result 1510 件
FullText URL | fulltext20230418-05.pdf figure20230418-05.pdf |
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Author | Hu, Xinran| Fukui, Yusuke| Feng, Tian| Bian, Zhihong| Yu, Haibo| Morihara, Ryuta| Hu, Xiao| Bian, Yuting| Sun, Hongming| Takemoto, Mami| Nakano, Yumiko| Yunoki, Taijun| Abe, Koji| Yamashita, Toru| |
Keywords | Ischemic stroke Carnosine Middle cerebral artery occlusion Oxidative stress Inflammation Pyroptosis |
Note | ©2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jns.2023.120608. | This fulltext file will be available in Apr. 2024.| |
Published Date | 2023-04-15 |
Publication Title | Journal of the Neurological Sciences |
Volume | volume447 |
Publisher | Elsevier BV |
Start Page | 120608 |
ISSN | 0022-510X |
NCID | AA00703265 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Elsevier B.V. |
File Version | author |
PubMed ID | 36906993 |
DOI | 10.1016/j.jns.2023.120608 |
Web of Science KeyUT | 000956027800001 |
Related Url | isVersionOf https://doi.org/10.1016/j.jns.2023.120608 |
FullText URL | fulltext.pdf |
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Author | Tokushige, Keisuke| Yamashiro, Toshiki| Hirao, Seiya| Abe, Takumi| |
Keywords | 1′H-1,3′-biindole N-electrophilic N-methoxyindoles bisindoles aluminum cross-coupling |
Published Date | 2023-03-03 |
Publication Title | Chemistry |
Volume | volume5 |
Issue | issue1 |
Publisher | MDPI |
Start Page | 452 |
End Page | 462 |
ISSN | 2624-8549 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
DOI | 10.3390/chemistry5010033 |
Web of Science KeyUT | 000959993900001 |
Related Url | isVersionOf https://doi.org/10.3390/chemistry5010033 |
FullText URL | fulltext20230418-04.pdf |
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Author | Okuno, Kyosuke| Isobe, Kazuma| Horibe, Akihiko| Yamada, Yutaka| |
Keywords | Microcapsule n-Tetracosane Silane coupling agent Sol-gel method Thermal energy storage |
Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10765-023-03179-1.| This fulltext file will be available in Mar. 2024.| |
Published Date | 2023-03-11 |
Publication Title | International Journal of Thermophysics |
Volume | volume44 |
Issue | issue5 |
Publisher | Springer Science and Business Media LLC |
Start Page | 69 |
ISSN | 0195-928X |
NCID | AA10619959 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023 |
File Version | author |
DOI | 10.1007/s10765-023-03179-1 |
Web of Science KeyUT | 000948441400001 |
Related Url | isVersionOf https://doi.org/10.1007/s10765-023-03179-1 |
FullText URL | fulltext20230418-03.pdf table20230418-03.pdf figure20230418-03.pdf |
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Author | Kobashi, Yoshimitsu| Inagaki, Ryuya| Shibata, Gen| Ogawa, Hideyuki| |
Keywords | Dual fuel engine ozone natural gas diesel fuel pilot injection thermal efficiency exhaust emissions |
Note | This is an Accepted Manuscript of an article published by SAGE Publications.| |
Published Date | 2023-3-24 |
Publication Title | International Journal of Engine Research |
Publisher | SAGE Publications |
ISSN | 1468-0874 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © IMechE 2023. |
File Version | author |
DOI | 10.1177/14680874231162144 |
Web of Science KeyUT | 000955729900001 |
Related Url | isVersionOf https://doi.org/10.1177/14680874231162144 |
FullText URL | fulltext20230418-02.pdf |
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Author | Watanabe, Takaichi| Oe, Emiho| Mizutani, Yuna| Ono, Tsutomu| |
Published Date | 2023-03-23 |
Publication Title | Soft Matter |
Volume | volume19 |
Issue | issue15 |
Publisher | Royal Society of Chemistry |
Start Page | 2745 |
End Page | 2754 |
ISSN | 1744-683X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © The Royal Society of Chemistry 2023 |
File Version | publisher |
PubMed ID | 36987711 |
DOI | 10.1039/d3sm00112a |
Web of Science KeyUT | 000959187800001 |
Related Url | isVersionOf https://doi.org/10.1039/d3sm00112a |
FullText URL | fulltext20230414-01.pdf |
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Author | 今津 勝紀| |
Published Date | 2023-03 |
Publication Title | 島根県古代文化センター研究論集 |
Volume | volume30 |
Start Page | 221 |
End Page | 238 |
language | Japanese |
File Version | author |
FullText URL | fulltext20230418-01.pdf |
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Author | Hirano, Masaki| Muto, Yuki| Kuroda, Masahiro| Fujiwara, Yuta| Sasaki, Tomoaki| Kuroda, Kazuhiro| Kamizaki, Ryo| Imajoh, Satoshi| Tanabe, Yoshinori| E. Al-Hammad, Wlla| Nakamitsu, Yuki| Shimizu, Yudai| Sugimoto, Kohei| Oita, Masataka| Sugianto, Irfan| O. Bamgbose, Babatunde| |
Keywords | MAVRIC SL metal artifacts implant phantom MRI |
Published Date | 2023-1-24 |
Publication Title | Experimental and Therapeutic Medicine |
Volume | volume25 |
Issue | issue3 |
Publisher | Spandidos Publications |
Start Page | 109 |
ISSN | 1792-0981 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © Hirano et al. |
File Version | publisher |
PubMed ID | 36793326 |
DOI | 10.3892/etm.2023.11808 |
Web of Science KeyUT | 000948969100001 |
Related Url | isVersionOf https://doi.org/10.3892/etm.2023.11808 |
FullText URL | fulltext.pdf |
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Author | Sasaki, Ryo| Matsuoka, Chika| Yamashita, Toru| Kinomura, Masaru| Abe, Koji| |
Keywords | dialysis disequilibrium syndrome involuntary movement renal failure myoclonus hemodialysis |
Published Date | 2023-03-13 |
Publication Title | Cureus |
Volume | volume15 |
Issue | issue3 |
Publisher | CUREUS INC |
Start Page | e36104 |
ISSN | 2168-8184 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 Sasaki et al. |
File Version | publisher |
DOI | 10.7759/cureus.36104 |
Web of Science KeyUT | 000957269900011 |
Related Url | isVersionOf https://doi.org/10.7759/cureus.36104 |
FullText URL | fulltext.pdf |
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Author | Sako, Hidefumi| Omori, Kazuhiro| Nakayama, Masaaki| Mandai, Hiroki| Ideguchi, Hidetaka| Yoshimura-Nakagawa, Saki| Sakaida, Kyosuke| Nagata-Kamei, Chiaki| Kobayashi, Hiroya| Ishii, Satoki| Ono, Mitsuaki| Ibaragi, Soichiro| Yamamoto, Tadashi| Suga, Seiji| Takashiba, Shogo| |
Keywords | synthetic (+)-terrein periodontitis TNF-α |
Published Date | 2023-03-03 |
Publication Title | Journal of Fungi |
Volume | volume9 |
Issue | issue3 |
Publisher | MDPI |
Start Page | 314 |
ISSN | 2309-608X |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
PubMed ID | 36983482 |
DOI | 10.3390/jof9030314 |
Web of Science KeyUT | 000960078500001 |
Related Url | isVersionOf https://doi.org/10.3390/jof9030314 |
FullText URL | fulltext.pdf |
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Author | Gathinji, Peter Kiiru| Yousofi, Zabiallah| Akada, Karin| Wali, Ajmal| Nishino, Naoki| |
Keywords | airborne dust blood metabolites Jersey cows microbiota milk |
Published Date | 2023-03-16 |
Publication Title | Veterinary Sciences |
Volume | volume10 |
Issue | issue3 |
Publisher | MDPI |
Start Page | 226 |
ISSN | 2306-7381 |
Content Type | Journal Article |
language | English |
OAI-PMH Set | 岡山大学 |
Copyright Holders | © 2023 by the authors. |
File Version | publisher |
PubMed ID | 36977265 |
DOI | 10.3390/vetsci10030226 |
Web of Science KeyUT | 000960149500001 |
Related Url | isVersionOf https://doi.org/10.3390/vetsci10030226 |
JaLCDOI | 10.18926/AMO/65155 |
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FullText URL | 77_2_227.pdf |
Author | Obayashi, Atsuto| Aoki, Kazuma| Wada, Tadayoshi| Furuie, Hiromi | Kuraoka, Kazuya| Hamamoto, Takao| Tatsukawa, Takaharu| |
Abstract | We describe the use of the tyrosine kinase inhibitor lenvatinib in a patient with brain tumor metastases from anaplastic thyroid carcinoma (ATC). A 52-year-old Japanese male presented with consciousness loss. Imaging revealed a thyroid tumor and multiple brain lesions. After the brain tumor’s resection, pathology results provided the diagnosis of ATC. Total thyroidectomy was performed, followed by whole-brain irradiation. Additional brain lesions later developed, and lenvatinib therapy was initiated with no remarkable complications. However, the treatment effects were limited, and the patient died 2 months after starting lenvatinib, 202 days after the initial brain surgery. Relevant literature is discussed. |
Keywords | anaplastic thyroid carcinoma brain metastasis lenvatinib |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 227 |
End Page | 232 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094963 |
Web of Science KeyUT | 000982563800006 |
JaLCDOI | 10.18926/AMO/65154 |
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FullText URL | 77_2_221.pdf |
Author | Iriyoshi, Hiroki| Sada, Ken-ei| Miyauchi, Atsushi| Yamamoto, Hirotaka| Hashimoto, Daisuke| Nojima, Shigeru| Yamanaka, Shingo| Kawamura, Masafumi| Oka, Satoshi| |
Abstract | Several previous case reports have shown that patients with immunoglobulin D (IgD) multiple myeloma (MM) can be withdrawn from hemodialysis, however, the characteristics that can predict withdrawal in these patients have not yet been elucidated. A 57-year-old Japanese woman required hemodialysis because of renal dysfunction due to IgD-λ and Bence Jones protein-λ MM. Bortezomib-based chemotherapy nine days after admission led to her withdrawal from hemodialysis on Day 50. In our case-based review, younger age and early initiation of bortezomib-based chemotherapy emerged as possible predictors of successful hemodialysis withdrawal. |
Keywords | IgD-type multiple myeloma acute renal dysfunction urinary protein hemodialysis bortezomib |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 221 |
End Page | 225 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094962 |
Web of Science KeyUT | 000982563800005 |
JaLCDOI | 10.18926/AMO/65153 |
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FullText URL | 77_2_215.pdf |
Author | Washio, Kana| Tamefusa, Kosuke| Ochi, Motoharu| Kanamitsu, Kiichiro| Ishida, Hisashi| Fujiwara, Kaori| Nishida, Kenji| Tamai, Kei| Washio, Yosuke| Yoshimoto, Junko| Noda, Takuo| Tsukahara, Hirokazu| |
Abstract | Among patients with transient abnormal myelopoiesis (TAM) associated with Down syndrome, approximately 20% die within 6 months from multiorgan failure, especially liver fibrosis. We experienced three children with TAM who had low white blood cell counts but increased bilirubin levels. Here, we discuss the detailed clinical courses of these patients, including the pathological findings of liver biopsies. Our cases, together with previous literature, suggest that liver biopsy can be performed safely and provides useful information, especially regarding disease activities, and that low-dose cytarabine is a reasonable option to prevent early death in TAM patients with liver dysfunction. |
Keywords | liver biopsy transient abnormal myelopoiesis Down syndrome low-dose cytarabine |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 215 |
End Page | 220 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094961 |
Web of Science KeyUT | 000982563800004 |
JaLCDOI | 10.18926/AMO/65152 |
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FullText URL | 77_2_209.pdf |
Author | Sakamoto, Masaki| Teraishi, Fuminori| Shigeyasu Kunitoshi| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
Abstract | A 70-year-old male with anal pain and fever was diagnosed with rectal cancer perforation and abscess in the right gluteus maximus (GM) muscle. He underwent a transverse colon colostomy followed by preoperative capecitabine+oxaliplatin. Some local control was achieved but a residual abscess was observed in the right GM muscle. To secure circumferential resection margin by tumor reduction, he received chemoradiotherapy as total neoadjuvant therapy (TNT) and underwent laparoscopic abdominoperineal resection, D3 lymph node dissection, combined coccyx resection, and partial resection of the right GM muscle. The skin defect and pelvic dead space were filled with a right lateral vastus lateral great muscle flap. Histopathologically, the resected specimen showed no tumor cells in the primary tumor or lymph nodes, indicating a pathological complete response (pCR). This case suggests that TNT might improve the R0 resection and pCR rates and overall survival. |
Keywords | locally advanced rectal cancer total neoadjuvant therapy lateral vastus lateral great muscle flap |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 209 |
End Page | 213 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094960 |
Web of Science KeyUT | 000982563800003 |
JaLCDOI | 10.18926/AMO/65151 |
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FullText URL | 77_2_203.pdf |
Author | Fukushima, Shinnosuke| Hagiya, Hideharu| Iio, Koji| Honda, Hiroyuki| Ishida, Tomoharu| Nagaoka, Hirokazu| Hasegawa, Kou| Otsuka, Fumio| |
Abstract | Granulicatella species are rare, nutritionally variant streptococci that cause infective endocarditis. Their clinical and microbiological characteristics remain unknown. We reviewed five years of Granulicatella cases in our hospital database (Jan 2017-Jun 2022), finding 6 Granulicatella adiacens cases and 1 Granulicatella elegans case. Clinical backgrounds and bacteremia sources were diverse; 3 cases developed polymicrobial bacteremia. Antimicrobial testing showed non-susceptibility to penicillin G in 4 of 7 cases (57.1%), and high susceptibility to carbapenems and vancomycin in all cases. Determining optimal antibiotic therapy for Granulicatella infections is vital in this era of antimicrobial resistance. |
Keywords | antimicrobial resistance bacteremia Granulicatella species nutritionally variant streptococci |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 203 |
End Page | 207 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094959 |
Web of Science KeyUT | 000982563800002 |
JaLCDOI | 10.18926/AMO/65150 |
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FullText URL | 77_2_199.pdf |
Author | Nagano, Tomohiro| Hosokawa, Shinobu| Miyahara, Hideaki| Yamada, Kotaro| Umeno, Takayuki| Kano, Hirohisa| Kayatani, Hiroe| Sakugawa, Makoto| Takehisa, Yasushi| Takenaka, Tadasu| Takeuchi, Makoto| Bessho, Akihiro| |
Abstract | Meningitis-retention syndrome (MRS) is the combination of aseptic meningitis and acute urinary retention that occurs in the absence of other neurological diseases. The cause(s) of MRS remain unclear. A 57-year-old Japanese woman was referred to our hospital for the evaluation of persistent fever and headache. The fever’s cause was initially unclear, but the presence of urinary retention raised concern about possible aseptic meningitis despite no physical indications of meningeal irritation. Only typical cases of MRS have been reported thus far to our knowledge, and it is important that clinicians are aware of MRS when it presents in this atypical form. |
Keywords | meningitis-retention syndrome aseptic meningitis acute urinary retention |
Amo Type | Case Report |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 199 |
End Page | 201 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094958 |
Web of Science KeyUT | 000982503800010 |
JaLCDOI | 10.18926/AMO/65149 |
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FullText URL | 77_2_193.pdf |
Author | Ikeda, Tomohiro| Noma, Kazuhiro| Okura, Kazuki| Katayama, Sho| Takahashi, Yusuke| Maeda, Naoaki| Tanabe, Shunsuke| Wakita, Akiyuki| Hamada, Masanori| Fujiwara, Toshiyoshi| Senda, Masuo| |
Abstract | This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759). Furthermore, fewer patients whose CS-30 score was greater than 16 (the cutoff value defined based on 6MWT) experienced pneumonia in their postoperative course. These results suggest that exercise tolerance could be assessed using CS-30, and its cutoff value may be useful in predicting postoperative pneumonia risk. |
Keywords | esophageal cancer exercise tolerance rehabilitation |
Amo Type | Short Communication |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 193 |
End Page | 197 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094957 |
Web of Science KeyUT | 000982503800009 |
JaLCDOI | 10.18926/AMO/65148 |
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FullText URL | 77_2_185.pdf |
Author | Sugihara, Akiko| Okada, Ayumi| Horiuchi, Makiko| Yabe, Mayumi| Shigeyasu, Yoshie| Fujii, Chikako| Tanaka, Chie| Yorifuji, Takashi| Tsukahara, Hirokazu| |
Abstract | Psychosomatic disorders are influenced by psychosocial factors such as interpersonal relationships. Coping behaviors, especially in frustrating situations, reflect a patient’s ability to cope with stress, and it is important to assess these behaviors for the treatment of psychosomatic diseases. This study aimed to clarify the interpersonal relationships and coping behaviors of pediatric patients with psychosomatic diseases during frustrating situations simulated using the Rosenzweig Picture-Frustration study. This retrospective study included 126 patients (41 male, 85 female) with an average age of 12.9 (6-16) years who were consulted at the Department of Pediatric Psychosomatic Medicine at Okayama University Hospital from 2013 to 2018 and underwent the P-F study. Each score was compared with a standardization sample. The mean group conformity rating did not differ significantly between the participants and healthy children. Compared with healthy children, those with psychosomatic diseases were less likely to explain their perspective. The children with psychosomatic disorders responded to frustrating situations in a sensible and age-appropriate manner. However, they were less likely to respond by explaining their perspective to protect themselves. |
Keywords | psychosomatic disorder picture-frustration study children projective technique group conformity rating |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 185 |
End Page | 192 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094956 |
Web of Science KeyUT | 000982503800008 |
JaLCDOI | 10.18926/AMO/65147 |
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FullText URL | 77_2_179.pdf |
Author | Kondo, Hidenori| Saito, Taichi| Nakahara, Ryuichi| Nakamichi, Ryo| Shimamura, Yasunori| Harada, Ryozo| Imatani, Junya| Ozaki, Toshifumi| |
Abstract | Rupture of the extensor pollicis longus (EPL) tendon is a known complication after undisplaced distal radius fracture (DRF). However, no report has revealed the relationship between EPL tendon rupture and the fracture pattern. Thus, this study aimed to investigate the characteristics of fractures at risk of EPL tendon rupture using fracture line mapping of undisplaced DRFs. This study used computed tomography imaging data of undisplaced DRFs with (n=18) and without EPL tendon rupture (n=52). Fracture lines obtained from 3D reconstruction data were drawn manually after matching with a 2D template wrist model. Fracture maps represented the fracture line distribution by superimposing the fracture lines of all 70 patients. Heat maps showed the relative frequency of the fracture lines as a gradual color change. Fracture lines of cases with EPL tendon rupture were concentrated in the proximal border of Lister’s tubercle. By contrast, fracture lines of cases without EPL tendon rupture were relatively dispersed. |
Keywords | distal radius fracture rupture of extensor pollicis longus tendon fracture mapping |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 179 |
End Page | 184 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094955 |
Web of Science KeyUT | 000982503800007 |
JaLCDOI | 10.18926/AMO/65146 |
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FullText URL | 77_2_169.pdf |
Author | Inoue, Kanae| Fujita, Rio| Nagahara, Takatoshi| Murakami, Shiho| Nagai, Yuta| Moriwake, Rina| Miyake, Nozomi| Wakuta, Akiko| Kariyama, Kazuya| Nishimura, Mamoru| Nouso, Kazuhiro| |
Abstract | Alcoholic liver disease is a risk factor for non-virus-related hepatocellular carcinoma (HCC), which is increasing in prevalence. This study aimed to identify the factors for recovery from alcoholic liver failure. Sixty-two consecutive patients hospitalized for alcoholic liver failure at Okayama City Hospital were enrolled. The characteristics of patients who survived to the 1-month follow-up and whose liver function improved to Child–Pugh A at 3 months (CPA3) and 12 months (CPA12) were compared with the rest of the patients. The survivors at 1 month (50 patients) were significantly younger than the deceased patients and had better liver and renal function with higher levels of γ-glutamyl transferase (GGT). The same factors, except renal function, were correlated with achieving CPA3. High AST, ALT, and GGT levels as well as short spleen length, total abstinence, and good Child–Pugh scores at admission were identified as factors for achieving CPA12. The extent of alcohol intake before admission was not identified as a risk factor in any analysis. In conclusion, baseline liver function is crucial for survival and achieving CPA3, whereas high transaminase and γ-GTP levels, the absence of splenomegaly, and total abstinence are significant factors for achieving CPA12. |
Keywords | alcoholic liver failure risk factors recovery |
Amo Type | Original Article |
Publication Title | Acta Medica Okayama |
Published Date | 2023-04 |
Volume | volume77 |
Issue | issue2 |
Publisher | Okayama University Medical School |
Start Page | 169 |
End Page | 177 |
ISSN | 0386-300X |
NCID | AA00508441 |
Content Type | Journal Article |
language | English |
Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
File Version | publisher |
Refereed | True |
PubMed ID | 37094954 |
Web of Science KeyUT | 000982503800006 |