result 146 件
| Title Alternative | Institutional Design of Bicameralism in the Legislative Process of the Constitution of Japan and the Diet Law : Case of Claim Provisions for Conference Committee of both Houses |
|---|---|
| FullText URL | olj_68_3-4_297_333.pdf |
| Author | Kinoshita, Kazuaki| |
| Publication Title | Okayama Law Journal |
| Published Date | 2019-03-19 |
| Volume | volume68 |
| Issue | issue3-4 |
| Start Page | 297 |
| End Page | 333 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| NAID | 120006603052 |
| FullText URL | Nat_Comm_9_2132.pdf |
|---|---|
| Author | Nishimura, Noriyuki| Tsuchiya, Wataru| Moresco, James J.| Hayashi, Yuki| Satoh, Kouji| Kaiwa, Nahomi| Irisa, Tomoko| Kinoshita, Toshinori| Schroeder, Julian I.| Yates III, John R.| Hirayama, Takashi| Yamazaki, Toshimasa| |
| Published Date | 2018-06-06 |
| Publication Title | Nature Communications |
| Volume | volume9 |
| Publisher | Springer Nature |
| Start Page | 2132 |
| ISSN | 2041-1723 |
| NCID | AA12645905 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 29875377 |
| DOI | 10.1038/s41467-018-04437-9 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-018-04437-9 |
| JaLCDOI | 10.18926/AMO/55582 |
|---|---|
| FullText URL | 71_6_459.pdf |
| Author | Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi| |
| Abstract | The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts. |
| Keywords | receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-12 |
| Volume | volume71 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 459 |
| End Page | 465 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29276218 |
| FullText URL | K0005298_other1.pdf |
|---|---|
| Author | Sakaguchi, Masakiyo| Murata, Hitoshi| Aoyama, Yumi| Hibino, Toshihiko| Widya Putranto, Endy| Winarsa Ruma, I. Made| Inoue, Yusuke| Sakaguchi, Yoshihiko| Yamamoto, Ken-ichi| Kinoshita, Rie| Futami, Junichiro| Kataoka, Ken| Iwatsuki, Keiji| Huh, Nam-ho| |
| Keywords | Cancer Cell Biology Keratinocyte Psoriasis Receptor for Advanced Glycation End Products (RAGE) |
| Note | 学位審査副論文| |
| Published Date | 2014-08 |
| Publication Title | Journal of Biological Chemistry |
| Volume | volume289 |
| Issue | issue34 |
| Publisher | American Society for Biochemistry and Molecular |
| Start Page | 23389 |
| End Page | 23402 |
| ISSN | 0021-9258 |
| NCID | AA00251083 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 25002577 |
| DOI | 10.1074/jbc.M114.573071 |
| Web of Science KeyUT | 000341505000014 |
| Related Url | https://doi.org/10.1074/jbc.M114.573071 http://ousar.lib.okayama-u.ac.jp/54281 |
| Title Alternative | Current state of and views regarding clinical approarches to Helicobacter pylori infection |
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| FullText URL | 128_13.pdf |
| Author | Okada, Hiroyuki| |
| Keywords | Helicobacter pylori 除菌療法 胃癌 胃炎 MALT リンパ腫 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2016-04-01 |
| Volume | volume128 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 19 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.13 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.13 |
| NAID | 130005149601 |
| Author | Takeda, Yoshimasa| Kawashima, Takahisa| Kiyota, Kazuya| Oda, Shigeto| Morimoto, Naoki| Kobata, Hitoshi| Isobe, Hisashi| Honda, Mitsuru| Fujimi, Satoshi| Onda, Jun| I, Seishi| Sakamoto, Tetsuya| Ishikawa, Masami| Nakano, Hiroshi| Sadamitsu, Daikai| Kishikawa, Masanobu| Kinoshita, Kosaku| Yokoyama, Tomoharu| Harada, Masahiro| Kitaura, Michio| Ichihara, Kiyoshi| Hashimoto, Hiroshi| Tsuji, Hidekazu| Yorifuji, Takashi| Nagano, Osamu| Katayama, Hiroshi| Ujike, Yoshihito| Morita, Kiyoshi| |
|---|---|
| Published Date | 2014-12 |
| Publication Title | Resuscitation |
| Volume | volume85 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Kinoshita, Rie| |
|---|---|
| Published Date | 2015-03-25 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Title Alternative | A case of microscopic low-grade appendiceal mucinous neoplasm complicated with appendicitis resected by reduced-port laparoscopic surgery |
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| FullText URL | 126_223.pdf |
| Author | Suzuki, Hiromitsu| Kimura, Kouji| Kinoshita, Sigeki| Okano, Kazuo| |
| Abstract | Appendicitis is a benign disease for which surgical treatment is widely provided. The complication of neoplastic lesions may be discovered only after resection. However, in some cases, specimens are not submitted to histopathological examination in Japan because of an extreme deficiency of pathologists. We report our experience with one patient who experienced the complication of latent low-grade appendiceal mucinous neoplasm (LAMN) after surgery for appendicitis. Our patient was an 85-year-old woman. Conservative treatment failed to relieve fever and lower abdominal pain and it was decided to treat her surgically. Abdominal computed tomography (CT) showed appendicitis with severe inflammation and suspected adhesion. We decided to explore the abdominal cavity using a reduced-port laparoscopic approach. We found no mucous debouchment or clear tumors in the specimen. Histopathological findings indicated the coexistence of appendicitis and LAMN. At one year and a half after surgery, there was no evidence of the development of pseudomyxoma peritonei. In appendectomy, it is thought that careful perioperative treatment and a postoperative pathological search are important when there are no preoperative findings suggesting a neoplastic lesion. |
| Keywords | 虫垂炎（appendicitis） 減孔式腹腔鏡手術（reduced-port laparoscopic surgery） 虫垂粘液嚢胞腺腫（low-grade appendiceal mucinous neoplasm (LAMN)） 腹膜偽粘液腫（pseudomyxoma peritonei） 腹腔鏡下虫垂切除術（laparoscopic appendectomy） |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-12-01 |
| Volume | volume126 |
| Issue | issue3 |
| Start Page | 223 |
| End Page | 226 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.223 |
| NAID | 130004903238 |
| Title Alternative | Metastatic breast cancer presenting as severe anemia, platelet reduction and abnormal cells in peripheral blood |
|---|---|
| FullText URL | 126_31.pdf |
| Author | Ota, Seisuke| Kasahara, Akinori| Mizuno, Shoma| Fukatsu, Haruka| Kinoshita, Osamu| Noguchi, Toshio| Kishimoto, Nobuyasu| Matsumura, Tadashi| |
| Abstract | Worldwide, breast cancer accounts for 22.9% of all cancers excluding non-melanoma skin cancers in women. More than 80% of breast cancer cases are discovered when a woman discovers a lump that feels different from the rest of the breast tissue. We report the case of a 60-year-old woman who had been treated for one year at a psychiatric hospital for suspected schizophrenia, and was referred to our hospital on March 23, 2011 for consultation regarding complete blood count abnormalities: hemoglobin, 4.8g/㎗ ; Plt, 1.9×104/μl ; WBC, 12,700/μl with 18.5% abnormal cells. Computed tomography revealed an enhanced, irregular mass in her right breast as well as right axillary lymph node swelling, suggestive of breast cancer. BM biopsy confirmed the presence of abnormal, keratin-positive cells, suggesting metastasis to the bone. CA15-3 was 300U/㎖ (normal range ＜25). The patient died on April 11, 2011, post-admission day 20. We found a rare case of terminal breast cancer that presented with peripheral blood abnormality. Breast cancer in patients who do not notice breast abnormality can present with peripheral blood abnormality. |
| Keywords | 乳癌（breast cancer） 初発症状（initial symptom） 貧血（anemia） 骨髄転移（bone marrow metastasis） |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 31 |
| End Page | 34 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.31 |
| Title Alternative | The mechanical stimulation of cells in 3D culture within a self-assembling peptide hydrogel |
|---|---|
| FullText URL | 126_7.pdf |
| Author | Nagai, Yusuke| Yokoi, Hidenori| Kaihara, Keiko| Naruse, Keiji| |
| Keywords | 機械刺激 メカノバイオロジー 自己集合性ペプチド ３次元培養 スキャフォールド |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2014-04-01 |
| Volume | volume126 |
| Issue | issue1 |
| Start Page | 7 |
| End Page | 10 |
| ISSN | 0030-1558 |
| Related Url | http://www.okayama-u.ac.jp/user/oma/ |
| language | Japanese |
| Copyright Holders | Copyright (c) 2014 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.126.7 |
| Author | Takata, Katsuyoshi| Sato, Yasuharu| Nakamura, Naoya| Tokunaka, Mami| Miki, Yukari| Kikuti, Yara Yukie| Igarashi, Kazuhiko| Ito, Etsuro| Harigae, Hideo| Kato, Seiichi| Hayashi, Eiko| Oka, Takashi| Hoshii, Yoshinobu| Tari, Akira| Okada, Hiroyuki| Mohamado, ABD Alkader Lamia| Maeda, Yoshinobu| Tanimoto, Mitsune| Kinoshita, Tomohiro| Yoshino, Tadashi| |
|---|---|
| Published Date | 2013-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/50409 |
|---|---|
| FullText URL | 67_3_165.pdf |
| Author | Shien, Tadahiko| Kinoshita, Takayuki| Seki, Kunihiko| Yoshida, Miwa| Hojo, Takashi| Shimizu, Chikako| Taira, Naruto| Doihara, Hiroyoshi| Akashi-Tanaka, Sadako| Tsuda, Hitoshi| Fujiwara, Yasuhiro| |
| Abstract | While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the National Cancer Center Hospital (NCCH). We analyzed EGFR, HER2, and p53 expression and common clinicopathological features from the CNB and surgical specimens of these patients. These biological markers were compared between sensitive patients (pathological complete response;pCR) and insensitive patients (clinical no change;cNC and clinical progressinve disease;cPD). In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC. p53 (p＝0.045) and histological grade 3 (p＝0.011) were important and significant predictors of the response to NAC. The correspondence rates for histological type, histological grade 3, ER, PgR, HER2, p53, and EGFR in insensitive patients between CNB and surgical specimens were 70%, 73%, 67%, 70%, 80%, 93%, and 73%. The pathologic response was significantly associated with p53 expression and histological grade 3. The correspondence rate of p53 expression between CNB and surgical specimens was higher than that of other factors. We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC. |
| Keywords | breast cancer neoadjuvant chemotherapy predictors |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 165 |
| End Page | 170 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804139 |
| Web of Science KeyUT | Pretreatment Specimen Predicts |
| Author | Kuroda, Satoshi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Muro, Takayuki| Kato, yukako| Matsushita, Tomohiro| Kinoshita, Toyohiko| Watanabe, Yoshio| Okazaki, Hiroyuki| Yokoya, Takayoshi| Sekiyama, Akira| Suga, higemasa| |
|---|---|
| Published Date | 2011-11 |
| Publication Title | Journal of Synchrotron Radiation |
| Volume | volume18 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | Kinoshita, Takafumi| |
|---|---|
| Published Date | 2012-03-23 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
| Author | Kawashima, Rieko| Matsunaga, Hisashi| Sendo, Toshiaki| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Satoh, Daisuke| Yagi, Takahito| Sadamori, Hiroshi| Umeda, Yuzo| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2011-12-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume123 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Kinoshita, Hiroshi| Nakayama, Takashi| Matsumoto, Naohiro| Ohmae, Nobuo| |
|---|---|
| Published Date | 2011-08 |
| Publication Title | Carbon |
| Volume | volume49 |
| Issue | issue10 |
| Content Type | Journal Article |
| Author | Kinoshita, Masayuki| |
|---|---|
| Published Date | 1930-11-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume42 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Kinoshita, Masayuki| |
|---|---|
| Published Date | 1931-03-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume43 |
| Issue | issue3 |
| Content Type | Journal Article |
