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Author
Sato, Daisuke Department of Nephrology, Juntendo University Faculty of Medicine
Gohda, Tomohito Department of Nephrology, Juntendo University Faculty of Medicine
Kihara, Masao Department of Nephrology, Juntendo University Faculty of Medicine
Kanaguchi, Yasuhiko Department of Nephrology, Juntendo University Faculty of Medicine
Kobayashi, Takashi Department of Nephrology, Juntendo University Faculty of Medicine
Mano, Satoshi Department of Nephrology, Juntendo University Faculty of Medicine
Sasaki, Yu Department of Nephrology, Juntendo University Faculty of Medicine
Nohara, Nao Department of Nephrology, Juntendo University Faculty of Medicine
Murakoshi, Maki Department of Nephrology, Juntendo University Faculty of Medicine
Nakata, Junichiro Department of Nephrology, Juntendo University Faculty of Medicine
Suzuki, Hitoshi Department of Nephrology, Juntendo University Faculty of Medicine
Ueda, Seiji Department of Nephrology, Juntendo University Faculty of Medicine
Horikoshi, Satoshi Department of Nephrology, Juntendo University Faculty of Medicine
Suzuki, Yusuke Department of Nephrology, Juntendo University Faculty of Medicine
Abstract
Some patients with chronic kidney disease (CKD) receiving hemodialysis develop erythropoietin-resistant anemia, possibly due to zinc deficiency. The frequency of zinc deficiency in CKD (stages 1-5 and 5D) and CKD improvement via zinc supplementation are not completely verified. Here 500 CKD patients (Stage 1/2, n=100; Stage 3, n=100; Stage 4, n=100, Stage n=5, 100; Stage 5D, n=100) will be recruited to determine the frequency of serum zinc deficiency at each CKD stage. Patients with serum zinc concentrations <80 μg/dL will be treated with zinc acetate dihydrate (NobelzinR) to evaluate its effects on hypozincemia, taste disturbances, and anemia.
Keywords
zinc acetate dihydrate
anemia
chronic kidney disease
Amo Type
Clinical Study Protocol
Publication Title
Acta Medica Okayama
Published Date
2018-10
Volume
volume72
Issue
issue5
Publisher
Okayama University Medical School
Start Page
535
End Page
538
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
English
Copyright Holders
CopyrightⒸ 2018 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID