei=Natuki
kn-aut-name=定森奈月
kn-aut-sei=定森
kn-aut-mei=奈月
aut-affil-num=20
ORCID=

en-aut-name=YamagamiNao
en-aut-sei=Yamagami
en-aut-mei=Nao
kn-aut-name=山上奈緒
kn-aut-sei=山上
kn-aut-mei=奈緒
aut-affil-num=21
ORCID=

en-aut-name=OkamotoKanako
en-aut-sei=Okamoto
en-aut-mei=Kanako
kn-aut-name=岡本佳菜子
kn-aut-sei=岡本
kn-aut-mei=佳菜子
aut-affil-num=22
ORCID=

en-aut-name=MatsuoHiromi
en-aut-sei=Matsuo
en-aut-mei=Hiromi
kn-aut-name=松尾裕未
kn-aut-sei=松尾
kn-aut-mei=裕未
aut-affil-num=23
ORCID=

en-aut-name=KobayashiShizuka
en-aut-sei=Kobayashi
en-aut-mei=Shizuka
kn-aut-name=小林静香
kn-aut-sei=小林
kn-aut-mei=静香
aut-affil-num=24
ORCID=

en-aut-name=HayashiKanako
en-aut-sei=Hayashi
en-aut-mei=Kanako
kn-aut-name=林加奈子
kn-aut-sei=林
kn-aut-mei=加奈子
aut-affil-num=25
ORCID=

en-aut-name=MizushimaNozomi
en-aut-sei=Mizushima
en-aut-mei=Nozomi
kn-aut-name=水島希望
kn-aut-sei=水島
kn-aut-mei=希望
aut-affil-num=26
ORCID=

en-aut-name=SekiyamaKen-ichi
en-aut-sei=Sekiyama
en-aut-mei=Ken-ichi
kn-aut-name=関山賢一
kn-aut-sei=関山
kn-aut-mei=賢一
aut-affil-num=27
ORCID=

en-aut-name=FukushimaTakashi
en-aut-sei=Fukushima
en-aut-mei=Takashi
kn-aut-name=福嶋隆
kn-aut-sei=福嶋
kn-aut-mei=隆
aut-affil-num=28
ORCID=

en-aut-name=KamimuraHiroko
en-aut-sei=Kamimura
en-aut-mei=Hiroko
kn-aut-name=上村弘子
kn-aut-sei=上村
kn-aut-mei=弘子
aut-affil-num=29
ORCID=

en-aut-name=TakahashiKayo
en-aut-sei=Takahashi
en-aut-mei=Kayo
kn-aut-name=高橋香代
kn-aut-sei=高橋
kn-aut-mei=香代
aut-affil-num=30
ORCID=

affil-num=1
en-affil=
kn-affil=倉敷市立西阿知小学校

affil-num=2
en-affil=
kn-affil=倉敷市立粒江小学校

affil-num=3
en-affil=
kn-affil=倉敷市立連島北小学校

affil-num=4
en-affil=
kn-affil=倉敷市立老松小学校

affil-num=5
en-affil=
kn-affil=倉敷市立老松小学校

affil-num=6
en-affil=
kn-affil=倉敷市立老松小学校

affil-num=7
en-affil=
kn-affil=倉敷市立大高小学校

affil-num=8
en-affil=
kn-affil=倉敷市立大高小学校

affil-num=9
en-affil=
kn-affil=倉敷市立大高小学校

affil-num=10
en-affil=
kn-affil=倉敷市立中洲小学校

affil-num=11
en-affil=
kn-affil=倉敷市立中洲小学校

affil-num=12
en-affil=
kn-affil=倉敷市立天城小学校

affil-num=13
en-affil=
kn-affil=倉敷市立西阿知小学校

affil-num=14
en-affil=
kn-affil=倉敷市立西阿知小学校

affil-num=15
en-affil=
kn-affil=倉敷市立西阿知小学校

affil-num=16
en-affil=
kn-affil=倉敷市立倉敷南小学校

affil-num=17
en-affil=
kn-affil=倉敷市立中島小学校

affil-num=18
en-affil=
kn-affil=倉敷市立中島小学校

affil-num=19
en-affil=
kn-affil=倉敷市立葦高小学校

affil-num=20
en-affil=
kn-affil=倉敷市立葦高小学校

affil-num=21
en-affil=
kn-affil=倉敷市立旭丘小学校

affil-num=22
en-affil=
kn-affil=倉敷市立旭丘小学校

affil-num=23
en-affil=
kn-affil=倉敷市立倉敷支援学校

affil-num=24
en-affil=
kn-affil=倉敷市立倉敷支援学校

affil-num=25
en-affil=
kn-affil=倉敷市立倉敷支援学校

affil-num=26
en-affil=
kn-affil=倉敷市立倉敷支援学校

affil-num=27
en-affil=
kn-affil=倉敷市立葦高小学校

affil-num=28
en-affil=
kn-affil=倉敷市立老松小学校

affil-num=29
en-affil=
kn-affil=岡山大学大学院教育学研究科

affil-num=30
en-affil=
kn-affil=くらしき作陽大学こども教育学部
en-keyword=小学校
kn-keyword=小学校
en-keyword=健康教育
kn-keyword=健康教育
en-keyword=喫煙・飲酒・薬物乱用防止教育
kn-keyword=喫煙・飲酒・薬物乱用防止教育
en-keyword=養護教諭
kn-keyword=養護教諭
en-keyword=中核的役割
kn-keyword=中核的役割
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=3
article-no=
start-page=224
end-page=231
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comprehensive investigation of areae gastricae pattern in gastric corpus using magnifying narrow band imaging endoscopy in patients with chronic atrophic fundic gastritis.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background:? Barium radiographic studies have suggested the importance of evaluating areae gastricae pattern for the diagnosis of gastritis. Significance of endoscopic appearance of areae gastricae in the diagnosis of chronic atrophic fundic gastritis (CAFG) was investigated by image-enhanced endoscopy.

Materials and Methods:? Endoscopic images of the corpus lesser curvature were studied in 50 patients with CAFG. Extent of CAFG was evaluated with autofluorescence imaging endoscopy. The areae gastricae pattern was evaluated with 0.2% indigo carmine chromoendoscopy. Micro-mucosal structure was examined with magnifying chromoendoscopy and narrow band imaging.

Results:? In patients with small extent of CAFG, polygonal areae gastricae separated by a narrow intervening part of areae gastricae was observed, whereas in patients with wide extent of CAFG, the size of the areae gastricae decreased and the width of the intervening part of areae gastricae increased (p < 0.001). Most areae gastricae showed a foveola-type micro-mucosal structure (82.7%), while intervening part of areae gastricae had a groove-type structure (98.0%, p < 0.001). Groove-type mucosa had a higher grade of atrophy (p < 0.001) and intestinal metaplasia (p < 0.001) compared with foveola type.

Conclusions:? As extent of CAFG widened, multifocal groove-type mucosa that had high-grade atrophy and intestinal metaplasia developed among areae gastricae and increased along the intervening part of areae gastricae. Our observations facilitate our understanding of the development and progression of CAFG.
en-copyright=
kn-copyright=

en-aut-name=KanzakiHiromitsu
en-aut-sei=Kanzaki
en-aut-mei=Hiromitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UedoNoriya
en-aut-sei=Uedo
en-aut-mei=Noriya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshiharaRyu
en-aut-sei=Ishihara
en-aut-mei=Ryu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NagaiKengo
en-aut-sei=Nagai
en-aut-mei=Kengo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsuiFumi
en-aut-sei=Matsui
en-aut-mei=Fumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OhtaTakashi
en-aut-sei=Ohta
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HanafusaMasao
en-aut-sei=Hanafusa
en-aut-mei=Masao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HanaokaNoboru
en-aut-sei=Hanaoka
en-aut-mei=Noboru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TakeuchiYoji
en-aut-sei=Takeuchi
en-aut-mei=Yoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HigashinoKoji
en-aut-sei=Higashino
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=IishiHiroyasu
en-aut-sei=Iishi
en-aut-mei=Hiroyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TomitaYasuhiko
en-aut-sei=Tomita
en-aut-mei=Yasuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TatsutaMasaharu
en-aut-sei=Tatsuta
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=YamamotoKazuhide
en-aut-sei=Yamamoto
en-aut-mei=Kazuhide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=3
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=4
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=5
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=6
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=7
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=8
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=9
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=10
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=11
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=12
en-affil=
kn-affil=Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=13
en-affil=
kn-affil=Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases

affil-num=14
en-affil=
kn-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
en-keyword=Chronic atrophc fundic gastritis
kn-keyword=Chronic atrophc fundic gastritis
en-keyword=image enhanced endoscopy
kn-keyword=image enhanced endoscopy
en-keyword=areae gastricae
kn-keyword=areae gastricae
en-keyword=magnified endoscopy
kn-keyword=magnified endoscopy
en-keyword=narrow band imaging
kn-keyword=narrow band imaging
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140102
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cross-cultural validity of a dietary questionnaire for studies of dental caries risk in Japanese
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Diet is a major modifiable contributing factor in the etiology of dental caries. The purpose of this paper is to examine the reliability and cross-cultural validity of the Japanese version of the Food Frequency Questionnaire to assess dietary intake in relation to dental caries risk in Japanese. 

Methods: The 38-item Food Frequency Questionnaire, in which Japanese food items were added to increase content validity, was translated into Japanese, and administered to two samples. The first sample comprised 355 pregnant women with mean age of 29.2 +/- 4.2 years for the internal consistency and criterion validity analyses. Factor analysis (principal components with Varimax rotation) was used to determine dimensionality. The dietary cariogenicity score was calculated from the Food Frequency Questionnaire and used for the analyses. Salivary mutans streptococci level was used as a semi-quantitative assessment of dental caries risk and measured by Dentocult SM. Dentocult SM scores were compared with the dietary cariogenicity score computed from the Food Frequency Questionnaire to examine criterion validity, and assessed by Spearman's correlation coefficient (r(s)) and Kruskal-Wallis test. Test-retest reliability of the Food Frequency Questionnaire was assessed with a second sample of 25 adults with mean age of 34.0 +/- 3.0 years by using the intraclass correlation coefficient analysis. 

Results: The Japanese language version of the Food Frequency Questionnaire showed high test-retest reliability (ICC = 0.70) and good criterion validity assessed by relationship with salivary mutans streptococci levels (r(s) = 0.22; p < 0.001). Factor analysis revealed four subscales that construct the questionnaire (solid sugars, solid and starchy sugars, liquid and semisolid sugars, sticky and slowly dissolving sugars). Internal consistency were low to acceptable (Cronbach's alpha = 0.67 for the total scale, 0.46-0.61 for each subscale). Mean dietary cariogenicity scores were 50.8 +/- 19.5 in the first sample, 47.4 +/- 14.1, and 40.6 +/- 11.3 for the first and second administrations in the second sample. The distribution of Dentocult SM score was 6.8% (score = 0), 34.4% (score = 1), 39.4% (score = 2), and 19.4% (score = 3). Participants with higher scores were more likely to have higher dietary cariogenicity scores (p < 0.001; Kruskal-Wallis test). 

Conclusions: These results provide the preliminary evidence for the reliability and validity of the Japanese language Food Frequency Questionnaire.
en-copyright=
kn-copyright=

en-aut-name=Shinga-IshiharaChikako
en-aut-sei=Shinga-Ishihara
en-aut-mei=Chikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakaiYukie
en-aut-sei=Nakai
en-aut-mei=Yukie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MilgromPeter
en-aut-sei=Milgrom
en-aut-mei=Peter
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurakamiKaori
en-aut-sei=Murakami
en-aut-mei=Kaori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=Matsumoto-NakanoMichiyo
en-aut-sei=Matsumoto-Nakano
en-aut-mei=Michiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pediat Dent

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pediat Dent

affil-num=3
en-affil=
kn-affil=Univ Washington, Dept Oral Hlth Sci

affil-num=4
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pediat Dent

affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Pediat Dent
en-keyword=Food frequency questionnaire
kn-keyword=Food frequency questionnaire
en-keyword=Cariogenic food
kn-keyword=Cariogenic food
en-keyword=Diet
kn-keyword=Diet
en-keyword=Reliability
kn-keyword=Reliability
en-keyword=Validity
kn-keyword=Validity
en-keyword=Mutans streptococci
kn-keyword=Mutans streptococci
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20131201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case-control study in Japanese women
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were to validate the association between reported SNPs and breast cancer risk in the Japanese population and to evaluate the effects of SNP genotypes and lifestyle factors on breast cancer risk. 

Methods: A case-control study in 472 patients and 464 controls was conducted from December 2010 to November 2011. Lifestyle was examined using a self-administered questionnaire. We analyzed 16 breast cancer-associated SNPs based on previous GWAS or candidate-gene association studies. Age or multivariate-adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were estimated from logistic regression analyses. 

Results: High BMI and current or former smoking were significantly associated with an increased breast cancer risk, while intake of meat, mushrooms, yellow and green vegetables, coffee, and green tea, current leisure-time exercise, and education were significantly associated with a decreased risk. Three SNPs were significantly associated with a breast cancer risk in multivariate analysis: rs2046210 (per allele OR = 1.37 [95% CI: 1.11-1.70]), rs3757318 (OR = 1.33[1.05-1.69]), and rs3803662 (OR = 1.28 [1.07-1.55]). In 2046210 risk allele carriers, leisure-time exercise was associated with a significantly decreased risk for breast cancer, whereas current smoking and high BMI were associated with a significantly decreased risk in non-risk allele carriers. 

Conclusion: In Japanese women, rs2046210 and 3757318 located near the ESR1 gene are associated with a risk of breast cancer, as in other Asian women. However, our findings suggest that exercise can decrease this risk in allele carriers.
en-copyright=
kn-copyright=

en-aut-name=MizooTaeko
en-aut-sei=Mizoo
en-aut-mei=Taeko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TairaNaruto
en-aut-sei=Taira
en-aut-mei=Naruto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishiyamaKeiko
en-aut-sei=Nishiyama
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NogamiTomohiro
en-aut-sei=Nogami
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IwamotoTakayuki
en-aut-sei=Iwamoto
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MotokiTakayuki
en-aut-sei=Motoki
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShienTadahiko
en-aut-sei=Shien
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=DoiharaHiroyoshi
en-aut-sei=Doihara
en-aut-mei=Hiroyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IshiharaSetsuko
en-aut-sei=Ishihara
en-aut-mei=Setsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KawaiHiroshi
en-aut-sei=Kawai
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KawasakiKensuke
en-aut-sei=Kawasaki
en-aut-mei=Kensuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IshibeYouichi
en-aut-sei=Ishibe
en-aut-mei=Youichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=OgasawaraYutaka
en-aut-sei=Ogasawara
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KomoikeYoshifumi
en-aut-sei=Komoike
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=MiyoshiShinichiro
en-aut-sei=Miyoshi
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg

affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg

affil-num=4
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg

affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg

affil-num=6
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg

affil-num=7
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg

affil-num=8
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg

affil-num=9
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg

affil-num=10
en-affil=
kn-affil=Okayama Saiseikai Gen Hosp, Dept Radiol

affil-num=11
en-affil=
kn-affil=Okayama Rousai Hosp, Dept Breast Surg

affil-num=12
en-affil=
kn-affil=Kagawa Prefectural Canc Detect Ctr, Dept Breast Surg

affil-num=13
en-affil=
kn-affil=Mizushima Kyodo Hosp, Dept Breast Surg

affil-num=14
en-affil=
kn-affil=Dept Breast & Endocrinol Surg

affil-num=15
en-affil=
kn-affil=Kinki Univ Hosp, Fac Med

affil-num=16
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gen Thorac Surg & Breast & Endocrinol Surg
en-keyword=Japanese women
kn-keyword=Japanese women
en-keyword=Asian
kn-keyword=Asian
en-keyword=Breast cancer
kn-keyword=Breast cancer
en-keyword=Lifestyle
kn-keyword=Lifestyle
en-keyword=Leisure-time exercise
kn-keyword=Leisure-time exercise
en-keyword=Parity
kn-keyword=Parity
en-keyword=Single nucleotide polymorphisms
kn-keyword=Single nucleotide polymorphisms
en-keyword=rs2046210
kn-keyword=rs2046210
en-keyword=rs3757318
kn-keyword=rs3757318
en-keyword=ESR1
kn-keyword=ESR1
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=日本人における齲蝕発症リスクに関する食事調査票の妥当性の検証
kn-title=Cross-cultural Validity of a Dietary Questionnaire for Studies of Dental Caries Risk in Japanese
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ShingaChikako
en-aut-sei=Shinga
en-aut-mei=Chikako
kn-aut-name=進賀知加子
kn-aut-sei=進賀
kn-aut-mei=知加子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=2
article-no=
start-page=99
end-page=102
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2013 Incentive Award of the Okayama Medical Association in Neuroscience (2013 Niimi Prize)
kn-title=平成25年度岡山医学会賞 脳神経研究奨励賞（新見賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OshimaEtsuko
en-aut-sei=Oshima
en-aut-mei=Etsuko
kn-aut-name=大島悦子
kn-aut-sei=大島
kn-aut-mei=悦子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院　精神科神経科
END

start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=1
article-no=
start-page=35
end-page=42
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=201103
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Expression and functional analysis of the barley Nud gene using transgenic rice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Most cereal crops have hulless grains (naked caryopses) with a free-threshing trait, whereas the majority of barley cultivars show hulled (covered) caryopses. The naked caryopsis in barley is genetically controlled by a single locus, nod. The Nud gene (the covered caryopsis allele) encodes an ethylene response factor (ERF) family transcription factor that regulates a lipid biosynthetic pathway. For functional analysis of the barley Nud gene, we produced transgenic rice expressing Nod in the developing caryopses. All transgenic lines had caryopses that were easily dehulled at maturity, indicating that the naked caryopsis phenotype remained in spite of expression of the Nod transgene. Histochemical and lipid analyses of the transgenic rice caryopses did not show increased lipid accumulation on the surface of developing caryopses, suggesting that the Nud-mediated lipid pathway may not function in rice caryopses. The predicted rice ortholog of Nod, Os06ERF was expressed specifically in the developing caryopses. However, expression of Os06ERF ceased at an earlier developmental stage than that of the native Nod gene in barley caryopses, which was also the case for expression of the Nod transgene. This raises the alternative hypothesis that the timing of Nod expression may be critical for activating the pathway for hull-caryopsis adhesion.
en-copyright=
kn-copyright=

en-aut-name=KakedaKatsuyuki
en-aut-sei=Kakeda
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaNorimitsu
en-aut-sei=Ishihara
en-aut-mei=Norimitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IzumiYohei
en-aut-sei=Izumi
en-aut-mei=Yohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SatoKazuhiro
en-aut-sei=Sato
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TaketaShin
en-aut-sei=Taketa
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Mie Univ, Grad Sch Bioresources
kn-affil=

affil-num=2
en-affil=Mie Univ, Grad Sch Bioresources
kn-affil=

affil-num=3
en-affil=Okayama Univ, Inst Plant Sci & Resources
kn-affil=

affil-num=4
en-affil=Okayama Univ, Inst Plant Sci & Resources
kn-affil=

affil-num=5
en-affil=Okayama Univ, Inst Plant Sci & Resources
kn-affil=
en-keyword=Nud gene
kn-keyword=Nud gene
en-keyword=transformation
kn-keyword=transformation
en-keyword=covered/naked caryopsis
kn-keyword=covered/naked caryopsis
en-keyword=lipid biosynthesis
kn-keyword=lipid biosynthesis
en-keyword=ERF/AP2
kn-keyword=ERF/AP2
en-keyword=grass
kn-keyword=grass
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=日本人女性における乳腺濃度とライフスタイルとの関連性
kn-title=Association between Mammographic Breast Density and Lifestyle in Japanese Women
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaSetsuko
en-aut-sei=Ishihara
en-aut-mei=Setsuko
kn-aut-name=石原節子
kn-aut-sei=石原
kn-aut-mei=節子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=67
cd-vols=
no-issue=3
article-no=
start-page=145
end-page=151
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=201306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Association between Mammographic Breast Density and Lifestyle in Japanese Women
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A high mammographic breast density is considered to be a risk factor for breast cancer. However, only a small number of studies on the association between breast density and lifestyle have been performed. A cross-sectional study was performed using a survey with 29 questions on life history and lifestyle. The breast density on mammography was classified into 4 categories following the BI-RADS criteria. The subjects were 522 women with no medical history of breast cancer. The mean age was 53.3 years old. On multivariate analysis, only BMI was a significant factor determining breast density in premenopausal women (parameter estimate, −0.403;p value, 0.0005), and the density decreased as BMI rose. In postmenopausal women, BMI (parameter estimate, −0.196;p value, 0.0143) and number of deliveries (parameter estimate, −0.388;p value, 0.0186) were significant factors determining breast density;breast density decreased as BMI and number of deliveries increased. Only BMI and number of deliveries were identified as factors significantly influencing breast density. BMI was inversely correlated with breast density before and after menopause, whereas the influence of number of deliveries on breast density was significant only in postmenopausal women in their 50 and 60s.
en-copyright=
kn-copyright=

en-aut-name=IshiharaSetsuko
en-aut-sei=Ishihara
en-aut-mei=Setsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TairaNaruto
en-aut-sei=Taira
en-aut-mei=Naruto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KawasakiKensuke
en-aut-sei=Kawasaki
en-aut-mei=Kensuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshibeYouichi
en-aut-sei=Ishibe
en-aut-mei=Youichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MizooTaeko
en-aut-sei=Mizoo
en-aut-mei=Taeko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NishiyamaKeiko
en-aut-sei=Nishiyama
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=IwamotoTakayuki
en-aut-sei=Iwamoto
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NogamiTomohiro
en-aut-sei=Nogami
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MotokiTakayuki
en-aut-sei=Motoki
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ShienTadahiko
en-aut-sei=Shien
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MatsuokaJunji
en-aut-sei=Matsuoka
en-aut-mei=Junji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=DoiharaHiroyoshi
en-aut-sei=Doihara
en-aut-mei=Hiroyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KomoikeYoshifumi
en-aut-sei=Komoike
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SatoShuhei
en-aut-sei=Sato
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KanazawaSusumu
en-aut-sei=Kanazawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Radiology, Okayama Saiseikai General Hospital

affil-num=2
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=3
en-affil=
kn-affil=Department of Surgery, Kagawa Prefectural Cancer Detection Center

affil-num=4
en-affil=
kn-affil=Department of Surgery, Mizushima Kyodo Hospital

affil-num=5
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=6
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=7
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=8
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=9
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=10
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=11
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=12
en-affil=
kn-affil=Department of Breast and Endocrine Surgery, Okayama University Hospital

affil-num=13
en-affil=
kn-affil=Department of Surgery, Kinki University Hospital

affil-num=14
en-affil=
kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=15
en-affil=
kn-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=mammographic breast density
kn-keyword=mammographic breast density
en-keyword=life style
kn-keyword=life style
en-keyword=body mass index
kn-keyword=body mass index
END

start-ver=1.4
cd-journal=joma
no-vol=2012-NL-207
cd-vols=
no-issue=15
article-no=
start-page=1
end-page=7
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120719
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Discussion of Possible Semantic Description for Documents Based on Analysis of Predicate-Argument Structure
kn-title=述語の分析に基づく文書解析の考察
en-subtitle=
kn-subtitle=
en-abstract=The results of our previous work of construction of Japanese verb thesaurus revealed that a verb meaning often contains not only action or change-of-state meaning, i.e., objective meaning, but subjective meanings. To describe verb meaning, lexical conceptual structure was applied, but it does not have a place of subjective and modal meaning; then they are described using natural language embedded in an extended LCS-based schema. Modal logic gives us a description framework, but verb meanings have more complex meaning, such as event attributes, progress and possibility. In the manuscript we summarize the wide variety of verb and adjective verb meaning from the view of change-of-state and subjective meaning, then discuss a description framework of them according to modal logic study.
kn-abstract=動詞間で共通する意味属性を考慮して,シソーラス上に整理した動詞項構造シソーラスを提案し,形容動詞まで拡張して分析を進めてきた.動詞項構造シソーラスの背景には語彙概念構造という状態変化を主に記述する形式を拡張してきたが,「必要だ」や「必ず?する」といった主観的な内容を記述する場所が無く,意味記述の中に自然言語で埋めることになっている.本稿では述語の分析から必要となる意味構造の要件を明らかにする.その中でも可能世界意味論に関係している点を事例をもとに明確化し,文書解析のための意味構造について考察する.さらに,人工知能で議論されてきた様相論理,動的命題,設計学,オントロジー工学との関係について概観する.
en-copyright=
kn-copyright=

en-aut-name=TakeuchiKoichi
en-aut-sei=Takeuchi
en-aut-mei=Koichi
kn-aut-name=竹内孔一
kn-aut-sei=竹内
kn-aut-mei=孔一
aut-affil-num=1
ORCID=

en-aut-name=TakeuchiNao
en-aut-sei=Takeuchi
en-aut-mei=Nao
kn-aut-name=竹内奈央
kn-aut-sei=竹内
kn-aut-mei=奈央
aut-affil-num=2
ORCID=

en-aut-name=IshiharaYasuhiro
en-aut-sei=Ishihara
en-aut-mei=Yasuhiro
kn-aut-name=石原靖弘
kn-aut-sei=石原
kn-aut-mei=靖弘
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=岡山大学大学院
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=115
end-page=117
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Therapy for hyperthermia-induced seizures in Scn1a mutant rats
kn-title=Scn1a遺伝子変異ラットを用いた抗てんかん薬の熱性けいれん抑制効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HayashiKeiichiro
en-aut-sei=Hayashi
en-aut-mei=Keiichiro
kn-aut-name=林桂一郎
kn-aut-sei=林
kn-aut-mei=桂一郎
aut-affil-num=1
ORCID=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=大守伊織
kn-aut-sei=大守
kn-aut-mei=伊織
aut-affil-num=2
ORCID=

en-aut-name=MatsuiHideki
en-aut-sei=Matsui
en-aut-mei=Hideki
kn-aut-name=松井秀樹
kn-aut-sei=松井
kn-aut-mei=秀樹
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生理学
en-keyword=febrile seizures
kn-keyword=febrile seizures
en-keyword=animal model
kn-keyword=animal model
en-keyword=Scn1a gene
kn-keyword=Scn1a gene
en-keyword=generalized epilepsy with febrile seizures plus
kn-keyword=generalized epilepsy with febrile seizures plus
en-keyword=severe myoclonic epilepsy of infancy
kn-keyword=severe myoclonic epilepsy of infancy
END

start-ver=1.4
cd-journal=joma
no-vol=45
cd-vols=
no-issue=12
article-no=
start-page=3045
end-page=3066
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1933
dt-pub=19331231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimentelle Studien ?ber die Erm?dung II. Mitteilung. ?ber den Einfluss der Erm?dung auf die Antik?rperbildung
kn-title=疲勞ニ關スル實驗的研究（第2囘報告）疲勞ノ抗體産生ニ及ボス影響ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Der Einfluss der Erm?dung auf die Antik?rperbildung wurde schon von vielen Forschern untersucht. Einige meinten, dass die Erm?dung auf die Antik?rperbildung sch?dich einwirke, die anderen behaupteten, dass sie keine Wirkung habe, und noch andere erkl?rten, dass sie eine gute Wirkung aus?be. So gibt es bis jetzt noch keine ?bereinstimmung in den Meinungen, weil die Erm?dungseinrichtung, die vorher f?r diese Experimente angewendete Tretm?hle, f?r Kaninchen oder Meerschweinchen nicht geeignet ist, da die Versuchstiere in dieser nur passive mit der Umdrehung der Tretm?hle und nicht freiwillige und aktive Bewegung ausf?hren k?nnen. Deshalb untersuchte ich den Einfluss der Erm?dung auf die Antik?rperbildung mit meiner eigenen Erm?dungseinrichtung und erzielte folgende Resultate. I) Der normale Komplementgehalt des Meerschweinchens wird unter dem Einfluss der akuten und chronischen Erm?dung nicht ver?ndert. II) Die akute und chronische Erm?dung vermag bei Kaninchen die normalen H?moagglutinine gegen H?hnerrote nicht zu beeinflussen III) Die Antik?rperbildung bei H?moagglutinin gegen H?hnerrote scheint durch die akute Erm?dung nicht beeinflusst zu werden. IV) Der Einfluss der chronischen Erm?dung auf die Immunk?rper von Kaninchen ist je nach der Erm?dungsweise und der Injektionszeit, wie folgt, verschieden: 1) Wenn man das Kaninchen sofort nach der Antigeninjektion in der Erm?dungseinrichtung 5 Tage (an jedem Tage 5 Stunden) laufen l?sst, so ist die Steigerung des Agglutininwertes nach 3 Tagen deutlich sichtbar, und dieser hohe Agglutininwert bleibt lange nach Experiment bestehen. 2) Wenn das Antigen bei vorher erm?deten Kaninchen injiziert wird, so bleibt der Agglutininwert unver?ndert. 3) Wenn man das Kaninchen am 3. Tage nach der Antigeninjektion laufen l?sst, so ist eine geringe Steigerung des Agglutinins zu bemerken. 4) Wenn man das Kaninchen am 7. Tage nach der Antigeninjektion laufen l?sst, so wird der Agglutininwert gar nicht ver?ndert. Kurz gesagt, die Bildung des Antih?hnerrotenagglutinins wird gef?rdert, wenn die Erm?dung sofort od. kurze Zeit nach der Immunisierung beginnt. V) Die Antik?rperbildung bei dem Anticoliagglutinin, H?molysin und Bakteriolysin scheint durch die Erm?dung in gleicher Weise ein wenig gef?rdert zu werden. VI) Das Aufsteigen des Pr?zipitinwertes durch die Erm?dung ist nach der Antik?rperverd?nnungsmethode nachweisbar, nicht jedoch nach der Uhlenhuth'schen Methode. VII) Als man bei immunisierten Kaninchen das Blutbild der Leukozyten und die Antik?rperbildung gleichzeitig untersuchte, bemerkte man eine Vermehrung der Leukozyten, bsd. eine solche der pseudoeosinophilen vielkernigen Leukozyten. Durch Fortsetzung der Erm?dung konnte man im Blute das Auftreten der jugendlichen Form von Leukozyten, mit anderen Worten die Arnethsche Kernverschiebung nach links beobachten. VIII) Aus obigen Tatsachen ersieht man, dass die Antik?rperbildungskraft der Tiere vermehrt wird, wenn das H?matopoetische System der Tiere durch Erm?dung gereizt wird.
en-copyright=
kn-copyright=

en-aut-name=IshiharaTadayuki
en-aut-sei=Ishihara
en-aut-mei=Tadayuki
kn-aut-name=石原忠之
kn-aut-sei=石原
kn-aut-mei=忠之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=45
cd-vols=
no-issue=12
article-no=
start-page=3015
end-page=3044
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1933
dt-pub=19331231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimentelle Studien ?ber die Erm?dung bei Kaninchen und Meerschweinchen I. Mitteilung. ?ber den Einfluss der Erm?dung auf die Blutbestandteile
kn-title=疲勞ニ關スル實驗的研究（第1囘報告）疲勞ノ家兎血液諸成分ニ及ボス影響ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Vorliegende Studien ?ber die Erm?dung wurden haupts?chlich mit Menschen, Hunden und kleineren Tieren angestellt, da die angegebene Einrichtung zum Herbeif?hren der Erm?dung f?r Kaninchen und Meerschweinchen infolge der Gewohnheit der Versuchstiere ungeeignet ist. Die gebr?uchlichste Einrichtung ist die Tretm?hle. Bei Drehung der Tretm?hle bewegen sich die Versuchstiere nur passiv und unwillk?rlich, daher ergibt sich ein Resultat, das weit anders ausf?llt als das bei eigener aktiver Bewegung anderer Tiere. Hierauf habe ich einen verbesserten Apparat (Photographie) eingerichtet, bei dem die Versuchstiere wie Kaninchen und Meerschweinchen bei willk?rlicher Bewegung einen schiefen Ledergurt zu laufen gezwungen werden. Mit diesem kann man die Bewegungszeit und die Laufstrecken genau angeben. In dieser Einrichtung habe ich Kaninchen sich erm?den lassen und dabei Blutk?rperchen, Blutzucker, Alkalireserve, Viskosit?t des Blutes und Serumcholesterin untersucht. Dieselben Experimente habe ich auch bei hoher Temperatur und nasser W?rme angestellt. Folgendes sind die experimentellen Resultate. I) Bei erm?deten Kaninchen: 1) Nach 3 st?ndigem Laufen (3600m) ist nur eine unbedeutende Ver?ndrung in der Zahl der roten Blutk?rperchen und im H?moglobingehalt zu bemerken. 2) Die Zahl der weissen Blutk?rperchen vermehrt sich schon nach 1 st?ndigem Laufen (1200m) best?ndig. Der Grad der Vermehrung geht mit der St?rke der Erm?dung parallel. Das Blutbild geh?rt zur Pseudoeosinophilie. 3) Der Blutzuckergehalt vermindert sich bei 30 Minuten Laufzeit (Laufweite ca. 600m) um ca. 20% (In einem Falle kommt schwache Hyperglyk?mie vor), bei 60 Minuten um ca. 35%, bei 120 and 180 Minuten um 40-60%. Der Grad der Vermehrung geht mit dem Grad der Erm?dung ungef?hr parallel. 4) Die Alkalireserve vermindert sich um 30-50% direkt nach der Erm?dung, wird aber in wenigen Stunden wieder normal. II) ?ber die Erm?dung von Kaninchen bei hoher Temperatur (45-50℃) nach 1 st?ndigem Laufen. 1) Die Zahl der weissen Blutk?rperchen vermehrt sich, und zwar st?rker als bei der gew?hnlichen Erm?dung. Im Gegensatz dazu vermindert sich aber die Zahl der weissen Blutk?rperchen in dem Fall, wo das Kaninchen nach der Erm?dung stirbt. 2) Es ist eine Verminderung des Blutzuckergehaltes zu bemerken, Im Verlauf der Verminderung wird oft infolge der Erhitzung eine vor?bergehende Hyperglyk?mie herbeigef?hrt. In einem Falle tritt aber auch Hyperglyk?mie auf, wobei das Kaninchen nach der Erm?dung zu grunde geht. 3) Die Alkalireserve vermindert sich st?rker als bei der gew?hnlichen Erm?dung, und die Erholung erfolgt nicht schnell, d. h. die Acidosis ist st?rker und dauerhafter als bei der gew?hnlichen Erm?dung von Kaninchen. III) ?ber die Erm?dung von Kaninchen bei hoher Feuehtigkeit (relative Feuchtigkeit: 90-95%). 1) Nach 1-3 st?ndigem Laufen ist nur eine unbedeutendere Ver?nderung in der Zahl der weissen Blutk?rperchen und im Blutzucker als bei dem gew?hnlichen Erm?dungsversueh zu bemerken. 2) Die Erholung der Alkalireserve erfolgt nicht schnell bei 3 st?ndigem Laufen, d. h. die Acidosis ist dauerhafter als bei der gew?hnlichen Erm?dung. IV) Wenn der Erm?dungsversueh bei einem Tier mehrere Tage lang fortdauernd wiederholt wird, so sieht man die sog. Arnethsche Kernverschiebung nach links im Blutbild: am 3. Tage erst erscheint die jugendliche Form des weissen Blutk?rperchens in 1.0%, am 5. Tage in 1.5-3.0%. V) Die Viskosit?t des Blutes vermehrt sich bie der Erm?dung. Der vermehrungsgrad und die St?rke der Erm?dung gehen beinahe parallel; die Viskosit?t ver?ndert sich wenig bei 30-60 Minuten Laufzeit, vermindert sich aber um 27.0-68.0% bei 3-6 Stunden Laufzeit und bedarf mehr als 20 Stunden zu ihrer Wiederherstellung. Die Viskosit?t geht bei der Erm?dung nicht immer parallel mit dem H?moglobingehalt und der Zahl der roten Blutk?rperchen. VI) Der Serumcholesteringehalt, bsd. der freie Cholesteringehalt vermehrt sich mit der Erm?dung. Der Vermehrungsgrad geht mit dem Grad der Erm?dung ungef?hr parallel. Der Gehalt vermehrt sich n?mlich wenig bei 30-60 Minuten Laufzeit, aber um 14-42mg/dl bei 3-6 Stunden Laufzeit.
en-copyright=
kn-copyright=

en-aut-name=IshiharaTadayuki
en-aut-sei=Ishihara
en-aut-mei=Tadayuki
kn-aut-name=石原忠之
kn-aut-sei=石原
kn-aut-mei=忠之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=10
article-no=
start-page=2660
end-page=2677
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1934
dt-pub=19341031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber den Einfluss der Temperatur auf die Immunund Kolloidreaktion
kn-title=温度ノ免疫竝ニ膠質反應ニ及ボス影響ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=?ber die passendste Temperatur f?r die Bakterienagglutination werden seit langem von zahlreichen Forschern Untersuchungen angestellt. Die geeignetste Temperatur f?r die Bildung grosser Flocken ist nach Kafka, Venema, Stern u. a. 37°C, nach Weil, Sadler, van Loghem, Porges u. a. 50-55°C, nach Gaehtgens weniger als 37°C, nach Asakawa 0°C: so bestehen in dieser Frage noch grosse Meinungsverschiedenheiten. Die gew?hnliche Methode zur Agglutininuntersuchung pflegt meist nach 2 Stunden langer Digerierung bei 37°C und in Zimmertemperatur oder bei 0°C das Objekt ruhig liegen zu lassen und am n?chsten Tage zu pr?fen. Aber bei dieser Methode st?sst man oft auf undeutliche Reaktionen. Deshalb wird zur Messung des Agglutininwertes gew?hnlich das Agglutinoskop als Hilfsmittel gebraucht. Es ist sowohl nach der praktischen, als auch nach der theoretischen Seite hin interessant, dass durch Temperaturwirkung die Flockenbildung bei Agglutinin, Pr?zipitin und Kolloidreaktionen und auch die Vergr?sserung der Flocken oder Vermehrung der Flockenbildung m?glich ist. Zuerst habe ich die passendste Temperatur und Zeitdauer f?r die deutliche Flockenbildung bei Bakterienagglutininen bestimmt und die Grosse der Flocken mikroskopisch gemessen. Ferner habe ich auch bei der Pr?zipitation und der Kolloidreaktion (Kongorot und Janusgr?n) dieselben Experimente angestellt und bin zu folgendem Schluss gelangt: 1) Die passendste Temperatur f?r die Colibazillenagglutination ist 45°C, die geeignetste Zeitdauer 24 Stunden. Bei dieser Methode kann man die Bildung der gr?beren Flocken und eine ?usserst klare Reaktion beobachten. 2) Mit dieser Methode kann man den Agglutininwert auch mit blossem Auge leicht bestimmen. 3) Sowohl bei der Pr?zipitation und der Kolloidreaktion wie auch bei der Agglutination jst es zu bemerken, dass eine hohere Temperatur f?r die Flockenbildung besser ist als eine niedrigere, was bei l?ngerer Zeitdauer um so deutlicher wird. Es gibt jedoch eine Grenze zur Flockenbildung und man sieht keinen Unterschied zwischen 40-60°C, bei ?ber 70°C bemerkt man sogar eine Verminderung der Flockenbildung.
en-copyright=
kn-copyright=

en-aut-name=IshiharaTadayuki
en-aut-sei=Ishihara
en-aut-mei=Tadayuki
kn-aut-name=石原忠之
kn-aut-sei=石原
kn-aut-mei=忠之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=9
article-no=
start-page=2339
end-page=2359
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1934
dt-pub=19340930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimentelle Studien ?ber die Anaphylaxia inversa bei Haninehen nach Blutdruckmessung
kn-title=家兔逆過敏症ニ關スル實驗的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Seit die passive Anaphylaxie nach Nicolle, Friedmann, Otto u. a. best?tigt wurde, sind die Beziehungen zwischen anaphylaktigchem Anbik?rper und Pr?zipitin viel klelrer geworden. Wenn die Anaphylaxie durch die Bindung zwischen Pr?zipitin und Antigen herbeigef?hrt wird, so ist es klar, dass man umgekehrt die Uberempfindlichkeit auch durch die Reinjektion des Immunserums erreichen kann, indem man das Antigen erst intraven?s injiziert. Es gibt aber bis heute nur wenige Arbeiten ?ber diese sog. Anaphylaxia inversa, besonders beim Kaninchenversuch, weil bei diesem zur Sensibilisierung eine gr?ssere pr?zipitinmenge als beim Meerschweinchen ben?tigt Wird. Darum habe ich, die bekannte Erscheinung der Blutdrucksenkung als Merkmal benutzend, die Anaphylaxia inversa systematisch untersueht und folgende Resultate erzielt. 1) Die Anaphylaxia inversa wird auch bei Kaninchen durch Blutdruckmessung sicher nachgewiesen. 2) Zur Entstehung der Anaphylaxia inversa bei Kaninchen sind mehr als 25 pr?zipitineinheiten im Blut des Versuchstieres erforderlioh, die bei normaler passiver Anaphylaxie eine typische Drucksenkung erzeugen konnen. 3) Die minimale sensibilisierende Antigenmenge, durch welche die Anaphylaxia inversa erregt werden kann, stimmt ungef?hr mit dev der Bindungszone entsprechenden Menge von reinjiziertem Immunserum uberein 4) F?r die Inkubationszeit. bei det Anaphylaxia inversa gelten 5 Minuten bis 48 Stunden als am passendsten. 5) Wahrend bei der normalen passiven Anaphylaxie keine Blutdrucksenkung innerhalb von 5 Minuten zu beobachten ist, ist diese Erscheinung jedoch bei dem Fall, wo man eine gleiche Menge von dem Antik?rper und dem Antigen auf verkehrte Weise gebiaucht, n?mlich bei der Anaphylaxia inversa, in einem Intervall von 5 Minuten deutlich zu bemerken. 6) Wen man Antigen intraperitoneal od. subcutan sensibilisiert, so kann man auch die Anaphylaxia inversa beobachten. 7) Die Antianaphylaxie ist auch bei der Anaphylaxia inversa bei Kaninchen zu beobachten.
en-copyright=
kn-copyright=

en-aut-name=IshiharaTadayuki
en-aut-sei=Ishihara
en-aut-mei=Tadayuki
kn-aut-name=石原忠之
kn-aut-sei=石原
kn-aut-mei=忠之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=47
cd-vols=
no-issue=5
article-no=
start-page=1123
end-page=1142
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1935
dt-pub=19350531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Vergleichungsstudien ?ber die verschiedenen Trockenmittel
kn-title=各種除濕劑ノ比較研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Um praktisch die Wirkung der Entfeuchtung bei geschlossenem Raum zu studieren, stellten wir in das dicht geschlossene Laboratoriumzimmer einen mit Papier ?berzogenen Glaskasten (1cm) ein, mit dem man eine bestimmte Temperatur und Feuchtigkeit erzeugen kann. Die relative Feuchtigkeit im Versuchskasten wird durch Einf?hrung von Wasserdampf auf ?ber 90% gesteigert, dann wird eine bestimmte Menge von verschiedenen Trockenmitteln (Calcium chloratum purum f?r Analyse von Isizu, Calcium chloratum siccum f?r Trocknung, Calcium chloratum siccum neutrale von Merck, I. D. Trockenmittel, Adsole, Schwefels?ure, und Wolle) in den Kasten eingef?hrt. Die Wirkung der Trockenmittel wird zeitlich durch verschiedene Psychrometer (Augustsche, Assmannsche, Fuessche, Lambrechtsche Psychrometer) untersucht. Dabei werden die Katawerte mit einem Wett-katathermometer bestimmt. Da die relative Feuchtigkeit von der Ver?nderung der Temperatur abh?ngt, wurden alle Untersuchungen immer in einer bestimmten Temperatur ausgef?hrt. Diese Versuche wurden im Sommer (bei 30 C) und im Winter (bei 10 C) angestellt, weil die Wirkung der Trockenmittel durch die Temperatur mehr oder minder beeintr?chtigt wird. 1) Bei hoher Temperatur im Sommer, d. h. bei 30 C, zeigt sich Calcium chloratum in bezug auf Lufttrockung am st?rksten, dann folgen I. D. Trockenmittel, Adsole, Schwefels?ure und Wolle. 2) Bei niedriger Temperatur im Winter, d. h. bei 10 C, abfeuchtet Calcium chloratum am st?rksten, es folgend I. D. Trockenmittel und Adsole. Unter Calcium chloratum wirkt als Trockenmittel das Calcium chloratum purum f?r Analyse am st?rksten, diesem folgt Calcium chloratum siccum neutrale von Merck, Calcium chloratum siccum steht hinter diesen ziemlich weit zur?ck. 3) Es ist bemerkenswert, dass die Absorptionskraft f?r die Luftfeuchtigkeit haupts?chlich von der Fl?chengr?sse der Absorptionsmittel abh?ngig ist. Wenn man also gekl?mpftes Calcium chloratum siccum fein zerbricht, so steigt seine Absorptionskraft auf die des Calcium chloratum purum f?r Analyse. 4) In der gleichen Weise kann man durch verteilte Anwendung des Trockenmittels viel bessere Resultate erzielen als bei einmaligem Gebrauch desselben. 5) Die Trockenmittel zeigen ihre Absorptionskraft bei hoher Temperatur im Sommer deutlich st?rker als bei niedriger Temperatur im Winter.
en-copyright=
kn-copyright=

en-aut-name=OhtaharaKazuyoshi
en-aut-sei=Ohtahara
en-aut-mei=Kazuyoshi
kn-aut-name=大田原一祥
kn-aut-sei=大田原
kn-aut-mei=一祥
aut-affil-num=1
ORCID=

en-aut-name=IshiharaTadayuki
en-aut-sei=Ishihara
en-aut-mei=Tadayuki
kn-aut-name=石原忠之
kn-aut-sei=石原
kn-aut-mei=忠之
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學衛生學教室

affil-num=2
en-affil=
kn-affil=岡山醫科大學衛生學教室
END

start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=1
article-no=
start-page=71
end-page=87
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1939
dt-pub=19390131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimentelle Untersuchungen ?ber die Blutz?cker und Glykogen-yer?nderungen bei den akuten Bauchfellentz?ndungen. I. Mitteilung: Blutz?cker.
kn-title=實驗的急性腹膜炎ト血糖竝ニ糖原（第1編）血糖消長ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Der Blutz?cker wurde bei den experimentellen akuten Bauchfellentz?ndungen des Meerschweinchens und des Haninchens stadiumweise nach der Hagedorn-Jensen'schen Methode bestimmt. Den Tieren wurde von 24 Stunden ab vor der Injektion der Bazillen in die Bauchhohle bis zum Tode keine Nahrung zugefuhrt. Heine Ergebnisse sind kurz zusammengefasst folgeude: 1) Nach der Injektion der Bazillen in die Bauchhohle steigt der Blutz?cker. Je schwerer der Krankheitsverlauf ist, desto starker und mehr anhaltender ist die Blutzuckersteigerung. 2) Bei leiehtem Verlauf wird die Blutzuekermenge nach einigen Stunden wiederhergestellt. Danach zeigt die Blutz?ckerkurve keine nennenswerte Ver?nderungen. 3) Bei mittelschwerem Verlauf wird sie beinahe an der Mitte des ganzen Verlaufs wiederhergestellt. Danach steigt der Blutz?cker welter und welter herab. Vor dem Tode ist die Blutz?ckerabsteigung sehr deutlich. (bis ca. 30mg%) 4) Bei schwerstem Verlauf ist die Blutz?ckersteigerung sehr stark und lange anhaltend. Nur vor dem Tode ist die Neigung zu der Absteigung nachweissbar. 5) Gerade vor dem Tode steigt der Blutz?cker auf alle Falle herab. Diese Absteigung ist am deutlichsten bei mittelschwerem Verlauf siehtbar.
en-copyright=
kn-copyright=

en-aut-name=IshiharaKanichi
en-aut-sei=Ishihara
en-aut-mei=Kanichi
kn-aut-name=石原貫一
kn-aut-sei=石原
kn-aut-mei=貫一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=2
article-no=
start-page=233
end-page=248
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1940
dt-pub=19400229
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimentelle Untersuchungen ?ber die Blutzueker- und Glykogenver?nderungen bei den akuten Bauchfellentz?ndungen (II. Mitteilung.) Leber- und Nuskelglykogen
kn-title=實驗的急性腹膜炎ト血糖竝ニ糖原（第2編）肝竝ニ筋糖原量ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Das Leber- und Muskelglykogen wurde bei den experimentellen akuten Bauchfellentz?ndungen des Meerschweinchens und des Kaninchens nach der Iwasaki-Mori'schen Methode bestimmt. Das Leberglykogen wurde noch histologisch nach der Best'schen-Karminf?rbung untersucht. Gleich bei den Blutzuckeruntersuchungen wurde auch bei diesen Untersuchungen den Tieren w?hrend der Experimente keine Nahrung zugef?hrt. Meine Ergebnisse sind kurz folgendermassen zusammengefasst: 1) Die Glykogengehalte der Leber und des Muskels nehmen bei den Kontrollen oder den Inanitionen leichten Grades ab. 2) Bei Peritonitis nehmen sie st?rker als bei den Kontrollen ab. 3) Der Leberglykogenverlust bei Peritonitis ist chemisch und histologisch deutlich nachweisbar, und ihre Geschwindigkeit ist desto schneller, je schwerer der Krankheitsverlauf ist. 4) Gerade vor dem Tod sind die Leberglykogengehalte der verschiedenen Tiere, deren Krankheitsverlaufe mannigfaltig sind, fast gleichwertig und ganz gering. Die Leberglykogenmenge des gestorbenen Tieres ist am geringsten. 5) Die Muskelglykogenabnahme bei Peritonitis ist leichtgradig oder fast nicht nachweisbar, also spielt der Einfluss der Peritonitis selbst eine nicht so grosse Rolle wie andere Faktoren, z.B. die Muskelbewegung. 6) Die Abnahme des Leberglykogens geht fast parallel zur Zunahme des Blutzuckers im Laufe der Zeit der Peritonitis.
en-copyright=
kn-copyright=

en-aut-name=IshiharaKanichi
en-aut-sei=Ishihara
en-aut-mei=Kanichi
kn-aut-name=石原貫一
kn-aut-sei=石原
kn-aut-mei=貫一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=10
article-no=
start-page=2165
end-page=2190
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1941
dt-pub=19411031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber Retothelsarkom
kn-title=淋巴性網皮肉腫ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bericht ?ber 7 Falle von Retothel-oder Reticulosarkom, welches der Verf. seit 1937 in der Tsuda-Klinik beobachten konnte, und zwar 6 Falle davon bei M?nnern und 1 F?lle bei einer Frau. Das Alter lag zwischen 49 und 66 Jahren. Der prim?re Herd sass in 3 F?llen auf dem Hals, in je einem der ?brigen F?lle in der Inguinalgegend, im Diediastinum, im Retroperitoneum und schliesslich im Oberschenkel. Der Verf. weist auf die Seltenheit des zuletzt genannten Falles hin in bezug auf die Ausgangsstelle des Sarkoms. In den meisten Fallen wurde die klinische Diagnose, auf Lymphosarkom gestellt. Als Behandlnng wurde f?r 6 F?lle, welche fur die Operation zu sp?t waren, intratumorale Applikation der Radiumnadel bzw. R?ntgenbestrahlung ausgef?hrt. In dem einen ?brigen Fall wurde, nachdem ein Teil des erkrankten Gewebes entfernt worden war, R?ntgenbestrahlung vorgenommen. In allen F?llen wurden vor?bergehende Verkleinerung des Tumors, Besserung der Drucksymptome usw. wahrgenommen. 5 Falle davon aberverschlimmerten sich wieder und fuhrten verh?ltnism?ssig schnellen Laufes zum Tode.Von den ?brigen 2 F?llen l?sst sich nur so viel sagen, dass sie jetzt meist gesund sind, sonst nichts Besonderes, da sie erst vor kurzem zur Behandlung kamen.
en-copyright=
kn-copyright=

en-aut-name=IshiharaKan-ichi
en-aut-sei=Ishihara
en-aut-mei=Kan-ichi
kn-aut-name=石原貫一
kn-aut-sei=石原
kn-aut-mei=貫一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=10
article-no=
start-page=2137
end-page=2164
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1941
dt-pub=19411031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimentelle Untersuchungen ?ber die Ver?nderungen von der Blutmilchs?ure und dem CO(2) gehalt des Blutplasmas bei den akuten Bauchfellentz?ndungen
kn-title=實驗的急性腹膜炎ニ於ケル血中乳酸量竝ニ血漿CO(2)含有量ノ消長ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bei Kaninchen und Hundenwurde auf experimentellem Wege akute Bauchfellentz?ndung hervorgerufen, um den Gehalt des Blutes an Milchs?ure und CO(2) festzustellen, und zwar die Milchs?ure durch Anwendung der Takahata-Kumeschen Methode, CO(2) durch Benutzung des van Slykeschen Verfahrens. Ebenso wie bei Blutzuckeruntersuchung wurden auch im vorliegenden Versuch den Tieren alle Nahrungen entzogen. Die Ergebnisse waren wie folgt: 1) Im Kontrollversuch, in welchem physiologisehe Kochsalzl?sung in der Menge von ca. 20,0ccm in die Bauchh?hle der Tiere eingef?hrt worden war, wies das Blut weder an Gehalt der Milchr?ure noch an Gehalt von CO(2) keine nennenswerte Ver?nderung auf. 2) Bei den Tieren, bei denen eine einfache Laparotomie mit einem kleinen Schnitt innerhalb von 2 oder 3 Minuten ausgef?hrt wurde, zeigte das Blutplasma im Laufe von 2 bis 3 Stunden nach der Operation eine geringe Vermehrung an Gehalt von CO(2). An Gehalt der Milchs?ure trat im Blut keine erhebliche Ver?nderung auf. 3) Bei schwerer Peritonitis erfuhr die Menge der Milchs?ure im Blut eine so auaserordentlich rapide und hochgradige Steigerung, dass ihr Endwert sogar ca. 100mg% und mehr betrug. 4) Wenn die Peritonitis nicht schwerer Natur war, zeigte ein Teil der Tiere im Fr?hstadium an Gehalt der Milchs?ure keine nennenswerte Ver?nderung, w?hrend ein anderer Teil der Tiere im Laufe von 2-3 Stunden nach der Operation eine m?ssige Vermeheung aufwies. Im Endstadiurn jedoch nahm die Milchs?ure in allen F?llen von diesem nichtschwerenKrankheitsbild quantitativ allm?hlich zu. Je schwerer die Krankheit war, um so schneller und h?hergradig trat die Vermehrung auf. 5) Auch die quantitative Steigerung der Milchs?ure im Fr?hstadium tart um so h?hergradig und l?nger andauernd auf, je leichter die Bakterien bezw. Bakteriengifte vom Peritonaeum resorbiert werden konnten. 6) Ein nachtr?glicher Versuch ergab, dass die Kurven der quantitativen Schwankungen der Blutmilchs?ure bei akuter Pankreasnekrose und akutem Ileus mit denjenigen Kurven ?bereinstimmten, welche bei m?ssig akuter Peritonitis, bei der die Milchs?ure im Fr?hstadium keine quantitative Steigerung zeigte, verzeichnet wurden. Bei akuter Pankreasnekrose jedoch dauerte die anf?ngliche Absteigerung der Kurven viel l?nger als sonst, so dass die Aufsteigerung der Kurven im Endstadium auch um so sp?ter auftrat, was einen niedrigeren Endwert der Milchs?ure mit sich brachte. 7) Der Gehalt des Blutplasmas an CO(2) nahm bei Peritonitis allm?hlich ab, und zwar um so schneller und st?rker, je schwerer die Krankheit auftrat. Bei der schwersten Form dieser Krankheit wurde der Endwert von CO(2) bis zu ca. 20Vol% herabgesetzt. Mit anderen Worten also, dass bei akuter Peritonitis eine Acidosis auftrat, deren St?rke zu den Krankheitssymptomen parallel stand.
en-copyright=
kn-copyright=

en-aut-name=IshiharaKan-ichi
en-aut-sei=Ishihara
en-aut-mei=Kan-ichi
kn-aut-name=石原貫一
kn-aut-sei=石原
kn-aut-mei=貫一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=69
cd-vols=
no-issue=10
article-no=
start-page=2531
end-page=2544
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1957
dt-pub=19571031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Pathogenic Agent of Infectious Hepatitis in Okayama Prefecture I: Studies on the Skin Reaction by Isolated Virus
kn-title=岡山県下に発生した流行性肝炎 特に病原体に関する研究 第一編 分離病毒による皮膚反応に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By the inoculation of the antigen prepared from the virus-infected animal organs into the hepatitis patients in Kagato district and the healthy men in other districts, a kind of allergic skin reaction was observed which were specific to a mild or subclinical infection of infectious hepatitis. In order to test the practical value of this skin reaction, the author performed many experiments and obtained the following results: 1) Of all the antigens prepared from various animal organs or tissues, the antigen from liver of the mouse inoculated with Ishihara strain showed the most effective result, and was used in the subsequent experiments. 2) In the forearm, 0.1 cc of the saline solution of antigen was inoculated intracutaneously. The test was tried on 375 hepatitis patients and 125 healthy men, and the frequency curve of the size of flush area was taken to estimate the standard size for the judgement of the result of skin reaction. That over 10 mm in diameter was determined as positive and that under 9.5 mm as negative. 3) The maximum of flush area was reached 20 hours after the inoculation of antigen and lasted till 28 to 32 hours, and it seemed reasonable to decide the result of reaction 24 hours after the inoculation. 4) As the disease became chronic, the specificity and appearance of reaction falled. 5) No noticeable side effect was produced by the inoculation of this antigen. 6) Judged from the frequency curve of the size of flush area, the specificity of the reaction seemed to be higher in the early stage of the disease than in the convalescent stage.
en-copyright=
kn-copyright=

en-aut-name=YokoyamaHaruyuki
en-aut-sei=Yokoyama
en-aut-mei=Haruyuki
kn-aut-name=横山治之
kn-aut-sei=横山
kn-aut-mei=治之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=69
cd-vols=
no-issue=1
article-no=
start-page=203
end-page=222
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1957
dt-pub=19570131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Susceptibility of Fowls to Hepatitis Virus Report 2: Experiments of chronic infection
kn-title=各種鳥類に対する流行性肝炎病毒の感受性に関する研究 第II編 特に慢性化実験に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to cause chronic infection, each virus of Ishihara, Kanamitsu and Noda strains was inoculated into 37 canaries (Serinus canaria), 33 siskins (Chloris sinica minor T. & S.) and 20 love-birds (Uroloncha domestica). During this chronic infection course of about 6 months, the author studied the interrelation between the pathologic changes of the liver and lung and the white cell count and blood picture. By the intrapectoral inoculation of the emulsion of virus-inoculated mouse liver or embryonated egg, though a few lethal cases were observed, in most cases there was established the so-called inapparent infection which showed clearly the tendency of chronic infection. Remarkable leucopenia was observed at high percentage in the early stage of infection. Severe increase of atypical leucocytes, which happened in the same stage as that of leucopenia, was a characteristic change together with the appearance of the vacuole-degenerated leucocytes. In the liver, various remarkable changes resembling to thoes in the hepatitis liver of human being appeared: round cell infiltration in the periportal connective tissue, liver cell degeneration full of varieties such as nodules and necrotic changes and the localized necrosis scattered in the intermediate parts of acini. Especially in the lethal cases of siskins (Chloris sinica minor T. & S.) which showed many lethal cases, very severe necrosis and cell infiltration were observed. This fact seems to suggest that chloris sinica minor T. & S. is the most susceptible of all kinds of tested fowls. On the other hand, in the lung there were observed the mesodermal cell infiltration, interalveolitis, hemorrhage around bronchi, alveoli and blood vessels. These changes in the lung appeared later than those in liver, and persisted for 6 months.
en-copyright=
kn-copyright=

en-aut-name=OnizukaRyotaro
en-aut-sei=Onizuka
en-aut-mei=Ryotaro
kn-aut-name=鬼塚良太郎
kn-aut-sei=鬼塚
kn-aut-mei=良太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=69
cd-vols=
no-issue=1
article-no=
start-page=191
end-page=202
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1957
dt-pub=19570131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Susceptibility of Fowls to Hepatitis Virus Report 1: Successive transmission and determination of infection titer
kn-title=各種鳥類に対する流行性肝炎病毒の感受性に関する研究 第I編 継代並び感染価測定実験に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to study the possibility of successive transmission and the determination of infection titer of hepatitis virus in fowls, the author used six strains of virus, Ishihara Kanamitsu, Noda, Ogawa, Morimoto, and Aomori stains, which were isolated from the patient materials by the successive transmission through mice and embryonated eggs in our laboratory. As the criteria of infection, the author took the hepatitis-specific pathologic changes of the liver and lung. Of the fowls tested, infection was the severest in Chloris sinica minor T. & S, and became milder in the following order: Chloris sinica minor T. & S. Uroloncha domestica, Serinus canaria, Passer montanus saturatus Stejeneger, Emberiza rustica latifascica Portenko, Pyrrhula pyrrhula griseiventris Lafresnaye, Emberiza cicoides ciopsis Bonaparte of Passeres and Fringillid?, and zosterops palpebrosa japonicaT. & S. of Zosteropid?. In each fowl, the histological changes became severer with the successive transmissions, and seemed to be fixed at about the fifth transmission. As to the determination of infection titer, the most remarkable pathologic changes were observed around 10(-9)× in Serinus canaria and 10(-10)× in Uroloncha domestica. The tests of reversion of virus from fowls to mice were positive in all cases.
en-copyright=
kn-copyright=

en-aut-name=OnizukaRyotaro
en-aut-sei=Onizuka
en-aut-mei=Ryotaro
kn-aut-name=鬼塚良太郎
kn-aut-sei=鬼塚
kn-aut-mei=良太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=64
cd-vols=
no-issue=5
article-no=
start-page=345
end-page=349
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=201010
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Intraoral Vertical Ramus Osteotomy Improved the Stomatognathic Function in an Elderly Patient with Mandibular Protrusion:A Case Report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This article reports the successful surgical-orthodontic treatment of an elderly patient with dentofacial deformity and signs and symptoms of temporomandibular disorder (TMD). The patient was a 63-year-old woman with a concave profile due to mandibular protrusion. To correct skeletal deformities, the mandible was posteriorly repositioned by employing intraoral vertical ramus osteotomy (IVRO) following presurgical orthodontic treatment. After active treatment for 31 months, the facial profile was significantly improved and satisfactory occlusion was achieved. In addition, TMD symptoms of clicking sounds on the left side and difficulty in mouth opening were resolved. Regarding the findings of magnetic resonance imaging, anterior disc displacement in the opening phase was improved in the temporomandibular joint on the left side. Furthermore, stomatognathic functions were also improved without any aggravation of age-related problems. In conclusion, surgical repositioning of the mandible using IVRO leads to both morphological and functional improvements even in elderly patients.
en-copyright=
kn-copyright=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KurodaShingo
en-aut-sei=Kuroda
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KawanabeNoriaki
en-aut-sei=Kawanabe
en-aut-mei=Noriaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Takano-YamamotoTeruko
en-aut-sei=Takano-Yamamoto
en-aut-mei=Teruko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamashiroTakashi
en-aut-sei=Yamashiro
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Orthodontics and Dentofacial Orthopedics, The University of Tokushima Graduate School of Oral Sciences

affil-num=3
en-affil=
kn-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry

affil-num=5
en-affil=
kn-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=elderly patient
kn-keyword=elderly patient
en-keyword=orthodontics
kn-keyword=orthodontics
en-keyword=temporomandibular disorder
kn-keyword=temporomandibular disorder
en-keyword=intraoral vertical ramus osteotomy
kn-keyword=intraoral vertical ramus osteotomy
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=1
article-no=
start-page=19
end-page=47
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=195912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=On Riemannian manifolds admitting a concircular transformation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaShigeru
en-aut-sei=Ishihara
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TashiroYoshihiro
en-aut-sei=Tashiro
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Tokyo Gakugei University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=2
article-no=
start-page=108
end-page=117
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080921
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication. In this article, we report successfully isolating primary cultures of osteocytes from chick calvaria, and, using anti-connexin 43 immunocytochemistry, demonstrate gap junction distribution to be comparable to that found in vivo. Next, we demonstrate the functionality of the gap junctions by (1) dye coupling studies that showed the spread of microinjected Lucifer Yellow from osteoblast to osteocyte and between adjacent osteocytes and (2) analysis of fluorescence replacement after photobleaching (FRAP), in which photobleaching of cells loaded with a membrane-permeable dye resulted in rapid recovery of fluorescence into the photobleached osteocyte, within 5 min postbleaching. This FRAP effect did not occur when cells were treated with a gap junction blocker (18 alpha-glycyrrhetinic acid), but replacement of fluorescence into the photobleached cell resumed when it was removed. These studies demonstrate that gap junctions are responsible for intercellular communication between adjacent osteocytes and between osteoblasts and osteocytes. This role is consistent with the ability of osteocytes to respond to and transmit signals over long distances while embedded in a calcified matrix. </p>

en-copyright=
kn-copyright=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=RisHans
en-aut-sei=Ris
en-aut-mei=Hans
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurshidSakhr A.
en-aut-sei=Murshid
en-aut-mei=Sakhr A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SugawaraYasuyo
en-aut-sei=Sugawara
en-aut-mei=Yasuyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamamotoTeruko Takano
en-aut-sei=Yamamoto
en-aut-mei=Teruko Takano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=LimSoo-Siang
en-aut-sei=Lim
en-aut-mei=Soo-Siang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Zoology and Integrated Microscopy Resource, University of Wisconsin

affil-num=4
en-affil=
kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=National Science Foundation
en-keyword=osteocytes
kn-keyword=osteocytes
en-keyword=osteoblasts
kn-keyword=osteoblasts
en-keyword=gap junctions
kn-keyword=gap junctions
en-keyword=intercellular communication
kn-keyword=intercellular communication
en-keyword=dye coupling
kn-keyword=dye coupling
en-keyword=FRAP
kn-keyword=FRAP
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=2005823
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of the Total Design Method in a survey of Japanese dentists
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Background: This study assessed the application of the Total Design Method (TDM) in a mail survey of Japanese dentists. The TDM was chosen because survey response rates in Japan are
unacceptably low and the TDM had previously been used in a general population survey.<br />
Methods: Four hundred and seventy eight dentist members of the Okayama Medical and Dental Practitioner's Association were surveyed. The nine-page, 27-item questionnaire covered dentist
job satisfaction, physical practice, and dentist and patient characteristics. Respondents to the first mailing or the one-week follow-up postcard were defined as early responders; others who responded were late responders. Responder bias was assessed by examining age, gender and training.<br />
Results: The overall response rate was 46.7% (223/478). The response rates by follow-up mailing were, 18% after the first mailing, 35.4% after the follow-up postcard, 42.3% after the second mailing, and 46.7% after the third mailing. Respondents did not differ from non-respondents in age or gender, nor were there differences between early and late responders.<br />
Conclusion: The application of TDM in this survey of Japanese dentists produced lower rates of response than expected from previous Japanese and US studies.</p>
en-copyright=
kn-copyright=

en-aut-name=NakaiYukie
en-aut-sei=Nakai
en-aut-mei=Yukie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MilgromPeter
en-aut-sei=Milgrom
en-aut-mei=Peter
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshidaToshiko
en-aut-sei=Yoshida
en-aut-mei=Toshiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiharaChikako
en-aut-sei=Ishihara
en-aut-mei=Chikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShimonoTsutomu
en-aut-sei=Shimono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Behavioral Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Dental Public Heath Sciences, University of Washington

affil-num=3
en-affil=
kn-affil=Department of Behavioral Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Behavioral Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Behavioral Pediatric Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
END

start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=6
article-no=
start-page=361
end-page=365
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=200712
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ectopic Varices Rupture in the Gastroduodenal Anastomosis Successfully Treated with N-butyl-2-cyanoacrylate Injection
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>The term &#34;ectopic varices&#34; is used to describe dilated portosystemic collateral veins in unusual locations other than the gastroesophageal region. We recently experienced a rare case of ectopic varices that developed in the gastroduodenal anastomosis after subtotal gastrectomy. A 70-year-old male with liver cirrhosis due to hepatitis C virus infection was admitted for hematemesis and tarry stool. He had received a subtotal gastrectomy with the Billroth-I method for gastric ulcer at 46 years of age. Although emergency endoscopy revealed esophageal and gastric fundal varices, there were no obvious bleeding points. After removal of the coagula, ectopic varices and a fibrin plug were observed on the gastroduodenal anastomosis. During the observation, blood began to spurt from the fibrin plug. N-butyl-2-cyanoacrylate with lipiodol injection succeeded in hemostasis. Splenic angiography showed gastric varices feeding from a short gastric vein and the posterior gastric vein. The blood flow around the bleeding point, as indicated by lipiodol deposition, had decreased, and no feeding vein was observed. Endoscopic and angiographic findings are shown and the treatment for such lesions is discussed.</p>
en-copyright=
kn-copyright=

en-aut-name=OnozatoYasuhiro
en-aut-sei=Onozato
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KakizakiSatoru
en-aut-sei=Kakizaki
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IizukaHaruhisa
en-aut-sei=Iizuka
en-aut-mei=Haruhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MoriKazuyo
en-aut-sei=Mori
en-aut-mei=Kazuyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakizawaDaichi
en-aut-sei=Takizawa
en-aut-mei=Daichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OhyamaTatsuya
en-aut-sei=Ohyama
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ArakawaKazuhisa
en-aut-sei=Arakawa
en-aut-mei=Kazuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AraiHirotaka
en-aut-sei=Arai
en-aut-mei=Hirotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IshiharaHiroshi
en-aut-sei=Ishihara
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=AbeTakehiko
en-aut-sei=Abe
en-aut-mei=Takehiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SoharaNaondo
en-aut-sei=Sohara
en-aut-mei=Naondo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SatoKen
en-aut-sei=Sato
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TakagiHitoshi
en-aut-sei=Takagi
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=MoriMasatomo
en-aut-sei=Mori
en-aut-mei=Masatomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=
kn-affil=Maebashi Red Cross Hospital

affil-num=2
en-affil=
kn-affil=Gunma University

affil-num=3
en-affil=
kn-affil=Maebashi Red Cross Hospital

affil-num=4
en-affil=
kn-affil=Maebashi Red Cross Hospital

affil-num=5
en-affil=
kn-affil=Maebashi Red Cross Hospital

affil-num=6
en-affil=
kn-affil=Maebashi Red Cross Hospital

affil-num=7
en-affil=
kn-affil=Maebashi Red Cross Hospital

affil-num=8
en-affil=
kn-affil=Maebashi Red Cross Hospital

affil-num=9
en-affil=
kn-affil=Maebashi Red Cross Hospital

affil-num=10
en-affil=
kn-affil=Maebashi Red Cross Hospital

affil-num=11
en-affil=
kn-affil=Gunma University

affil-num=12
en-affil=
kn-affil=Gunma University

affil-num=13
en-affil=
kn-affil=Gunma University

affil-num=14
en-affil=
kn-affil=Gunma University
en-keyword=ectopic varices
kn-keyword=ectopic varices
en-keyword=N-butyl-2-cyanoacrylate (Histoacryl)
kn-keyword=N-butyl-2-cyanoacrylate (Histoacryl)
en-keyword=gastroduodenal anastomosis
kn-keyword=gastroduodenal anastomosis
en-keyword=portal hypertension
kn-keyword=portal hypertension
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=2
article-no=
start-page=233
end-page=248
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1934
dt-pub=193409
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Uber die Latentzeit der passiven Anaphylaxie bei Kaninchen.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaTadayuki
en-aut-sei=Ishihara
en-aut-mei=Tadayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=4
article-no=
start-page=461
end-page=467
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1938
dt-pub=193810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Die Zitrikodehydrase und die Gallensaure.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>1. Die Zitrikodehydrasewirkung von verschiedenen Organen wurde vergleichend untersucht. Unter den untersuchten Organen : Leber, Milz, Muskel, Niere und Hoden, ist die Leber in der Wirkung am starksten. 2. Die Zitrikodehydradewirkung der Leber au&#946;ert sich am starksten bei einer H'-Konzentration von pH 8.2. In saurem Medium tritt im Gegensatz zu der Behauptung von Langecker die Spaltung starker zuruck, als in alkalischem, stimmt aber mit der von Reichel und Neeff uberein. 3. Die Wirkung der Gallensaure auf das Zitrikodehydrasesystem der Leber wurde studiert. Gallensaure wirkt auf die Zitronensaurespaltung stark hemmend ein. Die Hemmung tritt bei pH 8.2 am starksten hervor, also gerade bei der optimalen H'-Ionenkonzentration fur die Fermentwirkung. Die Menge der zugesetzten Cholsaure ist nicht von bedeutendem Einflu&#946;, soweit der pH-Wert von 8.2 abweicht. 4. Azetondikarbonsaure wird durch Leberbrei nicht angegriffen. Dieses Resultat stimmt mit dem von Langecker vollig uberein. Der Zitratabbau beim fermentativen Vorgang kann also nicht uber Azetondikarbonsaure vor sich gehen.</p>

en-copyright=
kn-copyright=

en-aut-name=IshiharaTokuharu
en-aut-sei=Ishihara
en-aut-mei=Tokuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=4
article-no=
start-page=545
end-page=554
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1938
dt-pub=193810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Uber den Einfluβ der Gallensaure auf die Glykogenie aus verschiedenen Zuckerderivaten.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaT.
en-aut-sei=Ishihara
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KimuraT.
en-aut-sei=Kimura
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyaziS.
en-aut-sei=Miyazi
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShintakuT.
en-aut-sei=Shintaku
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SugiyamaG.
en-aut-sei=Sugiyama
en-aut-mei=G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Okayama University

affil-num=5
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=4
article-no=
start-page=538
end-page=541
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1938
dt-pub=193810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Beitrage zur Kenntnis der Vogelgalle. Die Galle der Wildente (Mareca penelope), der Hausente (Anas domestica) und des Truthahns (Meleagris gallopavo).
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaTokuharu
en-aut-sei=Ishihara
en-aut-mei=Tokuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MoriTanenao
en-aut-sei=Mori
en-aut-mei=Tanenao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=4
article-no=
start-page=535
end-page=537
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1938
dt-pub=193810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Beitrag zur Kenntnis der Fischgalle. Die Galle des ,,Ako"-Fisches (Sebastodes Matsubarae, Hilgendorf).
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaTokuharu
en-aut-sei=Ishihara
en-aut-mei=Tokuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=1
article-no=
start-page=67
end-page=71
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Japanese guideline for management of cervical spondylotis myelopathy
kn-title=頚椎症性脊髄症の診療ガイドライン
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TanakaMasato
en-aut-sei=Tanaka
en-aut-mei=Masato
kn-aut-name=田中雅人
kn-aut-sei=田中
kn-aut-mei=雅人
aut-affil-num=1
ORCID=

en-aut-name=SugimotoYoshihisa
en-aut-sei=Sugimoto
en-aut-mei=Yoshihisa
kn-aut-name=杉本佳久
kn-aut-sei=杉本
kn-aut-mei=佳久
aut-affil-num=2
ORCID=

en-aut-name=MisawaHaruo
en-aut-sei=Misawa
en-aut-mei=Haruo
kn-aut-name=三澤治夫
kn-aut-sei=三澤
kn-aut-mei=治夫
aut-affil-num=3
ORCID=

en-aut-name=TakahataTomohiro
en-aut-sei=Takahata
en-aut-mei=Tomohiro
kn-aut-name=高畑智宏
kn-aut-sei=高畑
kn-aut-mei=智宏
aut-affil-num=4
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=尾�ｱ敏文
kn-aut-sei=尾�ｱ
kn-aut-mei=敏文
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　整形外科学
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=7
article-no=
start-page=T105
end-page=T111
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930705
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Determination of anionic surfactants in an aqueous medium by differential photometric titration method
kn-title=微分光度滴定法による水溶液での陰イオン界面活性剤の定量
en-subtitle=
kn-subtitle=
en-abstract=A simple and rapid automatic photometric titration method was developed for the determination of anionic surfactants in a one-phase aqueous system with tetrabromophenolphthalein ethyl ester (TBPE) as an indicator. In the presence of non-ionic surfactants such as Triton X-100, protonated TBPE reacts with cation (Q(+)) to form an ion associate (Q(+)?TBPE(-)), causing a color change from yellow to blue. The titrant, distearyldimethylammonium ion, was added to an anionic surfactant solution at pH 3.2, and the absorbance changes were monitored by a fiber-optic sensor with a 630 nm interference filter. The end points were read from the inflection points with differential curves. Anionic surfactants at concentrations from 10(-6)10(-3) mol dm(-3) could be determined by the proposed method. The relative standard deviations of various anionic surfactants were 0.30.4%. The proposed method was applied to some practical samples, and the results, except for those of anionic surfactants possessing polyoxyethylenyl groups, were in good agreement with the results of the JIS titration method (Epton method) and a solvent extraction method with Ethyl Violet.
kn-abstract=微分光度滴定装置を用いて,水溶液での陰イオン界面活性剤を定量する方法について検討した.滴定終点決定の指示薬系としては,酸性染料のテトラブロモフェノールフタレインエチルエステル(TBPE)と非イオン界面活性剤のTriton X-100(TX-100)の混合溶液を用いた.TBPEは非イオン界面活性剤の存在下で,酸性では黄色となり可溶化しているが,滴定剤の第四級アンモニウムイオンと反応するとイオン会合体を形成し,解離型(TBPE-)の青色(λ(max)=610nm)となる.滴定剤には第四級アンモニウム塩のジステアリルジメチルアンモニウム・クロリド(DSDMA(+)・Cl(-))を用いた.本滴定法で10(-6)〜10(-3)Mの濃度範囲の陰イオン界面活性剤が定量できる.実際試料の定量結果はオキシエチレン基を持つもの以外の試料において,JIS滴定法(JIS K 3362)及びエチルバイオレット抽出吸光光度法(JIS K 0101)とよく一致した.
en-copyright=
kn-copyright=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=1
ORCID=

en-aut-name=GaoYunhua
en-aut-sei=Gao
en-aut-mei=Yunhua
kn-aut-name=高雲華
kn-aut-sei=高
kn-aut-mei=雲華
aut-affil-num=2
ORCID=

en-aut-name=IshiharaShinsuke
en-aut-sei=Ishihara
en-aut-mei=Shinsuke
kn-aut-name=石原進介
kn-aut-sei=石原
kn-aut-mei=進介
aut-affil-num=3
ORCID=

en-aut-name=UemuraKouji
en-aut-sei=Uemura
en-aut-mei=Kouji
kn-aut-name=上村幸次
kn-aut-sei=上村
kn-aut-mei=幸次
aut-affil-num=4
ORCID=

en-aut-name=DaitoKazuyuki
en-aut-sei=Daito
en-aut-mei=Kazuyuki
kn-aut-name=大藤和幸
kn-aut-sei=大藤
kn-aut-mei=和幸
aut-affil-num=5
ORCID=

en-aut-name=WakisakaTatsushi
en-aut-sei=Wakisaka
en-aut-mei=Tatsushi
kn-aut-name=脇阪達司
kn-aut-sei=脇阪
kn-aut-mei=達司
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=京都電子工業(株)

affil-num=4
en-affil=
kn-affil=京都電子工業(株)

affil-num=5
en-affil=
kn-affil=花王(株)素材研究所

affil-num=6
en-affil=
kn-affil=花王(株)素材研究所
en-keyword=determination of anionic surfactants
kn-keyword=determination of anionic surfactants
en-keyword=photometric titration
kn-keyword=photometric titration
en-keyword=aqueous medium
kn-keyword=aqueous medium
en-keyword=distearyldimethylammonium ion
kn-keyword=distearyldimethylammonium ion
en-keyword=tetrabromophenolphthalein ethyl ester
kn-keyword=tetrabromophenolphthalein ethyl ester
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=7
article-no=
start-page=593
end-page=598
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970705
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Automatic determination of ionic surfactants in an aqueous medium by a photometric titration method
kn-title=光度滴定法による水溶液でのイオン性界面活性剤の自動定量
en-subtitle=
kn-subtitle=
en-abstract=微分光度滴定法を用いて,水溶液でのイオン性界面活性剤の自動分析システムの構築について検討した.滴定終点決定の指示薬であるテトラブロモフェノールフタレインエチルエステル(TBPE)は界面活性剤との共存系では経時的に分解するため滴定直前に自動添加すること,及び陽イオン界面活性剤は逆滴定法の採用により自動化システムを構築し,同一条件下で陰イオン及び陽イオン界面活性剤の自動連続定量(10分/件)が可能となった.本滴定法で10(-6)〜10(-3)Mの濃度範囲の陰イオン及び陽イオン界面活性剤が定量でき,再現性は0.2〜0.3%と良好であった.各種実際試料について応用した結果,陰イオン界面活性剤において,一部の親水性の高い活性剤(オキシエチレン基を特に多数含む活性剤)以外はJIS法(Epton法)と非常に良い一致を示し,又陽イオン界面活性剤においても,JIS法とほぼ一致した.
kn-abstract=A fully automatic photometric titration method was developed for the determination of anionic and cationic surfactants in a one-phase aqueous system with tetrabromophenolphthalein ethyl ester (TBPE) used as an indicator. To avoid decomposition of the TBPE indicator in the presence of an anionic surfactant in acidic solutions, the buffer and indicator solutions were automatically added to sample solutions just before titration. In an indirect titration method for cationic surfactants, cationic surfactants were automatically determined under the same conditions as in the titration of anionic surfactants. The usual samples were analyzed for less than 10 min at concentrations of 10(-6)10(-3) mol dm(-3). The relative standard deviations of the determination of various surfactants were 0.20.3%. The proposed method was applied to many practical samples. The results, except for those for anionic surfactants possessing polyoxyethylenyl groups and several cationic surfactants, were in good agreement with the results obtained by the JIS titration method (Epton method).
en-copyright=
kn-copyright=

en-aut-name=DaitoKazuyuki
en-aut-sei=Daito
en-aut-mei=Kazuyuki
kn-aut-name=大藤和幸
kn-aut-sei=大藤
kn-aut-mei=和幸
aut-affil-num=1
ORCID=

en-aut-name=WakisakaTatsushi
en-aut-sei=Wakisaka
en-aut-mei=Tatsushi
kn-aut-name=脇阪達司
kn-aut-sei=脇阪
kn-aut-mei=達司
aut-affil-num=2
ORCID=

en-aut-name=IshiharaShinsuke
en-aut-sei=Ishihara
en-aut-mei=Shinsuke
kn-aut-name=石原進介
kn-aut-sei=石原
kn-aut-mei=進介
aut-affil-num=3
ORCID=

en-aut-name=GaoYunhua
en-aut-sei=Gao
en-aut-mei=Yunhua
kn-aut-name=高雲華
kn-aut-sei=高
kn-aut-mei=雲華
aut-affil-num=4
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=花王(株)素材研究所

affil-num=2
en-affil=
kn-affil=花王(株)素材研究所

affil-num=3
en-affil=
kn-affil=京都電子工業 (株) 九州研究所

affil-num=4
en-affil=
kn-affil=岡山大学

affil-num=5
en-affil=
kn-affil=岡山大学
en-keyword=determination of anionic and cationic surfactants, photometric titration
kn-keyword=determination of anionic and cationic surfactants, photometric titration
en-keyword=aqueous medium
kn-keyword=aqueous medium
en-keyword=tetrabromophenolphthalein ethyl ester
kn-keyword=tetrabromophenolphthalein ethyl ester
en-keyword=benzethoniumu
kn-keyword=benzethoniumu
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=10
article-no=
start-page=805
end-page=812
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19971005
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Rapid determination of cationic surfactants in an aqueous medium by the ionassociation titration method coupled with a streaming potential detector
kn-title=流動電位検出/イオン会合滴定法による陽イオン界面活性剤の迅速定量
en-subtitle=
kn-subtitle=
en-abstract=流動電位検出器を用いたイオン会合滴定法による陽イオン界面活性剤の迅速定量法を開発した.本法は, 陽イオン界面活性剤を陰イオン界面活性剤で滴定するもので, 流動電位が正から負に変化することを利用して終点検出を行うものである.検出原理及び装置は非常に簡単なもので, 従来のクロロホルム溶媒を用いない水溶液系で行うことができる.10(-5)〜10(-3)Mの濃度範囲の陽イオン界面活性剤を迅速自動定量 (10分/件) できる.直接滴定法と逆滴定法について検討した結果, 直接滴定法のほうが逆滴定法に比べて再現性の面で優れていることが分かった.陽イオン界面活性剤の各種標準及び実際試料の応用について検討した結果, 分析値はJIS法 (Epton法) と非常に良い一致を示し, 再現性も良好であった.更に, 酸性及びアルカリ性条件下での測定により, アミン塩及び四級アンモニウム塩の分別定量も可能となった.
kn-abstract=An ion-association titration method coupled with a streaming potential detector was developed for the determination of cationic surfactants in a one-phase aqueous system. Dodecyl sulfate ion (LS-) was used as a titrant for cationic surfactants in a direct titration method. LS- was added to a cationic surfactant solution, and a potential change from positive to negative was observed. The end point was read from an inflection point of a differential curve. Direct and indirect titration methods for the determination of cationic surfactants were examined. The direct titration method was better than the in- direct titration method with respect to the precision. The usual samples were titrated within 10 min. Cationic surfactants at concentrations from 10-510-3 mol dm-3 could be determined by the proposed method. Amine and quaternary ammonium salts could be determined under both acidic and alkaline conditions. The proposed method was applied to the determination of various cationic surfactants and cationic surfactants in commercial detergents. The results obtained by the proposed method were in good agreement with those of the JIS titration method (Epton method).
en-copyright=
kn-copyright=

en-aut-name=WakisakaTatsushi
en-aut-sei=Wakisaka
en-aut-mei=Tatsushi
kn-aut-name=脇阪達司
kn-aut-sei=脇阪
kn-aut-mei=達司
aut-affil-num=1
ORCID=

en-aut-name=DaitoKazuyuki
en-aut-sei=Daito
en-aut-mei=Kazuyuki
kn-aut-name=大藤和幸
kn-aut-sei=大藤
kn-aut-mei=和幸
aut-affil-num=2
ORCID=

en-aut-name=IshiharaShinsuke
en-aut-sei=Ishihara
en-aut-mei=Shinsuke
kn-aut-name=石原進介
kn-aut-sei=石原
kn-aut-mei=進介
aut-affil-num=3
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=花王 (株) 素材・プロセス研究所

affil-num=2
en-affil=
kn-affil=花王 (株) 素材・プロセス研究所

affil-num=3
en-affil=
kn-affil=京都電子工業 (株) 九州研究所

affil-num=4
en-affil=
kn-affil=岡山大学
en-keyword=determination of cationic surfactants
kn-keyword=determination of cationic surfactants
en-keyword=ion-association titration
kn-keyword=ion-association titration
en-keyword=aqueous medium
kn-keyword=aqueous medium
en-keyword=streaming potential detector
kn-keyword=streaming potential detector
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=10
article-no=
start-page=763
end-page=770
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19971005
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Rapid determination of anionic surfactants in an aqueous medium by the ionassociation titration method coupled with a streaming potential detector
kn-title=流動電位検出/イオン会合滴定法による陰イオン界面活性剤の迅速定量
en-subtitle=
kn-subtitle=
en-abstract=新しい流動電位検出器を用いたイオン会合滴定法による陰イオン界面活性剤の迅速定量法を開発した.陰イオン界面活性剤を陽イオン界面活性剤で滴定すると, 流動電位が負から正に変化することを用いて終点検出を行うという非常に簡単なもので, 更にクロロホルム溶媒を用いない水溶液系という特徴を有する.測定条件の最適化を行い, 10(-5)〜10(-3)Mの濃度範囲の陰イオン界面活性剤を相対標準偏差0.2〜0.5%と高精度で, 迅速自動定量 (10分/件) できることが分かった.陰イオン界面活性剤の各種標準及び実際試料について応用した結果, 定量値はJIS法 (Epton法) と非常に良い一致を示した.
kn-abstract=An ion-association titration method coupled with a streaming potential detector was developed for the determination of anionic surfactants in a one-phase aqueous system. The titrant, benzethonium chloride (Hyamine) ion, was added to an anionic surfactant solution. The potential then changed from negative to positive along with an increase in the added titrant. The end point was read from an inflection point of a diffrential curve. The usual samples were titrated within 10 min. Anionic surfactants at concentrations from 10(-5)10(-3) mol dm(-3) could be determined by the proposed method. The relative standard deviations of various anionic surfactants were 0.20.6%. The proposed method was applied to the determination of various anionic surfactants and anionic surfactants in commercial detergents. The results obtained for practical samples were in good agreement with those of the JIS titration method (Epton method).
en-copyright=
kn-copyright=

en-aut-name=WakisakaTatsushi
en-aut-sei=Wakisaka
en-aut-mei=Tatsushi
kn-aut-name=脇阪達司
kn-aut-sei=脇阪
kn-aut-mei=達司
aut-affil-num=1
ORCID=

en-aut-name=DaitoKazuyuki
en-aut-sei=Daito
en-aut-mei=Kazuyuki
kn-aut-name=大藤和幸
kn-aut-sei=大藤
kn-aut-mei=和幸
aut-affil-num=2
ORCID=

en-aut-name=IshiharaShinsuke
en-aut-sei=Ishihara
en-aut-mei=Shinsuke
kn-aut-name=石原進介
kn-aut-sei=石原
kn-aut-mei=進介
aut-affil-num=3
ORCID=

en-aut-name=MotomizuShoji
en-aut-sei=Motomizu
en-aut-mei=Shoji
kn-aut-name=本水昌二
kn-aut-sei=本水
kn-aut-mei=昌二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=花王 (株) 素材・プロセス研究所

affil-num=2
en-affil=
kn-affil=花王 (株) 素材・プロセス研究所

affil-num=3
en-affil=
kn-affil=京都電子工業 (株) 九州研究所

affil-num=4
en-affil=
kn-affil=岡山大学
en-keyword=determination of anionic surfactants
kn-keyword=determination of anionic surfactants
en-keyword=ion association titration
kn-keyword=ion association titration
en-keyword=aqueous medium
kn-keyword=aqueous medium
en-keyword=streaming potential detector
kn-keyword=streaming potential detector
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=94
end-page=98
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=PLS-based approach for Kansei analysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A residential garden contributes to mental health in modern life. Gardening is a common recreational activity. From the view of the Kansei engineering, designing the garden is a quite difficult subject. Since garden components such as stones and trees are widely diversified, then number of possible design elements becomes quite large. Meanwhile, evaluation samples that can be used for Kansei Evaluation are limited. Relations between Kansei word evaluation and design elements had been analyzed with Quantification Theory type I, which is a
variation of a multiple regression model. Since QT1 is based on the least square method, number of evaluation samples should be larger than the number of design elements. Thus, QT1 is not applicable in this case. Recently, PLS (Partial Least Squares) is becoming popular in the field of Chemometrics, which deal with extremely large number and interacted predictor variables. In this study, we utilized PLS for analyzing Kansei evaluation on residential gardens and their 89 design elements. Analyzing results of PLS and QT1 are compared. QT1 analyses were done on 5-fold design elements. Even when incorporating 89 variables, PLS's multiple correlation coefficient was much higher than QT1. Analyzing result was made into hand-made virtual reality Kansei engineering system. The system contains two projectors and a PC. 3D models of parts such as trees and stones are dynamically chosen and allocated in the scene. The system was based on originally developed 3D computation and rendering library on Java.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=MatsubaraTatsuro
kn-aut-sei=Matsubara
kn-aut-mei=Tatsuro
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=MatsubaraYukihiro
kn-aut-sei=Matsubara
kn-aut-mei=Yukihiro
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaShigekazu
kn-aut-sei=Ishihara
kn-aut-mei=Shigekazu
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NagamachiMitsuo
kn-aut-sei=Nagamachi
kn-aut-mei=Mitsuo
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Hiroshima City University

affil-num=2
en-affil=
kn-affil=Hiroshima City University

affil-num=3
en-affil=
kn-affil=Hiroshima International University

affil-num=4
en-affil=
kn-affil=Hiroshima International University
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=5-2
article-no=
start-page=2671
end-page=2684
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590425
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A study on the Infectious Hepatitis Virus, Particulary on Its Serologic Characters
kn-title=精製肝炎ウイルスに関する研究殊に血清学的性状に就ての検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author purified the infectious hepatitis virus by the ultra-centrifugation, and studied its serologic characters. The results are briefly summarized as follows: 1) A high titer immune serum could be obtained by many times immunization with the purified virus; the complement fixation index was I; 640 to I: 1280 both in Ishihara and Ogawa strains. 2) The complement fixation reaction with the purified virus gave good results to the convalescent sera diagnosed as acute infectious hepatitis, but the reaction to the sera of the Chronic type of infectious hepatitis was not definite. 3) These results of the complement fixation test can be considered the clear evidence that the isolated virus is the one from the patients of infectious hepatitis. 4) In the neutralization test or Absaettigungsversuch with the serum immunized by the purified virus, a significant result can be obtained with the serum of high complement fixation titer. With the serum of low complement fixation titer, however, the result was often equivocal; the performance of this reaction should be very careful.
en-copyright=
kn-copyright=

en-aut-name=AsakiKozo
en-aut-sei=Asaki
en-aut-mei=Kozo
kn-aut-name=浅木幸三
kn-aut-sei=浅木
kn-aut-mei=幸三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=4-2
article-no=
start-page=1785
end-page=1792
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590405
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Lighting by Fluorescent Lamp The Influence of the moving colored objects upon near point
kn-title=螢光灯による人工照明―各種色彩の移動視標が眼近点距離に及ぼす影響―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fluorescent lamp was compared with incadescent lamp concerning the influence upon the shift of the near point after the task seeing the rotating objects with colored stripes. The apparatus is shown in Fig. 1. The drum is covered by paper with stripes of white and one of the standard colors is used by Japanese Color Institution (black, red, yellow and green). Each stripe has the width of 3 cm and an angle of 45° to its moving direction. It rotates at the speed of 60 times per minute. Each examinee has to see this object through a window of 4×5cm opened in the midst of black carton paper, from the distance of 30cm for 20minutes. During the examination he is requested to number the stripes in order to fix his attention to this visual activity. Examinees were men and women of 19-33 years old, with normal vision and without any ophthalmological defect. Mazda Daylight Fluorescent Lamp (FI-200, 20 watt) and Mazda Gas-filled Lamp (100 volt, 100 watt) were used for the examination. The near point optometer by Dr. Ishihara was used for the measurement of near point. The results were as follows: 1) In the illumination of 200 lux, the near point shifts much further in fluorescent lighting than in incadescent lighting. This is true in every color. 2) In fluorescent lighting black and red are more effective than yellow and green. In incadescent lighting no distinguishable difference can be seen among the colors. 3) The examinee feels more comfortable by the case of incadescent lighting than fluorescent lighting. Yellow is the best and green follows in his subjective feeling. From the above results, the authors conclude that incadescent lighting is better than fluorescent lighting when we are engaged in works to see moving objects.
en-copyright=
kn-copyright=

en-aut-name=MochizukiYoshio
en-aut-sei=Mochizuki
en-aut-mei=Yoshio
kn-aut-name=望月義夫
kn-aut-sei=望月
kn-aut-mei=義夫
aut-affil-num=1
ORCID=

en-aut-name=NasuShozo
en-aut-sei=Nasu
en-aut-mei=Shozo
kn-aut-name=那須昭三
kn-aut-sei=那須
kn-aut-mei=昭三
aut-affil-num=2
ORCID=

en-aut-name=KurodaTakeshi
en-aut-sei=Kuroda
en-aut-mei=Takeshi
kn-aut-name=黒田健
kn-aut-sei=黒田
kn-aut-mei=健
aut-affil-num=3
ORCID=

en-aut-name=OkahiraKazuma
en-aut-sei=Okahira
en-aut-mei=Kazuma
kn-aut-name=岡平和磨
kn-aut-sei=岡平
kn-aut-mei=和磨
aut-affil-num=4
ORCID=

en-aut-name=MurakamiSadao
en-aut-sei=Murakami
en-aut-mei=Sadao
kn-aut-name=村上貞夫
kn-aut-sei=村上
kn-aut-mei=貞夫
aut-affil-num=5
ORCID=

en-aut-name=HigashiwaraRyoei
en-aut-sei=Higashiwara
en-aut-mei=Ryoei
kn-aut-name=東原良頴
kn-aut-sei=東原
kn-aut-mei=良頴
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部衛生学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部衛生学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部衛生学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部衛生学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部衛生学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=1-3
article-no=
start-page=55
end-page=75
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19630330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Histochemical Study on the Effect of the Antitumor Agents in Animal Tumor. Part �V The Hydrolytic and Oxydative Enzymes in the Ehrlich Solid Carcinoma and NF Sarcoma
kn-title=動物腫瘍の蛋白基，各種酵素およびこれに及ぼす制癌剤の影響に関する組織化学的研究 第3編 Ehrlich固型癌，NF肉腫の各種水解酵素，脱水素酵素およびこれに及ぼす制癌剤の影響に関する組織化学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Activities of various kinds of hydrolytic and oxydative enzymes in the Ehrlich solid carcinoma and NF sarcoma were histochemically examined. And the influences of the antitumor agents, i.e. Colchicine, Nitromin, Mitomicin C, Endoxan and Merphyrin on these tumor tissues were also observed, and the following results were obtained. 1. The hydrolytic enzymes: The activities of alkaline-phosphatase and acid-phosphatase in both tumors were negative. The activities of β-Esterase and β-glucuronidase were slightly positive in the proliferating area of tissue, while their activities increased in the degenerated area. Aminopeptidase showed stronger activity in the NF sarcoma than in the Ehrlich solid carcinoma, but its activity decreased promptly if the tumor cells degenerated. 2. The oxydative enzymes: Succinic, lactic and α-glycero-phosphate dehydrogenase showed moderate activities in the proliferating area of tissue, while their activities decreased, gradually in the area of necrobiosis or necrosis. The activities of malic, glutamic and β-hydroxybutyric dehydrogenase were slightly positive in the proliferating area of tissue, and they increased at the transitional part between the proliferating and necrobiosis area. The activity of glucose-6-phosphate dehydrogenase was negative in the NF sarcoma, but moderately positive in the proliferating area of Ehrlich solid carcinoma. When the tumor cells degenerated, its activity was promptly decreased. 3. The degeneration and necrosis of the tumor cell were observed in various degree by the administration of the antitumor agents. The enzyme activities did not show the special changes by the administration of the antitumor agents. The giant cells were observed in the administration of Endoxan, Nitromin and Merphyrin. The giant cells showed the highly increased activities in β-glucuronidase and all oxydative enzymes.
en-copyright=
kn-copyright=

en-aut-name=IshiharaKiyoshi
en-aut-sei=Ishihara
en-aut-mei=Kiyoshi
kn-aut-name=石原清
kn-aut-sei=石原
kn-aut-mei=清
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=1-3
article-no=
start-page=41
end-page=54
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19630330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Histochemical Study on the Effect of the Antitumor Agents in Animal Tumor. Part �U The Protein and Protein-Bound Amino-Bases in the Ehrlich Solid Carcinoma and NF Sarcoma
kn-title=動物腫瘍の蛋白基,各種酵素およびこれに及ぼす制癌剤の影響に関する組織化学的研究 第2編 固型腫瘍の蛋白基およびこれに及ぼす制癌剤の影響に関する組織化学研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The protein and protein-bound amino-bases in the Ehrlich solid carcinoma and NF sarcoma were histochemically examined. And the influences of the antitumor agents, i.e. Colchicine, Nitromin, Sarcomycin, Mitomycin C, Endoxan and Merphyrin on these tissues were also observed, and the following results were obtained. 1. The stainability of the protein-bound SH and SH-SS was slightly increased by the administration of the antitumor agent. Both tumors showed moderate reaction in the proliferating area of tissue, while they showed always moderate or high reactions in the area of necrobiosis or degeneration, and especially remarkable by the administration of Mitomycin C and Sarcomycin. 2. The protein-bound SS reaction did not reveal so remarkable changes by antitumor agents in both tumors, but was moderately increased by Colchicine administration. 3. The tyrosine reaction did not show the definite regularities in both tumors by the administration of the antitumor agent. 4. The protein-bound NH(2) reaction did not show the definite regularities in both tumors by the administration of the antitumor agent. Especially, the reaction in the proliferating area of the NF sarcoma was moderately increased by the administration of Sarcomycin and Mitomycin C. 5. The phenol and its compounds reaction did not show the remarkable changes in both tumors by the administration of the antitumor agents.
en-copyright=
kn-copyright=

en-aut-name=IshiharaKiyoshi
en-aut-sei=Ishihara
en-aut-mei=Kiyoshi
kn-aut-name=石原清
kn-aut-sei=石原
kn-aut-mei=清
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=1-3
article-no=
start-page=25
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19630330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Histochemical Study on the Effect of the Antitumor Agent in Animal Tumor. Part �T The Protein and Protein-Bound Amino-Base in Ascites Tumor Cell
kn-title=動物腫瘍の蛋白基，各種酵素およびこれに及ぼす制癌剤の影響に関する組織化学的研究 第1編 腹水腫瘍細胞の蛋白基およびこれに及ぼす制癌剤の影響に関する細胞化学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The protein and protein-bound amino-bases in the Ehrlich and Yoshida tumor cells were cytochemically examined. And the influences of the antitumor agents, i. e. Colchicine, Nitromin, Sarcomycin and Mitomycin C on these tumor cells were also observed, and the following results were obtained. 1. The protein-bound SH showed the moderate reaction in cytoplasma and nucleus in both tumors. The nucleolus of the Ehrlich tumor cell showed a weak reaction, while that of the Yoshida tumor cell a remarkably positive reaction. By Colchicine administration, the stainability of SH was increased. 2. The protein-bound SH-SS reactions revealed almost the same localisation in both tumors as the SH reaction, but the intensity of the reaction was stronger than that of SH. And the cytochemical pattern of SH-SS caused by the antitumor agents was almost the same as SH. 3. The protein-bound SS reaction was weak in both tumor cells. Generally, SS reaction diminished by the administration of the antitumor agents, especially by MitomycinC administration to the Yoshida tumor, Nitromin and large amount of Colchicine to the Ehrlich tumor cells. Only by MitomycinC administration to the Ehrlich ascites tumor, the reaction of SH was increased. 4. In the Yoshida tumor, by the administration of all antitumor agents, the stainability of SH, SH-SS and SS were diminished, while in the Ehrlich tumor the changes of the stainability were variable. 5. Tyrosine reaction was moderate in both tumor cells. The nucleus of the Ehrlich tumor showed the negative, and that of Yoshida tumor the slightly positive reaction. 6. The NH(2) reaction was moderate in the cytoplasma of both tumors, and very strong in the nucleus. In the Yoshida tumor, the stainability was diminished by the administration of all antitumor agents, while in the Ehrlich tumor the reaction was diminished by the large amount of Colchicine, and the reaction was elevated by Nitromin and small dosis of Colchicine. 7. The phenol and its compound reaction were moderate in the Ehrlich tumor and weak in the Yoshida tumor. By the administration of the antitumor agent, these reactions were generally diminished in both tumor cells, but Mitomycin C administration to the Ehrlich tumor these reactions were elevated.
en-copyright=
kn-copyright=

en-aut-name=IshiharaKiyoshi
en-aut-sei=Ishihara
en-aut-mei=Kiyoshi
kn-aut-name=石原清
kn-aut-sei=石原
kn-aut-mei=清
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=80
cd-vols=
no-issue=1-2
article-no=
start-page=211
end-page=222
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1968
dt-pub=19680228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on the Development of Gastric Ulcer Following Adrenalectomy and Hypophysectomy in Rat
kn-title=副腎剔出後及び脳下垂体剔出後の胃潰瘍発生に関する実験的研究 第2編 �T 副腎・下垂体剔出後の電解質及び血糖の変化と胃潰瘍に関する実験的研究�U 走神経切断術の胃潰瘍発生におよぼす影響に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I. Serum Electrolytes and Blood Glucose in the Development of Gastric Ulcer Following Adrenalectomy Bilateral adrenalectomy in rats caused increase in potassium and decrease in sodium in serum and also decrease in blood glucose level, and resulted in development of ulcer on the gastric mucous membrane. When the above unbalance was corrected with either the oral administration of 1% sodium chloride solution or intramuscular administration of cortisone (0.05 to 0.1 mg., per 100 gm. of body weight, per day), the development of the ulcer was prevented. However, administration of higher dose of cortisone alone (5 mg. per day, per rat) did not prevent the ulcer formation, resulting in hypernatremia, hypopotassemia and hyperglycemia. The prevention was obtained by additional oral administration of 1% potassium chloride solution. In summary, these results are highly indicative of the presence of some direct or indirect relationship between the unbalanced serum electrolytes and blood glucose level due to adrenal deficiency and the deterioration in the local resistance of gastric mucosa against the digestive process to develop subsequent ulceration. Association of vagal nerve in the mechanism of this type of gastric ulcerogenesis was also demonstrated.
en-copyright=
kn-copyright=

en-aut-name=IshiharaHiromichi
en-aut-sei=Ishihara
en-aut-mei=Hiromichi
kn-aut-name=石原弘道
kn-aut-sei=石原
kn-aut-mei=弘道
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=80
cd-vols=
no-issue=1-2
article-no=
start-page=197
end-page=209
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1968
dt-pub=19680228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental Studies on the Development of Gastric Ulcer Following Adrenalectomy and Hypophysectomy in Rat
kn-title=副腎別出後及び脳下垂体別出後の胃潰瘍発生に関する実験的研究 第1編 副腎剔出後の電解質及び血糖の変化と胃潰瘍の関係
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I. Serum Electrolytes and Blood Glucose in the Development of Gastric Ulcer Following Adrenalectomy Bilateral adrenalectomy in rats caused increase in potassium and decrease in sodium in serum and also decrease in blood glucose level, and resulted in development of ulcer on the gastric mucous membrane. When the above unbalance was corrected with either the oral administration of 1% sodium chloride solution or intramuscular administration of cortisone (0.05 to 0.1 mg., per 100 gm. of body weight, per day), the development of the ulcer was prevented. However, administration of higher dose of cortisone alone (5 mg. per day, per rat) did not prevent the ulcer formation, resulting in hypernatremia, hypopotassemia and hyperglycemia. The prevention was obtained by additional oral administration of 1% potassium chloride solution. In summary, these results are highly indicative of the presence of some direct or indirect relationship between the unbalanced serum electrolytes and blood glucose level due to adrenal deficiency and the deterioration in the local resistance of gastric mucosa against the digestive process to develop subsequent ulceration.
en-copyright=
kn-copyright=

en-aut-name=IshiharaHiromichi
en-aut-sei=Ishihara
en-aut-mei=Hiromichi
kn-aut-name=石原弘道
kn-aut-sei=石原
kn-aut-mei=弘道
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=1-2
article-no=
start-page=107
end-page=112
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1986
dt-pub=19860228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Duplicate foreign bodies in the airway and gastrointestinal tract: Report of a case
kn-title=気道・食道に分離した重複異物症例 ―教室異物統計と文献的考察―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A case of having two or more foreign bodies simultaneously in the airway and gastrointestinal tract is rare. The authors reported a case of two foreign bodies. A 54-year-old man who carelessly swallowed thumbtacks visited our clinic. An X-ray examination revealed thumbstack in the right bronchus and another in the stomach. The former was removed with a ventilation bronchoscope, and the latter was excreted spontaneously 2 days later. The authors have experienced 84 cases of esophageal foreign bodies and 47 cases of tracheobroncheal ones in the last 10 years. Cases of foreign bodies in both locations showed a higher frequency in males, and the majority of the cases were of children 3 years old or less. Coins were the most common esophageal foreign body, and peanuts were most common tracheobroncheal foreign body.The most frequent location of the foreign bodies was the cervical constriction in cases of esophageal foreign bodies, being twice as frequent as the right bronchus. Two cases of multiple foreign bodies have been treated in our clinic, and both of them were of 2 coins in the upper esophagus.
en-copyright=
kn-copyright=

en-aut-name=SuehiroMichio
en-aut-sei=Suehiro
en-aut-mei=Michio
kn-aut-name=末広倫雄
kn-aut-sei=末広
kn-aut-mei=倫雄
aut-affil-num=1
ORCID=

en-aut-name=UedaSetsuo
en-aut-sei=Ueda
en-aut-mei=Setsuo
kn-aut-name=上田節夫
kn-aut-sei=上田
kn-aut-mei=節夫
aut-affil-num=2
ORCID=

en-aut-name=IshiharaMotomasa
en-aut-sei=Ishihara
en-aut-mei=Motomasa
kn-aut-name=石原基正
kn-aut-sei=石原
kn-aut-mei=基正
aut-affil-num=3
ORCID=

en-aut-name=TomotsuTakao
en-aut-sei=Tomotsu
en-aut-mei=Takao
kn-aut-name=鞆津尚夫
kn-aut-sei=鞆津
kn-aut-mei=尚夫
aut-affil-num=4
ORCID=

en-aut-name=OkamotoHiroshi
en-aut-sei=Okamoto
en-aut-mei=Hiroshi
kn-aut-name=岡本宏司
kn-aut-sei=岡本
kn-aut-mei=宏司
aut-affil-num=5
ORCID=

en-aut-name=TasakaShuji
en-aut-sei=Tasaka
en-aut-mei=Shuji
kn-aut-name=田坂周治
kn-aut-sei=田坂
kn-aut-mei=周治
aut-affil-num=6
ORCID=

en-aut-name=TamuraShintaro
en-aut-sei=Tamura
en-aut-mei=Shintaro
kn-aut-name=田村慎一郎
kn-aut-sei=田村
kn-aut-mei=慎一郎
aut-affil-num=7
ORCID=

en-aut-name=NanbaMasayuki
en-aut-sei=Nanba
en-aut-mei=Masayuki
kn-aut-name=難波正行
kn-aut-sei=難波
kn-aut-mei=正行
aut-affil-num=8
ORCID=

en-aut-name=MasudaYu
en-aut-sei=Masuda
en-aut-mei=Yu
kn-aut-name=増田游
kn-aut-sei=増田
kn-aut-mei=游
aut-affil-num=9
ORCID=

en-aut-name=OguraYoshio
en-aut-sei=Ogura
en-aut-mei=Yoshio
kn-aut-name=小倉義郎
kn-aut-sei=小倉
kn-aut-mei=義郎
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室

affil-num=2
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室

affil-num=3
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室

affil-num=4
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室

affil-num=5
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室

affil-num=6
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室

affil-num=7
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室

affil-num=8
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室

affil-num=9
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室

affil-num=10
en-affil=
kn-affil=岡山大学耳鼻咽喉科学教室
en-keyword=気道
kn-keyword=気道
en-keyword=食道
kn-keyword=食道
en-keyword=重複異物
kn-keyword=重複異物
en-keyword=異物統計
kn-keyword=異物統計
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=15
end-page=28
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19791201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Iron Losses of Silicon Steel due to Rotating Fluxes (Inclined Rotating Flux and Distorted One)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Characteristics of iron losses in silicon steel due to inclined rotating fluxes and distorted ones are described. Iron losses due to rotating fluxes have been measured at various conditions for grain-oriented and non-oriented silicon steels by using an improved thermistor-bridge method. Loss measurements indicate that the iron loss due to the inclined rotating flux is greater than that due to the non-inclined one. However, the iron loss due to the distorted rotating flux is not always greater than that due to the non-distorted one.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TakahashiNorio
kn-aut-sei=Takahashi
kn-aut-mei=Norio
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=2
article-no=
start-page=55
end-page=61
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=19760127
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A New Application of Transient Recorder to Magnetic Measurements (Part I: Core Loss Measurement at Very Low Frequencies)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A new method have been developed based upon analogue-to-digital conversion techniques and memories. The method involves the scaling of operating frequency from "real" to "optimum" for the power loss measurement. The advantages of using this techniques are as follows: (1) extreme availability at lower frequency region, (2) high accuracy and high stability, (3) simple measuring procedure, (4) digital indication. This method can be measured the power losses over the frequency range 0.1Hz to 1kHz for magnetic circuit and d.c. to 1kHz in such a purely resistive circuit. We estimate the accuracy of this core loss measuring system within 1.0% over all these frequency range. Using this system, specific core losses of the various grades of silicon iron have been measured in the frequency range 0.1Hz to 200Hz.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakataTakayoshi
kn-aut-sei=Nakata
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=MatsubaraKazunori
kn-aut-sei=Matsubara
kn-aut-mei=Kazunori
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakanoMasanori
kn-aut-sei=Nakano
kn-aut-mei=Masanori
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=3
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=4
en-affil=
kn-affil=Department of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=2
article-no=
start-page=47
end-page=51
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1974
dt-pub=19741225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mass Spectral Fragmentations. I. Mass Spectral Date on the Synthetic Intermediates Related to the Preparation of Linaloyl Oxide
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper describes mass spectral data from synthetic
intermediates of linaloyl oxide. The fragmentation of sulfur functional groups including compounds l-8 would provide fruitful evidences for structural assignment of acyclic and alicyclic monoterpenoid precursors. Since, 1,3-dithianyl group in l,2, and 3 can provide a base peak and the elimination of the sulfinyl group from 7 and 8 is considered to occur at the initial stage of the fragmentation.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=ToriiSigeru
kn-aut-sei=Torii
kn-aut-mei=Sigeru
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=UneyamaKenji
kn-aut-sei=Uneyama
kn-aut-mei=Kenji
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaMasakazu
kn-aut-sei=Ishihara
kn-aut-mei=Masakazu
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Industrial Chemistry

affil-num=2
en-affil=
kn-affil=Department of Industrial Chemistry

affil-num=3
en-affil=
kn-affil=Department of Industrial Chemistry
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1973
dt-pub=19730720
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Experimental Studies of Various Factors Affecting Minor Loop Hysteresis Loss
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=When the distorted flux is induced in a magnetic circuit, the minor loops arise sometimes inside the major hysteresis loop. The area, accordingly the hysteresis loss of the minor loop,is affected by its amplitude and position, by the maximum flux density, by the quality of material, etc.. In this paper, we describe the experimental studies of the factors on the minor loop hysteresis loss. A method of getting the displacement factor of a minor loop which is placed at arbitrary position and has any amplitude is developed from our experimental results. Using this method, the core losses caused by the distorted flux can be calcuLated within the error less than three percent, even if the amplitude of the minor loop becomes near to the amplitude of the major loop.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakataTakayoshi
kn-aut-sei=Nakata
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakanoMasanori
kn-aut-sei=Nakano
kn-aut-mei=Masanori
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=3
en-affil=
kn-affil=Department of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=2
article-no=
start-page=89
end-page=100
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19721013
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis on Magnetic Characteristics of Three-Phase Core-Type Transformers [Part II: Non-Linear Solutions and Experimental Results for R3-Type Core]
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper deals with the magnetic characteristics (the flux distributions, core losses, etc.) of threephase core-type transformers with double-layer. In the preceding report, only linear solutions have been given. In this paper, also non-linear solutions are discussed. Therefore, the flux waves of each magnetic path are distorted and contain various harmonics. When core losses are calculated, the hysteresis losses of minor loops are taken account. The results of analysis are compared with those of experiments. It is concluded that the principal cause for increasing core losses of this type core is the eddy current loss produced by harmonic fluxes. The flux distributions and the core losses depend on the shapes of the magnetization curve and the core-loss curve, that is, on the quality of the materials.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakataTakayoshi
kn-aut-sei=Nakata
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=MorimotoHideki
kn-aut-sei=Morimoto
kn-aut-mei=Hideki
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=3
en-affil=
kn-affil=Department of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=2
article-no=
start-page=85
end-page=88
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19721013
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A New Representation of Distorted Wave Forms
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A new method for representing distorted wave forms is investigated. The method suggested by us is a modified vector symbolic method. It has been hitherto thought that the vector symbolic method cannot be applied to the distorted waves, because the rotating speeds of each harmonic vector are not identical. Representing the argument of the n-th harmonic vector by l/n times as large as the phase angle of the harmonic component, the relative positions of respective harmonic vectors are invariable wherever the standard vector is put, and the wave shape can be deduced from the vector diagram. We found various correspondences between the wave forms and the vector diagrams. Therefore, the wave shape can be estimated from the vector diagram, and the mutual relationships between two wave forms can also be known. In electric or magnetic circuits, the causes of distorted wave forms are in general obvious. Therefore, there are very often the fixed relationships between the amplitudes and phase angles of the harmonics. Further, in polyphase a.c. circuits, there are often the fixed relationships between corresponding harmonics in the wave forms of the respective phases. When the wave forms of those circuits are discussed, the new method investigated in this paper may offer a useful key.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakataTakayoshi
kn-aut-sei=Nakata
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=1
article-no=
start-page=67
end-page=82
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1971
dt-pub=19710901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis on Magnetic Characteristics of Three-Phase Core-Type Transformers (Part I: Fundamental Equations and Linear Solutions)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, we report the procedure to analyse magnetic circuits and give the linear solutions on magnetic characteristics of the three-phase core-type transformer which is composed of the complicated magnetic paths. First, we explain the construction of cores investigated and normalize the sizes of a core. To analyse these magnetic circuits, we introduced the electrical eqcuivalent circuits and obtained the general fundamental equations for each core. Then, we drew the linear-numerical solutions using an electronic computer, and cleared the relationships between the sizes of a core and the amplitudes and phase angles of fluxes in magnetic paths. Related with the above facts, we investigate the influence of these sizes on the core loss using cores of various quality.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakataTakayoshi
kn-aut-sei=Nakata
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=1
article-no=
start-page=127
end-page=130
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1968
dt-pub=19680901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Contactless Vectormeter Using Thyristors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to measure the iron loss of the silicon steel plates, we produced a vectormeter using a thyristor and a gate turn off thyristor by way of experiment. This equipment is very useful, because the frequency range is
improved very much in comparison with the vectormeter which is composed of the mechanical rectifying system using a synchronous motor, namely, is enlarged from 60Hz to 1kHz,
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakataTakayoshi
kn-aut-sei=Nakata
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Depertment of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Depertment of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=1
article-no=
start-page=111
end-page=119
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1967
dt-pub=19670401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Convenient Design-Method of Pressure Tank Used for Oil-Immersed Transformer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, the easy design-method of trasformer tank is described. Using nomographs induced here, the bending moments on the oval tank or round cornered rectangular tank which is used for usual transformer, are briefly calculated. And the relation between the type of transformer and the distribution of bending moment is cleared. Using these results, even electric engineer who has poor knowledge for strength of materials, can easily design a most suitable tank.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakataTakayoshi
kn-aut-sei=Nakata
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=1
article-no=
start-page=70
end-page=77
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1966
dt-pub=19660331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Calculation of Circuit Constants for Impulse Voltage Generator by Means of Computer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, we describe the way to compute circuit constants of the impulse voltage generator by means of the digital computer, when an impulse voltage waveform is given. The definition of waveform is to be revised, and this definition is adopted to our computation. From the results, we can see the influence of revising definition upon circuit constants. We also devised graphs, from which we can easily determine the L-C-R circuit constants. (see Fig.2(a))
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NakataTakayoshi
kn-aut-sei=Nakata
kn-aut-mei=Takayoshi
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYoshiyuki
kn-aut-sei=Ishihara
kn-aut-mei=Yoshiyuki
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=MoriyasuTadataka
kn-aut-sei=Moriyasu
kn-aut-mei=Tadataka
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=2
en-affil=
kn-affil=Department of Electrical Engineering

affil-num=3
en-affil=
kn-affil=Mizushima Technical High School
END

start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=2
article-no=
start-page=33
end-page=44
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=19890330
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Flow of Rarefied Vapour past a Liquid Sphere
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper deals with the low Mach numbers flow of a rarefied vapour past a liquid sphere accompanied with condensation and evaporation at its surface. The linearized Bhatnager-Gross-Krook(B-G-K} equation is used for the analysis, and from it the integral equations of the density, temperature and flow velocities are derived. These integral equations are solved numerically over a wide range of the Knudsen number covering from the slip flow to the nearly free molecular flow. The drag on the sphere is also calculated and is compared with that of previous work.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IshiharaYuji
kn-aut-sei=Ishihara
kn-aut-mei=Yuji
aut-affil-num=1
ORCID=

en-aut-name=YamamotoKyoji
en-aut-sei=Yamamoto
en-aut-mei=Kyoji
kn-aut-name=山本恭二
kn-aut-sei=山本
kn-aut-mei=恭二
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Engineering Mathematics

affil-num=2
en-affil=
kn-affil=Engineering Mathematics
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=7-8
article-no=
start-page=721
end-page=733
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the mechanism and treatment of intractable asthma Part 1. Effects of a specific thromboxane A(2) synthetase inhibitor in lymphocyte and neutrophil functions in intractable asthmatics
kn-title=難治性喘息の病態と治療に関する研究　第1編　難治性喘息患者のリンパ球および好中球機能に及ぼす選択的 Thromboxane A(2) 合成酵素阻害剤の効果
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify whether thromboxane A(2) (TXA(2)) is involved in type III and IV allergy, so-called "cell-mediated allergy", the effects of a specific TXA(2) synthetase inhibitor, sodium ozagrel (OKY-046) on peripheral blood mononuclear cells and neutrophils in adult intractable asthmatics were studied. Lymphocyte blastogenesis and interleukin-2 (IL-2) production from peripheral blood mononuclear cells stimulated by PHA and Candida antigen in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. The neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor (ECF) from peripheral blood nomonuclear cells stimulated by Candida antigen in intractable asthmatics tended to be suppressed by OKY-046. Furthermore, leukotriene C(4) (LTC(4)) and superoxide (O(2)(-)) production from peripheral blood neutrophils in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. These findings suggest that TXA(2) plays an important role in the development of intractable asthma and OKY-046, which has a suppressive effect on type IV allergy caused by lymphocyte activation and on mediator release from neutrophils, might be a useful drug in the treatment of intractalbe asthmatics.
en-copyright=
kn-copyright=

en-aut-name=KanehiroArihiko
en-aut-sei=Kanehiro
en-aut-mei=Arihiko
kn-aut-name=金廣有彦
kn-aut-sei=金廣
kn-aut-mei=有彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Intractable asthma
kn-keyword=Intractable asthma
en-keyword=cell-mediated allergy
kn-keyword=cell-mediated allergy
en-keyword=thromboxane A(2)
kn-keyword=thromboxane A(2)
en-keyword=thromboxane A(2) synthetase inhibitor (OKY-046)
kn-keyword=thromboxane A(2) synthetase inhibitor (OKY-046)
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=5-6
article-no=
start-page=641
end-page=647
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Differrential diagnosis of thyrotoxicosis using inhibition assay of a protein present in thyroid follicular spaces
kn-title=甲状腺由来可溶性蛋白の測定による甲状腺中毒症の鑑別について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The difference between stimulative and destructive thyrotoxicosis is usually identified by thyroidal uptake of radioactive iodine, but uptake is not always available. At present, there is no reliable in vitro method of differential diagnosis of thyrotoxicosis. We conducted an investigation of an in vitro method of differential diagnosis of thyrotoxicosis by inhibition assay using monoclonal antibodies that recognized an antigen (14kD) differing from thyroglobulin and thyroid peroxidase. The antigen is the soluble material present in the thyroid follicular space, and is detected by immunofluorescent study. We measured the concentration of this antigen in the sera of patients with thyroid diseases by inhibition assay. In sera from patients with destructive thyrotoxicosis, the concentration of the antigen was lower than that in sera from normal subjects and from Graves' disease patients. There was no significant difference between normal subjects and Graves' disease patients. The data suggest that measurement of the antigen in sera from patients with thyroid disease can be useful for the differential diagnosis of thyrotoxicosis.
en-copyright=
kn-copyright=

en-aut-name=YamaharaShigehiro
en-aut-sei=Yamahara
en-aut-mei=Shigehiro
kn-aut-name=山原茂裕
kn-aut-sei=山原
kn-aut-mei=茂裕
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第三内科学教室
en-keyword=甲状腺中毒症
kn-keyword=甲状腺中毒症
en-keyword=亜急性甲状腺炎
kn-keyword=亜急性甲状腺炎
en-keyword=バセドウ病
kn-keyword=バセドウ病
en-keyword=モノクローナル抗体
kn-keyword=モノクローナル抗体
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=7-8
article-no=
start-page=241
end-page=252
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hemodynamic and hormonal changes under the biventricular bypass system with ventricular fibrillated hearts
kn-title=心室細動下両心バイパス型人工心臓における循環及び内分泌動態の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hemodynamic and hormonal changes were studied in 13 sheep whose entire circulation was maintained by a biventricular bypass system with a pair of pusher-plate type blood pumps. Ventricular fibrillation was induced and pneumatically driven pumps placed outside the body kept the animals alive for 2-48 days (average: 11 days). Pump output and aortic pressure stayed within physiological ranges, but central venous pressure was elevated from 5 to 10-13 �oHg after surgery. Serum levels of antidiuretic hormone, cortisol and insulin were stabilized soon after surgery. Adrenaline level and renin activity did not change significantly. For unknown reasons, the noradrenaline level showed a temporary increase after a week. Atrial natriuretic peptide (ANP) increased significantly 5 days after surgery. There were significant drops in triiodothyronine (T(3)) and thyroxine (T(4)) levels after surgery with gradual recovery afterward to 40% and 50% of the control levels, respectively. These results suggested that the biventricular bypass system maintained hemodynamic conditions similar to those maintained by the natural heart, although ANP, T(3) and T(4) values were changed.
en-copyright=
kn-copyright=

en-aut-name=NakayamaHironobu
en-aut-sei=Nakayama
en-aut-mei=Hironobu
kn-aut-name=中山裕宣
kn-aut-sei=中山
kn-aut-mei=裕宣
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=左右非同期 variable rate mode
kn-keyword=左右非同期 variable rate mode
en-keyword=両心バイパス型人工心臓
kn-keyword=両心バイパス型人工心臓
en-keyword=甲状腺ホルモン
kn-keyword=甲状腺ホルモン
en-keyword=心房性ナトリウム利尿ペプタイド
kn-keyword=心房性ナトリウム利尿ペプタイド
END

start-ver=1.4
cd-journal=joma
no-vol=116
cd-vols=
no-issue=2
article-no=
start-page=89
end-page=96
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=石灰沈着を伴うび漫性神経原線維変化病における α-Synuclein 陽性病変から分かること―岡山大学医学賞（新見賞）を受賞して―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=横田修
kn-aut-sei=横田
kn-aut-mei=修
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=寺田整司
kn-aut-sei=寺田
kn-aut-mei=整司
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=石津秀樹
kn-aut-sei=石津
kn-aut-mei=秀樹
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=黒田重利
kn-aut-sei=黒田
kn-aut-mei=重利
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　精神神経病態学
en-keyword=α-synuclein
kn-keyword=α-synuclein
en-keyword=diffuse neurofibrillary tangles with calcification
kn-keyword=diffuse neurofibrillary tangles with calcification
en-keyword=NAC
kn-keyword=NAC
en-keyword=synucleinopathy
kn-keyword=synucleinopathy
en-keyword=tauopathy
kn-keyword=tauopathy
END

start-ver=1.4
cd-journal=joma
no-vol=117
cd-vols=
no-issue=2
article-no=
start-page=109
end-page=118
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=誘導性ヒスタミンはＨ(2)受容体刺激を介してP.ances-LPS 誘発性肝炎からマウスを保護する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=横山穣
kn-aut-sei=横山
kn-aut-mei=穣
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科薬理学
en-keyword=内因性ヒスタミン
kn-keyword=内因性ヒスタミン
en-keyword=サイトカイン
kn-keyword=サイトカイン
en-keyword=マウス急性肝炎
kn-keyword=マウス急性肝炎
END

start-ver=1.4
cd-journal=joma
no-vol=118
cd-vols=
no-issue=3
article-no=
start-page=193
end-page=198
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=モデル動物を用いたタウオパシーの病態解明と有効な薬剤同定：αトコフェロールの効果について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=安田華枝
kn-aut-sei=安田
kn-aut-mei=華枝
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=石原武士
kn-aut-sei=石原
kn-aut-mei=武士
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=寺田整司
kn-aut-sei=寺田
kn-aut-mei=整司
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=John Q.Trojanowski
kn-aut-sei=John Q.
kn-aut-mei=Trojanowski
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=Virginia M.-Y.Lee
kn-aut-sei=Virginia M.-Y.
kn-aut-mei=Lee
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=黒田重利
kn-aut-sei=黒田
kn-aut-mei=重利
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=三船病院

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 精神神経病態学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 精神神経病態学

affil-num=4
en-affil=
kn-affil=Center for Neurodegenerative Disease Research,Institute on Aging,University of Pennsylvania

affil-num=5
en-affil=
kn-affil=Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 精神神経病態学
en-keyword=タウオパシー
kn-keyword=タウオパシー
en-keyword=認知症
kn-keyword=認知症
en-keyword=神経変性疾患
kn-keyword=神経変性疾患
en-keyword=酸化ストレス
kn-keyword=酸化ストレス
en-keyword=α トコフェロール
kn-keyword=α トコフェロール
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ニワトリ胚頭蓋骨中骨細胞におけるConnexin 43を介した蛍光色素の細胞間移動はホルモンやpH、カルシウムイオンによって調節を受ける
kn-title=Hormonal, pH, and Calcium Regulation of Connexin 43-Mediated Dye Transfer in Osteocytes in Chick Calvaria.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=石原嘉人
kn-aut-sei=石原
kn-aut-mei=嘉人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=2
article-no=
start-page=85
end-page=90
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20000324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Public transportation and the disabled person
kn-title=身体機能障害者の公共交通機関利用を妨げる要因
en-subtitle=
kn-subtitle=
en-abstract=A survey was distributed by mail to disabled people who received functional training in 1997. Of 208 questionnaires sent, 125 (60.1%) were returned. Sixty-seven (53.6%) of the respondents had experience traveled outside. People who participate in functional trainning for disability hope to have an attendant to accompany them when traveling. One primary factor that hinders traveling outside and using public transportation is that they cannot ask for help because of shyness. Another factor is the construction of entrances (e.g.,bumps) for vehicles which cannot be traversed easily. Reasons differed among those who had traveled outside and those who had not. It is necessary to prepare an environment (e.g., public transportationto) for ease of use for disabled persons in regional communities.
kn-abstract=機能訓練事業として実施している「生活リハビリ教室」の教室生208名を対象に，公共交通機関を利用して外出するために障害になっている要因を明らかにする目的で，郵送法による自記式アンケート調査を行った。回答は125名（60.1％）からあった。外出経験がある者は67名（53.6％）で外出経験がない者が58名であった。外出時に付添いが必要と思っている者は，外出経験のない者に多かった。公共交通機関を利用しての外出を阻害している要因には，乗り物の昇降口に段差があることや早く発車して危険である，また周囲の人に介助を依頼しにくいことなどが挙げられている。身体機能障害者が外出できない理由は個人によって異なってはいるが，地域社会に身体機能障害者を受け入れる環境を整えていく必要がある。
en-copyright=
kn-copyright=

en-aut-name=HigakiMichiyo
en-aut-sei=Higaki
en-aut-mei=Michiyo
kn-aut-name=檜垣みちよ
kn-aut-sei=檜垣
kn-aut-mei=みちよ
aut-affil-num=1
ORCID=

en-aut-name=AkazawaYoshiko
en-aut-sei=Akazawa
en-aut-mei=Yoshiko
kn-aut-name=赤澤良子
kn-aut-sei=赤澤
kn-aut-mei=良子
aut-affil-num=2
ORCID=

en-aut-name=OhtaYasuyo
en-aut-sei=Ohta
en-aut-mei=Yasuyo
kn-aut-name=太田康代
kn-aut-sei=太田
kn-aut-mei=康代
aut-affil-num=3
ORCID=

en-aut-name=AkazawaToyoko
en-aut-sei=Akazawa
en-aut-mei=Toyoko
kn-aut-name=赤澤豊子
kn-aut-sei=赤澤
kn-aut-mei=豊子
aut-affil-num=4
ORCID=

en-aut-name=OhtaHisae
en-aut-sei=Ohta
en-aut-mei=Hisae
kn-aut-name=太田久恵
kn-aut-sei=太田
kn-aut-mei=久恵
aut-affil-num=5
ORCID=

en-aut-name=OhnoNobuko
en-aut-sei=Ohno
en-aut-mei=Nobuko
kn-aut-name=大野伸子
kn-aut-sei=大野
kn-aut-mei=伸子
aut-affil-num=6
ORCID=

en-aut-name=MiyakeHiromi
en-aut-sei=Miyake
en-aut-mei=Hiromi
kn-aut-name=三宅浩美
kn-aut-sei=三宅
kn-aut-mei=浩美
aut-affil-num=7
ORCID=

en-aut-name=IshiharaHiroe
en-aut-sei=Ishihara
en-aut-mei=Hiroe
kn-aut-name=石原寛恵
kn-aut-sei=石原
kn-aut-mei=寛恵
aut-affil-num=8
ORCID=

en-aut-name=MatsuuraNorie
en-aut-sei=Matsuura
en-aut-mei=Norie
kn-aut-name=松浦徳枝
kn-aut-sei=松浦
kn-aut-mei=徳枝
aut-affil-num=9
ORCID=

en-aut-name=AbeKeiko
en-aut-sei=Abe
en-aut-mei=Keiko
kn-aut-name=安部啓子
kn-aut-sei=安部
kn-aut-mei=啓子
aut-affil-num=10
ORCID=

en-aut-name=AkagiMika
en-aut-sei=Akagi
en-aut-mei=Mika
kn-aut-name=赤木美鹿
kn-aut-sei=赤木
kn-aut-mei=美鹿
aut-affil-num=11
ORCID=

en-aut-name=OhtaTakeo
en-aut-sei=Ohta
en-aut-mei=Takeo
kn-aut-name=太田武夫
kn-aut-sei=太田
kn-aut-mei=武夫
aut-affil-num=12
ORCID=

en-aut-name=OkanoHatsue
en-aut-sei=Okano
en-aut-mei=Hatsue
kn-aut-name=岡野初枝
kn-aut-sei=岡野
kn-aut-mei=初枝
aut-affil-num=13
ORCID=

affil-num=1
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=2
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=3
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=4
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=5
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=6
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=7
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=8
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=9
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=10
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=11
en-affil=
kn-affil=倉敷市役所水島支所

affil-num=12
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻

affil-num=13
en-affil=
kn-affil=岡山大学医学部保健学科看護学専攻
en-keyword=身体機能障害者 (disabled person)
kn-keyword=身体機能障害者 (disabled person)
en-keyword=外出 (traveling)
kn-keyword=外出 (traveling)
en-keyword=公共交通機関 (public transportation)
kn-keyword=公共交通機関 (public transportation)
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=1
article-no=
start-page=229
end-page=246
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=199603
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Deregulation and Economic Promotion of Intermount Region
kn-title=規制緩和と中山間地域振興策
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaTerutoshi
en-aut-sei=Ishihara
en-aut-mei=Terutoshi
kn-aut-name=石原照敏
kn-aut-sei=石原
kn-aut-mei=照敏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=1
article-no=
start-page=89
end-page=98
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=2001
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Current Evalution and Problems of Training Practice for School Nurse-Teachers in Okayama University
kn-title=岡山大学における養護実習の現状と課題
en-subtitle=
kn-subtitle=
en-abstract=This study is aimed to consider the problems of training practice for school nurse-teachers by analyzing the research about the current evaluation and effect of the training in Okayama University. In the present situation it is possible to learn fundamental duties such as physical examination and health guidance. However some issues which include cooperation with other teaching staff, participation in management of the school health committee and organizing school health activities are still left to argue.
kn-abstract=本研究では、岡山大学における養護実習の現状とその効果について、実習生及び指導養護教諭に対する調査結果を分析することにより、これからの養護教諭養成における実習のあり方について検討することを目的とした。現状では、健康診断、保健指導、救急処置等の基本的職務については学ぶことができているが、養護教諭の新たな役割とされる健康相談活動については、子どもの心の状態を探る段階にとどまっている。また、学校保健委員会活動等の企画運営への参画など、他の教職員との連携のあり方や学校保健活動、養護活動の進め方について十分に学び得ることは、短期間の実習だけでは困難な事項もある。今後の課題としては、「養護実習が養護教諭養成カリキュラム全体を推し進める要の位置にある」ことを明確にし、関係者が協力して、実習の事前・事後における指導内容・方法の改善を図っていくことが必要である。
en-copyright=
kn-copyright=

en-aut-name=IshiharaMasae
en-aut-sei=Ishihara
en-aut-mei=Masae
kn-aut-name=石原昌江
kn-aut-sei=石原
kn-aut-mei=昌江
aut-affil-num=1
ORCID=

en-aut-name=NomuraRika
en-aut-sei=Nomura
en-aut-mei=Rika
kn-aut-name=野村梨香
kn-aut-sei=野村
kn-aut-mei=梨香
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学
en-keyword=養護実習 (School Nurse-Teacher Training Practicd)
kn-keyword=養護実習 (School Nurse-Teacher Training Practicd)
en-keyword=養護実習生 (School Nurse-Teacher Students)
kn-keyword=養護実習生 (School Nurse-Teacher Students)
en-keyword=実習校 (School for Training Practice)
kn-keyword=実習校 (School for Training Practice)
en-keyword=養成機関 (Training Institutions)
kn-keyword=養成機関 (Training Institutions)
en-keyword=実習評価 (Practicing Evaluation)
kn-keyword=実習評価 (Practicing Evaluation)
END

start-ver=1.4
cd-journal=joma
no-vol=85
cd-vols=
no-issue=1
article-no=
start-page=23
end-page=30
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Callus Formation and Plant Regeneration of Herbs in Perilla Family
kn-title=シソ科ハーブ類のカルス培養および植物体再分化
en-subtitle=
kn-subtitle=
en-abstract=ハーブの新しい植物育成のための細胞融合や遺伝子導入の基礎技術として、カルス培養の方法を検討した。材料として、カルス培養の為に、8品種のバジルおよび6種類のシソ科ハーブを用いて実験した。得られた結果は次の様であった。1:植物ホルモンの効果　カルスは、無菌実生の胚軸および子葉をMS培地に0.1mg/?の2,4-DとBAを添加した培地で培養することにより効果的に形成され、また同じ組成の培地または3mg/? 2,4-Dと0.1mg/? BA添加培地継代することにより高い増殖率を示したが、植物体は再分化しなかった。植物体の再分化は上記の材料を0.1mg/?　のNAAと0.1または1.0mg/?のBAを添加した培地で培養することにより、カルスおよび不定根または不定芽を再分化することができたが、カルス形成は2,4-D添加培地に及ばさなかった。培地添加サイトカイニンとしては、カルス形成のためには2ipが大きなカルスを形成したが、植物体の再分化のためにはBAしか効果がなかった。2:植え付け外植体の差　無菌培養した実生の発芽1から3週間後の胚軸を外植体とした時、カルス形成には大きな差は見られなかった。無菌実生の1週間後の胚軸、根、子葉を外植体とした時、子葉が最も重いカルス形成し、次いて胚軸であった。3:8品種のバジルのカルス形成と不定芽再生2,4-Dと2ip添加培地でカルスの形成が最もよかったのはレタスバジルで次いでアニスバジル、レモンバジル、プッシュバジル、スイートバジル、パープルラフレスバジル、ダークオパールバジル、シナモンバジルの順で、レタスバジルはシナモンバジルの3.3倍の重さがあった。NAAとBA添加培地では、カルスはいずれの品種でも形成されたが、不定芽が再生されたのはスイートバジル、ダークオパールバジル、ブッシュバジルであった。4:6種のシソ科ハーブのカルス形成いずれの種類もカルスは形成されたが、スイートバジルに比較して生体重は軽く、アカジソがかろうじて匹敵するくらいで、アオジソ、レモンバーム、ペパーミント、スイートマジョラムの順に軽くなり、特にスイートマジョラムは形成外植体率も低かった。　
kn-abstract=Effective methods of callus culture of herbs were studied to establish basic techniques for cell fusion and gene engineering. Eight basil cultivars, five species of Perilla family and a sweet basil were used, and following results were obtained. 1: Effects of phytohormones on callus formation. Callus formed effectively from hypocotyls and cotyledons of sterile seedlings cultured on MS medium supplemented with 0.1mg/12,4-D and BA. Plantlets succeeded in regenerating from callus cultured on MS medium supplemented with 0.1mg/I NAA and BA, but callus formation on a similar medium was inferior to that on MS medium supplemented with 2,4-D and BA. Callus formed best on MS medium supplemented with 2ip, among other cytokinins, but only BA actually induced regeneration of plantlets from callus. 2: Effects of age and different organs of explants on callus formation. Callus with similar weight formed from hypocotyls of young seedlings about 1-3 weeks after germination. The heaviest callus formed from cotyledons, followed by hypocotyls and roots. 3: Callus formation and regeneration of adventitious buds in eight basil cultivars. Calli formed cotyledons of lettuce basil, Anise basil, lemon basil, bush basil, sweet basil, purple raffles basil, dasil opal basil and cinnamon basil, in descending orderof weight, on MS medium supplemented with 2,4-D and 2ip. Callus from lettuce basil was three times as heavy as that from cinnamon basil. Callus formed on MS medium supplemented NAA and BA from cotyledone of all cultivars, but adventitious buds regenerated only from sweet basil, dark opal basil and bush basil. 4: Callus formation from six Perilla herbs. Callus fromed from hypocotyls and cotyledons of sweet basil, red perilla, green perilla, lemon balm, peppermint and sweet majoram in descending order of weight.
en-copyright=
kn-copyright=

en-aut-name=MatsubaraSachiko
en-aut-sei=Matsubara
en-aut-mei=Sachiko
kn-aut-name=松原幸子
kn-aut-sei=松原
kn-aut-mei=幸子
aut-affil-num=1
ORCID=

en-aut-name=InoMasato
en-aut-sei=Ino
en-aut-mei=Masato
kn-aut-name=猪雅人
kn-aut-sei=猪
kn-aut-mei=雅人
aut-affil-num=2
ORCID=

en-aut-name=MurakamiKenji
en-aut-sei=Murakami
en-aut-mei=Kenji
kn-aut-name=村上賢治
kn-aut-sei=村上
kn-aut-mei=賢治
aut-affil-num=3
ORCID=

en-aut-name=KamadaMayumi
en-aut-sei=Kamada
en-aut-mei=Mayumi
kn-aut-name=鎌田真由美
kn-aut-sei=鎌田
kn-aut-mei=真由美
aut-affil-num=4
ORCID=

en-aut-name=IshiharaIzumi
en-aut-sei=Ishihara
en-aut-mei=Izumi
kn-aut-name=石原泉
kn-aut-sei=石原
kn-aut-mei=泉
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学

affil-num=5
en-affil=
kn-affil=岡山大学
en-keyword=callus culture
kn-keyword=callus culture
en-keyword=plant regeneration
kn-keyword=plant regeneration
en-keyword=Perilla family
kn-keyword=Perilla family
en-keyword=phytohormone
kn-keyword=phytohormone
en-keyword=sweet basil
kn-keyword=sweet basil
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=加齢による視覚機能の変化と日常生活への影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaKeiko
en-aut-sei=Ishihara
en-aut-mei=Keiko
kn-aut-name=石原恵子
kn-aut-sei=石原
kn-aut-mei=恵子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19950325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=パン酵母無細胞抽出液を用いる高効率不斉還元
kn-title=Highly Efficient Asymmetric Reduction by Use of Bakers' Yeast Cell-Free Extract
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaKohji
en-aut-sei=Ishihara
en-aut-mei=Kohji
kn-aut-name=石原浩二
kn-aut-sei=石原
kn-aut-mei=浩二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=1
article-no=
start-page=19
end-page=26
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1988
dt-pub=1988
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Production and Vegetative Propagation of Virus Free Plants in Dioscorea sp.
kn-title=ヤマノイモのウイルス・フリー株の育成と栄養繁殖
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=ヤマノイモのウイルスフリー株を育成し,さらに能率よく増殖するため,茎頂,茎切片,葉切片培養を試みた.基本培地はMS(1962)にしょ糖3%,寒天0.8%とさらに種々の濃度のNAAとBAを添加した.ナガイモ,ツクネイモのむかごによる増殖も試み,以下の結果を得た. (1)ヤマノイモの茎項0.2-0.3�oを0.01mg/l NAAとBA添加基本培地に植付けると小植物体を再生できた.又0.1mg/lの両ホルモン添加培地上で2月間培養するとカルスが形成され,基本培地に移植することにより小植物体が再生した.株分けによる増殖率は8か月間で6.3倍であった. (2)無菌植物の茎,葉切片をNAA0.1mg/l,BA0.01mg/l添加培地に植付けることにより,いずれの器官からも2.4%の不定芽形成,9%の発根がみられた. (3)ナガイモの根を10cmに切断し,10,30,50cmの深さの畑土に植付け,むかご形成をみたところ,50,10,30cm区の順に821球,654球,458球のむかご着生がみられた. (4)ツクネイモのつるに4処理,(a)対照,(b)下垂づるの摘心および摘花,(c)摘葉,(d)葉えき部のアルミホイルによる遮光,をしてむかごの着生をみた.処理開始2月後に着生つる率とつるあたりむかご数を調査したところ,(a)50%,11球,(b)74%,71球,(c)100%, 40球,(d)73%,39球,と摘葉区で最もむかごの着生数が多かった.しかしつるあたりのむかご重量は遮光区(d)が最も重かった。
en-copyright=
kn-copyright=

en-aut-name=MatsubaraSachiko
en-aut-sei=Matsubara
en-aut-mei=Sachiko
kn-aut-name=松原幸子
kn-aut-sei=松原
kn-aut-mei=幸子
aut-affil-num=1
ORCID=

en-aut-name=IshiharaMasatoshi
en-aut-sei=Ishihara
en-aut-mei=Masatoshi
kn-aut-name=石原正利
kn-aut-sei=石原
kn-aut-mei=正利
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=兵庫県豊岡農業改良普及所
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=1
article-no=
start-page=16
end-page=25
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1952
dt-pub=1952
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Effect of Calcium on Chestnut. : I. On the Telerance for Calcium in Water Culture. (1)
kn-title=栗に及ぼす石灰の影響 I.水耕栽培に於ける石灰抵抗性に就て(第1報)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=(1)栗の石灰抵抗性を検する為にN,P,K,Mg及Fe各々を35,23,29,20及5ppmを含む培養液にCaOl2にてCaを0,25,100,400,800,1600ppm礫耕のみを加へたものを用ひて礫耕及水耕栽培を行つた.(2)主として花崗岩よりなる礫を用ひた礫耕に於てI区(pH4.0-5.0),II区(pH5.5-6.0)III区(pH6.8-7.0)の各々につき石灰濃度1-5区(即ち0,25,100,400,1600ppm)とを組合せた15の区を設けて栗を栽培したところ次の傾向を認めた.(a)栗の生育はI>II>III区の順に良好である.(b)石灰の高濃度に堪へる程度もI>II>III区の順に大である.(C)82日間の栽培にて培養液中にCa0ppmにても正常な生育を認めた.(3)水耕栽増にて栗,桃及梨の実生を72日間,又少し後れて夏橙及柿を夫々81日及51日間栽培した.是等の試験にては培養液のpH値は5.5とし,Ca濃度はI,II,III,IV区各々25, 100,400,800ppmとした.栗の生育はI,II両区の間に統計的に差が認められなかつたが,IV区及III区の栗は実験開始後各々5及7週間後殆ど枯死した.CaCl2を用ひた培養液に於ける石灰抵抗性は栗<桃<夏橙<梨<柿の順に大である. (4)CaCl2を用ひたCa400ppmを含む培養液中にはCl 708ppmが附随する.この為に栗の葉にClによる被害を生じたことを確認した.夏橙及桃もClに対して抵抗性が小であることを推定出来る.(5)栗な極めて軽度の所謂石灰嫌忌性を有するものと思はれる.栗の石灰嫌忌性に就て二三考察するところがあつた。
en-copyright=
kn-copyright=

en-aut-name=HondaN.
en-aut-sei=Honda
en-aut-mei=N.
kn-aut-name=本多昇
kn-aut-sei=本多
kn-aut-mei=昇
aut-affil-num=1
ORCID=

en-aut-name=HayashiK.
en-aut-sei=Hayashi
en-aut-mei=K.
kn-aut-name=林清史
kn-aut-sei=林
kn-aut-mei=清史
aut-affil-num=2
ORCID=

en-aut-name=OkazakiM.
en-aut-sei=Okazaki
en-aut-mei=M.
kn-aut-name=岡崎光良
kn-aut-sei=岡崎
kn-aut-mei=光良
aut-affil-num=3
ORCID=

en-aut-name=IshiharaS.
en-aut-sei=Ishihara
en-aut-mei=S.
kn-aut-name=石原三郎
kn-aut-sei=石原
kn-aut-mei=三郎
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
END