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JaLCDOI 10.18926/AMO/62378
FullText URL 75_4_403.pdf
Author Matoba, Ryo| Morizane, Yuki|
Abstract Epiretinal membrane (ERM) is a common retinal disease characterized by cellular proliferation and metaplasia that lead to the formation of a pathological fibrocellular membrane immediately superjacent to the inner retinal surface. The vast majority of ERMs are considered idiopathic. However, ERM formation can result from various primary intraocular diseases, including retinal breaks and detachment, retinal vascular diseases, and vitreoretinal inflammatory conditions. Although ERMs are generally asymptomatic or cause mild metamorphopsia and/or a modest decrease in visual acuity, some can cause severe macular distortion and macular edema, resulting in significantly impaired function. Surgical removal of ERM is the only treatment, and improvements in vitrectomy systems have enabled less invasive treatment. However, there are currently no standardized criteria for ERM surgery, and the indications for surgery are determined from the patient’s subjective symptoms. Another problem with ERM surgery is that not all patients show satisfactory postoperative recovery of visual function. Thus, further research is needed to determine the criteria for ERM surgery and methods to improve the postoperative prognosis.
Keywords epiretinal membrane vitrectomy optical coherence tomography internal limiting membrane lamellar macular hole
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2021-08
Volume volume75
Issue issue4
Publisher Okayama University Medical School
Start Page 403
End Page 413
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34511606
Web of Science KeyUT 000697944600001
NAID 120007146059
FullText URL fulltext20210726-1.pdf
Author Liu, Shihui| Matsuo, Toshihiko| Miyaji, Mary| Hosoya, Osamu|
Keywords NK-4 retina apoptosis RNA-seq photoreceptor retinitis pigmentosa antioxidant metabolism
Published Date 2021-7-19
Publication Title Pharmaceuticals
Volume volume14
Issue issue7
Publisher MDPI AG
Start Page 694
ISSN 1424-8247
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
File Version publisher
DOI 10.3390/ph14070694
Related Url isVersionOf https://doi.org/10.3390/ph14070694
FullText URL fulltext20210625-1.pdf
Author Matsuo, Toshihiko| Tanaka, Takehiro| Nakamura, Aya| Wada, Koichiro|
Keywords prostate cancer choroidal/uveal tumor choroidal/uveal metastasis radiation surgical castration complete remission hormonal therapy literature review prostate-specific antigen PSA positron emission tomography PET
Published Date 2021-06-23
Publication Title Journal of Investigative Medicine High Impact Case Reports
Volume volume8
Publisher American Federation for Medical Research
Start Page 1
End Page 8
ISSN 2324-7096
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 American Federation for Medical Research
File Version publisher
PubMed ID 34159819
DOI 10.1177/23247096211026471
NAID 120007089816
Related Url isVersionOf https://doi.org/10.1177/23247096211026471
JaLCDOI 10.18926/AMO/62236
FullText URL 75_3_391.pdf
Author Fujiwara, Miyuki| Kimura, Shuhei| Morizane Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Kanzaki, Yuki | Morizane, Yuki|
Abstract A 58-year-old Japanese man underwent vitrectomy for rhegmatogenous retinal detachment (RRD) in 2002. Twelve years later, optical coherence tomography revealed the development of a lamellar macular hole; the visual acuity was 20/200. Two years later, because metamorphopsia and the foveal retina thinning were aggravated, epiretinal proliferation embedding was performed to restore the foveal structure by transplanting glial cells to the foveal cavity. The patient was followed-up for 4 years, and his macular morphology and visual acuity (20/66) improved. No complications occurred. This appears to be the first report of epiretinal proliferation embedding for a lamellar macular hole post-RRD repair.
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-06
Volume volume75
Issue issue3
Publisher Okayama University Medical School
Start Page 391
End Page 395
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34176945
Web of Science KeyUT 000667147700016
NAID 120007089821
JaLCDOI 10.18926/AMO/62228
FullText URL 75_3_335.pdf
Author Chikuie, Nobuyuki| Hamamoto, Takao| Ueda, Tsutomu| Taruya, Takayuki| Kono, Takashi| Furuie, Hiromi| Ishino, Takashi| Takeno, Sachio|
Abstract Recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC) has a poor prognosis. Although nivolumab is approved in Japan for treating R/MHNSCC, the response rate is low. Therefore, identifying pretreatment prognostic factors is necessary. This study assessed the utility of the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS) as biomarkers of response to nivolumab. We retrospectively collected the data of 56 R/MHNSCC patients treated with nivolumab between May 2017 and December 2019. The Kaplan–Meier method and log-rank test were used to estimate overall survival (OS) and progression-free survival (PFS), and multivariate Cox hazard regression analysis was used to identify independent predictors of survival. Patients with a low pretreatment NLR had prolonged OS, and patients with a low pretreatment GPS had increased OS and PFS. A performance score (PS) of 0-1, development of immune-related adverse events, and GPS of 0-1 were significantly associated with OS in multivariate analysis. In summary, baseline pretreatment NLR and GPS are independently associated with OS in R/MHNSCC patients treated with nivolumab. Administration of nivolumab while maintaining the PS reflects a immune status of the host and leads to a good OS.
Keywords neutrophil-to-lymphocyte ratio nivolumab Glasgow Prognostic Score recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC)
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-06
Volume volume75
Issue issue3
Publisher Okayama University Medical School
Start Page 335
End Page 343
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34176937
Web of Science KeyUT 000667147700008
NAID 120007089825
FullText URL fulltext20210623-1.pdf
Author Matsuo, Toshihiko| Liu, Shihui| Uchida, Tetsuya| Onoue, Satomi| Nakagawa, Shinsaku| Ishii, Mayumi| Kanamitsu, Kayoko|
Keywords NK-5962 photoelectric dye apoptosis retinal neuron neuroprotection pharmacokinetics ADME phototoxic/photosensitive assay reactive oxygen species assay photosafety
Published Date 2021-6-21
Publication Title Life
Volume volume11
Issue issue6
Publisher MDPI
Start Page 591
ISSN 2075-1729
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors
File Version publisher
DOI 10.3390/life11060591
NAID 120007089837
Related Url isVersionOf https://doi.org/10.3390/life11060591
FullText URL fulltext.pdf
Author Iwamuro, Masaya| Tanaka, Takehiro| Sugihara, Yuusaku| Harada, Keita| Hiraoka, Sakiko| Kondo, Yoshitaka| Okada, Hiroyuki|
Keywords endometriosis subepithelial lesion submucosal tumor cecum colonoscopy
Published Date 2021
Publication Title Internal Medicine
Volume volume60
Issue issue11
Publisher Japanese Society of Internal Medicine
Start Page 1697
End Page 1701
ISSN 0918-2918
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Japanese Society of Internal Medicine
File Version publisher
PubMed ID 33390498
DOI 10.2169/internalmedicine.6418-20
Web of Science KeyUT 000659353300007
Related Url isVersionOf https://doi.org/10.2169/internalmedicine.6418-20
FullText URL K0006417_abstract_review.pdf K0006417_fulltext.pdf
Author Jan, Yuyan|
Published Date 2021-03-25
Content Type Thesis or Dissertation
Grant Number 甲第6417号
Granted Date 2021-03-25
Thesis Type Doctor of Philosophy in Engineering
Grantor 岡山大学
language English
FullText URL fulltext.pdf
Author Fujiwara, Atsushi| Kanzaki, Yuki| Kimura, Shuhei| Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Morizane, Yuki|
Published Date 2021-04-07
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 33828222
DOI 10.1038/s41598-021-87440-3
NAID 120007037374
Web of Science KeyUT 000640395800029
Related Url isVersionOf https://doi.org/10.1038/s41598-021-87440-3
JaLCDOI 10.18926/AMO/61910
FullText URL 75_2_255.pdf
Author Himemiya-Hakucho, Ayako| Fujimiya, Tatsuya|
Abstract Alcohol has been identified as a potential precipitating factor for parasomnia, particularly sleepwalking (SW). We report an unusual case of a Japanese drunk driver who may have experienced alcohol-related SW, based on the statements of the suspect, pharmacokinetic analyses of the suspect’s breath alcohol concentration, testimonies of witnesses, driving recorder data, and medical records. The existence of sleep-related criminal acts performed while a suspect experiences memory loss under the influence of alcohol has not been sufficiently recognized, and awareness of such acts should be raised among the police, public prosecutors, and the general public in Japan.
Keywords drunk driving sleepwalking parasomnia amnesia blood alcohol concentration
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 255
End Page 259
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953435
NAID 120007029877
JaLCDOI 10.18926/AMO/61909
FullText URL 75_2_249.pdf
Author Sun, Weiying| Shiode, Yusuke| Tokumasu, Kazuki| Kimura, Shuhei| Hosokawa, Mio| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Otsuka, Fumio| Morizane, Yuki|
Abstract A 79-year-old woman presented to our hospital with a 10-day history of gradually worsening binocular vision and severe backache. Further investigations revealed poor bilateral best-corrected visual acuities (BCVA), bilateral vitreous opacities, gray-white lesions scattered throughout the retina, and a left iliopsoas abscess on CT that later grew out methicillin-sensitive S. aureus. The abscess was drained and intravenous antibiotics were initiated, but the left eye additionally required intravitreal vancomycin. BCVA for both eyes normalized within 1 year. Intramuscular abscess should be considered as a possible primary lesion in cases of endogenous bacterial endophthalmitis.
Keywords endogenous bacterial endophthalmitis methicillin-sensitive Staphylococcus aureus iliopsoas abscess intravitreal injection vancomycin
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 249
End Page 253
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953434
NAID 120007029878
JaLCDOI 10.18926/AMO/61894
FullText URL 75_2_153.pdf
Author Shimaoka, Shigeyoshi| Hamaoka, Hitomi| Inoue, Junji| Asanuma, Masato| Tooyama, Ikuo| Kondo, Yoichi|
Abstract Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms. Other biological functions of Lf include immunomodulation and transcriptional regulation. However, the roles of Lf in the CNS have yet to be fully clarified. In this study, we raised an antiserum against mouse Lf and investigated the immunohistochemical localization of Lf-like immunoreactivity (Lf-LI) throughout the CNS of adult mice. Lf-LI was found in some neuronal populations throughout the CNS. Intense labeling was found in neurons in the olfactory systems, hypothalamic nuclei, entorhinal cortex, and a variety of brainstem nuclei. This study provides detailed information on the Lf-LI distribution in the CNS, and the findings should promote further understanding of both the physiological and pathological significance of Lf in the CNS.
Keywords lactoferrin immunohistochemistry brain mapping
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 153
End Page 167
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953422
NAID 120007029892
FullText URL fulltext20210416.pdf
Author Yamashita, Koichiro| Tanaka, Tenu| Matsuo, Toshihiko| Uchida, Tetsuya|
Keywords retinal prosthesis photoelectric dye polyethylene film retinitis pigmentosa durability
Note This is an Accepted Manuscript of an article published by IOP| This fulltext is available in March 2022|
Published Date 2021-3-8
Publication Title Biomedical Materials
Volume volume16
Issue issue4
Publisher IOP Publishing
Start Page 045001
ISSN 1748-6041
NCID AA12157402
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version author
PubMed ID 33607636
DOI 10.1088/1748-605x/abe809
Web of Science KeyUT 000626891900001
Related Url isVersionOf https://doi.org/10.1088/1748-605x/abe809
FullText URL fulltext.pdf
Author Murata, Atsuo| Doi, Toshihisa| Kageyama, Kazushi| Karwowski, Waldemar|
Keywords Eye-gaze input target predictive method ballistic eye movement homing eye movement pointing time predictive accuracy Midas touch
Published Date 2021-01-29
Publication Title IEEE Access
Volume volume9
Publisher Institute of Electrical and Electronics Engineers
Start Page 22688
End Page 22697
ISSN 2169-3536
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
File Version publisher
DOI 10.1109/ACCESS.2021.3055514
Web of Science KeyUT 000617371800001
Related Url isVersionOf https://doi.org/10.1109/ACCESS.2021.3055514
FullText URL fulltext.pdf
Author Matsuo, Toshihiko| Uchida, Tetsuya|
Keywords artificial retina retinal prosthesis photoelectric dye polyethylene film monkey surgery multielectrode array dish recording vitrectomy disposable injector sustainable development goals
Published Date 2021
Publication Title Internal Medicine Review
Volume volume7
Issue issue1
Publisher National Library of Medicine
ISSN 2470-3524
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders 2020 Internal Medicine Review.
File Version publisher
DOI 10.18103/imr.v7i1.916
Related Url isVersionOf http://dx.doi.org/10.18103/imr.v7i1.916
FullText URL fulltext.pdf
Author Noda, Hiroshi| Kimura, Shuhei| Hosokawa Morizane, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Kanzaki, Yuki| Fujiwara, Atsushi| Morizane, Yuki|
Published Date 2020-12-09
Publication Title Scientific Reports
Volume volume10
Issue issue1
Publisher Nature Research
Start Page 21497
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2020
File Version publisher
PubMed ID 33299123
DOI 10.1038/s41598-020-78693-5
Web of Science KeyUT 000608953600006
Related Url isVersionOf https://doi.org/10.1038/s41598-020-78693-5
FullText URL fulltext.pdf
Author Shibata, Kiyo| Fujiwara, Atsushi| Hamasaki, Ichiro| Shimizu, Takehiro| Kono, Reika| Kanenaga, Keisuke| Nakazawa, Masanori| Morizane, Yuki|
Published Date 2020-12-23
Publication Title PLoS ONE
Volume volume15
Issue issue12
Publisher Public Library of Science
Start Page e0243382
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Shibata et al.
File Version publisher
PubMed ID 33362229
DOI 10.1371/journal.pone.0243382
Web of Science KeyUT 000603071600010
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0243382
JaLCDOI 10.18926/AMO/61205
FullText URL 74_6_467.pdf
Author Yokota, Yuya| Nishimura, Yoshito| Ando, Akemi| Hanayama, Yoshihisa| Hasegawa, Kou| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Ueda, Keigo| Otsuka, Fumio|
Abstract Alkaline phosphatase (ALP) is an enzyme that is expressed in a variety of tissues. Among the isoforms of ALP, bone-specific alkaline phosphatase (BAP) is used as a marker for evaluating bone metabolism. We investigated the clinical usefulness of the ratio of serum BAP to total ALP for the diagnosis of various disorders in general practice. We retrospectively analyzed the cases of 107 Japanese patients whose serum BAP levels were exam-ined, focusing on clinical characteristics. We observed that the BAP/ALP ratios of the patients with fever and those with inflammatory diseases were significantly lower than the ratios of other patient groups. The BAP/ALP ratios of the patients with osteoporosis and those with metabolic bone diseases were higher than those of the patients with other conditions. The BAP/ALP ratio was found to be negatively correlated with age, a cor-relation that has not been found in other ethnicities. The serum BAP/ALP ratio was inversely correlated with serum CRP levels but was positively correlated with serum albumin levels and hemoglobin concentrations. Collectively, our results suggest that the BAP/ALP ratio could be a useful predictor for important geriatric con-ditions seen in general practice.
Keywords alkaline phosphatase BAP CRP inflammation osteoporosis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2020-12
Volume volume74
Issue issue6
Publisher Okayama University Medical School
Start Page 467
End Page 474
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33361866
Web of Science KeyUT 000601203600002
NAID 120006948955
FullText URL fulltext.pdf
Author Takahashi, Kosuke| Kimura, Shuhei| Hosokawa, Mio Morizane| Shiode, Yusuke| Doi, Shinichiro| Matoba, Ryo| Kanzaki, Yuki| Yonekawa, Yoshihiro| Morizane, Yuki|
Keywords Case report Perfluorocarbon Retinal detachment Subretinal injection Vitreoretinal surgery
Published Date 2020-10-23
Publication Title BMC Ophthalmology
Volume volume20
Issue issue1
Publisher BMC
Start Page 427
ISSN 1471-2415
NCID AA12035369
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 33097007
DOI 10.1186/s12886-020-01698-1
Web of Science KeyUT 000586445100002
Related Url isVersionOf https://doi.org/10.1186/s12886-020-01698-1
FullText URL J_Invest_Med_HIgh_Inpact_Case_Rep_8.pdf
Author Matsuo, Toshihiko| Shimizu, Takehiro| Tanaka, Takehiro| Yamamoto, Akira| Takasuka, Hiroki|
Keywords adult T-cell leukemia/lymphoma vitreous opacity vitrectomy aqueous hypopyon aqueous tap cytology pathology Japanese literature review immunostaining
Published Date 2020-10-20
Publication Title Journal of Investigative Medicine High Impact Case Reports
Volume volume8
Publisher SAGE Publications
Start Page 2324709620966843
ISSN 2324-7096
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 American Federation for Medical Research
File Version publisher
DOI 10.1177/2324709620966843
Related Url isVersionOf https://doi.org/10.1177/2324709620966843