result 159 件
| FullText URL | K0005110 abstract_review.pdf K0005110_fulltext.pdf |
|---|---|
| Author | Ueda, Yuki| |
| Published Date | 2015-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5110号 |
| Granted Date | 2015-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Author | Mizuki, Yutaka| Takaki, Manabu| Okahisa, Yuko| Sakamoto, Shinji| Kodama, Masafumi| Ujike, Hiroshi| Uchitomi, Yosuke| |
|---|---|
| Published Date | 2014-11 |
| Publication Title | Human Psychopharmacology: Clinical and Experimental |
| Volume | volume29 |
| Issue | issue6 |
| Content Type | Journal Article |
| FullText URL | K0005070_abstract_review.pdf K0005070_fulltext.pdf |
|---|---|
| Author | Tsuzaki, Ryuichiro| |
| Published Date | 2014-12-31 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5070号 |
| Granted Date | 2014-12-31 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| JaLCDOI | 10.18926/AMO/53122 |
|---|---|
| FullText URL | 69_1_51.pdf |
| Author | Mu Mu Shwe| Kyi Kyi Nyunt| Okada, Shigeru| Harano, Teruo| Hlaing Myat Thu| Hla Myat Mo Mo| Mo Mo Win| Khin Khin Oo| KhinThet Wai| Khin Saw Aye| Myo Khin| |
| Abstract | Persistent infection with oncogenic types of human papillomavirus (HPV) is the most important risk factor associated with cervical cancer. This study detected the oncogenic HPV genotypes in cervical neoplasia in relation to clinicopathological findings using a cross-sectional descriptive method in 2011 and 2012. Cervical swabs and colposcopy-directed cervical biopsy tissues were collected from 108 women (median age 45 years;range 20-78) showing cervical cytological changes at Sanpya General Hospital, Yangon, Myanmar. HPV DNA testing and genotyping were performed by polymerase chain reaction and restriction fragment length polymorphism. HPV was identified in women with cervical intraepithelial neoplasia (CIN) 1 (44.4%), CIN2 (63.2%), CIN3 (70.6%), and squamous cell carcinoma (SCC) (74.1%). The association between cervical neoplasia and HPV positivity was highly significant (p＝0.008). Most patients infected with HPV were between 40-49 years of age, and the youngest were in the 20- to 29-year-old age group. The most common genotype was HPV 16 (65.6%) with the following distribution:70% in CIN1, 41.7% in CIN2, 91.7% in CIN3, and 60% in SCC. HPV-31 was the second-most frequent (21.9%):30% in CIN1, 33.3% in CIN2, 8.3% in CIN3, and 15% in SCC. The third-most frequent-genotype was HPV-18 (7.8%):8.3% in CIN1, and 20% in SCC. Another genotype was HPV-58 (4.7%):16.7% in CIN1 and 5% in SCC. The majority of CIN/SCC cases were associated with HPV genotypes 16, 31, 18, and 58. If oncogenic HPV genotypes are positive, the possibility of cervical neoplasia can be predicted. Knowledge of the HPV genotypes distribution can predict the effectiveness of the currently used HPV vaccine. |
| Keywords | human papillomavirus genotyping Myanmar |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-02 |
| Volume | volume69 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 51 |
| End Page | 58 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25703171 |
| Web of Science KeyUT | 000349740300006 |
| Author | Mizoo, Taeko| Taira, Naruto| Nishiyama, Keiko| Nogami, Tomohiro| Iwamoto, Takayuki| Motoki, Takayuki| Shien, Tadahiko| Matsuoka, Junji| Doihara, Hiroyoshi| Ishihara, Setsuko| Kawai, Hiroshi| Kawasaki, Kensuke| Ishibe, Youichi| Ogasawara, Yutaka| Komoike, Yoshifumi| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2013-12-01 |
| Publication Title | BMC Cancer |
| Volume | volume13 |
| Content Type | Journal Article |
| Author | Takeuchi, Yasuto| Ikeda, Fusao| Moritou, Yuki| Hagihara, Hiroaki| Yasunaka, Tetsuya| Kuwaki, Kenji| Miyake, Yasuhiro| Ohnishi, Hideki| Nakamura, Shinichiro| Shiraha, Hidenori| Takaki, Akinobu| Iwasaki, Yoshiaki| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2013-03 |
| Publication Title | Journal of Gastroenterology |
| Volume | volume48 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Moritou, Yuki| Ikeda, Fusao| Takeuchi, Yasuto| Seki, Hiroyuki| Nanba, Shintaro| Iwasaki, Yoshiaki| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2014-02 |
| Publication Title | Journal of Clinical Microbiology |
| Volume | volume52 |
| Issue | issue2 |
| Content Type | Journal Article |
| Title Alternative | The 2013 Incentive Award of the Okayama Medical Association in General Medical Science (2013 Yuuki Prize) |
|---|---|
| FullText URL | 126_187.pdf |
| Author | Yamamoto, Hiromasa| |
| Abstract | 受賞対象論文: Yamamoto H, Higasa K, Sakaguchi M, Shien K, Soh J, Ichimura K, Furukawa M, Hashida S, Tsukuda K, Takigawa N, Matsuo K, Kiura K, Miyoshi S, Matsuda F, Toyooka S：Novel germline mutation in the transmembrane domain of HER2 in familial lung adenocarcinomas. J Natl Cancer Inst (2014) 106, djt338 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-12-01 |
| Volume | volume126 |
| Issue | issue3 |
| Start Page | 187 |
| End Page | 190 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.187 |
| NAID | 130004903235 |
| JaLCDOI | 10.18926/AMO/52898 |
|---|---|
| FullText URL | 68_5_291.pdf |
| Author | Tsuzaki, Ryuichiro| Takaki, Akinobu| Yagi, Takahito| Ikeda, Fusao| Koike, Kazuko| Iwasaki, Yoshiaki| Shiraha, Hidenori| Miyake, Yasuhiro| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Nobuoka, Daisuke| Utsumi, Masashi| Nakayama, Eiichi| Fujiwara, Toshiyoshi| Yamamoto, Kazuhide| |
| Abstract | It is not known how the immune system targets hepatitis C virus (HCV)-infected HLA-mismatched hepatocytes under immune-suppressed conditions after orthotopic liver transplantation (OLT). In addition, the relationship between the HCV-specific immune response and IL28B variants as predictors of HCV clearance has not been well-characterized. We determined the IL28B polymorphisms for 57 post-OLT HCV carriers, and we assessed the HCV-specific immune responses by measuring the peripheral blood mononuclear cell-derived HCV-specific interferon-gamma (IFN-γ) response using an enzyme-linked immunospot assay. At 1-3 years after OLT, patients with no active hepatitis showed higher total spots on the immunospot assay. At＞3 years after OLT, patients with resolved HCV showed higher levels of core, NS3, NS5A, and total spots compared to the chronic hepatitis patients. The IL28B major genotype in the donors correlated with higher spot counts for NS5A and NS5B proteins at 1-3 years after OLT. In the post-OLT setting, the HCV-specific immune response could be strongly induced in patients with no active hepatitis with an IL28B major donor or sustained virological response. Strong immune responses in the patients with no active hepatitis could only be maintained for 3 years and diminished later. It may be beneficial to administer IFN treatment starting 3 years after OLT, to induce the maximum immunological effect. |
| Keywords | interferon gamma ELISPOT assay single nucleotide polymorphisms dendritic cell CD4 T cell |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-10 |
| Volume | volume68 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 291 |
| End Page | 302 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25338486 |
| Web of Science KeyUT | 000343269300006 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53129 |
| Author | Monden, Yuki| Takasaki, Kazuto| Futo, Satoshi| Niwa, Kousuke| Kawase, Mitsuo| Akitake, Hiroto| Tahara, Makoto| |
|---|---|
| Published Date | 2014-09-20 |
| Publication Title | Journal of Biotechnology |
| Volume | volume185 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52790 |
|---|---|
| FullText URL | 68_4_243.pdf |
| Author | Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Nishina, Sohji| Korenaga, Masaaki| Hino, Keisuke| Fujioka, Shin-ichi| Osawa, Toshiya| Itoshima, Tatsuya| Kawanaka, Miwa| Yamada, Gotaro| Kariyama, Kazuya| Takayama, Hiroki| Kubota, Junichi| Morimoto, Yoichi| Mizushima, Takaaki| Yamashita, Haruhiko| Tanioka, Hiroaki| Negoro, Yuji| Toshimori, Junichi| Kobashi, Haruhiko| Hirano, Atsushi| Itano, Yasuo| Takaki, Akinobu| Yamamoto, Kazuhide| |
| Abstract | Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p＜0.01), among men who had sex with men (100%, p＜0.005), and among patients having sex with unspecified partners (44.8%, p＜0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A. |
| Keywords | acute hepatitis hepatitis B virus |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 247 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145410 |
| Web of Science KeyUT | 000340687500006 |
| JaLCDOI | 10.18926/AMO/52404 |
|---|---|
| FullText URL | 68_2_79.pdf |
| Author | Mu-Mu-Shwe| Harano, Teruo| Okada, Shigeru| Aye-Aye-Win| Khin-Saw-Aye| Hlaing-Myat-Thu| Mo-Mo-Win| Khin-Khin-Oo| Myo-Khin| |
| Abstract | This study aimed to determine the prevalence of normal and abnormal cervical cytology in women who attended the cervical cancer screening clinic of the Department of Medical Research in Lower Myanmar, and to determine the proportion of high-risk (HR) human papillomavirus (HPV) infection and HPV genotypes in women with normal and abnormal cervical cytology. A total of 1,771 women were screened from 2010 to 2011. Among them, 762 women (43.0%) had a normal smear, and 866 (48.9%) and 87 (4.9%) were diagnosed with inflammatory smears and atypical squamous cells of undetermined significance (ASCUS), respectively. Diagnoses of low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) numbered 42 (2.3%) and 11 (0.6%) respectively. Three cases of squamous cell carcinoma (SCC) (0.2%) were detected. Cervical swabs were collected from 96 women with abnormal cervical cytology and 20 with normal cytology. HR-HPV DNA testing was performed by polymerase chain reaction (PCR) with pU1M/pU2R primers. HR-HPV were identified in 35.5% (22/62) of inflammatory smears, 60% (6/10) of ASCUS, 86.7% (13/15) of LSIL, 50% (3/6) of HSIL, 100% (3/3) of SCC and 5% (1/20) of normal cytology. In PCR-positive cases, HPV genotyping was analyzed by the cleaved amplification polymorphism method. The most prevalent HPV genotypes were HPV-16 (60.4%) followed by HPV-31 (14.6%), HPV-18 (12.5%) and HPV-58 (12.5%). Women with abnormal cervical cytology were 10 times more likely to be HR-HPV positive than those with normal cytology (p＝0.0001). This study suggests that the implementation of a cervical cytology screening program and routine vaccination against HPV in preadolescent and adolescent groups are needed to reduce the burden of HPV-associated cervical cancer. |
| Keywords | human papillomavirus cervical neoplasia genotyping Myanmar |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 87 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743783 |
| Web of Science KeyUT | 000334652700003 |
| Author | Tatsukawa, Masashi| Takaki, Akinobu| Shiraha, Hidenori| Koike, Kazuko| Iwasaki, Yoshiaki| Kobashi, Haruhiko| Fujioka, Shin-Ichi| Sakaguchi, Kohsaku| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2011-10-21 |
| Publication Title | BMC Cancer |
| Volume | volume11 |
| Content Type | Journal Article |
| Author | Close, Timothy J.| Bhat, Prasanna R.| Lonardi, Stefano| Wu, Yonghui| Rostoks, Nils| Ramsay, Luke| Druka, Arnis| Stein, Nils| Svensson, Jan T.| Wanamaker, Steve| Bozdag, Serdar| Roose, Mikeal L.| Moscou, Matthew J.| Chao, Shiaoman| Varshney, Rajeev K.| Szuecs, Peter| Sato, Kazuhiro| Hayes, Patrick M.| Matthews, David E.| Kleinhofs, Andris| Muehlbauer, Gary J.| DeYoung, Joseph| Marshall, David F.| Madishetty, Kavitha| Fenton, Raymond D.| Condamine, Pascal| Graner, Andreas| Waugh, Robbie| |
|---|---|
| Published Date | 2009-12-04 |
| Publication Title | BMC Genomics |
| Volume | volume10 |
| Content Type | Journal Article |
| Author | Shahinnia, Fahimeh| Sayed-Tabatabaei, Badraldin Ebrahim| Sato, Kazuhiro| Pourkheirandish, Mohammad| Komatsuda, Takao| |
|---|---|
| Published Date | 2009-12 |
| Publication Title | Breeding Science |
| Volume | volume59 |
| Issue | issue4 |
| Content Type | Journal Article |
| FullText URL | O0004411_abstract_review.pdf O0004411_fulltext.pdf |
|---|---|
| Author | Tatsukawa, Masashi| |
| Published Date | 2013-12-31 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第4411号 |
| Granted Date | 2013-12-31 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| JaLCDOI | 10.18926/AMO/52139 |
|---|---|
| FullText URL | 68_1_17.pdf |
| Author | Moritou, Yuki| Ikeda, Fusao| Iwasaki, Yoshiaki| Baba, Nobuyuki| Takaguchi, Kouichi| Senoh, Tomonori| Nagano, Takuya| Takeuchi, Yasuto| Yasunaka, Tetsuya| Ohnishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
| Abstract | The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy. |
| Keywords | hepatic steatosis genetic polymorphism interferon HCV |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 17 |
| End Page | 22 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553484 |
| Web of Science KeyUT | 000331592800003 |
| Author | Yamasaki, Yoshie| |
|---|---|
| Published Date | 2013-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Yasuda, Shozo| |
|---|---|
| Published Date | 1964 |
| Publication Title | Berichte des Ohara Instituts für landwirtschaftliche Biologie, Okayama Universität |
| Volume | volume12 |
| Issue | issue2 |
| Content Type | Departmental Bulletin Paper |
| Author | Teshigawara, Sanae| Wada, Jun| Hida, Kazuyuki| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Iseda, Izumi| Matsushita, Yuichi| Miyatake, Nobuyuki| McDonald, John F.| Hotta, Kikuko| Makino, Hirofumi| |
|---|---|
| Published Date | 2012-07 |
| Publication Title | Journal of Clinical Endocrinology & Metabolism |
| Volume | volume97 |
| Issue | issue7 |
| Content Type | Journal Article |
