start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=6 article-no= start-page=24-00129 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=2024 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of artificial defect on tensile properties of thin titanium alloy wire en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study investigated the effects of artificial defects, introduced via focused ion beam (FIB) processing, on the tensile properties of thin titanium alloy wires (Ti-6Al-4V). Results indicated that the defective wires fractured when the net-section nominal stress reached the ultimate tensile strength of the smooth wires, probably because of localized stress concentrations relaxing due to plastic deformation around the defects. The effect of defects on tensile properties was classified into three regions based on the size of the defect area. In the case of small defects, wires fractured at the smooth area away from the defects where the cross-sectional strength was lower. In this case, the defects minimally affected the tensile properties. This is attributable to variations in the cross-sectional strength of the wire, which resulted in some sections with lower strength as compared with the defect area. In the case of medium-sized defects, the fracture strain decreased gradually as the defect area increased. Finally, in the case of large defects, the fracture strain was extremely small. The boundary between the medium-sized and large defects indicates the transition from plastic deformation to no plastic deformation in the smooth area. en-copyright= kn-copyright= en-aut-name=SAKAMOTOJunji en-aut-sei=SAKAMOTO en-aut-mei=Junji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TADANaoya en-aut-sei=TADA en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UEMORITakeshi en-aut-sei=UEMORI en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OISHIKoyo en-aut-sei=OISHI en-aut-mei=Koyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Okayama University kn-affil= affil-num=2 en-affil=Okayama University kn-affil= affil-num=3 en-affil=Okayama University kn-affil= affil-num=4 en-affil=Okayama University kn-affil= en-keyword=Ti-6Al-4V kn-keyword=Ti-6Al-4V en-keyword=Thin wire kn-keyword=Thin wire en-keyword=Tensile properties kn-keyword=Tensile properties en-keyword=Defect kn-keyword=Defect en-keyword=Focused ion beam kn-keyword=Focused ion beam en-keyword=Net-section nominal stress kn-keyword=Net-section nominal stress en-keyword=Fracture surface kn-keyword=Fracture surface en-keyword=Fracture strain kn-keyword=Fracture strain END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190329 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Newsletter from Course for Prospective Museum Workers, Faculty of Letters, Okayama University kn-title=学芸員課程 Newsletter 第12号 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=光本順 kn-aut-sei=光本 kn-aut-mei=順 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=鈴木恒志 kn-aut-sei=鈴木 kn-aut-mei=恒志 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=木下莉沙 kn-aut-sei=木下 kn-aut-mei=莉沙 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=黒木恵那 kn-aut-sei=黒木 kn-aut-mei=恵那 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田絢音 kn-aut-sei=多田 kn-aut-mei=絢音 aut-affil-num=5 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小野田澪 kn-aut-sei=小野田 kn-aut-mei=澪 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=文学部 affil-num=2 en-affil= kn-affil=文学部 哲学芸術学専修コース affil-num=3 en-affil= kn-affil=文学部 地理学・社会学・文化人類学・社会文化学分野 affil-num=4 en-affil= kn-affil=文学部 歴史学・考古学分野 affil-num=5 en-affil= kn-affil=文学部 芸術学・美術史分野 affil-num=6 en-affil= kn-affil=文学部 歴史学・考古学分野 END start-ver=1.4 cd-journal=joma no-vol=153 cd-vols= no-issue= article-no= start-page=107623 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prediction of slip activity of crystal grains around semi-circular and semi-elliptical notches in thin-sheet specimens of pure titanium using formulated macroscopic stress distribution and crystal orientation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Thin metal sheets and wires are important materials for various devices used in electrical, mechanical, and medical fields. With the downsizing of these devices, demand for thinner sheets and wires has increased. Amongst the many metals available, pure titanium has been attracting much attention for use in medical and dental devices because of its good biocompatibility in addition to its light weight and high corrosion resistance. However, thin metal sheets and wires are usually polycrystalline materials and, with the downsizing of materials, there is a loss of homogeneity during deformations. Inhomogeneous deformation becomes significant in thin sheets and wires, owing to the different crystal orientations and geometries of crystal grains. Furthermore, the shapes of such devices are not uniform, unlike, say, a simple rod. Therefore, macroscopic stress and strain concentrations should be taken into consideration when designing these devices as they affect the localization of deformation and the resultant fracture. In this study, semi-circular and semi-elliptical notched specimens made of thin-sheet polycrystalline pure titanium are subjected to tensile testing. Inhomogeneous deformation caused by crystallographic slip is observed near the notch root. Analysis of the crystal orientation and observation of the slip line show that the slip initiation in crystal grains is affected by the macroscopic stress distribution and can be predicted from the slip activity calculated from both the critical resolved shear stress on the slip systems and the resolved shear stress acting on prospective slip planes obtained from the macroscopic multiaxial stress distribution. en-copyright= kn-copyright= en-aut-name=TadaNaoya en-aut-sei=Tada en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UemoriTakeshi en-aut-sei=Uemori en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakamotoJunji en-aut-sei=Sakamoto en-aut-mei=Junji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Mechanical engineering kn-keyword=Mechanical engineering en-keyword=Microdevices made of thin metal sheet kn-keyword=Microdevices made of thin metal sheet en-keyword=Pure titanium kn-keyword=Pure titanium en-keyword=Deformation kn-keyword=Deformation en-keyword=Microscopic characterization and microanalysis kn-keyword=Microscopic characterization and microanalysis en-keyword=Plastic deformation kn-keyword=Plastic deformation en-keyword=Microscopic inhomogeneity and stress kn-keyword=Microscopic inhomogeneity and stress en-keyword=concentration kn-keyword=concentration en-keyword=Slip activity control kn-keyword=Slip activity control END start-ver=1.4 cd-journal=joma no-vol=143 cd-vols= no-issue=2 article-no= start-page=021502 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=2020105 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prediction of the Fracture Location by Tensile Tests of Gray Cast Iron Based on the Dimensional Changes of Graphite Flakes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Gray cast iron has been used as a component in various mechanical parts, such as the blocks and heads of automobile and marine engines, cylinder liners for internal combustion engines, and machine tool bases. It is desirable because of its good castability and machinability, damping characteristics, and high performance-to-cost ratio. On the other hand, weak graphite flakes present in gray cast iron serve as stress concentrators and adversely affect the material strength. Therefore, it is crucial to examine the relationship between the distribution of graphite flakes and the strength or fracture of gray cast iron. In this study, tensile tests on gray cast iron were carried out using a plate specimen and observed by scanning electron microscopy, and the microscopic deformation was observed on the specimen surface. Particularly, the change in the size of graphite flakes during the tensile tests was examined, and the observed trend was discussed. The experimental results reveal that the dimensional changes in the graphite flakes vary in the observed area and that the final fracture occurs in an area where a large dimensional change is observed, suggesting that the fracture location or critical parts of gray cast iron can be predicted from the dimensional changes of the graphite flakes at an early stage of deformation. en-copyright= kn-copyright= en-aut-name=TadaNaoya en-aut-sei=Tada en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UemoriTakeshi en-aut-sei=Uemori en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakamotoJunji en-aut-sei=Sakamoto en-aut-mei=Junji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=14 article-no= start-page=4883 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200716 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Finite Element Study of the Effect of Internal Cracks on Surface Profile Change due to Low Loading of Turbine Blade en-subtitle= kn-subtitle= en-abstract= kn-abstract=Turbine blades for thermal power plants are exposed to severe environments, making it necessary to ensure safety against damage, such as crack formation. A previous method detected internal cracks by applying a small load to a target member. Changes in the surface properties of the material were detected before and after the load using a digital holographic microscope and a digital height correlation method. In this study, this technique was applied in combination with finite element analysis using a 2D and 3D model simulating the turbine blades. Analysis clarified that the change in the surface properties under a small load varied according to the presence or absence of a crack, and elucidated the strain distribution that caused the difference in the change. In addition, analyses of the 2D model considering the material anisotropy and thermal barrier coating were conducted. The difference in the change in the surface properties and strain distribution according to the presence or absence of cracks was elucidated. The difference in the change in the top surface height distribution of the materials with and without a crack was directly proportional to the crack length. As the value was large with respect to the vertical resolution of 0.2 nm of the digital holographic microscope, the change could be detected by the microscope. en-copyright= kn-copyright= en-aut-name=SakamotoJunji en-aut-sei=Sakamoto en-aut-mei=Junji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TadaNaoya en-aut-sei=Tada en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UemoriTakeshi en-aut-sei=Uemori en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KuniyasuHayato en-aut-sei=Kuniyasu en-aut-mei=Hayato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Shimadzu Corporation kn-affil= en-keyword=nondestructive inspection kn-keyword=nondestructive inspection en-keyword=crack detection kn-keyword=crack detection en-keyword=low loading kn-keyword=low loading en-keyword=surface profile kn-keyword=surface profile en-keyword=turbine blade kn-keyword=turbine blade en-keyword=finite element analysis kn-keyword=finite element analysis END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=7 article-no= start-page=783 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of Lubrication and Forging Load on Surface Roughness, Residual Stress, and Deformation of Cold Forging Tools en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cold forging is a metal forming that which uses localized compressive force at room temperature. During the cold forging process, the tool is subjected to extremely high loads and abrasive wear. Lubrication plays an important role in cold forging to improve product quality and tool life by preventing direct metallic contact. Surface roughness and residual stress also greatly affects the service life of a tool. In this study, variations in surface roughness, residual stress, and specimen deformation with the number of cold forging cycles were investigated under different forging conditions. Specimens that were made of heat-treated SKH51 (59-61 HRC), a high-speed tool steel with a polished working surface, were used. The specimens were subjected to an upsetting process. Compressive residual stress, surface roughness, and specimen deformation showed a positive relationship with the number of forging cycles up to a certain limit and became almost constant in most of the forging conditions. A larger change in residual stress and surface roughness was observed at the center of the specimens in all the forging conditions. The effect of the magnitude of the forging load on the above discussed parameters is large when compared to the effect of the lubrication conditions. en-copyright= kn-copyright= en-aut-name=KarunathilakaNuwan en-aut-sei=Karunathilaka en-aut-mei=Nuwan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TadaNaoya en-aut-sei=Tada en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UemoriTakeshi en-aut-sei=Uemori en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HanamitsuRyota en-aut-sei=Hanamitsu en-aut-mei=Ryota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FujiiMasahiro en-aut-sei=Fujii en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OmiyaYuya en-aut-sei=Omiya en-aut-mei=Yuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawanoMasahiro en-aut-sei=Kawano en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=7 en-affil=Zeno Tech Co., Ltd kn-affil= en-keyword=cold forging kn-keyword=cold forging en-keyword=high-speed tool steel kn-keyword=high-speed tool steel en-keyword=lubrication kn-keyword=lubrication en-keyword=residual stress kn-keyword=residual stress en-keyword=surface roughness kn-keyword=surface roughness en-keyword=tool deformation kn-keyword=tool deformation END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20141231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=菌状息肉症の皮膚病性リンパ節腫脹において、DC-LAMP陽性の成熟樹状細胞が増加している kn-title=Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TadaKotaro en-aut-sei=Tada en-aut-mei=Kotaro kn-aut-name=多田光太郎 kn-aut-sei=多田 kn-aut-mei=光太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=129 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Antibacterial efficacy of photocatalytic reaction on titanium dioxide-coated ceramic air filters kn-title=酸化チタン担持セラミックフィルターの光触媒反応による抗菌効果の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Titanium dioxide (TiO2) photocatalysis generates reactive oxygen species such as ・OH and ・O2-, which can effectively eliminate organic compounds. In the present study, we evaluated the antibacterial and antifungal effects of TiO2-coated ceramic air filters in both laboratory and hospital settings. Photocatalysis with the TiO2-coated ceramic filter effectively inactivated all 4 pathogenic organisms tested. Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. After the photocatalysis reaction for 4 h under UV-A (365nm, 250μW/?) irradiation, the percentage reductions of the number of E. coli, P. aeruginosa, S. aureus, C. albicans cells were 99.9%, 98.9%, 97.7% and 99.9%, respectively, indicating that Gram-negative bacteria are more susceptible to such photocatalysis than Gram-positive bacteria. Scanning electron microscopic analysis showed damage to the cytoplasmic membrane and cell wall by photocatalysis : consistent with above observations, the morphological change of Gram-negative E. coli was greater than that of Gram-positive S. aureus. 　Further, an air cleaner equipped with a TiO2-coated ceramic filter significantly decreased the number of bacteria floating in hospitals. 　These results indicate that air cleaners with TiO2-coated ceramic filters could be useful in reducing the incidence of nosocomial infections. en-copyright= kn-copyright= en-aut-name=NakaoMiyuki en-aut-sei=Nakao en-aut-mei=Miyuki kn-aut-name=中尾美幸 kn-aut-sei=中尾 kn-aut-mei=美幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　病原細菌学 en-keyword=光触媒（photocatalysis） kn-keyword=光触媒（photocatalysis） en-keyword=酸化チタン担持セラミックフィルター（TiO2-coated ceramic air filters） kn-keyword=酸化チタン担持セラミックフィルター（TiO2-coated ceramic air filters） en-keyword=抗菌効果（antimicrobial effect） kn-keyword=抗菌効果（antimicrobial effect） en-keyword=院内感染（nosocomial infection） kn-keyword=院内感染（nosocomial infection） en-keyword=空気清浄機（air cleaner） kn-keyword=空気清浄機（air cleaner） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肺癌に対するラジオ波焼灼療法が呼吸機能に及ぼす影響 kn-title=Influence of Radiofrequency Ablation of Lung Cancer on Pulmonary Function en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TadaAkihiro en-aut-sei=Tada en-aut-mei=Akihiro kn-aut-name=多田明博 kn-aut-sei=多田 kn-aut-mei=明博 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=9 article-no= start-page=1827 end-page=1868 dt-received= dt-revised= dt-accepted= dt-pub-year=1928 dt-pub=19280930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ueber die Entwicklung und den Bau des Schistosomum japonicum im Endwirte kn-title=日本住血吸蟲ノ終宿主體内ニ於ケル發育及ビ其構造ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Verfasser benutzte als Versuchstiere M?use, f?hrte mit den Cercarien dieses W?rmchens den Infektionsversuch aus und studierte die Entwicklung des W?rmchens von gleich nach der Invasion an bis zum 38. Tage. Weiter wurde derselbe Versuch auch an Hunden vorgenommen. Am 55. Tage nach der Infektion wurden die geschlechtsreifen W?rmer aus dem Versuchshunde herausgenommen und n?her untersucht. Es ergab sich folgendes: 1. Die W?rmer entwickeln sich nach ihrer Ankunft in der Pfortader rapid. Bis zum zehnten Tage ist das M?nnchen gr?sser als das Weibchen. Darauf aber ?bertrifft das Weibchen an L?nge das M?nnchen, w?hrend das M?nnchen dicker und breiter als das Weibchen wird. Am 38. Tage zeigen die W?rmchen das Wachstumsmaximum, wenn man die Maus als Endwirt benutzt. 2. Die Gr?sse des geschlechtsreifen Tieres ist je nach der Art des Wirtes verschieden. 3. Die Giftdr?sen und der Kopfsack verschwinden in 48 Stunden. Vom 12. Tage an bildet sich der Canalis gyaecophorus des M?nnchens. 4. Die W?rmer besitzen auf der ganzen Oberfl?che Stacheln, die je nach ihrer Lage verschieden gestaltet sind. 5. Der Mundsaugnapf wird durch die Differenzierung der Meristemzellen im Vorderk?rperteile gebildet, indem im Vorderk?rperteil der Kopfsack, die Ausf?hrungsg?nge der Giftdr?sen, die Retraktoren, der R?ssel und die Grenzmembran verschwinden. 6. Die Entwicklung des Bauchsaugnapfes wie die des Mundsaugnapfes geht von den noch undifferenzierten Meristemzellen aus. 7. Ueber die Natur der sogenannten “grossen Zellen” ist anzunehmen, dass diese Zellen entweder im Laufe der Entwicklung oder nach Abschluss des Wachstums durch irgendeine Ursache degeneriert sind. 8. Die M?ndungsstelle des Mundh?hlenteils (Oesophagus anterior der Cercaria Takahashi.) wird nach 24 Stunden hufeisenf?rmig, und im Laufe der Entwicklung zeigt sie die Form eines Trichters, welcher nach aussen sich ?ffnet. Allm?hlich n?hert sich die Spitze des Trichters der Grenzmembran, indem sich der Mundh?hlenteil erweitert. Am 12. Tage ist die Mundh?hle fast g?nzlich ausgedildet. 9. Die Stacheln auf der inneren Fl?che der Mundh?hle entwickeln sich vom 3. Tage an. Verfasser sah als die eigentliche Mundh?hle die Mundh?hle in der N?he des Oesophagus an, wo die Stacheln fehlen. 10. Der gekr?mmte Oesophagus wird bei der Invasionsform im Laufe der weiteren Entwicklung ganz gerade, und vom 8. Tage an erweitert er sich vor der Nervencommissur. 11. Die k?rner?hnliche Substanz, welche sich auf der inneren Fl?che des Oesophagus bei der Invasionsform vorfindet und sich durch die Mallory'sche Methode rot tingiert, verliert am 4. Tage ihre F?rbbarkeit, und am 6. Tage bildet sich die innere Schicht, welche als Zottenartige Falte erscheint. 12. Die Speicheldr?sen werden durch die Differenzierung der blasenkernhaltigen Zellen ausgebildet, welche bei der Invasionsform um den hinterenteil (sp?ter den vorderen Teil) des Oesophagus herum und in der N?he des Darmes auftreten. 13. Die Darmschenkelanlage wird durch das Auftreten der blasenkernhaltigen Zellen in dem Parenchym hinter der Darmanlage immer deutlicher. Der Darmschenkel verl?ngert sich nach hinten durch das Hinzukommen der Darmbildungszellen, welche hinter der Darmschenkelanlage auftreten. Am 10. Tage vereinigen sich die beiden Darmschenkel bei 83% der W?rmer. 14. Verfasser stellte durch histologische Untersuchungen fest, dass es am 6. Tage zur Geschlechtsdifferenzierung kommt. 15. Das M?nnchen besitzt als Begattungsapparat einen Cirrus und zwei Protraktoren. 16. Die Einbuchtung am k?rperende, welche durch Abstossung des Schwanzes zustandekommt, zeigt R?hrenform und bildet den Exkretionsporus. Im Laufe der Entwicklung vermehren sich die feineren Aeste des Exkretionskanals und die Terminal-zellen. Die zwei Wimpersch?pfe im Exkretionskanal verschwinden in 8 Tagen. Vom 10. Tage an zeigen sich auf der inneren Fl?che des Kanals lebhaft schwingende Cilien. 17. Je 5 Nerven gehen von beiden Nervenzentren aus und zwar 3 nach vorn und 2 nach hinten. Alle vorderen 3 Nerven lassen sich bis zum vorderen Ende des Mundsaugnapfes verfolgen. Die hinteren 2 Nerven (R?cken- und Bauchnerv) treffen hinter dem Bauchsaugnapfe zusammen, und dieser vereinigt Nerv stimmt mit dem der anderen Seite hinter der Exkretionsblase ?berein. Ausserdem hat Verfasser in der H?he des Banchsaugnapfes einen Nerfenring bemerkt, welcher R?cken-und Baxuchnerv beider seiten miteinauder verbindet. 18. Verfasser fand, dass das Schistosomum Japonicum in der Haut eine gr?ssere Anzahl von Sinnesapparaten besitzt. 19. Der Parenchymmuskel entwickelt sich erst am 8. Tage. Der Parenchymmuskel scheint ein sog. "Hohlmuskel" zu sein und entwickeit sich beim M?nnchen st?rker als beim Weibchen. en-copyright= kn-copyright= en-aut-name=TadaShigeru en-aut-sei=Tada en-aut-mei=Shigeru kn-aut-name=多田繁 kn-aut-sei=多田 kn-aut-mei=繁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=8 article-no= start-page=1539 end-page=1574 dt-received= dt-revised= dt-accepted= dt-pub-year=1928 dt-pub=19280831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=日本住血吸蟲ノ終宿主體内ニ於ケル發育及ビ其構造ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田繁 kn-aut-sei=多田 kn-aut-mei=繁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學細菌學教室 END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=1 article-no= start-page=7 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=200112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Microscopic Observation of Tensile Deformation Behavior of Polycrystalline Titanium with Scanning Probe Microscope en-subtitle= kn-subtitle= en-abstract= kn-abstract=The change in the surface morphology of polycrystalline titanium during tensile plastic deformation is studied, using the scanning probe microscope as well as the laser scanning microscope. The observation shows that the slip occurs mainly near grain boundary at the strain range of ε < 0.05. The slip develops with the applied strain, and the slip on the second slip system or the crossing of slip lines appear. The surface roughness increases linearly with the applied strain. The height difference between the grain boundary area and the inner grain area also increases with the applied strain, though the increase rate becomes low after the applied strain of about 0.3. The nano-scale height difference of the surface step of slip lines increases with the applied strain, though it remains almost constant after the applied strain of 0.4. The averaged surface roughness measured with the scanning probe microscope is in good agreement with that measured with the laser scanning microscope. en-copyright= kn-copyright= en-aut-name=LiYan en-aut-sei=Li en-aut-mei=Yan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakeji en-aut-sei=Abe en-aut-mei=Takeji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TadaNaoya en-aut-sei=Tada en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KanazawaMasanori en-aut-sei=Kanazawa en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University en-keyword=Plasticity kn-keyword=Plasticity en-keyword=Polycrystalline Titanium kn-keyword=Polycrystalline Titanium en-keyword=Tensile Deformation kn-keyword=Tensile Deformation en-keyword=Surface Morphology kn-keyword=Surface Morphology en-keyword=Slip kn-keyword=Slip en-keyword=Twin kn-keyword=Twin en-keyword=Probe Scanning Microscope kn-keyword=Probe Scanning Microscope en-keyword=Laser Scanning Microscope kn-keyword=Laser Scanning Microscope END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=1 article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=200112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Observation of Orientation Change During Plastic Deformation of Polycrystalline Copper by EBSD Method en-subtitle= kn-subtitle= en-abstract= kn-abstract=Change in crystal orientation and strain of individual grains during tensile plastic deformation are studied to clarify on the microscopic deformation behavior of polycrystalline copper. The orientation of grain is measured by electron backscatter diffraction (EBSD) technique in the scanning electron microscope. The principal strain of grain is also measured by obtaining the approximated ellipse of strain distribution. The deformation of grains dependent on their initial orientation and the rotation of the principal strain during uniaxial tension are clarified. en-copyright= kn-copyright= en-aut-name=KondouRyouji en-aut-sei=Kondou en-aut-mei=Ryouji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakeji en-aut-sei=Abe en-aut-mei=Takeji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TadaNaoya en-aut-sei=Tada en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShimizuIchiro en-aut-sei=Shimizu en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=2 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=3 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=4 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University en-keyword=Polycrystalline Copper kn-keyword=Polycrystalline Copper en-keyword=Plastic Deformation kn-keyword=Plastic Deformation en-keyword=SEM kn-keyword=SEM en-keyword=EBSD Method kn-keyword=EBSD Method en-keyword=Grain Orientation kn-keyword=Grain Orientation en-keyword=Crystal Orientation Map kn-keyword=Crystal Orientation Map END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=133 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A surgical case of phlegmonous gastritis after endoscopic submucosal dissection for early gastric cancer kn-title=早期胃癌に対する内視鏡的粘膜下層剥離術後に 急性胃蜂窩織炎を併発した１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Phlegmonous gastritis is a rare inflammatory lesion in which bacterial infection occurs in the gastric wall. A 92-year-old man was admitted to the medical ward due to early gastric cancer. The patient received endoscopic submucosal dissection (ESD), and he complained of sudden-onset upper abdominal pain the day after ESD. On physical examination he showed rebound tenderness in the upper abdomen. The white blood cell count was 16,100/μl, and an abdominal CT-SCAN showed diffuse and irregular thickening of the gastric wall. At emergency operation, a subtotal gastrectomy was performed, and the patient had an uneventful recovery. en-copyright= kn-copyright= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=1 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=2 ORCID= en-aut-name=HamanoRyousuke en-aut-sei=Hamano en-aut-mei=Ryousuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=3 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=4 ORCID= en-aut-name=TunemitsuYousuke en-aut-sei=Tunemitsu en-aut-mei=Yousuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=5 ORCID= en-aut-name=OotsukaShinya en-aut-sei=Ootsuka en-aut-mei=Shinya kn-aut-name=大塚真哉 kn-aut-sei=大塚 kn-aut-mei=真哉 aut-affil-num=6 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=7 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=8 ORCID= en-aut-name=GoubaruTomohiro en-aut-sei=Goubaru en-aut-mei=Tomohiro kn-aut-name=合原大博 kn-aut-sei=合原 kn-aut-mei=大博 aut-affil-num=9 ORCID= en-aut-name=FujitaIsao en-aut-sei=Fujita en-aut-mei=Isao kn-aut-name=藤田勲生 kn-aut-sei=藤田 kn-aut-mei=勲生 aut-affil-num=10 ORCID= en-aut-name=MurakamiTakako en-aut-sei=Murakami en-aut-mei=Takako kn-aut-name=村上敬子 kn-aut-sei=村上 kn-aut-mei=敬子 aut-affil-num=11 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=友田純 kn-aut-sei=友田 kn-aut-mei=純 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=10 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=11 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=12 en-affil= kn-affil=国立病院機構福山医療センター　内科 en-keyword=急性胃蜂窩織炎 (phlegmonous gastritis) kn-keyword=急性胃蜂窩織炎 (phlegmonous gastritis) en-keyword=内視鏡的粘膜下層剥離術 (endoscopic submucosal dissection：ESD) kn-keyword=内視鏡的粘膜下層剥離術 (endoscopic submucosal dissection：ESD) END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue=6 article-no= start-page=1471 end-page=1480 dt-received= dt-revised= dt-accepted= dt-pub-year=1940 dt-pub=19400630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die gerichtsmedizinische Bedeutung des Chlorgehaltes des verletzten Muskels kn-title=創傷部組織ニ於ケル鹽素量ノ法醫學的意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Unter verschiedenen Bedingungen hat Verfasser den Chlorgehalt des verletzten Meerschweinchenmuskels nach Mohr bestimmt. Die Ergebnisse k?nnen wie folgt zusammengetasst werden Der Chlorgehalt des verletzten Muskels bei lebenden Meerschweinchen ist gr?sser als der bei Meerschweinchenleichen. Dieser Unterschied zeigt sich 24 Stunden oder vielleicht noch l?nger nach dem Tod, was als chemische Hilfsmethode in den Vitalreaktionen bei der Verletzung ausgewertet werden k?nnte. en-copyright= kn-copyright= en-aut-name=TadakumaTateo en-aut-sei=Tadakuma en-aut-mei=Tateo kn-aut-name=多田隈建雄 kn-aut-sei=多田隈 kn-aut-mei=建雄 aut-affil-num=1 ORCID= en-aut-name=IrieTsunehisa en-aut-sei=Irie en-aut-mei=Tsunehisa kn-aut-name=入江恒久 kn-aut-sei=入江 kn-aut-mei=恒久 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學法醫學教室 affil-num=2 en-affil= kn-affil=岡山醫科大學法醫學教室 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=6-1 article-no= start-page=2857 end-page=2868 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistical Survy on Resection in Pulmonary Tuberculosis Part III. On the Main Complications kn-title=結核肺切除の統計的観察 第3編 主要な合併症について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Statistical survey in 1332 cases of pulmonary resections, eight years since 1949. was pesformed on the complications such as bronchial fistula, empyema and exacerbation. Those retes were 8.4 per cent in bronchial firtula (two per cent in peripheral), 2.5 per cent in empyema except for the pre-existing, and 3.1 per cent in exacerbation within six months after operation, in which 86 per cent was within two months. These complications showd a similar diagrammatic curve in the annual occurrences. noticeably high in the fore period and lowest in the later, coming up slightly in afterwards. Postoperative complications were intimately related to the operative indicetion selected, i. e. preoperative chemotherapy. Occurrences in postoperative complications were mainly decided by presence of positive bacilli in sputa and cavity, further presence of resistant bacilli. The rate was higher in case of presenting becilli in sputum from the cavity even after a long duration of chemotherapy and in case of developing resistant bacilli. These complications wese controlled in most cases, by adequate treatment in the early postoperative course. en-copyright= kn-copyright= en-aut-name=TadaKunio en-aut-sei=Tada en-aut-mei=Kunio kn-aut-name=多田邦夫 kn-aut-sei=多田 kn-aut-mei=邦夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立療養所山陽荘 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=6-1 article-no= start-page=2843 end-page=2856 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistical Survy on Resection in Pulmonary Tuberculosis Part II. On the Mode of Operation and the Result, and on Some Complications kn-title=結核肺切除の統計的観察 第2編 手術様式，一部合併症，成績等について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Pulmonary resection for tuberculosis in this Sanatorium, from 1957, was remarkably changed in its method and mode, directing to a destination of preserving pulmonary function. Sincc the postoperative treatment for pulmonary resection was improved, complications such as hemothorax and incomplete pulmonary expansion were decreased, 7.9 per cent in incomplete expansion. Mortality, 2.7 per cent as a whole, was also decreased due to reduction in exacerbation of pulmonary tuberculosis and other tuberculous comrplications. The rate of bacilli negative was 87.7 per cent, 96.3 per cent when transitory positive cases which became negative for over six months afterwarde were turned to negative rate. As a whole, over ninety-three per cont of all cases were operated on successfully, attaining the level of that in the other general surgery. en-copyright= kn-copyright= en-aut-name=TadaKunio en-aut-sei=Tada en-aut-mei=Kunio kn-aut-name=多田邦夫 kn-aut-sei=多田 kn-aut-mei=邦夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立療養所山陽荘 END start-ver=1.4 cd-journal=joma no-vol=71 cd-vols= no-issue=6-1 article-no= start-page=2833 end-page=2841 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=19590501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Statistical Survy on Resection in Pulmonary Tuberculosis Part I. On the Indication kn-title=結核肺切除の統計的観察 第1編 主として適応症について en-subtitle= kn-subtitle= en-abstract= kn-abstract=A chronological survey was done on the operation for pulmonary tuberculosis in 1353 cases admitted to this Sanatorium, from April 1949 to March 1947. The cases formerly indicated for thoracoplasty were mostly undergone pulmonary resections. Annual changes were not seen in sex, but ago distribution, tended to shift from younger to older. Preoperative condition of the patient was gradually improved, and reached to its limit recently. The condition roentgenological was improved annually, though, almost one half of the cases had cavities which were less expected to being improved by chemotherapy. The positive cases of tuberculous bacilli in sputa were getting decreased in number, without any expectations for improving by subsequent ohemotherapy. By the way, occurrence of resistant bacilli was increased in a sense. Duration from onset to operation was increase. Preoperative chemotherapy was shifted use of streptomycin, PAS and INAH instead of single use, and the dosage and duration were tended to increase. en-copyright= kn-copyright= en-aut-name=TadaKunio en-aut-sei=Tada en-aut-mei=Kunio kn-aut-name=多田邦夫 kn-aut-sei=多田 kn-aut-mei=邦夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=国立療養所山陽荘 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=11-12 article-no= start-page=1299 end-page=1307 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Chemosensitivity test using subrenal capsule assays Part 2. Clinical evaluation in fresh human lung cancer kn-title=Subrenal capsule assay法による制癌剤感受性試験に関する研究 第2編 肺癌臨床材料を用いたSubrenal capsule assay法の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical evaluation of a new chemosensitivity test using a subrenal capsule assay was performed. Chemosensitivity testing by SRC was performed on 28 fresh human lung cancer tissue samples. Eight of 10 cases were evaluable in squamous cell carcinoma, 3 of 11 in adenocarcinoma, 3 of 5 in small cell carcinoma, and 0 of 2 in other lung cancers. The factors affecting the evaluable assay rate were the abundance of cancer cells in tumor specimens and the tumor histological type. More cases of squamous cell carcinoma and small cell carcinoma were evaluable than of adenocarcinoma. In evaluable cases, tumor volume regression over 50% was seen in 4 of 14 assays using CDDP, 3 of 12 with CPA, and 6 of 11 with ADM. Regression over 70% was seen in 3 of 14 with CDDP, 1 of 12 with CPA, and 1 of 11 with ADM. In the drug-treated groups, tumor regression rates and histological effects were only weakly correlated. en-copyright= kn-copyright= en-aut-name=TadaAtsuhiko en-aut-sei=Tada en-aut-mei=Atsuhiko kn-aut-name=多田敦彦 kn-aut-sei=多田 kn-aut-mei=敦彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Subrenal capsule assay法 kn-keyword=Subrenal capsule assay法 en-keyword=制癌剤感受性試験 kn-keyword=制癌剤感受性試験 en-keyword=肺癌 kn-keyword=肺癌 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=11-12 article-no= start-page=1287 end-page=1297 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Chemosensitivity test using subrenal capsule assays Part 1. Experimental evaluation kn-title=Subrenal capsule assay法による制癌剤感受性試験に関する研究 第1編 Subrenal capsule assay法の基礎的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Experimental evaluation of a new chemosensitivity test using a subrenal capsule assays (SRC) was performed. The effects of various immunosuppressants-cyclosporin A (CSA), cyclophosphamide, whole body irradiation, and Bredinin were studied using human small cell lung cancer cell line (SBC-3) serially transplanted in nude mice. A significant degree of host cell infiltration was seen in tumor fragments implanted under the renal capsule of immunocompetent mice. However, treatment with immunosuppressants effectively suppressed the host immune reaction. The most effective immunosuppressant was CSA at 60mg/kg. We compared the antitumor activities of CDDP, MMC, VP-16, ADM, CPA, and VCR against SBC-3 using SRC and clonogenic assays. SRC was performed using mice administered CSA 60mg/kg. Chemotherapeutic agents (1/2 LD(10)) were administered on day 1 and antitumor activities were evaluated on day 6 after implantation. The results of the assays were well-correlated except with VCR. en-copyright= kn-copyright= en-aut-name=TadaAtsuhiko en-aut-sei=Tada en-aut-mei=Atsuhiko kn-aut-name=多田敦彦 kn-aut-sei=多田 kn-aut-mei=敦彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Subrenal capsule assay法 kn-keyword=Subrenal capsule assay法 en-keyword=制癌剤感受性試験 kn-keyword=制癌剤感受性試験 en-keyword=ヒト肺小細胞癌株 kn-keyword=ヒト肺小細胞癌株 END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=9-10 article-no= start-page=1043 end-page=1050 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cross-reactivity of chironomid midge antigens in patients with bronchial asthma kn-title=ユスリカ喘息における交差反応性の検討―オオユスリカ，アカムシユスリカ，セスジユスリカの比較検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to better understand the characteristics of bronchial asthma caused by chironomid midges, cross-reactivity of midges was examined in 163 asthmatics through observation of skin reactions and specific IgE and histamine release. Positive skin reactions were observed in 17 of 73 asthmatics (23.3%) for Chironomus plumosus, 89 of 276 (32.2%) of those for Tokunagayusurika akamusi, and 33 of 128 (25.8%) of those for Chironomus yoshimatsui. Two cases of 32 (6.3%) asthmatics for Chironomus plumosus, 16 of 144 (11.1%) of those for Tokunagayusurika akamusi, and 7 of 77 (9.1%) of those for Chironomus yoshimatsui showed a significant amount of histamine release (more than 15%). Cross-reactivity was present for Chironomus plumosus, Tokunagayusurika akamusi, Chironomus yoshimatsui, by both skin tests and basophil histamine release. It is suggested that both the male and female of Chironomus plumosus have common antigenecity, and cross-reactivity was observed between them. en-copyright= kn-copyright= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=3 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= en-aut-name=TakahashiHisaho en-aut-sei=Takahashi en-aut-mei=Hisaho kn-aut-name=高橋寿保 kn-aut-sei=高橋 kn-aut-mei=寿保 aut-affil-num=6 ORCID= en-aut-name=TadaSinya en-aut-sei=Tada en-aut-mei=Sinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= en-aut-name=IshiiAkira en-aut-sei=Ishii en-aut-mei=Akira kn-aut-name=石井明 kn-aut-sei=石井 kn-aut-mei=明 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部三朝分院内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第二内科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第二内科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第二内科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部寄生虫学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=ユスリカ kn-keyword=ユスリカ en-keyword=昆虫アレルギー kn-keyword=昆虫アレルギー en-keyword=交差反応性 kn-keyword=交差反応性 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue= article-no= start-page=45 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical problems of long-term steroid regimen for bronchial asthma, with reference to steroid-dependent cases kn-title=気管支喘息のステロイド療法における2,3の問題点について―ステロイド依存性喘息を中心に― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Adverse side effects of steroid therapy were investigated in 32 asthmatic patients. Thirty-two patients were classified into three groups according to steroid therapy for the past five years; group 1 has been treated with continuous steroid therapy, group 2 with occasional steroid therapy and group 3 without steroid therapy. The results were as follows. 1. Group 1 showed a low level of serum cortisol at 8-9 a. m. The serum concentration of cortisol in patients with daily steroid regimen was lower as compared to that in patients with alternateday steroid therapy. 2. The daily profile of serum cortisol was low in the steroid dependent asthmatic patients, and little increase of serum cortisol level after the administration of prednisolone was shown in group 1. 3. Serum IgG and IgM levels were significantly low in steroid dependent asthmatic patients. 4. The level of serum potassium was low in group 1. en-copyright= kn-copyright= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=OkadaChiharu en-aut-sei=Okada en-aut-mei=Chiharu kn-aut-name=岡田千春 kn-aut-sei=岡田 kn-aut-mei=千春 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=5 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=6 ORCID= en-aut-name=GodaYoshinori en-aut-sei=Goda en-aut-mei=Yoshinori kn-aut-name=合田吉徳 kn-aut-sei=合田 kn-aut-mei=吉徳 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue= article-no= start-page=35 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical effects of swimming training in a hot spring pool on bronchial asthma kn-title=気管支喘息における温泉プールによる運動浴の臨床効果について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Five severe bronchial asthma patients with glucocorticoid therapy have had free swimming training in the hot spring pool at Misasa Medical Branch. The clinical effect of the swimming training was evaluated after 3 months' training. 1. A slight increase in pulse rate and blood pressure was observed immediately after 30 minutes, swimming, although no significant increase in the two parameters was shown 30 min. after the training. 2. No significant fall in ventilatory function tests such as % FVC, FEV(1.0)%, V(50) and V(25) was demonstrated following the swimming training in a hot spring pool. The results suggest that the free swimming training in a hot spring pool does not induce bronchoconstriction. 3. Clinical efficacy of the swimming training on bronchial asthma was evaluated according to a treatment score, an attack score and an asthmatic score. These scores were decreased during the swimming training. The results obtained in this study showed that free swimming training in a hot spring pool is one of the most suitable therapies for severe bronchial asthma patients. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=3 ORCID= en-aut-name=MurashimaMakoto en-aut-sei=Murashima en-aut-mei=Makoto kn-aut-name=村嶋誠 kn-aut-sei=村嶋 kn-aut-mei=誠 aut-affil-num=4 ORCID= en-aut-name=OkadaChiharu en-aut-sei=Okada en-aut-mei=Chiharu kn-aut-name=岡田千春 kn-aut-sei=岡田 kn-aut-mei=千春 aut-affil-num=5 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=6 ORCID= en-aut-name=KobashiHidetoshi en-aut-sei=Kobashi en-aut-mei=Hidetoshi kn-aut-name=小橋秀敏 kn-aut-sei=小橋 kn-aut-mei=秀敏 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue= article-no= start-page=29 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=好塩基球からのヒスタミン遊離に関する研究. 2. ハウスダスト抗原および抗ヒトIgEによるヒスタミン遊離 kn-title=Studies on the release of histamine from basophils 2. Histamine release induced by house dust extract and anti-IgE en-subtitle= kn-subtitle= en-abstract=好塩基球からのIgE-mediated histamine releaseの機序を,健康人(2名)および気管支喘息(4例)それぞれの代表例で比較検討した. 抗ヒトIgEの添加濃度別検討では,健康人および外因性喘息例いずれも有意のヒスタミン遊離の増加をしめしたが,Max. % histamine releaseをひきおこす抗ヒトIgEの濃度は比較的限られた範囲内にある傾向がみられた. 一方内因性喘息例では,いずれの抗ヒトIgE濃度でも有意のヒスタミン遊離はみられなかった. ハウスダスト抗原の添加濃度別検討では,ハウスダストが抗原である気管支喘息症例においてdose-dependentなヒスタミン遊離が観察されたが,使用された抗原濃度の範囲ではMax. % releaseをひきおこす至適濃度は明らかでなかった. kn-abstract=IgE-mediated release of histamine from whole blood was examined in two healthy and four asthmatic subjects by dose-dependent fashion. The significantly increased amount of histamine was released from basophils of both healthy and asthmatic subjects by a limited concentration of anti-IgE. Antigen (house dust) caused histamine release only from basophils of asthmatics who are sensitive to house dust. Basophils from one patients with asthma released no significant amount of histamine by anti-IgE. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=3 ORCID= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=御般政明 kn-aut-sei=御般 kn-aut-mei=政明 aut-affil-num=4 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=5 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=6 ORCID= en-aut-name=GodaYoshinori en-aut-sei=Goda en-aut-mei=Yoshinori kn-aut-name=合田吉徳 kn-aut-sei=合田 kn-aut-mei=吉徳 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第2内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第2内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第2内科 END start-ver=1.4 cd-journal=joma no-vol=53 cd-vols= no-issue= article-no= start-page=23 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=好塩基球からのヒスタミン遊離に関する研究. 1 自動分析装置による全血からのヒスタミン遊離の測定 kn-title=Studies on the release of histamine from basophils 1. Determination of histamine from whole blood by an automated fluorometric histamine analysis system en-subtitle= kn-subtitle= en-abstract=ヒスタミン自動分析装置により,健康人10名,気管支喘息23例の全血からのヒスタミン遊離を測定した. 抗ヒトIgEを添加した際のヒスタミン遊離は,健康人および外因性気管支喘息症例では有意の増加傾向を示したが,一方内因性喘息症例では遊離増加はほとんどみられなかった. ハウスダスト抗原添加では,ハウスダストが抗原である気管支喘息症例においてのみ全血からの有意のヒスタミン遊離の増加が観察された. 以上の結果より,ヒスタミン自動分析装置による全血からの遊離ヒスタミンの測定は,気管支喘息の病態解明の1手段として極めて有用であると考えられる. kn-abstract=Histamine released from whole blood was determined by an automated fiuorometric histamine analysis system. The increased release of histamine from basophils by anti-IgE was observed in ten healthy subjects and 12 extrinsic asthma patients, while the release in 11 intrinsic asthma patients was significantly less as compared to that in healthy and extrinsic asthma subjects. House dust extract caused a significant increase in the histamine release from basophils of the extrinsic asthma patients who are sensitive to house dust. It was concluded from this study that histamine released from basophils could be easily determined by an automated analysis system and that the method is useful for the diagnosis and study of allergy. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=3 ORCID= en-aut-name=MifuneMasaaki en-aut-sei=Mifune en-aut-mei=Masaaki kn-aut-name=御般政明 kn-aut-sei=御般 kn-aut-mei=政明 aut-affil-num=4 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=5 ORCID= en-aut-name=OhtaniJun en-aut-sei=Ohtani en-aut-mei=Jun kn-aut-name=大谷純 kn-aut-sei=大谷 kn-aut-mei=純 aut-affil-num=6 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=7 ORCID= en-aut-name=GodaYoshinori en-aut-sei=Goda en-aut-mei=Yoshinori kn-aut-name=合田吉徳 kn-aut-sei=合田 kn-aut-mei=吉徳 aut-affil-num=8 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第2内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第2内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第2内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第2内科 END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=26 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19841101 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=利用者の要望 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学農学部 END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=13 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Monitoring of Environmental Ionizing Radiation and Radioisotopes in Okayama City and the Vicinty (I) kn-title=岡山市周辺の環境放射線ならびに放射能の調査・研究(I) en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= en-aut-name=OnoBun-ichiro en-aut-sei=Ono en-aut-mei=Bun-ichiro kn-aut-name=小野文一郎 kn-aut-sei=小野 kn-aut-mei=文一郎 aut-affil-num=2 ORCID= en-aut-name=KanayamaMunetoshi en-aut-sei=Kanayama en-aut-mei=Munetoshi kn-aut-name=鑛山宗利 kn-aut-sei=鑛山 kn-aut-mei=宗利 aut-affil-num=3 ORCID= en-aut-name=HachiyaKinji en-aut-sei=Hachiya en-aut-mei=Kinji kn-aut-name=蜂谷欽司 kn-aut-sei=蜂谷 kn-aut-mei=欽司 aut-affil-num=4 ORCID= en-aut-name=SatohKimiyuki en-aut-sei=Satoh en-aut-mei=Kimiyuki kn-aut-name=佐藤公行 kn-aut-sei=佐藤 kn-aut-mei=公行 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学農学部 affil-num=2 en-affil= kn-affil=岡山大学薬学部 affil-num=3 en-affil= kn-affil=岡山大学RI共同利用津島施設 affil-num=4 en-affil= kn-affil=岡山大学RI共同利用津島施設 affil-num=5 en-affil= kn-affil=岡山大学理学部 END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=3 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19941225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Monitoring of Environmental Ionizing Radiation and Radioisotopes in Okayama City and the Vicinty (II) - An estimation of the external radiation from the environmental radiation dose - kn-title=岡山市周辺の環境放射線ならびに放射能の調査・研究（II）―環境レベルの空間線量からの外部被曝に関する評価― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Monitoring of environmental ionizing radiation and radioisotopes in Okayama city and the vicinity was carried out from the point of view of the external radiation from the environmental radiation dose. Although the fluctuation of monthly detected radiation dose throughout the year was rather low at each observation point, the mean value of dose equivalent was varied between the place of observation. From the observation of the distribution of environmental radiation dose in Okayama city, it was assumed that its distribution was well corresponded with the distribution of igneous rocks. The concentrations of radioisotopes in various kinds of rocks corrected in Okayama city and its vicinity were determined. It became apparent that high concentrations of radioisotopes, such as (134)Cs, (40)K, (226)Ra and (228)Th, were detected in igneous rocks, such as granite, gabbro and rhyolitic tuff, although the contents in sedimentary rocks, such as pelite, schist, psammite and limestone, were rather low. This result was in good agreement with that of the distribution of radiation dose in Okayama city. en-copyright= kn-copyright= en-aut-name=MioMitsunobu en-aut-sei=Mio en-aut-mei=Mitsunobu kn-aut-name=見尾光庸 kn-aut-sei=見尾 kn-aut-mei=光庸 aut-affil-num=1 ORCID= en-aut-name=KanayamaMunetoshi en-aut-sei=Kanayama en-aut-mei=Munetoshi kn-aut-name=鑛山宗利 kn-aut-sei=鑛山 kn-aut-mei=宗利 aut-affil-num=2 ORCID= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=3 ORCID= en-aut-name=OnoBun-ichiro en-aut-sei=Ono en-aut-mei=Bun-ichiro kn-aut-name=小野文一郎 kn-aut-sei=小野 kn-aut-mei=文一郎 aut-affil-num=4 ORCID= en-aut-name=HachiyaKinji en-aut-sei=Hachiya en-aut-mei=Kinji kn-aut-name=蜂谷欽司 kn-aut-sei=蜂谷 kn-aut-mei=欽司 aut-affil-num=5 ORCID= en-aut-name=SatohKimiyuki en-aut-sei=Satoh en-aut-mei=Kimiyuki kn-aut-name=佐藤公行 kn-aut-sei=佐藤 kn-aut-mei=公行 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学薬学部 affil-num=2 en-affil= kn-affil=岡山大学RI共同利用津島施設 affil-num=3 en-affil= kn-affil=岡山大学農学部 affil-num=4 en-affil= kn-affil=岡山大学薬学部 affil-num=5 en-affil= kn-affil=岡山大学RI共同利用津島施設 affil-num=6 en-affil= kn-affil=岡山大学理学部 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性重症難治性喘息に対する温泉療法の遠隔効果 kn-title=Distant effects of spa therapy on steroid-dependent intractable asthma en-subtitle= kn-subtitle= en-abstract=67例のステロイド依存性重症難治性喘息を対象に，温泉療法を行い，その即時的効果（1週間後）および遠隔効果（1年後），さらには，温泉療法後の継続療法の影響などについて検討を加えた。1．温泉療法1週間後の即時的効果は比較的高く，その有効率は，Ta．気管支攣縮型で61.5％，Tb．気管支攣縮＋過分泌型で82.7％，U．細気管支閉塞型で83.4％であった。2．温泉療法の遠隔効果では，その有効率は，Ta型で50.2％，Tb型で54.1％，U型で63.7％であった。3．温泉療法の遠隔効果は，その後の継続療法の有無によりかなり異なった結果であった。すなわち，継続療法を行った症例の有効率は，72.8〜91.7％と高く，一方，継続療法を行わなかった症例の有効率は，16.7〜40.0％の間にあった。これらの結果から，温泉療法の即時的効果を保つためには，その後の継続療法が極めて重要であることが示唆された。 kn-abstract=The immediate effects (IEs) and distant effects (DEs) of spa therapy were observed in 67 patients with steroid- dependent intractable asthma (SDIA). (1) The IEs of spa therapy evaluated one week after spa therapy were considerably high, and the efficacy rate was 61.5% in type Ta, 82.7% in type Tb, and 83.4% in type U asthmatics. (2) The DEs of spa therapy on SDIA were also observed. The efficacy rate was 50.2% in type Ta, 54.3% in type Tb and 63.7% in type U asthmatics. (3) The DEs　of spa therapy were different between cases with and without maintenance therapy (MT).　The efficacy rate of DEs was generally high (72.8〜91.7%) in cases with MT, and low (16.7〜40.0%) in cases without MT. These results show that MT is very important to keep the IEs of spa therapy high for a long time. en-copyright= kn-copyright= en-aut-name=TanazakiYoshiro en-aut-sei=Tanazaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院第二内科 en-keyword=lmmediate effects (即時的効果) kn-keyword=lmmediate effects (即時的効果) en-keyword=Distant effects (遠隔効果) kn-keyword=Distant effects (遠隔効果) en-keyword=Maintenance therapy (継続療法) kn-keyword=Maintenance therapy (継続療法) en-keyword=Spa therapy (温泉療法) kn-keyword=Spa therapy (温泉療法) en-keyword=Steroid-dependent intractable asthma (ステロイド依存性重症難治性喘息) kn-keyword=Steroid-dependent intractable asthma (ステロイド依存性重症難治性喘息) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=61 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on serum cortisol levels in patients with intractable asthma kn-title=重症難治性喘息における副腎皮質ホルモン投与の影響 en-subtitle= kn-subtitle= en-abstract=In order to investigate adverse effects of steroid therapy on adrenocortical function and immune function, serum cortisol levels, peripheral lymphocytes' counts and serum immuno-globulin levels were examined in 65 asthmatic patients. The asthmatic patients were classified into 3 groups according to steroid therapy for the past 3 years ; group T has been treated with continuous steroid therapy, group U with occasional steroid therapy and group V without steroid therapy. The results were as follows. 1. The mean of serum cortisol levels was lower significantly in group T as compared with that in group V, (groupT:4.0μg/d?, groupV:11.6μg/d?). 2. The average count of peripheral lymphocytes was more decreased in group T than in group V. The difference between the two groups was significantly, (group T:1659/mm(3), group V:2150/mm(3)). 3. The average levels of serum immunoglobinlins such as IgG, IgA and IgM was　 significantly lower in group T compared with that in group V, (group T :IgG 1062mg/d?, IgA 218mg/d?, IgM 148mg/d?, group V: IgG 1501mg/d?, IgA 279mg/de, IgM 227mg/d?). The results suggested that long-tetm steroid therapy remarkably suppressed adrenocortical function and immune function in patients with asthma. kn-abstract=重症難治性喘息におけるステロイド剤の副腎皮質機能，免疫能に及ぼす影響を調べるため，喘息患者65例を過去3年間のステロイド剤使用状況により，T群：依存性症例，U群：時に使用する症例，V群：非使用例の3群に分け，血清コルチゾール値，末梢血リンパ球数及び血清免疫グロブリンについて検討した。結果は，血清コルチゾール値：T群4.0μg／d?，V群11.6μg／d?，末梢血リンパ球数：T群1，659／mm（3）V群2，150／mm（3），I gG：T群1，062mg／d?，V群1．501mg／d?，IgA：T群218mg／d?，V群279mg／d?，IgM：T群148mg／d?，V群227mg／d?とT群はV群に比べ有意に低い平均値を示しステロイド剤の副腎皮質機能，免疫能への抑制作用が窺われた。また末梢血リンパ球数の減少は，高齢者のステロイド依存性例に顕著であった。 en-copyright= kn-copyright= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= en-aut-name=TadaSinya en-aut-sei=Tada en-aut-mei=Sinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=5 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=重症難治性喘息 (Intractable asthma) kn-keyword=重症難治性喘息 (Intractable asthma) en-keyword=血清コルチゾール (Serum cortisol) kn-keyword=血清コルチゾール (Serum cortisol) en-keyword=末梢血リンパ球 (Peripheral lymphocytes) kn-keyword=末梢血リンパ球 (Peripheral lymphocytes) en-keyword=血清免疫グロブリン (Serum immunoglobuiin) kn-keyword=血清免疫グロブリン (Serum immunoglobuiin) END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue= article-no= start-page=54 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on bronchial asthma induced by chironomid midges -comparison between positive and negative cases to house dust- kn-title=ユスリカ喘息に関する臨床的検討 ―HD陽性例および陰性例の比較検討― en-subtitle= kn-subtitle= en-abstract=In recent years it has been reported that chironomid migdes might be one of the causative allergens in bronchial asthma. In order to clarify the clinical characteristics of bronchial asthma induced by chironomid midges (Tokunagayusurika akamusi), 163 patients with bronchial asthma were studied. The subjects were divided into two groups ; cases with negative (0〜1 + ) and positive (2 + or more) RAST score to house dust. 1. Skin reaction to midges was positive in 54 cases (33.1%) out of 163 patients with bronchial asthma. Thirty-six cases (43.9%) out of 82 asthmatics with positive RAST score to house dust showed positive skin reaction to midges, but in 81 cases with negative RAST score, only 18 cases (22.2%) showed positive skin reaction. 2. Fourteen cases out of 85 asthmatics showed a significant amount of histamine release (more than 15%).　A significant amount of histamine release was observed in 12 cases (23.5%) out of 51 cases with positive RAST score, but in only two cases (5.9%) out of 24 cases with negative RAST score. 3. Specific IgE antibodies to CTT (Chiromonus thummi thummi) was positive in 12 cases (18.2%) out of 66 asthmatics. In 41 asthmatics with positive RAST score to house dust, 12 cases (29.3%) showed positive RAST score to CTT, though in 25 cases with negative RAST score to house dust no cases showed positive RAST score to CTT. In conclusion, cases with house dust allergy were more easily sensitized by chironomid migdes than those cases without house dust allergy. kn-abstract=近年ユスリカが気管支喘息の原因抗原となり得ることが報告されている。しかし，その臨床的特徴はいまだ明らかにされていない。このユスリカ抗原の特徴を検討する目的で，気管支喘息症例163例をHD（ハウスダスト）に感作されたRAST　score2＋以上の陽性例82例とscore1＋以下の陰性例81例とに分けて比較検討を行なった。その結果皮膚反応，ヒスタミン遊離，CTT抗原を用いた特異的IgE抗体いずれの検討においても，HDに感作された症例が，よりユスリカ抗原にも感作されやすいことが明らかになった。 en-copyright= kn-copyright= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=1 ORCID= en-aut-name=ArakiHiroyuki en-aut-sei=Araki en-aut-mei=Hiroyuki kn-aut-name=荒木洋行 kn-aut-sei=荒木 kn-aut-mei=洋行 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=3 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=4 ORCID= en-aut-name=TadaSinya en-aut-sei=Tada en-aut-mei=Sinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=5 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=6 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=7 ORCID= en-aut-name=MatsuokaHiroyuki en-aut-sei=Matsuoka en-aut-mei=Hiroyuki kn-aut-name=松岡裕之 kn-aut-sei=松岡 kn-aut-mei=裕之 aut-affil-num=8 ORCID= en-aut-name=IshiiAkira en-aut-sei=Ishii en-aut-mei=Akira kn-aut-name=石井明 kn-aut-sei=石井 kn-aut-mei=明 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学第二内科 affil-num=6 en-affil= kn-affil=岡山大学第二内科 affil-num=7 en-affil= kn-affil=岡山大学第二内科 affil-num=8 en-affil= kn-affil=岡山大学寄生虫学教室 affil-num=9 en-affil= kn-affil=岡山大学寄生虫学教室 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=ユスリカ (Chironomid midges) kn-keyword=ユスリカ (Chironomid midges) en-keyword=ヒスタミン遊離 (Histamine release) kn-keyword=ヒスタミン遊離 (Histamine release) en-keyword=ハウスダスト (House dust) kn-keyword=ハウスダスト (House dust) END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=5-6 article-no= start-page=477 end-page=492 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on membrane architecture of blood corpusclesPart U: Ultrastructural study of freeze-etched lymphocyte membranes kn-title=血液細胞膜構築の研究 第二編 Freeze-etching法によるリンパ球膜構築の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Depending on the surface immunoglobulin of the lymphocyte membrane, lymphocyte has been classified either as a surface immunoglobulin bearing cell (SIBC) or a non-SIBC. An ultrastructural approach of the freeze-etched lymphocyte membranes of normal subjects revealed the existence of micro-processes and small particles on its surface. The density of micro-processes on the lymphocyte membrane was distributed in the range from 0.3 to 6.8/μ(2), and its histogram showed two peaks at 0-1 and 3-4/μ(2). The lymphocytes of normal subjects, in whom SIBC was in 18 percent, were freeze-etched, and 28 percent of the lympbocytes showed higher density of micro-processes more than 3/μ(2). After the filtration of the lymphocytes through a tetron fiber column, the percentages of both SIBC and the lymphocytes showing the micro-processes more than 3/μ(2) were decreased simultaneously. In acute and chronic lymphocytic leukemias, the examination of lymphocyte subpopulations and the membrane architectures of the leukemic lymphocytes revealed the similar tendency of membrane property as observed in non-SIBC and SIBC of normal subjects. en-copyright= kn-copyright= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=5-6 article-no= start-page=459 end-page=476 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on membrane architecture of blood corpusclesPart T: Ultrastructural study of freeze-etched erythrocyte membranes kn-title=血液細胞膜構築の研究 第一編 Freeze-etching法による赤血球膜構築の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To study the biomembrane architecture, the ultrastructural observation of erythrocyte membranes was performed using the freeze-etching method. Freeze-etched erythrocyte membranes of normal subjects showed the smooth surface with small particles, which were measured 84±23 A in diameter, 3928±182/μ(2) in density in the internal surface (I.S.) and 147±30 A, 643±159/μ(2) in the external surface (E.S.). As the comparative study, the erythrocyte membrane of the patients with autoimmune hemolytic anemia (AIHA), systemic lupus erythematosus (SLE), dyserythroblastic anemia, paroxysmal nocturnal hemoglobinuria (PNH) and ovalocytosis were also examined with the freeze-etching method. The erythrocytes showing the functional or morphological abnormalities were proved to have a various type of abnormal architectures in the membranes. In AIHA and PNH, the improvement of anemia was observed after the administration of steroid hormon or vitamin E and was in the good correlation with the normalization of the erythrocyte membrane architecture. en-copyright= kn-copyright= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=94 cd-vols= no-issue=1-2 article-no= start-page=45 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case report of malaria in a foreign sailor in Japan kn-title=本邦に寄港中発症した外国人船員のマラリヤ en-subtitle= kn-subtitle= en-abstract= kn-abstract=A foreign soilor who had arrived by ship from Goa, India, was found to be infected with both Plasmodium falciparum and P. vivax. Although the P. vivax was a chloroquine-resistant type, Fansidal ? was effective and the patient recovered. As it was the season for proliferation of mosquitoes in Japan, the patient was isolated so as not to become a source of secondary infection. Knowing the place where a patient with high grade fever comes from is of great help in diagnosing malaria, which is seldom seen in Japan. en-copyright= kn-copyright= en-aut-name=KiraShohei en-aut-sei=Kira en-aut-mei=Shohei kn-aut-name=吉良尚平 kn-aut-sei=吉良 kn-aut-mei=尚平 aut-affil-num=1 ORCID= en-aut-name=IzumiTakehiro en-aut-sei=Izumi en-aut-mei=Takehiro kn-aut-name=泉武寛 kn-aut-sei=泉 kn-aut-mei=武寛 aut-affil-num=2 ORCID= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=緒方正名 kn-aut-sei=緒方 kn-aut-mei=正名 aut-affil-num=3 ORCID= en-aut-name=TonguYasumasa en-aut-sei=Tongu en-aut-mei=Yasumasa kn-aut-name=頓宮廉正 kn-aut-sei=頓宮 kn-aut-mei=廉正 aut-affil-num=4 ORCID= en-aut-name=AjiToshiki en-aut-sei=Aji en-aut-mei=Toshiki kn-aut-name=安治敏樹 kn-aut-sei=安治 kn-aut-mei=敏樹 aut-affil-num=5 ORCID= en-aut-name=InatomiSeiiti en-aut-sei=Inatomi en-aut-mei=Seiiti kn-aut-name=稲臣成一 kn-aut-sei=稲臣 kn-aut-mei=成一 aut-affil-num=6 ORCID= en-aut-name=TadaKeiichi en-aut-sei=Tada en-aut-mei=Keiichi kn-aut-name=多田恵一 kn-aut-sei=多田 kn-aut-mei=恵一 aut-affil-num=7 ORCID= en-aut-name=SuguriSetsuo en-aut-sei=Suguri en-aut-mei=Setsuo kn-aut-name=村主節雄 kn-aut-sei=村主 kn-aut-mei=節雄 aut-affil-num=8 ORCID= en-aut-name=IchikawaJunichi en-aut-sei=Ichikawa en-aut-mei=Junichi kn-aut-name=市川純一 kn-aut-sei=市川 kn-aut-mei=純一 aut-affil-num=9 ORCID= en-aut-name=MatsudaKiyoshi en-aut-sei=Matsuda en-aut-mei=Kiyoshi kn-aut-name=松田穆 kn-aut-sei=松田 kn-aut-mei=穆 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部寄生虫学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院集中治療部 affil-num=8 en-affil= kn-affil=香川医科大学病理学講座医動物 affil-num=9 en-affil= kn-affil=玉野市松田病院 affil-num=10 en-affil= kn-affil=玉野市松田病院 en-keyword=Malaria kn-keyword=Malaria en-keyword=Plasmodium vivax kn-keyword=Plasmodium vivax en-keyword=P. falciparum kn-keyword=P. falciparum en-keyword=Chloroquine-resistant kn-keyword=Chloroquine-resistant END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=11-12 article-no= start-page=1153 end-page=1158 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19831230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Correlation between cellular components and infiltrating cells in the lung tissue of asthmatics kn-title=気管支喘息におけるBALF中出現細胞と組織出現細胞との比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cell components in the peripheral lung area were examined in 24 asthmatic subjects by bronchoalveolar lavage (BAL) and transbronchoscopic lung biopsy (TBLB). In cases with increased percentage of lymphocytes in bronchoalveolar lavage fluid (BALF), the infiltration of eosinophils and mononuclear cells in the peripheral lung tissue was observed with a high frequency. The increased percentage of eosinophils in BALF correlated with the infiltration of eosinophils and neutrophils in the bronchiolo-alveolar region. A reverse correlation was observed between the macrophage count in the alveolar region and the percentage of eosinophils and lymphocytes in BALF. No significant correlation was present between the percentage of neutrophils in BALF and the infiltration of any type of cell in the lung tissue. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=2 ORCID= en-aut-name=KobashiHidetoshi en-aut-sei=Kobashi en-aut-mei=Hidetoshi kn-aut-name=小橋秀敏 kn-aut-sei=小橋 kn-aut-mei=秀敏 aut-affil-num=3 ORCID= en-aut-name=ShiodaYutaro en-aut-sei=Shioda en-aut-mei=Yutaro kn-aut-name=塩田雄太郎 kn-aut-sei=塩田 kn-aut-mei=雄太郎 aut-affil-num=4 ORCID= en-aut-name=MatsukaYoko en-aut-sei=Matsuka en-aut-mei=Yoko kn-aut-name=松香陽子 kn-aut-sei=松香 kn-aut-mei=陽子 aut-affil-num=5 ORCID= en-aut-name=TakeyamaHiroyasu en-aut-sei=Takeyama en-aut-mei=Hiroyasu kn-aut-name=竹山博泰 kn-aut-sei=竹山 kn-aut-mei=博泰 aut-affil-num=6 ORCID= en-aut-name=HaradaHiroshi en-aut-sei=Harada en-aut-mei=Hiroshi kn-aut-name=原田寛 kn-aut-sei=原田 kn-aut-mei=寛 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部第2内科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第2内科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第2内科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科学教室 en-keyword=BAL kn-keyword=BAL en-keyword=TBLB kn-keyword=TBLB en-keyword=リンパ球 kn-keyword=リンパ球 en-keyword=好酸球 kn-keyword=好酸球 END start-ver=1.4 cd-journal=joma no-vol=96 cd-vols= no-issue=3-4 article-no= start-page=405 end-page=410 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Two-year study of spa therapy for inpatients with bronchial asthma kn-title=気管支喘息に対する温泉療法の臨床効果 ―過去2年間の入院症例を対象に― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seventeen inpatients with bronchial asthma, including 15 steroid-dependent intractable asthmatics, received spa therapy (swimmimg tratning in a hot spring pool) for 3 months at Okayama University Medical School, Misasa Branch Hospital. Clinical effects of spa therapy on these patients were evaluated regarding patient age, age at onset of disease and each asthma type classified by clinical symptom. Spa therapy was markedly effective in 5 cases (29.4%), moderately so in 7 cases (41.2%) and slightly so in 4 cases (23.5%). Reduction of the corticosteroid dose was made possible in 12 patients (80%) out of the 15 steroid-dependent asthmatics. Spa therapy was more effective in patients over 41 years old and in patients whose age at onset was 21 years or over. Clinical symptoms were improved more in the asthmatic group with bronchiolar obstruction and with bronchospasm-hypersecretion than in cases showing only bronchospasm. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=2 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤真康 kn-aut-sei=周藤 kn-aut-mei=真康 aut-affil-num=3 ORCID= en-aut-name=NakagoJitsuo en-aut-sei=Nakago en-aut-mei=Jitsuo kn-aut-name=中郷実雄 kn-aut-sei=中郷 kn-aut-mei=実雄 aut-affil-num=4 ORCID= en-aut-name=MorinagaHiroshi en-aut-sei=Morinaga en-aut-mei=Hiroshi kn-aut-name=森永寛 kn-aut-sei=森永 kn-aut-mei=寛 aut-affil-num=5 ORCID= en-aut-name=OhtaniJun en-aut-sei=Ohtani en-aut-mei=Jun kn-aut-name=大谷純 kn-aut-sei=大谷 kn-aut-mei=純 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部第2内科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科学教室 en-keyword=温泉療法―水泳訓練― kn-keyword=温泉療法―水泳訓練― en-keyword=気管支喘息―副腎皮質ホルモン kn-keyword=気管支喘息―副腎皮質ホルモン END start-ver=1.4 cd-journal=joma no-vol=99 cd-vols= no-issue=7-8 article-no= start-page=891 end-page=901 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanism of the dissolution of enflurane and isoflurane into human, dog and bovine blood kn-title=揮発性吸入麻酔薬enflurane, isofluraneの血中溶解機序に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study was performed to elucidate the difference in the mechanism of the dissolution of enflurane and isoflurane into human, dog and bovine blood in terms of changes in the hematocrit using the highly accurate analytical method of direct gas chromatography. With enflurane, as the hematocrit increased, the blood-gas partition coefficient for human and bovine blood decreased linearly (P < 0.001), and that for dog blood increased linearly (P < 0.001). With isoflurane, as the hematocrit increased, the blood-gas partition coefficient for the blood of all three animals decreased linearly (P < 0.001). Enflurane has a stroger affinity for red cells than for plasma in dog blood, as indicated by positive linearlity, while the opposite is true in human and bovine blood, as indicated by negative linearlity. Isoflurane has a stronger affinity for plasma than for red cells as indicated by negative linearlity in human, dog and bovine blood. The characteristic value of the red cell/plasma partition coefficient was 2.92 for enflurane in dog blood, and 0.09 for isoflurane in human blood. en-copyright= kn-copyright= en-aut-name=TadaKeiichi en-aut-sei=Tada en-aut-mei=Keiichi kn-aut-name=多田恵一 kn-aut-sei=多田 kn-aut-mei=恵一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=血液/ガス分配係数 kn-keyword=血液/ガス分配係数 en-keyword=血球/血漿分配係数 kn-keyword=血球/血漿分配係数 en-keyword=enflurane kn-keyword=enflurane en-keyword=isoflurane kn-keyword=isoflurane END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=9 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=「岡大ライス」の候補品種の選定 en-subtitle= kn-subtitle= en-abstract= kn-abstract=現在，水田部門では毎年平均45〜50トン前後の米を収穫している。以前はその全量をJAに出荷していたが，平成16年からJAへの出荷を止めて，「岡大ライス」と称して生協食堂の米飯用と学内で販売を行ってきた。平成20年度の実績では生協に約37トン，宮下酒造（｢おお岡大｣用）に６トン，残り９トンを一般販売や学内販売している。現在，生協の食堂では‘ヒノヒカリ’と‘アケボノ’をブレンドして使用しているが，それよりも単一品種で安価で美味しい品種はないものかと探していた。九州沖縄農業研究センターで育成された‘あきまさり’(6))は，‘ヒノヒカリ’と同等の食味で収量性も約10％高いことが報告されている。また，‘にこまる’(5))は‘ヒノヒカリ’に比べ高温条件においても白未熟粒の発生が少なく(4))，収量性も優ることが報告されている。そこで，岡山大学フィールド科学センターの主力品種である‘ヒノヒカリ’，‘アケボノ’に‘あきまさり’，‘にこまる’を加えて，2005年と2006年に岡山農場の水田で試験栽培を行い，収量性および食味官能試験を行った。さらに，2007年に八浜農場で小面積の栽培を行い，センター職員および生協職員の協力を得て食味官能試験を行った結果について報告する。 en-copyright= kn-copyright= en-aut-name=SaitouKuniyuki en-aut-sei=Saitou en-aut-mei=Kuniyuki kn-aut-name=齊藤邦行 kn-aut-sei=齊藤 kn-aut-mei=邦行 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=沼野義和 kn-aut-sei=沼野 kn-aut-mei=義和 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小林恭子 kn-aut-sei=小林 kn-aut-mei=恭子 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=SenTrinh Thi kn-aut-sei=Sen kn-aut-mei=Trinh Thi aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=63 cd-vols= no-issue= article-no= start-page=58 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高齢者健常人および気管支喘息患者におけるカンジダ特異的IgGおよびIgG(4)抗体について kn-title=Difference in specific IgG and IgG(4) antibodies against Candida aibicans between healthy and asthmatic subjects in the elderly en-subtitle= kn-subtitle= en-abstract=高齢者(61才以上)の健常人48名および気管支喘息患者69例を対象に,カンジダ特異的IgGおよびIgG(4)抗体を測定し,その増加の機序について若干の検討を加えた｡なお,対照としては,30才以下の健常者および気管支喘息患者を選んだ。1.カンジダ特異的IgGおよびIgG(4)抗体価は,30才以下では,健常人に比べ気管支喘息症例で高い傾向が見られ,特異的IgG抗体では両者間に有意の差が見られた(p<0.05)。2.カンジダ特異的IgGおよびIgG(4)抗体は,健常人および気管支喘息症例いずれも加齢とともに増加する傾向が見られ,71才では,30才以下の症例に比べ有意に高い抗体価を示した｡3.61才以上の高齢者では,特異的IgG,IgG(4)抗体いずれにおいても,健常人と気管支喘息患者との間に有意の差は見られなかった。 kn-abstract=Specific IgG and IgG(4) antibodies against Canadida albicans were exmined in 48 healthy and 69 asthmatic subjects to analyze the mechanism causing an increased production of these immunoglobulins. 1. The level of C.albicans-specific IgG and IgG(4) antibodies was higher, not significantly in IgG(4), in asthmatics under 30 years of age, compared with healthy subjects of the same age group. 2. Specific IgG and IgG(4) antibody levels in both healthy and asthmatic subjects showed a tendency to increase with aging, and significant difference was present between cases under 30 years and cases over 70 years of age. 3. Any difference in the production of specific IgG and IgG(4) was not observed in elderly cases older than 60 years between healthy and asthmatic subjects. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=KotohNaoki en-aut-sei=Kotoh en-aut-mei=Naoki kn-aut-name=古藤直樹 kn-aut-sei=古藤 kn-aut-mei=直樹 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Candida albicans (カンジダ特異的IgG) kn-keyword=Candida albicans (カンジダ特異的IgG) en-keyword=Specific IgG kn-keyword=Specific IgG en-keyword=IgG(4) kn-keyword=IgG(4) en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) en-keyword=Aging (加齢) kn-keyword=Aging (加齢) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=52 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支肺胞洗浄液中に一過性の好中球増多をきたしたアトピー型喘息 kn-title=Transient bronchoalveolar neutrophilia in a patient with atopic asthma en-subtitle= kn-subtitle= en-abstract=経過中に気管支肺胞洗浄(BAL)液中に一過性の好中球増多が観察されたアトピー型喘息症例について,若干の臨床的観察を加えた｡症例は,64才の女性で,臨床症状,および血清IgE高値,ハウスダストに対するIgE抗体陽性などから,アトピー型喘息と診断された｡なお,経過観察し得た15ヵ月の間に2回の大発作が観察された｡1.第1回の大発作後,BAL液中好中球増多と換気機能の低下が観察された｡そして,このBAL液中好中球頻度は明らかな改善が見られた｡BAL液中の総細胞数および好中球の絶対数も徐々に減少傾向を示し,好中球頻度と同様,第2回目の大発作3ヵ月後には著明な減少が観察された｡同時にこの時期には,BAL液中リンパ球の増加も見られた｡しかし,BAL液中好酸球数は15ヵ月の経過観察中ほとんど変化は見られなかった｡ kn-abstract=Clinical course of one asthma patient (64 years old, female), who had an increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid, was observed in relation to the proportion of BAL cells and ventilatory function. The patient had large asthma attacks two times during her clinical course for 15 months observed. 1. An increased proportion of BAL neutrophils and suppression of ventilatory function were found after her first large asthma attacks. The increased proportion of BAL neutrophils continued for more than 5 months. A reduction in the proportion of BAL neutrophils was found 3 months after her second large asthma attack, accompanied by improvement of clinical symptoms and ventilatory function. The numbers of total cells and neutrophils in BAL fluid were also reduced. Transient increase in number of BAL lymphocytes was found 13 months after the first large attack when the number of BAL neutrophils was markedly decreased. The number of BAL eosinophils did not change during her clinical course. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=NakagiriYoshiyasu en-aut-sei=Nakagiri en-aut-mei=Yoshiyasu kn-aut-name=中桐善康 kn-aut-sei=中桐 kn-aut-mei=善康 aut-affil-num=10 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) en-keyword=transient BAL neutrophilia(一過性BAL液中好中球増多) kn-keyword=transient BAL neutrophilia(一過性BAL液中好中球増多) en-keyword=ventilatory function (換気機能) kn-keyword=ventilatory function (換気機能) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=36 end-page=42 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息の臨床分類とその細胞性および液性因子の特徴 kn-title=Characteristics of humoral and cellular factors participating in onset mechanism of asthma in　relation to clinical types classified by symptoms. en-subtitle= kn-subtitle= en-abstract=気管支喘息72例を対象に,その臨床病態の特徴を,気道炎症性の細胞および化学伝達物質の観察により検討した｡1.気道反応の特徴を換気機能の面から検討すると,II細気管支閉塞型において,MMF,V(50)やV(25)などの小ないし細気管支領域の換気障害を示すパラメーターの値は,Ia型,Ib型に比べ 有意の低下を示した｡2.気道細胞反応では,II型において,他の臨床病型に比べ,BAL液中好中球の出現頻度の有意の増加が観察された(Ia, p<0.001 ; Ib, p<0.01)｡好酸球の出現頻度は,Ib過分泌型において著しい増加傾向を示す症例が見られたが,その平均出現頻度には3病型間に有意の差は見られなかった｡3.好中球からのメジェー夕ー遊離では,ヒスタミン遊離は,Ia単純性気管支撃縮型において最も高い値が示されたが,推計学的には3病型間に有意の差は見られなかった｡ロイコトリエンC(4)では,Ia型においてII型に比べ有意に高い遊離が観察された(p<0.05)｡ロイコトリエンB(4)遊離には,3病型間に差は見られなかった｡ kn-abstract=Characteristics of each asthma type classified by clinical symptoms and　findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients with bronchiolar obstruction (type II) compared to the values of those with simple bronchoconstriction type (type Ia) and those with bronchoconstriction + hypersecretion (type Ib). 2. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was significantly higher in type II than in type Ia and type Ib. Several　patients with type Ib showed higher proportion of BAL eosinophils. 3. The release of LTC(4) from leucocytes was significantly lower in type II compared with type Ia and type Ib. There was no significant difference in the release of histamine and LTB(4) among the three asthma types. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=NakagiriYoshiyasu en-aut-sei=Nakagiri en-aut-mei=Yoshiyasu kn-aut-name=中桐善康 kn-aut-sei=中桐 kn-aut-mei=善康 aut-affil-num=10 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産婦人科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Asthma classification kn-keyword=Asthma classification en-keyword=BAL fluid kn-keyword=BAL fluid en-keyword=chemical mediators kn-keyword=chemical mediators END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=75 end-page=82 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=老年者気管支喘息における液性および細胞性免疫反応について kn-title=Humoral and cellular immune response in elderly patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息における液性および細胞性免疫反応について,老年者気管支喘息,老年者健常人,および若年者気管支喘息の間で比較検討を行った｡1.まず,液性免疫では,血清IgE値高値,ハウスダストやカンジダに対するIgE抗体陽性などのIgE系反応は,老年者気管支喘息においては明らかに観察されたが,老年者健常人では全く観察されなかった｡血清IgGおよびIgA値には3者間に有意の差は見られなかったが,血清IgMは,若年者喘息に比べ老年者喘息で有意に低い値を示した｡2.ハウスダストやカンジダに対するIgE抗体は老年者喘息において老年者健常人に比べより高い頻度で陽性であったが,一方,ハウスダストに対するIgG(4)抗体は3者聞に有意の差は見られなかった｡また,カンジダに対するIgG(4)抗体は,老年者喘息および健常人において,若年者喘息に比べ有意の高値を示した｡しかし,老年者の喘息と健常人との間には有意の差は見られなかった｡3.PPDによる遅延型皮膚反応は,若年者喘息に比べ老年者喘息において有意の減弱傾向を示した｡これらの結果は,老年者喘息はIgE系反応を有していること,そして,加齢による免疫反応の変化の影響を受けること,を示している｡ kn-abstract=Humoral and cellular immune responses in bronchial asthma were examined by comparing the results of older asthmatics (group OA) with those of older healthy subjects (group OH) and of younger asthmatics (group YA). In humoral immune response, IgE-mediated immune system expressed by elevated serum IgE levels and IgE antibodies for house dust mite (HDm) and/or Candida albicans was clearly found in older asthmatics, while there was no finding showing the presence of IgE-mediated immune response in older healthy subjects. There was no significant difference in levels of serum IgG and IgA among the three groups. However, the serum IgM level was significantly lower in older asthmatics than in younger asthmatics. IgE antibodies to HDm and/or Candida albicans were more frequently found in older asthmatics compared with older healthy subjects. In contrast, IgG(4) antibodies to HDm were not different among the three groups. IgG(4) antibodies to Candida albicans were significantly higher in both older groups than in younger group. However, there was no significant difference between asthmatic and healthy subjects in the elderly. Delayed skin reaction to PPD was significantly more decreased in older asthmatics. These results show that bronchial asthma in the elderly is characterized by the presence of IgE-mediated immune response and by the changes of immune response with aging. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=12 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=13 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=IgE kn-keyword=IgE en-keyword=IgG(4) kn-keyword=IgG(4) en-keyword=Immunoglobulings (免疫グロブリン) kn-keyword=Immunoglobulings (免疫グロブリン) en-keyword=PPD kn-keyword=PPD en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) en-keyword=加齢 kn-keyword=加齢 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=31 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息におけるハウスダストアレルギー. 血清IgE値とIgE抗体価と年齢との関連 kn-title=House dust mite allergy in patients with　bronchial asthma. Serum IgE levels and IgE antibody values in relation to patient age. en-subtitle= kn-subtitle= en-abstract=ハウスダストが原因抗原であるアトピー型気管支喘息50例を対象に,血清IgE値とIgE抗体価を年齢との関連のもとに検討した｡1.IgE抗体価は10-19才の年齢層の症例において最も高く,一方40才以上の症例では全般的に低い傾向が見られた｡2.10-19才の年齢層の症例では,IgE抗体価の高値と同時に血清IgE値も高い値を示したが,40才以上の症例では,IgE抗休価および血清IgE値いずれも10-19才の症例に比べ全般的に低い値を示した｡9才以下の症例では,IgE抗体価の高値にもかかわらず,血清IgE値は比較的低く,500IU/ml以下を示した症例が10例中5例に観察された｡これらの結果は,若年症例では,IgE抗体の産生亢進と総IgEの産生亢進が同時に見られること が多いが,9才以下ではIgE抗体産生亢進に総IgE産生亢進が必ずしもともなわない場合があることを示している｡また,40才以上の症例では,ハウスダストに対する過敏性は有しているものの,IgE抗体価および血清IgEは全般的に低い値を示す傾向が示唆された｡ kn-abstract=Serum IgE levels and IgE antibody values in relation to patient age were examined in 50 patients with house dust mite (HDm) sensitive asthma, 1. IgE antibody values to HDm were highest in patients between the ages of 10 and 19, and the　values generally low in those over the age of 40. 2. High IgE antibody values to HDm　were accompanied by high serum IgE levels in patients between 10 and 19. IgE antibody values and serum IgE levels were in general low in patients over age 40. In patient under　age 9, serum IgE levels were less than 500 IU/ml in 5 of the 10 subjects despite an increased value of IgE antibodies to HDm. These results suggest that an increased　production of IgE antibodies to HDm is usually accompanied by an increased production of total IgE in younger subjects. However, an increase in production of IgE antibodies is not always related to an increase in production of total IgE in patients under age 9. The results also show that production of IgE antibodies to HDm and total IgE is in general low in older patients despite the hyperreactivity to HDm. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=Serum IgE (血清IgE) kn-keyword=Serum IgE (血清IgE) en-keyword=IgE antibodies (IgE抗体) kn-keyword=IgE antibodies (IgE抗体) en-keyword=house dust mite (ダニ) kn-keyword=house dust mite (ダニ) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=24 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における気道炎症反応の臨床的意義｡慢性閉塞性細気管支炎との比較検討 kn-title=Clinical significance of airway inflammation in bronchcial asthma. Comparison with chronic obstructive bronchiolitis. en-subtitle= kn-subtitle= en-abstract=気管支喘息28例および慢性閉塞性細気管支炎9例を対象に,気道炎症反応の臨床的意義について検討を加えた｡1.気管支肺胞洗浄(BAL)液中の総細胞数は,慢性閉塞性細気管支炎において著明に増加しており(51.0×10(6)),気管支喘息(9.6×10(6))との間に有意の差が見られた｡2.BAL液中マクロファージの頻度は気管支喘息において,慢性閉塞性細気管支炎に比べ有意に高い値を示したが,絶対数での比較では両疾患群間に有意の差は見られなかった｡ 3.BAL液中リンパ球の頻度は,気管支喘息においてやや高い傾向が見られたが,絶対数の比較では慢性閉塞性細気管支炎において有意に高い値であった｡ 4.BAL液中の好中球は,その頻度および絶対数とも慢性閉塞性細気管支炎において著明に増加しており,これは気管支喘息と比べ有意に高い値であった｡ 5.BAL液中好酸球の頻度および絶対数は,気管支喘息においてやや高い値であったが,両疾患群間に有意の差は見られなかった｡以上の結果より,気管支喘息における気道炎症反応は,慢性閉塞性細気管支炎ほど高度ではない ことが明らかにされた。 kn-abstract=Clinical significanoce of airway inflammation was assessed in 28 patients with bronchial asthma, and the results were compared with those in 9 patients with chronic obstructive bronchiolitis (COB). 1. Total cell number in bronchoalveolar lavage(BAL) fluid was markedly increased in patients with COB (51.0×10(6)), which was significantly greater than that in those with bronchial asthma (9.6×10(6) ). 2. The proportion of BAL macrophages was significantly higher in patients with bronchial asthma than in those with COB. However, the, absolute number of BAL macrophages was not significantly different between them. 3. The proportion of BAL lymphocytes was higher in patients with bronchial asthma than in those with COB, but this difference was not signifcant. In contrast, the absolute number of BAL lymphocytes was significantly greater in patients with COB than in those with bronchial asthma. 4. The proportion and the number of BAL neutrophils were markedly increased in patients with COB compared to those with bronchial asthma. 5. The proportion and the number of BAL eosinophils were higher in patients with bronchial asthma than in those with COB, although these defferences were not significant. The results suggest that airway inflammation in bronchial asthma is not so intensive as that in COB. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=12 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=13 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=airway inflammation (気道炎症反応) kn-keyword=airway inflammation (気道炎症反応) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) kn-keyword=chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) en-keyword=lymphocytes (リンパ球) kn-keyword=lymphocytes (リンパ球) en-keyword=neutrophils (好中球) kn-keyword=neutrophils (好中球) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=11 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息におけるActivated Tリンパ球について,喘息発作との関連 kn-title=Activated blood T cells in patients with bronchial asthma. Relationship to asthmatic cycle. en-subtitle= kn-subtitle= en-abstract=気管支喘息14例を対象に,末梢血CD4(+)リンパ球の頻度,CD4／CD8比およびIL2R(+)Tリンパ球の頻度について,喘息発作との関連のもとに検討を加えた｡1.CD4(+)リンパ球の頻度は,非発作時の症例で最も高く,喘鳴のみの症例,発作の見られる症例へと順次低くなる傾向が見られたが,推計学的には有意の差は見られなかった｡CD4/CD8比も同様に,非発作時に最も高く,発作を有する症例では非発作時に比べ低い値を示したが,推計学的には有意の差は見られなかった｡2.IL2R(+)Tリンパ球(activated Tリンパ球)の頻度は,非発作時の症例で最も低く(3.5±1.1%),喘鳴のみをともなう症例(3.8±1.1%),発作の見られる症例(5.8±1.9%)へと順次高くなる傾向を示し,発作のある症例では,非発作および喘鳴のみの症例に比べ有意に高い値 を示した｡また,非発作時と発作のある時期にIL2R(+)Tリンパ球を観察し得た5症例では,非発作時2.9±0.8%,発作のある時期6.6±1.1%であり,発作のある時期に有意の高値を示した(p<0.001)。これらの結果は,発作のある時期にはactivated Tリンパ球の頻度が増加すること,そして,この増加はactivated Tリンパ球が喘息発作の病態と密接な関連を有していることを示唆するものと考えられた｡ kn-abstract=The number of CD4(+) T-Iymphocytes, CD4/CD8 ratio, and the number of IL2R(+) T-Iymphocytes (CD25) were examined in 14 patients with bronchial asthma, and the results were compared in three different asthma stages : symptom-free stage, wheeze stage, and attack stage. 1. The proportion of blood CD4(+) T-lymphocytes was more decreased in patients with asthma attacks than in those without symptoms. The CD4/CD8 ratio was also more　decreased in patients with attacks than in those without symptoms. However, these differences were not significant. 2. The proportion of blood activated T cells (IL2R(+) cells, CD25) was significantly increased in patients with attacks than in those without symptoms. The proportion of activated T cells in 5 asthma patients was 2.9±0.8% in　symptom-free stage and 6.6±1.1% in attack stage(p<0.001). These findings show that numbers of activated T-lymphocytes in peripheral blood were increased during asthma attacks, and this increase suggests the participation of　activated T cells in the pathogenesis of asthma. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=10 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=CD4(+) T cells (CD4(+)リンパ球) kn-keyword=CD4(+) T cells (CD4(+)リンパ球) en-keyword=CD4／CD8 ratio (CD4／CD8比) kn-keyword=CD4／CD8 ratio (CD4／CD8比) en-keyword=IL2R(+) T cells (IL2R(+)Tリンパ球) kn-keyword=IL2R(+) T cells (IL2R(+)Tリンパ球) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue= article-no= start-page=1 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性重症難治性喘息に対する温泉療法の重要性｡過去10年間の181例を対象に。 kn-title=Spa therapy is very important for the treatment of steroid-dependent intractable asthma (SDIA). Analysis of 181 patients with SDIA. en-subtitle= kn-subtitle= en-abstract=最近10年間に三朝分院へ入院し,温泉療法を受けたステロイド依存性重症難治性喘息181例を対象に,温泉療法の方法との関連のもとに,対象患者の背景について検討を加えた｡最近10年間に3種類の温泉療法が行われた｡温泉療法A(温泉プール水泳訓練)は初期(1982-1985),温泉療法B(水泳訓練+ヨードゾル吸入)は中期(1986-1989),また,温泉療法C(水泳訓練＋ヨードゾル吸入＋鉱泥湿布療法)は後期(1990-1991)に行われた｡1.当院へ入院し,温泉療法を受けたステロイド依存性重症難治性喘息(SDIA)患者の数は,1986年の2例から1991年の35例へと増加の傾向を示した｡2.SDIA患者のうち,60才以 上の症例および40才以降の発症症例の数は,1986年以降急激な増加傾向を示した｡3.鳥取県以外の他県(遠隔地)からの入院患者の頻度は,近年減少の傾向を示したが,その絶対数は増加の傾向であった｡4.血清IgE値はいずれの時期においても200IU/m?以下の症例が多い傾向が見られた｡5.臨床病型では,通常の喘息に比べIb型およびII型の頻度が高い傾向が見られた｡6.温泉療法の臨床効果は,温泉療法Aが行われた初期では70.0%,温泉療法Bの中期では74.7%,温泉療法Cの後期では89.7%であった。 kn-abstract=Characteristics of 181 patients with steroid-dependent intractable asthma (SDIA) who were admitted to our hospital and had spa therapy for last 10 years were examined in relation to the methods of spa therapy. For last 10 years, three kinds ofspa therapies were administered: spa therapy A (swimming training in a hot spring pool) in the first atage (1982-1985), spa therapy B (swimming training + inhalation of iodine salt solution) in the middle stage (1986 -1989), and spa therapy C (swimming training + inhalation of iodine salt solution + fango therapy) in the last stage (1990-1991) of this study. 1. The number of patients with SDIA who were admitted to our hospital and had spa therapy tended to increase from 2 in 1986 to 35 in 1991. 2. The number of SDIA patients over the age of 60 or over the age at onset of 40 tended to increase from the first stage to the last stage. 3. The proportion of patients from distant areas (prefectures other than Tottori) was decreasing for the last stage, although the number of these patients was increasing in recent years. 4. The proportions of patients divided by serum IgE levels and by clinical asthma types did not change for last 10 years. 5. The proportion of type Ib and type II asthma was considerably high in patients with SDIA for last 10 years. 6. Clinical effects of spa therapy were observed in 21 of the 30 (70.0%)patients with SDIA in the first stage (1982-1985) with spa therapy A, 68 of the 83 (74.7%) patients with SDIA in the middle stage (1986-1989) with spa therapy B, and 61 of the 68 (89.7%) patients with SDIA in the last stage (1990-1991) with spa therapy C. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=9 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=10 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=11 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=12 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=11 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=12 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=13 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=swimming training in a hot spring pool (温泉プール水泳訓練) kn-keyword=swimming training in a hot spring pool (温泉プール水泳訓練) en-keyword=inhalation of iodine salt solution (ヨードゾル吸入) kn-keyword=inhalation of iodine salt solution (ヨードゾル吸入) en-keyword=fango therapy (鉱泥湿布療法) kn-keyword=fango therapy (鉱泥湿布療法) en-keyword=SDIA kn-keyword=SDIA END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=2 article-no= start-page=129 end-page=134 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Differences in interpersonal values for three cohorts of new nursing students kn-title=看護学生における対人関係価値のコホートによる相違 en-subtitle= kn-subtitle= en-abstract=KG-SIV (Kikuchi-Gordon Survey of Interpersonal Values) was administered twice to three cohorts of new nursing students admitted to School of Health Sciences, Okayama University, respectively, in 1990, 1993, and 1996. For the first testing, they indicated the values that were important to them, while for the second they indicated those that were important to an ideal nurse they had in their mind. Analyses showed that perceived values of Support and Independence increased while those of Benevolence decreased with the admission years. They also showed a reduced level of aspiration for an ideal nurse, particularly in 1996. Findings were discussed as they were related with a socialization process that nursing students would undertake in prospective nurse training. kn-abstract=医療短大入学年(1990年,1993年,1996年)において異なるコホートをなす看護学生の対人関係価値を入学直後に自己像と理想のナース像についてKG-SIV(Kikuchi-Gordon Survey of Interpersonal Values)によって測定した｡その結果,自己像評定では入学年が進むにつれて｢支持｣や｢独立｣の価値を重視する傾向が増大するのに対し,｢博愛｣の価値は逆に重視されない傾向が見いだされた｡また,特に1996年では理想のナース像に対する要求水準が低くなることも明らかになった｡この結果を看護学生の社会化過程と関連づけて考察した｡ en-copyright= kn-copyright= en-aut-name=KatoKumiko en-aut-sei=Kato en-aut-mei=Kumiko kn-aut-name=加藤久美子 kn-aut-sei=加藤 kn-aut-mei=久美子 aut-affil-num=1 ORCID= en-aut-name=KondoMasuko en-aut-sei=Kondo en-aut-mei=Masuko kn-aut-name=近藤益子 kn-aut-sei=近藤 kn-aut-mei=益子 aut-affil-num=2 ORCID= en-aut-name=TadaMasako en-aut-sei=Tada en-aut-mei=Masako kn-aut-name=多田政子 kn-aut-sei=多田 kn-aut-mei=政子 aut-affil-num=3 ORCID= en-aut-name=NagataHiroshi en-aut-sei=Nagata en-aut-mei=Hiroshi kn-aut-name=永田博 kn-aut-sei=永田 kn-aut-mei=博 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部 affil-num=3 en-affil= kn-affil=香川県健康民生部 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部 en-keyword=対人関係価値 (interpersonal values) kn-keyword=対人関係価値 (interpersonal values) en-keyword=看護学生 (nursing students) kn-keyword=看護学生 (nursing students) en-keyword=コホート (cohorts) kn-keyword=コホート (cohorts) en-keyword=社会化 (socialization) kn-keyword=社会化 (socialization) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=87 end-page=95 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of salbutamol and disodium cromoglycate on Specific Airway Resistance (sRaw) and Specific Conductance (sGaw) in Bronchial asthma and Rheunmatoid arthritis. kn-title=気管支喘息および慢性関節リウマチにおける気道抵抗(sRaw)および気道コンダクタンス(sGaw)に対するサルブタモールまたはクロモリン吸入の影響 en-subtitle= kn-subtitle= en-abstract=We examined effects of salbutamol sulfate and disodium cromoglycate (cromolyn) on specific airway resistance (sRaw) and specific conductance (sGaw) in 6 patients with bronchial asthma (BA), 7 patients with rheumatoid arthritis (RA), and 5 subjects of controls, using a constant volume, whole body plethysmograph (Sensor Medics Corporation, Anaheim, California, U.S.A.). The results before and 30 minutes after inhalation of agents were compared to evaluate their effects on sRaw and sGaw. Before inhalation, the sGaw of BA was significantly lower than that of RA or controls, and there was no difference between that of RA and normal controls. The sGaw and sRaw in BA were significantly improved (P<0.01) after inhalation of salbutamol and those improvement after inhalation were significantly higher (P<0.01) in BA than those in RA or controls, however there was no difference between those of RA and controls. Although there was no sigificant change of sGaw and sRaw in all groups between before and after inhalation of cromolyn, the improvement of sRaw after inhalation was significantly higher in BA than in RA or controls (P<0.05), and that of sGaw was significantly higher in BA than in controls (P<0.05). kn-abstract=サルブタモールまたはdisodium cromoglycate(クロモリン)吸入液を,気管支喘息(以下BA)6例,慢性関節リウマチ(以下RA)7例,正常対照5例に吸入させ,吸入前および吸入後約30分に,気道抵抗(sRaw)と気道コンダクタンス(sGaw)を,定容積型体プレチスモグラフ(Sensor Medics Corporation, Anaheim, California, made in U.S.A.)を用いて測定した｡吸入前の値をsGawで比較すると,BAはRAや正常対照に比べ有意に閉塞の程度が強く,RAと正常対照の間では有意な差はなかった｡サルブタモール吸入の場合,BAでは吸入後にsRawおよびsGawの有意な改善(P<0.01)がみられ,それらの改善率(%)は,RAや正常対照と比べて有意に高く(P<0.01),RAと正常対照の間では改善率の有意な差は認めなかった｡クロモリン吸入の場合,いずれの群においても,sRawおよびsGawの吸入後の変化に有意差はみられなかったが,BAにおいて,sRawの改善率(%)はRAと正常対照に対して,またsGawの改善率(%)は正常対照に対して有意に高く(P<0.05),RAと正常対照の間では,sRaw,sGaw共に改善率(%)の明らかな差はみられなかった｡ en-copyright= kn-copyright= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=TakataItiro en-aut-sei=Takata en-aut-mei=Itiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=気道抵抗 (sRaw) kn-keyword=気道抵抗 (sRaw) en-keyword=気道コンダクタンス (sGaw) kn-keyword=気道コンダクタンス (sGaw) en-keyword=気管支喘息 (bronchial asthma) kn-keyword=気管支喘息 (bronchial asthma) en-keyword=慢性関節リウマチ (rheumatoid arthritis) kn-keyword=慢性関節リウマチ (rheumatoid arthritis) en-keyword=気管支拡張作用 (the effect of bronchodialation) kn-keyword=気管支拡張作用 (the effect of bronchodialation) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=55 end-page=61 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における血清免疫グロブリン値,末梢血リンパ球数と気管支肺胞洗浄液中の細胞成分との関連 kn-title=Serum immunoglobulin levels and peripheral lymphocyte count related to changes in cellular composition of bronchoalveolar lavage fluid in patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息26例(ステロイド依存性重症難治性喘息,SDIA 13例,非SDIA 13例)を対象に,血清免疫グロブリン,IgG,IgAおよびIgM値,および末梢血リンパ球数との関連のもとに,副腎皮質ホルモン長期投与による気道炎症細胞の出現頻度の変化について検討を加えた｡なお,年齢による影響を観察する目的で,SDIAおよび非SDIA各13例を,20-59才と60才以上の2群に分けて,それ ぞれのグループの特徴について検討した｡1.血清IgG,IgAおよびIgM値は,60才以上の症例において,いずれも非SDIA症例に比べ,SDIA症例で有意に低い値を示した｡一方,20-59才の症例群においては,IgG値のみSDIA症例で有意の低下傾向が見られた｡2.末梢血リンパ球数は,60才以上の症例では,SDIA症例で,非SDIA症例に比べ有意の低値を示したが,20-59才の症例では両群間に有意の差は見られなかった｡3.気管支肺胞洗浄(BAL)液中のリンパ球数 は,60才以上のSDIA症例で,非SDIA症例に比べ有意に少なく,また同時にこれらの症例ではBAL液中好中球が有意に多い傾向が観察された｡しかし,20-59才の症例群では,SDIAと非SDIAの間にいずれも有意の差は見られなかっ た｡これらの結果より,60才以上の症例では,20-59才の症例群に比べ,副腎皮質ホルモンの長期投与により,血清IgG,IgAおよびIgM値,末梢血リンパ球数の減少とともに,BAL液中のリンパ球減少,好中球増加をきたしやすいことが明らかにされた｡ kn-abstract=Changes in airway inflammation by glucocorticoids were examined in 26 patients with bronchial asthma, divided into two age groups ; 20-59 and 60+ years, in relation to serum immunoglobulin levels and peripheral lymphocyte count. 1. The levels of IgG, IgA and IgM were significantly lower in patients with steroid-dependent intractable asthma (SDIA) of age over 60 years than in those with non-SDIA of the same age group. In patients between the ages of 20 and 59, only serum IgG level was significantly lower in SDIA than in non-SDIA patients. 2. Peripheral lymphocyte count was significantly decreased in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. 3. Number of lymphocytes in bronchoalveolar lavage (BAL) fluid was significantly lower and number of BAL neutrophils was significantly higher in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. These results suggest that levels of IgG, IgA and IgM, and peripheral lymphocyte count were significantly suppressed in SDIA patients of age over 60, accompanied with decrease of BAL lymphocytes and increase of BAL neutrophils. en-copyright= kn-copyright= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=serum immunoglobulin levels (血清免疫グロブリン値) kn-keyword=serum immunoglobulin levels (血清免疫グロブリン値) en-keyword=lymphocytes (リンパ球) kn-keyword=lymphocytes (リンパ球) en-keyword=neutrophils (好中球) kn-keyword=neutrophils (好中球) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=glucocorticoids (副腎皮質ホルモン) kn-keyword=glucocorticoids (副腎皮質ホルモン) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=40 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ステロイド依存性重症難治性喘息における気道反応の特徴 kn-title=Characteristics of airway response in patients with steroid-dependent intractable asthma (SDIA) en-subtitle= kn-subtitle= en-abstract=年齢により3群(20-39才,40-59才,60才以上)に分類された気管支喘息86例(ステロイド依存性重症難治性喘息:SDIA;43例,非SDIA;43例)を対象に,気管支肺胞洗浄液(BALF)中の細胞成分および換気機能よりSDIAにおける気 道反応の特徴を検討した｡1.血清コーチゾ-ル値は,SDIA症例において, 非SDIA症例に比べいずれの年齢層においても有意の低値を示した｡2.BALF中リンパ球頻度は,40-59才および60才以上のSDIA症例において,同年齢の非SDIA症例に比べ有意の低値を示した｡一方,BALF中好中球頻度は,60才以上のSDIA症例で,同年齢層の非SDIA症例に比べ有意に高い値を示 した｡また,BALF中好酸球頻度は,いずれの年齢層においても,SDIAと非SDIA症例の間に有意の差は見られなかった｡3.換気機能では,% FVC, FEV1.0%,% MMF, % V(25)などの換気パラメーターは,60才以上の SDIA症例において,同年齢層の非SDIA症例に比べて有意の低値を示した｡ これらの結果は,40-59才あるいは60才以上のSDIA症例では,非SDIA症例に比べ,BALF中リンパ球頻度の低下,好中球頻度の増加,換気パラメーター値の低下などがより高度に見られることを示している｡ kn-abstract=Characteristics of airway response in steroid-dependent intractable asthma (SDIA) were examined in 86 asthma patients (43 with SDIA and 43 with non-SDIA) divided into three age groups: 20-39, 40-59 and 60+ years, by observing cellular composition of bronchoalveolar lavage (BAL) fluid and ventilatory function. 1. The level of serum cortisol was significantly lower in patients with SDIA than in those with non-SDIA in all age groups. 2. The proportion of lymphocytes in BAL fluid was significantly decreased in patients with SDIA compared to results in non-SDIA patients in the age between 40-59, and over 60+ years, While BAL neutrophils were significantly increased in SDIA patients compared to results in non-SDIA patients in the age group over 60 years. 3. Of ventilatory parameters, the values of % FVC, FEV(1.0%), % MMF and % V(25) were significantly lower in SDIA patients over the age of 60 compared with non-SDIA subjects of the same age group. These results show that in SDIA patients the proportion of BAL lymphocytes decreases and the proportion of BAL neutrophils increases with aging, and that ventilatory function in SDIA patients also decreases with aging compared to non-SDIA patients. en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御船尚志 kn-aut-sei=御船 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=6 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) en-keyword=bronchoalveolar cells (気管支肺胞洗浄液中の細胞) kn-keyword=bronchoalveolar cells (気管支肺胞洗浄液中の細胞) en-keyword=ventilatory function (換気機能) kn-keyword=ventilatory function (換気機能) en-keyword=glucocorticoids (グルココーチコイド) kn-keyword=glucocorticoids (グルココーチコイド) en-keyword=serum cortiosol levels (血清コーチゾール値) kn-keyword=serum cortiosol levels (血清コーチゾール値) END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=9 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における末梢血白血球および気管支肺胞洗浄液中の細胞からのヒスタミンおよびロイコトリエンC(4),B(4)遊離と気道過敏性 kn-title=Release of histamine and leukotrienes C(4) and B(4) from peripheral leucocytes and bronchoalveolar cells and bronchial hyperresponsiveness in patients with asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息を対象に,気管支肺胞洗浄(BAL)液中の細胞の出現頻度,末梢血白血球およびBAL細胞からのヒスタミン,ロイコトリエンC(4),B(4)遊離,気道過敏性などについて,患者年齢との関連のもとに検討を加えた｡1.BAL液中のリンパ球および好中球頻度は,60才以上の老齢症例で,20-49才の若青年症例に比べやや高い傾向が見られたが,推計学的には有意の差は見られなかった｡BAL液中の好酸球,好塩基細胞の頻度は,若青年症例で,老年症例に比べて高く,特に好塩基性細胞の頻度には両症例群間に有意の差が見られ(P<0.05)｡ 2.BAL細胞からのヒスタミン遊離は,若青年症例で,老年症例に比べ有意に多い傾向が見られた(P<0.001)｡一方,BAL細胞からのロイコトリエンC(4)遊離は,若青年症例に比べ,老年症例で多い傾向が見られたが,両症例群間に有意の差は見られなかった｡3.メサコリンに対する気道の反応性は,全般的に若青年症例で,老年症例に比べより強い傾向を示した｡そして,390μg/m?またはそれ以下の低濃度のメサコリンに反応を示す症例は,若青年症例では16例中12例(75.0%),老年症例では14例中5例(35.7%)であった｡以上の結果より,気道過敏性は,BAL細胞からの化学伝達物質遊離の変化やBAL細胞の頻度の変化とともに,加齢の影響を受けることが明らかとなった。 kn-abstract=The proportions of cells in bronchoalveolar lavage (BAL) fluid, the release of histamine, leukotrienes C(4) and B(4) from leucocytes and BAL cells, and bronchial reactivity to methacholine were examined in 40 patients with asthma in relation to patient age. 1. The proportions of lymphocytes and neutrophils in BAL fluid were higher in older patients over age 60 than in younger patients between 20 and 49. The proportions of eosinophils and basophilic cells in BAL fluid were higher in younger patients than in older patients, and the difference in the proportion of BAL basophilic cells was significant between the two groups (p<0.05). 2. The release of histamine from BAL cells was significantly higher in younger patients than in older patients (p<0.001). The release of LTC(4) from BAL cells was higher in older patients compared to younger patients. 3. Bronchial reactivity to methacholine was higher in younger patients than in older patients. The number of patients reactive to low concentration of methacholine (390μg/m? or less) was larger in younger patients (12/16 ; 75.0%) than in older patients (5/14 ; 35.7%). These results suggest that bronchial hyperresponsiveness changes with aging, accompanied by changes in the release of chemical mediators from BAL cells and in the proportion of BAL cells. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=BAL cells (BAL細胞) kn-keyword=BAL cells (BAL細胞) en-keyword=histamine (ヒスタミン) kn-keyword=histamine (ヒスタミン) en-keyword=leukotrienes (ロイコトリエン) kn-keyword=leukotrienes (ロイコトリエン) en-keyword=bronchial hyperresponsiveness (気道過敏性) kn-keyword=bronchial hyperresponsiveness (気道過敏性) en-keyword=asthma (気管支喘息） kn-keyword=asthma (気管支喘息） END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue= article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199409 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息における複合温泉療法と気道炎症反応 kn-title=Complex spa therapy and airway inflammation in bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息55例を対象に,複合温泉療法(温泉プール水泳訓練+ヨードゾル吸入+鉱泥湿布療法)を試み,その臨床効果と気道炎症反応との関連について,若干の検討を加えた｡1.複合温泉療法の臨床効果では,著効15例(27.3%),有効32例(58.2%),やや有効6例,無効2例であり,明らかに有効と判断された症 例は,55例中47例(85.5%)であった｡2.複合温泉療法は,気管支肺胞洗浄液(BALF)中の細胞成分(リンパ球,好中球,好酸球など)が多い症例,すなわち気道炎症反応がより強い症例により有効であった｡このことは,複合温泉療法が,単純性の(化学伝達物質による)気管支攣縮よりも,気道炎症反応をともなった病態により強く影響を及ぼすことを示している｡3.複合温泉療法による換気機能の改善(1秒量)は,BAL液中の好中球数が少ない症例においてより高度であった｡このことは,BAL液中に高度な好中球増多が見られる症例に対しては,より長期的な複合温泉療法が必要であることを示しているものと考えられた｡ kn-abstract=Efficacy of complex spa therapy was studied in 55 patients with bronchial asthma. Complex spa therapy was effective in 47 (85.5%) of the 55 patients with bronchial asthma : marked efficacy was observed in 15 (27.3%), moderate in 32 (58.2%), slight in 6 (10.9%) and no efficacy in 2 patients (3.6%). Improvement of clinical symptoms and findings by complex spa therapy was more clearly observed in patients with an increased proportion of BAL lymphocytes, neutrophils and eosinophils. These findings suggest that complex spa therapy more affects cell infiltration in the airways than bronchoconstriction induced by chemical mediators. Improvement of ventilatory function represented by FEV1.0% value was higher in patients with a low proportion of BAL neutrophils, suggesting that patients with increased number of BAL neutrophils require longer complex spa therapy than those without BAL neutrophilia. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=5 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=6 ORCID= en-aut-name=TakataIchiro en-aut-sei=Takata en-aut-mei=Ichiro kn-aut-name=高田一郎 kn-aut-sei=高田 kn-aut-mei=一郎 aut-affil-num=7 ORCID= en-aut-name=OchiKoji en-aut-sei=Ochi en-aut-mei=Koji kn-aut-name=越智浩二 kn-aut-sei=越智 kn-aut-mei=浩二 aut-affil-num=8 ORCID= en-aut-name=HaradaHideo en-aut-sei=Harada en-aut-mei=Hideo kn-aut-name=原田英雄 kn-aut-sei=原田 kn-aut-mei=英雄 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=8 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=9 en-affil= kn-affil=岡山大学医学部臨床検査医学 affil-num=10 en-affil= kn-affil=岡山大学医学部第2内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第2内科 en-keyword=complex spa therapy (複合温泉療法) kn-keyword=complex spa therapy (複合温泉療法) en-keyword=airway inflammation (気道炎症反応) kn-keyword=airway inflammation (気道炎症反応) en-keyword=bronchial asthma (気管支喘息) kn-keyword=bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=43 end-page=49 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=温泉療法による気管支喘息患者の心理的障害の改善 kn-title=Improvement of psychological disorders by spa therapy in patients with asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息に対する温泉療法(1-2ヶ月)による心理的障害の改善を評価するために,3種類の心理学的調査:CMI(Cornel Medical Index),SDS(Selfrationg Depression Scale),CAI(Comprehensive Asthma Inventory)を,気管支喘息患者37例を対象として,入院時と退院時に実施し比較した｡@CMIでは,身体的自覚症,呼吸器系症状およびCIJ症状が,温泉療法後に有意に改善した｡ASDS値が40以上の症例において,温泉療法後,平均値は45.7から37.5へ有意に減少した｡BCAIの種々の心理学的項目により評価した心理的障害は,温泉療法後に有意に改善した｡各心理項目の平均値であるCAIスコアは,治療後,37.1から27.8へ有意に低下した｡これらの結果から,気管支喘息患者に観察される心理的障害は,温泉療法により改善することが示唆された｡ kn-abstract=To evaluate improvement of mental disorders by spa therapy for 1-2 months, three kinds of psychological examinations, CMI (Cornel Medical Index), SDS (Selfrating Depression Scale) and CAI (Comprehensive Asthma Inventory) tests, were performed in 37 patients with asthma before and after spa therapy. 1. In CMI test, the scores of physical symptoms, respiratory symptoms, and CIJ symptoms significantly decreased after spa therapy. The score of psychical symptoms tended to decrease after the therapy, however, this was not significant. 2. The mean score of the subjects over 40 points in SDS test significantly decreased from 45.7 points before spa therapy to 37.5 after the therapy. 3. Mental disorders evaluated by various categories in CAI test were significantly improved after spa therapy. The average score in CAI test significantly decreased from 37.1 to 27.8 after the therapy. These results demonstrate that psychological disorders in patients with asthma are improved by spa therapy. en-copyright= kn-copyright= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=7 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) en-keyword=心理テスト（CMI, SDS, CAI) (CMI test, SDS test, CAI test) kn-keyword=心理テスト（CMI, SDS, CAI) (CMI test, SDS test, CAI test) END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue= article-no= start-page=14 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=199611 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=U型(細気管支閉塞)喘息と閉塞性細気管支炎における細気管支領域の炎症反応の差 kn-title=Difference in small airway inflammation between type U (bronchiolar obstruction) asthma and obstructive bronchiolitis en-subtitle= kn-subtitle= en-abstract=U型喘息と閉塞性細気管支炎の臨床的特徴について,換気機能および気道炎症反応を中心に検討を加えた｡1.年齢,および発症年齢とも閉塞性細気管支炎に比べU型喘息において高い傾向が見られた｡IgE系反応はU型喘息では観察されたが,閉塞性細気管支炎では見られなかった｡2.換気機能では,測定された全ての換気パラメーターにおいて,その値は閉塞性細気管支炎に比べU型喘息でより低い値を示し,FEV1.0%,% MMFおよび% V50では有意の差が見られた｡3.BAL液中好中球頻度は,U型喘息(55.7%),閉塞性細気管支炎(74.4%)いずれにおいても高い値を示したが,両者間に有意の差は見られなかった｡4.一方,BAL液中の絶対数では,U型喘息に比べ,閉塞性細気管支炎において,総細胞数,マクロファージおよび好中球数が有意の高値を示した｡5.また,lm?あたりの細胞数の比較でも,閉塞性細気管支炎で好中球数が著明な高値を示した｡これらの結果より,この2疾患では気道内好中球増多は同様に見られるものの,その気道炎症の程度は明らかに閉塞性細気管支炎でより高度であることが示された｡ kn-abstract=Ventilatory function and inflammatory cells in airways were compared between patients with type U (bronchiolar obstruction) asthma and those with obstructive bronchiolitis. 1. Age and age at onset were higher in patients with type U asthma than in those with obstructive bronchiolitis. IgE-mediated allergic reaction was observed in patients with type U asthma, but not in those with obstructive bronchiolitis. 2. In ventilatory function tests, all ventilatory parameters examined were lower in patients with type U asthma compared to those with obstructive bronchiolitis, and the differences were significant in FEV1.0% (p<0.001), % MMF (p<0.02), and V50 (p<0.01). 3. The proportion of BAL neutrophils was very high in type U asthma (55.7%) and obstructive bronchiolitis (74.4%), however, this was not significant. 4. Absolute numbers/BAL fluid of total cells, BAL macrophages and BAL neutrophils were significantly higher in patients with obstructive bronchiolitis than in those with type U asthma. 5. The results on absolute number/m? of BAL cells demonstrated that number of BAL neutrophils markedly larger in patients with obstructive bronchiolitis compared to those with type U asthma. These results show that high proportion of BAL neutrophils was observed in the two respiratory diseases, however, the degree of inflammation in airways was markedly greater in obstructive bronchiolitis. en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=2 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=3 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=4 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=TakeuchiKazuaki en-aut-sei=Takeuchi en-aut-mei=Kazuaki kn-aut-name=竹内一昭 kn-aut-sei=竹内 kn-aut-mei=一昭 aut-affil-num=7 ORCID= en-aut-name=NawaYuichiro en-aut-sei=Nawa en-aut-mei=Yuichiro kn-aut-name=名和由一郎 kn-aut-sei=名和 kn-aut-mei=由一郎 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=U型喘息 (Type Uasthma) kn-keyword=U型喘息 (Type Uasthma) en-keyword=閉塞性細気管支炎 (Obstructive bronchiolitis) kn-keyword=閉塞性細気管支炎 (Obstructive bronchiolitis) en-keyword=換気機能 (Ventilatory function) kn-keyword=換気機能 (Ventilatory function) en-keyword=BAL好中球 (BAL neutrophiIs) kn-keyword=BAL好中球 (BAL neutrophiIs) en-keyword=IgE系反応 (IgE-mediated allergy) kn-keyword=IgE系反応 (IgE-mediated allergy) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=51 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical effect of spa therapy on lumbargo kn-title=腰痛症に対する温泉療法の効果 en-subtitle= kn-subtitle= en-abstract=Clinical effect of spa therapy was evaluated in 12 patients with lumbargo by a scoring system based on the standard judgement of therapy for lumbargo by Japanese Society of Orthopedics. The score for each category of subjective symptoms, objective symptoms, daily life activity, and disorder of urinary bladder, and total score calculated from each score were compared before and after spa therapy. A significant improvement of subjective symptoms, daily life activity, and total score was observed after spa therapy. However objective symptom was not significantly improved. The effects of spa therapy was larger in patients under age of 65, and in those who had long-term spa therapy more than 80 days during their admission. The results suggest that spa therapy IS effective for patients with lumbargo. kn-abstract=腰痛症患者12例を対象に温泉療法の臨床効果について検討した｡臨床効果の判定は,日本整形外科学会の腰痛治療成績判定基準に基づき,自覚症状,他覚症状,及び日常生活動作などの項目を中心に,治療前後で比較検討した｡その結果,自覚症状,日常生活動作,総計では,治療前に比べ治療後に有意の改善がみられた｡また改善指数や改善率での検討でも温泉療法の有効性が示唆された｡年齢別(60才以上と60才未満),入院期間(80日以上と80日未満)別の 検討では,65才未満の症例,80日以上の入院の症例において,改善指数,改善率が,有意差はみられなかったもののより高い傾向がみられた｡ en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=1 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=2 ORCID= en-aut-name=YamamotoKazuhiko en-aut-sei=Yamamoto en-aut-mei=Kazuhiko kn-aut-name=山本和彦 kn-aut-sei=山本 kn-aut-mei=和彦 aut-affil-num=3 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=岩垣尚史 kn-aut-sei=岩垣 kn-aut-mei=尚史 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=6 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=腰痛症 (lumbargo) kn-keyword=腰痛症 (lumbargo) en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=腰痛治療判定基準 (scoring system based on the standard judgement of therapy for lumbargo) kn-keyword=腰痛治療判定基準 (scoring system based on the standard judgement of therapy for lumbargo) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=34 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息症例における臨床的特徴と鼻腔･副鼻腔のCT所見の関連について kn-title=Correlation between clinical features of asthma and computed tomographic findings of nose and maxillary sinus en-subtitle= kn-subtitle= en-abstract=気管支喘息26症例において喘息の臨床的特徴と,鼻腔･上顎洞のCT所見の関連について検討を加えた｡1.鼻腔粘膜肥厚はアトピー症例,非アトピー症例間で有意な差は認められなかった｡上顎洞における粘膜肥厚比率(1slice上の上顎洞面積に対し,上顎洞粘膜が占める割合)も,アトピー･非アトピーで差は認められなかった｡2.ステロイド依存群･非依存群においても,鼻腔粘膜肥厚･上顎洞粘膜肥厚に有意な差は認められなかった｡3.アスピリン喘息症例においては,非アスピリン喘息症例に比べ,上顎洞粘膜肥厚が顕著であっ たが有意ではなかった｡鼻腔粘膜肥厚は2群間で差は認められなかった｡4.発作時の一日喀痰量との関連では一日喀痰量が100m?以上の症例群では,喀痰量が50m?以下の群･50-100m?の群に比較して有意に上顎洞粘膜肥厚比率が高値を示した｡鼻腔粘膜比率に関しては3群間で有意な差を認めなかった｡以上の結果から,喀痰量の多い気管支喘息症例では,その病態に副鼻腔病変が影響を及ぼしている可能性が考えられ,副鼻腔病変に対する治療により,気管支喘息が改善する可能性が考えられた｡ kn-abstract=Extent of nasal and maxillary mucosa lesion was estimated in 26 asthmatics using computed tomographic scan in relation to clinical features of the disease. 1. No significant differences were present in nasal mucosal thickening between atopic and non-atopic subjects. No significant differences were also present in occupancy rate of mucosa in maxillary sinuses between the two asthma types. 2. Nasal mucosal thickening was not significant different between subjects with steroid-dependent intractable asthma (SDIA) and those without SDIA. Maxillary mucosal lesions were more extensive in subjects with SDIA than in those without SOIA. However, no significant differences were observed in occupancy rate between the two types. 3. No significant differences were observed in nasal mucosal thickenings between in subjects with and without aspirin-induced asthma (AlA). Although maxillary mucosa lesion in subjects with AlA was more extensive than that in those without AlA, the differences was not significant. 4. There was not any correlation between nasal mucosal thickening and amount of expectoration per day. However, significant differences were observed in maxillary sinus lesion between subjects with less amount (<50m?/day) and those with large amount of expectoration (100m?/day≦)(p<0.002), and between subjects with moderate amount (50-99m?/ day) and those with large amount of expectoration (p<0.002). The results might suggest that in asthmatics with large amount of expectoration, sinus diseases affect pathophysiology of asthma, and asthmatics with large amount of expectoration should have therapy for sinus disease to improve asthmatic status. en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=YamamotoKazuhiko en-aut-sei=Yamamoto en-aut-mei=Kazuhiko kn-aut-name=山本和彦 kn-aut-sei=山本 kn-aut-mei=和彦 aut-affil-num=2 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=岩垣尚史 kn-aut-sei=岩垣 kn-aut-mei=尚史 aut-affil-num=3 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=sinusitis kn-keyword=sinusitis en-keyword=nasal disease kn-keyword=nasal disease en-keyword=CT scan kn-keyword=CT scan en-keyword=expectoration kn-keyword=expectoration END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=28 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of spa therapy on peak expiratory flow in patients with bronchial asthma kn-title=ピークフローから見た気管支喘息に対する温泉療法の効果 en-subtitle= kn-subtitle= en-abstract=The aim of this study was to investigate effects of spa therapy on peak expiratory flow (PEF) in patients with bronchial asthma. Morning PEF metry was studied in fifty asthmatics who had spa therapy (swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy) for 5 - 9 weeks. Mean values of morning PEF at the initial stage, 5 and 9 weeks after spa therapy were assessed. In mild and moderate asthmatics, PEF significantly improved 5 weeks after spa therapy. In severe asthmatics, PEF showed significant increase 9 week. The number of subjects with PEF improvement more over 20%, compared with the intial value of PEF, were 50% at 5 weeks and 80% at 9 weeks after spa therapy in mild asthmatics. In moderate asthmatics, however, the number little changed between 5 (39.3%) and 9 weeks (38.9%) after the therapy. In severe asthmatics, 57.1% at 5 and 68.8% at 9 weeks. In asthmatics with the initial value of PEF<200L/m (low PEF group), the value showed significant increase 5 and 9 weeks after the therapy compared with the initial value. In asthmatics with the initial values of 200≦PEF<300 (middle PEF group) and　300≦PEF (high PEF group), the values showed no significant increase. The number of subjects with PEF improvement more than 20% showed a tendency to increase 9 weeks in low, middle and high PEF group, compared to the value after spa therapy (57.1% to 68.8%, 21.4% to 50% and 35.7% to 42.9%, respectively ). kn-abstract=気管支喘息に対する温泉療法の効果をピークフローメーターを用いて継時的(第1週,第5過,第9週)に検討した｡1.軽症･中等症では,第5週で有意にピークフロー (PEF)値は上昇した.重症気管支喘息例では第9週に有意な改善を認めた｡2.20%以上のPEF値の改善を認めた症例の割合は第5週では,軽症･中等症･重症群で40〜50%であったが,第9週では軽症群で80%,重症群で54.5%に増加していた｡中等症群では第5週と同等であった｡3.第1週のPEFが200(L/m)以下の症例では第5週,第9過とPEFの有意な改善を示したが,2001/2 myometrium), the accuracy was 85.0% by TV and 61.7% by TA (p<0.01). In regard to the minimum width of the intact myometrium and the thickness of the high echoic area measured by each method, significant differences were obserevd between the M2-group and the other two group by the two methods. These p-values in TV were more significant than those in TA. In evaluating the presence of cervical invasion, the accuray was 95.0% by TV, while 88.3% by TA. Thus TV was found to be more useful than TA in the evaluation of both myometrial invasion and cerical invasion. en-copyright= kn-copyright= en-aut-name=TomokuniHirotaka en-aut-sei=Tomokuni en-aut-mei=Hirotaka kn-aut-name=友國弘敬 kn-aut-sei=友國 kn-aut-mei=弘敬 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 en-keyword=子宮体癌 kn-keyword=子宮体癌 en-keyword=筋層浸潤 kn-keyword=筋層浸潤 en-keyword=頚部浸潤 kn-keyword=頚部浸潤 en-keyword=経腟走査 kn-keyword=経腟走査 en-keyword=超音波断層法 kn-keyword=超音波断層法 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=489 end-page=499 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The usefulness of transvaginal ultrasonography and MRI in endometrial carcinama : Evaluating myomertrial and cervical invasion kn-title=子宮体癌に対する経腟走査超音波断層法とMRIの有用性について―筋層浸潤と頚部浸潤の評価― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Between October, 1988 and March, 1991, twenty-mine patients with endometrial carcinoma bad both transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) performed following hysterectomy at the Departmetn of Gynecology and Obstetrics, Okayama University Medical School. The findings were compared with the pathological findings to determine the usefulness of each method. The sensitivity of dectecthing myometrial invasion was 100% by TVUS and 96% by MRI. The accuracy was 86% by each method. The depth of myometrial invasion was classified into 3 degrees [no myometrial invasion, superficial invasion (?1/2), deep invasion (>1/2)]. The correct diagnostic rate was 86% by TVUS and MRI. The minimum width and the minimum/maximum width ratio of the intact myometrium obtained by each method in the pathological deep invasion group were significantly lower than those obtained in the other two groups (p<0.01). The sensitivity, the accuracy and the specificity of detecting cervical invasion were 89%, 93% and 95% by both methods. There was no difference between TVUS and MRI for diagnosing myometrial and cerical invasion of endometrial carcinoma. en-copyright= kn-copyright= en-aut-name=YoshiharaEisuke en-aut-sei=Yoshihara en-aut-mei=Eisuke kn-aut-name=吉原英介 kn-aut-sei=吉原 kn-aut-mei=英介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科学教室 en-keyword=子宮体癌 kn-keyword=子宮体癌 en-keyword=経腟走査超音波断層法 kn-keyword=経腟走査超音波断層法 en-keyword=MRI kn-keyword=MRI en-keyword=筋層浸潤 kn-keyword=筋層浸潤 en-keyword=頚部浸潤 kn-keyword=頚部浸潤 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=1-2 article-no= start-page=41 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental studies on the effects of plasma protein and nitrous oxide on sevoflurane minimum alveolar concentration (MAC) in dogs kn-title=セボフルレン麻酔の Minimum Alveolar Concentration (MAC) に及ぼす血漿蛋白と笑気の影響に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of plasma protein concentration (TP) on sevoflurane plasma protein/gas partition coefficient and of hematocrit values (Ht) on sevoflurane red cell/gas partition coefficient were examined in dogs. Furthermore, the effects of TP and inhalated nitrous oxide on sevoflurane MAC and sevoflurane concentration in blood at 1 MAC were studied in dogs during sevoflurane anesthesia. Snginificantly posotive correlations were noted in vitro between TP and plasma/gas partition coefficient, and between Ht and red cell/gas partition coefficient. However, the change in blood/gas partition coefficient appeared to be affected by TP. Sevoflurane MAC and seveflurane concentration in blood at 1 MAC rose in positive correlation with the rise of TP with or without nitrous oxide in combination, but there was no correlation with Ht. This seemed to be related to the predominancy of sevoflurane to dissolve into the plasma. The sevoflurane MAC and sevoflurane concentration in blood were significantly lower in the 33% nitrous oxide combined group than those in the oxygen alone group, but there was no significant difference between the 66% nitrous oxide combined group and the 33% nitrous oxide combined group. Furthermore, TP affected the sevoflurane MAC but not the nitrous oxide MAC. en-copyright= kn-copyright= en-aut-name=MaetaMasato en-aut-sei=Maeta en-aut-mei=Masato kn-aut-name=前田正人 kn-aut-sei=前田 kn-aut-mei=正人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=セボフルレン kn-keyword=セボフルレン en-keyword=血漿蛋白 kn-keyword=血漿蛋白 en-keyword=笑気 kn-keyword=笑気 en-keyword=MAC kn-keyword=MAC END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=445 end-page=455 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on pathogenesis of intractable asthma Part 2. Clinical features of late onset intractable asthma kn-title=難治性喘息の発症病態に関する研究　第2編　中高年発症型難治性喘息の臨床像について en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogenesis of late onset intractable asthma (LOIA), 102 asthmatics were classified into early (<40y.o.) and late onset asthma (>40y.o.), or intractable and non-in-tractable asthma. Clinical and allergic examinations were evaluated in each asthma group. Sixty nine percent of the late onset asthmatics had perennial type attacks. IgG-as well as IgE-mediated allergic reactions were suggested by the findings of immediate skin reaction, IgE RIST and RAST score to Candida allergen and reactivity of basophils to anti-immunoglobulin antisera in LOIA. Neutrophils in bronchoalveolar lavage fluid increased significantly in LOIA as compared with the early onset intractable asthma (EOIA) groups (p<0.05). In the pulmonary function test, a striking fall of % V25 was observed in both EOIA ans LOIA. The chest X-ray film frequently revealed microndular shadows in LOIA. Marked morphological changes in the transbronchial lung biopsied specimens were observed in the late onset asthmatics. These findings suggest that a non-IgE reaction, neutrophil infiltration in the local allergic site and histolpgical changes of lung tissue lead to LOIA. en-copyright= kn-copyright= en-aut-name=NakayamaKengo en-aut-sei=Nakayama en-aut-mei=Kengo kn-aut-name=中山堅吾 kn-aut-sei=中山 kn-aut-mei=堅吾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=late onset kn-keyword=late onset en-keyword=intractable asthma kn-keyword=intractable asthma en-keyword=IgG kn-keyword=IgG en-keyword=neutrophil kn-keyword=neutrophil en-keyword=transbronchoscopic lung biopsy kn-keyword=transbronchoscopic lung biopsy END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=433 end-page=443 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on pathogenesis of intractable asthma Part 1. Characteristices of clinical and immuno-pathological findings in intractable asthma kn-title=難治性喘息の発症病態に関する研究　第1編　難治性喘息の臨床的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogenesis of intractable asthma, clinical features, allergic examinations, pulmonary functions and histological finding were evaluated in 27 intractable asthmatics compared with 33 non-intractable asthmatics. Almost all of the intractable asthmatics had chronic and perennial asthma attacks and also had highly frequent episodes of respiratory infection. IgG-as well as IgE-mediated allergic reactions were proved by the findings of skin reaction, IgE RAST score, precipitating antibody and reactivity of basophils to anti-immunoglobulin antisera in the intractable asthmatics but not in the non-intactable asthmatics. Neutrophils of BALF and peripheral blood increased markedly in the intractable asthmatics as compared with the non-intractable asthmatics. The fall of % V(25) on flow volume curve in the intractable asthmatics, indicated small air way obstruction. Micronodular shadows on the chest X-ray film were frequently seen in the intractable asthmatics. Many histological findings were shown on lung specimens obtained by TBLB in the intrac-table asthmatics. These findings indicate that multiple factors of allergic reaction mediated by IgG, migrated neutrophils and organic changes of lung tissue lead to severe and intractable asthma attack. en-copyright= kn-copyright= en-aut-name=NakayamaKengo en-aut-sei=Nakayama en-aut-mei=Kengo kn-aut-name=中山堅吾 kn-aut-sei=中山 kn-aut-mei=堅吾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=intractable asthma kn-keyword=intractable asthma en-keyword=Candida kn-keyword=Candida en-keyword=IgG kn-keyword=IgG en-keyword=neutrophil kn-keyword=neutrophil en-keyword=transbronchoscopic lung biopsy kn-keyword=transbronchoscopic lung biopsy END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1117 end-page=1125 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the role of interferon gamma (IFN-γ) in the pathogenesis of bronchial asthma : Evaluation of IFN-γ production induced by Candida or mite antigen in comparison with other factors of lymphocytic function kn-title=気管支喘息における interferon-γ (IFN-γ) 産生能に関する研究 第2編 気管支喘息における IFN-γ 産生能と各種リンパ球機能との比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is known that IFN-γ, T-cell lymphokine, has potent effects on immunoglobulin synthesis, leukotrienes synthesis and delayed-type hypersensitivity. These factors are thought to be closely related to allergic reactions in bronchial asthma. Therefore, IFN-γ production from peripheral blood mononuclear cells induced by Candida or mite antigen was examined in asthmatics, and relations with other lymphocytic functions were studied to eluciate the role of IFN-γ. The results were as follows : (1) There was a significant correlation between IFN-γ production and Candida specific serum IgG1 antibody. (2) There was a significant correlation between IFN-γ production and lymphocyte blastgenesis induced by Candida antigen. (3) High levels of IFN-γ production were observed in asthmatics with positive late phase or delayed phase skin reaction to Candida antigen compared to asthmatics with negative late phase or delayed phase skin reaction. (4) Asthmatics with positive Candida or mite specific IgE radioallergosorbent test(RAST) showed a low level of IFN-γ production compared to asthmatics with negative IgE RAST. These results indicate that asthmatics with low IgE antibody and activated lymphocytes show high levels of IFN-γ production, and in these low IgE asthmatics, IFN-γ may play an important role in the allergic reactions of bronchial asthma. en-copyright= kn-copyright= en-aut-name=KimuraGoro en-aut-sei=Kimura en-aut-mei=Goro kn-aut-name=木村五郎 kn-aut-sei=木村 kn-aut-mei=五郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=delayed-type hypersensitivity kn-keyword=delayed-type hypersensitivity en-keyword=IFN-γ kn-keyword=IFN-γ en-keyword=IgE antibody kn-keyword=IgE antibody en-keyword=IgG1 antibody kn-keyword=IgG1 antibody END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=3-4 article-no= start-page=241 end-page=246 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of cyclosporin A on liver regeneration kn-title=肝再生に及ぼす Cyclosporin A の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=When lymphokine activiated killer cells (LAK cell) induced by IL-2 are infused into the same strain C(3)H mice following 70% partial hepatectomy, they display an action to suppress liver regeneration. Therefore, when Cyclosporin A (CsA) which inhibits IL-2 production was administerd to mice following partial hepatectomy, we studied as our indicator the labeling index of hepatic parenchyma cells using Brdu. Our findings showed that proliferation of live cells at 36 hours following partial hepatectomy was promoted by CsA, and the streongest promotion occuring at a dose of 5mg/kg. Before anf after hepatectomy when CsA was administered at 10mg/kg for 3 dadys, a further strong proliferation increasing effect was observed, and under these conditions at 48 and 60 hours after hepatectomy a significant increase in liver weight was observed. Give the above results, CsA it thought to have a promoting effect in liver regeneration following hepatectomy. en-copyright= kn-copyright= en-aut-name=YamamotoHiroshi en-aut-sei=Yamamoto en-aut-mei=Hiroshi kn-aut-name=山本浩史 kn-aut-sei=山本 kn-aut-mei=浩史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=Cyclosporin A kn-keyword=Cyclosporin A en-keyword=肝再生 kn-keyword=肝再生 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=11-12 article-no= start-page=1059 end-page=1068 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of myocardial damage and cardiac residual capacity by Tl-201 myocardial scintigraphy in valvular heart diseases kn-title=Tl-201心筋シンチグラフィーを用いた心臓弁膜症における心筋性状及び心予備能の評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study was performed to clarify whether the extent-score (Ex-Score) calculated by Tl-201 myocardial scintigraphy is a reliable indicator of the severity of myocardial damage and cardiac residual capacity in valvular heart diseases. The subjects consisted of 38 patients (10 with aortic regurgitation (AR), 4 with aortic stenosis (AS), 13 with mitral regurgitation (MR) and 11 with mitral stenosis (MS)). Ex-Score were significantly correlated with the severity of myocardial damage found in biopsied specimens obtained intraoperatively (correlation efficiency to Ex-Score with cell diameter in AR, % fibrosis in AR, cell diameter in AS, electron microscopic score in MR and % fibrosis in MS was 0.873, 0.734, 0.970, 0.913 and 0.659, respectively). Ex-Score were also correlated with cardiac residual capacity determined by radioisotope angiography (correlation efficiency to Ex-Score with % ejection fraction in AR, % end-systolic volume in MR, % end-diastolic volume in MS was -0.764, 0.790 and -0.763, respectively). These results suggest that the severity of myocardial damage and cardiac residual capacity can be estimated by Tl-201 myocardial scintigraphy (Ex-Score) in valvular heart diseases. en-copyright= kn-copyright= en-aut-name=IndoShunju en-aut-sei=Indo en-aut-mei=Shunju kn-aut-name=因藤春秋 kn-aut-sei=因藤 kn-aut-mei=春秋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=Tl-201心筋シンチグラフィー kn-keyword=Tl-201心筋シンチグラフィー en-keyword=Extent Score kn-keyword=Extent Score en-keyword=心筋間線維量 kn-keyword=心筋間線維量 en-keyword=心筋細胞横径 kn-keyword=心筋細胞横径 en-keyword=電顕スコア kn-keyword=電顕スコア END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=853 end-page=861 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism of initial attack in intractable asthma Part 1. The possible role of various respiratory viruses in bronchial asthma kn-title=難治性喘息の発症に関する研究 第1編 気管支喘息の発症における各種気道感染ウイルスの役割に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Allergen exposure leads to production of the specific IgE antibody and bronchospasm in atopic asthmatics. However, in adult cases with non-atopic asthma, the mechanism of asthma attack is still unknown. We observed that many adult asthmatics had fever and cold symptoms immediately before developing their first attack. Therefore, we measured the serum antibody titers against nine viruses (Influenza A and B, Adenovirus, RSV, Coxsackie B type 3, CMV, Parainfluenza type 1, 2, and 3), and analyzed their relationship with other clinical paremeters to elucidate the possible role of virus infection in inducing asthma attack. (1) No difference in antibody titers was observed between atopic and non-atopic asthmatics. (2) Steroid-dependent asthmatics had a higher antibody against CMV, and lower antibody against Coxsackie virus as compared with non-steroid dependent patients. (3) The anti-CMV antibody showed a significant correlation with the specific IgG antibody and lymphocyte blastogenesis to Candida antigen. (4) To examine the cross reactivity between Candida antigen and CMV, Candida antigen-specific-human monoclonal antibody was used but the result was negative. These findings suggest that the relationship between CMV and Candida is important in the pathogenesis of non-atopic adult asthmatics, although the mechanism is still unknown. en-copyright= kn-copyright= en-aut-name=TakataMinoru en-aut-sei=Takata en-aut-mei=Minoru kn-aut-name=高田穣 kn-aut-sei=高田 kn-aut-mei=穣 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=intractable asthma kn-keyword=intractable asthma en-keyword=viral infection kn-keyword=viral infection en-keyword=Candida antigen kn-keyword=Candida antigen END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=833 end-page=842 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the allergic features of severe bronchial asthma kn-title=気管支喘息の重症化要因に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The allergic responses to mite and Candida antigen were analyzed in atopic and non-atopic asthmatics to clarify the mechanisms of severe bronchial asthma. Skin responses and serum level of antigen specific IgE to mite antigen were lower in severe atopic asthmatics, especially in intractable atopic asthmatics. The serum level of antigen specific IgG1 and responses of peripheral blood lymphocytes to mite antigen showed no difference with severity in either type of asthma. Atopic severe asthmatics had higher serum levels of antigen specific IgE antibodies to Candida antigen and higher serum levels of antigen specific IgG1 antibodies to Candida antigen than atopic mild and moderate asthmatics. Non-atopic severe asthmatics had higher serum levels of antigen specific IgG1 antibodies to Candida antigen and higher responses of peripheral blood lymphocyte to Candida antigen than non-atopic mild and moderate asthmatics. In atopic and non-atopic severe asthmatics, bronchial provocation tests by Candida antigen showed higher positive responses than mild and moderate asthmatics. These findings suggest that a common mechanism makes asthma severe in atopic and non-atopic asthma and that Candida antigen plays an important role in both types of asthma. en-copyright= kn-copyright= en-aut-name=NambaYasuo en-aut-sei=Namba en-aut-mei=Yasuo kn-aut-name=難波康夫 kn-aut-sei=難波 kn-aut-mei=康夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=重症化 kn-keyword=重症化 en-keyword=病型 kn-keyword=病型 en-keyword=カンジダ kn-keyword=カンジダ END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=21 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Antitumor effect of interferon-α, γ and/or tumor necrosis factor-α against human colon cancer line (LoVo) transplanted into nude mice kn-title=ヌードマウス可移植性ヒト大腸癌細胞株 LoVoに対する interferon-α,-γ, tumor necrosis factor-α の抗腫瘍効果の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated the in vivo antitumor effect of recombinant human interferon-α,γ (IFN-α,γ) and/or recombinant human tumor necrosis factor-α (TNF-α) against human colon cancer cells (LoVo) transplanted into nude mice. LoVo cells were very sensitive to IFN-γ and slightly sensitive to IFN-α and resistant to TNF-α in vitro by dye uptake method. Intravenous administration of IFN-γ significantly inhibited tumor growth transplanted subcutaneously into nude mice, but IFN-α and/or TNF-α did not show any antitumor effect. Labeling index on stanining with bromodeoxyuridune and mitotic index of LoVo cells treated with IFN-α,γ or TNF-α differed slightly from those of the control group. We previously reported that the synergistic antitumor effects on the three cell lines could be examined by the combined use of IFN-α and TNF-α and the mechanism of the synergism was arrested in the S phase of cell cycle of target cells. However in the cese of LoVo cells, the combined use of IFN-α and TNF-α was not effective and did not arrest the cells in tha S phase of cell cycle. Therefore, arrest in the S phase was suspected to be responsible from the synergistic antitumor activity of IFN-α and TNF-α on the sensitive targets. en-copyright= kn-copyright= en-aut-name=KataokaKazuhiko en-aut-sei=Kataoka en-aut-mei=Kazuhiko kn-aut-name=片岡和彦 kn-aut-sei=片岡 kn-aut-mei=和彦 aut-affil-num=1 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=2 ORCID= en-aut-name=MuroMasahiko en-aut-sei=Muro en-aut-mei=Masahiko kn-aut-name=室雅彦 kn-aut-sei=室 kn-aut-mei=雅彦 aut-affil-num=3 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=4 ORCID= en-aut-name=HorikiSadayuki en-aut-sei=Horiki en-aut-mei=Sadayuki kn-aut-name=堀木貞幸 kn-aut-sei=堀木 kn-aut-mei=貞幸 aut-affil-num=5 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=6 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=7 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=nude mouse kn-keyword=nude mouse en-keyword=human colon cancer kn-keyword=human colon cancer en-keyword=interferon kn-keyword=interferon en-keyword=tumor necrosis factor kn-keyword=tumor necrosis factor en-keyword=cell cycle kn-keyword=cell cycle END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical significance of Creola body in the sputum of bronchial asthmatics kn-title=気管支喘息における喀痰中の Creola body に関する研究　第1編　気管支喘息患者喀痰中における Creola body の臨床的意義についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To examine the clinicopathology of agglomerated bronchial epithelial cells, i. e. Creola body (CrB), in the sputum, the incidence of CrB stained by Papanicoloaou's method was evaluated in 46 bronchial asthmatics and 10 patients with obstructive pulmonary diseases, and then was compared with the pathogenetic factors of bronchial asthma. CrB was observed specifically in the sputum of bronchial asthmatics. CrB-positive cases had asthma attacks for more than 4 days and a high incidence of eosinophils in the sputum, but not CrB-negative cases. The presence of CrB in the sputum tended to be high in non-atopic asthmatics with a low serum IgE level, but had no significant correlation with either the incidence of neutrophils in the sputum, the present age of patients, the severity of the disease or bronchial hyperresponsiveness to acetylcholine. These findines suggest that the involvement of histolesional factors such as persistent bronchial contraction and release of major basic protein from eosinophils in the airway may lead to the formation of CrB. Also the appearance of CrB may be a useful index for pre-serious stage of asthma. en-copyright= kn-copyright= en-aut-name=IsoshimaKoji en-aut-sei=Isoshima en-aut-mei=Koji kn-aut-name=磯嶋浩二 kn-aut-sei=磯嶋 kn-aut-mei=浩二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=sputum kn-keyword=sputum en-keyword=Creola body kn-keyword=Creola body en-keyword=eosinophil kn-keyword=eosinophil en-keyword=neutrophil kn-keyword=neutrophil END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=809 end-page=820 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on IgG subclass antibodies in asthmatics with late asthmatic responses Part 2. Antigen-specific IgG subclass antibodies in the BALF of asthmatics with late asthmatic responses kn-title=遅発型気道反応におけるIgG サブクラス抗体に関する研究　第2編　気管支肺胞洗浄液中抗原特異的 IgG サブクラス抗体と遅発型気道反応の関連について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Immunoglobulin classes which induce a non-immediate asthmatic response (non-IAR) in the case of low level of IgE antibody are still unknown, although IAR is mediated by IgE. To elucidate the relationship between antibodies and late asthmatic responses (LAR), antigen-specific IgG subclass antibodies in the serum and bronchoalveolar lavage fluid (BALF) of asthmatics were measured by avidin-biotin ELISA before provocation by antigen. The BALF levels of IgG and IgG1 antibodies to mite and Candida antigen in bronchial asthmatics were higher than those in healthy subjects (p<0.05). Followed by inhalation of house dust or Candida antigen, bronchial asthmatics were divided into group A (higher levels of BALF IgG1 antibody) and gourp B (lower levels of BALF IgG1 antibody). The percentages of LAR including DAR after inhalation of house dust antigen in group A were significantly higher than those in group B (p<0.05). The percentages of LAR including DAR after inhalation of Candida antigen in group A were significantly higher than those in group B (p<0.01). In asthmatics with LAR after inhalation of house dust antigen or Candida antigen, the BALF levels of antigen-specific IgG and IgG1 antibodies were significantly higher than those in asthmatics without LAR of healthy subjects (p<0.01). In asthmatics with LAR after inhalation of house dust antigen or Candida antigen, the BALF levels of antigen-specific IgG and IgG1 antibodies were significantly higher than those in asthmatics without LAR of healthy subjects (p<0.01). In asthmatics with LAR, the relative (to albumin) of coefficients of excretion (RCE) in the BALF of antigen-specific IgG and IgG1 antibodies were higher than those in asthmatics without LAR of healthy subjects. These findings suggest that local production of antigen-specific IgG and IgG1 antibodies incerases in asthmatics with LAR, and that these antibodies may induce LAR. en-copyright= kn-copyright= en-aut-name=OgurusuKazuro en-aut-sei=Ogurusu en-aut-mei=Kazuro kn-aut-name=小栗栖和郎 kn-aut-sei=小栗栖 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=遅発型気道反応 kn-keyword=遅発型気道反応 en-keyword=IgG サブクラス抗体 kn-keyword=IgG サブクラス抗体 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=抗原吸入誘発試験 kn-keyword=抗原吸入誘発試験 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=797 end-page=807 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on IgG subclass antibodies in asthmatics with late asthmatic responses Part 1. Serum antigen-specific IgG subclass antibodies in asthmatics with late asthmatic response kn-title=遅発型気道反応におけるIgG サブクラス抗体に関する研究　第1編　血清中抗原特異的 IgG サブクラス抗体と遅発型気道反応の関連について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The immediate asthmatic response is mainly induced by IgE-dependent mechanisms. However, the late asthmatic response (LAR) is induced by inhalation of antigens without the participation of antigen-specific IgE antibodies in some asthmatics, especially in intractable asthma induced by Candida antigen. To elucidate the relationship between antibodies and those bronchial responses, the antigen-specific IgG subclass antibodies in sera from asthmatics were measureed and compared with IgE antibody. The avidin-biotin ELISA (enzyme-linked immunosorbent assay) method was established for the measurement of specific IgG and IgG subclass antibodies to mite or Candida antigen. Serum levels of IgG and IgG1 antibodies to mite and Candida antigen in bronchial asthmatics were significantly higher than those in healthy subjects (p<0.01). Bronchial asthmatics who were tested with inhalation of house dust or Candida antigen were divided into group A (higher levels of serum IgG1 antibody) and group B (lower levels of serum IgG1 antibody). The percentage of LAR including DAR after inhalation of house dust antigen in group A were significantly higher than those in group B (p<0.01). The percentages of LAR and LAR including DAR after inhalation of Candida antigen in group A were significantly higherSerum levels of house du than those in group B(p<0.01). Serum levels of antigen-specific IgG and IgG1 antibodies in asthmatics with LAR after inhalation of house dust or Candida antigen were significantly higher than those in asthmatics with IAR or non-responders (p<0.01). The serum level of specific IgE antibody to these antigens in asthmatics with LAR after inhalation of house dust or Candida antigen was slightly lower than that in the asthmatics without LAR, though the difference was not significant. These findings suggest that high serum levels of specific IgG and IgG1 antibodies to adequate antigens play a role in inducing an attack in asthmatics with LAR. en-copyright= kn-copyright= en-aut-name=OgurusuKazuro en-aut-sei=Ogurusu en-aut-mei=Kazuro kn-aut-name=小栗栖和郎 kn-aut-sei=小栗栖 kn-aut-mei=和郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=遅発型気道反応 kn-keyword=遅発型気道反応 en-keyword=IｇG サブクラス抗体 kn-keyword=IｇG サブクラス抗体 en-keyword=IgE 抗体 kn-keyword=IgE 抗体 en-keyword=抗原吸入誘発試験 kn-keyword=抗原吸入誘発試験 en-keyword=難治性喘息 kn-keyword=難治性喘息 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=791 end-page=801 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the regulation of eosinophils in bronchial asthma Part 2. Migratory responses of eosinophils from asthmatics kn-title=気管支喘息における好酸球動態の調節に関する研究　第2編　喘息患者末梢血好酸球の遊走能に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eosinophil infiltration in lung tissue is one of the characteristic features of bronchial asthma. Such cell infiltration seems to be induced by the eosinophil chemotactic factor (ECF). PAF and IL-5 are potent chemoattractants and activators for eosinophils. To evaluate the reactivity of eosinophils in asthmatics under various conditions, the migratory function of eosinophils to PAF and IL-5 was investigated by the modified Boyden chamber method. Eosinophils of asthmatics were highly purified using a flow cytometric method previously reported. The migratory response of the eosinophils of asthmatics was greater than that of healthy suljects. Eosinophils from atopic asthmatics showed a higher response to PAF than those from non-atopic asthmatics. Eosinophils in the attack stage showed a higher response than those in the non-attack stage. Hypodense eosinophils showed an increased migratory response. The migratory response was correlated to the serum concentration of ECP and blood eosinophil count. These findings suggest that the reactivity of eosinophils is heterogenous and relates to the degree of eosinophilia, and that IL-5 as well as PAF plays an important role in the pathogenesis of bronchial asthma. en-copyright= kn-copyright= en-aut-name=TakahashiHisaho en-aut-sei=Takahashi en-aut-mei=Hisaho kn-aut-name=高橋寿保 kn-aut-sei=高橋 kn-aut-mei=寿保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Eosinophil migratory response kn-keyword=Eosinophil migratory response en-keyword=Platelet-activating factor kn-keyword=Platelet-activating factor en-keyword=Interleukin-5 kn-keyword=Interleukin-5 en-keyword=Eosinophil heterogeneity kn-keyword=Eosinophil heterogeneity END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=777 end-page=787 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the role of neutrophils in intractable asthma Part 2. Leukotriene production of neutrophils by immunological stimulation kn-title=難治性喘息における好中球の役割に関する研究　第2編　好中球からの免疫学的刺激による Leukotrienes 産生能に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Previously, I reported that more leukotrienes (LTs) and superoxides were produced from the neutrophil-rich fraction by non-immunological stimulation with CaI in intractable asthmatics than in non-intractable asthmatics. This suggested that neutrophils are involved in the pathogenesis of intractable asthma. To investigate the process of neutrophil activation in intractable asthma, the LTs production from neutrophils by immunological stimulation was measured by high performance liquid chromatography (HPLC). LTs were produced from neutrophils by stimulation of anti-IgG and zymosan activated serum (ZAS), but not anti-IgE. However, there was no significant difference with each disease severity of asthma. The production from neutrophils was also detected by Candida antigen stimulation. Moreover, the production of LTC4 from neutrophils by this stimulation was higher in intractable asthmatics than in non-intractable asthmatics. These findings suggested that neutrophils are produced LTs by immunological stimulation such as by Candida antigen based on the IgG mediated allergy reaction, and play an important role in the pathogenesis of intractable asthma. en-copyright= kn-copyright= en-aut-name=ShimizuIkki en-aut-sei=Shimizu en-aut-mei=Ikki kn-aut-name=清水一紀 kn-aut-sei=清水 kn-aut-mei=一紀 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=好中球 kn-keyword=好中球 en-keyword=好酸球 kn-keyword=好酸球 en-keyword=ロイコトリエン kn-keyword=ロイコトリエン END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=641 end-page=654 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The pathogenesis of interstitial pneumonia and the role of cytokines kn-title=間質性肺疾患の病態に関する研究―気管支肺胞洗浄液中サイトカインの検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various cytokines are known to participate in the pathogenesis of interstitial pneumonia follewed by lung fibrosis due to the proliferation of fibroblasts and production of collagen fibers. Patients with interstitial pneumonia including idiopathic interstitial pneumonia (IIP) and interstitial pneumonia with collagen vascular disease (IP with CVD) were examined by bronchoalveolar lavage (BAL). Cytokines such as IL-1α,　TGF-α, and TGF-β in BAL fluid were measured by enzyme linked immunosorbent assay (ELISA). The concentrations of TGF-α and TGF-β in BAL fluid of patients with IIP and IP with CVD were higher than those of normal control, while IL-1α, in BAL fluid was detected in few patoents. The level of TGF-β in BAL fluid was higher in patients with greater decreases in pulmonary function and overt fibrosis on chest X-ray film, although TGF-α was higher in patients with milder disorders. The concentrations of TGF-α and TGF-β showed positive correlation with soluble IL-2 receptor as well as procollagen type V in BAL fluid. These results indicated that cytokines regulationg lung fibrosis play important roles in the pathogenesis of interstitial pneumonia. en-copyright= kn-copyright= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=間質性肺疾患 kn-keyword=間質性肺疾患 en-keyword=気管支肺胞洗浄法 (broncho alveolar lavage : BAL) kn-keyword=気管支肺胞洗浄法 (broncho alveolar lavage : BAL) en-keyword=Interleukin 1 (IL-1) kn-keyword=Interleukin 1 (IL-1) en-keyword=transforming growth factor α kn-keyword=transforming growth factor α en-keyword=transforming growth factor β kn-keyword=transforming growth factor β END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=763 end-page=775 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the role of neutrophils in intractable asthma Part 1. Leukotriene and superoxide production of neutrophils kn-title=難治性喘息における好中球の役割に関する研究　第1編　好中球からの Leukotrienes 産生能及び superoxide 産生能に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The role of neutrophils migrated in the sputum and bronchoalveolar lavage fluid of intractable asthmatics is not difficult to understand. The production of leukotrienes (LTs) and superoxide stimulated by the calcium ionophores (CaI) from neutrophil-rich fraction of 29 intractable, 70 non-intractable asthmatics and 18 healthy subjects was examined by high performance liquid chromatography and a cytochrome C reduction method. Significantly larger amounts of LTC(4) and LTB(4) were produced by CaI in the neutrophil-rich fraction from asthematics, than in that from the healthy subjects (p<0.01). Moreover, a significantly larger amounts of LTC(4) was producted in the fraction obtained from the intractable asthmatics than in that from the non-intractable asthmatics (p<0.05). However, there was no significant difference in LTB(4) production between the two groups of asthmatics. The production of superoxide by concanavalin A was significantly increased in the neutrophil-rich fraction from prednisolone-within-10mg-dependent asthmatics than in those from prednisolone-over-10mg-dependent patients (p<0.01). There were correlations between the LTC(4) and LTB(4) production, and also between LTB(4) and superoxide production. LTs and superoxide released from inflammatory cells, especially neutrophils, may play an important role in the pathgenesis of intractable asthma. en-copyright= kn-copyright= en-aut-name=ShimizuIkki en-aut-sei=Shimizu en-aut-mei=Ikki kn-aut-name=清水一紀 kn-aut-sei=清水 kn-aut-mei=一紀 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=好中球 kn-keyword=好中球 en-keyword=ロイコトリエン kn-keyword=ロイコトリエン en-keyword=スーパーオキサイド kn-keyword=スーパーオキサイド END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=779 end-page=789 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the regulation of eosinophils in bronchial asthma Part 1. Characterization of eosinophil chemotactic factor (ECF) derived from peripheral blood mononuclear cells stimulated with Candida antigen kn-title=気管支喘息における好酸球動態の調節に関する研究　第1編　喘息患者末梢血単核球由来の好酸球遊走因子（ECF）の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eosinophilic infiltration in bronchial tissue is characteristic in the pathogenesis of bronchial asthma. The eosinophil chemotactic factor (ECF) derived from mononuclear cells has been reported to have some effect on the cell infiltration, and interleukin-5 (IL-5), a lymphokine derived from T lymphocytes, to be a factor related to growth, chemotaxis and activation for eosinophils. Lymphocytes accumulated in the bronchoalveolar lavage fluids of non-atopic and severe asthmatics have been shown to be highly responsive to Candida antigen, and high ECF production was observed in non-atopic and severe asthmatics by measurement of ECF activity in the supernatant of peripheral blood mononuclear cells cultured with Candida antigen. In this report, the molecular weight by gel filtration and inhibition test using anti-murine IL-5 antibody were studied to characterize the lymphocyte-derived ECF. Gel filtration analysis of the ECF indicated a molecular weight of 20,000 to 65,000 Da with a peak of activity around 40,000 to 50,000 Da. The ECF activity was reduced by incubation with anti-murine IL-5 antibody, which suggests that the supernatant contains IL-5. ECF from mononuclear cells, containing IL-5, may play an important role in the pathogenesis of eosinophil infiltration in non-atopic and severe asthmatics. en-copyright= kn-copyright= en-aut-name=TakahashiHisaho en-aut-sei=Takahashi en-aut-mei=Hisaho kn-aut-name=高橋寿保 kn-aut-sei=高橋 kn-aut-mei=寿保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Candida antigen Eosinophil chemotactic factor kn-keyword=Candida antigen Eosinophil chemotactic factor en-keyword=Interleukin-5 kn-keyword=Interleukin-5 END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=735 end-page=746 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism and treatment of intractable asthma Part 2. The mechanism of specific thromboxane A(2) synthetase inhibitor in cell-mediated allergy in intractable asthmatics kn-title=難治性喘息の病態と治療に関する研究　第2編　難治性喘息における細胞反応型アレルギーに対する選択的 Thromboxane A(2) 合成酵素阻害剤の抑制機序について en-subtitle= kn-subtitle= en-abstract= kn-abstract=The specific thromboxane A(2) (TXA(2)) synthetase inhibitor (OKY-046) seems to be a useful drug in the treatment of intractable asthmatics. In this study, to clarify the action mechanism of OKY-046 and the relationship between TXA(2) and prostaglandin E(2) (PGE(2)) in cell-mediated allergy, the effect of the TXA(2) receptor antagonist (AA-2414), TXA2 analogue (STA(2)) and PGE(2) for peripheral blood mononuclear cells in adult intractable asthmatics was studied. OKY-046 significantly suppressed TXB(2) production and increased PGE(2) production from the peripheral blood mononuclear cells stimulated by PHA and Candida antigen, but AA-2414 had no effect. AA-2414 suppressed lymphocyte blastgenesis, but did not suppress significantly interleukin-2 (IL-2) or neutrophil chemotactic factor (NCF) production. Furthermore, STA(2) increased lymphocyte blastgenesis stimulated by Candida antigen partially, but not dose-dependently. On the other hand, PGE(2) suppressed significantly lymphocyte blastgenesis and IL-2 and NCF production in a dose-dependent manner. These findings suggest that the action mechanism of OKY-046 is a suppressive effect of cell-mediated allergy, and that TXA(2) and PGE(2) play an important role in the mechanism of intractable asthma. en-copyright= kn-copyright= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Intractable asthma kn-keyword=Intractable asthma en-keyword=thromboxane A(2) kn-keyword=thromboxane A(2) en-keyword=prostaglandin E(2) kn-keyword=prostaglandin E(2) en-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) kn-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) en-keyword=thromboxane A(2) receptor antagonist (AA-2414) kn-keyword=thromboxane A(2) receptor antagonist (AA-2414) END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=7-8 article-no= start-page=721 end-page=733 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=199208 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism and treatment of intractable asthma Part 1. Effects of a specific thromboxane A(2) synthetase inhibitor in lymphocyte and neutrophil functions in intractable asthmatics kn-title=難治性喘息の病態と治療に関する研究　第1編　難治性喘息患者のリンパ球および好中球機能に及ぼす選択的 Thromboxane A(2) 合成酵素阻害剤の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify whether thromboxane A(2) (TXA(2)) is involved in type III and IV allergy, so-called "cell-mediated allergy", the effects of a specific TXA(2) synthetase inhibitor, sodium ozagrel (OKY-046) on peripheral blood mononuclear cells and neutrophils in adult intractable asthmatics were studied. Lymphocyte blastogenesis and interleukin-2 (IL-2) production from peripheral blood mononuclear cells stimulated by PHA and Candida antigen in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. The neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor (ECF) from peripheral blood nomonuclear cells stimulated by Candida antigen in intractable asthmatics tended to be suppressed by OKY-046. Furthermore, leukotriene C(4) (LTC(4)) and superoxide (O(2)(-)) production from peripheral blood neutrophils in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. These findings suggest that TXA(2) plays an important role in the development of intractable asthma and OKY-046, which has a suppressive effect on type IV allergy caused by lymphocyte activation and on mediator release from neutrophils, might be a useful drug in the treatment of intractalbe asthmatics. en-copyright= kn-copyright= en-aut-name=KanehiroArihiko en-aut-sei=Kanehiro en-aut-mei=Arihiko kn-aut-name=金廣有彦 kn-aut-sei=金廣 kn-aut-mei=有彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Intractable asthma kn-keyword=Intractable asthma en-keyword=cell-mediated allergy kn-keyword=cell-mediated allergy en-keyword=thromboxane A(2) kn-keyword=thromboxane A(2) en-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) kn-keyword=thromboxane A(2) synthetase inhibitor (OKY-046) END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=1 article-no= start-page=7 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=200501 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Microscopic Surface Change of Polycrystalline Aluminum duringTensile Plastic Deformation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Roughening on free surface of polycrystalline metal during plastic deformation is closely related to the inhomogeneous deformation in the respective grain at the surface. Uniaxial tensile tests are carried out on annealed pure aluminum sheet specimens with various averaged grain sizes. The roughening is measured by a 3-dimensional stylus instrument to examine the roughness change in both sides of specimen surfaces at each strain. The irregularities on one side are reversed on the backside, when the averaged grain size is as large as the thickness of the specimen. Discussions are made on the relation between the surface shapes of both sides adopting the cross correlation factor. The strains of respective grains are also measured from the grain boundary shape before and after plastic deformation. There are some deviations in the strains of the grains and their standard deviation increases with the applied strain. en-copyright= kn-copyright= en-aut-name=WangXiaoqun en-aut-sei=Wang en-aut-mei=Xiaoqun kn-aut-name=王暁群 kn-aut-sei=王 kn-aut-mei=暁群 aut-affil-num=1 ORCID= en-aut-name=AbeTakeji en-aut-sei=Abe en-aut-mei=Takeji kn-aut-name=阿部武治 kn-aut-sei=阿部 kn-aut-mei=武治 aut-affil-num=2 ORCID= en-aut-name=TadaNaoya en-aut-sei=Tada en-aut-mei=Naoya kn-aut-name=多田直哉 kn-aut-sei=多田 kn-aut-mei=直哉 aut-affil-num=3 ORCID= en-aut-name=ShimizuIchiro en-aut-sei=Shimizu en-aut-mei=Ichiro kn-aut-name=清水一郎 kn-aut-sei=清水 kn-aut-mei=一郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Graduate School of Natural Science and Technology Okayama University affil-num=2 en-affil= kn-affil=Tsuyama College of Technology affil-num=3 en-affil= kn-affil=Dept. of Mechanical Engineering Okayama University affil-num=4 en-affil= kn-affil=Dept. of Mechanical Engineering Okayama University END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=619 end-page=628 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stusies on the pathogenesis in diffuse panbronchiolitis Part 2. Immune responses in diffuse panbronchiolitis kn-title=びまん性汎細気管支炎の病態に関する研究　第2編　びまん性汎細気管支炎患者の免疫能 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various immunological processes are suspected of having some relationship with the onset of diffuse panbronchiolitis (DPB). Therefore, the cellular and humoral immunity of patients with DPB were studied. Sera of patients with DPB showed a high frequency of positive RA factor and high titer of cold agglutinin. Delayed skin tests with phytohemagglutinin (PHA) and purified protein derivative (PPD) in patients with DPB revealed normal responses to PHA as nonspecific mitogen and suppressed responses to PPD as specific antigen, although lymphocyte blastogenesis in vitro showed suppressed responses to PHA. The proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid of DPB patients equaled that of normal controls. Furthermore, the CD4/CD8 ratio of T-cell subsets in BAL fluid of DPB patients were significantly lower than that of normal controls, although the CD4/CD8 ratio in peripheral blood of DPB were significantly higher than that in normal controls. The percentage of B-cells in the peripheral blood of DPB patients was hihger than that in normal controls. These data suggest that the activation of cellular and humoral immune mechanisms could play an important role in the pathogenesis of DPB. en-copyright= kn-copyright= en-aut-name=ShiraishiTakamasa en-aut-sei=Shiraishi en-aut-mei=Takamasa kn-aut-name=白石高昌 kn-aut-sei=白石 kn-aut-mei=高昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=びまん性汎細気管支炎 kn-keyword=びまん性汎細気管支炎 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=リンパ球サブセット kn-keyword=リンパ球サブセット en-keyword=皮内反応 kn-keyword=皮内反応 en-keyword=リンパ球幼若化反応 kn-keyword=リンパ球幼若化反応 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=611 end-page=618 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Stusies on the pathogenesis in diffuse panbronchiolitis Part 1. Cellular components in bronchoalveolar lavage fluid of diffuse panbronchiolitis kn-title=びまん性汎細気管支炎の病態に関する研究　第1編　びまん性汎細気管支炎患者の気道細胞反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Diffuse panbronchiolitis (DPB) is known as a chronic progressive inflammation of the peripheral airway followed by lethal respiratory failure. Bronchoalveolar lavage (BAL) was performed to clarify the pathogenesis of DPB compared to chronic bronchitis. The recovery rate of BAL fluid in DPB decreased, but total cell count increased enormously. Furthermore, increased proportions of neutrophils in BAL fluid from DPB patients was characteristic and included a relative decrease in alveolar macrophages. Patients with DPB were classified based on the presence or absence chronic airway infection with Pseudomonas aeruginosa. There was no significant difference in cellular components of BAL fluid among the patients with or without Pseudomonas infection. Patients with DPB showed both obstructive and restrictive ventilatory disturbances. There was no correlation between parameters of these respiratory functions and total cell counts or various cellular proportions in BAL fluid. Infiltrating cell density around bronchioles of patients with DBP was measured. Significantly higher cell density was shown in patinets with DPB compared to other disease controls. There were also significant negative correlations between cell density and respiratory parameters such as % vital capacity, % V50 and % V25. These results indicate that remarkable increase in neutrophils in BAL fluid and the marked cell infiltration around bronchioles in DPB patients could play a crucial role in the pathogenesis of DPB. en-copyright= kn-copyright= en-aut-name=ShiraishiTakamasa en-aut-sei=Shiraishi en-aut-mei=Takamasa kn-aut-name=白石高昌 kn-aut-sei=白石 kn-aut-mei=高昌 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=びまん性汎細気管支炎 kn-keyword=びまん性汎細気管支炎 en-keyword=慢性気管支炎 kn-keyword=慢性気管支炎 en-keyword=気管支肺胞洗浄 kn-keyword=気管支肺胞洗浄 en-keyword=緑膿菌 kn-keyword=緑膿菌 en-keyword=細気管支領域細胞密度 kn-keyword=細気管支領域細胞密度 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=569 end-page=574 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Characteristics of pathophysiology in adult patients with bronchial asthma, with reference to asthma classification kn-title=成人気管支喘息の臨床病態の特徴―臨床分類と関連して en-subtitle= kn-subtitle= en-abstract= kn-abstract=Two asthma calssification systems associated with the pathophysiology of the airways were evaluated in 30 adult patients with bronchial asthma. The systems were classification by clinical symptoms (clinical diagnosis) and classification by a score calculated from clinical findings and examinations (score diagnosis). Thirty subjects were classified into 15 patients with Ia. simple bronchoconstriction type, 6 with Ib. bronchoconstriction+hypersecretion type and 9 with II. bronchiolar obstruction type by clinical diagnosis. Fifteen subjects with type Ia comprised 10 patients with expectoration of 0-49 ml/day and 5 of 50-99 ml/day. The patients with expectoration of 50-99 ml/day were classified as type Ib by score diagnosis. The value of FEV1.0% was significantly lower in patients with type II than in those with type Ia. The value of % V25 was significantly lower in patients with type II asthma compared with type Ia and type Ib subjects. No significant difference was observed in the values of % FEV1.0% and % V25 between patients classified by clinical diagnosis and score diagnosis. The proportion of neutrophils in BAL fluid was significantly higher in patients with type II compared to those with types Ia ad Ib by both classification systems. The proportion of eosinophils in BAL fluid was significantly higher in types Ia-2 and Ib by clinical diagnosis and in type Ib by score diagnosis than those classified as type Ia-1 by both systems. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=7 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=8 ORCID= en-aut-name=SodaRyo en-aut-sei=Soda en-aut-mei=Ryo kn-aut-name=宗田良 kn-aut-sei=宗田 kn-aut-mei=良 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=11 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部第二内科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=成人喘息 kn-keyword=成人喘息 en-keyword=換気機能 kn-keyword=換気機能 en-keyword=気道炎症反応 kn-keyword=気道炎症反応 en-keyword=臨床病型 kn-keyword=臨床病型 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=563 end-page=568 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Release of leukotrienes (LTC4, D4, E4, B4) from bronchoalveolar cells of patients with bronchial asthma kn-title=気管支喘息患者における気道遊走細胞のロイコトリエン（LTC(4)，D(4)，E(4)，B(4)）産生能に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To evaluate the pathogenetic role of leukotrienes in bronchial asthma, the release of leukotrienes from bronchoalveolar lavage cells stimulated by calcium ionophore A23187 was measured by high performance liquid chromatography. The release of leukotrienes from bronchoalveolar lavage cells in asthmatics with simple bronchoconstriction did not increase compared to those with other types of asthma. The number of BAL eosinophils in asthmatics with bronchoconstriction and hypersecretion increased. The release of leukotriene C4 from BAL cells in asthmatics with type Ib (hypersecrection type) was higher than that in those with type Ia (bronchoconstriction type). The release of leukotriene B4 was also signicantly higher in asthmatics with type Ib than that in those with type II (bronchiolar obstruction type). The number of BAL neutrophils increased in asthmatics with bronchiolar obstruction. However, the release of LTB4 from BAL cells did not increase. In patients with diffuse panbronchiolitis, the number of BAL neutrophils increased and the release of LTB4 from BAL cells was significantly higher than that in asthmatics with bronchiolar obstruction. These results suggest that leukotrienes play a role in the pathogenesis of bronchial asthma with hypersecretion. en-copyright= kn-copyright= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=1 ORCID= en-aut-name=KawarayaMasashi en-aut-sei=Kawaraya en-aut-mei=Masashi kn-aut-name=瓦屋正志 kn-aut-sei=瓦屋 kn-aut-mei=正志 aut-affil-num=2 ORCID= en-aut-name=HiramatsuJunichi en-aut-sei=Hiramatsu en-aut-mei=Junichi kn-aut-name=平松順一 kn-aut-sei=平松 kn-aut-mei=順一 aut-affil-num=3 ORCID= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=4 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=5 ORCID= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=6 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=7 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=気管支肺胞洗浄法 kn-keyword=気管支肺胞洗浄法 en-keyword=ロイコトリエン kn-keyword=ロイコトリエン en-keyword=ケミカルメディエーター kn-keyword=ケミカルメディエーター END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=561 end-page=571 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on inhalation provocatopn test of Candida antigen in bronchial asthma kn-title=気管支喘息におけるカンジダ抗原吸入誘発試験の臨床的検討―遅延型気道反応を中心に― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various allergic mechanisma participate in the reversible bronchospasms of an asthma attack. Candida albicans was suspected as the causative antigen in late-onset and severe intractable asthma. In this study, inhalation provocation test was performed with Candida antigen to evaluate the asthmatic responses of asthmatic patients with positive skin reaction to Candida antigen. More than 20% decrease in park flow after antigen inhalation was considered an asthmatic response and such responses were classified as immediate (IAR), late (LAR) or delayed (DeAR) depending on the time course after antigen inhalation. Provocation tests induced asthmatic responses in 26(42.6%) patients and 11(42.3%) showed DeAR. Eight of the 11 patients with DeARs had late onst asthma and 7 patients had intractable asthma. Furthermore, patients with DeARs showed higher lymphocyte responses to Candida antigen than those with IAR or LAR. These date indicate that EeAR to Canidia antigen plays an important role in the pathogenesis of severe intractable asthma. en-copyright= kn-copyright= en-aut-name=InokiAtsuhiro en-aut-sei=Inoki en-aut-mei=Atsuhiro kn-aut-name=猪木篤弘 kn-aut-sei=猪木 kn-aut-mei=篤弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=カンジダ抗原 kn-keyword=カンジダ抗原 en-keyword=吸入誘発試験 kn-keyword=吸入誘発試験 en-keyword=遅延型気道反応 kn-keyword=遅延型気道反応 en-keyword=リンパ球幼若化反応 kn-keyword=リンパ球幼若化反応 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=539 end-page=547 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanism of immunotherapy related to the production of antigen specific IgG subclass antibodies and leukotrienes in bronchial asthmatics kn-title=気管支喘息患者における減感作療法に作用機序に関する研究―抗原特異的IgGサブクラス抗体とロイコトリエン産生能に及ぼす影響について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism of immunotherapy in bronchial asthma, the level of mite specific IgG subclass asntibodies (total IgG, IgG(1), IgG(4)) and the production of leukotrienes (LTB(4), LTC(4)) released from leukocytes were examined. Eighteen mite-sensitive asthmatic patiens who received immunotherapy with house dust extract for 1 year were dividel into two groups, the responsive patients and non-responsive patients. Before treatment and 1 year after treatment, the levels of mite specific serum IgG subclass antibodies were measured by enzyme-linked immunosorbent assay (ELISA) and the levels of LTs were measured by high performance liquid chromatography (HPLC). In the responsive group, the level of mite specific serum IgG(4) antibody was significantly increased (p<0.05), and the level of mite specific serum total IgG and IgG(1) antibody was decreased. The release of LTB(4) and LTC(4) from leukocytes stimulated by mite antigen was significantly decreased (p<0.05,p<0.05). These results indicate that increases in the antigen specific IgG(4) and the inhibiton of chemical madiators play important roles in the mechanism of immunotherapy. en-copyright= kn-copyright= en-aut-name=KatagiSachie en-aut-sei=Katagi en-aut-mei=Sachie kn-aut-name=片木幸恵 kn-aut-sei=片木 kn-aut-mei=幸恵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=immunotherapy kn-keyword=immunotherapy en-keyword=IgG subclass antibodies kn-keyword=IgG subclass antibodies en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=527 end-page=537 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the cause of intractable asthma using animal model Part 2. Immunoglobulin G, chemical mediators and cell reactions in BALF and peripheral blood of chronic asthma model kn-title=慢性喘息モデルによる喘息の難治化要因に関する研究　第2編　肺局所や血液中における出現細胞及び液性反応に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism of intractable asthma, we examined the cellular content and chemical mediators in BALF and peripheral blood of a chronic asthma model which we had already established by inhalation of ascaris suum antigen. The serum levels of antigen specific IgG antibody on the eighth day were signicantly higher than those before inhalation. The serum levels of antigen specific IgG(1) antibody increased on the eighth day compared with levels before inhalation. The serum levels of antigen specific IgG(2) antibody as a blocking antibody increased and immediat asthmatic response (IAR) gradually improved until the fourth day. The number of eosinophils after eight days of inhalation was decrease in peripheral blood but was significantly increased in BAL and lung tissue. The serum levels of LTC(4) after eight days of inhalation decreased significanlty compared to those after one day of inhalation. LTB4 concentration in BAL after eight days of inhalation were significanlty lower than those after one day of inhalation. Histamine concentrations were increased in BAL in both the IAR and dual asthmatic response (DAR) animal model. These data suggest that intractable asthma was induced by many kinds of chemical mediators produced by inflammatory cells including eosinophils, mast cell-basophils, neutrophils and lymphocytes. en-copyright= kn-copyright= en-aut-name=SuganoHisashi en-aut-sei=Sugano en-aut-mei=Hisashi kn-aut-name=菅野尚 kn-aut-sei=菅野 kn-aut-mei=尚 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=chronic asthma kn-keyword=chronic asthma en-keyword=guinea pig kn-keyword=guinea pig en-keyword=IgG subclass antibodies kn-keyword=IgG subclass antibodies en-keyword=leukotrienes kn-keyword=leukotrienes en-keyword=histamine kn-keyword=histamine END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=517 end-page=525 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the cause of intractable asthma using animal model Part 1. Establishment of a chronic asthma model by repeated antigen inhalation kn-title=慢性喘息モデルによる喘息の難治化要因に関する研究　第1編　抗原の繰り返し吸入による慢性喘息モデルの作製 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the cause of intractable asthma, guinea pigs were actively sensitized by intraperitoneal injection of ascaris suum as an antigen. We repeated the inhalation of aerosolized ascaris antigen eight times in the animal models which consisted of a non-treated group, a metopirone-treated group and a steroid-treated group. We investigated the course of asthmatic response by evaluating the ratio of expirations to inspirations after the inhalation challenge. The frequency of late asthmatic response (LAR) was increased by repeated inhalation of the antigen. There was no significant differnce in the frequency between non-treated group and steroid-treated group, but the metopirone-treated group showed strong LAR compared with the other two groups. The intensity of LAR was gradually increased and that of immediate asthmatic response (LAR) was decreased in the metopirone-treated group. Finally, we established a chronic asthma model in which LAR was strong and the asthma attack was prolonged over twenty-four hours. These results suggest that the model will be useful in clarifying the causes of intractable asthma in humans. en-copyright= kn-copyright= en-aut-name=SuganoHisashi en-aut-sei=Sugano en-aut-mei=Hisashi kn-aut-name=菅野尚 kn-aut-sei=菅野 kn-aut-mei=尚 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=chronic asthma kn-keyword=chronic asthma en-keyword=animal model kn-keyword=animal model en-keyword=guinea pig kn-keyword=guinea pig en-keyword=re-inhalation kn-keyword=re-inhalation en-keyword=late asthmatic response kn-keyword=late asthmatic response END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=493 end-page=503 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on malignant lymphoma Part 1. Second malignant neoplasms in patients with malignant lymphoma after chemotherapy kn-title=悪性リンパ腫の病態と治療に関する研究　第1編　悪性リンパ腫化学療法後の2次癌発症についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The risk of a second malignancy was analyzed in 23 patients with Hodgkin's disease (HD) and 177 with non-Hodgkin's lymphoma (NHL) who were initially treated with combination chemotherapy between 1976 and 1990. Among these patients, 3 cases of gastric cancer, 2 cases of lung cancer, 2 cases of hepatoma, one case of colon cnacer, one case of cholangiocarcinoma and one case of acute myeloblastic leukemia were subsequently observed. Median age at diagnosis of lymphoma was 64 years in patients who developed subsequent malignancies but was 9 years higher than that for the entire lymphoma group. Median interval from srart of chemotherapy to the appearance of second malignancy was 43.9 years and ranged from 1.9 years to 8.8 years. The 7-year cumulative risk of second malignancy in HD and NHL were 7.7% and 11.7%, respectively. In Hodgkin's disease, the incidence of stomach and lung cancers was significantly greater than expected incidence calculated on the basis of age-adjusted person-years. In non-Hodgkin's lymphoma, the incidence was also greater than expected for all malignancies except stomach cancer. This indicater that the incidence of solid malignancy as well as leukemia is higher in lymphoma patients after chemotherapy than in the general population. en-copyright= kn-copyright= en-aut-name=TagawaShinya en-aut-sei=Tagawa en-aut-mei=Shinya kn-aut-name=田川真也 kn-aut-sei=田川 kn-aut-mei=真也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=malignant lymphoma kn-keyword=malignant lymphoma en-keyword=chemotherapy kn-keyword=chemotherapy en-keyword=second primary malignancy kn-keyword=second primary malignancy END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=11-12 article-no= start-page=1009 end-page=1017 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19931231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on chemotherapy for malignant lymphoma Part 1. Salvage chemotherapy for non-Hodgkin's lymphoma ; MEPP : Combination of mitoxantrone, etoposide, cisplatin and prednisolone kn-title=悪性リンパ腫の化学療法に関する研究　第1編　Mitoxantrone, Etoposide, Cisplatin, Prednisolone 併用療法(MEPP) による non-Hodgkin's lymphoma の salvage 治療の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Twenty six patients with non-Hodgkin's lymphoma (NHL), who failed to achieve complete remission or had relapsed after conventional chemotherapy (CHOP or CHOP-Bleo) were treated with a four-drug combination of mitoxantrone, etoposide, cisplatin and prednisolone (MEPP). Of 24 patients evaluated, five (21%) achieved complete remission and seven (29%) responded partially. The median duration of remission was 25 weeks, 38 weeks for complete responders (CRs), 24 weeks for partial responders (PRs). The median survival time after initiation of therapy was 93 weeks for CRs, 50 weeks for PRs and 25 weeks for non-responders (NRs). The difference in survival time between CRs and NRs was statistically significant. Myelosuppression was the major dose-limiting toxicity ; WBC nadir below 1,000/μl occurred in 66.2% of evaluable courses. Two patients with bone marrow involvement died of infection due to granulocytopenia. Renal toxicity of cisplatin was moderate and there was no cardiotoxicity of mitoxantrone detected. Despite severe myelotoxicity, these results indicate that MEPP regimen is useful as a salvage therapy for relapsed or refractory NHL. en-copyright= kn-copyright= en-aut-name=UenoKunio en-aut-sei=Ueno en-aut-mei=Kunio kn-aut-name=上野邦夫 kn-aut-sei=上野 kn-aut-mei=邦夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=非ホジキンリンパ腫 kn-keyword=非ホジキンリンパ腫 en-keyword=salvage 治療 kn-keyword=salvage 治療 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=5-6 article-no= start-page=455 end-page=464 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On localization of inhaled antigens in late asthmatic response in an animal model kn-title=遅発型気道反応の発現機序に関する基礎的研究―吸入抗原の局在について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the initiation of late asthmatic response (LAR), the localization and fate of inhaled antigens were studied using an animal model of LAR. Guinea pigs were sensitized by ascaris suum and aluminum gel. Radioiodinated ascaris suum and ovalbumin as control were subsequently injected into the trachea of the guinea pig to determine the radioactivity of bronchoalveolar lavege (BAL) cells and fluid (BALF) components before and after LAR. The localization of antigens was also examined by autoradiography of BAL cells and lung tissue sections. The radioactivity of radioiodinated ascaris in BAL cells and lung tissue increased during LAR with increases in macrophages and neutrophils, although in non-responding animals inhaled antigens gradualy disappeared from the airway. The radioactivity of radioiodinated ovalbumin gradually decreased regardless of LAR. Autoradiographic study showed that the inhaled antigens were located in the cytoplasm of alveolar macrophages in BALF and lung tissue. These data indicate that inhaled antigens may accumulate and migrate with numerous inflammatory cells such as macrophages and neutrophils in late phase bronchial response. en-copyright= kn-copyright= en-aut-name=TakedaKatsuyuki en-aut-sei=Takeda en-aut-mei=Katsuyuki kn-aut-name=武田勝行 kn-aut-sei=武田 kn-aut-mei=勝行 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=alveolar macrophage kn-keyword=alveolar macrophage en-keyword=guinea pig kn-keyword=guinea pig en-keyword=(125)I-ascaris kn-keyword=(125)I-ascaris en-keyword=late asthmatic response (LAR) kn-keyword=late asthmatic response (LAR) en-keyword=localization of inhaled antigen kn-keyword=localization of inhaled antigen END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=5-6 article-no= start-page=461 end-page=471 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=HTLV-T infection in patients with pneumoconiosis in regard to complications of malignancy kn-title=塵肺症におけるHTLV-T感染の検討―悪性腫瘍との関連を含めて― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The pathogenesis of pneumocniosis following exposure to inorganic dust remains obscure. HTLV-T, known as a cause of adult T cell leukemia, has been reported to participate in various interstitial lung diseases. So, HTLV-T infection in patients with pneumoconiosis was inves-tigated by detecting anti-HTLV-T antibodies by the indirect immunofluorescent methoh and the pX gene by polymerase chain reaction (PCR) and Southern blotting. Furthermore, various malignancies in pneumoconiosis were also analyzed in relation to HTLV-T infection. Three of 24 patients (12.5%) demonstrated anti-HTLV-T antibodies. Four of 5 patients includ-ing the 3 patients with antibodies demonstrated the pX gene. Various malignant diseases including myelodyspastic syndrome and lung cancer showed a higher incidence in patients with HTLV-T infection than in those without HTLV-T infection. These findings indicate that HTLV-T infection could play an important role in the path-ogenesis of pneumoconiosis and complications of malignancy. en-copyright= kn-copyright= en-aut-name=SasakiTakashi en-aut-sei=Sasaki en-aut-mei=Takashi kn-aut-name=佐々木高 kn-aut-sei=佐々木 kn-aut-mei=高 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=塵肺症 kn-keyword=塵肺症 en-keyword=HTLV-T (human T-lymphotropic virus type T) kn-keyword=HTLV-T (human T-lymphotropic virus type T) en-keyword=間接蛍光抗体法 kn-keyword=間接蛍光抗体法 en-keyword=免疫電顕法 kn-keyword=免疫電顕法 en-keyword=PCR (polymerase chain reaction method)　法 kn-keyword=PCR (polymerase chain reaction method)　法 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=415 end-page=428 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of the dynamic states of pulmonary ventilation and perfusion in bronchial asthmatics using (133)Xe gas ventilation scintigraphy and (99m)Tc-MAA lung perfusion scintigraphy kn-title=気管支喘息における換気血流動態の研究―(133)Xe換気シンチ及び(99m)Tc-MAA血流シンチによる検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the organic changes and pathophysiology of the lungs in intractable asthmatics, the dynamic states of pulmonary ventilation and perfusion were analyzed in 15 bronchial asthmatic in the stable state using (133)Xe gas ventilation scintigraphy and (99m)Tc-MAA lung perfusion scintigraphy, respectively. Dysfunction of pulmonary ventilation and impairment of pulmonary perfusin were significantly severer in intractable asthmatics than in non-intractable asthmatics (p<0.01, P<0.05, respectively) and those of asthma caused by aging. Late onset asthmatics with a long duration of disease tended to show severe impairment of pulmonary perfusion. Above all the longer the duration of the disease the severer became the impairment of pulmonary perfusion in late onset intractable asthmatics (LOIA). These findings suggest that the progression of irreversible organic changes of lungs in LOIA is involved in the severity of brochial asthma. en-copyright= kn-copyright= en-aut-name=IshihamaHidenobu en-aut-sei=Ishihama en-aut-mei=Hidenobu kn-aut-name=石濱英暢 kn-aut-sei=石濱 kn-aut-mei=英暢 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=中高年発症型難治性喘息 (LOIA) kn-keyword=中高年発症型難治性喘息 (LOIA) en-keyword=換気シンチ kn-keyword=換気シンチ en-keyword=血流シンチ kn-keyword=血流シンチ END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=353 end-page=364 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of lung cancer with interstitial pneumonia Part 2. Interleukin-2 receptor in peripheral blood of lung cancer patients kn-title=肺癌のびまん性肺線維化病態に関する研究　第2編　肺癌における末梢血インターロイキン 2 レセプターの検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Interleukin-2 receptor (IL-2R) and lymphocyte subsets in peripheral blood were evaluated in patients with lung cancer. The level of sluble IL-2R (sIL-2R) in sera and the percentage of IL-2R positive lymphocytes in lung cancer patients were higher than that in normal subjects, but the lymphocytes reactivity to IL-2 was not different from that in normal subjects. There was no difference in the IL-2/IL-2R system of each histological type in patients with lung cancer. The serum sIL-2R level and the percentage of IL-2R positive lymphocytes increased in the advenced stage, but lymphocyte reactivity to IL-2 decreased. There was dissociation between expression of IL-2R and lymphocyte reactivity to IL-2 in lung cancer patients. Furthermore, serum sIL-2R level increased in relation to progression of fibrotic changes in lung cancer with interstitial pneumonia, although the percentage of IL-2R positive lymphocytes did not increase. Serum sIL-2R level showed no correlation with the percentage of IL-2R positive lymphocytes. These data suggest that the increased level of sIL-2R may be related to fibrotic changes in the lung and reflect the disorder of cellular immunity in lung cancer patients with interstitial pneumonia. en-copyright= kn-copyright= en-aut-name=ShibayamaTakuo en-aut-sei=Shibayama en-aut-mei=Takuo kn-aut-name=柴山卓夫 kn-aut-sei=柴山 kn-aut-mei=卓夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Lung cancer kn-keyword=Lung cancer en-keyword=Soluble interleukin-2 receptor kn-keyword=Soluble interleukin-2 receptor en-keyword=Interleukin-2 receptor positive lymphocyte kn-keyword=Interleukin-2 receptor positive lymphocyte en-keyword=Response to recombinant human interleukin-2 kn-keyword=Response to recombinant human interleukin-2 en-keyword=Interstitial pneumonia kn-keyword=Interstitial pneumonia END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=341 end-page=351 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of lung cancer with interstitial pneumonia Part 1. Analysis of the clinical features of intersitial pneumonia in lung cancer kn-title=肺癌のびまん性肺線維化病態に関する研究　第1編　肺癌に随伴するびまん性間質性陰影の臨床的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical features and findings on chest x-ray were analyzed to clarify the relationship between lung cancer and interstitial pneumonia. Of 262 patients with lung cancer, 69 patients (26.3%) had interstitial pneumonia. Patients with interstitial pneumonia (LC with IP) were older than those without interstitial pneumonia (LC without IP). The incidence of LC with IP cases among males and smokers were 29.2% and 29.3%, respectively. There were no significant differences among histlogic types and clinical stages of lung cancer. More cases of LC with IP had cancer in the lower (42.0%) and peripheral (76.8%) areas on chest x-ray films. Cancer was frequently located within the interstitial shadow on chest x-ray film. Among 40 patients with idiopathic interstitial pneumonia associated lung cancer (IIP with LC), there were 38 males and 32 smokers. No dominant histlogic subtype of lung cancer was noted in IIP with LC, though the most frequent was adenocarcinoma (16 cases, 40%). In IIP with LC, the site of cancer was associated with active fibrotic changes in interstitial pneumonia. These data strongly suggest that carcinogenic factors were related to the fibrotic changes in interstitial pneumonia. en-copyright= kn-copyright= en-aut-name=ShibayamaTakuo en-aut-sei=Shibayama en-aut-mei=Takuo kn-aut-name=柴山卓夫 kn-aut-sei=柴山 kn-aut-mei=卓夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Lung cancer kn-keyword=Lung cancer en-keyword=Idiopathic interstitial pneumonia kn-keyword=Idiopathic interstitial pneumonia en-keyword=Chest X-ray finding kn-keyword=Chest X-ray finding END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=315 end-page=323 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of intractable asthman Part 2. Effect of Saiboku-to on lymphocyte function in the experimental asthma using guinea pigs kn-title=難治性喘息の治療に関する研究　第2編　モルモット喘息モデルにおけるリンパ球機能に対する柴朴湯の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Saiboku-to is a useful drug in the treatment of intractable asthmatics. The most important action mechanism of Saiboku-to seems to be a suppression on lymphocyte activation. The relationship between the in vitro and in vivo effects is not clear because the metabolism of Kampo medicine is unknown. Therefore, in this study two in vitro experimental systems were compared to evaluate the pharmacological effect of Saiboku-to on the lymphocyte blas-togenesis. The first system involved the addition of serum obtained from guinea pigs treated orally with Saiboku-to, while the second system involved the direct additon of the Saiboku-to extract to the medium. Saiboku-to has a suppressive effect on lymphocyte blastogenesis and also the metabolite of Saiboku-to had a suppressive effect. According to the formula based on these data, the serum level of Saiboku-to on oral administration of the common dose was assumed to be 5.65μg/ml in bronchial asthmatics. These findings suggest that Saiboku-to may an inhibitory effect in the cell-mediated allergic reaction by lymohocyte activation in vivo. en-copyright= kn-copyright= en-aut-name=OkamotoShoichi en-aut-sei=Okamoto en-aut-mei=Shoichi kn-aut-name=岡本章一 kn-aut-sei=岡本 kn-aut-mei=章一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Saiboku-to kn-keyword=Saiboku-to en-keyword=serum level kn-keyword=serum level en-keyword=actively sesitzed model kn-keyword=actively sesitzed model en-keyword=lymphocyte kn-keyword=lymphocyte END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=257 end-page=264 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Continuing benefits from spa therapy and environmental factors in patients with bronchial asthma kn-title=気管支喘息に対する温泉療法の遠隔成績と環境因子に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The relationship between continuing benefits from spa therapy to maintenance therapy (swimming training in a hot spring or hot water pool one to three times per week) and environmental factors was examined by a questionnaire sent to 60 patieints with bronchial asthma. The subjects had been patients at Misasa Branch Hospital and received spa therapy for one to three months. The efficacy rate of spa therapy ranged from 78 to 81%. In patients receiving maintenance therapy after discharge, continuing benefits from spa therapy were ovserbed for one year following therapy at our hospital, although the efficacy rate decreased as their environment worsened (air pollution). However, in patients with maintenance therapy, the influence of environmental factors was considerably less. In contrast, continuing benefits from spa therapy were very low in patients who did not receive maintenance therapy after discharge from our hospital. Continuing benefits were particularly diminishie in those living with air pollution. These results show that the continuing benefit of spa therapy on bronchial asthma is affected by maintenance therapy and environmental factors. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=2 ORCID= en-aut-name=OkazakiMorihiro en-aut-sei=Okazaki en-aut-mei=Morihiro kn-aut-name=岡崎守宏 kn-aut-sei=岡崎 kn-aut-mei=守宏 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=5 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name=杉本啓介 kn-aut-sei=杉本 kn-aut-mei=啓介 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=喘息 kn-keyword=喘息 en-keyword=温泉療法 kn-keyword=温泉療法 en-keyword=環境因子 kn-keyword=環境因子 en-keyword=遠隔成績 kn-keyword=遠隔成績 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=305 end-page=314 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the treatment of intractable asthman Part 1. Effect of Saiboku-to on cell-mediated allergy in the experimental asthma using guinea pigs kn-title=難治性喘息の治療に関する研究　第1編　モルモット喘息モデルにおける細胞反応型アルルギーに対する柴朴湯の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Saiboku-to seems to be a useful drug in the teatment of intractable asthmatics. The pharmacological effect of Saiboku-to was examined in an experimental model of bronchial asthma with cell-mediated allergy in guinea pigs. The fundings revealed that Saiboku-to inhibited the late asthmatic response. It suppressed the lymphocyte blastogensis by ascaris antigen and eosinophil infiltration into BALF and peribronchial tissue. Moreover, Saiboku-to lowered the levls of LTB4 and LTC4 in the cardiac blood, but not the antigen-specific IgG subclass. These findings suggest that the inhibitory effect of Saiboku-to on the late asthmatic response is caused by the suppression of cell-mediated allergy. en-copyright= kn-copyright= en-aut-name=OkamotoShoichi en-aut-sei=Okamoto en-aut-mei=Shoichi kn-aut-name=岡本章一 kn-aut-sei=岡本 kn-aut-mei=章一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Saiboku-to kn-keyword=Saiboku-to en-keyword=cell-mediated allergy kn-keyword=cell-mediated allergy en-keyword=actively sensitized model kn-keyword=actively sensitized model en-keyword=lymphocyte kn-keyword=lymphocyte en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=195 end-page=204 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism of late asthmatic response using a technique of bronchoalveolar lavage Part 2. Bronchial reaction after inhalation of Candida allergen in bronchial asthmatics kn-title=気管支喘息における遅発型気道反応の機序に関する研究　第2編　Candida 抗原による遅発型気道反応局所の細胞反応及びロイコトリエンの変動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the mechanism of late asthmatic response (LAR) which is related to intractable asthmatic attacks, cellular and humoral components at the sites of LAR were examined by bronchoalveolar lavage fluid (BALF) obtained after bronchial inhalation of Candida allergen. BAL examination was performed 2 hours after the LAR attack. The differential cell count was obtained and the level of leukotrienes (LTs) in the BALF and peripheral blood determined by high performance liquid chromatography. The percentages of eosinophils and basophil・mast cells and neutrophils were statistically high in the BALF after LAR compared with the level in the non-attack state (p<0.05 p<0.01). The level of LTC(4) was significantly higher in the BALF after LAR (p<0.01), and LTB(4) also showed a similar tendency at LAR. However, LTD(4) could not be detected in the BALF after LAR or in the non-attack stage. On the other hands, the percentage of neutorphils and LTB4 level in circulating blood showed a peak before LAR, and then decreased markedly during LAR. Eosinophils also decreased significantly during LAR, but the plasma LTC(4) level increased significantly during LAR. These findings suggest that neutrophils, eosinophils and basophil・mast cells play an important role in the pathogensis of intractable asthma attack and LAR following release of leukotrienes. en-copyright= kn-copyright= en-aut-name=NambaKunihiro en-aut-sei=Namba en-aut-mei=Kunihiro kn-aut-name=難波一弘 kn-aut-sei=難波 kn-aut-mei=一弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Candida antigen kn-keyword=Candida antigen en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage en-keyword=inflammatory cell kn-keyword=inflammatory cell en-keyword=late asthmatic response kn-keyword=late asthmatic response en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=185 end-page=193 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the mechanism of late asthmatic response using a technique of bronchoalveolar lavage Part 1. Bronchial reaction after inhalation of house dust mite allergen in bronchial asthmatics kn-title=気管支喘息における遅発型気道反応の機序に関する研究　第1編　House dust 抗原による遅発型気道反応局所の細胞反応及びロイコトリエンの変動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the mechanism of the late asthmatic response (LAR) which participates in intractable asthmatic attacks, humoral and cellular components at the sites of LAR were examined by bronchoalveolar lavage fluid (BALF) obtained after bronchial inhalation of house dust allergen. BAL examination was performed 2 hours after improvement of LAR, and leukotrienes (LTs) measured by high performance liquid chromatography. The level of LTC4 was significantly higher in BALF after LAR(p<0.05), and that of LTB4 was also high at LAR. The increase in the percentage of neutrophils, eosinophils and basophils were evident in BALF after LAR compared with the level in non-attack state and after IAR. However, little LTD4 was detected in the BALF after LAR. On the other hand, the percentage of neutrophils and the LTB4 level in peripheral blood showed a peak at 3 hours after bronchial inhalation of house dust allergen, and then decreased markedly during LAR. These findings suggest that neutrophils, eosinophils, and basophils may release leukotriene-dominant chemical mediators which provoke an asthmatic attack in the late phase response. en-copyright= kn-copyright= en-aut-name=NambaKunihiro en-aut-sei=Namba en-aut-mei=Kunihiro kn-aut-name=難波一弘 kn-aut-sei=難波 kn-aut-mei=一弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=House dust antigen kn-keyword=House dust antigen en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage en-keyword=inflammatory cell kn-keyword=inflammatory cell en-keyword=late asthmatic response kn-keyword=late asthmatic response en-keyword=leukotrienes kn-keyword=leukotrienes END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=231 end-page=238 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of Aspirin induced asthma Part 2. The clinical feature and sttack mechanism of Aspirin-induced asthma kn-title=アスピリン喘息の病態に関する研究　第2編　アスピリン喘息の臨床的並びに基礎的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical features and the attack mechanism of Aspirin-induced asthma (AIA) were studied in 31 AIA cases (9.3%) among 333 asthmatics. AIA was defined positve from the anamnesis or from a positive aspirin inhalation challenge test result. AIA had more severe asthma symptoms than non-AIA. Moreover. the frequency of nasal polyp in AIA patients was higher than that in non-AIA ones. To clarify the mechanism of AIA, the concentrations of plasma histamine and leukotrienes were measured before and after the aspirin inhalation challenge test. There was no difference in the plasma histamine leved between AIA and non-AIA patients. The concentrations of plasma histamine and leukotrienes were meaurred before and after addition of aspirin to the peripheral blood in vitro. There were no differnces in the plasma histamine or leukotriene levels between AIA and non-AIA patients. These findings suggest that the mast cell is less related to the mechanism of AIA. Therefore, it may be necessary to examine mediators other than histamine and leukotrienes. en-copyright= kn-copyright= en-aut-name=TsutsuiHideta en-aut-sei=Tsutsui en-aut-mei=Hideta kn-aut-name=筒井英太 kn-aut-sei=筒井 kn-aut-mei=英太 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=アスピリン kn-keyword=アスピリン en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=ヒスタミン kn-keyword=ヒスタミン en-keyword=ロイコトリエン kn-keyword=ロイコトリエン END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=127 end-page=134 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on anti-HTLV-T antibody in interstitial lung diseases Part 2. Anti-HTLV-TIgG, IgM, and IgA antibodies in HTLV-T associated bronchiolo-alveolar disorder (HABA) kn-title=間質性肺疾患における抗 HTLV-T抗体に関する研究　第2編 HTLV-T関連細気管支･肺胞異常症 (HABA) における抗 HTLV-TIgG, IgM, IgA 抗体に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To study the pathogenesis of HTLV-Tassociated bronchiolo-alveolar disorder (HABA), Western blot analysis was performed using MT-2 cell lysate antigens on the serum of 6 patients with HABA, 7 patients with adult T cell leukamia (ATL), 14 asymptomatic carriers and 9 healthy controls. Five(83%) of the 6 HABA patients were positive for anti-HTLV-T IgA antibodies, although all 7 ATL patients and 11 of the 14 asymptomatic carriers were negative. All HABA and ATL patients and asymptomatic carriers were positive for anti-HTLV-T IgG antibodies. Four(67%) of the 6 HABA patients, 2(29%) of the 7 ATL patients and 9(64%) of the 14 asymptomatic carriers were positive for anti-HTLV-T IgM antibodies. Statistically there was little difference in the incidences of anti-HTLV-T IgG and IgM antibodies among HABA and ATL patients and asymptomatic carriers, but the HABA patients showed a significantly higher incedence of IgA antibody than the ATL patients and asymptomatic carriers. Since specific IgA antibodies are produced in the local infected mucosa and part of the IgA antibodies are transferred into the serum, in conclusion, the anti-HTLV-T IgA antibodies in HABA patients reflect the localization of HTLV-T in lungs which play an important role in the pathogenesis of HABA. en-copyright= kn-copyright= en-aut-name=UenoKatsumi en-aut-sei=Ueno en-aut-mei=Katsumi kn-aut-name=植野克巳 kn-aut-sei=植野 kn-aut-mei=克巳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=HTLV-T関連細気管支・肺胞異常症 kn-keyword=HTLV-T関連細気管支・肺胞異常症 en-keyword=抗 HTLV-TIgA 抗体 kn-keyword=抗 HTLV-TIgA 抗体 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=119 end-page=126 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on anti-HTLV-T antibody in interstitial lung diseases Part 1. Western blot analysis for anti-HTLV-T antibody and HTLV-T related reaction in DBP and IIP kn-title=間質性肺疾患における抗 HTLV-T抗体に関する研究　第1編 DPB, IIPにおける抗 HTLV-T抗体並びに HTLV-T関連反応の Western blot 法による検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=By the immunofluorescent assay for the anti-HTLV-T antibody, the serum of many patients with diffuse panbronchiolitis (DBP) and idiopathic interstitial pneumonia (IIP) show two types of cytoplasmic fluorescence. One is a granular pattern in the MT-1 cell and diffuse pattern in the MT-2 cell. This is the typical pattern for the anti-HTLV-T antibody. The other is a diffuse pattern in the MT-1 and/or MT-2 cells. This pattern has been designated as HTLV-T related reaction. These serum reactions were investigated by Western blot analysis with an MT-2 cell lysate as antigen. Although about 20% of the patients with DBP and IIP were considered to be suffering from HTLV-T associated bronchiolo-alveolar disorder (HABA) because they showed the typical pattern of anti-HTLV-T antibody, only those patients with HABA were shown to have the antibodies against HTLV-T specific proteins (p19, p24, p28, pr53 and gp68). On the other hand, the patients with HTLV-T related reaction had neither the antibodies against any HTLV-T proteins nor the other protein components of MT-2. Thus, Western blot analysis revealed that antibodies against HTLV-T specific proteins were present only in the patients with HABA. en-copyright= kn-copyright= en-aut-name=UenoKatsumi en-aut-sei=Ueno en-aut-mei=Katsumi kn-aut-name=植野克巳 kn-aut-sei=植野 kn-aut-mei=克巳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=びまん性汎細気管支炎 kn-keyword=びまん性汎細気管支炎 en-keyword=特発性間質性肺炎 kn-keyword=特発性間質性肺炎 en-keyword=HTLV-T抗体 kn-keyword=HTLV-T抗体 en-keyword=HTLV-T関連反応 kn-keyword=HTLV-T関連反応 en-keyword=Western blot 法 kn-keyword=Western blot 法 END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=9-10 article-no= start-page=859 end-page=869 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ADF in the lung tissues of HTLV-I associated bronchiolo-alveolar disorder : HABA kn-title=HTLV-I 関連細気管支・肺胞異常症 (HABA) における肺組織中 ADF の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=ATL-derived factor (ADF) is an acid protein, molecular weight about 13KD, which is related to cell classification, activation, and various viral infections. The localization of ADF was studied in the lung tissues of HTLV-I associated bronchiolo-alveolar disorder : HABA, diffuse panbronchiolitis : DPB, and idiopathic interstitial pneumonia : IIP. The localization of ADF in the lung tissues was demonstrated by immunohistochemical staining with anti-ADF antibody as the first antibody, which was made by affinity purification. In all 4 cases of HABA, one of 6 cases of DPB, and two of 5 cases of IIP, staining of the lung tissue was positive. ADF was demonstrated in the bronchial epithelia, alveolar epithelia, vascular endothelia, and desquamative cells in HABA cases as the result of the study. ADF was also restrictively demonstrated in bronchial epithelia in DPB and IIP cases. The case of DPB in which ADF was demonstrated also showed positive HTLV-I related reaction. In conclusion, the localization of ADF in the lung tissues was demonstrated in HABA, DPB and IIP, suggesting immunological abnormalities based upon infections from HTLV-I or a related retrovirus. en-copyright= kn-copyright= en-aut-name=KitamuraTomoki en-aut-sei=Kitamura en-aut-mei=Tomoki kn-aut-name=北村智樹 kn-aut-sei=北村 kn-aut-mei=智樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=HTLV-I Associated Bronchiolo-alveolar Disorder : HABA kn-keyword=HTLV-I Associated Bronchiolo-alveolar Disorder : HABA en-keyword=ATL-derived factor : ADF kn-keyword=ATL-derived factor : ADF en-keyword=Diffuse panbronchiolitis kn-keyword=Diffuse panbronchiolitis en-keyword=Idiopathic interstitial pneumonia kn-keyword=Idiopathic interstitial pneumonia en-keyword=Anti HTLV-I antibody kn-keyword=Anti HTLV-I antibody END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=15 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of PIE syndrome Part 2. The analysis of allergic and immunological mechanisms in PIE syndrome using Aspergillus antigen kn-title=PIE症候群の病態に関する研究　第2編 PIE症候群における Aspergillus 抗原を中心とした免疫学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Various allergic and immunologic mechanisms have been postulated in the pathogenesis of PIE syndrome. In this study, the immune response to Aspergillus antigen was examined in patients with the PIE syndrome of allergic bronchopulmonary aspergillosis (ABPA) and those with aspergilloma to elucidate the immune mechanisms wihch regulate the pulmonary changes in PIE syndrome. The same Aspergillus species causes different clinical disease entities such as Aspergillus pneumonia, aspergilloma, ABPA and even hypersensitivity pneumonitis. The specific IgE against the Aspergillus antigen for the type T allergy existed in patients with ABPA but not in those with Aspergilloma. However, the prepicitating antibody for the type V allergy and enhanced lymphocyte blastogenesis against Aspergillus antigen for the type W allergy were found in both the patients with ABPA and those with aspergilloma while pulmonary infiltration, dyspnea and the grade of peripheral eosinophilia correlated with the level of serum IgE and responsiveness of lymphocyte against Aspergillus antigen. These findings indicate that the characteristics of the immune responses of the host play a crucial role in the pathogenesis of PIE syndrome. en-copyright= kn-copyright= en-aut-name=SatoKyo en-aut-sei=Sato en-aut-mei=Kyo kn-aut-name=佐藤恭 kn-aut-sei=佐藤 kn-aut-mei=恭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Allergic bronchopulmonary aspergillosis kn-keyword=Allergic bronchopulmonary aspergillosis en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage en-keyword=lymphocyte blastogenesis kn-keyword=lymphocyte blastogenesis en-keyword=PIE syndrome kn-keyword=PIE syndrome END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of PIE syndrome Part 1. Evaluation of cellular responses in bronchoalveolar lavage fluid of patients with PIE syndrome kn-title=PIE症候群の病態に関する研究　第1編 PIE症候群の肺局所細胞反応の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The bronchoalveolar lavage (BAL) fluid of patients with PIE syndrome characterized by pulmonary eosinophilia was examined to determined the cellular response in the lungs. Evaluation of cellular components in the BAL fluid revealed an increased proportion not only of eosinophils but also of lymphocytes and neutrophils. In about half of the patients with PIE syndrome the level of eosinophilia was higher in the peripheral blood than in the BAL fluid. Patients with PIE syndrome were classified into prolonged PIE and PIE with asthma based on Crofton's classification. The percentage of neutorphils and eosinophils in BAL fluid were higher in patients with prolonged PIE than in PIE with asthma while the percentage of lymphocytes was higher in a group of PIE with asthma. On the other hand, the lymphocyte precentage in BAL fluid was higher in patients with PIE syndrome due to fungus antigen than in those with PIE syndrome due to drug allergy. These findings suggest that various cellular components play important roles in the pathogenesis of PIE syndrome and that the accumulation of the effector cells in the lungs is regulated by an allergic mechamism. en-copyright= kn-copyright= en-aut-name=SatoKyo en-aut-sei=Sato en-aut-mei=Kyo kn-aut-name=佐藤恭 kn-aut-sei=佐藤 kn-aut-mei=恭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage en-keyword=PIE syndrome kn-keyword=PIE syndrome en-keyword=eosinophil kn-keyword=eosinophil en-keyword=lymphocyte kn-keyword=lymphocyte en-keyword=neutrophil kn-keyword=neutrophil END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=7-8 article-no= start-page=759 end-page=770 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=199308 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of anti-IgE autoantibody in bronchial asthma kn-title=気管支喘息における血清抗 IgE 自己抗体の基礎的並びに臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogenesis of asthma especially intractable asthma, we measured the serum levels of anti-IgE autoantibody in 46 asthmatics and 39 healthy subjects, using solid-phase enzyme immunoassay. The serum levels of anti-IgE autoantibody in bronchial asthmatics were significantly higher than those in healthy subjects (p<0.01). The levels of anti-IgE autoantibody in 25 atopic asthmatics were also significantly higher than those in 19 non-atopic asthmatics (p<0.01). Futhermore, significant correlation was observed between the levels of anti-IgE autoantibody and serum IgE (r=0.576, p<0.01). House dust and Candida (p<0.01) specific IgE (RAST) positive asthmatics also tended to have higher serum levels of anti-IgE autoantibody. However, no significant relation was observed between the serum levels of anti-IgE autoantibody and the severity of asthma. Moreover, anti-IgE autoantibody was not significantly related to specific IgG subclass antibody or lymphocyte blastogenesis to mite and Candida, or with the numbers of eosinophils and basophils in peripheral blood. These findings suggest that anti-IgE autoantibody play an important role in the pathogenesis of bronchial asthma, especially atopic asthma associated with IgE-dependent mechanisms. en-copyright= kn-copyright= en-aut-name=YamagataKoichi en-aut-sei=Yamagata en-aut-mei=Koichi kn-aut-name=山縣浩一 kn-aut-sei=山縣 kn-aut-mei=浩一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=抗 IgE 自己抗体 kn-keyword=抗 IgE 自己抗体 en-keyword=アトピー型喘息 kn-keyword=アトピー型喘息 en-keyword=IgE 抗体 kn-keyword=IgE 抗体 en-keyword=IgG アイソタイプ抗体 kn-keyword=IgG アイソタイプ抗体 en-keyword=酵素抗体法 kn-keyword=酵素抗体法 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=145 end-page=162 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinicopatholgical studies on htpersensitivity pneumonitis : Cellular kinetics in bronchoalveolar lavage (BAL) fluid of the patients with hypersensitivity pneumonitis kn-title=過敏性肺臓炎の病態に関する研究ー気管支肺胞洗浄液中の細胞動態を中心にー en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cellular components of bronchoalveolar lavage (BAL) fluids from 26 patients with hypersensitivity pneumonitis were analyzed with regard to the period of antigen exposure before BAL procedure. In the early phase of antigen exposure BAL fluids contained increased neutrophils as well as lymphocytes while a low percentage of neutrophils and a prominent increase of lymphocytes were observed in chronic antigen exposure. Furthermore, the in-creased neutrophils decreased rapidly after cessation of antigen exposure while lymphocytes decreased gradually. In the BAL fluids of patients with summer-type hypersensitivity pneumonitis, CD4+ percentages and CD4/CD8 rations were significantly decreased, but CD8+ percentages significantly increased during antigen exposure compared with that in healthy controls. However, the actual CD4+ cell counts in BAL fluids significantly increased while CD4+ percentage decreased. Thus, CD4+ as well as CD8+ may play important roles in the pathogenesis of hypersensitivity pneumonitis. Soluble IL-2 receptor (sIL-2R) levels in BAL fluids and serum obtained from patients with hypersensitivity pneumonitis, especially serum sIL-2R during the active phase, were signifi-cantly higher than those of normal controls, indicating that the elevated sIL-2R level reflect-ed a highly activated immune response. In relation to pulmonary fuction, the lympocyte percentage showed a significant inverse correlation with % TLC and PaCO2, while neutrophil percentage showed significant correlation with % TLC and inverse correlation with FEV 1.0%. These reaults suggest that neutrophilia in BAL fluids affects bronchobronchiolar disorders during the early phase, and lympocytosis in BAL fluids regulates organic changes of the lung in hypersensitivity pneumonitis. en-copyright= kn-copyright= en-aut-name=KajimotoKazuhiro en-aut-sei=Kajimoto en-aut-mei=Kazuhiro kn-aut-name=梶本和宏 kn-aut-sei=梶本 kn-aut-mei=和宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=過敏性肺臓炎 kn-keyword=過敏性肺臓炎 en-keyword=気管支肺胞洗浄法 kn-keyword=気管支肺胞洗浄法 en-keyword=Tリンパ球サブセット kn-keyword=Tリンパ球サブセット en-keyword=吸入誘発試験 kn-keyword=吸入誘発試験 en-keyword=肺機能 kn-keyword=肺機能 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=9-10 article-no= start-page=1025 end-page=1033 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A new asthma classification based on its pathophysiology using IgE antibody (RAST) and lymphocyte activation as parameters kn-title=気管支喘息における病態に基づく新しい病型分類に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To establish a new classification in bronchial asthma, antigen-induced immediate asthmatic response (IAR) and late asthmatic response (LAR) to mite and Candida were compared with antigen specific IgE antibody (IgE RAST) and lymphocyte blastogenesis (Ly-BL) in asthmatics. Half of asthmatics with a high score on mite IgE RAST could not be provoked to IAR, although almost all of patients with house dust-induced IAR showed a high score on mite IgE RAST. However, asthmatics with enhanced Ly-BL following exposure to mite and Candida showed highly provoked LAR by antigen inhalation, and LAR patients showed significantly enhanced Ly-BL by both antigens (p<0.01). Bronchial asthmatics were classified into the following 4 groups using those parameters ; A group (IgE RAST+, Ly-BL-), B group (IgE RAST+, Ly-BL+), C group (IgE RAST-, Ly-BL+), D group (IgE RAST-,Ly-BL-). Half of the patients with IAR belonged to the A and B groups, and almost all of the LAR patients were in the B or C group. Patients in the A group predominantly showed early onset, however patients in the B and C groups showed late onset. A and B group patients were mild or moderate asthmatics, but severe asthmatics belonged to the C and D groups. These data suggest that the C group showed only Ly-BL led LAR by "cell-mediated allergy" in late onset severe asthma. en-copyright= kn-copyright= en-aut-name=KimuraKazuhi en-aut-sei=Kimura en-aut-mei=Kazuhi kn-aut-name=木村和陽 kn-aut-sei=木村 kn-aut-mei=和陽 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=asthma classification kn-keyword=asthma classification en-keyword=lymphocyte blastogenesis kn-keyword=lymphocyte blastogenesis en-keyword=Candida kn-keyword=Candida en-keyword=house dust・mite kn-keyword=house dust・mite en-keyword=IgE RAST kn-keyword=IgE RAST END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=9-10 article-no= start-page=1013 end-page=1024 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199410 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Detection of plasma kallikrein in the bronchoalveolar lavage fluid of asthmatic subjects and its origin kn-title=気管支喘息患者の気管支肺胞洗浄液上清(BALF)中のカリクレイン様活性物質の同定とその由来に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Plasma kallikrein was detected in bronchoalveolar lavage fluid (BALF) obtained from bronchial asthma patients and compared to that of normal adults. Characterization using chromogenic substrates S-2302, S-2266, S-2222, and using inhibitors SBTI, Trasyrol, DIFP, suggested that the amidolytic activity in BALF from bronchial asthma patients was compatible with plasma kallikrein. Using immunoblotting method with specific antibody, we concluded that the plasma kallikrein-like activity in BALF was surely plasma kallikrein itself. The plasma kallikrein activity in BALF obtained from patients with late asthmatic response (LAR) was significantly higher than that in fluid from patients with immediate asthmatic response (IAR). Kininogenase activity was also detected by cleavage of bradykinin from acid-treated plasma. To investigate whether the plasma kallikrein in BALF originated from human lung mast cell or basophil, the supernatant of lung mast cells and that of basophils were tested using three chromogenic substrates and the immunoblotting method. We conculuded that the plasma kallikrein in BALF did not originate from lung mast cells or basophils. These results suggested that elevated amounts of plasma kallikrein in BALF of patients with LAR might contribute to the pathogenesis and modification of LAR. en-copyright= kn-copyright= en-aut-name=FujitaToshiaki en-aut-sei=Fujita en-aut-mei=Toshiaki kn-aut-name=藤田敏明 kn-aut-sei=藤田 kn-aut-mei=敏明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=bronchoalveolar lavage fluid kn-keyword=bronchoalveolar lavage fluid en-keyword=plasma kallikrein kn-keyword=plasma kallikrein en-keyword=immunoblotting method kn-keyword=immunoblotting method en-keyword=basophil and mast cell kn-keyword=basophil and mast cell END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=83 end-page=92 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Circulating eosinophil and basophil precursor cells in bronchial asthmatics kn-title=気管支喘息患者における末梢血中の好酸球・好塩基球前駆細胞の動態の関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogensis of bronchial asthma, eosinophil and basophil precursor cells in peripheral blood were investigated in 28 patients with bronchial asthma (20 atopic and 8 non-stopic asthmatics) and 6 healthy subjects using in vitro colong forming assay with methylcellulose culture medium. There was no significant difference between the mean count of Eo-type colony in bronchial asthmatics and that in healthy subjects, although cases with high colony were more common in the asthma group. The Eo-type colony count was significantly higher in atopic asthmatics than in either non-atopic astmatics or healthy subjects. In contrast, the colony count in non-atopic asthmatics was significantly lower than that in healthy subjects. A significant correlation was found between the Eo-type colony count and peripheral blood eosinophil count in atopic asthmatics, but there was no correlation between the conlony count and peripherad blood basophil count. These finidings suggest that circulating eosinophil and basophil precuresor cells play an important role in the pathogenesis of atopic bronchial asthma. en-copyright= kn-copyright= en-aut-name=ArakiMasashi en-aut-sei=Araki en-aut-mei=Masashi kn-aut-name=荒木雅史 kn-aut-sei=荒木 kn-aut-mei=雅史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=eosinophil kn-keyword=eosinophil en-keyword=basophil kn-keyword=basophil en-keyword=colony kn-keyword=colony en-keyword=precursor cell kn-keyword=precursor cell END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=907 end-page=915 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Establishment of antigen specific T cell clones from asthmatic patients including evaluation of cytokine production kn-title=気管支喘息における抗原特異的 T cell clone の樹立とサイトカイン産生能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the pathogenesis of bronchial asthma, we establishied T cell clones specific for Candida antigen and for mite antigen from the peripheral blood of three asthmatic patients. Flow cytometric analysis was performed on these clones. The surface phenotype of all clones was helper/inducer type. These clones were analyzed for the ability to produce interferon gammma (IFN-γ) and interleukin 4 (IL-4). The T cell clone established from tne patient who showed late asthmatic response (LAR) after bronchial inhalation of Candida, as well as the clones from the patient who showed IAR and LAR after inhalation of housedust mite, produced a higher amount of IFN-γ and lower amount of IL-4. The T cell clone established from the patient who were under corticosteroid therapy and showed IAR after inhalation of Candida produced lower amounts of IFN-γ and IL-4, which seemed to be inhibition of cytokine production from antigen specific T cell clone by corticosteroids. These findings indicate that T cell clones established from the patients who showed LAR produced a large amount of IFN-γ, suggesting that IFN-γ plays an important role in allergic reactions of LAR. en-copyright= kn-copyright= en-aut-name=MiyaharaNobuaki en-aut-sei=Miyahara en-aut-mei=Nobuaki kn-aut-name=宮原信明 kn-aut-sei=宮原 kn-aut-mei=信明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=antigen specific T cell clone kn-keyword=antigen specific T cell clone en-keyword=IFN-γ kn-keyword=IFN-γ en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=late asthmatic response (LAR) kn-keyword=late asthmatic response (LAR) END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=71 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the soluble interleukin-2 receptor in patients with bronchial asthma kn-title=気管支喘息におけるInterleukin-2 receptorに関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cytokine-mediated interactions among blood cells, especially T-lymphoctes, may be impor-tant in the regulation of airway inflammation in asthma. To investigate whether T-lymphocytes are related to disease activity in asthma, serum soluble interleukin-2 receptor (sIL-2R) levels were measured in 77 bronchial asthmatics and 19 healthy volunteers. The serum sIL-2R level was higher in asthmatics than in healthy controls (mean±SD ；449.8±225.5 vs. 323.2±123.9 U/ml ; p<0.01). However, sIL-2R levels were similar between atopic and non-atopic asthmatics (451.9±235.9 vs. 416.7±147.2 U/ml), and were also similar between severe and mild to moderate asthmatics (437.4±209.9 vs. 469.8±276.1 U.ml). Steroid-dependent intractable asthmatics treated with prednisolone st doses of 5-10 mg/day showd higher sIL-2R levels (470.1±257.9 U/ml) than asthmatics treated with the drug at doses below 5 mg/day (357.2±102.6 U/ml) and intractable asthmatics treated with the drug at doses above 10 mg/day (282.5±194.5 U/ml). There was a strong correlation (r=0.915 ; p<0.01) between percentage at IL-2R-positive helper T cells among peripheral white blood cells and the serum concentration of sIL-2R. The type W cell-mediated immune response is considered to be related to the pathogenesis of asthman. Serum sIL-2R levels are thought to reflect the extent of T-lymphocyte activation in non-malignant disease, but the level is aiso influenced by steroid therapy. en-copyright= kn-copyright= en-aut-name=KozukaAkiko en-aut-sei=Kozuka en-aut-mei=Akiko kn-aut-name=小塚明子 kn-aut-sei=小塚 kn-aut-mei=明子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=難治性喘息 kn-keyword=難治性喘息 en-keyword=T細胞 kn-keyword=T細胞 en-keyword=IL-2R kn-keyword=IL-2R en-keyword=細胞反応型アレルギー kn-keyword=細胞反応型アレルギー END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=883 end-page=892 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Xanthoma cells in sputa of patients with chronic obstructive lung diseases kn-title=慢性閉塞性肺疾患における喀痰中 Xanthoma cell に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Alveolar macrophages attack various foreign bodies inspired through the airway and destroy cell debris. Furthermore, a part of the surfactant produced by alveolar epithelium would be phagocytized by alveolar macrophages forming foamy cells in lung tissue. These formy cells could be detected by oil red O staining as xanthoma cells in sputa of patients with airway diseases. Therefore, xanthoma cells in sputa of patients with DPB, chronic bronchitis and bronchial asthma were evaluated to clarify the role in the pathogenesis of these respiratory diseases. All patients with DBP expectorated enormous amounts of xanthoma cells in sputa while 88% of the patients with chronic bronchitis and 41% of those with bronchial asthma had sputa containing xanthoma cells in a smaller number than DBP. Increased xanthoma cells were shown in DPB with longer disease duration, lower vital capacity, lower atrerial blood oxygen pressure, and pseudomonas infection. However, extreme obstruction of small airway diminished xanthoma cells in sputa. Xanthoma cells were shown in bronchial asthma especially in late onset and intractable asthmatics. These findings indicate that xanthoma cells in sputa reflect the existence of organic changes in the small airway which disturb the drainage of surfactant from alveolar area to bronchial trees. en-copyright= kn-copyright= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=びまん性汎細気管支炎 kn-keyword=びまん性汎細気管支炎 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=喀痰 kn-keyword=喀痰 en-keyword=oil red O 染色 kn-keyword=oil red O 染色 en-keyword=xanthoma cell kn-keyword=xanthoma cell END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=61 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interleukin-2 receptor α(p55) mRNA expression in alveolar lymphocytes of patients with sarcoidosis kn-title=サルコイドーシス患者肺胞リンパ球のInterleukin-2 receptor α(IL-2R α) mRAの発現に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=T-lymphocytosis was detected in bronchoalveolar lavage fluid of patients with sarcoidosis. To clarify the mechanism of this phenomenon, interleukin-2 receptor(IL-2R) α gene expres-sion of lymphocytes recovered from bronchoalveolar lavage fluid was investigated in 8 patients with sarcoidosis and 5 healthy individuals, using reverse transcription polymerase chain reactin (RT-PCR). Cytoplasmic RNA derived from alveolar lymphocytes was reverse transcribed by RAV-2 reverse transcriptase to cDNA. The cDNA produced by reverse transcription was subjected to PCR. The primers of IL-2R α were utilized and a template derived from IL-2R mRNA was amplified by PCR. Southern blot analysis using 32P labeled cDNA probe for IL-2R α was performed followed by PCR. The intensities of IL-2R mRNA expression in Southern blot analysis were closely correlated to the cell numbers determined in RT-PCR. All patients with sarcoidosis had higher expression of IL-2R α mRNA transcript in alveolar lymphoctes compared with healty with healthy individuals. Moreover, the expression increased after stimulation by Propionibacterium acnes in 5 of 6 patents with sarcoidosis. These findings suggest that alvalar T-lymphocytes in the patients with sarcoidosis were actiated and played a central role in the pathogenesis of sarcoidosis. en-copyright= kn-copyright= en-aut-name=NishizakiHiroshi en-aut-sei=Nishizaki en-aut-mei=Hiroshi kn-aut-name=西崎浩 kn-aut-sei=西崎 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=sarcoidosis kn-keyword=sarcoidosis en-keyword=interleukin-2 receptor α kn-keyword=interleukin-2 receptor α en-keyword=reverse transcription-polymerase chain reaction kn-keyword=reverse transcription-polymerase chain reaction en-keyword=alveolar lymphocyte kn-keyword=alveolar lymphocyte en-keyword=Propionibacterium acnes kn-keyword=Propionibacterium acnes END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=847 end-page=860 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The mechanism of human basophil activation through the low affinity IgG receptor (Fc γ RU) : Analysis of calcium mobilization using a new flow cytometric method kn-title=低親和性 IgG レセプター（FcγRU）を介するヒト好塩基球の活性化機序に関する研究―フローサイトメーターによるカルシウム動態の解析― en-subtitle= kn-subtitle= en-abstract= kn-abstract=A new method for flow cytometric analysis of calcium mobilization in human peripheral blood basophils without prior purification was developed. The method is based on dual color analysis of centrifugation-enriched mononuclear cell populations using fluo-3 and phycoerythrin (PE)-conjugated CD2, CD14, CD16, CD19 monoclonal antibodies (mAb) to stain contaminated cells. This technique allows the detection of fluo-3 fluorescence as a measure of an increase in the cytoplasmic free calcium concentration ([Ca(2+)]i) while simulataneously discriminating PE-mAb-unlabelled basophils. To clarify whether the human peripheral blood basophil is activated through the low affinity IgG receptor, Fc γ RU, as well as the high affinity IgE receptor, Fc ε　RT, calcium mobilization after Fc γ RU stimulation was analyzed by this method. After cross-linking of Fc γ RU, transient [Ca(2+)]i elevation was observed but there was no apparent difference with interleukin-3(IL-3)-treated cells, and no significant histamine release was observed with or without short pre-incubation of IL-3. These findings suggest that the cross-linking of Fc γ RU, not only Fc ε　RT, can activate human basophils which may result in mediator release other than histamine. en-copyright= kn-copyright= en-aut-name=SuwakiToshimitsu en-aut-sei=Suwaki en-aut-mei=Toshimitsu kn-aut-name=洲脇俊充 kn-aut-sei=洲脇 kn-aut-mei=俊充 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=basophils kn-keyword=basophils en-keyword=FcγRU kn-keyword=FcγRU en-keyword=fluo-3 kn-keyword=fluo-3 en-keyword=Ca(2+) mobilization kn-keyword=Ca(2+) mobilization END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=51 end-page=60 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The production of platelet activating factor (PAF) from neutrophils in bronchial asthmatics kn-title=気管支喘息における血小板活性化因子の役割に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It was recently suggested that chemical mediators such as leukotrienes and PAF are more important in the pathogenesis of bronchial asthma than histamine. In this study, to clarify the role of PAF in bronchial asthma, I measured PAF activity derived from human neutrophils by the platelet aggregation tachnique and evaluated this activity in relation to the clinical features of brochial asthma. Neutrophils were separated from heparinized venous blood of 34 bronchial asthmatics and 11 healthy subjects. After suspension at 6×10(6) cells/ml, the cells were treated with 5μg/ml Ca ionophore A23187 for 5 minutes. PAF was extracted from the cell suspension using chloroform, and the activity was measured with an aggregometer using rabbit platelets. PAF activaty was significantly higher (p<0.05) in asthmatics (8.3±6.9 pmol/1×10(6) cells) than in healthy subjects (4.1±3.2 pmol/1×10(6) cells), and tended to increase in steroid-independent asthmatics rather than in steroid-dependent asthma patients. However, there was no difference in PAF production between atopic and non-atopic asthmatics, or between the early and late onset asthmatics. PAF production was increased in patients with severe airway hypersensitivity. These finding suggest that PAF plays an important role in the development and exacerbation of asthma. en-copyright= kn-copyright= en-aut-name=TsujiMitsuaki en-aut-sei=Tsuji en-aut-mei=Mitsuaki kn-aut-name=辻光明 kn-aut-sei=辻 kn-aut-mei=光明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=気管支喘息 kn-keyword=気管支喘息 en-keyword=血小板活性化因子 kn-keyword=血小板活性化因子 en-keyword=好中球 kn-keyword=好中球 END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=825 end-page=835 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The role of eicosanoids in airway hyperresponsiveness of chronic asthma using an animal model kn-title=連日抗原吸入による実験的慢性喘息におけるEicosanoidsの役割に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To elucidate the cause of severe asthma in adults, an animal model of chronic asthma was established in guinea pig sensitized by intraperitoneal injection of Ascaris suum and inhalation of the antigen repeated ten times. Then airway hyperresponsiveness, inflammatory cells and eicosanoids in the bronchoalveolar lavage fluid (BALF) and peripheral blood were examined. Airway responsiveness was acquired after inhalation of the antigen. Two types of airway responsiveness were observed ; accerelating-group and recovering-group. Total cell count and numbers of eosinophils and neutrophils in the BALF were significantly increased in the accerelating-group compared with the recovering-group and the control-group. The TXB2 level in the BALF was increased in the accerelating-group, and the LTB4 level in the BALF and peripheral blood were also increased in the accerelating-group. These findings suggest that the airway hyperresponsiveness is caused by eicosanoids, such as thromboxanes and leukotrienes produced by some inflammatory cells which are organized by activated lymphocytes as well as mast cell-basophils. en-copyright= kn-copyright= en-aut-name=TsujiAkihito en-aut-sei=Tsuji en-aut-mei=Akihito kn-aut-name=辻晃仁 kn-aut-sei=辻 kn-aut-mei=晃仁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Ascaris suum kn-keyword=Ascaris suum en-keyword=guinea pig kn-keyword=guinea pig en-keyword=eicosanoids kn-keyword=eicosanoids en-keyword=chronic asthma kn-keyword=chronic asthma en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=1-2 article-no= start-page=23 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=T-cell subsets in lung tissue and BALF from patients with interstitial pneumonia kn-title=各種間質性肺疾患における BAL 液並びに肺組織中 T-cell subset の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The cellular components in bronchoalveolar lavage fluids (BALF) and biopsied lung tissues of patients with various types of interstitial pneumonia were analyzed to clarify cellular kinetics in the lung. The T-cell subsets of lymphocytes in BALF and biopsied lung tissues were examined in 7 cases of hypersensitivity pneumonitis (HP), 2 cases of sarcoidosis (Sar), one case of idiopathic interstitial pneumonia (IIP) and 2 cases of rheumatoid arthritis with interstitial pneumonia (RA+IP). The T-cell subsets in BALF were analyzed by flow cytometry and the T-cell subsets in lung tissue were detected in frsh frozen and thin-sliced specimens using an avidine-biotine complex (ABC) kit. The mean CD4/CD8 ratio in BALF was 0.36 in HP, 3.1 in Sar, 1.07 in IIP and 2.59 in RA+IP, while the mean CD4/CD8 ratio in lung tissues was 0.52 in HP, 2.59 in Sar, 1.11 in IIP and 2.25 in RA+IP, respectively. The ratios of CD4/CD8 in BALF and lung tissues from patients with these various interstitial pneumonia showed a positive correlation. Significant correlation was seen between CD4/CD8 rations of the alveolar portion findings indicate that BAF findings reflect the changes in the lung tissues, although BALF might reflect only a part of the changes in the whole lung. en-copyright= kn-copyright= en-aut-name=NambaJiro en-aut-sei=Namba en-aut-mei=Jiro kn-aut-name=難波次郎 kn-aut-sei=難波 kn-aut-mei=次郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchoalveolar lavage (BAL) kn-keyword=bronchoalveolar lavage (BAL) en-keyword=transbronchial lung biopsy (TBLB) kn-keyword=transbronchial lung biopsy (TBLB) en-keyword=immunoperoxidase staining kn-keyword=immunoperoxidase staining en-keyword=T-cell subset kn-keyword=T-cell subset END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=789 end-page=798 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Human T-lymphotropic virus type-Tinfection and pulmonary fibrosing changes in patients with lung cancer kn-title=肺癌患者における HTLV-T感染と間質性肺病変に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Thirty-one patients with lung cancer in Okinawa known as HTLV-Tendemic area, and 140 patients in Okayama were evaluated in regard to HTLV-Tinfection and iterstitial pulmonary shadows. The presence of HTLV-Tinfection was examined by the polymerase chain reaction (PCR) method in peripheral blood mononuclear cells, and indirect immunofluorescent (IF) assay in sera. Interstitial pulmonary shadows on the chest roentgenograph, were classified according to the grade of fibrosis. The rate of HTLV-Tinfection in patients with lung cancer was higher than that in healthy controls by IF assay in both districts. The rate of anti-HTLV-Tantibody was higher in lung cancer patients with severe fibrosis than in those with milder fibrosis, but the grade of fibrosis and existence of pX gene had no relation in Okinawa or in Okayama. The incidence of patients with anti-HTLV-Tantibody was higher in patients with adenocarcinoma and squamous cell carcinoma than in those with small cell carcinoma. These findings suggested that HTLV-Tinfection was closely involved in some patients with non-small cell lung cancer having intersitital pulmonary shadows. en-copyright= kn-copyright= en-aut-name=NanbaSeiji en-aut-sei=Nanba en-aut-mei=Seiji kn-aut-name=難波靖治 kn-aut-sei=難波 kn-aut-mei=靖治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=肺癌 kn-keyword=肺癌 en-keyword=びまん性間質性肺病変 kn-keyword=びまん性間質性肺病変 en-keyword=polymerase chain reaction kn-keyword=polymerase chain reaction en-keyword=間接蛍光抗体法 kn-keyword=間接蛍光抗体法 en-keyword=HTLV-T kn-keyword=HTLV-T END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=743 end-page=750 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the occurrence of bronchial asthma Part 2. Lymphocytes activated by Cytomegalovirus kn-title=気管支喘息の発症に関する研究　第2編　喘息患者におけるサイトメガロウイルス抗原によるリンパ球幼若化反応の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The possible role of virus infection in the occurrence and attack of asthma was examined by measuring the lymphocyte transformation test to CMV in 44 asthmatic and 14 healthy subjects and analyzed their relation to the clinical parameters. CMV-induced lymphocyte reactivity (CMV-LR) in adult asthmatics was significantly higher than that in the healthy controls. A positive correlation was observed between CMV-LR titer and CMV-complement fixation (CMV-CF) antibody titers (r=0.35). In adult asthmatics, the CMV-LR in the high IgE titer (100U/ml≦) group was significantly higher than that in the low IgE titer (<100U/ml) group. These findings suggest that CMV is an important factor in the pathogenesis of adult asthma mediated by lymphocytes and probably IgE, although the precise mechanism in still unknown. en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=bronchial asthma kn-keyword=bronchial asthma en-keyword=viral infection kn-keyword=viral infection en-keyword=Cytomegalovirus kn-keyword=Cytomegalovirus en-keyword=IgE kn-keyword=IgE en-keyword=CMV-LTT kn-keyword=CMV-LTT END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=149 end-page=154 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of Mirizzi's syndrome with abnormal branched cystic duct managed by extracorporeal shock wave lithotripsy and endoscopic sphincterotomy kn-title=体外衝撃波結石破砕術と内視鏡的乳頭切開術により治癒せしめた胆?分岐異常を呈した Mirizzi 症候群の一例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report a case of Mirizzi's syndrome managed by extracorporeal shock wave lithotripsy and endoscopic sphincterotomy. An 84-year-old man who was suspected of choledocholithiasis but preferred non surgical treatment was transfered to our hospital. The stone impacted in the dilated cystic duct was removed by endoscopic sphincterotomy after fragmentation by extracorporeal shock wave lithotripsy. Endoscopic retrograde cholangiography revealed that the dilated cystic duct branched into the lower common hepatic duct. Long-term results should be assessed carefully, but extracorporeal shock wave lithotripsy in combination with endoscopic sphincterotomy for Mirizzi's syndrome should be actively attempted because it is a non-invasive and effective technique. en-copyright= kn-copyright= en-aut-name=TakaiKenichi en-aut-sei=Takai en-aut-mei=Kenichi kn-aut-name=高井研一 kn-aut-sei=高井 kn-aut-mei=研一 aut-affil-num=1 ORCID= en-aut-name=KunitomiMie en-aut-sei=Kunitomi en-aut-mei=Mie kn-aut-name=国富三絵 kn-aut-sei=国富 kn-aut-mei=三絵 aut-affil-num=2 ORCID= en-aut-name=OhtaSachiko en-aut-sei=Ohta en-aut-mei=Sachiko kn-aut-name=大田祥子 kn-aut-sei=大田 kn-aut-mei=祥子 aut-affil-num=3 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=4 ORCID= en-aut-name=KuroseMasao en-aut-sei=Kurose en-aut-mei=Masao kn-aut-name=黒瀬距Y kn-aut-sei=黒瀬 kn-aut-mei=距Y aut-affil-num=5 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山中央病院内科 affil-num=2 en-affil= kn-affil=岡山中央病院内科 affil-num=3 en-affil= kn-affil=岡山中央病院内科 affil-num=4 en-affil= kn-affil=岡山中央病院外科 affil-num=5 en-affil= kn-affil=岡山中央病院外科 affil-num=6 en-affil= kn-affil=岡山中央病院外科 en-keyword=Mirizzi 症候群 kn-keyword=Mirizzi 症候群 en-keyword=ESWL kn-keyword=ESWL en-keyword=EST kn-keyword=EST END start-ver=1.4 cd-journal=joma no-vol=108 cd-vols= no-issue=3-6 article-no= start-page=117 end-page=127 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960629 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Erythromycin therapy in patients with diffuse panbronchiolitis kn-title=びまん性汎細気管支炎の病態に関する研究―エリスロマイシン少量長期投与を中心に― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Low dose and long-term erythromycin (EM) therapy showed obvious improvement of symptoms and prognosis in patients with DPB. However, mechanisms involved in these clinical effects of EM therapy remain controversial. In this study, the clinical effects of EM therapy on respiratory function, bacterial flora in the lower airway and serum levels of soluble IL-2 receptor (sIL-2R) as an indicator of T-cell activation were examined. All parameters of respiratory functions in patients with DPB including % VC, % FEV 1.0, % V50, % V25 and V50/V25 showed marked improvements within 6 months of EM therapy. Continuous administration of EM for 6 to 24 months produced minimal changes in these respiratory functions though decreases in some parameters were observed in patients with advanced clinical stage and in eldely patients. The increase of % FEV 1.0 exceeded those of % V50 and % V25 after EM therapy. This indicates severe pathological changes in small airways or variable effects of EM therapy. Bacterial species and sensitivities to antibiotics showed no apparent changes after long-term EM therapy. The serum levels of sIL-2R in patients with DPB were higher than those in normal controls. With EM therapy, serum levels of sIL-2R decreased rapidly within 6 months, but these levels remained higher than those in normal controls, even after long-term EM therapy. en-copyright= kn-copyright= en-aut-name=FukudaTomoko en-aut-sei=Fukuda en-aut-mei=Tomoko kn-aut-name=福田智子 kn-aut-sei=福田 kn-aut-mei=智子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=diffuse panbronchiolitis kn-keyword=diffuse panbronchiolitis en-keyword=erythromycin kn-keyword=erythromycin en-keyword=呼吸機能 kn-keyword=呼吸機能 en-keyword=soluble IL-2 reseptor kn-keyword=soluble IL-2 reseptor en-keyword=喀痰中細菌叢 kn-keyword=喀痰中細菌叢 END start-ver=1.4 cd-journal=joma no-vol=109 cd-vols= no-issue=3-6 article-no= start-page=57 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study of the living environment and activities of daily living in centenarians kn-title=長寿者の居住地の特性と日常生活動作能力 (Activities of Daily Living : ADL) en-subtitle= kn-subtitle= en-abstract= kn-abstract=A study on relationship between the living environment and activities of daily living (ADL) was conducted to all eldery persons of more than 100 years old in 1993. The response was received from 840 males (73.6%) of 100-107 years of ages. Living environment was devided into three areas according to the geographical areas (Hokkaido-Tohoku-Hokuriku-Sanin, Kanto-Tokai-Kinki, and Sanyo-Shikoku-Kyushu), two community types according to an urban or an agricultural or fishing village, and four community sizes according to number of the population. Factors considered to contribute to a high level of ADL were evaluated. The results can be summarized as follows. 1. According to the geographical area, the independence rate (percentage of individuals who were competent for ADL) was significantly higher in Sanyo-Shikoku-Kyushu area than in Kanto-Tokai-Kinki area in all items examined (transferring, feeding, continence and bathing). Regional differences were observed in the state of living, state of medical care, social and cultural activities, and dietary habit since the age of 80 years, watching TV and an interest in health as social and cultural activites were related to high independence rates in areas such as Sanyo. 2. According to the community type, the state of medical care, whether there was a family doctor, social and cultural activities, and dietary habit since tha age of 80 years in agricultural and fishing communities appeared to be favorable for independence rate, but there were not observed significant relations. 3. According to the community size, none of the residents in large cities were independent in eating, continence, or bathing. The independence rate of continence was significantly lower than that in small cities and towns or villages in rural districts, suggesting that large cities are an environment unfavorable for socially independent longevity. The household composition, social and cultural activities, and dietary habit since the age of 80 years were different according to the community size, and reading newspapers of social and cultural activities was related to high independence rates in small cities and towns or villages of rural districts. en-copyright= kn-copyright= en-aut-name=ArakiHidetoshi en-aut-sei=Araki en-aut-mei=Hidetoshi kn-aut-name=荒木英俊 kn-aut-sei=荒木 kn-aut-mei=英俊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学講座 en-keyword=長寿者 kn-keyword=長寿者 en-keyword=日常生活動作能力 kn-keyword=日常生活動作能力 en-keyword=居住地の特性 kn-keyword=居住地の特性 END start-ver=1.4 cd-journal=joma no-vol=112 cd-vols= no-issue=9-12 article-no= start-page=199 end-page=203 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20001225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Breast quadrantectomy operative procedure in Okayama Cantral Hospital kn-title=当院における乳房扇状部分切除術術式 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Our breast quadrantectomy operative procedure and the clinical results are reported. We have peformed this method in 19 patients with stage T and U breast cancer under general anesthesis. A negative margin of cancer was confirmed by intraoperative histological exami-nation. Our method of quadrantectomy was performed without sturing both cut edges, which allowed intestitial fluid to collect. Of nineteen patients operated using this method, 17 were satisfied with the cosmetic results. Burn and infection were the causes of deformity of the preserved breast. Tight adaptation of the skin suture, avoiding burns due to elecrocauterry and suturing of the residual duct are recomended procedures for satisfactory results. en-copyright= kn-copyright= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=1 ORCID= en-aut-name=KojimaKazushi en-aut-sei=Kojima en-aut-mei=Kazushi kn-aut-name=小島一志 kn-aut-sei=小島 kn-aut-mei=一志 aut-affil-num=2 ORCID= en-aut-name=KenmotsuMasakazu en-aut-sei=Kenmotsu en-aut-mei=Masakazu kn-aut-name=剣持雅一 kn-aut-sei=剣持 kn-aut-mei=雅一 aut-affil-num=3 ORCID= en-aut-name=OkaItsuho en-aut-sei=Oka en-aut-mei=Itsuho kn-aut-name=岡伊津穂 kn-aut-sei=岡 kn-aut-mei=伊津穂 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山中央病院外科 affil-num=2 en-affil= kn-affil=岡山中央病院外科 affil-num=3 en-affil= kn-affil=岡山中央病院外科 affil-num=4 en-affil= kn-affil=岡山中央病院外科 en-keyword=乳癌 kn-keyword=乳癌 en-keyword=乳房扇状部分切除術 kn-keyword=乳房扇状部分切除術 en-keyword=乳房温存手術 kn-keyword=乳房温存手術 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=透析患者における中枢性無呼吸と閉塞性無呼吸の予見因子 kn-title=The predictors of central and obstructive sleep apnoea in haemodialysis patients en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TadaTakeshi en-aut-sei=Tada en-aut-mei=Takeshi kn-aut-name=多田毅 kn-aut-sei=多田 kn-aut-mei=毅 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue= article-no= start-page=11 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040701 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ウンシュウミカンにおける特殊肥料の施用効果の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=桑木信輔 kn-aut-sei=桑木 kn-aut-mei=信輔 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=大平猪一朗 kn-aut-sei=大平 kn-aut-mei=猪一朗 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高畑真澄 kn-aut-sei=高畑 kn-aut-mei=真澄 aut-affil-num=3 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name=村田芳行 kn-aut-sei=村田 kn-aut-mei=芳行 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=株式会社バイオバンク affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=89 end-page=97 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical significance of eosinophilic leucocytes in onset mechanisms of bronchial asthma kn-title=気管支喘息の発症病態における好酸球の臨床的意義 en-subtitle= kn-subtitle= en-abstract=Participation of eosinophil leucocytes in onset mechanisms of bronchial asthma was discussed in following sections ; 1. changes in number of eosinophils in the peripheral blood, 2. emergence of eosinophils in local allergic reaction sites, 3. eosinophils and allergic reactions, 4. different functions of eosinophils III allergic reactions, 5. eosinophils and clinical types of bronchial asthma. The results showed that eosinophilia in the peripheral blood was generally observed in patients with bronchial asthma. In these cases, eosinophils migrated into local allergic reaction sites. A reversed correlation was present between number of eosinophils and macrophages, and number of eosinophils correlated to a certain extent with number of lymphocytes in the small airways and alveolar region. Function of eosinophils was shown to be different between IgE-and non-IgE-mediated reactions, by measurement of arylsulfatase activity III BALF. Marked eosinophilia in BALF was observed in any clinical types of atopic asthma, although eosinophils were increased only in bronchoconstriction + hypersecretion type (type II) of non-atopic asthma. kn-abstract=末梢血好酸球が気管支喘息の発症病態にどのように関与しているかについて，1．末梢血好酸球の変動，2．好酸球の局所出現，3，好酸球とアレルギー反応，4．アレルギー反応と好酸球の機能，5．好酸球と喘息の臨床病態の各項目で検討した。その結果，気管支喘息では，全般的に末梢血好酸球増多がみられ，同時にアレルギー反応局所への遊走が観察されること，末梢気 道では，ある程度肺胞マクロファージの出現と逆相関にあること，リンパ球との関連もある程度認められることなどが示された。そして，局所出現した好酸球は，IgE抗体の関与の程度により，その機能が異なる可能性が示唆された。また臨床病型別の検討では，アトピー型ではいずれの臨床山型においても好酸球の出現率は明かな増加傾向を示したが，非アトピー型では，Ib．気管支攣縮＋過分二型においてのみ好酸球増多が著明であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=6 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=好酸球 (Eosinophils) kn-keyword=好酸球 (Eosinophils) en-keyword=肺生検 (Lung biopsy) kn-keyword=肺生検 (Lung biopsy) en-keyword=気管支肺胞洗浄 (Bronchoalveolar lavage) kn-keyword=気管支肺胞洗浄 (Bronchoalveolar lavage) en-keyword=臨床病型 (Clinical type) kn-keyword=臨床病型 (Clinical type) en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=129 end-page=133 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of atopic asthma characterized by marked neutrophilia in BALF kn-title=気管支肺胞洗浄液（BALF）中に高度の好中球増多の見られたアトピー型喘息の一例 en-subtitle= kn-subtitle= en-abstract=The clinical course and characteristics of a case with atopic asthma, showing marked neutrophilia in BALF and severe asthma attacks, were observed the frequency of neutrophils in BALF decreased followed by the improvement of her asthma attacks with therapy. The frequency of neutrophils in BALF was 65.4% at the initial stage before the therapy and decreased to 5.6% at attackfree stage after the therapy. The changes in frequency of neutrophils in BALF, obserbed in this case, should be noticed, because the cell in BALF were hardly affected by any treatment. kn-abstract=気管支肺胞洗浄液（BALF）中に高度の好中球の増多が見られ，治療により臨床症状の軽快と共にBALF中の好中球の減少を認めたアトピー型喘息の一例を経験した。経過中5回施行したBALF中の好中球百分率はそれぞれ65.4％，56.2％，42.4％，5.6％，5.6％であり，4回目，5回目では著明な好中球減少を認めた。本症例の如き症例は今後増加することが予想され，その発症病態を含め今後さらに症例を重ねて検討して行く必要があると 考えられた。 en-copyright= kn-copyright= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=4 ORCID= en-aut-name=TanizakiYoshirou en-aut-sei=Tanizaki en-aut-mei=Yoshirou kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=5 ORCID= en-aut-name=KataokaHisakazu en-aut-sei=Kataoka en-aut-mei=Hisakazu kn-aut-name=片岡久和 kn-aut-sei=片岡 kn-aut-mei=久和 aut-affil-num=6 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=7 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=8 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=アトピー型喘息 (Atopic asthma) kn-keyword=アトピー型喘息 (Atopic asthma) en-keyword=好中球 (Neutrophil) kn-keyword=好中球 (Neutrophil) en-keyword=気管支肺胞洗浄法 (Bronchoaiveolar lavage) kn-keyword=気管支肺胞洗浄法 (Bronchoaiveolar lavage) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=7 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Spa therapy for chronic respiratory diseases - in subjects admitted in 1989. - kn-title=慢性呼吸器疾患の温泉療法 en-subtitle= kn-subtitle= en-abstract=Backgrounds and immunological characteristics were studied in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1989. At the same time, clinical effects of spa therapy were evaluated for these patients. 1. Eighty five patients with chronic respratory diseases comprised 65 patients with bronchial asthma, 4 with pulmonary emphysema, 4 with lung tuberculosis, 3 with allergic granulomatous angitis, 3 with obstructive bronchiolitis, 2 with bronchiectasia, 2 with chronic bronchitis and 2 with hypersensitivity pneumonitis. 2. Sixty three patients (74.1%) out of the 85 cases had spa therapy. 3. Out of 51 patients coming from Tottori prefecture, 32 cases (62.7%) received spa therapy. On the other hand, spa therapy was carried out for 19 cases (95.0%) out of the 20 cases from Okayama prefecture, and for 12 cases (85.7%) out of the 14 cases from the other prefectures (long distant areas). 4. Many cases with bronchial asthma showed low serum levels of IgE (lower than 200 IU/ml), and frequency of positive skin reactions to various allergens was low in the patients with bronchial asthma. Serum cortisol levels were very low in patients with steroid-dependent asthma. 5. Spa therapy was effective in 41 cases (80.3%) out of the 51 patients with bronchial asthma. Spa therapy also effective for patients with obstructive bronchiolitis, and allergic granulomatous angitis. kn-abstract=1989年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者85例（延べ90例）を対象に，その背景因子，臨床的特徴，および温泉療法の臨床効果について検討を加えた。(1)対象85例のうちわけは，気管支喘息65例，肺気腫4例，肺結核症4例，アレルギー性肉芽腫性血管炎3例，閉塞性細気管支炎3例，気管支拡張症2例，慢性気管支炎2例，過敏性肺臓炎2例であり，昨年度と異なり肺結核がやや多かったことが特徴的であった。(2)これら85症例のうち，温泉療法を受けた症例は63例(74.1％)であった。(3)温泉療 法を受けた症例の地域分布では，鳥取県からの入院症例51例では32例(62.7％)であり，同様に岡山県からの入院症例20例では19例(95.0％)，その他の県からの入院症例14例で12例(85.7％)であった。4．温泉療法の臨床効果は，気管支喘息では51例中著効14例，有効27例，やや有効8例，無効2例であり，明らかな有効例は41例（80.3％)であった。 en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=6 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=7 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=閉塞性細気管支炎 (Obstructive bronchiolitis) kn-keyword=閉塞性細気管支炎 (Obstructive bronchiolitis) en-keyword=慢性気管支炎 (Chronic bronchitis) kn-keyword=慢性気管支炎 (Chronic bronchitis) en-keyword=血清コーチゾール値 (Serum cortisol level) kn-keyword=血清コーチゾール値 (Serum cortisol level) en-keyword=温泉療法 (Spa therapy) kn-keyword=温泉療法 (Spa therapy) END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=16 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199009 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者末梢血好塩基球の抗ヒトIgEおよびカルシウムイオノフォァA23187に対する反応性について kn-title=Basophil reactivity to anti-IgE and calcium ionophore A23187 in patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=気管支喘息27例および健康人7名を対象に，抗ヒトIgEおよびカルシウムイオノフォァA23187（CaI)刺激時の末梢血好塩基球からのヒスタミン遊離について検討を加えた。(1)抗ヒトIgEおよびCaI刺激時の好塩基球からのヒスタミン遊離は，非アトピー型喘息に比べ，アトピー型喘息において有意に高い値を示した。(2)これらの刺激物質によるヒスタミン遊離は，非使用例に比べ，ステロイド依存性喘息において低い傾向がみられた。また，年齢では39才以下，発症年齢では39才以下でヒズタミン遊離がより高い傾向がみられた。(3)血清IgE値の高い症例の好塩基球は，低い症例に比べより多くのヒスタミンを遊離する傾向がみられた。(4)全般的には，抗ヒトIgE刺激によるヒスタミン遊離とCaI刺激時の遊離との間にはある程度の相関がみられた。以上の結果より，好塩基球の反応性はいろいろの条件下でかなり異なることが示唆された。 kn-abstract=The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=SudoMichiyasu en-aut-sei=Sudo en-aut-mei=Michiyasu kn-aut-name=周藤眞康 kn-aut-sei=周藤 kn-aut-mei=眞康 aut-affil-num=2 ORCID= en-aut-name=KitaniHikaru en-aut-sei=Kitani en-aut-mei=Hikaru kn-aut-name=貴谷光 kn-aut-sei=貴谷 kn-aut-mei=光 aut-affil-num=3 ORCID= en-aut-name=KawauchiKazuhisa en-aut-sei=Kawauchi en-aut-mei=Kazuhisa kn-aut-name=河内和久 kn-aut-sei=河内 kn-aut-mei=和久 aut-affil-num=4 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=5 ORCID= en-aut-name=OkudaHiroyuki en-aut-sei=Okuda en-aut-mei=Hiroyuki kn-aut-name=奥田博之 kn-aut-sei=奥田 kn-aut-mei=博之 aut-affil-num=6 ORCID= en-aut-name=KomagoeHaruki en-aut-sei=Komagoe en-aut-mei=Haruki kn-aut-name=駒越春樹 kn-aut-sei=駒越 kn-aut-mei=春樹 aut-affil-num=7 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋清 kn-aut-sei=高橋 kn-aut-mei=清 aut-affil-num=9 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院産科婦人科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院第二内科 affil-num=10 en-affil= kn-affil=岡山大学医学部附属病院第二内科 en-keyword=Histamine release (ヒスタミン遊離) kn-keyword=Histamine release (ヒスタミン遊離) en-keyword=Basophils (好塩基球) kn-keyword=Basophils (好塩基球) en-keyword=Anti-lgE (抗ヒトIgE) kn-keyword=Anti-lgE (抗ヒトIgE) en-keyword=Calcium ionophore A 23187 (カルシウムイオノフォァA23187) kn-keyword=Calcium ionophore A 23187 (カルシウムイオノフォァA23187) en-keyword=Bronchial asthma (気管支喘息) kn-keyword=Bronchial asthma (気管支喘息) END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=1 article-no= start-page=85 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Photodecomposition of Ergosterol by Near-UV irradiation in the Plasma Membrane of the Yeast Rhodotorula minuta kn-title=長波長紫外光照射による酵母 Rhodotorula minuta 細胞膜エルゴステロールの分解 en-subtitle= kn-subtitle= en-abstract=酵母Rhodotorula minutaにおけるカロテノイドの光誘導合成および細胞膜の機能損傷に関わる初期光化学反応についての知見を得る目的で、長波長紫外光(UV-A光)による細胞膜エルゴステロールの分解を調べ、次の結果を得た。酵母菌体および菌体から調製した細胞膜調製品に長波長紫外光を照射すると吸収スペクトルに微細な変化が生じることを認めた。細胞膜調製品に生じた吸収スペクトルの変化は細胞膜エルゴステロールが光化学分解を受けることを予想させ、この予想はHPLC分析によって確かめられた。また、モデル系での実験によって、細胞膜中のエルゴステロールの光化学反応には特別な光受容体あるいは光増感剤は介在しておらず、エルゴステロール自身が光受容体であり反応基質となっていることが明らかになった。 kn-abstract=In search for primary photochemical reaction related to photoinduced carotenogenesis and photoinactivivation in yeast Rhodotorula minuta, the influence of near-UV radiation (300-400 nm) on ergosterol in the plasma membrane of the yeast. Irradiation by near-UV of intact cells and the plasma membrane preparation from the yeast caused changes in their absorption spectra. For the plasma membrane, difference spectra measured after irradiation of near-UV suggested the decomposition of ergosterol and the suggestion was proved by HPLC analysis. Experiments in model systems revealed that ergosterol itself was the photoreceptor in the photochemical reaction, and that there was not any other photoreceptor or photosensitizer which was related to photochemical reaction of ergosterol decomposition in the plasma membrane. en-copyright= kn-copyright= en-aut-name=NakaumaMakoto en-aut-sei=Nakauma en-aut-mei=Makoto kn-aut-name=中馬誠 kn-aut-sei=中馬 kn-aut-mei=誠 aut-affil-num=1 ORCID= en-aut-name=AramiShin-ichiro en-aut-sei=Arami en-aut-mei=Shin-ichiro kn-aut-name=荒見真一郎 kn-aut-sei=荒見 kn-aut-mei=真一郎 aut-affil-num=2 ORCID= en-aut-name=HadaMegumi en-aut-sei=Hada en-aut-mei=Megumi kn-aut-name=秦恵 kn-aut-sei=秦 kn-aut-mei=恵 aut-affil-num=3 ORCID= en-aut-name=NakagawaIchiro en-aut-sei=Nakagawa en-aut-mei=Ichiro kn-aut-name=中川一郎 kn-aut-sei=中川 kn-aut-mei=一郎 aut-affil-num=4 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name=村田芳行 kn-aut-sei=村田 kn-aut-mei=芳行 aut-affil-num=5 ORCID= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=農林水産省食品総合研究所 affil-num=3 en-affil= kn-affil=神戸大学理学部 affil-num=4 en-affil= kn-affil=九州農政局 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 en-keyword=Rhodotorula minuta kn-keyword=Rhodotorula minuta en-keyword=near-UV kn-keyword=near-UV en-keyword=ergosterol kn-keyword=ergosterol en-keyword=absorbance change kn-keyword=absorbance change END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=1 article-no= start-page=59 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=199802 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Neuronal　Cell Death in Cultured PC12 Cells kn-title=培養ＰＣ １２細胞を用いた神経細胞死誘導法の検討 en-subtitle= kn-subtitle= en-abstract=[目的]神経細胞死の様式には自滅的な細胞死であるアポトーシスと、偶発的外因による受動的な細胞死であるネクローシスの二つがある。現在、この神経細胞死の機構解明のために、各種の培養神経細胞が研究に利用されているが、とりわけ、ラット副腎髄質由来親クロム性細胞腫PC12細胞は、神経細胞のモデル細胞として多くの研究者に用いられている。本研究では、このPC12細胞に各種神経細胞死誘発剤を添加し、簡便で精度の高い細胞死測定法の確立を検討した。[方法及び結果]細胞死誘発には抗癌剤、各種の情報伝達阻害剤及びセラミド誘導体などを使用した。細胞死の判定は、細胞死に伴う細胞膜破壊により培養培地中に遊離される乳酸脱水素酵素(LDH)の活性測定により行った。抗癌剤であるEtoposide及びCamptothecinを1-50γMの濃度で処理したところ、両者とも細胞死誘導がみられた。また、プロテインキナーゼC阻害剤であるK252a、Calphostin C及びStaurosporineを24時間処理すると、1γMで有意の細胞死が認められた。さらに、各種セラミド誘導体、過酸化水素並びにβーアミロイドペプチドを24時間処理したところ、同様に細胞死誘導が認められた。形態学的観察により過酸化水素誘導細胞死はネクローシスであり、それ以外の細胞死はアポトーシスであることが判明した。本研究により、PC12細胞を用いた各種細胞死誘導剤によりin vitroでの簡便な神経細胞死の評価系が確立された。 kn-abstract=Rat pheochromocytoma (PC12cells) were recently shown to be a useful model for studying the mechanism of cell death and its prevention by different agents. We show here that the diverse reagents of anticancer drugs, protein kinase C inhibitors, H2o2, and βーamyloid peptides also induce cell death in PC12 cells. Cell death was detected by released activity of lactate dehydrogenase (LDH) from intracellular to medium. These results prompted us to investigate whether cell death in PC12 cells might be induced by different pathways. en-copyright= kn-copyright= en-aut-name=TakahataKyoya en-aut-sei=Takahata en-aut-mei=Kyoya kn-aut-name=高畑京也 kn-aut-sei=高畑 kn-aut-mei=京也 aut-affil-num=1 ORCID= en-aut-name=Inouchisaori en-aut-sei=Inouchi en-aut-mei=saori kn-aut-name=井内砂織 kn-aut-sei=井内 kn-aut-mei=砂織 aut-affil-num=2 ORCID= en-aut-name=MonobeKeiichi en-aut-sei=Monobe en-aut-mei=Keiichi kn-aut-name=物部啓一 kn-aut-sei=物部 kn-aut-mei=啓一 aut-affil-num=3 ORCID= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=PC12 cells kn-keyword=PC12 cells en-keyword=neuronal cell death kn-keyword=neuronal cell death en-keyword=apoptosis kn-keyword=apoptosis en-keyword=necrosis kn-keyword=necrosis en-keyword=LDH kn-keyword=LDH END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=1 article-no= start-page=45 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=200002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Photochemical Products from Ergosterol in the Plasma Membrane of the Yeast Rhodotorula minuta cells illuminated by Near-UV kn-title=長波長紫外光によって酵母 Rhodotorula minuta 細胞膜に生じるエルゴステロールの光化学反応生成物 en-subtitle= kn-subtitle= en-abstract=赤色酵母R.minuta細胞膜に長波長紫外光を照射した時に生じるエルゴステロール由来の光化学反応生成物の単離・精製およびその同定を行った。結果、3種類の物質が単離・精製され、そのうち1つはPrevitamin D2であることが同定され、残りの2つについてはergosta-4,7,22-trien-3-on の何かの炭素にOH基が付いたものであることが分かった。単離した成分を培地に加え、菌体の増殖とカロテノイド生合成に対する影響を調べた結果、これらの物質はそのどちらにも影響を及ぼさなかった。 kn-abstract=When the plasma mumbrane of the yeast Rhodotorula minuta cells was exposed to near-UV at 0℃, three new compounds were formes photochemically with decrease in ergosterol content. When 0.4%-SDS solution containing ergosterol was illuminated with near-UV, the same three compounds as in the membrane were formed. As a result of instruments analysis, one of three photochemical products was identified as previtamine D2 and another two compounds were characterized chemically that they had the structure of ergosta-4, 7, 22-trein-3-on. In addition, these photochemical products did not affect the growth and carotenogenesis of the yeast Rhodotorulaminuta. en-copyright= kn-copyright= en-aut-name=NakaumaMakoto en-aut-sei=Nakauma en-aut-mei=Makoto kn-aut-name=中馬誠 kn-aut-sei=中馬 kn-aut-mei=誠 aut-affil-num=1 ORCID= en-aut-name=IriyamaTakuya en-aut-sei=Iriyama en-aut-mei=Takuya kn-aut-name=入山卓也 kn-aut-sei=入山 kn-aut-mei=卓也 aut-affil-num=2 ORCID= en-aut-name=MurataYoshiyuki en-aut-sei=Murata en-aut-mei=Yoshiyuki kn-aut-name=村田芳行 kn-aut-sei=村田 kn-aut-mei=芳行 aut-affil-num=3 ORCID= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=Rhodotorula minuta kn-keyword=Rhodotorula minuta en-keyword=near-UV kn-keyword=near-UV en-keyword=ergosterol kn-keyword=ergosterol en-keyword=photochemical products kn-keyword=photochemical products END start-ver=1.4 cd-journal=joma no-vol=95 cd-vols= no-issue=1 article-no= start-page=83 end-page=86 dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=200602 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Food Irradiation is Excellent Technology for Sanitation of Food kn-title=食品照射は食品の衛生化に優れた技術です en-subtitle= kn-subtitle= en-abstract= kn-abstract=　“Food Irradiation”is a technology to treat foods with ionizing radiation in order to secure a “supply of food” and to ensure the “safety of food”, which are critical issues facing the woeld. At present, according to IAEA information, 53 countries permit the use of food irradiation by low, and about 230 items which are commercially available in 30 countries are legally authorized. Japan has a 50 year history of research of food irradiation. In 1972, irradiation of potato for preventing germination was permitted by low, and commercial production began in 1974. Howrver, after 1974, the number of researchers drastically decreased and no practical irradiation process has been invented. Japan is now far behind other countries and is called an “underdeveloped country for food irradiation”. In order to break out of the current backward situation, researchers related to food irradiation in Japan face the neecessity for an enlightening movement. en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=food irradiation kn-keyword=food irradiation en-keyword=ionizing radiation kn-keyword=ionizing radiation en-keyword=sanitation of food kn-keyword=sanitation of food en-keyword=wholesomeness of food kn-keyword=wholesomeness of food en-keyword=safety of food kn-keyword=safety of food END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ヒト耳下腺唾液のリン酸カルシウム結晶成長抑制タンパクに関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田徹 kn-aut-sei=多田 kn-aut-mei=徹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=19940325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=コガネムシ類の飛翔筋多型発現機構と移動分散 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田茂男 kn-aut-sei=多田 kn-aut-mei=茂男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19870630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=揮発性吸入麻酔薬 enflurane,isoflurane の血中溶解機序に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田惠一 kn-aut-sei=多田 kn-aut-mei=惠一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=19740331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=胎仔及び新生仔赤血球造血に於けるサイクリックヌクレオチドの役目 kn-title=The role of cyclic nucleotide on fetal and neonatal erythropoiesis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田廣祠 kn-aut-sei=多田 kn-aut-mei=廣祠 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19901231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Subrenal capsule assay法による制癌剤感受性試験に関する研究 第1編 Subrenal capsule assay 法の基礎的検討 第2編 肺癌臨床材料を用いた Subrenal capsule assay 法の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TadaAtsuhiko en-aut-sei=Tada en-aut-mei=Atsuhiko kn-aut-name=多田敦彦 kn-aut-sei=多田 kn-aut-mei=敦彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19800331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=血液細胞膜構築の研究 第1編 Freeze-etching法による赤血球膜構築の検討 第2編 Freeze-etching法によるリンパ球膜構築の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=実験的家兎黄色腫における泡沫細胞の形成過程 その微細構造 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田譲治 kn-aut-sei=多田 kn-aut-mei=譲治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19911231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=L-ドーパ, ドパミンのヒト脱落膜プロスタグランデｨン産生に及ぼす効果 kn-title=Effects of L-Dopa or Dopamine on Human Decidual Prostaglandin Synthesis en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田克彦 kn-aut-sei=多田 kn-aut-mei=克彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=腱の再生,癒着に関する研究(第7報) 腱の再生に対するVinculaの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田寛也 kn-aut-sei=多田 kn-aut-mei=寛也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=1998 dt-pub=19981231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Brachytherapy 後の放射線障害に対するデキサメサゾンの保護効果 サル正常脳における検討 kn-title=The Protective Effect of Dexamethasone against Radiation Damage Induced by Interstitial Irradiation in Normal Monkey Brain en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田英二 kn-aut-sei=多田 kn-aut-mei=英二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=1 article-no= start-page=9 end-page=15 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes in Carotenoid Pattern during Development of Gardenia Fruit kn-title=クチナシ果実の発育に伴うカロチノイドパターンの変化 en-subtitle= kn-subtitle= en-abstract= kn-abstract=クチナシ果実中の主要色素であるクロシン(crocin:Digentiobiosyl 8,8’-diapocarotene-8,8'-dioate)の生合成についての知見を得ることを目的として,クチナシ果実の結実から完熟に至るまでの各発育段階におけるカロテノイド色素の含有量とその組成の変化を調べ,次の結果を得た. (1)肥大成長過程のクチナシ果実には殆どカロテノイド色素が認められず,成熟過程の開始後から生合成が始まり,完熟期にかけて急激な蓄積が起こった.そして,完熟期の乾燥果実は450mg%のカロテノイド色素を有していた. (2)成熟過程の何れの段階の果実にもβ-カロテンなどのC40-カロテノイドは少量しか含まれておらず,カロテノイド色素の大部分がクロシンを代表とするクロセチン(crocetin:8,8'-Diapocarotene-8,8'-dloic acid)の誘導体であった.そして,これらのクロセチン誘導体は何れも糖エステルであると推察された. (3)クチナシ果実の発育に伴うカロテノイド組成の変化を調べた結果から,クロセチン誘導体の幾つかは,クロシン生合成の中間前駆体であることが予想された。 en-copyright= kn-copyright= en-aut-name=IchiTakahito en-aut-sei=Ichi en-aut-mei=Takahito kn-aut-name=市隆人 kn-aut-sei=市 kn-aut-mei=隆人 aut-affil-num=1 ORCID= en-aut-name=KatayamaTsuyoshi en-aut-sei=Katayama en-aut-mei=Tsuyoshi kn-aut-name=片山豪 kn-aut-sei=片山 kn-aut-mei=豪 aut-affil-num=2 ORCID= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=クチナシ果実 kn-keyword=クチナシ果実 en-keyword=カロチノイドパターン kn-keyword=カロチノイドパターン en-keyword=クロシン kn-keyword=クロシン END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=1 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Damage of Membrane Functions in the Yeast Saccharomyces cerevisiae by Near-UV Irradiation kn-title=長波長紫外光による酵母Saccharomyces cerevisiae 細胞膜機能の損傷 en-subtitle= kn-subtitle= en-abstract= kn-abstract=酵母Saccharomyces cerevisiaeに長波長紫外光を照射すると,酵母の生存率は光量に依存して急激に低下した.この現象の発現機構についての知見を得るために,細胞膜機能として非常に重要な透過障壁能と能動輸送能の長波長紫外照射による損傷について,光量一効果曲線を作成して調べた. 酵母に10J/mlの長波長紫外光を照射すると生存率は50%に低下する.この照射光量は,細胞膜の透過障壁能の破壊を引き起こし,細胞内のカリウムイオンおよびナトリウムイオンの非選択的漏出と細胞膜非透過性物質の細胞内への浸入をもたらした .5J/ml以下の光量は酵母の生存率にほとんど影響を与えないが,アミノ酸の取り込み速度の著しい低下とポンプあるいはチャンネル機構の損傷を予想させるカリウムイオンの選択的漏出をもたらした.また,動力学的解析結果から,アミノ酸の取り込み速度低下の要因は､細胞膜表面に存在するレセプターの損傷によるものではなく､受容以降の輸送系の損傷によることが示唆された。 en-copyright= kn-copyright= en-aut-name=AramiShin-ichiro en-aut-sei=Arami en-aut-mei=Shin-ichiro kn-aut-name=荒見真一郎 kn-aut-sei=荒見 kn-aut-mei=真一郎 aut-affil-num=1 ORCID= en-aut-name=HadaMegumi en-aut-sei=Hada en-aut-mei=Megumi kn-aut-name=秦恵 kn-aut-sei=秦 kn-aut-mei=恵 aut-affil-num=2 ORCID= en-aut-name=ItadaniAsako en-aut-sei=Itadani en-aut-mei=Asako kn-aut-name=板谷安佐子 kn-aut-sei=板谷 kn-aut-mei=安佐子 aut-affil-num=3 ORCID= en-aut-name=YamashitaSatoko en-aut-sei=Yamashita en-aut-mei=Satoko kn-aut-name=山下智子 kn-aut-sei=山下 kn-aut-mei=智子 aut-affil-num=4 ORCID= en-aut-name=HachiyaKinji en-aut-sei=Hachiya en-aut-mei=Kinji kn-aut-name=蜂谷欽司 kn-aut-sei=蜂谷 kn-aut-mei=欽司 aut-affil-num=5 ORCID= en-aut-name=KaneyamaMunetoshi en-aut-sei=Kaneyama en-aut-mei=Munetoshi kn-aut-name=鑛山宗利 kn-aut-sei=鑛山 kn-aut-mei=宗利 aut-affil-num=6 ORCID= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 affil-num=7 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=1 article-no= start-page=61 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Induction of Cultured Cells from Tuberous Root of Sweet Potato(Ipomoea batatas L. cv. Benihayato)and Selection of a Stable and High Carotenoid-producing Strain kn-title=サツマイモ“紅隼人”(Ipomoea batatas L. cv. Benihayato)からの培養細胞の誘導と高カロテノイド色素生産細胞の選抜 en-subtitle= kn-subtitle= en-abstract= kn-abstract=サツマイモ(栽培品種名:紅隼人)の塊根組織を,1μM2,4-Dichloro-phenoxyacetic acid(2,4-D),3.0%sucroseと0.2%GELRITEを加えたLinsmaier-Skoog(LS)の固体培地に置床し,光照明(12時間の明暗サイクル)の下で培養することにより,少量のカロテノイド色素(35μg/g-乾物)を生成する培養細胞を誘導することができた.この誘導された培養細胞から,小集塊選抜法を繰り返すことによって高カロテノイド色素生産株の選抜を行った.22回の選抜と継代培養によって得られた培養細胞は,もとの誘導培養細胞の8倍に相当する265μg/g-物のカロテイド色素を生産し,その増殖率(収穫された新鮮物重量と接種した新鮮重量の比)は選抜を行う前の培養時に比して約3.5倍に増加した.選抜によって得た高カロテノイド色素生産株を液体懸濁培養に供し,より高いカロテノイド色素の生産条件の検討を行った.その結果,1μM2,4-Dと3.0%Sucroseを添加したLS液体培地を用い,3,000lxの照明下で振盪するのが最適であり,この条件で得られる培養細胞のカロテノイド色素含有量は,材料に用いた植物組織の含有量(200〜300μg/g-物)よりも高い385μg/g-物であった。 en-copyright= kn-copyright= en-aut-name=IchiTakahito en-aut-sei=Ichi en-aut-mei=Takahito kn-aut-name=市隆人 kn-aut-sei=市 kn-aut-mei=隆人 aut-affil-num=1 ORCID= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 en-keyword=サツマイモ kn-keyword=サツマイモ en-keyword=培養細胞 kn-keyword=培養細胞 en-keyword=高カロテノイド色素生産細胞 kn-keyword=高カロテノイド色素生産細胞 en-keyword=紅隼人 kn-keyword=紅隼人 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=1 article-no= start-page=33 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=1987 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Conversion of Epoxy-carotenoids and Color Changes of Citrus Unshiu Juice kn-title=温州ミカン果汁における色調の変化とエポキシカロチノイドの変換 en-subtitle= kn-subtitle= en-abstract= kn-abstract=温州ミカン果汁の色調の変化は,果汁中に存在するクエン酸などの有機酸の触媒作用によって,5,6-エポキシカロチノイドが5,8-フラノキシカロチノイドヘ変換することに起因することを認めた. この変換は果汁製造工程および流通過程を通じてゆっくり進行し,約5週間で完結することを明らかにした. また,この変換がシリカゲルによっても触媒されること,5,8-フラノキシカロチノイドはシリカゲルに吸着されると緑色を呈することも認めた。 en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=1 article-no= start-page=27 end-page=32 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=1987 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Xanthophyll Ester of Citrus Unshiu Juice kn-title=温州ミカン果汁中のキサントフィルエステル en-subtitle= kn-subtitle= en-abstract= kn-abstract=温州ミカン果肉のキサントフィルの大部分は非常に極性の低いエステルとして存在している. TLC,GLCによる分析の結果,それらはラウリン酸,ミリスチン酸,パルミチン酸などの高級脂肪酸エステルであった. 温州ミカンの代表的な7系統の果肉を分析した結果,エステル含有量(78-84%)もエステル化率(85-90%)も共に高い値を示すとともに,系統間に殆ど差がなく,これらの値は温州ミカンに普遍的な値と考えられる. また,これらの値は,製造工程及び流通過程において殆ど変化せず,果汁の純度判定の指標となりうるものと考えた。 en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=1 article-no= start-page=17 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=1987 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Identification of Carotenoids in Citrus Unshiu Juice kn-title=温州ミカン果汁中のカロチノイドの単離同定 en-subtitle= kn-subtitle= en-abstract= kn-abstract=温州ミカン果汁のカロチノイドをカラムクロマトグラフィーと薄層クロマトグラフィーで分離して26種のカロチノイドを同定したが,2フラクションについては未同定に終った. 最も多かったカロチノイドはモノハイドロオキシカロチンのβ-ｃryptoxanthinで全カロチノイドの44.3%,有色カロチノイドの半分以上を占めている. その他のカロチノイドで多いものは,無色カロチノイドのphytoene(8.8%),phytofuene(8.0%),炭化水素カロチンのβ-carotene(4.2%),5-carotene(5.2%),モノハイドロオキシカロチンのa-cryptoxanthin(7.9%),ジハイドロオキシモノエポキシカロチンのmutatoxanthin(3.7%),ジハイドロキシジエポキシカロチンのauroxanthin(6.2%)などである. 上記のように,主要カロチノイドの大部分はβ-ｃaroteneの誘導体であった。 en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=1 article-no= start-page=59 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=1985 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Mechanism of Photoregulated Carotenogenesis in Rhodotorula minuta : VI. Changes of Photosensitivity and Induce Capability of Cell to Synthesize Carotenoid kn-title=Rhodotorula minutaにおけるカロチノイド生合成の光制御機構VI 光感応能と誘導能の変化について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rhodotorula minutaにおけるカロチノイド生合成の光制御に含まれる光化学反応に関係する物質についての知見を得るために光感応能と誘導能の変化を調べた. 光感応能は光が照射されない限り非常に安定であった. 菌体に光が照射されると光感応能は減少したが,その菌体を生育条件下で培養すると,光感応能は5時聞以内にもとのレベルにまで回復した. 光照射によって獲得したカロチノイド合成の誘導能は,生物化学反応が進行する条件下ではすばやく減少し,5時聞以内に消滅した. しかしながら,生物化学反応が進行しない条件下では極めて安定であった. 光感応能の回復と誘導能の減少は,シクロヘキシミドで阻害された. これらの結果に基づいて,光化学反応に必要な物質−光受容体と反応基質−は菌体中では非常に安定で代謝的分解を受けない事,カロチノイド生合成の誘導因子として作用する光化学反応生成物はタンパク合成の進行と共役してもとの反応基質に戻る事を推察した. 菌体に蓄積されたカロチノイドが光感応能に影響を与えなかったという事実は,光受容体によって吸収される光波長はカロチノイドによって吸収される光波長よりも短いかあるいは長い事を示唆した。 en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= en-aut-name=TadaYoshimaru en-aut-sei=Tada en-aut-mei=Yoshimaru kn-aut-name=多田善丸 kn-aut-sei=多田 kn-aut-mei=善丸 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=1 article-no= start-page=35 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=1981 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effect of Phosphate on the Growth and Toxin-Producing Ability of a Bacterium Isolated from Nematode Bursaphelenchus lignicolus kn-title=マツノザイセンチュウから単離したバクテリアの生育と毒素生産に及ぼすリン酸塩の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=病原性を有するマツノザイセンチュウから単離したバクテリアの完全合成培地を確立し,生育と毒素生産について検討した. 1)バクテリアの生育には,高濃度の無機リン酸塩が必要であり,最適濃度は100mMであった. この無機リン酸塩はATPでは代用できなかったが,G-1-Pは充分な増殖をもたらした. 2)バクテリアの毒素生産能は,普通ブイヨン培地で培養すると消滅するが,高濃度のリン酸塩を含有する培地で培養すると誘導される. 3)毒素生産にはマツの水抽出液が必須であり,毒素の前駆体はマツの体内に存在すると考えられた. 以上の学験結果から,バクテリアは,マツノザイセンュチウの体内でその代謝中間体である,ある種のリン酸化合物を栄養源として増殖し,さらに毒素生産能を獲得した後,マツの材中に放出され,特定の成分を毒素に変換することが推察される。 en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= en-aut-name=OmizuAkimasa en-aut-sei=Omizu en-aut-mei=Akimasa kn-aut-name=大水章正 kn-aut-sei=大水 kn-aut-mei=章正 aut-affil-num=2 ORCID= en-aut-name=ShiroishiMasahide en-aut-sei=Shiroishi en-aut-mei=Masahide kn-aut-name=白石正英 kn-aut-sei=白石 kn-aut-mei=正英 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=3 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=水稲の生育に及ぼす緩効性窒素肥料の肥効比較試験（第2報） en-subtitle= kn-subtitle= en-abstract= kn-abstract=湛水により強還元化する特性の水田土壌において,機械移植及び乾田直播の2方式により水稲栽培を行い,LP複合444肥料の肥効について検討した。1)直播栽培の場合の施肥量を,移植栽培のそれよりも多くした場合でも,水稲収量は移植栽培が直播栽培よりもやや高い値を示した。2)LP複合444のようなlong typeの肥料は強還元的性質の土壌には効果的であり,それは従来言われてきたような乾田直播栽培のみならず移植栽培の水稲の生育にも同様な効果が期待できた。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=1 end-page=2 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=19930315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=水田における生わら連用の効果（第2報） en-subtitle= kn-subtitle= en-abstract= kn-abstract=造成以来約30年間,生わらの全量施用と全量撤去を継続中の干拓地水田で,乾田直播と移植の栽培様式の違いが水稲収量に及ぼす影響について検討した。1)直播栽培では,生わらの連続施用は連続撤去に比べ高い収量をもたらした。一方,移植栽培では,生わらの連続施用は連続撤去よりも低い収量であった。この傾向は異常気象年においても認められた。2)移植栽培では,生わらの連続施用は連続撤去に比べ,初期生育から後期生育まで生育量が低い傾向を示した。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=6 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=19900320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=水稲の生育に及ぼす緩効性窒素肥料の肥効比較試験 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三宅靖人 kn-aut-sei=三宅 kn-aut-mei=靖人 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue= article-no= start-page=7 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19871228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=水田における生わら連用の効果 干拓新田の場合 en-subtitle= kn-subtitle= en-abstract= kn-abstract=干拓新田土壌(八浜土壌)の水稲の生育に対する生わら連用の効果について検討した。1)直播栽培水稲においては生わら施用がわずかに増収をもたらした。しかし移植栽培水稲においては生わら施用は減収となった。それは生わら施用が土壌の強還元化を促進したためと考えられる。2)成熟土壌の岡山土壌に比べ,未熟土壌の干拓新田土壌(八浜土壌)は,湛水に伴う土壌の還元化が強度に進行する特徴が推定された。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=花房徳治 kn-aut-sei=花房 kn-aut-mei=徳治 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue= article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=1987 dt-pub=19871228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=直播栽培水稲の生育に対するケイ酸とカルシウムの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=水稲の生育に対するケイ酸とカルシウムの相互関係について検討した。対照区(Si, Ca無添加)に対して,ケイ酸単用区,ケイ酸+カルシウム区およびカルシウム単用区で顕著に高い収量が認められた。それはケイ酸単用区ではケイ酸添加の効果が,カルシウム単用区においては一時的に土壌反応変換効果により土壌窒素の供給が高まったためと推定される。またケイ酸+カルシウム区における増収の原因は前述のケイ酸の効果と一時的な土壌反応変換効果による土壌窒素の供給増によってもたらされたことによると考えられる。そしてこの増収は穂数および一穂粒数の増加によってもたらされた。茎葉中のSiO2%はケイ酸添加区で対照区,カルシウム単用区に比べ明らかに高い値を示した。そしてカルシウム添加は茎葉中のSiO2%をわずかに低下さす傾向が認められた。茎葉中のCa%はカルシウム添加により,きわめてわずかに増加の傾向が認められた。跡地土壌のpHは大量のアルカリ資材の混入にもかかわらず7.0以下であり,生育への悪い影響は考えられなかった。また跡地土壌中の可給態ケイ酸量はケイ酸質肥料の施肥により,顕著に高い値を示した。一方,跡地土壌中の置換性カルシウム量はカルシウム添加区のみならずケイ酸単用区においても対照区より高い値を示した。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三宅靖人 kn-aut-sei=三宅 kn-aut-mei=靖人 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=花房徳治 kn-aut-sei=花房 kn-aut-mei=徳治 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=20 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=岡山地方におけるバレイショ多収栽培に関する基礎的研究 (第4報)高収量年における収量形質の特徴 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurodaToshiro en-aut-sei=Kuroda en-aut-mei=Toshiro kn-aut-name=黒田俊郎 kn-aut-sei=黒田 kn-aut-mei=俊郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=工藤久美寿 kn-aut-sei=工藤 kn-aut-mei=久美寿 aut-affil-num=2 ORCID= en-aut-name=TadaMasato en-aut-sei=Tada en-aut-mei=Masato kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=4 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=乾田直播栽培水稲の生育に及ぼすケイ酸質肥料の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三宅靖人 kn-aut-sei=三宅 kn-aut-mei=靖人 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=花房徳治 kn-aut-sei=花房 kn-aut-mei=徳治 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue= article-no= start-page=24 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19850627 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=岡山地方におけるバレイショ多収栽培に関する基礎的研究 (第3報)低収量年における収量形質の特徴 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurodaToshiro en-aut-sei=Kuroda en-aut-mei=Toshiro kn-aut-name=黒田俊郎 kn-aut-sei=黒田 kn-aut-mei=俊郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宗友義美 kn-aut-sei=宗友 kn-aut-mei=義美 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue= article-no= start-page=31 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=1984 dt-pub=19840702 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=岡山地方におけるバレイショ多収栽培に関する基礎的研究 第2報 収量形質に及ぼす品種・栽植密度・施肥量の相互作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KurodaToshiro en-aut-sei=Kuroda en-aut-mei=Toshiro kn-aut-name=黒田俊郎 kn-aut-sei=黒田 kn-aut-mei=俊郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=宗友義美 kn-aut-sei=宗友 kn-aut-mei=義美 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=1 article-no= start-page=63 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=1978 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Influence of the Light Illumination on the Growth and the Carotenoid Formation of Rhodotorula minuta kn-title=Rhodotorula minutaの生育およびカロチノイド生成におよぼす光の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rh.minutaの生育とカロチノイド生成への光照射の影響を調べる目的で,照射光の光強度および光質を異にする条件下で菌体を培養して,増殖,炭素源及び窒素源の消費,酸素吸収量ならびにカロチノイド含有量を調べた. その結果は次のようである. 1)菌体の増殖は5000lux以下の光強度ではほとんど影響を受けないが,8000luxの照射によって幾分阻害が認められた. 2)Rh.minutaのカロチノイド生成は光照射によって著しく影響されるにもかかわらず,グルコース,L-バリンの消費には殆ど変化が認められなかった. 3)菌体のカロチノイド含有量は照射された光の全エネルギーとは関係なく,照射光強度にのみ支配されているように考えられた. 4)Rh.minutaのカロチノイド生成は400nm〜500nmの波長帯を有する光でのみ著しく促進された. この結果から,菌体内に存在するある種の黄色色素が光生物学的感応に関与する光受容体としての機能を有しているものと推論される。 en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= en-aut-name=ShiroishiMasahide en-aut-sei=Shiroishi en-aut-mei=Masahide kn-aut-name=白石正英 kn-aut-sei=白石 kn-aut-mei=正英 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=1 article-no= start-page=87 end-page=94 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=1977 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Culture Conditions on the Growth and Carotenoid Formation in Rhobotorula minuta kn-title=Rhodotorula minutaの生育およびカロチノイド生成に及ぼす培養条件の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rhodotorula minutaの生育およびカロチノイド生成に及ぼす糖類,アミノ酸類ならびにピタミン類の影響について調べた. また光の影響についても併せて検討した. 1)炭素源としはグルコース,マンノース,シュークローズが良く,フラクトース,マルトース,ラクトースは利用されない. 2)L-ロイシン,L-イソロイシン,L-システイン,L-メチオニン以外の大部分のアミノ酸は菌体生育の良い窒素源となる. L-ヒスチヂン,L-スレオニンを窒素源とした場合,菌体のカロチノイド生成量は抑制された. 3)チアミンはRh. minutaの生育に必須である. ビタミンのうちチアミンのみを加えた培養液にｐ-アミノ安息香酸を加えると,菌体収量及びカロチノイド生成量ともに著しく増大した. 4)黒暗下で培養した菌体のカロチノイド含有量は,その培養条件に関係なく,すべての実験においてほぼ一定の値(15μg/g)をを示した. 一方,光照射下で培養した菌体のカロチノイド含有量は80〜140μg/gを示し,光はあきらかにカロチノイド生成を著しく促進した. 5)光照明下で培養した場合,菌体の収量とその菌体のカロチノイド含有量との間には負の勾配を持つ直接関係が成立した。 en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= en-aut-name=ShiroishiMasahide en-aut-sei=Shiroishi en-aut-mei=Masahide kn-aut-name=白石正英 kn-aut-sei=白石 kn-aut-mei=正英 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=6 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=1983 dt-pub=19830312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=大豆の生育に対する根瘤着生の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue= article-no= start-page=4 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=八浜農場における水田経営の合理化過程 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue= article-no= start-page=7 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=1980 dt-pub=19801220 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=カボチャの生育に対するケイ酸カリの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三宅靖人 kn-aut-sei=三宅 kn-aut-mei=靖人 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=38 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=乾田直播栽培水稲の生育におよぼす緩効性肥料の肥効 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三宅靖人 kn-aut-sei=三宅 kn-aut-mei=靖人 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page=36 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=197912 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=干拓新田の水稲生育におよぼす生わら連用の効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三宅靖人 kn-aut-sei=三宅 kn-aut-mei=靖人 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=1 cd-vols= no-issue= article-no= start-page=10 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=197812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=塩害地におけるイネ、タマネギの生育におよぼす苗ほの塩分の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=塩害地でイネ、タマネギを栽培する場合、育苗中の土壌塩分が其の後の生育収量に及ぼす影響について試験を行いつぎに要約する結果を得た。1) イネにおいては育苗中の土壌塩分は其後の生育収量に影響を及ぼさなかった。2) タマネギの場合における塩分地育苗の効果は明らかであった。しかし太苗を使用した場合は抽苔が多く認められたので育苗中の管理に十分な配慮をする必要性が認められた。 en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=三宅靖人 kn-aut-sei=三宅 kn-aut-mei=靖人 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=平岡忠 kn-aut-sei=平岡 kn-aut-mei=忠 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=多田正人 kn-aut-sei=多田 kn-aut-mei=正人 aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小林末子 kn-aut-sei=小林 kn-aut-mei=末子 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=1 article-no= start-page=69 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=1972 dt-pub=1972 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of Gamma Irradiation on the Fat in the Wheat and Rice kn-title=小麦、米の脂質に及ぼすγ-線照射の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=小麦,米にその貯穀害虫の殺虫に必要な量の放射線を照射した時にその脂質に起る変化を調べる目的で,小麦は“マニトバ”と“農林61号”,米は“ささしぐれ”にCo-60を線源としてγ-線を照射し,照射直後及び照射後60日間温室貯蔵した後に脂質について,化学的性質及び脂質酸構成比を調べた. この結果,小麦については50Krad,米については200Kradまでのγ-線照射は60日間以内では,その脂質に殆んど栄養を与えないことを明らかにした。 en-copyright= kn-copyright= en-aut-name=ShiroishiMasahide en-aut-sei=Shiroishi en-aut-mei=Masahide kn-aut-name=白石正英 kn-aut-sei=白石 kn-aut-mei=正英 aut-affil-num=1 ORCID= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=1 article-no= start-page=71 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=1969 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of Gamma Irradiation and Storage on the Content of Sugar in the Onion Bulb. kn-title=タマネギの糖含有量に及ぼすγ-線 照射と貯蔵の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present study was carried out to investigate the effect of gamma irradiation on the content of sugar in onion bulbs during the storage at room temperature and at 1℃. Onion bulbs. Sapporo yellow, were irradiated with the dose of 7000 and 15000 rad from Co-60 gamma source. Takasaki Laboratory, Japan Atomic Energy Research Institute soon after the harvest and after storage for 1 month at room temperature. The experimental result showed that the content of sugar in onion bulbs was not significantly changed by any dose of irradiation and also by temperature during storage. en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= en-aut-name=ShiroishiMasahide en-aut-sei=Shiroishi en-aut-mei=Masahide kn-aut-name=白石正英 kn-aut-sei=白石 kn-aut-mei=正英 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=33 cd-vols= no-issue=1 article-no= start-page=57 end-page=69 dt-received= dt-revised= dt-accepted= dt-pub-year=1969 dt-pub=1969 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Physico-chemical Properties of Syloid and the Effect of its Addition on Pulverized Food kn-title=サイロイドの理化学的性状と粉末食品へのサイロイド添加の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Syloid is a minute crystal of anhydrous sillica, the use of which has been permitted by F.D.A. in 1966 as an anticaking agent for pulverized food. Sillica is essentially an adsorbent, and used for chromatography to isolate various chemical compounds. It is, therefore, anticipated that it may adsorb the nutrients to decrease the nutritive value of food, when used as the food additive. This report describes some physico-chemical properties of syloid, the determination of syloid added to food, and the adsorption of some nutrients. Recovery of syloid, more than 96 per bent, was determined. Nutrients such as amino acids, vitamin C and glucose were scarcely adsorbed by syloid. Thiamine was a little adsorbed only in an alkaline medium. Either denaturation or decomposition of the nutrients was not observed by paper partition chromatography and absorption spectrum. en-copyright= kn-copyright= en-aut-name=TadaMikiro en-aut-sei=Tada en-aut-mei=Mikiro kn-aut-name=多田幹郎 kn-aut-sei=多田 kn-aut-mei=幹郎 aut-affil-num=1 ORCID= en-aut-name=ShiroishiMasahide en-aut-sei=Shiroishi en-aut-mei=Masahide kn-aut-name=白石正英 kn-aut-sei=白石 kn-aut-mei=正英 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 END