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Author Sato, Hiroki| Nakamura, Takao|
Keywords cardiac surgery ultrasonography muscle quality phase angle electrical impedance myography
Published Date 2021-12-04
Publication Title Cureus Journal Of Medical Science
Volume volume13
Issue issue12
Publisher Cureus Inc.
Start Page e20166
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Sato et al.
File Version publisher
PubMed ID 34881132
DOI 10.7759/cureus.20166
Web of Science KeyUT 000728580100020
Related Url isVersionOf https://doi.org/10.7759/cureus.20166
FullText URL fulltext.pdf
Author Takaya, Yoichi| Nakamura, Kazufumi| Nakayama, Rie| Ohtsuka, Hiroaki| Amioka, Naofumi| Kondo, Megumi| Akazawa, Kaoru| Ohno, Yuko| Ichikawa, Keishi| Saito, Yukihiro| Akagi, Satoshi| Yoshida, Masashi| Miyoshi, Toru| Ito, Hiroshi|
Published Date 2021-11-24
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Portfolio
Start Page 22812
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 34819579
DOI 10.1038/s41598-021-02271-6
Web of Science KeyUT 000722365800023
Related Url isVersionOf https://doi.org/10.1038/s41598-021-02271-6
FullText URL fulltext.pdf
Author Nakashima, Mitsutaka| Miyoshi, Toru| Ejiri, Kentaro| Kihara, Hajime| Hata, Yoshiki| Nagano, Toshihiko| Takaishi, Atsushi| Toda, Hironobu| Nanba, Seiji| Nakamura, Yoichi| Akagi, Satoshi| Sakuragi, Satoru| Minagawa, Taro| Kawai, Yusuke| Nishii, Nobuhiro| Fuke, Soichiro| Yoshikawa, Masaki| Nakamura, Kazufumi| Ito, Hiroshi| MUSCAT-HF Study Investigators|
Keywords Estimated plasma volume Heart failure with preserved ejection fraction Luseogliflozin Sodium glucose co-transporter 2 inhibitors Voglibose
Published Date 2021-11-03
Publication Title Esc Heart Failure
Publisher Wiley Periodicals, Inc
ISSN 2055-5822
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors.
File Version publisher
DOI 10.1002/ehf2.13683
Web of Science KeyUT 000714002000001
Related Url isVersionOf https://doi.org/10.1002/ehf2.13683
JaLCDOI 10.18926/AMO/62806
FullText URL 75_6_677.pdf
Author Tani Kazumasa| Mitsui, Takashi| Mishima, Sakurako| Ohira, Akiko| Maki, Jota| Eto, Eriko| Hayata, Kei| Nakamura, Keiichiro| Masuyama, Hisashi|
Abstract Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy.
Keywords endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-12
Volume volume75
Issue issue6
Publisher Okayama University Medical School
Start Page 677
End Page 684
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 34955534
Web of Science KeyUT 000735297900002
NAID 120007180286
FullText URL fulltext.pdf
Author Selvam, Karthik Paneer| Nagahata, Taichi| Kato, Kosuke| Koreishi, Mayuko| Nakamura, Toshiyuki| Nakamura, Yoshimasa| Nishikawa, Takeshi| Satoh, Ayano| Hayashi, Yasuhiko|
Keywords Carbon Nanohorns Cellulose Skin sensitization Composites Bio-compatible
Published Date 2021-10-23
Publication Title Biomaterials Research
Volume volume24
Issue issue1
Publisher Springer Nature
Start Page 18
ISSN 1226-4601
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2020
File Version publisher
PubMed ID 33110624
DOI 10.1186/s40824-020-00194-3
Web of Science KeyUT 000672709800001
Related Url isVersionOf https://doi.org/10.1186/s40824-020-00194-3
FullText URL fulltext.pdf
Author Nakamura, Makoto| Meguri, Yusuke| Ikegawa, Shuntaro| Kondo, Takumi| Sumii, Yuichi| Fukumi, Takuya| Iwamoto, Miki| Sando, Yasuhisa| Sugiura, Hiroyuki| Asada, Noboru| Ennishi, Daisuke| Tomida, Shuta| Fukuda-Kawaguchi, Emi| Ishii, Yasuyuki| Maeda, Yoshinobu| Matsuoka, Ken-Ichi|
Published Date 2021-06-23
Publication Title Scientific Reports
Volume volume11
Issue issue1
Publisher Nature Research
Start Page 13125
ISSN 2045-2322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021
File Version publisher
PubMed ID 34162921
DOI 10.1038/s41598-021-92526-z
Web of Science KeyUT 000669995600012
Related Url isVersionOf https://doi.org/10.1038/s41598-021-92526-z
FullText URL K0006389_abstract_review.pdf K0006389_fulltext.pdf K0006389_summary.pdf
Author Nakamura, Tomoya|
Published Date 2021-03-25
Content Type Thesis or Dissertation
Grant Number 甲第6389号
Granted Date 2021-03-25
Thesis Type Doctor of Philosophy in Dental Science
Grantor 岡山大学
language English
Copyright Holders © Nakamuraet al.
JaLCDOI 10.18926/AMO/61904
FullText URL 75_2_219.pdf
Author Sugiura, Hiroyuki| Nishimori, Hisakazu| Matsuoka, Hirofumi| Nakamura, Keiichiro| Fujii, Keiko| Fujii, Nobuharu | Matsuoka, Ken-ichi | Maeda, Yoshinobu|
Abstract Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor’s treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer.
Keywords acute promyelocytic leukemia endometrial cancer arsenic trioxide synchronous multiple primary malignant tumor chemotherapy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2021-04
Volume volume75
Issue issue2
Publisher Okayama University Medical School
Start Page 219
End Page 224
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33953429
NAID 120007029883
FullText URL fulltext.pdf
Author Asada, Saori| Nishii, Nobuhiro| Shinya, Takayoshi| Miyoshi, Akihito| Morimoto, Yoshimasa| Miyamoto, Masakazu| Nakagawa, Koji| Nakamura, Kazufumi| Morita, Hiroshi| Ito, Hiroshi|
Published Date 2021-03-04
Publication Title PLoS One
Volume volume16
Issue issue3
Publisher Public Library of Science
Start Page e0245502
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Asada et al.
File Version publisher
PubMed ID 33661956
DOI 10.1371/journal.pone.0245502
NAID 120007019113
Web of Science KeyUT 000626604100103
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0245502
FullText URL fulltext20210629-2.pdf
Author Nakayama, Rie| Takaya, Yoichi| Nakamura, Kazufumi| Kondo, Megumi| Kobayashi, Kaoru| Ohno, Yuko| Amioka, Naofumi| Akagi, Satoshi| Yoshida, Masashi| Miyoshi, Toru| Ito, Hiroshi|
Keywords Dispersion Elasticity Myocardium Right ventricular function Shear wave elastography
Note This is an Accepted Manuscript of an article published by Elsevier.
© 2021 Japanese College of Cardiology. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.jjcc.2021.01.015] .|
Published Date 2021-02-07
Publication Title Journal of Cardiology
Volume volume78
Issue issue1
Publisher Elsevier
Start Page 17
End Page 23
ISSN 0914-5087
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
File Version author
PubMed ID 33568315
DOI 10.1016/j.jjcc.2021.01.015
Web of Science KeyUT 000661421700003
Related Url isVersionOf https://doi.org/10.1016/j.jjcc.2021.01.015
FullText URL fulltext20210630-1.pdf
Author Nakamura, Kazufumi| Akagi, Satoshi| Ejiri, Kentaro| Yoshida, Masashi| Miyoshi, Toru| Sakaguchi, Masakiyo| Amioka, Naofumi| Suastika, Luh Oliva Saraswati| Kondo, Megumi| Nakayama, Rie| Takaya, Yoichi| Higashimoto, Yuichiro| Fukami, Kei| Matsubara, Hiromi| Ito, Hiroshi|
Keywords pulmonary artery smooth muscle cells RAGE aptamer
Note This is an Accepted Manuscript published by Elsevier.
©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/|
Published Date 2020-12-30
Publication Title Journal of Cardiology
Volume volume78
Issue issue1
Publisher Elsevier
Start Page 12
End Page 16
ISSN 09145087
NCID AN10070473
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
File Version author
PubMed ID 33386219
DOI 10.1016/j.jjcc.2020.12.009
Web of Science KeyUT 000661421700002
Related Url isVersionOf https://doi.org/10.1016/j.jjcc.2020.12.009
FullText URL fulltext.pdf
Author Nakayama, Rie| Takaya, Yoichi| Nakamura, Kazufumi| Toh, Norihisa| Ito, Hiroshi|
Keywords Shear wave elastography Elasticity Dispersion slope Liver dysfunction Heart failure
Published Date 2021-03-24
Publication Title ESC Heart Failure
Volume volume8
Issue issue3
Publisher Wiley
Start Page 1751
End Page 1758
ISSN 2055-5822
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2021 The Authors
File Version publisher
PubMed ID 33760377
DOI 10.1002/ehf2.13318
NAID 120007004154
Web of Science KeyUT 000631949700001
Related Url isVersionOf https://doi.org/10.1002/ehf2.13318
JaLCDOI 10.18926/CTED/61578
Title Alternative Development of Lessons Based on Multiple Intelligences(MI)Theory
FullText URL cted_011_247_261.pdf
Author NAKAMURA, Saho| IMAI, Yasuyoshi| SAKO, Haruko|
Abstract Society5.0 の到来を迎え,個別最適化された学びや教科横断型学習の拡充等,教育改革が推進されている。これらの教育を実現させ得る理論的なアプローチとして,本稿では,人間の知能を言語,論理数学,音楽,身体運動,空間,対人,内省,博物的という8つの多面的な視点から捉える H.ガードナーの MI 理論(多重知能理論)に着目した。MI 理論に基づく音楽と体育の授業開発を試みた結果,子どもたちは自分の知能の特性を生かし,他者と協働して楽しみながら問題解決をする姿が見て取れた。また,ゴフマンのフレーム理論を援用し考察したところ,授業実践の鍵となったのは,授業の核に〈イメージ〉を設定することであった。以上より,MI 理論に基づく授業実践は激変する教育システムの支柱になり得る可能性が示唆された。
Keywords MI 理論 (Multiple Intelligences Theory) イメージ (Imagination)
Publication Title Bulletin of Center for Teacher Education and Development, Okayama University
Published Date 2021-03-22
Volume volume11
Start Page 247
End Page 261
ISSN 2186-1323
language Japanese
Copyright Holders Copyright © 2021 岡山大学教師教育開発センター
File Version publisher
FullText URL fulltext.pdf
Author Akagi, Satoshi| Ejiri, Kentaro| Kasahara, Shingo| Nakamura, Kazufumi| Ito, Hiroshi|
Keywords vital capacity pulmonary artery pressure lung perfusion and oxygenation
Published Date 2019-02-15
Publication Title Pulmonary Circulation
Volume volume9
Issue issue1
Publisher SAGE Publications
Start Page 2045894019831217
ISSN 2045-8932
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s). 2019
File Version publisher
PubMed ID 30698485
DOI 10.1177/2045894019831217
Web of Science KeyUT 000458818800001
Related Url isVesionOf https://doi.org/10.1177/2045894019831217
JaLCDOI 10.18926/ATM/61436
FullText URL 75_1_63.pdf
Author Tada, Katsuhiko| Miyagi, Yasunari| Nakamura, Kazue| Yorozu, Moe| Fukushima, Emi| Kumazawa, Kazumasa| Nakamura, Makoto| Kageyama, Misao|
Abstract We used a differential equation to identify the biological relationship between the maternal prepregnancy body mass index (BMI) and lactation on postpartum day 4 in Japanese women with neonatal separation. This retro-spective observational study included 252 mothers (135 primiparas, 117 multiparas) whose singleton neonates were admitted to a neonatal ICU. We formulated hypotheses based on breast anatomy to analyze the relation-ship between the expressed milk obtained on postpartum day 4 and the maternal prepregnancy BMI with the following differential equation: y’(x) = k y(x)/x, where k is the constant, x is the prepregnancy BMI, and y is the expressed milk volume. The formula was then obtained as y(x) = axk, where a is the constant. The Akaike information criterion (AIC) was used to estimate the regression equation with the maximum likelihood for primiparas and multiparas. The best criteria for BMI determined by the AIC were 20.89 kg/m2 in primiparas and 20.19 kg/m2 in multiparas. These were the optimal BMI values for lactation, coinciding with the median prepregnancy BMI in the study population (20.78 kg/m2 in primiparas and 20.06 kg/m2 in multiparas). The formula based on biomathematics might help establish the biological relationship between prepregnancy BMI and breastmilk volume.
Keywords biomathematics body mass index expressed milk lactation
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-02
Volume volume75
Issue issue1
Publisher Okayama University Medical School
Start Page 63
End Page 69
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33649615
JaLCDOI 10.18926/AMO/61433
FullText URL 75_1_45.pdf
Author Otsuka, Hiroaki| Miyoshi, Toru| Ejiri, Kentaro| Kohno, Kunihisa| Nakahama, Makoto| Doi, Masayuki| Munemasa, Mitsuru| Murakami, Masaaki| Nakamura, Kazufumi| Ito, Hiroshi|
Abstract Remote ischemic preconditioning (RIPC) is a promising strategy for protecting against ischemic reperfusion injury. This study is a secondary analysis of a randomized study that aimed to evaluate the effect of RIPC on the early increase in serum creatinine (SCr) following percutaneous coronary intervention (PCI), which is associ-ated with contrast-induced acute kidney injury. Patients with stable angina undergoing elective PCI were assigned to control, RIPC, and continuous infusion of nicorandil (nicorandil) groups. The endpoint of this study was the incidence of the early increase in SCr, a predictor of contrast-induced acute kidney injury, which was defined as either a > 20% or absolute increase by 0.3 mg/dl of SCr levels after 24 h of PCI. This study included 220 patients for whom a dataset of SCr values was available. The incidence of the early increase in SCr was significantly lower in the RIPC than in the control (1.3% vs 10.8%, p = 0.03) group, but was not significantly different between the nicorandil and control groups. In multivariate analysis, RIPC remained a significant fac-tor associated with a reduction in the incidence of early increase in SCr. RIPC reduces the incidence of early increase in SCr in patients with stable angina following elective PCI.
Keywords remote ischemic preconditioning stable angina serum creatinine acute kidney injury
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2021-02
Volume volume75
Issue issue1
Publisher Okayama University Medical School
Start Page 45
End Page 53
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2021 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 33649613
FullText URL fulltext.pdf
Author Ichikawa, Keishi| Miyoshi, Toru| Osawa, Kazuhiro| Miki, Takashi| Toda, Hironobu| Ejiri, Kentaro| Yoshida, Masatoki| Nanba, Yusuke| Yoshida, Masashi| Nakamura, Kazufumi| Morita, Hiroshi| Ito, Hiroshi|
Keywords Cardiovascular disease Computed tomography Coronary artery calcium Non-alcoholic fatty liver disease Risk stratification
Published Date 2021-01-07
Publication Title Cardiovascular Diabetology
Volume volume20
Issue issue1
Publisher BMC
Start Page 2021
ISSN 1475-2840
NCID AA12050431
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2021.
File Version publisher
PubMed ID 33413363
DOI 10.1186/s12933-020-01192-4
Web of Science KeyUT 000608278200003
Related Url isVersionOf https://doi.org/10.1186/s12933-020-01192-4
FullText URL fulltext.pdf
Author Sato, Hiroki| Nakamura, Takao| Kusuhara, Toshimasa| Kenichi, Kobara| Kuniyasu, Katsushi| Kawashima, Takaki| Hanayama, Kozo|
Keywords Phase angle Bioelectrical impedance analysis Cole–Cole model Muscle quality
Published Date 2020-10-31
Publication Title Journal of Physiological Sciences
Volume volume70
Issue issue1
Publisher Springer
Start Page 53
ISSN 1880-6546
NCID AA12129145
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Authors
File Version publisher
PubMed ID 33129254
DOI 10.1186/s12576-020-00780-z
Web of Science KeyUT 000587996200002
Related Url isVersionOf https://doi.org/10.1186/s12576-020-00780-z
FullText URL fulltext.pdf
Author Potiszil, Christian| Tanaka, Ryoji| Kobayashi, Katsura| Kunihiro, Tak| Nakamura, Eizo|
Keywords Hayabusa2 Ryugu Sample return Organic matter Albedo. Astrobiology 20, 916–921
Published Date 2020-07-08
Publication Title Astrobiology
Volume volume20
Issue issue7
Publisher Mary Ann Liebert
Start Page 916
End Page 921
ISSN 1531-1074
NCID AA11837332
Content Type Journal Article
language English
Copyright Holders © Christian Potiszil et al., 2020
File Version publisher
PubMed ID 32543220
DOI 10.1089/ast.2019.2198
Web of Science KeyUT 000541711900001
Related Url isVersionOf https://doi.org/10.1089/ast.2019.2198