result 47987 件
| JaLCDOI | 10.18926/AMO/54982 |
|---|---|
| FullText URL | 71_2_135.pdf |
| Author | Mori, Akihiro| Watanabe, Masami| Sadahira, Takuya| Kobayashi, Yasuyuki| Ariyoshi, Yuichi| Ueki, Hideo| Wada, Koichiro| Ochiai, Kazuhiko| Li, Shun-Ai| Nasu, Yasutomo| |
| Abstract | The cluster of differentiation 147 (CD147), also known as EMMPRIN, is a key molecule that promotes cancer progression. We previously developed an adenoviral vector encoding a tumor suppressor REIC/Dkk-3 gene (Ad-REIC) for cancer gene therapy. The therapeutic effects are based on suppressing the growth of cancer cells, but, the underlying molecular mechanism has not been fully clarified. To elucidate this mechanism, we investigated the effects of Ad-REIC on the expression of CD147 in LNCaP prostate cancer cells. Western blotting revealed that the expression of CD147 was significantly suppressed by Ad-REIC. Ad-REIC also suppressed the cell growth of LNCaP cells. Since other researchers have demonstrated that phosphorylated mitogen-activated protein kinases (MAPKs) and c-Myc protein positively regulate the expression of CD147, we investigated the correlation between the CD147 level and the activation of MAPK and c-Myc expression. Unexpectedly, no positive correlation was observed between CD147 and its possible regulators, suggesting that another signaling pathway was involved in the downregulation of CD147. This is the first study to show the downregulation of CD147 by Ad-REIC in prostate cancer cells. At least some of the therapeutic effects of Ad-REIC may be due to the downregulation of the cancer-progression factor, CD147. |
| Keywords | prostate cancer REIC/Dkk-3 CD147 cell growth p38 MAP kinase |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 135 |
| End Page | 142 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420895 |
| JaLCDOI | 10.18926/AMO/54981 |
|---|---|
| FullText URL | 71_2_127.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi| |
| Abstract | Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified. |
| Keywords | esophageal cancer radiation therapy high-risk patient |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 127 |
| End Page | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420894 |
| JaLCDOI | 10.18926/AMO/54980 |
|---|---|
| FullText URL | 71_2_119.pdf |
| Author | Oda, Yoshiaki| Takigawa, Tomoyuki| Sugimoto, Yoshihisa| Tanaka, Masato| Akazawa, Hirofumi| Ozaki, Toshifumi| |
| Abstract | Patients with cerebral palsy (CP) frequently present with scoliosis; however, the pattern of curve progression is difficult to predict. We aimed to clarify the natural course of the progression of scoliosis and to identify scoliosis predictors. This was a retrospective, single-center, observational study. Total of 92 CP patients from Asahikawasou Ryouiku Iryou Center in Okayama, Japan were retrospectively analyzed. Cobb angle, presence of hip dislocation and pelvic obliquity, and Gross Motor Function Classification System (GMFCS) were investigated. Severe CP was defined as GMFCS level IV or V. The mean observation period was 10.7 years. Thirtyfour severe CP patients presented with scoliosis and were divided into 3 groups based on their clinical courses: severe, moderate and mild. The mean Cobb angles at the final follow-up were 129°, 53°, and 13° in the severe, moderate, and mild groups, respectively. The average progressions from 18 to 25 years were 2.7°/year, 0.7°/year, and 0.1°/year in the severe, moderate, and mild curve groups, respectively. We observed the natural course of scoliosis and identified 3 courses based on the Cobb angle at 15 and 18 years of age. This method of classification may help clinicians predict the patients’ disease progression. |
| Keywords | severe cerebral palsy scoliosis natural course Cobb angle progression |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 119 |
| End Page | 126 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420893 |
| JaLCDOI | 10.18926/AMO/54979 |
|---|---|
| FullText URL | 71_2_113.pdf |
| Author | Morikawa Tatsuya| Okabayashi Takehiro| Shima, Yasuo| Sumiyoshi, Tatsuaki| Kozuki, Akihito| Saisaka, Yuichi| Tokumaru, Teppei| Sui, Kenta| Iwata, Jun| Matsumoto, Manabu| Morita, Sojiro| Nishioka, Yutaka| |
| Abstract | Some clinicians have proposed a relationship between gallbladder (GB) cancer and adenomyomatosis (ADM) of the gallbladder, although the latter condition is not considered to have malignant potential. We retrospectively reviewed the surgical pathology database of patients who underwent resection for ADM of the gallbladder at our institution from March 2005 to May 2015. In total, 624 patients underwent surgical resection of the gallbladder with Rokitansky-Aschoff sinuses. Of these cases, 93 were pathologically diagnosed with ADM of the gallbladder, with 44 (47.3%) classified macroscopically as fundal-type ADM, 26 (28.0%) as segmental type, and 23 (24.7%) as diffuse-type ADM. In 3 of the 93 (3.2%) resected specimens, early-stage GB carcinoma was detected, although preoperative imaging did not suggest a malignant neoplasm of the gallbladder in any of these patients. GB cancer subsequently developed in the mucosa of the fundal compartment distal to the annular stricture of the segmental-type ADM in 2 of these patients and against the background of the fundal-type ADM in 1 patient. This study revealed the difficulty of early diagnosis of primary GB cancer in the setting of concurrent ADM, and clinicians should be aware of this frequent coexistence. |
| Keywords | adenomyomatosis gallbladder carcinoma Rokitansky-Aschoff sinuses surgery carcinogenesis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 113 |
| End Page | 118 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420892 |
| JaLCDOI | 10.18926/AMO/54978 |
|---|---|
| FullText URL | 71_2_105.pdf |
| Author | Shinya, Takayoshi| Tanaka, Takashi| Soh, Junichi| Matsushita, Toshi| Sato, Shuhei| Toyooka, Shinichi| Yoshino, Tadashi| Miyoshi, Shinichiro| Kanazawa, Susumu| |
| Abstract | We retrospectively assessed the dual-time-point (DTP) F-18 FDG PET/CT findings of thymic epithelial neoplasms (TENs) and investigated the diagnostic capacity of PET/CT compared to that of CT for predicting carcinoma. We calculated the ratio of the standardized uptake value of the tumor and that of the aortic arch (T/M ratio) for both the 90-min early scan and the 2-h delayed scan in 56 TEN patients. We used a multivariate logistic regression (MLR) analysis to estimate the CT features of carcinoma. We compared the diagnostic capacities of PET/CT and chest CT using receiver operating characteristic (ROC) analyses. The ROC curve revealed that the appropriate cut-off T/M ratio value for the highest accuracy was 2.39 with 75.0% accuracy. The area under the curve (AUC) was 0.855. The statistical analyses for DTP scans of 35 TEN patients demonstrated 74.3% accuracy and 0.838 AUC for the early scan versus 82.9% and 0.825 for the delayed scan. The MLR analysis indicated that mediastinal fat infiltration was a predictor of carcinoma. The ROC curve obtained for the model yielded an AUC of 0.853. Delayed scanning could improve the diagnostic capacity for carcinoma. The T/M ratio and mediastinal fat infiltration are predictive of carcinoma with moderate diagnostic accuracy. |
| Keywords | thymic epithelial neoplasm thymic carcinoma thymoma dual-time-point PET/CT chest CT |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 105 |
| End Page | 112 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420891 |
| JaLCDOI | 10.18926/AMO/54977 |
|---|---|
| FullText URL | 71_2_97.pdf |
| Author | Iwamuro, Masaya| Kondo, Eisei| Tanaka, Takehiro| Hagiya, Hideharu| Kawano, Seiji| Kawahara, Yoshiro| Otsuka, Fumio| Okada, Hiroyuki| |
| Abstract | We retrospectively analyzed the cases of 14 patients (9 women, 5 men, mean age: 51.6 years) with cytomegalovirus (CMV) involvement in the esophagus, stomach, and/or duodenum diagnosed at a single center, to determine their endoscopic features and clinical backgrounds. Thirteen patients (92.9%) had hematologic disease; the other had rheumatoid arthritis. Of the former, 12 patients underwent allogeneic hematopoietic stem cell transplantation, and 9 of these patients had graft-versus-host disease (GVHD) before undergoing esophagogastroduodenoscopy (EGD). All 14 patients had been taking one or more immunosuppressive agents including cyclosporine (n=10), corticosteroids (n=9), mycophenolic acid (n=6), tacrolimus (n=3), and methotrexate (n=1). Tests for CMV antigenemia were positive in 11 patients (78.6%). EGD examinations revealed esophageal (n=3), gastric (n=9), and duodenal involvement (n=6). Macroscopically, esophageal lesions by CMV infection presented as redness (n=1), erosions (n=1), and ulcers (n=1). Gastric lesions manifested as redness (n=7), erosions (n=3), exfoliated mucosa (n=2), and verrucous erosions (n=1). Mucosal appearances in the duodenum varied: redness (n=2), ulcers (n=2), multiple erosions (n=2), single erosion (n=1), edema (n=1). CMV was detected even in the intact duodenal mucosa (n=1). In conclusion, physicians must recall the relevance of CMV infection when any mucosal alterations exist in the upper gastrointestinal tract of immunosuppressed patients. |
| Keywords | cytomegalovirus duodenum esophagogastroduodenoscopy esophagus stomach |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 97 |
| End Page | 104 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420890 |
| JaLCDOI | 10.18926/AMO/54976 |
|---|---|
| FullText URL | 71_2_91.pdf |
| Author | Ogawa, Nanako| Sato, Shuhei| Ida, Kentaro| Kato, Katsuya| Ariyoshi, Yuichi| Wada, Koichiro| Nasu, Yasutomo| Kanazawa, Susumu| |
| Abstract | The aim of this study was to investigate the utility of single-source dual-energy computed tomography (SS-DECT) composition analysis in characterizing different types of urinary stones and differentiating them from phleboliths. This study included 29 patients with urinary stones who were scheduled for surgery. All patients were scanned, first using single-energy computed tomography acquisition and then DECT acquisition on SS-DECT. Dual-energy data were archived to a Gemstone spectral imaging (GSI) viewer (GE Healthcare, Milwaukee, WI, USA). Hounsfield units (HU) and effective atomic numbers (Zeff) were estimated using the GSI viewer. The results of dual-energy analysis were compared with the biochemical constitution of the stones. The chemical analysis determined that the stones included 32 calcium-based, 6 cystine and 1 struvite stone. Both HU and Zeff values were helpful in differentiating calcium-based stones from cystine and struvite stones and phleboliths. The Zeff values of phleboliths were significantly higher than those for struvite and cystine stones, whereas it was difficult to distinguish phleboliths from struvite and cystine stones using the HU values. Composition analysis using SS-DECT is helpful for distinguishing urinary stone types and discriminating phleboliths from urinary stones. Zeff values may be more useful than HU values for differentiating urinary stones from phleboliths. |
| Keywords | single-source dual-energy computed tomography effective atomic number urinary stone phlebolith |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 91 |
| End Page | 96 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420889 |
| Author | 岡山大学大学院社会文化科学研究科| |
|---|---|
| Published Date | 2017-03-24 |
| Publication Title | Journal of Humanities and Social Sciences |
| Volume | volume43 |
| Content Type | Others |
| Author | 岡山大学大学院社会文化科学研究科| |
|---|---|
| Published Date | 2017-03-24 |
| Publication Title | Journal of Humanities and Social Sciences |
| Volume | volume43 |
| Content Type | Others |
| JaLCDOI | 10.18926/54972 |
|---|---|
| Title Alternative | "Bianhua Qizhi" in Zhu Xi Philosophy |
| FullText URL | hss_043_(001)_(021).pdf |
| Author | Sun, Luyi| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | (1) |
| End Page | (21) |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| JaLCDOI | 10.18926/54971 |
|---|---|
| Title Alternative | Analysis of the Application in Judiciary Practice of Article 4 of the "Law of the People's Republic of China on the Laws Applicable to Foreign-related Civil Relations" |
| FullText URL | hss_043_179_192.pdf |
| Author | Zhang, Guangjie| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 179 |
| End Page | 192 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026992 |
| JaLCDOI | 10.18926/54970 |
|---|---|
| Title Alternative | Die Reichweite der wesenslogischen "Wechselwirkung" in Hegels Wissenschaft der Logik (2) |
| FullText URL | hss_043_163_178.pdf |
| Author | Takeshima, Naohito| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 163 |
| End Page | 178 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026991 |
| JaLCDOI | 10.18926/54969 |
|---|---|
| Title Alternative | The Authority of Public Schools and Students’ Freedom of Speech and Expression: Analysis of U.S. Supreme Court Precedents after the Tinker Verdict |
| FullText URL | hss_043_141_162.pdf |
| Author | Matano, Eiji| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 141 |
| End Page | 162 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026990 |
| JaLCDOI | 10.18926/54968 |
|---|---|
| Title Alternative | Über den Begriff des Existenzgründers in Deutschland |
| FullText URL | hss_043_119_140.pdf |
| Author | Chinen, Akiko| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 119 |
| End Page | 140 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026989 |
| JaLCDOI | 10.18926/54967 |
|---|---|
| Title Alternative | Reconsidering "Stative" as a Semantic Category and "Stative Verbs" in Japanese |
| FullText URL | hss_043_101_118.pdf |
| Author | Wu, Yang| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 101 |
| End Page | 118 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026988 |
| JaLCDOI | 10.18926/54966 |
|---|---|
| Title Alternative | Birth of the United Nations Partition Resolution on Palestine and Loss of the Unitary State Plan : Focusing on the Discussion in the Ad Hoc Committee |
| FullText URL | hss_043_081_099.pdf |
| Author | Sato, Hirokazu| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 81 |
| End Page | 100 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026987 |
| JaLCDOI | 10.18926/54965 |
|---|---|
| FullText URL | hss_043_061_080.pdf |
| Author | Teraoka, Takanori| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 61 |
| End Page | 80 |
| ISSN | 1881-1671 |
| language | German |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026986 |
| JaLCDOI | 10.18926/54964 |
|---|---|
| Title Alternative | The Formation and Problem of a Mass Consumption Society in China |
| FullText URL | hss_043_041_060.pdf |
| Author | Teng, Jian| Fang, Wenhui| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 41 |
| End Page | 60 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026985 |
| JaLCDOI | 10.18926/54963 |
|---|---|
| Title Alternative | Gerontology in Modern Japan : A study on TERASAWA Izuo's ideas on gerontology |
| FullText URL | hss_043_021_040.pdf |
| Author | Motomura, Masafumi| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 21 |
| End Page | 40 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026984 |
| JaLCDOI | 10.18926/54962 |
|---|---|
| Title Alternative | Outline of the Taierzhuang Strategy |
| FullText URL | hss_043_001_020.pdf |
| Author | Jiang, Keshi| |
| Publication Title | Journal of Humanities and Social Sciences |
| Published Date | 2017-03-24 |
| Volume | volume43 |
| Start Page | 1 |
| End Page | 20 |
| ISSN | 1881-1671 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 120006026983 |
