result 47798 件
| JaLCDOI | 10.18926/AMO/54595 |
|---|---|
| FullText URL | 70_5_371.pdf |
| Author | Noda, Yasuko| Masumizu, Toshiki| Mori, Akitane| |
| Abstract | Methylguanidine (MG) is a known nephrotoxin and neurotoxin, and an intracisternal injection of MG can induce convulsions in experimental animals. In this in vitro study, we examined the inhibitory effects of the antiepileptic agent zonisamide (ZNS) on hydroxyl radicals (•OH) generated from MG by using an electron spin resonance (ESR) technique. ZNS scavenged •OH generated from MG in a dose-dependent manner through direct scavenging during the auto-oxidation of MG. The rate constant of ZNS reacting with the •OH was at a near diffusion-controlled rate. These findings indicate that ZNS might detoxify MG and could thus protect against convulsive disorders. |
| Keywords | methylguanidine zonisamide convulsions hydroxyl radical electron spin resonance |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 371 |
| End Page | 375 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777429 |
| Web of Science KeyUT | 000388098700006 |
| JaLCDOI | 10.18926/AMO/54594 |
|---|---|
| FullText URL | 70_5_363.pdf |
| Author | Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Fujiwara, Toshiyoshi| |
| Abstract | Sarcopenia following liver surgery has been reported as a predictor of poor prognosis. Here we investigated predictors of outcomes in patients with hepatocellular carcinoma (HCC) and attempted to establish a new comprehensive preoperative assessment protocol. We retrospectively analyzed the cases of 254 patients who underwent curative hepatectomy for HCC with Child-Pugh classification A at our hospital between January 2007 and December 2013. Sarcopenia was evaluated by computed tomography measurement. The influence of sarcopenia on outcomes was evaluated. We used multivariate analyses to assess the impact of prognostic factors associated with outcomes, including sarcopenia. Of the 254 patients, 118 (46.5%) met the criteria for sarcopenia, and 32 had an American Society of Anesthesiologists (ASA) physical status ≥3. The sarcopenic group had a significantly lower 5-year overall survival rate than the non-sarcopenic group (58.2% vs. 82.4% , p＝0.0002). In multivariate analyses of prognostic factors, sarcopenia was an independent predictor of poor survival (hazard ratio [HR]＝2.28, p＝0.002) and poor ASA status (HR＝3.17, p＝0.001). Sarcopenia and poor ASA status are independent preoperative predictors for poor outcomes after hepatectomy. The preoperative identification of sarcopenia and ASA status might enable the development of comprehensive approaches to assess surgical eligibility. |
| Keywords | sarcopenia American Society of Anesthesiologists physical status hepatectomy hepatocellular carcinoma prognostic factor |
| Amo Type | Original Articles |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 363 |
| End Page | 370 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777428 |
| Web of Science KeyUT | 000388098700005 |
| JaLCDOI | 10.18926/AMO/54593 |
|---|---|
| FullText URL | 70_5_353.pdf |
| Author | Katayama, Akihiko| Miyatake, Nobuyuki| Nishi, Hiroyuki| Ujike, Kazuhiro| Hashimoto, Hiroo| Kurato, Risa| Koumoto, Kiichi| |
| Abstract | In a longitudinal study, we examined the link between changes in physical activity and changes in health-related quality of life (HRQOL) in patients on chronic hemodialysis. Seventy-one patients (43 males, 28 females; aged 70.9±10.6 years) on chronic hemodialysis in September 2013 were enrolled. The data of the 43 patients whose complete measurements were taken again in September 2014 were used for the longitudinal analysis. Clinical parameters including age, height, dry weight, duration of hemodialysis, blood pressure (BP), blood triglyceride and HDL cholesterol levels, physical activity, and HRQOL were evaluated. Physical activity was measured by a tri-accelerometer, and HRQOL was evaluated by the EuroQol questionnaire (EQ-5D). In the first cross-sectional analysis, EQ-5D scores were significantly correlated with daily step counts (steps per day) on all days and non-hemodialysis days. In the second longitudinal analysis, in the women, changes in EQ-5D scores were positively correlated with changes in daily step counts on all days. In all patients, changes in EQ-5D were weakly and negatively correlated with changes in physical activity (1-3 METs: min per day) on hemodialysis days. Promoting daily physical activity may improve the HRQOL in patients on chronic hemodialysis, especially in women. |
| Keywords | hemodialysis health related quality of life (HRQOL) physical activity |
| Amo Type | Original Articles |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 353 |
| End Page | 361 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777427 |
| Web of Science KeyUT | 000388098700004 |
| JaLCDOI | 10.18926/AMO/54592 |
|---|---|
| FullText URL | 70_5_345.pdf |
| Author | Maruyama, Hidehiko| Nakata, Yusei| Kanazawa, Akane| Kikkawa, Kiyoshi| |
| Abstract | We sought to clarify the survival and neurodevelopmental outcomes of very low birth weight infants (VLBWIs) and to identify risk factors for death or neurodevelopmental impairment (NDI) in VLBWIs at our hospital. The total study population was 217 infants born in 2005-2012 weighing ≤1,500 g. We compared their outcomes with those from previous reports analyzed the causes of death. Risk factors for death after discharge or NDI were evaluated by a multivariate logistic regression analysis. The incidences of death or NDI reported revealed in this study and the database of Neonatal Research Network of Japan were 25.3% and 19.6% (p＝0.039), respectively. The main causes of death before discharge were intraventricular hemorrhage, sepsis, and persistent pulmonary hypertension of the newborn. The significant risk factors for death after discharge or NDI were early gestational age (weeks) and periventricular leukomalacia (adjusted odds ratio [95% confidence interval, p-value], 0.72 [0.54-0.94, 0.017] and 6.90 [1.35-38.25, 0.021], respectively). These factors must be addressed in order to improve treatment strategies for VLBWIs. |
| Keywords | intraventricular hemorrhage periventricular leukomalacia persistent pulmonary hypertension of the newborn sepsis very low birth weight infants |
| Amo Type | Original Articles |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 345 |
| End Page | 352 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777426 |
| Web of Science KeyUT | 000388098700003 |
| JaLCDOI | 10.18926/AMO/54591 |
|---|---|
| FullText URL | 70_5_339.pdf |
| Author | Miyata, Manabu| Nakahara, Ryuichi| Hamasaki, Ichiro| Hasebe, Satoshi| Furuse, Takashi| Ohtsuki, Hiroshi| |
| Abstract | Although a 0.3 Bangerter filter, which reduces visual acuity, is frequently used for treating moderate amblyopia, the effects on gross stereopsis are not well known. This study quantitatively evaluated whether gross stereopsis is degraded by a Bangerter filter. Seven healthy subjects (median age: 29 years) participated in this psychophysical study. Targets with crossed disparities of 1°, 2°, 3°, 4°, and 5° were randomly presented on a three-dimensional television display. The subjects indicated the point at which the targets popped out from the television screen (matching method). The distance from the screen to the point was defined as the degree of stereopsis. This experiment was performed with and without a 0.3 Bangerter filter. The corrected monocular visual acuities were decreased to about 20/63 by the filter in all subjects. No significant difference was observed for any of the disparities (1°-5°), between the degree of stereopsis visualized with and without filters for either the dominant or the non-dominant eye. The degree of stereopsis was not degraded by the reduced visual acuity induced by the use of 0.3 Bangerter filters. In this regard, the use of 0.3 Bangerter filters may be considered safer than occlusion eye patches for the patients with normal binocular vision. |
| Keywords | amblyopia Bangerter filter binocular vision stereopsis |
| Amo Type | Original Articles |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 339 |
| End Page | 344 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777425 |
| Web of Science KeyUT | 000388098700002 |
| JaLCDOI | 10.18926/AMO/54590 |
|---|---|
| FullText URL | 70_5_331.pdf |
| Author | Iida, Atsuyoshi| Nosaka, Nobuyuki| Yumoto, Tetsuya| Knaup, Emily| Naito, Hiromichi| Nishiyama, Chihiro| Yamakawa, Yasuaki| Tsukahara, Kohei| Terado, Michihisa| Sato, Keiji| Ugawa, Toyomu| Nakao, Atsunori| |
| Abstract | In recent years, it has become evident that molecular hydrogen is a particularyl effective treatment for various disease models such as ischemia-reperfusion injury; as a result, research on hydrogen has progressed rapidly. Hydrogen has been shown to be effective not only through intake as a gas, but also as a liquid medication taken orally, intravenously, or locally. Hydrogenʼs effectiveness is thus multifaceted. Herein we review the recent research on hydrogen-rich water, and we examine the possibilities for its clinical application. Now that hydrogen is in the limelight as a gaseous signaling molecule due to its potential ability to inhibit oxidative stress signaling, new research developments are highly anticipated. |
| Keywords | hydrogen antioxidant effect medical gas gaseous signaling molecule clinical tests |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 331 |
| End Page | 337 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777424 |
| Web of Science KeyUT | 000388098700001 |
| Author | 岡山大学大学院法務研究科| |
|---|---|
| Published Date | 2016-09 |
| Publication Title | Okayama Law Review |
| Volume | volume17 |
| Content Type | Others |
| Author | 岡山大学大学院法務研究科| |
|---|---|
| Published Date | 2016-09 |
| Publication Title | Okayama Law Review |
| Volume | volume17 |
| Content Type | Others |
| Author | 岡山大学大学院法務研究科| |
|---|---|
| Published Date | 2016-09 |
| Publication Title | Okayama Law Review |
| Volume | volume17 |
| Content Type | Others |
| JaLCDOI | 10.18926/OLR/54586 |
|---|---|
| Title Alternative | The Brief and the Legal Expense in Civil Procedure |
| FullText URL | olr_017_113_122.pdf |
| Author | Hori, Kiyofumi| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 113 |
| End Page | 122 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856014 |
| JaLCDOI | 10.18926/OLR/54585 |
|---|---|
| Title Alternative | The Legality of the Tax Pending in the Fixed Assets Tax - Necessity, Argumentaion, Proposal - |
| FullText URL | olr_017_097_112.pdf |
| Author | Takahara, Naruaki| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 97 |
| End Page | 112 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856013 |
| JaLCDOI | 10.18926/OLR/54584 |
|---|---|
| Title Alternative | Local Educational System and its Various Issures - Change of National System of Board of Education - |
| FullText URL | olr_017_085_095.pdf |
| Author | Soda, Kayoko| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 85 |
| End Page | 95 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856012 |
| JaLCDOI | 10.18926/OLR/54583 |
|---|---|
| Title Alternative | Problems for Registration List of Persons Needing Assistance for Evacuation |
| FullText URL | olr_017_079_084.pdf |
| Author | Yabuki, Ryojiro| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 79 |
| End Page | 84 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856011 |
| JaLCDOI | 10.18926/OLR/54582 |
|---|---|
| Title Alternative | Efforts for the Safe Evacuation of Persons Needing Assistance in Bizen City |
| FullText URL | olr_017_073_078.pdf |
| Author | Okamura, Takumi| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 73 |
| End Page | 78 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856010 |
| JaLCDOI | 10.18926/OLR/54581 |
|---|---|
| Title Alternative | Efforts for the Safe Evacuation of Persons Needing Assistance in Setouchi City |
| FullText URL | olr_017_061_071.pdf |
| Author | Budou, Yasunari| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 61 |
| End Page | 71 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856009 |
| JaLCDOI | 10.18926/OLR/54580 |
|---|---|
| Title Alternative | Regulations and Problems for Common Use of Personal Data of Persons Needing Assistance for Evacuation |
| FullText URL | olr_017_039_059.pdf |
| Author | Nakamura, Makoto| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 39 |
| End Page | 59 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856008 |
| JaLCDOI | 10.18926/OLR/54579 |
|---|---|
| Title Alternative | A Note from One-year Experience as Fixed-term Public Servant - Legal Affairs Seen from Inside of Local Government - |
| FullText URL | olr_017_031_038.pdf |
| Author | Oyama, Ryo| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 31 |
| End Page | 38 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856007 |
| JaLCDOI | 10.18926/OLR/54578 |
|---|---|
| Title Alternative | A Note on the Continuing Legal Education Program for In-house Lawyers（Part 3） |
| FullText URL | olr_017_019_030.pdf |
| Author | Fujimoto, Kazunari| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 19 |
| End Page | 30 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856006 |
| JaLCDOI | 10.18926/OLR/54577 |
|---|---|
| Title Alternative | The Validity of the Special Clause Deducting Money from Security Deposit |
| FullText URL | olr_017_001_017.pdf |
| Author | Shuutou, Hidenari| |
| Publication Title | Okayama Law Review |
| Published Date | 2016-09 |
| Volume | volume17 |
| Start Page | 1 |
| End Page | 17 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005856005 |
| Author | 岡山大学大学院法務研究科| |
|---|---|
| Published Date | 2016-09 |
| Publication Title | Okayama Law Review |
| Volume | volume17 |
| Content Type | Others |
