result 2820 件
| Title Alternative | The 2024 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2024 Sunada Prize) |
|---|---|
| Author | Kawana, Shinichi| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2025-12-01 |
| Volume | volume137 |
| Issue | issue3 |
| Start Page | 95 |
| End Page | 97 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.137.95 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2025 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.137.95 |
| Title Alternative | The 2024 Incentive Award of the Okayama Medical Association in Cancer Research (2024 Hayashibara Prize and Yamada Prize) |
|---|---|
| Author | Takihira, Shota| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2025-12-01 |
| Volume | volume137 |
| Issue | issue3 |
| Start Page | 89 |
| End Page | 91 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.137.89 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2025 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.137.89 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okamoto, Yasuhiro| Yamada, Yuki| Okada, Akira| Miyake, Masaki| Yamamura, Takeshi| Nagasaki, Katsutoshi| Nishi, Norio| |
| Keywords | welding copper aluminum insert metal intermetallic compound fiber laser blue laser angled irradiation |
| Published Date | 2025-02-01 |
| Publication Title | Journal of Laser Applications |
| Volume | volume37 |
| Issue | issue1 |
| Publisher | Laser Institute of America |
| Start Page | 012041 |
| ISSN | 1042-346X |
| NCID | AA11040115 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Author(s). |
| File Version | publisher |
| DOI | 10.2351/7.0001576 |
| Web of Science KeyUT | 001429132300001 |
| Related Url | isVersionOf https://doi.org/10.2351/7.0001576 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Zhao, Maoxiang| Galib, Md. Asadulla Al| Nakamura, Toshiyuki| Nakamura, Yoshimasa| Hirai, Yoshihiko| Nakashima, Yoshitaka| Munemasa, Shintaro| Mori, Izumi C.| Murata, Yoshiyuki| |
| Keywords | Rice · Salinity Apoplastic flow Trisodium-8-hydroxy-1,3,6-pyrenetrisulphonic acid Chitosan |
| Published Date | 2025-12-22 |
| Publication Title | Journal of Soil Science and Plant Nutrition |
| Publisher | Springer Science and Business Media LLC |
| ISSN | 0718-9508 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025 |
| File Version | publisher |
| DOI | 10.1007/s42729-025-02857-3 |
| Web of Science KeyUT | 001644294000001 |
| Related Url | isVersionOf https://doi.org/10.1007/s42729-025-02857-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Uemura, Mikiko| Maeshige, Noriaki| Yamaguchi, Atomu| Ma, Xiaoqi| Fu, Yunfei| Inoue, Taketo| Matsuda, Mami| Nishimura, Yuya| Hasunuma, Tomohisa| Wang, Ji| Kondo, Hiroyo| Fujino, Hidemi| |
| Keywords | microcurrent stimulation pentose phosphate pathway (PPP) NADPH oxidative stress macrophage glucose metabolism |
| Published Date | 2025-11-14 |
| Publication Title | Frontiers in Physiology |
| Volume | volume16 |
| Publisher | Frontiers Media SA |
| Start Page | 1666999 |
| ISSN | 1664-042X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 Uemura, Maeshige, Yamaguchi, Ma, Fu, Inoue, Matsuda, Nishimura, Hasunuma, Wang, Kondo and Fujino. |
| File Version | publisher |
| PubMed ID | 41321495 |
| DOI | 10.3389/fphys.2025.1666999 |
| Web of Science KeyUT | 001625379800001 |
| Related Url | isVersionOf https://doi.org/10.3389/fphys.2025.1666999 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tao, Kayoko| Yoshioka, Takako| Kato, Miho| Komatsu, Kazuyuki| Tsujimoto, Shinichi| Sakamoto, Kenichi| Tanimura, Kazuki| Sugiyama, Minako| Sekiguchi, Masahiro| Nakano, Yoshiko| Otani, Yoshihiro| Yatabe, Yasushi| Yoshida, Akihiko| Okita, Hajime| Hirato, Junko| Kohashi, Kenichi| Tanaka, Yukichi| Kohsaka, Shinji| Kubo, Takashi| Sunami, Kuniko| Hirata, Makoto| Tsutsumi, Shuichi| Aburatani, Hiroyuki| Koh, Katsuyoshi| Hirayama, Masahiro| Karakawa, Shuhei| Terashita, Yukayo| Fujisaki, Hiroyuki| Yagi, Takeshi| Yoneda, Akihiro| Mochizuki, Shinji| Shichino, Hiroyuki| Suzuki, Tatsuya| Takimoto, Tetsuya| Ichimura, Koichi| Ogawa, Chitose| Matsumoto, Kimikazu| Ichikawa, Hitoshi| Kato, Motohiro| |
| Keywords | genomic medicine integrative diagnosis molecularly targeted therapy multigene panel pediatric cancers |
| Published Date | 2025-11-17 |
| Publication Title | Cancer Science |
| Publisher | Wiley |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 41249692 |
| DOI | 10.1111/cas.70249 |
| Web of Science KeyUT | 001617093300001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.70249 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Okuda, Makoto| Suehiro, Yuto| Lapirattanakul, Jinthana| Naka, Shuhei| Matsumoto-Nakano, Michiyo| Nomura, Ryota| Okawa, Rena| Nakano, Kazuhiko| |
| Keywords | Collagen-binding protein gene cnm gene cbm gene Japan Multilocus sequence typing Serotype Streptococcus mutans |
| Published Date | 2025-11-25 |
| Publication Title | BMC Oral Health |
| Volume | volume25 |
| Issue | issue1 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1908 |
| ISSN | 1472-6831 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2025. |
| File Version | publisher |
| PubMed ID | 41291654 |
| DOI | 10.1186/s12903-025-07276-5 |
| Web of Science KeyUT | 001639848200001 |
| Related Url | isVersionOf https://doi.org/10.1186/s12903-025-07276-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sue, Mihiro| Watanabe, Mayu| Inoue, Ayumi| Katayama, Akihiro| Teshigawara, Sanae| Matsushita, Yuichi| Takeda, Masaya| Iseda, Izumi| Eguchi, Jun| Hida, Kazuyuki| |
| Keywords | glucagon-like peptide-1 (GLP-1) glucose-dependent insulinotropic polypeptide (GIP) maturity-onset diabetes in young (MODY) tirzepatide |
| Published Date | 2025-02 |
| Publication Title | Clinical Case Reports |
| Volume | volume13 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | e70173 |
| ISSN | 2050-0904 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 39902194 |
| DOI | 10.1002/ccr3.70173 |
| Web of Science KeyUT | 001411734700001 |
| Related Url | isVersionOf https://doi.org/10.1002/ccr3.70173 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Iwanaga, Joe| Kim, Hee‐Jin| Akita, Keiichi| Logan, Bari M.| Hutchings, Ralph T.| Ottone, Nicolás| Nonaka, Yoichi| Anand, Mahindra| Burns, Danny| Singh, Vishram| Peris‐Celda, Maria| Martinez‐Soriano, Francisco| Apaydin, Nihal| Hanna, Amgad| Yoshioka, Nobutaka| Fernandez‐Miranda, Juan| Hur, Mi‐Sun| Shoja, Mohammadali M.| Saremi, Farhood| Reina, Francisco| Tabira, Yoko| Carrera, Anna| Spratt, Jonathan D.| Ho, S. Yen| Mori, Shumpei| Komune, Noritaka| Watanabe, Koichi| Prats‐Galino, Alberto| De Andrés, Jose| Reina, Miguel Angel| Abrahams, Peter H.| Anderson, Robert H.| Ibaragi, Soichiro| Loukas, Marios| Tubbs, R. Shane| |
| Keywords | anatomy cadaver commercial consent dissection donors medical education medical ethics publishing |
| Published Date | 2025-01-04 |
| Publication Title | Clinical Anatomy |
| Volume | volume38 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | 222 |
| End Page | 225 |
| ISSN | 0897-3806 |
| NCID | AA10713797 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2025 The Author(s). |
| File Version | publisher |
| PubMed ID | 39754475 |
| DOI | 10.1002/ca.24258 |
| Web of Science KeyUT | 001389197500001 |
| Related Url | isVersionOf https://doi.org/10.1002/ca.24258 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ikezaki, Taichi| Sawada, Kenji| Kaneko, Osamu| |
| Keywords | cyberattack data-driven control cruise control FRIT poisoning attack |
| Published Date | 2025-12-20 |
| Publication Title | Journal of Robotics and Mechatronics |
| Volume | volume37 |
| Issue | issue6 |
| Publisher | Fuji Technology Press Ltd. |
| Start Page | 1392 |
| End Page | 1399 |
| ISSN | 1883-8049 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Fuji Technology Press Ltd. |
| File Version | publisher |
| DOI | 10.20965/jrm.2025.p1392 |
| Related Url | isVersionOf https://doi.org/10.20965/jrm.2025.p1392 |
| JaLCDOI | 10.18926/AMO/69851 |
|---|---|
| FullText URL | 79_6_469.pdf |
| Author | Tsujii, Teruyuki| Matsuda, Tatsuo| Kimura, Yuji| Katsube, Ryoichi| Iwadou, Hironori| Funabiki, Sadami| Kamikawa, Yasuaki| Matsuda, Tadakazu| |
| Abstract | We report a rare case of ileus tube-related intussusception in an adult. A 56-year-old man with adhesive bowel obstruction was treated with a nasointestinal ileus tube. Although his condition initially improved, persistent abdominal pain led to the diagnosis of intussusception via CT imaging. Manual repositioning of the tube resolved the intussusception without the need for bowel resection. A review of 80 previously reported cases of ileus tube-associated intussusception (total 81 cases, 95 lesions) highlighted the timing of onset, treatment strategies, and precautions. Early detection and diagnosis are crucial to prevent severe complications and preserve bowel function. |
| Keywords | nasointestinal ileus tube intussusception small bowel obstruction enterectomy conservative treatment |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 469 |
| End Page | 474 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443810 |
| Web of Science KeyUT | 001674277500010 |
| JaLCDOI | 10.18926/AMO/69850 |
|---|---|
| FullText URL | 79_6_463.pdf |
| Author | Asano, Yudai| Nishihara, Chika| Kitayama, Takahiro| Okawa, Nanako| Makimoto, Satoko| Higaki, Fumiyo| Kojima, Katsuhide| Sugihara, Hanako| Ida, Naoyuki| Yanai, Hiroyuki| Hiraki, Takao| |
| Abstract | We present a case of a woman in her 70s who was diagnosed with mesonephric adenocarcinoma of the uterine cervix, following biopsy and surgery. Preoperative MRI revealed a 7-cm, well-defined circumferential cervical mass with left lateral wall predominance, bulging into the uterine cavity and vagina. The lesion showed intermediate signal intensity on T2-weighted images, diffusion restriction, and early contrast enhancement weaker than that of the myometrium, followed by washout on contrast-enhanced imaging. The circumferential growth pattern with the lateral wall predominance and its imaging characteristics may suggest this rare entity be routinely included in the differential diagnosis of cervical cancers. |
| Keywords | mesonephric adenocarcinoma cervical cancer MRI imaging characteristics HPV-independent adenocarcinoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 463 |
| End Page | 468 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443809 |
| Web of Science KeyUT | 001674277500009 |
| JaLCDOI | 10.18926/AMO/69849 |
|---|---|
| FullText URL | 79_6_457.pdf |
| Author | Asakawa, Tomohiko| Uchida, Haruhito A.| Katayama, Yu| Sakurabu, Yoshimasa| Katayama, Katsuyoshi| Onishi, Yasuhiro| Matsuoka-Uchiyama, Natsumi| Takeuchi, Hidemi| Tanaka, Keiko| Tsuji, Kenji| Umebayashi, Ryoko| Takemoto, Rika| Wada, Jun| |
| Abstract | This case involves a 23-year-old male who was diagnosed with Behçet’s disease 5 years ago and managed with colchicine. Two months ago, he underwent renal biopsy due to abnormal urinalysis and kidney dysfunction, leading to a diagnosis of IgA nephropathy. He subsequently underwent tonsillectomy followed by glucocorticoid pulse therapy. However, after the tonsillectomy, discontinuing colchicine led to increased proteinuria, despite the glucocorticoid pulse therapy. Upon reintroducing colchicine, urinary protein excretion decreased, achieving incomplete remission. These findings suggest that colchicine may be effective in decreasing proteinuria in patients with Behçet’s disease complicated by IgA nephropathy. |
| Keywords | Behçet’s disease IgA nephropathy colchicine |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 457 |
| End Page | 461 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443808 |
| Web of Science KeyUT | 001674277500008 |
| JaLCDOI | 10.18926/AMO/69848 |
|---|---|
| FullText URL | 79_6_451.pdf |
| Author | Hagihara, Moe| Seike, Keisuke| Hayashino, Kenta| Yasuhara, Takao| Kin, Kyohei| Hirata, Yuichi| Kobayashi, Hiroki| Kitamura, Wataru| Fujiwara, Hideaki| Asada, Noboru| Fujii, Nobuharu| Maeda, Yoshinobu| |
| Abstract | Emicizumab, a bispecific monoclonal antibody, benefits patients with severe hemophilia A. It alters laboratory assessments of coagulation activity, requiring anti-idiotype monoclonal antibodies for accurate monitoring. A 64-year-old man, receiving emicizumab regularly, was admitted for laminoplasty. We planned to use FVIII replacement during the perioperative period after confirming the disappearance of inhibitors, monitoring coagulation activity with anti-idiotype monoclonal antibodies. Activated partial thromboplastin time was prolonged on postoperative day 2, prompting an immediate switch to eptacog alfa. The patient recovered without bleeding. This case underscores the necessity of anti-idiotype monoclonal antibodies for accurate monitoring. |
| Keywords | emicizumab eptacog alfa hemophilia A inhibitor anti-idiotype monoclonal antibodies to emicizumab |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 451 |
| End Page | 455 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443807 |
| Web of Science KeyUT | 001674277500007 |
| JaLCDOI | 10.18926/AMO/69847 |
|---|---|
| FullText URL | 79_6_445.pdf |
| Author | Matsumi, Junya| |
| Abstract | Our hospital began a PERIO program (perioperative patient management by a multi-disciplinary team from multiple departments) in 2016 to improve patient outcomes. We retrospectively analyzed the clinical effects of the PERIO program regarding the postoperative hospital stay (PHS) in the patients aged ≥ 18 years who underwent long lower-abdominal surgery at our hospital during the period April 2019 to March 2023. We excluded the cases of patients whose general anesthesia use was < 8 h, those for whom another surgery was performed simultaneously at another site, and emergency surgeries. The outcome was prolonged PHS, defined as exceeding the scheduled number of days specified in the patient’s clinical pathway. Among the 480 patients, prolonged PHS was observed for 270 patients (56.3%). In a multivariate logistic regression using advanced age, sex, high-risk general state, surgery requiring colon resection, serious adverse events (SAEs), and PERIO use, the following were associated with prolonged PHS: advance age (odds ratio [OR] 4.91, 95% confidence interval [CI]: 2.68-8.99, p=0.01), surgery requiring colon resection (OR 4.91, 95%CI: 2.68-8.99, p<0.001), SAE (OR 18.7, 95%CI: 7.22-48.2, p<0.001), and PERIO (OR 0.25, 95%CI: 0.13-0.47, p<0.001). The use of the PERIO program was thus beneficially associated with PHS after long lower-abdominal surgery. |
| Keywords | hospital stay ERAS surgery cancer perioperative management |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 445 |
| End Page | 449 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443806 |
| Web of Science KeyUT | 001674277500006 |
| JaLCDOI | 10.18926/AMO/69846 |
|---|---|
| FullText URL | 79_6_437.pdf |
| Author | Matsumi, Junya| Sato, Tetsufumi| |
| Abstract | The optimal indications for intensive care unit (ICU) treatment for critically ill cancer survivors whose condition has deteriorated due to medical factors are unclear. To test our hypothesis that frailty before deterioration was associated with hospital mortality in this patient population, we retrospective analyzed the cases of the patients admitted to the ICU at the National Cancer Center Hospital, Japan (April 2014-March 2022). We excluded patients who underwent surgery within 28 days or were denied critical care within 24 h or admitted after cardiopulmonary arrest. Their Clinical Frailty Scale (CFS) scores at 1 month before ICU admission (Pre-ICU) were obtained. Frailty was defined as CFS scores ≥4 points. We analyzed 298 admissions and observed that the mortality rate at hospital discharge was significantly higher in the frailty group (n=119). A multivariate analysis demonstrated that the following factors were significantly associated with hospital mortality: Pre-ICU frailty (OR 2.00, 95%CI: 1.19-3.36, p=0.009), cancer type (hematological: OR 2.93, 95%CI: 1.42-6.05, p=0.004), and Sequential Organ Failure Assessment score at ICU admission (OR 0.88, 95%CI: 0.82-0.95, p=0.0008). Frailty retrospectively assessed using the CFS at 1 month pre-ICU admission is a risk factor for hospital mortality in these cancer survivors. |
| Keywords | frailty cancer survivor clinical frailty scale cancer critically ill |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 437 |
| End Page | 444 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443805 |
| Web of Science KeyUT | 001674277500005 |
| JaLCDOI | 10.18926/AMO/69845 |
|---|---|
| FullText URL | 79_6_431.pdf |
| Author | Inoue, Takahiro| Kuwabara, Hiroyo| Yamamoto, Koh| |
| Abstract | The effect of weekend admission on patient mortality has been investigated in several therapeutic areas, including acute myeloid leukemia (AML), but the investigations’ results are controversial. We evaluated the relationship between in-hospital mortality and weekend admission in adult patients with AML in Japan by conducting a retrospective observational study using administrative data from 144 acute care hospitals from which patients were discharged between April 2014 and March 2019. The primary endpoint was in-hospital mortality, compared between weekend and weekday admissions. Among the 1,340 eligible patients, 11% (150) were admitted during a weekend. The in-hospital mortality rates of the patients admitted during weekends and those admitted on a weekday were 28% (42/150) and 17% (204/1190), respectively. After an adjustment for covariates, weekend admission was associated with a significantly higher risk of in-hospital mortality than weekday admission (HR 1.70, 95%CI: 1.20-2.40; p=0.003). However, such an association was not observed in patients treated in a bio-clean room (HR 1.26, 95%CI: 0.65-2.42). Our results demonstrate that for patients with AML, weekend admission was independently associated with a higher risk of death during hospitalization. An appropriate system is necessary for these patients. |
| Keywords | acute leukemia weekend admission in-hospital mortality bio-clean room |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 431 |
| End Page | 436 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443804 |
| Web of Science KeyUT | 001674277500004 |
| JaLCDOI | 10.18926/AMO/69844 |
|---|---|
| FullText URL | 79_6_421.pdf |
| Author | Tanaka, Ayumi| Naoe, Shota| Takenaka, Reiju| Kanzaki, Norie| Sakoda, Akihiro| Yamaoka, Kiyonori| Kataoka, Takahiro| |
| Abstract | Radon (222Rn; Rn) and thoron (220Rn; Tn) inhalation have been reported to enhance antioxidant activity in various organs. However, the effects of Tn on the colon have not been investigated. This study aimed to clarify the effects of Tn inhalation, alone and in combination with cyclosporin A (CsA), on dextran sulfate sodium (DSS)-induced colitis, and the accompanying oxidative stress, in mice. Male BALB/c mice were subjected to continuous 8-day Tn inhalation (c-Tn, 533±128 Bq/m3) or alternate-day Tn inhalation over the same period (f-Tn, 577±63Bq/m3), followed by treatment with 3% DSS and either CsA or vehicle for 7 days. Although the disease activity index (DAI) decreased significantly by day 2 in the c-Tn group, scores remained significantly higher than those in the f-Tn group. In the c-Tn group, superoxide dismutase and catalase activity in the colon were significantly elevated compared with those in sham controls. Thus, DSS-induced damage was effectively inhibited in the earlier stages by the c-Tn mode of inhalation than by the f-Tn mode. These findings suggest that continuous Tn inhalation more effectively attenuated early colitis symptoms than alternate-day inhalation, potentially through upregulation of antioxidant defenses. Tn and CsA showed no combined effects. |
| Keywords | thoron DSS antioxidant activity CsA colon |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 421 |
| End Page | 429 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443803 |
| Web of Science KeyUT | 001674277500003 |
| JaLCDOI | 10.18926/AMO/69843 |
|---|---|
| FullText URL | 79_6_413.pdf |
| Author | Jiang, Zhiyun| Xi, Ying| |
| Abstract | Several observational studies suggested that migraine headache attacks were associated with coronavirus disease 2019 (COVID-19). We investigated genetic causal links between COVID-19 phenotypes and the development of headache and migraine, including migraine with aura (MA) and migraine without aura (MO). We conducted a two-sample Mendelian randomization (MR) analysis to estimate the genetic association in European populations. The inverse-variance weighted (IVW) method was used as the main approach in the MR analyses, together with weighted median and MR-Egger methods. We also performed a series of sensitivity tests to assess the robustness of the MR results. The MR results demonstrated that COVID-19 severity, hospitalization, and susceptibility had no causal effect on the risks of headache, migraine, MA, or MO. No horizontal pleiotropy was detected, and the results were robust as supported by the sensitivity analysis findings. Our analyses identified no casual effect of COVID-19 severity, hospitalization, or susceptibility on the risks of headache or migraine in European populations. |
| Keywords | headache migraine Mendelian randomization COVID-19 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 413 |
| End Page | 419 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443802 |
| Web of Science KeyUT | 001674277500002 |
| JaLCDOI | 10.18926/AMO/69842 |
|---|---|
| FullText URL | 79_6_405.pdf |
| Author | Ouchi, Chihiro| Morizane Hosokawa, Mio| Kimura, Shuhei| Shiode, Yusuke| Matoba, Ryo| Morita, Tetsuro| Morizane, Yuki| |
| Abstract | We investigated the treatment outcomes of patients aged ≥85 years with neovascular age-related macular degeneration (nAMD) who received anti-vascular endothelial growth factor (anti-VEGF) therapy using either treat-and-extend (TAE) or pro re nata (PRN) regimens for 1 year in real-world clinical practice. Eighty-five eyes from 85 patients were included. Among them, types 1, 2, and 3 macular neovascularization and polypoidal choroidal vasculopathy were present in 27.1%, 17.6%, 18.8%, and 36.5%, respectively. TAE and PRN regimens were used in 43.5% and 56.5% of patients, respectively. At baseline, the PRN group was older and had worse best-corrected visual acuity (BCVA), greater central retinal thickness, and more intraretinal fluid than the TAE group. In the TAE group, the mean number of injections was 7.6, BCVA improved significantly, and all retinal fluid rates decreased. In the PRN group, the mean number of injections was 3.9, BCVA remained unchanged, and the rates of macular fibrosis and atrophy increased. No serious adverse events were observed in either group. Anti-VEGF therapy was safe for patients aged ≥ 85 years with nAMD, and the TAE regimen effectively improved BCVA in this population. BCVA remained unchanged in the PRN-treated patients, with baseline disease severity and/or undertreatment potentially influencing the outcomes. |
| Keywords | anti-vascular endothelial growth factor therapy neovascular age-related macular degeneration age treat-and-extend pro re nata |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2025-12 |
| Volume | volume79 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 405 |
| End Page | 412 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2025 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 41443801 |
| Web of Science KeyUT | 001674277500001 |
