検索結果 - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Involvement of ADAM12 in TGF-β1-Induced Proliferation of Rheumatoid Arthritis Synovial Fibroblasts

JaLCDOI	10.18926/AMO/70450
FullText URL	80_2_075.pdf
Author	Lin, Deting\| Horita, Masahiro\| Watanabe, Masahito\| Hasei, Joe\| Ohtsuki, Takashi\| Otsuka, Noriaki\| Ichikawa, Chinatsu\| Shimizu, Noriyuki\| Naniwa, Shuichi\| Ozaki, Toshifumi\| Nishida, Keiichiro\|
Abstract	A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and is upregulated in the synovial tissue of osteoarthritis (OA). However, the underlying mechanisms of ADAM12 on rheumatoid arthritis (RA) synovial cell proliferation remain unknown. Here, we investigated the role of ADAM12 in the proliferation of RA synovial fibroblasts (RASFs). The expression and localization of ADAM12 in RA synovial tissues were examined by immunohistochemistry and compared with OA and healthy control (HC) synovial tissues. The effect of inflammatory cytokines (TNF-α, TGF-β1, and PDGF-BB) on ADAM12 expression in RASFs from RA patients was examined by real-time RT-PCR. The effect of ADAM12 knock-down by ADAM12 siRNA and ADAM12 overexpression on cell proliferation of RASFs were examined by WST-1 assay. ADAM12 was identified predominantly in RA synovial tissue rather than OA and HC synovial tissues. Stimulation with TGF-β1 upregulated the expression of ADAM12 and cell proliferation of RASFs. ADAM12 siRNA suppressed TGF-β1-induced cell proliferation of RASFs, while ADAM12 overexpression promoted the cell proliferation of RASFs. These findings demonstrate that ADAM12 may have a key role in TGF-β1-induced cell proliferation of synovial fibroblasts in patients with RA.
Keywords	rheumatoid arthritis synovial tissue TGF-β1 ADAM12 cell proliferation
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2026-04
Volume	volume80
Issue	issue2
Publisher	Okayama University Medical School
Start Page	75
End Page	83
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2026 by Okayama University Medical School
File Version	publisher
Refereed	True

Virome of the fungi associated with mushroom dry bubble disease

FullText URL	fulltext.pdf
Author	Hatvani, Lóránt\| Hisano, Sakae\| Kondo, Hideki\| Sugahara, Hitomi\| Telengech, Paul\| Shahi, Sabitree\| Ibiang, Sarah Remi\| Kocsubé, Sándor\| Kartali, Tünde\| Fitzpatrick, David A.\| Grogan, Helen\| Suzuki, Nobuhiro\|
Keywords	Lecanicillium fungicola Agaricus bisporus Akanthomyces Simplicillium dsRNA Myovirus Fungal virus Mycovirgaviridae Partitiviridae Polymycoviridae Botourmiaviridae Splipalmiviridae Narna-like virus
Published Date	2026-05
Publication Title	Virus Research
Volume	volume367
Publisher	Elsevier BV
Start Page	199714
ISSN	0168-1702
NCID	AA10642076
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	41856379
DOI	10.1016/j.virusres.2026.199714
Web of Science KeyUT	001734178800001
Related Url	isVersionOf https://doi.org/10.1016/j.virusres.2026.199714

Short- and long-term outcomes of anti-thymocyte globulin-based regimen for acute antibody-mediated rejection after lung transplantation

FullText URL	fulltext.pdf
Author	Miyoshi, Kentaroh\| Otani, Shinji\| Sugimoto, Seiichiro\| Tanaka, Shin\| Okazaki, Mikio\| Toyooka, Shinichi\|
Keywords	Anti-thymocyte globulin Acute antibody-mediated rejection Treatment Lung transplantation
Published Date	2026-05
Publication Title	Respiratory Investigation
Volume	volume64
Issue	issue3
Publisher	Elsevier BV
Start Page	101428
ISSN	2212-5345
NCID	AA12579673
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Authors.
File Version	publisher
DOI	10.1016/j.resinv.2026.101428
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Solution-Processable Near-Infrared-Absorbing Dye: Thiophene-Substituted N-Phenylphenothiazine Radical Cations for Stable Thin Films

FullText URL	fulltext.pdf
Author	Yano, Masafumi\| Sakai, Kengo\| Ueda, Minami\| Mitsudo, Koichi\| Kashiwagi, Yukiyasu\|
Keywords	N-phenylphenothiazine radical cation thiophene substitution near-infrared absorption stability in solid state
Published Date	2026-04-16
Publication Title	Colorants
Volume	volume5
Issue	issue2
Publisher	MDPI AG
Start Page	14
ISSN	2079-6447
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 by the authors.
File Version	publisher
DOI	10.3390/colorants5020014
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Transverse- and Axial-Flux Permanent Magnet Machine With C-Type SMC Stator: A Solution for Ultra-Flat Applications

FullText URL	fulltext.pdf
Author	Tsunata, Ren\| Takemoto, Masatsugu\| Imai, Jun\| Saito, Tatsuya\| Ueno, Tomoyuki\|
Keywords	Axial-flux machine coreless rotor structure C-shaped core efficiency (IE5 class) permanent magnet synchronous machine (PMSM) short axial length soft magnetic composite (SMC) transverse-flux machine ultra-flat shape
Published Date	2026-04
Publication Title	IEEE Transactions on Industrial Electronics
Volume	volume73
Issue	issue4
Publisher	Institute of Electrical and Electronics Engineers (IEEE)
Start Page	5942
End Page	5953
ISSN	0278-0046
NCID	AA10629318
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Authors.
File Version	publisher
DOI	10.1109/tie.2025.3629360
Web of Science KeyUT	001643533800001
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Electrochemical Synthesis of Benzo[b]Phosphole Oxides via Dehydrogenative Annulation Using 1,4-Diazabicyclo [2.2.2]Octane as a Mediator

FullText URL	fulltext.pdf
Author	Mitsudo, Koichi\| Kinjo, Sakura\| Okumura, Yasuyuki\| Sato, Eisuke\| Kato, Riki\| Nishina, Yuta\| Suga, Seiji\|
Keywords	annulation benzophosphole oxide electrochemistry hydrogen atom transfer radical cyclization
Published Date	2026-04-15
Publication Title	ChemElectroChem
Volume	volume13
Issue	issue8
Publisher	Wiley
Start Page	e70175
ISSN	2196-0216
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
DOI	10.1002/celc.70175
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Muscle Atrophy-Related Adverse Events of Antidiabetic Drug Classes: A Pharmacovigilance Analysis Using VigiBase Data

FullText URL	fulltext.pdf
Author	Ueta, Shiho\| Niimura, Takahiro\| Goda, Mitsuhiro\| Ishida, Tomoaki\| Iwata, Naohiro\| Takeda, Tatsuaki\| Kawada, Kei\| Miyata, Koji\| Aizawa, Fuka\| Yagi, Kenta\| Hamano, Hirofumi\| Chuma, Masayuki\| Izawa‐Ishizawa, Yuki\| Zamami, Yoshito\| Ishizawa, Keisuke\|
Keywords	antidiabetic drug muscle atrophy sarcopenia VigiBase
Published Date	2026-04
Publication Title	Journal of Cachexia, Sarcopenia and Muscle
Volume	volume17
Issue	issue2
Publisher	Wiley
Start Page	e70251
ISSN	2190-5991
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	41980862
DOI	10.1002/jcsm.70251
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ROWVA: A Structure-Based Metric for Predicting the Pathogenicity of Protein Variants Using Alphafold2

FullText URL	fulltext.pdf
Author	Furutani, Taiki\| Okusha, Yuka\| Nagami, Hiroki\| Hanafusa, Hiroko\| Tomida, Shuta\| Sawada, Ryusuke\| Hosono, Yasuyuki\| Nakatochi, Masahiro\|
Keywords	3D protein structural prediction AlphaFold2 p53 tumor suppressor variants of uncertain significance
Published Date	2026-04-07
Publication Title	Cancer Science
Publisher	Wiley
ISSN	1347-9032
NCID	AA11808050
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	41944209
DOI	10.1111/cas.70380
Web of Science KeyUT	001733684100001
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Global trends in systemic sclerosis-related mortality, 2001–2023: an epidemiological analysis using World Health Organization mortality data

FullText URL	fulltext.pdf
Author	Belangoy, Keith Pardillada\| Nishimura, Yoshito\| Harada, Ko\| Hagiya, Hideharu\| Vu, Quynh Thi\| Ouddoud, Hanane\| Lescano, Judah Israel Ong\| Yamamoto, Michio\| Takeda, Tatsuaki\| Hamano, Hirofumi\| Koyama, Toshihiro\| Zamami, Yoshito\|
Keywords	Age-standardized mortality rate Global health Mortality trends Sociodemographic index Systemic sclerosis
Published Date	2026-03-06
Publication Title	Clinical Rheumatology
Volume	volume45
Issue	issue5
Publisher	Springer Science and Business Media LLC
Start Page	2741
End Page	2748
ISSN	0770-3198
NCID	AA10623843
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2026
File Version	publisher
PubMed ID	41790357
DOI	10.1007/s10067-026-07995-2
Web of Science KeyUT	001712341500001
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Rice EMF3 Alleles Adjust Flower Opening Time to Enhance the Seed Setting Rate Under High Temperature Stress

FullText URL	fulltext.pdf
Author	Ishizaki, Takuma\| Hashida, Yoichi\| Hirabayashi, Hideyuki\| Sasaki, Kazuhiro\| Tokunaga, Hiroki\| Simon‐Ada, Eliza Vie M.\| Wakayama, Masataka\| Takai, Toshiyuki\| Saito, Hiroki\| Nagano, Atsushi J.\| Sakakibara, Hitoshi\| Kojima, Mikiko\| Takebayashi, Yumiko\| Kim, Sung‐Ryul\| Matsushima, Ryo\| Thomson, Michael J.\| Sugimoto, Kazuhiko\| Hibara, Ken‐Ichiro\| Ishimaru, Tsutomu\|
Keywords	EARLY-MORNING FLOWERING 3 flower opening time heat stress rice seed setting rate
Published Date	2026-04-09
Publication Title	Plant Biotechnology Journal
Publisher	Wiley
ISSN	1467-7644
NCID	AA11805223
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	41954325
DOI	10.1111/pbi.70653
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Synthesis of sulfur- and oxygen-bridged cationic [4]-helicenes mediated by Friedel–Crafts-S <sub>N</sub> Ar tandem reactions for red-light-driven organophotoredox catalysis

FullText URL	fulltext.pdf
Author	Hasebe, Ryoga\| Hanada, Rumi\| Tanaka, Yuta\| Goto, Yuta\| Takeuchi, Mio\| Takamura, Hiroyoshi\| Kadota, Isao\| Tanaka, Kenta\| Hoshino, Yujiro\|
Published Date	2026
Publication Title	Chemical Communications
Publisher	Royal Society of Chemistry (RSC)
ISSN	1359-7345
NCID	AA11071130
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Royal Society of Chemistry 2026
File Version	publisher
PubMed ID	41948888
DOI	10.1039/d5cc07398g
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Analytical and numerical studies of periodic superradiance

FullText URL	fulltext20260414-01.pdf
Author	Hara, Hideaki\| Miyamoto, Yuki\| Han, Junseok\| Omoto, Riku\| Imai, Yasutaka\| Yoshimi, Akihiro\| Yoshimura, Koji\| Yoshimura, Motohiko\| Sasao, Noboru\|
Note	This is an Accepted Manuscript of an article published by American Physical Society.\|
Published Date	2026-04-08
Publication Title	Physical Review A
Volume	volume113
Issue	issue4
Publisher	American Physical Society (APS)
Start Page	043713
ISSN	2469-9926
NCID	AA10764867
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2026 American Physical Society
File Version	author
DOI	10.1103/fvvx-wtyd
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Pseudohypoxia induced by iron chelators preserves working memory performance in aged mice

FullText URL	fulltext.pdf
Author	Ohara, Toshiaki\| Iwasaki, Yoshiaki\| Kasai, Tomonari\| Yamashita, Toru\| Komaki, Shiho\| Hamada, Yusuke\| Fujisawa, Masayoshi\| Matsukawa, Akihiro\|
Keywords	Hypoxia-inducible factor Working memory Hippocampus Iron
Published Date	2026-03-02
Publication Title	Scientific Reports
Volume	volume16
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	11550
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2026 Scientific
File Version	publisher
PubMed ID	41772141
DOI	10.1038/s41598-026-42296-3
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P53-armed Oncolytic Adenovirus Enhances the Efficacy of PD-1 Blockade in Neuroblastoma by Inducing Immunogenic Cell Death

FullText URL	fulltext.pdf
Author	TANI, MORIMICHI\| TAZAWA, HIROSHI\| TANIMOTO, TERUTAKA\| NOUSO, HIROSHI\| WATANABE, HINAKO\| OYAMA, TAKANORI\| URATA, YASUO\| KAGAWA, SHUNSUKE\| NODA, TAKUO\| KURODA, SHINJI\| FUJIWARA, TOSHIYOSHI\|
Keywords	Neuroblastoma oncolytic adenovirus p53 immunogenic cell death PD-1
Published Date	2026-03-27
Publication Title	Anticancer Research
Volume	volume46
Issue	issue4
Publisher	International Institute of Anticancer Research
Start Page	1769
End Page	1784
ISSN	0250-7005
NCID	AA10625860
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2026 The Author(s).
File Version	publisher
PubMed ID	41895769
DOI	10.21873/anticanres.18073
Web of Science KeyUT	001730394100003
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Informatics‐Driven and Automated Optimization in Flow Electrochemical Synthesis

Author	Sato, Eisuke\| Tani, Akine\| Nakahama, Tomohiro\| Mitsudo, Koichi\| Suga, Seiji\|
Keywords	artificial intelligence electrochemical synthesis flow synthesis laboratory automation
Note	This is the peer reviewed version of the following article: EisukeSato, AkineTani, TomohiroNakahama, KoichiMitsudo, SeijiSuga, European Journal of Organic Chemistry2026, 0, e202501237. https://doi.org/10.1002/ejoc.202501237, which has been published in final form at https://doi.org/10.1002/ejoc.202501237. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\| This fulltext file will be available in Apr. 2027.\|
Published Date	2026-04-03
Publication Title	European Journal of Organic Chemistry
Publisher	Wiley
Start Page	e202501237
ISSN	1434-193X
NCID	AA1118165X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 Wiley-VCH GmbH
File Version	author
DOI	10.1002/ejoc.202501237
Web of Science KeyUT	001731515200001
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Constitutive activation of MC1R in the large-billed crow (Corvus macrorhynchos) and its potential role in black plumage

Author	Nakano, Saya\| Tashiro, Yuichi\| Fukuchi, Hibiki\| Aizawa, Sayaka\| Takeuchi, Sakae\|
Keywords	MC1R Constitutive activation Ligand-independent signaling Melanism Plumage coloration Corvus macrorhynchos
Note	© 2026 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/\| This fulltext file will be available in Apr. 2027.\|
Published Date	2026-04
Publication Title	General and Comparative Endocrinology
Volume	volume380
Publisher	Elsevier BV
Start Page	114924
ISSN	0016-6480
NCID	AA00654410
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 Elsevier Inc.
File Version	author
DOI	10.1016/j.ygcen.2026.114924
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Improving thermal stability of a microcavity emitter for utilization under atmospheric environment

FullText URL	fulltext.pdf
Author	Isobe, Kazuma\| Morishige, Shota\| Sato, Taiyo\| Yamada, Yutaka\| Horibe, Akihiko\|
Keywords	Metamaterial Microcavity emitter Emissivity spectrum Thermal stability Tungsten oxidation Eutectic melting
Published Date	2026-08
Publication Title	International Journal of Heat and Mass Transfer
Volume	volume264
Publisher	Elsevier BV
Start Page	128798
ISSN	0017-9310
NCID	AA00680396
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
DOI	10.1016/j.ijheatmasstransfer.2026.128798
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The Simons Observatory: Detector Polarization Angle Calibration Using a Sparse Wire Grid with Initial Datasets of the Small-aperture Telescopes

FullText URL	fulltext.pdf
Author	Nakata, Hironobu\| Adachi, Shunsuke\| Yamada, Kyohei\| Randall, Michael\| Kasai, Yutaro\| Arnold, Kam\| Bixler, Bryce\| Chinone, Yuji\| Crowley, Kevin T.\| Dachlythra, Nadia\| Day-Weiss, Samuel\| Galitzki, Nicholas\| Giardiello, Serena\| Johnson, Bradley R.\| Keating, Brian\| Koopman, Brian J.\| Kusaka, Akito\| Lashner, Jack\| Nati, Federico\| Page, Lyman\| Sasaki, Daichi\| Sueno, Yoshinori\| Suzuki, Junya\| Tajima, Osamu\| Tsan, Tran\|
Published Date	2026-04-01
Publication Title	The Astrophysical Journal Supplement Series
Volume	volume283
Issue	issue2
Publisher	American Astronomical Society
Start Page	78
ISSN	0067-0049
NCID	AA00553297
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026. The Author(s).
File Version	publisher
DOI	10.3847/1538-4365/ae4ddf
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Knot surgered elliptic surfaces without 1- and 3-handles for a (2, 2h + 1)-torus knot

FullText URL	fulltext.pdf
Author	Monden, Naoyuki\| Yabuguchi, Reo\|
Published Date	2026-04-04
Publication Title	Geometriae Dedicata
Volume	volume220
Issue	issue3
Publisher	Springer Science and Business Media LLC
Start Page	29
ISSN	0046-5755
NCID	AA0065688X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2026
File Version	publisher
DOI	10.1007/s10711-026-01079-w
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Investigating the Detectability of Body Wave Phases From Tidal Ice Cracking Events on Titan With the Dragonfly Short-Period Seismometer

FullText URL	fulltext.pdf
Author	Delaroque, L.\| Kawamura, T.\| Lucas, A.\| Rodriguez, S.\| Onodera, K.\| Shiraishi, H.\| Yamada, R.\| Tanaka, S.\| Panning, M. P.\| Lorenz, R. D.\|
Keywords	body waves planetary seismology interior structure dragonfly mission icy moons Titan
Published Date	2026-04
Publication Title	Journal of Geophysical Research: Planets
Volume	volume131
Issue	issue4
Publisher	American Geophysical Union (AGU)
Start Page	e2025JE009432
ISSN	2169-9097
NCID	AA10815334
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
DOI	10.1029/2025je009432
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