result 3070 件
| FullText URL | GutPathog_5_1_36.pdf |
|---|---|
| Author | Dhira Rani Saha| Guin, Sucharita| Krishnan, Rajendran| Nag, Dhrubajyoti| Koley, Hemanta| Shinoda, Sumio| Ramamurthy, Thandavarayan| |
| Published Date | 2013-12-03 |
| Publication Title | Gut Pathogens |
| Volume | volume5 |
| Issue | issue1 |
| Publisher | BioMed Central |
| Start Page | 36 |
| ISSN | 17574749 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 24294997 |
| DOI | 10.1186/1757-4749-5-36 |
| Web of Science KeyUT | 000328551200001 |
| Related Url | isVersionOf https://doi.org/10.1186/1757-4749-5-36 |
| FullText URL | Front_Microbiol_7_1250.pdf |
|---|---|
| Author | Ghosh, Raikamal| Sharma, Naresh C.| Halder, Kalpataru| Bhadra, Rupak K.| Chowdhury, Goutam| Pazhani, Gururaja P.| Shinoda, Sumio| Mukhopadhyay, Asish K.| Nair, G. Balakrish| Ramamurthy, Thadavarayan| |
| Keywords | V.cholerae O139 ribotypes CT genotype CTX prophage PFGE |
| Published Date | 2016-08-09 |
| Publication Title | frontiers in Microbiology |
| Volume | volume7 |
| Publisher | Frontiers Media S.A. |
| Start Page | 1250 |
| ISSN | 1664302X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 27555841 |
| DOI | 10.3389/fmicb.2016.01250 |
| Web of Science KeyUT | 000381079700001 |
| Related Url | isVersionOf https://doi.org/10.3389/fmicb.2016.01250 |
| FullText URL | Nucleic _Acids_Res_44_12_5658.pdf |
|---|---|
| Author | Bhupesh Kumar Thakur| Dasgupta, Nirmalya| Ta, Atri| Das, Santasabuj| |
| Published Date | 2016-04-07 |
| Publication Title | Nucleic Acids Research |
| Volume | volume44 |
| Issue | issue12 |
| Publisher | Oxford University Press |
| Start Page | 5658 |
| End Page | 5672 |
| ISSN | 03051048 |
| NCID | AA00760269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 27060138 |
| DOI | 10.1093/nar/gkw189 |
| Web of Science KeyUT | 000381210900019 |
| Related Url | isVersionOf https://doi.org/10.1093/nar/gkw189 |
| FullText URL | Front_Microbiol_4_144.pdf |
|---|---|
| Author | Chowdhury, Goutam| Joshi, Sangeeta| Bhattacharya, Sanjay| Sekar, Uma| Birajdar, Balaji| Bhattacharyya, Arpita| Shinoda, Sumio| Ramamurthy, Thandavarayan| |
| Note | This work was supported by the Japan Initiative for Global Research Network for Infectious Diseases, Ministry of Education, Culture, Sports, Science and Technology, Japan.| |
| Published Date | 2016-02-11 |
| Publication Title | frontiers in Microbiology |
| Volume | volume7 |
| Publisher | Frontiers Research Foundation |
| Start Page | 144 |
| ISSN | 1664302X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 26904017 |
| DOI | 10.3389/fmicb.2016.00144 |
| Web of Science KeyUT | 000443434600001 |
| Related Url | isVersionOf https://doi.org/10.3389/fmicb.2016.00144 |
| JaLCDOI | 10.18926/AMO/56645 |
|---|---|
| FullText URL | 73_2_101.pdf |
| Author | Iida, Atsuyoshi| Naito, Hiromichi| Yorifuji, Takashi| Zamami, Yoshito| Yamada, Akane| Koga, Tadashi| Imai, Toru| Sendo, Toshiaki| Nakao, Atsunori| Ichiba, Shingo| |
| Abstract | Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits. |
| Keywords | sedatives ECMO polyvinyl chloride pharmacokinetics pharmacodynamics |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 101 |
| End Page | 107 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015744 |
| JaLCDOI | 10.18926/AMO/56644 |
|---|---|
| FullText URL | 73_2_95.pdf |
| Author | Ercan, Sabriye| Başkurt, Ferdi| Başkurt, Zeliha| Çetin, Cem| |
| Abstract | The aim of this study was to examine effect of fatigue levels on functional mobility and balance in middle-aged obese females. The study included 98 healthy females aged 40-60 years with BMI ≥ 30 kg/m2. Self-perceived fatigue was evaluated with a self-administered questionnaire, the Checklist of Individual Strength in Turkish (CIS-T), on which 62.3% of the study subjects identified themselves as fatigued. The body weight and BMI values of fatigued subjects were found to be higher than those of the non-fatigue group (p<0.05). The reported exercise habits of the fatigue group were found to be significantly lower than their non-fatigued peers (p<0.05). The level of functional mobility (Timed Up and Go Test), static balance (One-Legged Stance Test with Eyes Open) and dynamic balance (Functional Reach Test and the 3-meter Timed Tandem Walk Test) were measured, and statistically significant differences were found between fatigue and non-fatigue groups on all of them (p<0.05). In addition, correlations were found between the sub-parameters of the CIS-T scale and the functional tests at |
| Keywords | fatigue obesity mobility balance woman |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-04 |
| Volume | volume73 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 95 |
| End Page | 100 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31015743 |
| Title Alternative | A survey of nurses’ and physicians’ safety awareness in CT/MRI examinations |
|---|---|
| FullText URL | 130_161.pdf |
| Author | Watanabe, Manae| Matsuura, Ryutaro| Namba, Shihoko| |
| Abstract | To perform computed tomography （CT）/magnetic resonance imaging （MRI） scans safely and reliably, adherence to a pre-scan checklist is crucial. However, physicians and nurses may differ in their recognition of the usefulness of this checklist. We conducted the present study to investigate possible differences between physicians’ and nurses’ awareness of CT/MRI scan safety in terms of their adherence to the pre-scan checklist. We prepared an independently developed self-administered 23-item questionnaire about attributes of subjects, CT/ MRI scan safety recognition and current situation for CT/MRI examinations. The survey was distributed to 468 participants who combined nurses and physicians at Okayama University Hospitalin Okayama, Japan. We analysis the responses of the 224 participants （117 nurses and 107 physicians）who returned the survey with on missing data （a 65.1% completion rate）. The overall safety recognition scores were significantly higher for the nurses than for the physicians （p＜0.001）. In addition, the physicians did not sufficiently know or implement the guidelines in the CT/MRI scan safety manual used at our hospital. Nurses and physicians demonstrated marked differences in their awareness and knowledge of safety regarding CT/MRI scans. Measures for improving safety recognition should thus be designed for individual healthcare occupations. |
| Keywords | CT/MRI検査（CT/MRI examinations） 安全認識（safety recognition） 職種の差異（difference between occupations） CT/MRI検査マニュアル（CT/MRI examinations manual） |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2018-12-03 |
| Volume | volume130 |
| Issue | issue3 |
| Start Page | 161 |
| End Page | 166 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.130.161 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2018 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.130.161 |
| NAID | 130007542844 |
| JaLCDOI | 10.18926/56591 |
|---|---|
| FullText URL | biess_3_071_084.pdf |
| Author | Kim, Dong Kwang| |
| Abstract | This paper sketches an undergraduate global studies program for a Japanese university. It first examines the context of the developing notions of global education and its current status. It then examines the appropriateness of the curriculum for global human resources development at Japanese universities, which passes widely as global education in Japan. It then shows why a new global studies program may be necessary by exposing the contradictions inherent in the programs of global human resources development taken as global education. The paper concludes by proposing a global studies curriculum to implement on the lower division level of a Japanese university. |
| Keywords | globalization global education global studies curriculum global human resources development Japanese education |
| Publication Title | Bulletin of Institute for Education and Student Services, Okayama University |
| Published Date | 2018-12-30 |
| Volume | volume3 |
| Start Page | 71 |
| End Page | 84 |
| ISSN | 2432-9665 |
| language | English |
| File Version | publisher |
| NAID | 120006600422 |
| JaLCDOI | 10.18926/AMO/56456 |
|---|---|
| FullText URL | 73_1_29.pdf |
| Author | Matsumoto, Atsushi| Nakamura, Takehiro| Shinomiya, Aya| Kawakita, Kenya| Kawanishi, Masahiko| Miyake, Keisuke| Kuroda, Yasuhiro| Keep, Richard F.| Tamiya, Takashi| |
| Abstract | Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4±15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2’-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS. |
| Keywords | biomarker histidine-rich glycoprotein predictor subarachnoid hemorrhage vasospasm |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 29 |
| End Page | 39 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820052 |
| JaLCDOI | 10.18926/AMO/56453 |
|---|---|
| FullText URL | 73_1_7.pdf |
| Author | Fukumori, Norio| Sonohata, Motoki| Kitajima, Masaru| Kawano, Shunsuke| Kurata, Tsuyoshi| Sakanishi, Yuta| Sugioka, Takashi| Mawatari, Masaaki| |
| Abstract | We evaluated the analgesic effects of multimodal pain control in which intravenous acetaminophen (IV APAP) was added to the standard protocol for Japanese patients who had undergone a total hip arthroplasty (THA). We performed a retrospective cohort study of 180 patients aged 66.4±10.5 years (30% male) who had undergone a THA (Oct. 2014 to Feb. 2015) at our hospital. The control patients were administered the standard analgesic protocol: flurbiprofen axetil as a continuous intravenous infusion and oral celecoxib (NAPAP; n=109). The patients in the new analgesic protocol group received IV APAP in addition to the standard analgesic protocol (APAP; n=71). The primary outcome was the maximum value of postoperative pain the patients reported on a numerical rating scale (NRS) during the first 24 h post-surgery. A univariate analysis and multivariate analyses adjusted for age, sex, the stage of hip osteoarthritis, preoperative pain, and surgical time showed that the maximum postoperative pain NRS scores during the first 24 h after surgery was significantly lower when the APAP protocol was used. The addition of IV APAP to the current standard multimodal analgesia protocol for Japanese patients who have undergone a THA may decrease the patients’ postoperative pain. |
| Keywords | intravenous acetaminophen postoperative pain total hip arthroplasty osteoarthritis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 14 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820049 |
| JaLCDOI | 10.18926/AMO/56452 |
|---|---|
| FullText URL | 73_1_1.pdf |
| Author | Morizane, Shin| |
| Abstract | Excessive protease activity is a characteristic abnormality that affects the epidermal barrier in patients with atopic dermatitis (AD). Kallikrein-related peptidases (KLKs) are excessively expressed in AD lesions, and it is suggested that the abnormal action of KLKs is involved in the skin barrier dysfunction in AD. In other words, overexpressed KLKs disrupt the normal barrier function, and due to that breakdown, external substances that can become antigens of AD easily invade the epidermis, resulting in dermatitis, coupled with the induction of Th2 cytokines. Further investigations are required to elucidate the role of KLKs in AD; this knowledge could contribute to the design of new therapeutic and prophylactic drugs for AD. |
| Keywords | atopic dermatitis kallikrein-related peptidases epidermal barrier dysfunction |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-02 |
| Volume | volume73 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30820048 |
| JaLCDOI | 10.18926/AMO/56380 |
|---|---|
| FullText URL | 72_6_605.pdf |
| Author | Mitsui, Yosuke| Sadahira, Takuya| Maruyama, Yuki| Wada, Koichiro| Tanimoto, Ryuta| Sugimoto, Morito| Araki, Motoo| Watanabe, Masami| Yanai, Hiroyuki| Watanabe, Toyohiko| Nasu, Yasutomo| |
| Abstract | Metastatic prostate cancer (PCa) cases that cannot be detected on repeat prostate biopsy are extremely rare. Our patient was a 51-year-old Japanese man diagnosed as metastatic PCa by histopathological examination of lesions obtained bone biopsy and lymph node dissection. The primary tumor was not detected after repeated prostate biopsy. Metastatic PCa was diagnosed based on immunohistochemical staining: PSA, AR, P504S, and NKX3.1 of bone and lymph node with metastasis. We speculate that the primary PCa was “burned-out,” demonstrating remote metastases with no apparent primary tumor in the prostate. Burned-out PCa may be difficult to diagnose and treat due to its rarity. |
| Keywords | prostate cancer metastasis unknown primary tumor repeat biopsy CRPC |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-12 |
| Volume | volume72 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 605 |
| End Page | 609 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30573917 |
| NAID | 120006545165 |
| JaLCDOI | 10.18926/AMO/56378 |
|---|---|
| FullText URL | 72_6_595.pdf |
| Author | Sugihara, Yuusaku| Harada, Keita| Kato, Ryo| Yamauchi, Kenji| Sakae, Hiroyuki| Kawano, Seiji| Hiraoka, Sakiko| Kawahara, Yoshiro| Otsuka, Fumio| Okada, Hiroyuki| |
| Abstract | The indications for peroral endoscopic myotomy (POEM) have been expanded to include diffuse esophageal spasm (DES). A 67-year-old Japanese man presented with a 4-year history of dysphagia. Endoscopy and upper gastrography revealed abnormal peristaltic movements involving interruption of normal peristalsis, and a diverticulum located at the 2 o’clock esophageal position. High-resolution manometry indicated DES. POEM with a long (15 cm) myotomy was performed for the abnormal contractions, which subsequently disappeared along with dysphagia improvement. Our results suggest that esophageal motility disorders accompanying a diverticulum may be eliminated by POEM without treating the diverticulum itself. We speculate that POEM ameliorates esophageal diverticulum by reducing internal esophageal pressure. |
| Keywords | diffuse esophageal spasm (DES) diverticulum, peroral endoscopic myotomy (POEM) high-resolution manometry (HRM) |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-12 |
| Volume | volume72 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 595 |
| End Page | 600 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30573915 |
| NAID | 120006545163 |
| FullText URL | PhysRevB_97_104511.pdf |
|---|---|
| Author | Kobayashi, Kaya| Ai, Yukio| Jeschke, Harald O.| Akimitsu, Jun| |
| Note | This is an article published by American Physical Society| |
| Published Date | 2018-03-26 |
| Publication Title | Physical Review B |
| Volume | volume97 |
| Publisher | American Physical Society |
| Start Page | 104511 |
| ISSN | 2469-9950 |
| NCID | AA11187113 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| DOI | 10.1103/PhysRevB.97.104511 |
| Web of Science KeyUT | 000428238600008 |
| Related Url | isVersionOf https://doi.org/10.1103/PhysRevB.97.104511 |
| JaLCDOI | 10.18926/AMO/56250 |
|---|---|
| FullText URL | 72_5_515.pdf |
| Author | Kanamitsu, Kiichiro| Chayama, Kousuke| Washio, Kana| Yoshida, Ryuichi| Umeda, Yuzo| Yagi, Takahito| Shimada, Akira| |
| Abstract | Hepatitis-associated aplastic anemia (HAAA) is an acquired bone marrow failure syndrome that develops after seronegative fulminant hepatitis. Abnormal cytotoxic T-cell activation with cytokine release is a possible pathophysiology. We present the case of a 16-month-old Japanese male who developed HAAA following living-donor liver transplantation for fulminant hepatitis. His aplastic anemia was successfully treated with immunosuppressive therapy. He had been administered tacrolimus for prophylaxis against hepatic allograft rejection. Ten years after the HAAA onset, the patient’s bone marrow was found to be slightly hypoplastic. Tacrolimus may be effective in controlling abnormal immune reactions that can cause recurrent impaired hematopoiesis. |
| Keywords | hepatitis-associated aplastic anemia impaired hematopoiesis liver transplantation immunosuppressive therapy abnormal immune reaction |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 515 |
| End Page | 518 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369609 |
| JaLCDOI | 10.18926/AMO/56247 |
|---|---|
| FullText URL | 72_5_493.pdf |
| Author | Okazaki, Yuki| Furumatsu, Takayuki| Masuda, Shin| Miyazawa, Shinichi| Kodama, Yuya| Kamatsuki, Yusuke| Hino, Tomohito| Okazaki, Yoshiki| Ozaki, Toshifumi| |
| Abstract | Medial meniscus (MM) posterior root tear (PRT) results in joint overloading and degenerative changes in the knee. MM root repair is recommended to prevent subsequent cartilage degeneration following MMPRT. Favorable clinical outcomes have been reported after transtibial pullout repair of MMPRT. However, it is unclear whether pullout repair can cause compositional change in the MM posterior segment. We examined this question in 14 patients who underwent MMPRT pullout repair. Magnetic resonance imaging examinations were performed preoperatively and 3 months postoperatively at 10° knee flexion. The region-of-interest was marked along the MM posterior segment edge. Intra-meniscal signal intensity (IMSI) was expressed as the signal intensity ratio of the repaired MM to the intact lateral meniscus, which was used as a control. MMPRT pullout repair reduced IMSI from 1 to 0.915±0.096 (range, 0.760-1.074) 3 months postoperatively (p=0.006, power=0.90). Meniscal degeneration causes high proton density-weighted imaging signal intensity of the meniscal body. In our study, MMPRT pullout repair reduced IMSI contrary to other tears. This technique may decrease the MM posterior segment signal intensity by restoring the hoop tension mechanism. Measuring IMSI may be useful to assess the effect of MMPRT pullout repair on meniscal healing. |
| Keywords | medial meniscus posterior root tear magnetic resonance imaging signal intensity arthroscopic surgery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 493 |
| End Page | 498 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369606 |
| JaLCDOI | 10.18926/AMO/56246 |
|---|---|
| FullText URL | 72_5_487.pdf |
| Author | Hamasaki, Ichiro| Shibata, Kiyo| Shimizu, Takehiro| Morisawa, Shin| Toshima, Shinji| Miyata, Manabu| Furuse, Takashi| Hasebe, Satoshi| Ohtsuki, Hiroshi| Morizane, Yuki| Shiraga, Fumio| |
| Abstract | We investigated variances in the stability and amount of postoperative exodrift among age groups of intermittent exotropia (XPT) patients who underwent unilateral lateral rectus muscle recession and medial rectus muscle resection. We analyzed the cases of 110 consecutive patients who underwent the surgery in 2004-2011, dividing the patients into groups by their age at surgery: <10, 10-19, and ≥20 years. We performed a regression analysis (dependent variable: postoperative exodrift (°); independent variable: number of days post-surgery) using the formula of curve lines. When the tangent line slope was = 0.01 (°/days) for each group, we defined the numbers of days until alignment became stable as the ‘stable days.’ We evaluated the between-group differences in the amount of exodrift calculated for the stable days. The coefficients and coefficients of determination for the fitting curves were: <10 year group: f(x)=12.2 (1−e−0.0183x) (r2=0.588, p<0.05); 10-19 year group: f(x)=10.0 (1−e−0.0178x) (r2=0.453, p<0.05); ≥20 year group: f(x)=3.40 (1−e−0.0382x) (r2=0.217, p<0.05). There were 389 , 388, and 153 stable days, and the estimated postoperative exodrift with long-term follow-up was 11.5±3.7°, 9.3±4.4°, and 4.1±3.6° for the < 10 year, 10-19 year, and ≥ 20 year groups, respectively (≥20 year vs. other 2 groups, p<0.05). Longer periods and more postoperative exodrift were associated with younger age at surgery. The postoperative evaluation was approx. ≥ 1 year post-surgery in patients aged < 20. These findings may contribute to evaluating XPT’s success rate and prognoses. |
| Keywords | intermittent exotropia postoperative exodrift recession resection procedure strabismus surgery |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 487 |
| End Page | 492 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369605 |
| JaLCDOI | 10.18926/AMO/56245 |
|---|---|
| FullText URL | 72_5_479.pdf |
| Author | Tanaka, Ken-ichi| Yagi, Takao| Nanba, Takeshi| Asanuma, Masato| |
| Abstract | We tried to clarify the applicability of a single prolonged stress (SPS) protocol as post-traumatic stress disorder (PTSD) model in mice. To investigate PTSD pathophysiology, we conducted hypothalamo-pituitary-adrenal (HPA) negative feedback testing at 1, 4, 8 and 12 weeks after the SPS by administrating a dexamethasone (DEX) suppression test. The SPS induced over-suppression of the HPA system by DEX treatment at 8 and 12 weeks. To investigate PTSD-like behavioral characteristics, we subjected mice to testing in a light/dark box (to assess anxiety), a Y-maze (working memory), a cliff avoidance (visual cognition), and an open field (locomotor activity) at 1, 4, 8 and 12 weeks after the SPS. In the light/dark box test, the SPS-applied mice spent significantly less time in the light box at 8 or 12 weeks. In the cliff avoidance test, the SPS-applied mice spent significantly less time in the open area at 1 week. However, in both the Y-maze test and the open field test, SPS-applied mice tended toward slight decreases in a time-dependent manner until 12 weeks. Therefore, SPS-applied mice may thus be useful for assessing characteristics relevant to PTSD that coincide with changes in the HPA axis. |
| Keywords | PTSD single prolonged stress corticosterone mouse |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 479 |
| End Page | 485 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369604 |
| JaLCDOI | 10.18926/AMO/56242 |
|---|---|
| FullText URL | 72_5_447.pdf |
| Author | Oka, Kosuke| Hanayama, Yoshihisa| Sato, Asuka| Omura, Daisuke| Yasuda, Miho| Hasegawa, Ko| Obika, Mikako| Otsuka, Fumio| |
| Abstract | We retrospectively analyzed the cases of 148 febrile patients whose body temperature (BT) was ≥ 37.5°C at our hospital. We categorized them into seven groups; those with bacterial and viral infection, nonspecific inflammation, neoplasm, connective tissue disease (CTD), drug-induced disease, and unidentified causes. Our analysis revealed that the patient’s BT at the 1st visit (BT-1st visit) and highest BT during the febrile period (BT-max) differed significantly among all categories except neoplasm. The greatest difference between BT-1st visit and BT-max was highest in the CTD group (1.5°C). Positive correlations of heart rate and C-reactive protein (CRP) level with BT-max and a negative correlation between serum sodium level with BT-max were uncovered. The serum thyroid-stimulating hormone (TSH) level and the ratio of TSH/free thyroxine were negatively correlated with BT-max, especially in the viral infection group, suggesting the existence of occult thyrotoxicosis in accord with a febrile condition, possibly leading to febrile tachycardia. A febrile gap between BT-1st visit and BT-max (except in the neoplasm group) was shown, in which BT-max was correlated with thyroid function. Clinicians should recognize the fluctuation of BT when diagnosing febrile patients, and tachycardia in such febrile patients may be, at least in part, associated with subclinical thyroid dysfunction. |
| Keywords | body temperature C-reactive protein fever of unknown origin tachycardia thyroid dysfunction |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-10 |
| Volume | volume72 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 447 |
| End Page | 456 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30369601 |
| FullText URL | Gerodontology_34_1_129.pdf |
|---|---|
| Author | Kobayashi, Naoki| Soga, Yoshihiko| Maekawa, Kyoko| Kanda, Yuko| Kobayashi, Eiko| Inoue, Hisako| Kanao, Ayana| Himuro, Yumiko| Fujiwara, Yumi| |
| Keywords | dementia hospital care mouth risk management |
| Note | This is an Accepted Manuscript of an article published by John Wiley| |
| Published Date | 2017-03 |
| Publication Title | Gerodontology |
| Volume | volume34 |
| Issue | issue1 |
| Publisher | John Wiley |
| Start Page | 129 |
| End Page | 134 |
| ISSN | 0734-0664 |
| NCID | AA10450927 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 27207609 |
| DOI | 10.1111/ger.12235 |
| Web of Science KeyUT | 000394951200016 |
| Related Url | isVersionOf https://doi.org/10.1111/ger.12235 |
