result 291 件
JaLCDOI | 10.18926/AMO/62378 |
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FullText URL | 75_4_403.pdf |
Author | Matoba, Ryo| Morizane, Yuki| |
Abstract | Epiretinal membrane (ERM) is a common retinal disease characterized by cellular proliferation and metaplasia that lead to the formation of a pathological fibrocellular membrane immediately superjacent to the inner retinal surface. The vast majority of ERMs are considered idiopathic. However, ERM formation can result from various primary intraocular diseases, including retinal breaks and detachment, retinal vascular diseases, and vitreoretinal inflammatory conditions. Although ERMs are generally asymptomatic or cause mild metamorphopsia and/or a modest decrease in visual acuity, some can cause severe macular distortion and macular edema, resulting in significantly impaired function. Surgical removal of ERM is the only treatment, and improvements in vitrectomy systems have enabled less invasive treatment. However, there are currently no standardized criteria for ERM surgery, and the indications for surgery are determined from the patient’s subjective symptoms. Another problem with ERM surgery is that not all patients show satisfactory postoperative recovery of visual function. Thus, further research is needed to determine the criteria for ERM surgery and methods to improve the postoperative prognosis. |
Keywords | epiretinal membrane vitrectomy optical coherence tomography internal limiting membrane lamellar macular hole |
Amo Type | Review |
Publication Title | Acta Medica Okayama |
Published Date | 2021-08 |
Volume | volume75 |
Issue | issue4 |
Publisher | Okayama University Medical School |
Start Page | 403 |
End Page | 413 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 34511606 |
Web of Science KeyUT | 000697944600001 |
NAID | 120007146059 |
FullText URL | fulltext20210726-1.pdf |
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Author | Liu, Shihui| Matsuo, Toshihiko| Miyaji, Mary| Hosoya, Osamu| |
Keywords | NK-4 retina apoptosis RNA-seq photoreceptor retinitis pigmentosa antioxidant metabolism |
Published Date | 2021-7-19 |
Publication Title | Pharmaceuticals |
Volume | volume14 |
Issue | issue7 |
Publisher | MDPI AG |
Start Page | 694 |
ISSN | 1424-8247 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
File Version | publisher |
DOI | 10.3390/ph14070694 |
Related Url | isVersionOf https://doi.org/10.3390/ph14070694 |
FullText URL | fulltext20210625-1.pdf |
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Author | Matsuo, Toshihiko| Tanaka, Takehiro| Nakamura, Aya| Wada, Koichiro| |
Keywords | prostate cancer choroidal/uveal tumor choroidal/uveal metastasis radiation surgical castration complete remission hormonal therapy literature review prostate-specific antigen PSA positron emission tomography PET |
Published Date | 2021-06-23 |
Publication Title | Journal of Investigative Medicine High Impact Case Reports |
Volume | volume8 |
Publisher | American Federation for Medical Research |
Start Page | 1 |
End Page | 8 |
ISSN | 2324-7096 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 American Federation for Medical Research |
File Version | publisher |
PubMed ID | 34159819 |
DOI | 10.1177/23247096211026471 |
NAID | 120007089816 |
Related Url | isVersionOf https://doi.org/10.1177/23247096211026471 |
JaLCDOI | 10.18926/AMO/62236 |
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FullText URL | 75_3_391.pdf |
Author | Fujiwara, Miyuki| Kimura, Shuhei| Morizane Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Kanzaki, Yuki | Morizane, Yuki| |
Abstract | A 58-year-old Japanese man underwent vitrectomy for rhegmatogenous retinal detachment (RRD) in 2002. Twelve years later, optical coherence tomography revealed the development of a lamellar macular hole; the visual acuity was 20/200. Two years later, because metamorphopsia and the foveal retina thinning were aggravated, epiretinal proliferation embedding was performed to restore the foveal structure by transplanting glial cells to the foveal cavity. The patient was followed-up for 4 years, and his macular morphology and visual acuity (20/66) improved. No complications occurred. This appears to be the first report of epiretinal proliferation embedding for a lamellar macular hole post-RRD repair. |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2021-06 |
Volume | volume75 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 391 |
End Page | 395 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 34176945 |
Web of Science KeyUT | 000667147700016 |
NAID | 120007089821 |
JaLCDOI | 10.18926/AMO/62228 |
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FullText URL | 75_3_335.pdf |
Author | Chikuie, Nobuyuki| Hamamoto, Takao| Ueda, Tsutomu| Taruya, Takayuki| Kono, Takashi| Furuie, Hiromi| Ishino, Takashi| Takeno, Sachio| |
Abstract | Recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC) has a poor prognosis. Although nivolumab is approved in Japan for treating R/MHNSCC, the response rate is low. Therefore, identifying pretreatment prognostic factors is necessary. This study assessed the utility of the neutrophil-to-lymphocyte ratio (NLR) and Glasgow Prognostic Score (GPS) as biomarkers of response to nivolumab. We retrospectively collected the data of 56 R/MHNSCC patients treated with nivolumab between May 2017 and December 2019. The Kaplan–Meier method and log-rank test were used to estimate overall survival (OS) and progression-free survival (PFS), and multivariate Cox hazard regression analysis was used to identify independent predictors of survival. Patients with a low pretreatment NLR had prolonged OS, and patients with a low pretreatment GPS had increased OS and PFS. A performance score (PS) of 0-1, development of immune-related adverse events, and GPS of 0-1 were significantly associated with OS in multivariate analysis. In summary, baseline pretreatment NLR and GPS are independently associated with OS in R/MHNSCC patients treated with nivolumab. Administration of nivolumab while maintaining the PS reflects a immune status of the host and leads to a good OS. |
Keywords | neutrophil-to-lymphocyte ratio nivolumab Glasgow Prognostic Score recurrent or metastatic head and neck squamous cell carcinoma (R/MHNSCC) |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2021-06 |
Volume | volume75 |
Issue | issue3 |
Publisher | Okayama University Medical School |
Start Page | 335 |
End Page | 343 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 34176937 |
Web of Science KeyUT | 000667147700008 |
NAID | 120007089825 |
FullText URL | fulltext20210623-1.pdf |
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Author | Matsuo, Toshihiko| Liu, Shihui| Uchida, Tetsuya| Onoue, Satomi| Nakagawa, Shinsaku| Ishii, Mayumi| Kanamitsu, Kayoko| |
Keywords | NK-5962 photoelectric dye apoptosis retinal neuron neuroprotection pharmacokinetics ADME phototoxic/photosensitive assay reactive oxygen species assay photosafety |
Published Date | 2021-6-21 |
Publication Title | Life |
Volume | volume11 |
Issue | issue6 |
Publisher | MDPI |
Start Page | 591 |
ISSN | 2075-1729 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 by the authors |
File Version | publisher |
DOI | 10.3390/life11060591 |
NAID | 120007089837 |
Related Url | isVersionOf https://doi.org/10.3390/life11060591 |
FullText URL | fulltext.pdf |
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Author | Iwamuro, Masaya| Tanaka, Takehiro| Sugihara, Yuusaku| Harada, Keita| Hiraoka, Sakiko| Kondo, Yoshitaka| Okada, Hiroyuki| |
Keywords | endometriosis subepithelial lesion submucosal tumor cecum colonoscopy |
Published Date | 2021 |
Publication Title | Internal Medicine |
Volume | volume60 |
Issue | issue11 |
Publisher | Japanese Society of Internal Medicine |
Start Page | 1697 |
End Page | 1701 |
ISSN | 0918-2918 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2021 The Japanese Society of Internal Medicine |
File Version | publisher |
PubMed ID | 33390498 |
DOI | 10.2169/internalmedicine.6418-20 |
Web of Science KeyUT | 000659353300007 |
Related Url | isVersionOf https://doi.org/10.2169/internalmedicine.6418-20 |
FullText URL | K0006417_abstract_review.pdf K0006417_fulltext.pdf |
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Author | Jan, Yuyan| |
Published Date | 2021-03-25 |
Content Type | Thesis or Dissertation |
Grant Number | 甲第6417号 |
Granted Date | 2021-03-25 |
Thesis Type | Doctor of Philosophy in Engineering |
Grantor | 岡山大学 |
language | English |
FullText URL | fulltext.pdf |
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Author | Fujiwara, Atsushi| Kanzaki, Yuki| Kimura, Shuhei| Hosokawa, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Morizane, Yuki| |
Published Date | 2021-04-07 |
Publication Title | Scientific Reports |
Volume | volume11 |
Issue | issue1 |
Publisher | Nature Research |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2021 |
File Version | publisher |
PubMed ID | 33828222 |
DOI | 10.1038/s41598-021-87440-3 |
NAID | 120007037374 |
Web of Science KeyUT | 000640395800029 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-021-87440-3 |
JaLCDOI | 10.18926/AMO/61910 |
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FullText URL | 75_2_255.pdf |
Author | Himemiya-Hakucho, Ayako| Fujimiya, Tatsuya| |
Abstract | Alcohol has been identified as a potential precipitating factor for parasomnia, particularly sleepwalking (SW). We report an unusual case of a Japanese drunk driver who may have experienced alcohol-related SW, based on the statements of the suspect, pharmacokinetic analyses of the suspect’s breath alcohol concentration, testimonies of witnesses, driving recorder data, and medical records. The existence of sleep-related criminal acts performed while a suspect experiences memory loss under the influence of alcohol has not been sufficiently recognized, and awareness of such acts should be raised among the police, public prosecutors, and the general public in Japan. |
Keywords | drunk driving sleepwalking parasomnia amnesia blood alcohol concentration |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2021-04 |
Volume | volume75 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 255 |
End Page | 259 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33953435 |
NAID | 120007029877 |
JaLCDOI | 10.18926/AMO/61909 |
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FullText URL | 75_2_249.pdf |
Author | Sun, Weiying| Shiode, Yusuke| Tokumasu, Kazuki| Kimura, Shuhei| Hosokawa, Mio| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Otsuka, Fumio| Morizane, Yuki| |
Abstract | A 79-year-old woman presented to our hospital with a 10-day history of gradually worsening binocular vision and severe backache. Further investigations revealed poor bilateral best-corrected visual acuities (BCVA), bilateral vitreous opacities, gray-white lesions scattered throughout the retina, and a left iliopsoas abscess on CT that later grew out methicillin-sensitive S. aureus. The abscess was drained and intravenous antibiotics were initiated, but the left eye additionally required intravitreal vancomycin. BCVA for both eyes normalized within 1 year. Intramuscular abscess should be considered as a possible primary lesion in cases of endogenous bacterial endophthalmitis. |
Keywords | endogenous bacterial endophthalmitis methicillin-sensitive Staphylococcus aureus iliopsoas abscess intravitreal injection vancomycin |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2021-04 |
Volume | volume75 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 249 |
End Page | 253 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33953434 |
NAID | 120007029878 |
JaLCDOI | 10.18926/AMO/61894 |
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FullText URL | 75_2_153.pdf |
Author | Shimaoka, Shigeyoshi| Hamaoka, Hitomi| Inoue, Junji| Asanuma, Masato| Tooyama, Ikuo| Kondo, Yoichi| |
Abstract | Lactoferrin (Lf) is an iron-binding glycoprotein mainly found in exocrine secretions and the secondary granules of neutrophils. In the central nervous system (CNS), expression of the Lf protein has been reported in the lesions of some neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis, as well as in the aged brain. Lf is primarily considered an iron chelator, protecting cells from potentially toxic iron or iron-requiring microorganisms. Other biological functions of Lf include immunomodulation and transcriptional regulation. However, the roles of Lf in the CNS have yet to be fully clarified. In this study, we raised an antiserum against mouse Lf and investigated the immunohistochemical localization of Lf-like immunoreactivity (Lf-LI) throughout the CNS of adult mice. Lf-LI was found in some neuronal populations throughout the CNS. Intense labeling was found in neurons in the olfactory systems, hypothalamic nuclei, entorhinal cortex, and a variety of brainstem nuclei. This study provides detailed information on the Lf-LI distribution in the CNS, and the findings should promote further understanding of both the physiological and pathological significance of Lf in the CNS. |
Keywords | lactoferrin immunohistochemistry brain mapping |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2021-04 |
Volume | volume75 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 153 |
End Page | 167 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33953422 |
NAID | 120007029892 |
FullText URL | fulltext20210416.pdf |
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Author | Yamashita, Koichiro| Tanaka, Tenu| Matsuo, Toshihiko| Uchida, Tetsuya| |
Keywords | retinal prosthesis photoelectric dye polyethylene film retinitis pigmentosa durability |
Note | This is an Accepted Manuscript of an article published by IOP| This fulltext is available in March 2022| |
Published Date | 2021-3-8 |
Publication Title | Biomedical Materials |
Volume | volume16 |
Issue | issue4 |
Publisher | IOP Publishing |
Start Page | 045001 |
ISSN | 1748-6041 |
NCID | AA12157402 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | author |
PubMed ID | 33607636 |
DOI | 10.1088/1748-605x/abe809 |
Web of Science KeyUT | 000626891900001 |
Related Url | isVersionOf https://doi.org/10.1088/1748-605x/abe809 |
FullText URL | fulltext.pdf |
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Author | Murata, Atsuo| Doi, Toshihisa| Kageyama, Kazushi| Karwowski, Waldemar| |
Keywords | Eye-gaze input target predictive method ballistic eye movement homing eye movement pointing time predictive accuracy Midas touch |
Published Date | 2021-01-29 |
Publication Title | IEEE Access |
Volume | volume9 |
Publisher | Institute of Electrical and Electronics Engineers |
Start Page | 22688 |
End Page | 22697 |
ISSN | 2169-3536 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
File Version | publisher |
DOI | 10.1109/ACCESS.2021.3055514 |
Web of Science KeyUT | 000617371800001 |
Related Url | isVersionOf https://doi.org/10.1109/ACCESS.2021.3055514 |
FullText URL | fulltext.pdf |
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Author | Matsuo, Toshihiko| Uchida, Tetsuya| |
Keywords | artificial retina retinal prosthesis photoelectric dye polyethylene film monkey surgery multielectrode array dish recording vitrectomy disposable injector sustainable development goals |
Published Date | 2021 |
Publication Title | Internal Medicine Review |
Volume | volume7 |
Issue | issue1 |
Publisher | National Library of Medicine |
ISSN | 2470-3524 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | 2020 Internal Medicine Review. |
File Version | publisher |
DOI | 10.18103/imr.v7i1.916 |
Related Url | isVersionOf http://dx.doi.org/10.18103/imr.v7i1.916 |
FullText URL | fulltext.pdf |
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Author | Noda, Hiroshi| Kimura, Shuhei| Hosokawa Morizane, Mio| Shiode, Yusuke| Doi, Shinichiro| Takahashi, Kosuke| Matoba, Ryo| Kanzaki, Yuki| Fujiwara, Atsushi| Morizane, Yuki| |
Published Date | 2020-12-09 |
Publication Title | Scientific Reports |
Volume | volume10 |
Issue | issue1 |
Publisher | Nature Research |
Start Page | 21497 |
ISSN | 2045-2322 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s) 2020 |
File Version | publisher |
PubMed ID | 33299123 |
DOI | 10.1038/s41598-020-78693-5 |
Web of Science KeyUT | 000608953600006 |
Related Url | isVersionOf https://doi.org/10.1038/s41598-020-78693-5 |
FullText URL | fulltext.pdf |
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Author | Shibata, Kiyo| Fujiwara, Atsushi| Hamasaki, Ichiro| Shimizu, Takehiro| Kono, Reika| Kanenaga, Keisuke| Nakazawa, Masanori| Morizane, Yuki| |
Published Date | 2020-12-23 |
Publication Title | PLoS ONE |
Volume | volume15 |
Issue | issue12 |
Publisher | Public Library of Science |
Start Page | e0243382 |
ISSN | 1932-6203 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 Shibata et al. |
File Version | publisher |
PubMed ID | 33362229 |
DOI | 10.1371/journal.pone.0243382 |
Web of Science KeyUT | 000603071600010 |
Related Url | isVersionOf https://doi.org/10.1371/journal.pone.0243382 |
JaLCDOI | 10.18926/AMO/61205 |
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FullText URL | 74_6_467.pdf |
Author | Yokota, Yuya| Nishimura, Yoshito| Ando, Akemi| Hanayama, Yoshihisa| Hasegawa, Kou| Hagiya, Hideharu| Ogawa, Hiroko| Obika, Mikako| Ueda, Keigo| Otsuka, Fumio| |
Abstract | Alkaline phosphatase (ALP) is an enzyme that is expressed in a variety of tissues. Among the isoforms of ALP, bone-specific alkaline phosphatase (BAP) is used as a marker for evaluating bone metabolism. We investigated the clinical usefulness of the ratio of serum BAP to total ALP for the diagnosis of various disorders in general practice. We retrospectively analyzed the cases of 107 Japanese patients whose serum BAP levels were exam-ined, focusing on clinical characteristics. We observed that the BAP/ALP ratios of the patients with fever and those with inflammatory diseases were significantly lower than the ratios of other patient groups. The BAP/ALP ratios of the patients with osteoporosis and those with metabolic bone diseases were higher than those of the patients with other conditions. The BAP/ALP ratio was found to be negatively correlated with age, a cor-relation that has not been found in other ethnicities. The serum BAP/ALP ratio was inversely correlated with serum CRP levels but was positively correlated with serum albumin levels and hemoglobin concentrations. Collectively, our results suggest that the BAP/ALP ratio could be a useful predictor for important geriatric con-ditions seen in general practice. |
Keywords | alkaline phosphatase BAP CRP inflammation osteoporosis |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2020-12 |
Volume | volume74 |
Issue | issue6 |
Publisher | Okayama University Medical School |
Start Page | 467 |
End Page | 474 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 33361866 |
Web of Science KeyUT | 000601203600002 |
NAID | 120006948955 |
FullText URL | fulltext.pdf |
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Author | Takahashi, Kosuke| Kimura, Shuhei| Hosokawa, Mio Morizane| Shiode, Yusuke| Doi, Shinichiro| Matoba, Ryo| Kanzaki, Yuki| Yonekawa, Yoshihiro| Morizane, Yuki| |
Keywords | Case report Perfluorocarbon Retinal detachment Subretinal injection Vitreoretinal surgery |
Published Date | 2020-10-23 |
Publication Title | BMC Ophthalmology |
Volume | volume20 |
Issue | issue1 |
Publisher | BMC |
Start Page | 427 |
ISSN | 1471-2415 |
NCID | AA12035369 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s). 2020 |
File Version | publisher |
PubMed ID | 33097007 |
DOI | 10.1186/s12886-020-01698-1 |
Web of Science KeyUT | 000586445100002 |
Related Url | isVersionOf https://doi.org/10.1186/s12886-020-01698-1 |
FullText URL | J_Invest_Med_HIgh_Inpact_Case_Rep_8.pdf |
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Author | Matsuo, Toshihiko| Shimizu, Takehiro| Tanaka, Takehiro| Yamamoto, Akira| Takasuka, Hiroki| |
Keywords | adult T-cell leukemia/lymphoma vitreous opacity vitrectomy aqueous hypopyon aqueous tap cytology pathology Japanese literature review immunostaining |
Published Date | 2020-10-20 |
Publication Title | Journal of Investigative Medicine High Impact Case Reports |
Volume | volume8 |
Publisher | SAGE Publications |
Start Page | 2324709620966843 |
ISSN | 2324-7096 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2020 American Federation for Medical Research |
File Version | publisher |
DOI | 10.1177/2324709620966843 |
Related Url | isVersionOf https://doi.org/10.1177/2324709620966843 |