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Author Kato, Mari| Tanai, Airi| Fukuhara, Yoko| Zheng, Xinyu| Sitosari, Heriati| Yamamoto, Tadashi| Ikegame, Mika| Okamura, Hirohiko|
Keywords β-catenin Gsk-3β LLPS Wnt
Published Date 2024
Publication Title Journal of Hard Tissue Biology
Volume volume33
Issue issue4
Publisher Society for Hard Tissue Regenerative Biology
Start Page 213
End Page 218
ISSN 1341-7649
NCID AA11074332
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © by The Hard Tissue Biology Network Association(JHTBNet)
File Version publisher
DOI 10.2485/jhtb.33.213
Web of Science KeyUT 001378221300001
Related Url isVersionOf https://doi.org/10.2485/jhtb.33.213
Title Alternative The 2023 Incentive Award of the Okayama Medical Association in Cancer Research (2023 Hayashibara Prize and Yamada Prize)
Author Obata, Taisuke|
Publication Title Journal of Okayama Medical Association
Published Date 2024-12-02
Volume volume136
Issue issue3
Start Page 94
End Page 96
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.136.94
language Japanese
Copyright Holders Copyright (c) 2024 岡山医学会
File Version publisher
DOI 10.4044/joma.136.94
JaLCDOI 10.18926/AMO/67870
FullText URL 78_6_449.pdf
Author Kato, Gentaro| Ogawa, Tatsuya| Hayashida, Tomohiro| Shimizu, Shuji| Yamamoto, Shu| Shichijo, Takeshi|
Abstract A 73-year-old man who had undergone esophagectomy and retrosternal gastric tube reconstruction for esophageal cancer 8 years prior was transferred to our hospital for the treatment of an acute myocardial infarction. Emergent percutaneous coronary intervention for the left anterior descending artery (#7) was successfully performed. However, echocardiography revealed a ventricular septal rupture (25×27 mm). Seventeen days after admission, the rupture was successfully treated with a double-patch closure via a left anterolateral thoracotomy to avoid a surgical injury to his retrosternal gastric tube. Determining the best surgical approach to the heart is important for safe cardiac surgery in patients after esophageal reconstruction.
Keywords acute myocardial infarction ventricular septal rupture retrosternal gastric tube reconstruction esophageal cancer left anterolateral thoracotomy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-12
Volume volume78
Issue issue6
Publisher Okayama University Medical School
Start Page 449
End Page 452
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39719317
Web of Science KeyUT 001397799300003
JaLCDOI 10.18926/AMO/67869
FullText URL 78_6_439.pdf
Author Yamashita, Mampei| Tanaka, Takayuki| Sumida, Yorihisa| Yamazaki, Shoto| Hara, Yuki| Fukuda, Akiko| Hisanaga, Makoto| Wakata, Koki| Araki, Masato| Eguchi, Susumu|
Abstract Gangrenous cholecystitis (GC) is classified as moderate acute cholecystitis according to the Tokyo Guidelines from 2018 (TG18). We evaluated the risk factors for GC and the outcomes of early cholecystectomy. A total of 136 patients who underwent emergency cholecystectomy for acute cholecystitis were retrospectively analyzed; 58 of these patients (42.6%) were diagnosed with GC (GC group) based on our retrospective pathologic diagnosis. We comparatively evaluated the patient backgrounds and surgical outcomes between the GC group and non-GC group. The GC group was significantly older and included more hypertensive patients than the non-GC group. The GC group was prescribed more antibiotics as initial treatment than the non-GC group, and they had more days between onset and surgery. The preoperative white blood cell count and C-reactive protein values were significantly higher in the GC group than in the non-GC group, and these values were predictive factors for GC. Cholecystectomy required a longer operation time and caused greater blood loss in the GC group. The GC group also had longer hospitalization times than the non-GC group; however, no significant differences were observed in terms of postoperative complications. In conclusion, gangrenous changes should be assessed when diagnosing cholecystitis, and appropriate treatment, such as surgery or drainage, should be undertaken.
Keywords gangrenous cholecystitis acute cholecystitis laparoscopic cholecystectomy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-12
Volume volume78
Issue issue6
Publisher Okayama University Medical School
Start Page 439
End Page 447
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39719316
Web of Science KeyUT 001397799300002
FullText URL fulltext.pdf
Author Futagawa, Mashu| Okazaki, Tetsuya| Nakata, Eiji| Fukano, Chika| Osumi, Risa| Kato, Fumino| Urakawa, Yusaku| Yamamoto, Hideki| Ozaki, Toshifumi| Hirasawa, Akira|
Note The version of record of this article, first published in Human Genome Variation, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41439-024-00299-4|
Published Date 2024-11-26
Publication Title Human Genome Variation
Volume volume11
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 42
ISSN 2054-345X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 39592598
DOI 10.1038/s41439-024-00299-4
Web of Science KeyUT 001363412200001
Related Url isVersionOf https://doi.org/10.1038/s41439-024-00299-4
FullText URL K0007103_abstract_review.pdf K0007103_fulltext.pdf K0007103_summary.pdf
Author OBATA, Taisuke|
Published Date 2024-09-25
Content Type Thesis or Dissertation
Grant Number 甲第7103号
Granted Date 2024-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2023 The Author(s).
FullText URL K0007102_abstract_review.pdf K0007102_fulltext.pdf K0007102_summary.pdf
Author ODA, Takashi|
Published Date 2024-09-25
Content Type Thesis or Dissertation
Grant Number 甲第7102号
Granted Date 2024-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2024 The Author(s).
FullText URL K0007098_abstract_review.pdf K0007098_fulltext.pdf K0007098_summary.pdf
Author AKAI, Masaaki|
Published Date 2024-09-25
Content Type Thesis or Dissertation
Grant Number 甲第7098号
Granted Date 2024-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © The Author(s) 2024
FullText URL K0007093_abstract_review.pdf K0007093_fulltext.pdf K0007093_other_figure.pdf K0007093_other1_Supplementary Figure.pdf K0007093_other2_Supplementary table.pdf K0007093_summary.pdf
Author KOBAYASHI, Teruki|
Published Date 2024-09-25
Content Type Thesis or Dissertation
Grant Number 甲第7093号
Granted Date 2024-09-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders ©2024 American Association for Cancer Research
FullText URL fulltext.pdf
Author Nishimura, Seitaro| Noma, Kazuhiro| Kawasaki, Kento| Hashimoto, Masashi| Kato, Takuya| Maeda, Naoaki| Tanabe, Shunsuke| Shirakawa, Yasuhiro| Fujiwara, Toshiyoshi|
Keywords Gastro-tracheal fistula Esophageal cancer Retrosternal route Esophageal surgery
Note The version of record of this article, first published in Surgical Case Reports, is available online at Publisher’s website: http://dx.doi.org/10.1186/s40792-024-02052-z|
Published Date 2024-11-04
Publication Title Surgical Case Reports
Volume volume10
Issue issue1
Publisher Springer
Start Page 252
ISSN 2198-7793
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024.
File Version publisher
PubMed ID 39489816
DOI 10.1186/s40792-024-02052-z
Web of Science KeyUT 001347685400001
Related Url isVersionOf https://doi.org/10.1186/s40792-024-02052-z
JaLCDOI 10.18926/AMO/67667
FullText URL 78_5_423.pdf
Author Sakamoto, Shinya| Tabuchi, Motoyasu| Yoshimatsu, Rika| Hishida, Ai| Matsumoto, Manabu| Iwata, Jun| Okabayashi, Takehiro|
Abstract Nesidioblastosis, also known as persistent hyperinsulinemic hypoglycemia, is usually observed in children and infants, although more recently adult-onset nesidioblastosis has also been described. We present a case of nesidioblastosis in a 78-year-old man that was detected by 111In-pentetreotide single photon emission computed tomography (SPECT/CT). The patient was transferred to our hospital’s emergency department in a hypoglycemic coma. Dynamic enhanced CT could detect no lesion in the pancreas, but an 111In-pentetreotide SPECT/CT scan performed after a similar episode four weeks later showed increased focal uptake at the head of the pancreas. The results of a selective arterial calcium injection test were negative. After careful consideration and discussion among colleagues, surgical intervention was selected, and a pancreaticoduodenectomy was performed. On histology, there were elevated numbers of Langerhans islets in the pancreatic head, and the islets themselves appeared enlarged. Hypertrophic β-cells comprised the majority, but α-cells, δ-cells and pancreatic polypeptide were also detected in the islets. Based on the histopathological results and repeated hyperinsulinemic hypoglycemic crises, the patient was finally diagnosed with adult-onset nesidioblastosis. He had no hypoglycemic symptoms during outpatient follow-up examination. Since 111In-pentetreotide SPECT/CT may be able to detect nesidioblastosis, clinicians should consider this relatively new-modality examination when encountering such cases.
Keywords 111In-pentetreotide nesidioblastosis single-photon emission computed tomography hyperinsulinemic hypoglycemia
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-10
Volume volume78
Issue issue5
Publisher Okayama University Medical School
Start Page 423
End Page 428
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39467661
Web of Science KeyUT 001343346400009
JaLCDOI 10.18926/AMO/67664
FullText URL 78_5_401.pdf
Author Toyota, Yusuke| Uda, Kazuhiro| Shirabe, Komei| Moriwake, Tadashi|
Abstract Severe febrile thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease that is endemic in parts of eastern Asia. Few pediatric cases have been reported. We describe a case of SFTS in a seven-year-old girl who presented with prolonged fever and gastrointestinal symptoms. Leukopenia and thrombocytopenia on hematology, and a history of outdoor activity led us to diagnose SFTS, although the patient had no tick bite marks. We also review the literature and discuss the characteristics of pediatric SFTS. Physicians should consider SFTS in the differential diagnosis of fever with thrombocytopenia in children living in endemic areas.
Keywords child tick-borne disease severe febrile thrombocytopenia syndrome zoonoses
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-10
Volume volume78
Issue issue5
Publisher Okayama University Medical School
Start Page 401
End Page 405
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39467658
JaLCDOI 10.18926/AMO/67657
FullText URL 78_5_371.pdf
Author Gotoh, Kazuyoshi| Miyoshi, Makoto| I Putu Bayu Mayura| Tsuji, Shuma| Iio, Koji| Fukushima, Shinnosuke| Matsushita, Osamu| Hagiya, Hideharu|
Abstract Spread of carbapenemase-producing Enterobacterales (CPE) is an ongoing public health issue worldwide, including in Japan. In this study, we investigated the phenotypic and genetic characteristics of CPE isolates at Okayama University Hospital over the 5 years (2013-2018) prior to the outbreak of the 2019 coronavirus pandemic. Of 24 carbapenem-resistant Enterobacterales isolated during the study period, we identified 8 CPE isolates harboring blaIMP-1 (5 isolates) and blaIMP-6 genes (3 isolates). Bacterial species and carbapenem susceptibility patterns exhibited diversity. Minimum inhibitory concentrations (MICs) of meropenem were generally higher than those of imipenem and biapenem. Results of pulsed-field gel electrophoresis demonstrated that neither clonal nor plasmid-mediated outbreaks of blaIMP-harboring CPE isolates have developed at our hospital. One Klebsiella oxytoca isolate showed a high MIC (128 μg/mL) of meropenem, which could be explained by the high plasmid copy number. Subsequent analysis of this isolate may elucidate the intricacies of carbapenem resistance profiles among CPE isolates. Collectively, our findings underscore the necessity for ongoing genetic surveillance of CPE, complemented by tailored approaches for infection prevention and control.
Keywords antimicrobial resistance carbapenemase-producing enterobacterales carbapenemase-resistant enterobacterales Silent pandemic whole genome sequence
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-10
Volume volume78
Issue issue5
Publisher Okayama University Medical School
Start Page 371
End Page 376
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39467655
Web of Science KeyUT 001343346400003
JaLCDOI 10.18926/AMO/67656
FullText URL 78_5_363.pdf
Author Takanaga, Satoe| Matsumoto, Naomi| Kadowaki, Tomoka| Takao, Soshi| Yorifuji, Takashi|
Abstract Kawasaki disease (KD) is a pediatric disease of unknown etiology that commonly affects infants in East Asia. Infants born small for gestational age (SGA) have weaker immune systems and are more susceptible to infection. Using data from a nationwide Japanese birth cohort study conducted in 2010 (n=34,579), we investigated whether SGA increases the risk of KD. SGA was defined as birth weight below the 10th percentile for gestational age. The outcome was hospitalization for KD between 6 and 30 months of age. The association between SGA and hospitalization for KD, adjusted for child and maternal factors, was examined using logistic regression. Of the 231 children hospitalized for KD, 9.5% were SGA. Further statistical analysis showed that SGA did not increase the odds ratio (OR) of hospitalization for KD (adjusted OR 1.12, 95% confidence interval 0.71-1.75). This result was not changed with stratification by early daycare attendance and preterm status. Reasons for the lack of association may include the multifactorial pathogenesis of KD; in addition, the types of infections to which SGA infants are predisposed may differ from those triggering KD. Overall, our large nationwide study found no association between SGA and KD.
Keywords Kawasaki disease (KD) small for gestational age (SGA) cohort epidemiology
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-10
Volume volume78
Issue issue5
Publisher Okayama University Medical School
Start Page 363
End Page 370
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39467654
JaLCDOI 10.18926/AMO/67655
FullText URL 78_5_357.pdf
Author Yamawaki, Ryoko| Oda, Yoshiaki| Yamane, Shuhei| Uotani, Koji| Misawa, Haruo| Katayama, Yoshimi| Hamada, Masanori| Ozaki, Toshifumi|
Abstract Research on postural control in patients with adolescent idiopathic scoliosis (AIS) has focused on static postural control, with few studies assessing dynamic postural control. We aimed to identify factors affecting index of postural stability (IPS), a dynamic postural control parameter, in patients with AIS. The participants comprised 50 female patients with AIS. We measured the IPS using stabilometry to evaluate dynamic postural control ability. We investigated age of the participants, major curve position (thoracic or thoracolumbar/lumbar), Cobb angle, and coronal balance. We then assessed the relationships between stabilometry parameters and other variables. IPS was analyzed with a linear regression model. Coronal balance, major curve position, and age each correlated with dynamic postural control ability. The Cobb angle showed no correlation with any of the parameters. Our results offer new insights into the assessment of postural control in patients with AIS.
Keywords adolescent idiopathic scoliosis postural control coronal balance index of postural stability stabilometry
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2024-10
Volume volume78
Issue issue5
Publisher Okayama University Medical School
Start Page 357
End Page 362
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39467653
Web of Science KeyUT 001343346400001
FullText URL fulltext.pdf
Author Hirata, Shoichiro| Hamada, Kenta| Iwamuro, Masaya| Mouri, Hirokazu| Miyahara, Koji| Tsuzuki, Takao| Yamauchi, Kenji| Kobayashi, Sayo| Takahashi, Sakuma| Takenaka, Ryuta| Hori, Shinichiro| Inoue, Masafumi| Toyokawa, Tatsuya| Nishimura, Mamoru| Ishiyama, Shuhei| Miyaike, Jiro| Kato, Ryo| Matsubara, Minoru| Yunoki, Naoko| Kanzaki, Hiromitsu| Kawahara, Yoshiro| Okada, Hiroyuki| Ishikawa, Hideki| Otsuka, Motoyuki| Okayama Gut Study Group|
Keywords direct oral anticoagulants endoscopic submucosal dissection gastric cancer postprocedural bleeding warfarin
Published Date 2024-10-03
Publication Title Journal of Gastroenterology and Hepatology
Volume volume39
Issue issue12
Publisher Wiley
Start Page 2760
End Page 2766
ISSN 0815-9319
NCID AA10727383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Author(s).
File Version publisher
PubMed ID 39363400
DOI 10.1111/jgh.16757
Web of Science KeyUT 001328472100001
Related Url isVersionOf https://doi.org/10.1111/jgh.16757
FullText URL fulltext.pdf
Author Fujii, Yuki| Uchida, Daisuke| Sato, Ryosuke| Obata, Taisuke| Akihiro, Matsumi| Miyamoto, Kazuya| Morimoto, Kosaku| Terasawa, Hiroyuki| Yamazaki, Tatsuhiro| Matsumoto, Kazuyuki| Horiguchi, Shigeru| Tsutsumi, Koichiro| Kato, Hironari| Inoue, Hirofumi| Cho, Ten| Tanimoto, Takayoshi| Ohto, Akimitsu| Kawahara, Yoshiro| Otsuka, Motoyuki|
Note The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-72312-3|
Published Date 2024-09-28
Publication Title Scientific Reports
Volume volume14
Issue issue1
Publisher Nature Portfolio
Start Page 22441
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2024
File Version publisher
PubMed ID 39341885
DOI 10.1038/s41598-024-72312-3
Web of Science KeyUT 001325241700059
Related Url isVersionOf https://doi.org/10.1038/s41598-024-72312-3
FullText URL fulltext20240907-01.pdf fig20240907-01.pdf
Author Nakamura, Naoki| Makimoto, Go| Tanaka, Takaaki| Kato, Yuka| Oze, Isao| Kozuki, Toshiyuki| Yokoyama, Toshihide| Ichikawa, Hirohisa| Kuyama, Shoichi| Hara, Naofumi| Maeda, Yoshinobu| Hotta, Katsuyuki|
Keywords Kampo CIPN prophylaxis neuropathy taxane
Note © 2024 The Japanese Respiratory Society. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Aug. 2025.|
Published Date 2024-09
Publication Title Respiratory Investigation
Volume volume62
Issue issue5
Publisher Elsevier BV
Start Page 897
End Page 900
ISSN 2212-5345
NCID AA12579673
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2024 The Japanese Respiratory Society.
File Version author
PubMed ID 39182943
DOI 10.1016/j.resinv.2024.07.017
Web of Science KeyUT 001292150300001
Related Url isVersionOf https://doi.org/10.1016/j.resinv.2024.07.017
Title Alternative The 2023 Incentive Award of the Okayama Medical Association in Cancer Research (2023 Hayashibara Prize and Yamada Prize)
Author Ishino, Takamasa|
Publication Title Journal of Okayama Medical Association
Published Date 2024-08-01
Volume volume136
Issue issue2
Start Page 45
End Page 47
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.136.45
language Japanese
Copyright Holders Copyright (c) 2024 岡山医学会
File Version publisher
DOI 10.4044/joma.136.45
JaLCDOI 10.18926/AMO/67553
FullText URL 78_4_345.pdf
Author Kato, Gentaro| Narumiya, Yuto| Okuyama, Michihiro| Shimizu, Shuji| Sangawa, Kenji| Yamamoto, Shu|
Abstract The presence of an intraperitoneal source of infection, e.g., a liver abscess, can be an obstacle to performing an abdominal aortic surgery with a midline laparotomy because graft infection is one of the most critical complications of aortic surgery. We report the successful Y-grafting of a pararenal abdominal aortic aneurysm through a retroperitoneal approach in a 67-year-old male undergoing liver abscess drainage. The retroperitoneal approach to the abdominal aorta may be useful for abdominal aortic surgery in patients with a localized intraperitoneal infection.
Keywords blunt liver trauma liver abscess abdominal aortic aneurysm Y-grafting retroperitoneal approach
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2024-08
Volume volume78
Issue issue4
Publisher Okayama University Medical School
Start Page 345
End Page 347
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2024 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 39198989
Web of Science KeyUT 001310557400003