ホルモン失調性胃潰瘍の実験的研究 〔第I編〕 ホルモン失調性胃潰瘍の粘膜病変と血管性変化の関係

Ulceration and disturbances of circulation in the rat's stomach wall were induced by adrenalectomy, hypophysectomy. and changes of these specimen were studied by infusion of india ink benzidine staining (Campbell-Wake's method), and X-ray photography of blood vessels and capillaries. 1. After adrenalectomy the bleeding, erosion and ulcer were found on the stomach wall. 2. As chief changes of the blood vessels the venous congestion and the bleeding preceded the destruction of mucosa. 3. These abnormalities of blood vessels and ulceration were prevented by administration of 0.9% NaCl solution and adrenocortical hormone (cortisone). 4. Vagotomy prevented the circulatory disturbance and ulceration of the adrenalectomized rats. 5. Combined extirpation of pituitary and adrenals produced more marked changes of the blood vessels compared to adrenalectomy alone. 6. After hypephysectomy and adrenalectomy administration of cortisone or 0.9% NaCl solution could not prevent the change of blood vessels, on the other hand administration of 5% glucose solution recovered these changes. 7. If bilateral vagi were previously cut, the congestion and bleeding did not occurred even after hypophysectomy and adrenalectomy.