result 35591 件
| JaLCDOI | 10.18926/bgeou/52179 |
|---|---|
| Title Alternative | The Changes in Physics Education at the Fachoberschule（ Vocationally-oriented Upper Secondary School） in Germany － Comparative Study between the Old and the New Textbook － |
| FullText URL | bgeou_155_079_089.pdf |
| Author | Tanaka, Kenji| Tanaka, Keita| |
| Abstract | ドイツの職業教育諸学校の一つ，専門上級学校に焦点を当て，新旧物理教科書の比較考察に基づき，物理教育の変遷を明らかにしてきた。技師学校，高等専門学校の専門大学への昇格とともに，準備校として，職業上構学校などから創られてきた40年程度の伝統を有する専門上級学校用の新旧物理教科書において，物理教育の概念・構造が大きく異なっている。旧では，力ではじまり電気などを経て原子でおわるが，新では力と電気だけという範囲に違いがあること，重複（共通）している索引の割合は，旧では５％程度，新では30％程度であることなどは，学校の創生期（多様な生徒）からの隔りなどを経てきた，独自性の確立であり，また，単位系移行からの完了などが背景といえる。 |
| Keywords | ドイツ 専門上級学校 物理教育 変遷 教科書比較 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-02-25 |
| Volume | volume155 |
| Start Page | 79 |
| End Page | 89 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005394604 |
| JaLCDOI | 10.18926/bgeou/52178 |
|---|---|
| Title Alternative | Physics Education at the Vocational Education Schools in Bavaria, a State of Germany |
| FullText URL | bgeou_155_067_078.pdf |
| Author | Tanaka, Kenji| Tanaka, Keita| |
| Abstract | ドイツ・バイエルン邦の職業教育諸学校に焦点を当て, いわば学校教育法，同施行規則，学習指導要領などを手がかりにし, 普通教育諸学校との対比などから物理教育を整理してきた。学校は，中等教育段階が分岐するフォーク型の普通教育諸学校と中等教育段階に属する多様な職業教育諸学校などに，峻別されている。中等教育段階に属する普通教育諸学校には教科物理があるが，職業教育諸学校ではなかったり，多くの授業時間数が配当されているなど多様であり，教科物理がある職業教育諸学校の学校種・科などでも，熱，原子，光，天文などを扱わないという偏りがあった。 |
| Keywords | ドイツ バイエルン邦 職業教育諸学校 物理教育 学習指導要領 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-02-25 |
| Volume | volume155 |
| Start Page | 67 |
| End Page | 78 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005394603 |
| JaLCDOI | 10.18926/bgeou/52177 |
|---|---|
| Title Alternative | The Discourse of Darwinism in Felix Holt, the Radical |
| FullText URL | bgeou_155_057_066.pdf |
| Author | Fukunaga, Shintetsu| |
| Abstract | The present paper focuses attention on an influence of Darwinism as seen in the discourse of Felix Holt, the Radical. True George Eliot’s early and middle-period novels show signs of a vision of Natural History with its emphasis on scientific observation of the natural world. But as the impact of The Origin of Species (1859) sent a shock wave among the intellectual circle across Europe, she became growingly aware of its farreaching implications. Inevitably Eliot’s novelistic discourse has become permeated with the evolutionary outlook and terminology. Felix Holt marks a turning point in the sense that it is structurally conceived by the method of experimental science, and is clothed in its phraseology. We see how the writer’s moral and religious vision finds itself subtly reconciled with scientific world view. |
| Keywords | 進化 有機的生命 ネメシス 罪 仮説・検証 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-02-25 |
| Volume | volume155 |
| Start Page | 57 |
| End Page | 66 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005394602 |
| JaLCDOI | 10.18926/bgeou/52175 |
|---|---|
| Title Alternative | A Study of the Post-War History of Teaching Writing in Japan |
| FullText URL | bgeou_155_041_047.pdf |
| Author | Sugahara, Minoru| |
| Keywords | 戦後 作文 綴り方 第１回作文教育全国協議会 中津川大会 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-02-25 |
| Volume | volume155 |
| Start Page | 41 |
| End Page | 47 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005394600 |
| JaLCDOI | 10.18926/bgeou/52174 |
|---|---|
| Title Alternative | Sounds in Jen Hadfield’s Nigh-No-Place |
| FullText URL | bgeou_155_035_040.pdf |
| Author | Okada, Kazuya| |
| Abstract | 音が先まわりしている言葉―。ここで，1978年生まれのスコットランド詩人の詩集を考 察する。Jen Hadfield のT. S. Eliot Prize を受賞した詩集である。 Jen Hadfield は，2003年にも大きな別の文学賞，Eric Gregory Award を受賞しているが， ここでは，より強烈な実験的詩 コレクション 集であるNigh-No-Place（2008年出版）を扱う。 活字・音声・韻律・舌・発声などのダイナミズムのうちに詩を考察することは， ponepoetics（あるいはphonepoetics）の試みであり，「音読詩学（あるいは朗読詩学）」／ 「朗読詩論」の展開と挑みとなる。 |
| Keywords | Jen Hadfield synesthesia of sound/word after-image/after-sound rhyme |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-02-25 |
| Volume | volume155 |
| Start Page | 35 |
| End Page | 40 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005394599 |
| JaLCDOI | 10.18926/bgeou/52172 |
|---|---|
| Title Alternative | Utilizing Video Self-Modeling and Video Hero Modeling to Increase Task Engagement of an Elementary-Aged Student with Autism Spectrum Disorder. |
| FullText URL | bgeou_155_013_022.pdf |
| Author | Ohtaka, Yoshihisa| Takahashi, Ayaka| Takeuchi, Ai| Watanabe, Kentaro| Hamada, Toshiko| |
| Abstract | 本研究では，集中して着替えに取り組むことが難しい一人の知的障害のある自閉症スペクトラム障害児に対して，３種類のビデオモデリング技法を順次適用し，どの技法がもっとも着替え従事率の上昇をもたらすかを検討した。用いられた技法は，①本人が着替えに取り組 むビデオを着替えに先立ち視聴させる技法，②本人が着替えの競争でヒーローに勝つビデオを着替えに先立ち視聴させる技法，③ヒーローが着替えに取り組むビデオを着替えの最中に視聴させる技法の３つであった。ABACADA デザインを用いてこれら３つの介入効果を比 較した結果，③の技法のみに効果が確認された。 |
| Keywords | 自閉症スペクトラム障害 日常生活の指導 ビデオセルフモデリング ビデオヒーローモデリング |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-02-25 |
| Volume | volume155 |
| Start Page | 13 |
| End Page | 22 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005394597 |
| JaLCDOI | 10.18926/ESR/52167 |
|---|---|
| Title Alternative | Preliminary analyses on the climatological features of precipitation characteristics and large-scale atmospheric fields on the heavy rainfall days in the eastern part of Japan during the mature stage of the Baiu season |
| FullText URL | esr_020_1_025_034.pdf |
| Author | Matsumoto, Kengo| Kato, Kuranoshin| Otani, Kazuo| |
| Abstract | Rainfall characteristics and large-scale atmospheric fields on the “heavy rainfall days” (with more than 50 mm/day) in the mature stage of the Baiu season (16 June ~ 15 July) at Tokyo in the eastern part of the Japan Islands were examined, based on the daily and the hourly precipitation data from 1971 to 2010. Appearance frequency of the “heavy rainfall days” at Tokyo attained only about 1/3 of that at Nagasaki in the western Japan. Furthermore, it is noted that about half of the “heavy rainfall days” at Tokyo were related to the typhoon. In detail, about half of the typhoon cases were associated with the direct approach of a typhoon (referred to as Pattern A, hereafter), the other half corresponded to the situation when the Baiu front also stagnated around Kanto District with a typhoon to the southwest of Kanto (Pattern B). Although the contribution of the intense rainfall with more than 10 mm/h to the total precipitation was large in Pattern A, that with less than 10 mm/h was dominant in Patterns B and C (Pattern C: meso-α-scale cyclone on the Baiu front approaching to the Kanto District). It is noted that about half of the “heavy rainfall days” corresponded to these pattern. In other words, unlike the localized torrential rain in western Japan, the “heavy rainfall days” due to the duration of “not-so-intense-rain” appeared rather frequently in the eastern part of Japan even in the Baiu season. In both Patterns B and C, relatively strong low-level southerly wind associated with the disturbance (a typhoon or a meso-α-scale cyclone) invades into the baroclinic zone in the basic field sustained as the sowthwestern edge of the cool Okhotsk air mass. It is interesting that the “heavy rainfall days” there due to the contribution of the persistent “not-so-intense-rain” occur just in such situation. |
| Keywords | rainfall characteristics in eastern Japan heavy rainfall in eastern Japan in Baiu season rainfall climatology |
| Publication Title | Okayama University Earth Science Report |
| Published Date | 2013-12-27 |
| Volume | volume20 |
| Issue | issue1 |
| Start Page | 25 |
| End Page | 34 |
| ISSN | 1340-7414 |
| language | Japanese |
| Copyright Holders | © 2013 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| File Version | publisher |
| NAID | 120005394595 |
| JaLCDOI | 10.18926/ESR/52166 |
|---|---|
| Title Alternative | A case study on the rainfall distribution over the Japan Islands associated with the approach of Ty0423 in late October (Comparison with that for Ty0418) |
| FullText URL | esr_020_1_013_024_rev.pdf |
| Author | Satake, Ai| Kato, Kuranoshin| Mori, Yoshinori| Goda, Yasuhiro| Ikeda, Shoichiro| Tsukamoto, Osamu| |
| Abstract | Rainfall distribution in the Japan Islands associated with the approach of Typhoon No.23 around 20 October 2004 (referred to Ty0423, hereafter) showed considerably different features from those in late summer of this year. The present study examined the detailed rainfall features around the Japan Islands brought by Ty0423 and the atmospheric processes based on the operational observation data by the Japan Meteorological Agency (JMA), comparing with those in association with Ty0418 around 7 September 2004. During the stage when Ty0423 was approaching or landing on the western part of the Japan Islands, the areal mean precipitation from Kyushu to Kanto District attained much larger than that for Ty0418, with wider extension of the area with the large amount of precipitation. It is interesting that, although the intense rainfall was observed only at the upstream side of the mountain range from Kyushu to Honshu District for Ty0418 except for the area near its center, strong rainfall with 10~30 mm/h persisted in wider regions from the western to the eastern part of the Japan Islands, resulting in the considerably large total rainfall for Ty0423. As for the case for Ty0423, the surface front with stable frontal surface was located just to the east of the Ty0423 center just before its landing at the Japan Islands. Thus, the huge moisture inflow mainly in the eastern region from the typhoon center seems to be redistributed widely over the Japan Islands area associated with the large-scale convergence around the stable frontal surface. In late October, the colder air associated with the high pressure system in the eastern Siberia can cover the northern part of the Japan Sea area as the seasonal march. Such basic field might be favorable for sustaining the synoptic-scale front just around the southern coast of the Japan Islands, even when the strong southerly wind invades associated with the typhoon approach there. |
| Keywords | Ty0423 Ty0418 rainfall in Japan associated with a typhoon in mid-autumn effects of a typhoon on the synoptic climatology in Japan in October |
| Publication Title | Okayama University Earth Science Report |
| Published Date | 2013-12-27 |
| Volume | volume20 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 24 |
| ISSN | 1340-7414 |
| language | Japanese |
| Copyright Holders | © 2013 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| File Version | publisher |
| NAID | 120005394594 |
| JaLCDOI | 10.18926/ESR/52165 |
|---|---|
| Title Alternative | On Periploma mitsuganoense Araki (Bivalvia: Mollusca) from the Miocene Bihoku Group in Niimi City, Okayama Prefecture, southwest Japan ―with special reference to it’s paleogeographic significance― |
| FullText URL | esr_020_1_007_011.pdf |
| Author | Taguchci, Eiji| Kishimoto, Shingo| Suzuki, Shigeyuki| |
| Abstract | In this paper, we deal with re-description of Periploma mitsuganoense Araki and it’s morphological variation and significance of the molluscan fauna of it from the Miocene Bihoku Group in Niimi City, Okayama Prefecture, Southwest Japan. Moreover, the paleogeographic significance of this species is analyzed. The obtained results are summarized as follows: 1. The morphological variation of Periploma mitsuganoense Araki has a wide range on the basis of the analysis of the morphological outline. 2. The occurrence of P. mitsuganoense Araki from the Pectinid fauna is the first record in the West Setouchi Geological Province. 3. It is presumable that P. mitsuganoense Araki is an endemic species in the First Setouchi Geological Province from a view point of it’s spatial distribution. |
| Keywords | Periploma mitsuganoense Araki Mollusca Miocene Bihoku Group morphological variation paleogeographic significance |
| Publication Title | Okayama University Earth Science Report |
| Published Date | 2013-12-27 |
| Volume | volume20 |
| Issue | issue1 |
| Start Page | 7 |
| End Page | 11 |
| ISSN | 1340-7414 |
| language | Japanese |
| Copyright Holders | © 2013 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| File Version | publisher |
| NAID | 120005394593 |
| JaLCDOI | 10.18926/ESR/52164 |
|---|---|
| Title Alternative | Debris avalanche occurred in Kitamura area, Kurashiki City, Okayama Prefecture |
| FullText URL | esr_020_1_001_006.pdf |
| Author | Kimura, Yuki| Suzuki, Shigeyuki| |
| Abstract | The debris avalanche occurred in Kitamura area, Kurashiki City, Okayama Prefecture caused by the hard rain of Typhoon 12 of September, 2011. Furthermore, 11 small landslides occurred in the study area. In this area, the altitude of mountainous are not so high (150m to 250m) and the amount of precipitation which producted the debris avalanche was not very serious quantity with 230mm. However the debris avalanche occurred. One private house collapsed, and the first floor part of the Kitamura Elementary School was buried due to the debris flow. The purpose of this study is to examine causes of the debris avalanche disaster occurred in Kitamura area using applied geological technique. The length of the debris avalanche scar is about 250m, and alluvial fan is formed as a debris slope. The ground is composed of weathered granite and the bottom of the valley was filled by soils derived from disintegrated granite. There are three small landslides as head scarps with steep slopes at approximately 30°-35°. The debris avalanche was inferred to have started as a shallow soil slip at the head by rainfall. 3 major causes are inferred which originated the debris avalanche in the study area; steep slope, ground composed of weathered granite, existence of sandy soil which occupied at the bottom of valley. |
| Keywords | debris avalanche steep slope weathered granite |
| Publication Title | Okayama University Earth Science Report |
| Published Date | 2013-12-27 |
| Volume | volume20 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 1340-7414 |
| language | Japanese |
| Copyright Holders | © 2013 by Okayama University Earth Science Reports Editorial Committee All Rights Reserved |
| File Version | publisher |
| NAID | 120005394592 |
| JaLCDOI | 10.18926/AMO/52145 |
|---|---|
| FullText URL | 68_1_53.pdf |
| Author | Terasaka, Tomohiro| Ueta, Eijiro| Ebara, Hirotaka| Waseda, Koichi| Hanayama, Yoshihisa| Takaki, Akinobu| Kawabata, Tomoko| Sugiyama, Hitoshi| Hidan, Ko| Otsuka, Fumio| |
| Abstract | A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patientʼs serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconiʼs syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis. |
| Keywords | adefovir dipivoxil (ADV) eldecalcitol Fanconi's syndrome hypophosphatemia osteomalacia |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 53 |
| End Page | 56 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553490 |
| JaLCDOI | 10.18926/AMO/52144 |
|---|---|
| FullText URL | 68_1_47.pdf |
| Author | Ishikawa, Tsutomu| Araki, Motoo| Hirata, Takeshi| Watanabe, Masami| Ebara, Shin| Watanabe, Toyohiko| Nasu, Yasutomo| Kumon, Hiromi| |
| Abstract | We report 3 patients with the rare complication of an indwelling urethral catheter misdirected into the ureter. This is the largest series to date. Patients were referred to us for a variety of reasons following exchange of their chronic indwelling urinary catheters. CT in all cases demonstrated the urinary catheters residing in the left ureter. The ages of the patients were 37, 67 and 81 years old. All patients suffered from neurogenic bladder. Two patients were female, one was male, and 2 of the 3 had a sensory disorder inhibiting their pain response. The catheters were replaced with open-end Foley catheters. Extensive follow-up CT scans were obtained in one case, demonstrating improvement of hydronephrosis and no evidence of ureteral stenosis. Cystoscopy in this patient demonstrated normally positioned and functioning ureteral orifices. Although the placement of an indwelling urethral catheter is a comparatively safe procedure, one must keep in mind that this complication can occur, particularly in female patients with neurogenic bladder. CT without contrast is a noninvasive, definitive diagnostic tool. |
| Keywords | complication indwelling urethral catheter imaging computed tomography ureter |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 47 |
| End Page | 51 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553489 |
| Web of Science KeyUT | 000331592800008 |
| JaLCDOI | 10.18926/AMO/52143 |
|---|---|
| FullText URL | 68_1_43.pdf |
| Author | Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki| |
| Abstract | The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p＝0.7709, women:p＝0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese. |
| Keywords | proteinuria estimated glomerular filtration rate (eGFR) lifestyle modification |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 43 |
| End Page | 46 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553488 |
| Web of Science KeyUT | 000331592800007 |
| JaLCDOI | 10.18926/AMO/52142 |
|---|---|
| FullText URL | 68_1_35.pdf |
| Author | Araki, Motoo| Jeong, Wooju| Park, Sung Yul| Lee, Young Hoon| Nasu, Yasutomo| Kumon, Hiromi| Hong, Sung Joon| Rha, Koon Ho| |
| Abstract | The purpose of this study was to compare the positive surgical margin (PSM) rates of 2 techniques of robot-assisted radical prostatectomy (RARP) for pT2 (localized) prostate cancer. A retrospective analysis was conducted of 361 RARP cases, performed from May 2005 to September 2008 by a single surgeon (KHR) at our institution (Yonsei University College of Medicine). In the conventional technique, the bladder neck was transected first. In the modified ultradissection, the lateral border of the bladder neck was dissected and then the bladder neck was transected while the detrusor muscle of the bladder was well visualized. Perioperative characteristics and outcomes and PSM rates were analyzed retrospectively for pT2 patients (n＝217), focusing on a comparison of those undergoing conventional (n＝113) and modified ultradissection (n＝104) techniques. There was no difference between the conventional and modified ultradissection group in mean age, BMI, PSA, prostate volume, biopsy Gleason score, and DʼAmico prognostic criteria distributions. The mean operative time was shorter (p＜0.001) and the estimated blood loss was less (p＜0.01) in the modified ultradissection group. The PSM rate for the bladder neck was significantly reduced by modified ultradissection, from 6.2% to 0% (p＜0.05). In conclusion, modified ultradissection reduces the PSM rate for the bladder neck. |
| Keywords | robot-assisted radical prostatectomy prostate cancer surgery surgical margin technique |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 35 |
| End Page | 41 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553487 |
| Web of Science KeyUT | 000331592800006 |
| JaLCDOI | 10.18926/AMO/52141 |
|---|---|
| FullText URL | 68_1_27.pdf |
| Author | Yoshida, Masao| Ishikawa, Mamoru| Karita, Kanae| Kokaze, Akatsuki| Harada, Matsuko| Take, Shinichiro| Ohno, Hideki| |
| Abstract | To clarify whether high blood pressure (BP) and high body mass index (BMI) are associated with elevated intraocular pressure (IOP), a cross-sectional and longitudinal study was conducted. This epidemiological study analyzed health examination data obtained between 2001 and 2005 from 896 Japanese individuals (aged 32-79 years) who had not undergone any ocular surgery or medical treatment for hypertension, ocular hypertension, or glaucoma. Multiple-regression analysis of our cross-sectional data showed that systolic and diastolic BP (SBP and DBP) and BMI had significant and near-significant positive associations with IOP in men (p＜0.05) and women (p＜0.1). Our longitudinal study from analyses of covariance found that the adjusted mean level of changes in IOP tended to increase with increased levels of SBP, DBP, and BMI in men (p＜0.1). In women also, changes in SBP and BMI tended to be positively related with that of IOP (p＜0.1). The results of this study suggested that BP and BMI were positively associated with IOP in middle-aged and older Japanese. Therefore, management of BP and improvement of obesity might be especially important to Japanese patients with open-angle glaucoma or ocular hypertension as they have a higher incidence of normal-tension glaucoma than Europeans and Americans. |
| Keywords | intraocular pressure blood pressure body mass index epidemiology glaucoma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 27 |
| End Page | 34 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553486 |
| Web of Science KeyUT | 000331592800005 |
| JaLCDOI | 10.18926/AMO/52140 |
|---|---|
| FullText URL | 68_1_23.pdf |
| Author | Ueno, Tsuyoshi| Toyooka, Shinichi| Fukazawa, Takuya| Kubo, Takafumi| Soh, Junichi| Asano, Hiroaki| Muraoka, Takayuki| Tanaka, Norimitsu| Maki, Yuho| Shien, Kazuhiko| Furukawa, Masashi| Sakaguchi, Masakiyo| Yamamoto, Hiromasa| Tsukuda, Kazunori| Miyoshi, Shinichiro| |
| Abstract | The microRNA-34s (miR-34s) have p53 response elements in their 5ʼ-flanking regions and demonstrate tumor-suppressive functions. In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. We subcutaneously transplanted NCI-H290, a human MPM cell line, into BALB/C mice and injected adenovirus vector expressing miR-34b/c, luciferase driven by the cytomegalovirus promoter (Ad-miR-34b/c or Ad-Luc), or PBS control into tumors over 5mm in diameter. A statistically significant growth inhibition of the tumor volume was observed in the Ad-miR-34b/c group from day 6 onward compared to the Ad-Luc group. The inhibition rate of Ad-miR-34b/c, compared to the tumor volume treated with Ad-Luc, was 58.6% on day 10 and 54.7% on day13. Our results indicate that adenovirus-mediated miR-34b/c gene therapy could be useful for the clinical treatment of MPM. |
| Keywords | mesothelioma microRNA microRNA-34b/c p53 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 23 |
| End Page | 26 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553485 |
| Web of Science KeyUT | 000331592800004 |
| JaLCDOI | 10.18926/AMO/52139 |
|---|---|
| FullText URL | 68_1_17.pdf |
| Author | Moritou, Yuki| Ikeda, Fusao| Iwasaki, Yoshiaki| Baba, Nobuyuki| Takaguchi, Kouichi| Senoh, Tomonori| Nagano, Takuya| Takeuchi, Yasuto| Yasunaka, Tetsuya| Ohnishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
| Abstract | The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p＝0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p＝0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p＝0.049, and ＜0.001, respectively). The SNP genotype of PNPLA3 and LDL receptor did not have a significant impact on therapeutic outcomes. With respect to the SNP sites examined, the SNP of PNPLA3 has a weak association with severe hepatic steatosis, but not with the outcome of interferon therapy. |
| Keywords | hepatic steatosis genetic polymorphism interferon HCV |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 17 |
| End Page | 22 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553484 |
| Web of Science KeyUT | 000331592800003 |
| JaLCDOI | 10.18926/AMO/52138 |
|---|---|
| FullText URL | 68_1_7.pdf |
| Author | Horimoto, Naoya| Kitamura, Shinji| Tsuji, Kenji| Makino, Hirofumi| |
| Abstract | Immunosuppressive agents are generally administered to treat kidney diseases. However, it is unclear whether renal stem/progenitor cells are directly affected by the immunosuppressive agents. We used normal rat kidney cells, ureteric bud cells and rat kidney stem/progenitor cells in this study. Mizoribine (MZR), cyclophosphamide (CPA) and cyclosporine (CyA) were added to the culture media of these cells. We evaluated the effects of these immunosuppressive agents on cell proliferation using an electrical cell-substrate impedance sensing system (ECIS) and their effects on the process of renal regeneration using the ischemia-reperfusion (I/R) injury rat model. The ECIS data showed that proliferation of each of the 3 types of cells was significantly suppressed by MZR. MZR treatment enhanced renal tubular injury in ischemia-reperfusion (I/R) injured rats, and significantly decreased levels of M-phase cells and Nestin-positive cells. These results suggested that MZR inhibits the cell cycle of renal stem/progenitor cells;thus, physicians should take note that MZR might affect not only inflammation but also renal regeneration. |
| Keywords | cell biology immunosuppression stem cells |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 15 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553483 |
| Web of Science KeyUT | 000331592800002 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52247 |
| JaLCDOI | 10.18926/AMO/52137 |
|---|---|
| FullText URL | 68_1_1.pdf |
| Author | Tanihara, Shinichi| Imatoh, Takuya| Momose, Yoshito| |
| Abstract | Setting public health priorities requires precise estimation of the burden of disease, including disease-specific medical expenditure. Information on multiple and ruled-out diagnoses on health insurance claims (HICs) has been ignored in traditional analyses of disease-specific medical expenditures in Japan. This study reviewed 448 inpatients with at least one diagnosis of sepsis on their HICs, who were insured by corporate health insurance organizations making claims on services provided from April 2006 to March 2007 in Japan. Subjects in whom sepsis-related diagnoses were specified as “ruled-out” were compared with subjects in whom sepsis-related diagnoses were classified as “not-ruled-out” (i.e., subjects in whom sepsis was considered possibly or likely present). Direct medical expenditure, length of stay (LOS), cost per day, cost of antibiotics, and proportion of administered cephalosporin and carbapenems were significantly higher in subjects classified as not-rule-out. When using health insurance claims in Japan, the statistics of medical expenditures and LOS are influenced by procedures performed to rule out a diagnosis, as well as those performed to treat a confirmed diagnosis of sepsis. |
| Keywords | health insurance claims length of stay medical expenditures ruled-out diagnoses sepsis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-02 |
| Volume | volume68 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24553482 |
| Web of Science KeyUT | 000331592800001 |
| Author | Tanaka, Yoshiyuki| |
|---|---|
| Published Date | 2014-02-01 |
| Publication Title | 岡山大学農学部学術報告 |
| Volume | volume103 |
| Content Type | Departmental Bulletin Paper |
