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ID 31537
JaLCDOI
FullText URL
Author
Neya, Toshiaki
Itano, Noriaki
Nakayama, Sosogu
Abstract

Effects of noradrenaline (NA) on the isolated rectal circular muscle of the cats were studied in comparison with the effects on the internal anal sphincter (IAS). NA (10(-8)-10(-7) g/ml) caused tonic contraction in four of 15 strips of the rectum taken from 15 animals, and in all 15 strips of the IAS. Phenylephrine also induced rectal and IAS contraction. Rectal contraction induced by NA was resistant to phentolamine, yohimbine, propranolol, hexamethonium and tetrodotoxin, but blocked by atropine. IAS contraction induced by NA was resistant to propranolol, atropine, hexamethonium and tetrodotoxin, but blocked by phentolamine and yohimbine. It is suggested that an atropine-sensitive excitatory adrenergic mechanism other than the excitatory alpha-adrenergic mechanism exists in the rectal circular muscle.

Keywords
gastrointestinal motility
rectum
noradrenaline
adrenergic receptors
muscarinic receptor.
Amo Type
Article
Publication Title
Acta Medica Okayama
Published Date
1985-02
Volume
volume39
Issue
issue1
Publisher
Okayama University Medical School
Start Page
53
End Page
57
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
English
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT