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Title Alternative Understanding the pathogenesis of rare monogenic disorders and the social implementation of genomic medicine
Author Takenouchi, Toshiki|
Keywords 病態解明 希少遺伝性疾患 社会実装
Publication Title Journal of Okayama Medical Association
Published Date 2025-04-01
Volume volume137
Issue issue1
Start Page 10
End Page 14
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.137.10
language Japanese
Copyright Holders Copyright (c) 2025 岡山医学会
File Version publisher
DOI 10.4044/joma.137.10
FullText URL fulltext.pdf
Author Fukao, Takashi| Fujiwara, Masaki| Yamada, Yuto| Asada, Kazushi| Asada, Takahiro| Ri, Hirotoshi| Sakamoto, Shinji| Takaki, Manabu|
Keywords chronic pain electroconvulsive therapy pain disorder somatic symptom disorder
Published Date 2025-04-21
Publication Title Psychiatry and Clinical Neurosciences Reports
Volume volume4
Issue issue2
Publisher Wiley
Start Page e70108
ISSN 2769-2558
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40265150
DOI 10.1002/pcn5.70108
Web of Science KeyUT 001472473500001
Related Url isVersionOf https://doi.org/10.1002/pcn5.70108
FullText URL fulltext.pdf
Author Honda, Manami| Iwamuro, Masaya| Tanaka, Takehiro| Yamasaki, Yasushi| Kawano, Seiji| Hiraoka, Sakiko| Kawahara, Yoshiro| Otsuka, Motoyuki|
Keywords colonoscopy esophagogastroduodenoscopy gastrointestinal neoplasms gastrointestinal stromal tumor neurofibromatosis
Published Date 2025-04-16
Publication Title JGH Open
Volume volume9
Issue issue4
Publisher Wiley
Start Page e70151
ISSN 2397-9070
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40247846
DOI 10.1002/jgh3.70151
Web of Science KeyUT 001468535400001
Related Url isVersionOf https://doi.org/10.1002/jgh3.70151
JaLCDOI 10.18926/AMO/68654
FullText URL 79_2_139.pdf
Author Takeda, Yasushige| Noma, Kazuhiro| Maeda, Naoaki| Mizusawa, Yohei| Matsumoto, Hijiri| Kondo, Yuhei| Kunitomo, Tomoyoshi| Tanoue, Yukinori| Hashimoto, Masashi| Tanabe, Shunsuke| Fujiwara, Toshiyoshi|
Abstract In thoracic esophageal cancer, lymph node dissection around the recurrent laryngeal nerve is crucial but poses a risk of nerve palsy, affecting postoperative quality of life. In cases with an aberrant right subclavian artery (ARSA), the right recurrent laryngeal nerve is absent, and the non-recurrent inferior laryngeal nerve (NRILN) enters the larynx directly from the vagus nerve in the cervical region. Identifying the course of the NRILN is vital to avoid injury. A case of esophageal cancer with an ARSA, in which the course of the NRILN was preserved using the Nerve Integrity Monitoring (NIM) system during surgery, is described.
Keywords esophageal cancer intraoperative nerve monitoring aberrant right subclavian artery non-recurrent inferior laryngeal nerve thoracoscopic esophagectomy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-04
Volume volume79
Issue issue2
Publisher Okayama University Medical School
Start Page 139
End Page 144
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40302287
Web of Science KeyUT 001485501900001
JaLCDOI 10.18926/AMO/68653
FullText URL 79_2_135.pdf
Author Fujita, Yasufumi| Shimizu, Shuji| Mohri, Makoto|
Abstract Cardiac calcified amorphous tumor (CAT) is a rare, benign non-neoplastic mass of the heart that is sometimes found due to embolic events. Most cases of CAT are treated with surgical removal to prevent future embolic events. However, the treatment strategy for CAT complicated by atrial fibrillation has remained to be determined. Here we report a case of left ventricular CAT complicated by paroxysmal atrial fibrillation (PAF) that was successfully treated with surgical removal and pulmonary vein isolation. Pulmonary vein isolation can be a simple and effective procedure for PAF, even during surgical removal of CAT.
Keywords calcified amorphous tumor surgical removal embolic stroke paroxysmal atrial fibrillation pulmonary vein isolation
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-04
Volume volume79
Issue issue2
Publisher Okayama University Medical School
Start Page 135
End Page 138
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40302286
Web of Science KeyUT 001485501000001
JaLCDOI 10.18926/AMO/68649
FullText URL 79_2_109.pdf
Author Awai, Kyoko| Nakatsuka, Mikiya|
Abstract The status of postpartum depression was elucidated herein with the use of the Edinburgh Postnatal Depression Scale (EPDS) in women in Shikoku, Japan who became pregnant and gave birth after undergoing infertility treatment, including assisted reproductive technology (ART). The assessment was performed during their children’s 4-month health examination. The relationships between postpartum depression and the mothers’ background factors and scores on the Big Five personality traits scale were also examined. Of the Big Five personality traits, the scores for neuroticism were significantly higher in the ART group (n=71) than in the general infertility treatment (n=118) and natural pregnancy (n=872) groups. No significant differences in EPDS scores were seen among these three groups. A logistic regression analysis showed that neuroticism was associated with an EPDS score ≧9 points, (which is suggestive of postpartum depression, ) in all groups. Moreover, although a long-standing marriage had an inhibitory effect on postpartum depression in the natural pregnancy group, no such trend was seen in the ART group, which included many women with long-standing marriages. Particularly for women who become pregnant by ART, an individualized response that pays close attention to the woman’s personality traits is needed.
Keywords infertility treatment assisted reproductive technology postpartum postpartum depression personality trait
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-04
Volume volume79
Issue issue2
Publisher Okayama University Medical School
Start Page 109
End Page 116
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40302282
Web of Science KeyUT 001485544200006
JaLCDOI 10.18926/AMO/68648
FullText URL 79_2_101.pdf
Author Isozaki, Hiroshi| Matsumoto, Sasau| Takama, Takehiro| Isozaki, Yuka|
Abstract To evaluate the effectiveness of postoperative irradiation (POI) for patients with cN0 early breast cancer, we retrospectively analyzed the cases of 650 consecutive breast cancer patients who underwent sentinel lymph node (SLN)-guided surgery (2005-2022) at our hospital. In this cohort, 53% (278/521) of the patients who underwent breast conservative surgery (BCS) and 96% (124/129) of those treated with mastectomy did not receive POI. The patients who underwent BCS were treated with POI using opposing tangential field irradiation. A false negative (FN) SLN was retrospectively defined as a negative metastasis in SLN plus positive recurrence in the axillary lymph nodes. Recurrence was detected in 83 patients. A logistic regression analysis revealed that the nuclear grade (odds ratio [OR] 1.69), POI (OR 0.41), and postoperative hormone therapy (OR 0.40) were each significantly related to recurrence. The 26.1% (12/46) FN rate of the non-POI patients decreased to 5.8% (1/17) compared to those treated with POI. The rate of axillary recurrence was significantly lower in the POI group (0.4%) versus the non-POI group (2.7%) (p=0.0355). The rate of locoregional recurrence was also significantly lower in the POI group (2.0%) versus the non-POI group (13.4%) (p<0.0001). No significant difference was observed in the rate of distant recurrence between the POI (4.0%) and non-POI (3.3%) (p=0.831) groups. These results indicated that the postoperative opposing tangential field irradiation of conserved breast tissue inhibited recurrence in the axillary lymph nodes.
Keywords breast cancer postoperative irradiation radiation therapy sentinel lymph nodes recurrence
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-04
Volume volume79
Issue issue2
Publisher Okayama University Medical School
Start Page 101
End Page 107
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40302281
Web of Science KeyUT 001485544200005
JaLCDOI 10.18926/AMO/68647
FullText URL 79_2_093.pdf
Author Tsuchie, Rina| Fukuda, Mari| Tsumura, Hideki| Kinuta, Minako| Hisamatsu, Takashi| Kanda, Hideyuki|
Abstract School teachers are subject to both physical and mental health problems. We examined cross-sectional relationships between work engagement and major health outcomes among junior and senior high school teachers in Japan via a nationwide survey in 2019-2020. A total of 3,160 respondents were included in the analyses (19.9% response rate). Work engagement was assessed with the Utrecht Work Engagement Scale-9 (UWES-9), and we thus divided the teachers into quartiles according to their UWES-9 scores. Based on validated questionnaires, we assessed insomnia, psychological distress, and neck pain as health outcomes. A binomial logistic regression adjusted for age, gender, school type, teacher’s roles, involvement in club activities, division of duties, employment status, and whether they lived with family demonstrated that the teachers with lower UWES-9 scores had higher burdens of insomnia, psychological distress, and neck pain (odds ratios [95% confidence intervals] in 4th vs. 1st quartile, 2.92 (2.34-3.65), 3.70 (2.81-4.88), and 2.12 (1.68-2.68), respectively; all trend p<0.001). There were no significant differences in these associations between full-time and part-time teachers. Our findings indicate that low work engagement may contribute to physical and mental health issues among junior and senior high school teachers, thus providing insights for preventing health problems in this profession.
Keywords work engagement school teachers insomnia psychological distress neck pain
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-04
Volume volume79
Issue issue2
Publisher Okayama University Medical School
Start Page 93
End Page 100
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40302280
Web of Science KeyUT 001485544200004
JaLCDOI 10.18926/AMO/68644
FullText URL 79_2_065.pdf
Author Maki, Masatoshi| Takada, Ryo| Ishigo, Tomoyuki| Fujiwara, Miki| Takahashi, Yoko| Otsuka, Shinya| Tamura, Koji| Hamaoka, Terutaka|
Abstract Anamorelin (ANAM) is used to treat cancer-associated cachexia, a syndrome involving muscle loss and anorexia. The timing of the initiation of ANAM treatment is crucial to its efficacy. Although the body mass index (BMI) is a diagnostic criterion for cancer cachexia, no studies have explored its association with ANAM efficacy. We conducted a single-center, retrospective cohort study to investigate the association between the pre-treatment BMI and ANAM efficacy in patients with cancer-associated cachexia (n=47). The ANAM treatment was considered effective if the patient’s appetite improved within 30 days of treatment initiation. We calculated a BMI cutoff value (19.5 kg/m2) and used it to divide the patients into high- and low-BMI groups. Their background, clinical laboratory values, cancer types, and treatment lines were investigated. Twenty (42.6%) had a high BMI (≥ 19.5 kg/m2) and 27 (57.4%) had a low BMI (< 19.5 kg/m2). High BMI was significantly associated with ANAM effectiveness (odds ratio 7.86, 95% confidence interval 1.99-31.00, p=0.003). Together these results indicate that it is beneficial to initiate ANAM treatment before a patient’s BMI drops below 19.5 kg/m2. Our findings will help advance cancer cachexia treatment and serve as a reference for clinicians to predict ANAM’s efficacy.
Keywords anamorelin cancer-associated cachexia body mass index albumin efficacy rate
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-04
Volume volume79
Issue issue2
Publisher Okayama University Medical School
Start Page 65
End Page 73
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40302277
Web of Science KeyUT 001485544200001
FullText URL fulltext.pdf
Author Yamaguchi, Saki| Ishikawa, Kazuya| Furuta, Kazuyuki| Kaito, Chikara|
Keywords wzxE flippase enterobacterial common antigen low pH low temperature hyperosmotic stress
Published Date 2025-04-10
Publication Title Applied and Environmental Microbiology
Publisher American Society for Microbiology
ISSN 0099-2240
NCID AA00543249
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Yamaguchi et al.
File Version publisher
PubMed ID 40207904
DOI 10.1128/aem.02595-24
Web of Science KeyUT 001462873400001
Related Url isVersionOf https://doi.org/10.1128/aem.02595-24
FullText URL interdisciplinary_5_contents_e.pdf
Publication Title Interdisciplinary Science
Published Date 2025-03-31
Volume volume5
ISSN 2436-3227
language Japanese
File Version publisher
FullText URL fulltext.pdf
Author Tamura, Masanori| Furumatsu, Takayuki| Kitayama, Takahiro| Yokoyama, Yusuke| Okazaki, Yuki| Kawada, Koki| Ozaki, Toshifumi|
Keywords Medial meniscus Posterior root tear Distance Pullout repair Second-look arthroscopy
Published Date 2025-04-03
Publication Title Knee Surgery & Related Research
Volume volume37
Issue issue1
Publisher Springer Nature
Start Page 16
ISSN 2234-2451
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
PubMed ID 40181486
DOI 10.1186/s43019-025-00264-7
Web of Science KeyUT 001459123500001
Related Url isVersionOf https://doi.org/10.1186/s43019-025-00264-7
FullText URL fulltext.pdf
Author Al-Hammad, Wlla E.| Kuroda, Masahiro| Al Jamal, Jamal, Ghaida| Fujikura, Mamiko| Kamizaki, Ryo| Kuroda, Kazuhiro| Yoshida, Suzuka| Nakamura, Yoshihide| Oita, Masataka| Tanabe, Yoshinori| Sugimoto, Kohei| Sugianto, Irfan| Barham, Majd| Tekiki, Nouha| Hisatomi, Miki| Asaumi, Junichi|
Keywords breast cancer radiation therapy heart dose cut-off value machine learning robustness instability F2 score deep inspiration breath-hold technique computed tomography
Published Date 2025-03-10
Publication Title Diagnostics
Volume volume15
Issue issue6
Publisher MDPI
Start Page 668
ISSN 2075-4418
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 40150011
DOI 10.3390/diagnostics15060668
Web of Science KeyUT 001452220400001
Related Url isVersionOf https://doi.org/10.3390/diagnostics15060668
FullText URL fulltext.pdf
Author Miyai, Hisataka| Tomofuji, Takaaki| Mizuno, Hirofumi| Morita, Manabu| Nakahara, Momoko| Kataoka, Kota| Sumita, Ichiro| Uchida, Yurika| Toyama, Naoki| Yokoi, Aya| Yamanaka-Kohno, Reiko| Takeuchi, Noriko| Maruyama, Takayuki| Ekuni, Daisuke|
Keywords halitosis trehalose oral dryness cross-over study randomized trial
Published Date 2025-03-13
Publication Title Healthcare
Volume volume13
Issue issue6
Publisher MDPI
Start Page 619
ISSN 2227-9032
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 by the authors.
File Version publisher
PubMed ID 40150469
DOI 10.3390/healthcare13060619
Web of Science KeyUT 001452703300001
Related Url isVersionOf https://doi.org/10.3390/healthcare13060619
Title Alternative Summary of Research Activities : Okayama Administrative Law Research Group
FullText URL orl_026_143_144.pdf
Publication Title Okayama Law Review
Published Date 2025-03
Volume volume26
Start Page 143
End Page 144
ISSN 1881-1485
language Japanese
File Version publisher
JaLCDOI 10.18926/bgeou/68560
Title Alternative Student Evaluation of a Revised Course of Sociology Lectures in the Liberal-arts Education
FullText URL bgeou_109_115_130.pdf
Author NOBE, Masao|
Abstract  私は平成10年度の前期に一般科目(一般教養科目)の「社会学」の授業を担当した。本稿では,受講学生の授業評価などにより,その授業を検討し,次の3点を明らかにした。(1)私は,映画やドキュメンタリーを上映したり「講義ノート」を配布することで,社会学の授業を理解しやすくするように努めた。また,書評レポートを学生に書かせ論文作成の基礎を学ばせようとした。学生は,これらの授業改善をかなり評価していた。それから,授業のやり方や講義内容でとりたてて問題点はなかった。(2)多くの学生は,映画を上映したとき,授業時間が延長になることに苦情を持っていた。私は学生があげた苦情を解決しようと授業中に努力したが,大部分の苦情は私の努力ではどうにもできないものであった。(3)大学の当局や事務担当者には,次の2つが望まれる。第1に, 2時限連続の授業を設けることができるようにするなど,授業の性格に応じてより柔軟に,授業を開講できるようすべきだ。もしこれが可能であれば,私の授業に対する学生の苦情はほとんどなかった。第2に,シラバスを全学部の学生に配布するとか,インターネットで誰でも簡単に閲覧できるようにすべきだ。
 次に,授業の改善として,私は次の3点を提案した。(1)研究の方法を一般教育課程で学生に組織的に教えること。(2)大学の授業を他の教官に公開することによって,授業の改善に努めること。(3)教官の授業負担を軽減し,授業の充実をはかること。
Keywords 社会学 授業改善 授業評価
Publication Title Bulletin of Faculty of Education,Okayama University
Published Date 1998-11-13
Volume volume109
Start Page 115
End Page 130
ISSN 0471-4008
language Japanese
File Version publisher
JaLCDOI 10.18926/bgeou/68559
Title Alternative Student Evaluation of a Revised Course of Sociology Lectures in the Professional Education
FullText URL bgeou_110_121_129.pdf
Author NOBE, Masao|
Abstract  私は平成10年度の前期に教育学部の専門科目である「社会学A」の授業を担当した。本稿では,受講学生の授業評価により,その授業を検討し,次の3点を明らかにした。(1)私は,映画やドキュメンタリーを上映したり「講義ノート」を配布することで,社会学の授業を理解しやすくするように努めた。また,書評レポートを学生に書かせ論文作成の基礎を学ばせようとした,学生は,これらの授業改善をかなり評価していた。また,学生は授業での話し方や講義内容も好意的に評価していた。逆に,悪かった点は,授業の補講を土曜日の1日に集中して実施したことであった。これ以外では, とくに悪い点は指摘されなかった。その結果,学生は86.2点と比較的高めに私の授業を採点した。(2)書評レポートを学生に課すとき,その見本を学生に配布すると,書評レポートの質が大幅に向上する。(3)学生は私の授業を好意的にとらえていたけれど,受講学生数は少なかった。これから,受講学生数は主に授業の単位取得が容易かどうかによって決まってしまうと考えられる。
Keywords 社会学 専門科目 授業改善 授業評価
Publication Title Bulletin of Faculty of Education,Okayama University
Published Date 1999-03-15
Volume volume110
Start Page 121
End Page 129
ISSN 0471-4008
language Japanese
File Version publisher
JaLCDOI 10.18926/bgeou/68557
Title Alternative Elderly Women's Personal Networks and Subjective Well-being in Takahashi City, Japan: Initial Findings
FullText URL bgeou_112_057_078.pdf
Author NOBE, Masao|
Abstract  筆者は,平成9年から平成10年にかけて高齢女性を対象に岡山県高梁市において集団加入やパーソナル・ネットワークに関する調査を実施した。本稿では,この調査の概要を説明し,単純集計表を提示した。そして,このデータを用いて,高梁市への流入過程,身体的健康,身体的活動能力,モラール,生活満足度,各種の集団への加入,町内会などがおこなう活動への参加,パーソナル・ネットワークについて検討をおこなった。さて,高梁市は都市部(=市街地)と農村部からなりたっているが,都市部と農村部で暮らす高齢女性の違いについても考察した。
Keywords 高齢女性 パーソナル・ネットワーク 主観的幸福感 集団加入
Publication Title Bulletin of Faculty of Education,Okayama University
Published Date 1999-11-15
Volume volume112
Start Page 57
End Page 78
ISSN 0471-4008
language Japanese
File Version publisher
JaLCDOI 10.18926/bgeou/68553
Title Alternative The Life Styles of Elderly Women in the Urban Areas of Takahashi City, Japan-Part 1
FullText URL bgeou_116_043_053.pdf
Author NOBE, Masao|
Abstract  筆者は2000年10月から11月にかけて高梁市の市街地に住む高齢女性に聞き取り調査をおこなった。本稿では,収集した事例のうちから6つの事例を提示し,これを検討することによって,地方小都市の市街地に住む高齢女性がどのような暮らしをしているかを明らかにした。
Keywords 高梁市 市街地 高齢女性 高齢化
Publication Title Bulletin of Faculty of Education,Okayama University
Published Date 2001-03-15
Volume volume116
Start Page 43
End Page 53
ISSN 0471-4008
language Japanese
File Version publisher
JaLCDOI 10.18926/bgeou/68552
Title Alternative The Life Styles of Elderly Women in the Urban Areas of Takahashi City, Japan-PartII
FullText URL bgeou_117_035_041.pdf
Author NOBE, Masao|
Abstract  筆者は2000年10月から11月にかけて高梁市の市街地に住む高齢女性に聞き取り調査をおこなった。本稿では,収集した事例のうちから6つの事例を提示し,これを検討することによって,地方小都市の市街地に住む高齢女性がどのような暮らしをしているかを明らかにした。
Keywords 高梁市 市街地 高齢女性 高齢化
Publication Title Bulletin of Faculty of Education,Okayama University
Published Date 2001-07-15
Volume volume117
Start Page 35
End Page 41
ISSN 0471-4008
language Japanese
File Version publisher