start-ver=1.4
cd-journal=joma
no-vol=80
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=30
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2026
dt-pub=202602
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of a Stroke Discharge Support Evaluation Scale for Ward Nurses in Acute Care Hospitals
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study aimed to develop a scale enabling nurses to objectively evaluate their own stroke discharge support, as a basis for enhancing its overall effectiveness. A draft scale was created based on a literature review, and consisted of a 51-item, 5-point Likert-type questionnaire administered to ward nurses engaged in stroke discharge support at acute care hospitals. Factor analysis was performed to refine the scale. Construct validity was assessed using the known-groups method, and reliability was evaluated through internal consistency analysis. The resulting Stroke Discharge Support Evaluation Scale comprises 29 items across 5 factors, each rated on a 5-point Likert scale. Analysis of the data collected from 237 valid responses demonstrated good internal consistency and supported the scale�fs construct validity. The Stroke Discharge Support Evaluation Scale is a reliable and valid tool enabling ward nurses in acute care hospitals to evaluate their own stroke discharge support.
en-copyright=
kn-copyright=

en-aut-name=YanoHideki
en-aut-sei=Yano
en-aut-mei=Hideki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakahataYoko
en-aut-sei=Takahata
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamaguchiTakeshi
en-aut-sei=Yamaguchi
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SaitoShinya
en-aut-sei=Saito
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Nursing, Faculty of Human Health Sciences, Niimi University
kn-affil=

affil-num=2
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Faculty of Nursing, Shikoku University
kn-affil=

affil-num=4
en-affil=Graduate School of Health Sciences, Okayama University
kn-affil=
en-keyword=stroke
kn-keyword=stroke
en-keyword=discharge support
kn-keyword=discharge support
en-keyword=scale development
kn-keyword=scale development
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2026
dt-pub=20260212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Influence of Fluidic Flow Stress on the Development of the Secondary Palate
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Craniofacial development is orchestrated by a finely regulated interplay of numerous genes and signaling pathways. Palatogenesis proceeds through a complex, stepwise process, in which endogenous mechanical stresses within tissues have been implicated. However, the impact of exogenous fluidic flow mechanical stress derived from maternal movement on palatal development remains unclear. In this study, we investigated the effect of exogenous fluidic flow mechanical stress on palatal morphogenesis, focusing on the horizontal outgrowth of palatal shelves after elevation. Palatal tissues dissected from mouse embryos were subjected to organ culture with or without mechanical loading (loaded and unloaded groups, respectively). Stress magnitude was quantified by calculating wave energy, and morphometric and molecular analyses were performed. Compared with the unloaded group, palatal shelves in the loaded group showed significant increases in thickness and volume, accompanied by enhanced cell proliferation, nuclear translocation of YAP and ƒÀ-catenin, and upregulation of the osteogenic markers Osterix and Osteocalcin. No significant difference in apoptosis was observed. These findings indicate that exogenous mechanical stress promotes cell proliferation and osteogenic differentiation through the Hippo and WNT/ƒÀ-catenin pathways in palate explants. Our results suggest that moderate maternal movement-induced mechanical stress contributes to normal palatogenesis, providing new insights into the mechanisms underlying cleft palate.
en-copyright=
kn-copyright=

en-aut-name=NagataMasayo
en-aut-sei=Nagata
en-aut-mei=Masayo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HayanoSatoru
en-aut-sei=Hayano
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangZiyi
en-aut-sei=Wang
en-aut-mei=Ziyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KosamiTakahiro
en-aut-sei=Kosami
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=mechanical stress
kn-keyword=mechanical stress
en-keyword=palatal development
kn-keyword=palatal development
en-keyword=ƒÀ-catenin
kn-keyword=ƒÀ-catenin
en-keyword=YAP
kn-keyword=YAP
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250909
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Current Status of Continuous Renal Replacement Therapy in Japanese Intensive Care Units: A Multicenter Retrospective Observational Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Introduction: Continuous renal replacement therapy (CRRT) is often performed for critically ill patients in intensive care units (ICUs), but its optimal indication and settings have yet to be determined. Thus, we aimed to describe the current status of CRRT in Japan through a multicenter retrospective observational study. Methods: Adult ICU patients receiving CRRT at 18 tertiary hospitals in Japan (up to 100 patients from each hospital over the past year) were retrospectively enrolled. Patients receiving CRRT for <24 h or intermittent renal replacement therapy together with CRRT were excluded. The primary outcomes were the temporal changes in the electrolyte levels, acid-base balance, and uremia-related small solute concentrations. The secondary outcomes included potassium (K) and phosphate (P) supplementations during CRRT. Results: Altogether, 1,045 patients were enrolled. The median CRRT duration and dose were 4.4 days and 17.3 mL/kg/h, respectively. The electrolyte levels, acid-base balance, and uremia-related small solute concentrations returned to normal by day 4 of treatment. A total of 732 (70.0%) patients received K supplementation, and only a few patients had hypokalemia until day 5. Moreover, 414 (39.6%) patients received P supplementation, and approximately 30%?50% of the patients had hypophosphatemia until day 5. Conclusion: The CRRT dose in Japan was lower than that was recommended by the Kidney Disease: Improving Global Outcomes guideline. The electrolyte level abnormalities and acid-base imbalances of the studied patients were improved within 72?96 h of CRRT. Contrarily, K and P supplementations were common, indicating that the current CRRT solutions need to be modified.
en-copyright=
kn-copyright=

en-aut-name=NakanoHidehiko
en-aut-sei=Nakano
en-aut-mei=Hidehiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=InokuchiRyota
en-aut-sei=Inokuchi
en-aut-mei=Ryota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=InoueYutaro
en-aut-sei=Inoue
en-aut-mei=Yutaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SekinoMotohiro
en-aut-sei=Sekino
en-aut-mei=Motohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KakihanaYasuyuki
en-aut-sei=Kakihana
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HattoriNoriyuki
en-aut-sei=Hattori
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyazakiMariko
en-aut-sei=Miyazaki
en-aut-mei=Mariko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TokuhiraNatsuko
en-aut-sei=Tokuhira
en-aut-mei=Natsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=FujitaniShigeki
en-aut-sei=Fujitani
en-aut-mei=Shigeki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TodaYuichiro
en-aut-sei=Toda
en-aut-mei=Yuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OhchiYoshifumi
en-aut-sei=Ohchi
en-aut-mei=Yoshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IchibaShingo
en-aut-sei=Ichiba
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=MasudaYoshiki
en-aut-sei=Masuda
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=NishidaOsamu
en-aut-sei=Nishida
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=AbeTakaya
en-aut-sei=Abe
en-aut-mei=Takaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=MoriguchiTakeshi
en-aut-sei=Moriguchi
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=SatohKasumi
en-aut-sei=Satoh
en-aut-mei=Kasumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=IdeiMasafumi
en-aut-sei=Idei
en-aut-mei=Masafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=NagataHiromasa
en-aut-sei=Nagata
en-aut-mei=Hiromasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=DoiKent
en-aut-sei=Doi
en-aut-mei=Kent
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

affil-num=1
en-affil=Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital
kn-affil=

affil-num=2
en-affil=Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital
kn-affil=

affil-num=3
en-affil=Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital
kn-affil=

affil-num=4
en-affil=Department of Anesthesiology and Intensive Care Medicine, Nagasaki University Graduate School of Biomedical Sciences
kn-affil=

affil-num=5
en-affil=Department of Emergency and Intensive Care Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=6
en-affil=Department of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Nephrology, Tohoku University Hospital
kn-affil=

affil-num=8
en-affil=Department of Intensive Care, Osaka University Hospital
kn-affil=

affil-num=9
en-affil=Department of Emergency and Critical Care Medicine, St. Marianna University School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Anesthesiology and Intensive Care Medicine, Kawasaki Medical School
kn-affil=

affil-num=11
en-affil=Department of Anesthesiology and Intensive Care, Oita University Faculty of Medicine
kn-affil=

affil-num=12
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Intensive Care Medicine, Tokyo Women�fs Medical University
kn-affil=

affil-num=14
en-affil=Department of Intensive Care Medicine, Sapporo Medical University School of Medicine
kn-affil=

affil-num=15
en-affil=Department of Anesthesiology and Critical Care Medicine, School of Medicine, Fujita Health University
kn-affil=

affil-num=16
en-affil=Department of Urology, Iwate Medical University
kn-affil=

affil-num=17
en-affil=Department of Emergency and Critical Care Medicine, University of Yamanashi Graduate School of Medicine
kn-affil=

affil-num=18
en-affil=Department of Emergency and Critical Care Medicine, Akita University Graduate School of Medicine
kn-affil=

affil-num=19
en-affil=Department of Intensive Care Medicine, Yokohama City University
kn-affil=

affil-num=20
en-affil=Department of Anesthesiology, Keio University School of Medicine
kn-affil=

affil-num=21
en-affil=Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital
kn-affil=
en-keyword=Acute kidney injury
kn-keyword=Acute kidney injury
en-keyword=Renal failure
kn-keyword=Renal failure
en-keyword=Continuous renal replacement therapy
kn-keyword=Continuous renal replacement therapy
en-keyword=Electrolytes
kn-keyword=Electrolytes
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=34964
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20251007
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Periodontitis associated with Porphyromonas gingivalis infection is a risk factor for infertility through uterine hypertrophy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Periodontitis has recently been recognized as a potential risk factor for infertility due to its adverse effect on conception, although the underlying mechanisms remain unclear. This study investigated serum IgG antibody titers against periodontopathogenic bacteria in women with unexplained infertility and investigated how periodontal inflammation affects pregnancy and uterine function using a ligature-induced periodontitis mouse model infected with Porphyromonas gingivalis (Pg). IgG antibody titers against seven periodontopathogenic bacteria strains were measured by ELISA in 76 spontaneously pregnant women and 70 women undergoing infertility treatment. In the in vivo study, periodontitis mice were bred four weeks after periodontitis induction. Birth numbers, newborn weights, and gestation periods were assessed. To evaluate periodontal inflammation, alveolar bone, serum, and uterus was collected before mating. Uterine tissue was evaluated through histological and immunohistochemical staining. Women receiving infertility treatment were significantly older and had higher IgG titers against three Pg strains. Periodontitis mice had fewer births, lower newborn weights, and increased uterine cross-sectional areas. Additionally, elevated estrogen receptor ƒ¿ and progesterone receptor expression levels were observed in endometrial and stromal tissues. These results suggest that periodontitis may cause uterine hypertrophy and hormone receptor changes, potentially impairing pregnancy.
en-copyright=
kn-copyright=

en-aut-name=Kamei-NagataChiaki
en-aut-sei=Kamei-Nagata
en-aut-mei=Chiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OmoriKazuhiro
en-aut-sei=Omori
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SakoHidefumi
en-aut-sei=Sako
en-aut-mei=Hidefumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SakaidaKyosuke
en-aut-sei=Sakaida
en-aut-mei=Kyosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakayamaMasa-aki
en-aut-sei=Nakayama
en-aut-mei=Masa-aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OharaToshiaki
en-aut-sei=Ohara
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MandaiHiroki
en-aut-sei=Mandai
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=Kubota-TakamoriMoyuka
en-aut-sei=Kubota-Takamori
en-aut-mei=Moyuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KiyamaFumiko
en-aut-sei=Kiyama
en-aut-mei=Fumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IshiiTakayuki
en-aut-sei=Ishii
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HiraiKimito
en-aut-sei=Hirai
en-aut-mei=Kimito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=IkedaAtsushi
en-aut-sei=Ikeda
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=Takeuchi-HatanakaKazu
en-aut-sei=Takeuchi-Hatanaka
en-aut-mei=Kazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=Shinoda-ItoYuki
en-aut-sei=Shinoda-Ito
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=Tai-TokuzenMasako
en-aut-sei=Tai-Tokuzen
en-aut-mei=Masako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=SakamotoAi
en-aut-sei=Sakamoto
en-aut-mei=Ai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=KiyokawaMachiko
en-aut-sei=Kiyokawa
en-aut-mei=Machiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=YamanishiTomomi
en-aut-sei=Yamanishi
en-aut-mei=Tomomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=OdaTakashi
en-aut-sei=Oda
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=TakigawaMasayuki
en-aut-sei=Takigawa
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=YamamotoTadashi
en-aut-sei=Yamamoto
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=MiyakeTakahito
en-aut-sei=Miyake
en-aut-mei=Takahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=TakashibaShogo
en-aut-sei=Takashiba
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

affil-num=1
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Oral Microbiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Pharmacy, Faculty of Pharmacy, Gifu University of Medical Science
kn-affil=

affil-num=8
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=14
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=16
en-affil=Center for Reproductive Medicine, Miyake Clinic
kn-affil=

affil-num=17
en-affil=Center for Reproductive Medicine, Miyake Clinic
kn-affil=

affil-num=18
en-affil=Center for Reproductive Medicine, Miyake Clinic
kn-affil=

affil-num=19
en-affil=Center for Reproductive Medicine, Miyake Clinic
kn-affil=

affil-num=20
en-affil=Miyake Hello Dental Clinic, Pediatric Dentistry and Orthodontics
kn-affil=

affil-num=21
en-affil=The Center for Graduate Medical Education (Dental Division), Okayama University Hospital
kn-affil=

affil-num=22
en-affil=Center for Reproductive Medicine, Miyake Clinic
kn-affil=

affil-num=23
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Infertility
kn-keyword=Infertility
en-keyword=Periodontitis
kn-keyword=Periodontitis
en-keyword=Porphyromonas gingivalis
kn-keyword=Porphyromonas gingivalis
en-keyword=Chronic inflammation
kn-keyword=Chronic inflammation
en-keyword=Uterus
kn-keyword=Uterus
en-keyword=Sex hormone receptor
kn-keyword=Sex hormone receptor
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=1
article-no=
start-page=34768
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20251006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Continuous glucose monitoring reveals periodontitis-induced glucose variability, insulin resistance, and gut microbiota dysbiosis in mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Diabetes mellitus (DM) management has advanced from self-monitoring blood glucose (SMBG) to continuous glucose monitoring (CGM), which better prevents complications. However, the influence of periodontitis?a common DM complication?on glucose variability is unclear. This study examined glucose variability in mice with periodontitis using CGM. Periodontitis was induced in 9-week-old male C57BL/6J mice via silk ligatures around the upper second molars. Glucose levels were monitored over 14 days with CGM, validated by SMBG. On day 14, samples were collected to assess alveolar bone resorption and serum levels of tumor necrosis factor-ƒ¿ (TNF-ƒ¿), insulin, and amyloid A. Glucose tolerance test (GTT) and insulin tolerance test (ITT) were conducted to evaluate insulin resistance. Gut microbiota diversity was also analyzed. By day 10, mice with periodontitis exhibited higher mean glucose levels and time above range than controls. On day 14, serum insulin and amyloid A levels significantly increased, while TNF-ƒ¿ remained unchanged. GTT and ITT indicated insulin resistance. Microbiota analysis showed reduced alpha- and altered beta-diversity, with decreased Coprococcus spp. and increased Prevotella spp., linking dysbiosis to insulin resistance. Periodontitis disrupts glucose regulation by promoting insulin resistance and gut microbiota imbalance, leading to significant glucose variability.
en-copyright=
kn-copyright=

en-aut-name=Kubota-TakamoriMoyuka
en-aut-sei=Kubota-Takamori
en-aut-mei=Moyuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OmoriKazuhiro
en-aut-sei=Omori
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Kamei-NagataChiaki
en-aut-sei=Kamei-Nagata
en-aut-mei=Chiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KiyamaFumiko
en-aut-sei=Kiyama
en-aut-mei=Fumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshiiTakayuki
en-aut-sei=Ishii
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakayamaMasaaki
en-aut-sei=Nakayama
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=GotohKazuyoshi
en-aut-sei=Gotoh
en-aut-mei=Kazuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HiraiKimito
en-aut-sei=Hirai
en-aut-mei=Kimito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=Shinoda-ItoYuki
en-aut-sei=Shinoda-Ito
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OkuboKeisuke
en-aut-sei=Okubo
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NakamuraShin
en-aut-sei=Nakamura
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=IkedaAtsushi
en-aut-sei=Ikeda
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SaitoTsugumichi
en-aut-sei=Saito
en-aut-mei=Tsugumichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=TakashibaShogo
en-aut-sei=Takashiba
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Oral Microbiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Medical Laboratory Science, Okayama University Graduate School of Health Sciences
kn-affil=

affil-num=8
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Health & Sports Sciences, Faculty of Education, Tokyo Gakugei University
kn-affil=

affil-num=14
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Continuous glucose monitoring
kn-keyword=Continuous glucose monitoring
en-keyword=Periodontal disease
kn-keyword=Periodontal disease
en-keyword=Insulin resistance
kn-keyword=Insulin resistance
en-keyword=Chronic inflammation
kn-keyword=Chronic inflammation
en-keyword=Gut flora
kn-keyword=Gut flora
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=4
article-no=
start-page=221
end-page=229
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202508
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Organ Donation after Extracorporeal Cardiopulmonary Resuscitation: Clinical and Ethical Perspectives
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Extracorporeal cardiopulmonary resuscitation (ECPR) has evolved into a life-saving therapy for select cardiac arrest patients, yet a growing body of evidence suggests it also holds promise as a bridge to organ donation in non-survivors. This review explores the clinical outcomes, ethical complexities, and evolving policies surrounding organ donation after ECPR. We summarize recent international and Japanese data demonstrating favorable graft function from ECPR donors, with the exception of lung transplantation. The ethical challenges ? particularly those involving brain death determination on extracorporeal membrane oxygenation and adherence to the dead donor rule ? are discussed in the context of Japan�fs recent regulatory reforms. Additionally, we highlight the importance of structured end-of-life communication through multidisciplinary team meetings in facilitating ethically sound transitions from rescue efforts to donation pathways. Moving forward, improvements in donor management, standardized legal frameworks, and public and professional education are essential to optimizing the life-saving and life-giving potential of ECPR.
en-copyright=
kn-copyright=

en-aut-name=YumotoTetsuya
en-aut-sei=Yumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaitoHiromichi
en-aut-sei=Naito
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HongoTakashi
en-aut-sei=Hongo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ObaraTakafumi
en-aut-sei=Obara
en-aut-mei=Takafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KosakiYoshinori
en-aut-sei=Kosaki
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AgetaKohei
en-aut-sei=Ageta
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NojimaTsuyoshi
en-aut-sei=Nojima
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TsukaharaKohei
en-aut-sei=Tsukahara
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=brain death
kn-keyword=brain death
en-keyword=end-of-life care
kn-keyword=end-of-life care
en-keyword=ethical dilemmas
kn-keyword=ethical dilemmas
en-keyword=extracorporeal cardiopulmonary resuscitation
kn-keyword=extracorporeal cardiopulmonary resuscitation
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=5
article-no=
start-page=271
end-page=277
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Japan MSA registry: A multicenter cohort study of multiple system atrophy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic failure and various motor symptoms. While MSA-C (cerebellar type) predominates in East Asia, MSA-P (parkinsonian type) predominates in Europe and North America. This nationwide patient registry aimed to (1) conduct a prospective natural history study of MSA in Japan, (2) facilitate patient recruitment for clinical trials, and (3) deposit bioresources and clinical information in a biobank.<br>
Methods: Thirteen institutions participated in this study. Clinical information was obtained by neurologists from the patients visiting the hospital every 12?months to assess the UMSARS Part 2 scores and by telephone interviews by nurses every 6?months to assess UMSARS Part 1 scores and to determine whether clinical events had occurred.<br>
Results: Demographic data from 329 MSA patients (216 MSA-C and 113 MSA-P) were analyzed. The mean age at symptom onset was 58.2?years (standard deviation, 8.9); the mean duration of symptoms at enrollment was 3.5?years (standard deviation, 2.2). The mean 12-month changes in the UMSARS Part 1 and Part 2 scores were 7.9 (standard deviation, 5.6) and 6.4 (standard deviation, 5.9), respectively. The patient registry proved useful in recruiting participants for clinical trials, including those with gene variants. Clinical information and biospecimens were deposited in a biobank.<br>
Discussion: The study highlighted the importance of telephone interviews in minimizing drop-out rates in natural history studies and demonstrated similar MSA progression rates across populations. The deposited bioresources are available to researchers upon request, aiming to contribute to future MSA researches.
en-copyright=
kn-copyright=

en-aut-name=ChikadaAyaka
en-aut-sei=Chikada
en-aut-mei=Ayaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OrimoKenta
en-aut-sei=Orimo
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MitsuiJun
en-aut-sei=Mitsui
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsukawaTakashi
en-aut-sei=Matsukawa
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshiuraHiroyuki
en-aut-sei=Ishiura
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TodaTatsushi
en-aut-sei=Toda
en-aut-mei=Tatsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MizusawaHidehiro
en-aut-sei=Mizusawa
en-aut-mei=Hidehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakahashiYuji
en-aut-sei=Takahashi
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KatsunoMasahisa
en-aut-sei=Katsuno
en-aut-mei=Masahisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HaraKazuhiro
en-aut-sei=Hara
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OnoderaOsamu
en-aut-sei=Onodera
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=IshiharaTomohiko
en-aut-sei=Ishihara
en-aut-mei=Tomohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=TadaMasayoshi
en-aut-sei=Tada
en-aut-mei=Masayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KuwabaraSatoshi
en-aut-sei=Kuwabara
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=SugiyamaAtsuhiko
en-aut-sei=Sugiyama
en-aut-mei=Atsuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=YamanakaYoshitaka
en-aut-sei=Yamanaka
en-aut-mei=Yoshitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=TakahashiRyosuke
en-aut-sei=Takahashi
en-aut-mei=Ryosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=SawamotoNobukatsu
en-aut-sei=Sawamoto
en-aut-mei=Nobukatsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=SakatoYusuke
en-aut-sei=Sakato
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=IshimotoTomoyuki
en-aut-sei=Ishimoto
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=HanajimaRitsuko
en-aut-sei=Hanajima
en-aut-mei=Ritsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=WatanabeYasuhiro
en-aut-sei=Watanabe
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=TakigawaHiroshi
en-aut-sei=Takigawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

en-aut-name=AdachiTadashi
en-aut-sei=Adachi
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=24
ORCID=

en-aut-name=AbeKoji
en-aut-sei=Abe
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=25
ORCID=

en-aut-name=YamashitaToru
en-aut-sei=Yamashita
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=26
ORCID=

en-aut-name=TakashimaHiroshi
en-aut-sei=Takashima
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=27
ORCID=

en-aut-name=HigashiKeiko
en-aut-sei=Higashi
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=28
ORCID=

en-aut-name=KiraJunichi
en-aut-sei=Kira
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=29
ORCID=

en-aut-name=YabeIchiro
en-aut-sei=Yabe
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=30
ORCID=

en-aut-name=MatsushimaMasaaki
en-aut-sei=Matsushima
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=31
ORCID=

en-aut-name=OgataKatsuhisa
en-aut-sei=Ogata
en-aut-mei=Katsuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=32
ORCID=

en-aut-name=IshikawaKinya
en-aut-sei=Ishikawa
en-aut-mei=Kinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=33
ORCID=

en-aut-name=NishidaYoichiro
en-aut-sei=Nishida
en-aut-mei=Yoichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=34
ORCID=

en-aut-name=IshiguroTaro
en-aut-sei=Ishiguro
en-aut-mei=Taro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=35
ORCID=

en-aut-name=OzakiKokoro
en-aut-sei=Ozaki
en-aut-mei=Kokoro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=36
ORCID=

en-aut-name=NagataTetsuya
en-aut-sei=Nagata
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=37
ORCID=

en-aut-name=TsujiShoji
en-aut-sei=Tsuji
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=38
ORCID=

affil-num=1
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=2
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=3
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=4
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=5
en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry
kn-affil=

affil-num=6
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=7
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=8
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=

affil-num=9
en-affil=Department of Neurology, Nagoya University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Neurology, Nagoya University Graduate School of Medicine
kn-affil=

affil-num=11
en-affil=Department of Neurology, Brain Research Institute, Niigata University
kn-affil=

affil-num=12
en-affil=Department of Neurology, Brain Research Institute, Niigata University
kn-affil=

affil-num=13
en-affil=Department of Neurology, Brain Research Institute, Niigata University
kn-affil=

affil-num=14
en-affil=Department of Neurology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=15
en-affil=Department of Neurology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=16
en-affil=Department of Neurology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=17
en-affil=Department of Neurology, Kyoto University Graduate School of Medicine
kn-affil=

affil-num=18
en-affil=Department of Human Health Sciences, Kyoto University Graduate School of Medicine
kn-affil=

affil-num=19
en-affil=Department of Neurology, Kyoto University Graduate School of Medicine
kn-affil=

affil-num=20
en-affil=Department of Neurology, Kyoto University Graduate School of Medicine
kn-affil=

affil-num=21
en-affil=Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
kn-affil=

affil-num=22
en-affil=Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
kn-affil=

affil-num=23
en-affil=Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
kn-affil=

affil-num=24
en-affil=Division of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University
kn-affil=

affil-num=25
en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry
kn-affil=

affil-num=26
en-affil=Department of Neurology, Okayama University Graduate School of Medicine and Dentistry
kn-affil=

affil-num=27
en-affil=Department of Neurology and Geriatrics, Graduate School of Medical and Dental Sciences, Kagoshima University
kn-affil=

affil-num=28
en-affil=Department of Neurology and Geriatrics, Graduate School of Medical and Dental Sciences, Kagoshima University
kn-affil=

affil-num=29
en-affil=Department of Neurology, Graduate School of Medical Sciences, Kyushu University
kn-affil=

affil-num=30
en-affil=Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
kn-affil=

affil-num=31
en-affil=Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
kn-affil=

affil-num=32
en-affil=Department of Neurology, Higashi-Saitama National Hospital
kn-affil=

affil-num=33
en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University
kn-affil=

affil-num=34
en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University
kn-affil=

affil-num=35
en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University
kn-affil=

affil-num=36
en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University
kn-affil=

affil-num=37
en-affil=Department of Neurology and Neurological Science, Tokyo Medical and Dental University
kn-affil=

affil-num=38
en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo
kn-affil=
en-keyword=multicenter cohort study
kn-keyword=multicenter cohort study
en-keyword=multiple system atrophy
kn-keyword=multiple system atrophy
en-keyword=natural history
kn-keyword=natural history
en-keyword=patient registry
kn-keyword=patient registry
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=7
article-no=
start-page=002114
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250725
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses from the Plant Viruses Subcommittee, 2025
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In March 2025, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote, newly proposed taxa were added to those under the mandate of the Plant Viruses Subcommittee. In brief, 1 new order, 3 new families, 6 new genera, 2 new subgenera and 206 new species were created. Some taxa were reorganized. Genus Cytorhabdovirus in the family Rhabdoviridae was abolished and its taxa were redistributed into three new genera Alphacytorhabdovirus, Betacytorhabdovirus and Gammacytorhabdovirus. Genus Waikavirus in the family Secoviridae was reorganized into two subgenera (Actinidivirus and Ritunrivirus). One family and four previously unaffiliated genera were moved to the newly established order Tombendovirales. Twelve species not assigned to a genus were abolished. To comply with the ICTV mandate of a binomial format for virus species, eight species were renamed. Demarcation criteria in the absence of biological information were defined in the genus Ilarvirus (family Bromoviridae). This article presents the updated taxonomy put forth by the Plant Viruses Subcommittee and ratified by the ICTV.
en-copyright=
kn-copyright=

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en-aut-name=ZhangSong
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kn-aut-name=
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affil-num=1
en-affil=Istituto per la Protezione Sostenibile delle Piante, CNR
kn-affil=

affil-num=2
en-affil=USDA-ARS, BARC, National Germplasm Resources Laboratory
kn-affil=

affil-num=3
en-affil=Liaoning Key Laboratory of Urban Integrated Pest Management and Ecological Security, Shenyang University
kn-affil=

affil-num=4
en-affil=Centro de Edafolog?a y Biolog?a Aplicada del Segura-CSIC
kn-affil=

affil-num=5
en-affil=Department of Molecular and Structural Biochemistry, North Carolina State University
kn-affil=

affil-num=6
en-affil=Unidad de Fitopatolog?a y Modelizaci?n Agr?cola (UFYMA) INTA-CONICET
kn-affil=

affil-num=7
en-affil=Plant Protection Department
kn-affil=

affil-num=8
en-affil=UMR 1332 Biologie du Fruit et Pathologie, University of Bordeaux, INRAE
kn-affil=

affil-num=9
en-affil=Margarita Salas Center for Biological Research (CIB-CSIC) Spanish Council for Scientific Research (CSIC)
kn-affil=

affil-num=10
en-affil=National Citrus Engineering and Technology Research Center, Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University
kn-affil=

affil-num=11
en-affil=Department of Plant Sciences, University of Cambridge
kn-affil=

affil-num=12
en-affil=Agriculture and Life Sciences Research Institute, Kangwon National University
kn-affil=

affil-num=13
en-affil=Agriculture Victoria Research, Department of Energy, Environment and Climate Action and School of Applied Systems Biology, La Trobe University
kn-affil=

affil-num=14
en-affil=University of Delhi South Campu
kn-affil=

affil-num=15
en-affil=Unidad de Fitopatolog?a y Modelizaci?n Agr?cola (UFYMA) INTA-CONICET
kn-affil=

affil-num=16
en-affil=Queensland Alliance for Agriculture and Food Innovation, The University of Queensland
kn-affil=

affil-num=17
en-affil=CIHEAM, Istituto Agronomico Mediterraneo of Bari
kn-affil=

affil-num=18
en-affil=Centro de Edafolog?a y Biolog?a Aplicada del Segura-CSIC
kn-affil=

affil-num=19
en-affil=CIHEAM, Istituto Agronomico Mediterraneo of Bari
kn-affil=

affil-num=20
en-affil=Virus South Data
kn-affil=

affil-num=21
en-affil=Queensland Department of Primary Industries
kn-affil=

affil-num=22
en-affil=Max Planck Institute for Marine Microbiology
kn-affil=

affil-num=23
en-affil=Plant Protection Department
kn-affil=

affil-num=24
en-affil=Fera Science Ltd (Fera), York Biotech Campus
kn-affil=

affil-num=25
en-affil=Embrapa Cassava and Fruits, Brazilian Agricultural Research Corporation
kn-affil=

affil-num=26
en-affil=Plant Pathology, Cornell University
kn-affil=

affil-num=27
en-affil=Queensland Alliance for Agriculture and Food Innovation, The University of Queensland
kn-affil=

affil-num=28
en-affil=Department of Biology, University of Oxford
kn-affil=

affil-num=29
en-affil=Swedish University of Agriculture
kn-affil=

affil-num=30
en-affil=USDA-ARS, USNA, Floral and Nursery Plants Research Unit
kn-affil=

affil-num=31
en-affil=USDA-ARS, BARC, Molecular Plant Pathology Laboratory
kn-affil=

affil-num=32
en-affil=Institute of Plant Protection-NRI
kn-affil=

affil-num=33
en-affil=PHIM Plant Health Institute, University of Montpellier, INRAE, CIRAD, IRD, Institute Agro
kn-affil=

affil-num=34
en-affil=Instituto de Biolog?a Molecular y Celular de Plantas (IBMCP), Universitat Polit?cnica de Valencia-CSIC
kn-affil=

affil-num=35
en-affil=Institut Fran?ais de la Vigne et du Vin
kn-affil=

affil-num=36
en-affil=Vali-e-Asr University of Rafsanjan, Department of Plant Protection
kn-affil=

affil-num=37
en-affil=Retired from John Innes Centre
kn-affil=

affil-num=38
en-affil=Embrapa Hortali?as
kn-affil=

affil-num=39
en-affil=USDA-ARS, USNA, Floral and Nursery Plants Research Unit
kn-affil=

affil-num=40
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=41
en-affil=International Potato Center (CIP)
kn-affil=

affil-num=42
en-affil=Institut Pasteur, Universit? Paris Cit?, CNRS UMR6047, Archaeal Virology Unit
kn-affil=

affil-num=43
en-affil=Institute for Plant Protection, NARO
kn-affil=

affil-num=44
en-affil=Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health
kn-affil=

affil-num=45
en-affil=Department of Biological Sciences, University of Toledo
kn-affil=

affil-num=46
en-affil=CIRAD, UMR PVBMT
kn-affil=

affil-num=47
en-affil=Liaoning Key Laboratory of Urban Integrated Pest Management and Ecological Security, Shenyang University
kn-affil=

affil-num=48
en-affil=State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University
kn-affil=

affil-num=49
en-affil=Institute of Plant Virology, Ningbo University
kn-affil=

affil-num=50
en-affil=Instituto de Patolog?a Vegetal (IPAVE), INTA, Unidad de Fitopatolog?a y Modelizaci?n Agr?cola (UFYMA) INTA-CONICET
kn-affil=

affil-num=51
en-affil=Centre for Research in Agricultural Genomics, CRAG (CSIC-IRTA-UAB-UB)
kn-affil=

affil-num=52
en-affil=UMR 1332 Biologie du Fruit et Pathologie, University of Bordeaux, INRAE
kn-affil=

affil-num=53
en-affil=Department of Agricultural Sciences, University of Helsinki
kn-affil=

affil-num=54
en-affil=Institute of Infectious Disease and Molecular Medicine, University of Cape Town
kn-affil=

affil-num=55
en-affil=Plant Pathology Laboratory, TERRA Gembloux Agro-Bio Tech, University of Liege
kn-affil=

affil-num=56
en-affil=Department of Plant Pathology, Entomology and Microbiology, Iowa State University
kn-affil=

affil-num=57
en-affil=Department of Plant Protection, Gorgan University of Agricultural Sciences and Natural Resources
kn-affil=

affil-num=58
en-affil=USDA-APHIS, Plant Protection and Quarantine
kn-affil=

affil-num=59
en-affil=CIRAD, AGAP Institut; AGAP Institut, University of Montpellier; CIRAD, INRAE
kn-affil=

affil-num=60
en-affil=Instituto de Ci?ncias Biol?gicas, Universidade de Bras?lia
kn-affil=

affil-num=61
en-affil=Instituto de Hortofruticultura Subtropical y Mediterr?nea �gLa Mayora�h (IHSM-UMA-CSIC), Consejo Superior de Investigaciones Cient?ficas
kn-affil=

affil-num=62
en-affil=Utsunomiya University
kn-affil=

affil-num=63
en-affil=Oklahoma State University, Institute for Biosecurity & Microbial Forensics
kn-affil=

affil-num=64
en-affil=Saga University
kn-affil=

affil-num=65
en-affil=Instituto de Biolog?a Molecular y Celular de Plantas (IBMCP), Universitat Polit?cnica de Valencia-CSIC
kn-affil=

affil-num=66
en-affil=Department of Plant Pathology, Washington State University
kn-affil=

affil-num=67
en-affil=Institute of Plant Molecular Biology
kn-affil=

affil-num=68
en-affil=PHIM Plant Health Institute, University of Montpellier, INRAE, CIRAD, IRD
kn-affil=

affil-num=69
en-affil=Istituto per la Protezione Sostenibile delle Piante, CNR
kn-affil=

affil-num=70
en-affil=Applied Molecular Biology Laboratory, Instituto Biol?gico de S?o Paulo
kn-affil=

affil-num=71
en-affil=Embrapa Recursos Gen?ticos e Biotecnologia
kn-affil=

affil-num=72
en-affil=Julius K?hn Institute, Federal Research Centre for Cultivated Plants, Institute for Epidemiology and Pathogen Diagnostics
kn-affil=

affil-num=73
en-affil=CIRAD, UMR PHIM
kn-affil=

affil-num=74
en-affil=USDA-ARS, BARC, Molecular Plant Pathology Laboratory, Beltsville, MD, USA
kn-affil=

affil-num=75
en-affil=Department of Agricultural Science and Plant Protection, Mississippi State University
kn-affil=

affil-num=76
en-affil=Department of Cell Biology and Genetics, Faculty of Science, Palack? University Olomouc
kn-affil=

affil-num=77
en-affil=Istituto per la Protezione Sostenibile delle Piante, CNR
kn-affil=

affil-num=78
en-affil=Summerland Research and Development Centre, Agriculture and Agri-Food Canada
kn-affil=

affil-num=79
en-affil=Department of Chemistry and Biotechnology, Tallinn University of Technology
kn-affil=

affil-num=80
en-affil=Strategic Planning Headquarters, NARO
kn-affil=

affil-num=81
en-affil=Department of Plant Pathology, Ecology and Evolution, Oklahoma State University
kn-affil=

affil-num=82
en-affil=Molecular Plant Pathology, University of Amsterdam
kn-affil=

affil-num=83
en-affil=Natural Resources Institute, University of Greenwich
kn-affil=

affil-num=84
en-affil=Kochi Agricultural Research Center
kn-affil=

affil-num=85
en-affil=Department of Chemistry and Biotechnology, Tallinn University of Technology
kn-affil=

affil-num=86
en-affil=Istituto per la Protezione Sostenibile delle Piante, CNR
kn-affil=

affil-num=87
en-affil=Currently unaffiliated
kn-affil=

affil-num=88
en-affil=CIRAD, UMR PVBMT & UMR PVBMT, Universit? de la R?union
kn-affil=

affil-num=89
en-affil=Queensland Alliance for Agriculture and Food Innovation, The University of Queensland
kn-affil=

affil-num=90
en-affil=Plant Health and Environment Laboratory
kn-affil=

affil-num=91
en-affil=Council for Agricultural Research and Economics, Research Centre for Plant Protection and Certification
kn-affil=

affil-num=92
en-affil=Institute for Plant Protection, NARO
kn-affil=

affil-num=93
en-affil=Department of Entomology and Plant Pathology, Division of Agriculture, University of Arkansas System
kn-affil=

affil-num=94
en-affil=INRAE, UR ASTRO
kn-affil=

affil-num=95
en-affil=PHIM Plant Health Institute, University of Montpellier, INRAE, CIRAD, IRD, Institute Agro
kn-affil=

affil-num=96
en-affil=Molecular Plant Pathology, University of Amsterdam
kn-affil=

affil-num=97
en-affil=Wageningen University and Research
kn-affil=

affil-num=98
en-affil=The Biodesign Center for Fundamental and Applied Microbiomics, Center for Evolution and Medicine, School of Life Sciences, Arizona State University
kn-affil=

affil-num=99
en-affil=Rijk Zwaan Breeding B.V.
kn-affil=

affil-num=100
en-affil=Department of Entomology and Plant Pathology, Division of Agriculture, University of Arkansas System
kn-affil=

affil-num=101
en-affil=Humboldt-Universit?t zu Berlin, Thaer-Institute of Agricultural and Horticultural Sciences
kn-affil=

affil-num=102
en-affil=The University of Queensland
kn-affil=

affil-num=103
en-affil=Dienstleistungszentrum L?ndlicher Raum Rheinpfalz
kn-affil=

affil-num=104
en-affil=North Carolina State University
kn-affil=

affil-num=105
en-affil=Food Futures Institute, Murdoch University
kn-affil=

affil-num=106
en-affil=Liaoning Key Laboratory of Urban Integrated Pest Management and Ecological Security, Shenyang University
kn-affil=

affil-num=107
en-affil=Dep. de Fitopatologia/BIOAGRO, Universidade Federal de Vi?osa
kn-affil=

affil-num=108
en-affil=National Citrus Engineering and Technology Research Center, Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=301
cd-vols=
no-issue=7
article-no=
start-page=110291
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A repertoire of visible light?sensitive opsins in the deep-sea hydrothermal vent shrimp Rimicaris hybisae
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Unlike terrestrial environments, where humans reside, there is no sunlight in the deep sea. Instead, dim visible light from black-body radiation and bioluminescence illuminates hydrothermal vent areas in the deep sea. A deep-sea hydrothermal vent shrimp, Rimicaris hybisae, is thought to detect this dim light using its enlarged dorsal eye; however, the molecular basis of its photoreception remains unexplored. Here, we characterized the molecular properties of opsins, universal photoreceptive proteins in animals, found in R. hybisae. Transcriptomic analysis identified six opsins: three Gq-coupled opsins, one Opn3, one Opn5, and one peropsin. Functional analysis revealed that five of these opsins exhibited light-dependent G protein activity, whereas peropsin exhibited the ability to convert all-trans-retinal to 11-cis-retinal like photoisomerases. Notably, all the R. hybisae opsins, including Opn5, convergently show visible light sensitivity (around 457?517 nm), whereas most opsins categorized as Opn5 have been demonstrated to be UV sensitive. Mutational analysis revealed that the unique visible light sensitivity of R. hybisae Opn5 is achieved through the stabilization of a protonated Schiff base by a counterion residue at position 83 (Asp83), which differs from the position identified in other opsins. These findings suggest that the vent shrimp R. hybisae has adapted its photoreceptive devices to dim deep-sea hydrothermal light by selectively maintaining a repertoire of visible light?sensitive opsins, including the uniquely tuned Opn5.
en-copyright=
kn-copyright=

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affil-num=1
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kn-affil=

affil-num=2
en-affil=Institute for Extra-Cutting-Edge Science and Technology Avant-Garde Research (X-Star), Japan Agency for Marine-Earth Science and Technology (JAMSTEC)
kn-affil=

affil-num=3
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Research Center for Bioscience and Nanoscience (CeBN), Research Institute for Marine Resources Utilization, Japan Agency for Marine-Earth Science and Technology (JAMSTEC)
kn-affil=

affil-num=5
en-affil=School of Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=School of Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Atmosphere and Ocean Research Institute, The University of Tokyo
kn-affil=

affil-num=8
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Biology, Graduate School of Science, Kobe University
kn-affil=

affil-num=10
en-affil=Department of Biology, Graduate School of Science, Kobe University
kn-affil=

affil-num=11
en-affil=Institute for Extra-Cutting-Edge Science and Technology Avant-Garde Research (X-Star), Japan Agency for Marine-Earth Science and Technology (JAMSTEC)
kn-affil=

affil-num=12
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Biophysics, Graduate School of Science, Kyoto University
kn-affil=

affil-num=14
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=15
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=rhodopsin
kn-keyword=rhodopsin
en-keyword=opsin
kn-keyword=opsin
en-keyword=G protein?coupled receptor
kn-keyword=G protein?coupled receptor
en-keyword=signal transduction
kn-keyword=signal transduction
en-keyword=photoreceptor
kn-keyword=photoreceptor
en-keyword=vision
kn-keyword=vision
en-keyword=photobiology
kn-keyword=photobiology
en-keyword=vent shrimp
kn-keyword=vent shrimp
en-keyword=deep sea
kn-keyword=deep sea
en-keyword=molecular evolution
kn-keyword=molecular evolution
END

start-ver=1.4
cd-journal=joma
no-vol=2024
cd-vols=
no-issue=12
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Multi-dimensional optimisation of the scanning strategy for the LiteBIRD space mission
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Large angular scale surveys in the absence of atmosphere are essential for measuring the primordial B-mode power spectrum of the Cosmic Microwave Background (CMB). Since this proposed measurement is about three to four orders of magnitude fainter than the temperature anisotropies of the CMB, in-flight calibration of the instruments and active suppression of systematic effects are crucial. We investigate the effect of changing the parameters of the scanning strategy on the in-flight calibration effectiveness, the suppression of the systematic effects themselves, and the ability to distinguish systematic effects by null-tests. Next-generation missions such as LiteBIRD, modulated by a Half-Wave Plate (HWP), will be able to observe polarisation using a single detector, eliminating the need to combine several detectors to measure polarisation, as done in many previous experiments and hence avoiding the consequent systematic effects. While the HWP is expected to suppress many systematic effects, some of them will remain. We use an analytical approach to comprehensively address the mitigation of these systematic effects and identify the characteristics of scanning strategies that are the most effective for implementing a variety of calibration strategies in the multi-dimensional space of common spacecraft scan parameters. We verify that LiteBIRD's standard configuration yields good performance on the metrics we studied. We also present Falcons.jl, a fast spacecraft scanning simulator that we developed to investigate this scanning parameter space.
en-copyright=
kn-copyright=

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en-aut-name=SakuraiY.
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aut-affil-num=91
ORCID=

en-aut-name=ScottD.
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en-aut-name=SekimotoY.
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kn-aut-mei=
aut-affil-num=93
ORCID=

en-aut-name=ShiraishiM.
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kn-aut-mei=
aut-affil-num=94
ORCID=

en-aut-name=SignorelliG.
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kn-aut-mei=
aut-affil-num=95
ORCID=

en-aut-name=SullivanR.M.
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kn-aut-mei=
aut-affil-num=96
ORCID=

en-aut-name=TakakuraH.
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=97
ORCID=

en-aut-name=TerenziL.
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=98
ORCID=

en-aut-name=TomasiM.
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kn-aut-mei=
aut-affil-num=99
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en-aut-name=TristramM.
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kn-aut-mei=
aut-affil-num=100
ORCID=

en-aut-name=van TentB.
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=101
ORCID=

en-aut-name=VielvaP.
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en-aut-mei=P.
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=102
ORCID=

en-aut-name=WehusI.K.
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kn-aut-sei=
kn-aut-mei=
aut-affil-num=103
ORCID=

en-aut-name=WestbrookB.
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kn-aut-mei=
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ORCID=

en-aut-name=Weymann-DespresG.
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kn-aut-mei=
aut-affil-num=105
ORCID=

en-aut-name=WollackE.J.
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kn-aut-mei=
aut-affil-num=106
ORCID=

en-aut-name=ZannoniM.
en-aut-sei=Zannoni
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=107
ORCID=

en-aut-name=ZhouY.
en-aut-sei=Zhou
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=108
ORCID=

affil-num=1
en-affil=Okayama University, Department of Physics
kn-affil=

affil-num=2
en-affil=International School for Advanced Studies (SISSA)
kn-affil=

affil-num=3
en-affil=Okayama University, Department of Physics
kn-affil=

affil-num=4
en-affil=ILANCE, CNRS, University of Tokyo International Research Laboratory
kn-affil=

affil-num=5
en-affil=IRAP, Universit? de Toulouse, CNRS, CNES, UPS
kn-affil=

affil-num=6
en-affil=Okayama University, Department of Physics
kn-affil=

affil-num=7
en-affil=Okayama University, Department of Physics
kn-affil=

affil-num=8
en-affil=Okayama University, Department of Physics
kn-affil=

affil-num=9
en-affil=Universit? Paris Cit?, CNRS, Astroparticule et Cosmologie
kn-affil=

affil-num=10
en-affil=IRAP, Universit? de Toulouse, CNRS, CNES, UPS
kn-affil=

affil-num=11
en-affil=The University of Tokyo, Department of Physics
kn-affil=

affil-num=12
en-affil=Dipartimento di Fisica, Universit? di Roma Tor Vergata
kn-affil=

affil-num=13
en-affil=International School for Advanced Studies (SISSA)
kn-affil=

affil-num=14
en-affil=Dipartimento di Fisica e Scienze della Terra, Universit? di Ferrara
kn-affil=

affil-num=15
en-affil=IRAP, Universit? de Toulouse, CNRS, CNES, UPS
kn-affil=

affil-num=16
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=

affil-num=17
en-affil=Dipartimento di Fisica e Astronomia "G. Galilei", Universit? degli Studi di Padova
kn-affil=

affil-num=18
en-affil=School of Physics, Indian Institute of Science Education and Research Thiruvananthapuram
kn-affil=

affil-num=19
en-affil=Dipartimento di Fisica, Universit? degli Studi di Milano
kn-affil=

affil-num=20
en-affil=Dipartimento di Fisica e Scienze della Terra, Universit? di Ferrara
kn-affil=

affil-num=21
en-affil=Dipartimento di Fisica e Scienze della Terra, Universit? di Ferrara
kn-affil=

affil-num=22
en-affil=School of Physics and Astronomy, Cardiff University
kn-affil=

affil-num=23
en-affil=INFN Sezione di Ferrara
kn-affil=

affil-num=24
en-affil=IRAP, Universit? de Toulouse, CNRS, CNES, UPS
kn-affil=

affil-num=25
en-affil=International School for Advanced Studies (SISSA)
kn-affil=

affil-num=26
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=

affil-num=27
en-affil=Jodrell Bank Centre for Astrophysics, Department of Physics and Astronomy, School of Natural Sciences, The University of Manchester
kn-affil=

affil-num=28
en-affil=Centre Spatial de Li?ge, Universit? de Li?ge
kn-affil=

affil-num=29
en-affil=Dipartimento di Fisica, Universit? La Sapienza
kn-affil=

affil-num=30
en-affil=Dipartimento di Fisica, Universit? La Sapienza
kn-affil=

affil-num=31
en-affil=INAF, OAS Bologna
kn-affil=

affil-num=32
en-affil=Dipartimento di Fisica, Universit? La Sapienza
kn-affil=

affil-num=33
en-affil=Dipartimento di Fisica, Universit? La Sapienza
kn-affil=

affil-num=34
en-affil=Institute of Particle and Nuclear Studies (IPNS), High Energy Accelerator Research Organization (KEK)
kn-affil=

affil-num=35
en-affil=CNRS-UCB International Research Laboratory, Centre Pierre Bin?truy, UMI2007
kn-affil=

affil-num=36
en-affil=INFN Sezione Milano Bicocca
kn-affil=

affil-num=37
en-affil=Max Planck Institute for Astrophysics
kn-affil=

affil-num=38
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=

affil-num=39
en-affil=Universit? Paris Cit?, CNRS, Astroparticule et Cosmologie
kn-affil=

affil-num=40
en-affil=INAF, OAS Bologna
kn-affil=

affil-num=41
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=

affil-num=42
en-affil=Dipartimento di Fisica e Scienze della Terra, Universit? di Ferrara
kn-affil=

affil-num=43
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=

affil-num=44
en-affil=University of Milano Bicocca, Physics Department
kn-affil=

affil-num=45
en-affil=International Center for Quantum-field Measurement Systems for Studies of the Universe and Particles (QUP), High Energy Accelerator Research Organization (KEK)
kn-affil=

affil-num=46
en-affil=School of Physics and Astronomy, Cardiff University
kn-affil=

affil-num=47
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=

affil-num=48
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=

affil-num=49
en-affil=Instituto de Astrof?sica de Canarias
kn-affil=

affil-num=50
en-affil=INAF, OAS Bologna
kn-affil=

affil-num=51
en-affil=International Center for Quantum-field Measurement Systems for Studies of the Universe and Particles (QUP), High Energy Accelerator Research Organization (KEK)
kn-affil=

affil-num=52
en-affil=Universit? Paris-Saclay, CNRS/IN2P3, IJCLab
kn-affil=

affil-num=53
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=

affil-num=54
en-affil=Okayama University, Department of Physics
kn-affil=

affil-num=55
en-affil=Institute of Particle and Nuclear Studies (IPNS), High Energy Accelerator Research Organization (KEK)
kn-affil=

affil-num=56
en-affil=Dipartimento di Fisica, Universit? La Sapienza
kn-affil=

affil-num=57
en-affil=INFN Sezione di Ferrara
kn-affil=

affil-num=58
en-affil=Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), UTIAS, The University of Tokyo
kn-affil=

affil-num=59
en-affil=Dipartimento di Fisica e Scienze della Terra, Universit? di Ferrara
kn-affil=

affil-num=60
en-affil=Laboratoire de Physique de l'?cole Normale Sup?rieure, ENS, Universit? PSL, CNRS, Sorbonne Universit?, Universit? de Paris
kn-affil=

affil-num=61
en-affil=University of California, San Diego, Department of Physics
kn-affil=

affil-num=62
en-affil=Aurora Technology for the European Space Agency
kn-affil=

affil-num=63
en-affil=Space Science Data Center, Italian Space Agency
kn-affil=

affil-num=64
en-affil=Universit? Paris-Saclay, CNRS, Institut d'Astrophysique Spatiale
kn-affil=

affil-num=65
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=

affil-num=66
en-affil=Dipartimento di Fisica, Universit? La Sapienza
kn-affil=

affil-num=67
en-affil=Dipartimento di Fisica e Astronomia "G. Galilei", Universit? degli Studi di Padova
kn-affil=

affil-num=68
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=

affil-num=69
en-affil=Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), UTIAS, The University of Tokyo
kn-affil=

affil-num=70
en-affil=Dipartimento di Fisica, Universit? La Sapienza
kn-affil=

affil-num=71
en-affil=Dipartimento di Fisica, Universit? di Roma Tor Vergata
kn-affil=

affil-num=72
en-affil=Max Planck Institute for Astrophysics
kn-affil=

affil-num=73
en-affil=INAF, OAS Bologna
kn-affil=

affil-num=74
en-affil=IRAP, Universit? de Toulouse, CNRS, CNES, UPS
kn-affil=

affil-num=75
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=

affil-num=76
en-affil=Kavli Institute for the Physics and Mathematics of the Universe (Kavli IPMU, WPI), UTIAS, The University of Tokyo
kn-affil=

affil-num=77
en-affil=Dipartimento di Fisica, Universit? La Sapienza
kn-affil=

affil-num=78
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=

affil-num=79
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=

affil-num=80
en-affil=Okayama University, Department of Physics
kn-affil=

affil-num=81
en-affil=Dipartimento di Fisica e Scienze della Terra, Universit? di Ferrara
kn-affil=

affil-num=82
en-affil=INAF, OAS Bologna
kn-affil=

affil-num=83
en-affil=Dipartimento di Fisica, Universit? La Sapienza
kn-affil=

affil-num=84
en-affil=INFN Sezione di Pisa
kn-affil=

affil-num=85
en-affil=Space Science Data Center, Italian Space Agency
kn-affil=

affil-num=86
en-affil=Istituto Nazionale di Fisica Nucleare-aboratori Nazionali di Frascati (INFN-LNF)
kn-affil=

affil-num=87
en-affil=Dipartimento di Fisica e Scienze della Terra, Universit? di Ferrara
kn-affil=

affil-num=88
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=

affil-num=89
en-affil=Dipartimento di Fisica, Universit? di Roma Tor Vergata
kn-affil=

affil-num=90
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=

affil-num=91
en-affil=Suwa University of Science
kn-affil=

affil-num=92
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=

affil-num=93
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=

affil-num=94
en-affil=Suwa University of Science
kn-affil=

affil-num=95
en-affil=Dipartimento di Fisica, Universit? di Pisa
kn-affil=

affil-num=96
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=

affil-num=97
en-affil=Japan Aerospace Exploration Agency (JAXA), Institute of Space and Astronautical Science (ISAS)
kn-affil=

affil-num=98
en-affil=INAF, OAS Bologna
kn-affil=

affil-num=99
en-affil=Dipartimento di Fisica, Universit? degli Studi di Milano
kn-affil=

affil-num=100
en-affil=Universit? Paris-Saclay, CNRS/IN2P3, IJCLab
kn-affil=

affil-num=101
en-affil=Universit? Paris-Saclay, CNRS/IN2P3, IJCLab
kn-affil=

affil-num=102
en-affil=Instituto de Fisica de Cantabria (IFCA, CSIC-UC)
kn-affil=

affil-num=103
en-affil=Institute of Theoretical Astrophysics, University of Oslo
kn-affil=

affil-num=104
en-affil=University of California, Berkeley, Department of Physics, Berkeley
kn-affil=

affil-num=105
en-affil=Universit? Paris-Saclay, CNRS/IN2P3, IJCLab
kn-affil=

affil-num=106
en-affil=NASA Goddard Space Flight Center
kn-affil=

affil-num=107
en-affil=University of Milano Bicocca, Physics Department
kn-affil=

affil-num=108
en-affil=International Center for Quantum-field Measurement Systems for Studies of the Universe and Particles (QUP), High Energy Accelerator Research Organization (KEK)
kn-affil=
en-keyword=CMBR experiments
kn-keyword=CMBR experiments
en-keyword=CMBR polarisation
kn-keyword=CMBR polarisation
en-keyword=gravitational waves and CMBR polarization
kn-keyword=gravitational waves and CMBR polarization
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=6
article-no=
start-page=459
end-page=464
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Traumatic Neuroma Arising from Surgical Trauma during Conversion from Laparoscopic to Open Cholecystectomy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Traumatic neuroma is an abnormal proliferation of injured nerves resulting from trauma or surgery. We present a case of traumatic neuroma arising in the cystic duct after cholecystectomy. A 66-year-old man was referred to our department due to a biliary tumor. He had undergone cholecystectomy 20 years prior. Cholangioscopy showed an elevated lesion covered with smooth mucosa. Histological examination revealed normal bile duct mucosa. Although benign disease was suspected, the possibilities of malignant disease could not be excluded. Extrahepatic bile duct resection was planned to include intraoperative rapid-freezing of a biopsy specimen followed by histopathological examination. These intraoperative histology results showed proliferation of nerve and fibrous tissue only, resulting in the diagnosis of traumatic neuroma, so no lymph nodes were removed. To avoid excessive surgical intervention, histopathological examination of an intraoperative rapid-frozen biopsy specimen may be important for diagnosing traumatic neuroma.
en-copyright=
kn-copyright=

en-aut-name=SakamotoShinya
en-aut-sei=Sakamoto
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TabuchiMotoyasu
en-aut-sei=Tabuchi
en-aut-mei=Motoyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YoshimatsuRika
en-aut-sei=Yoshimatsu
en-aut-mei=Rika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsumotoManabu
en-aut-sei=Matsumoto
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IwataJun
en-aut-sei=Iwata
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkabayashiTakehiro
en-aut-sei=Okabayashi
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=

affil-num=3
en-affil=Department of Radiology, Kochi Health Sciences Center
kn-affil=

affil-num=4
en-affil=Department of Diagnostic Pathology, Kochi Health Sciences Center
kn-affil=

affil-num=5
en-affil=Department of Diagnostic Pathology, Kochi Health Sciences Center
kn-affil=

affil-num=6
en-affil=Department of Gastroenterological Surgery, Kochi Health Sciences Center
kn-affil=
en-keyword=traumatic neuroma
kn-keyword=traumatic neuroma
en-keyword=biliary stricture
kn-keyword=biliary stricture
en-keyword=cholecystectomy
kn-keyword=cholecystectomy
en-keyword=cholangiography
kn-keyword=cholangiography
en-keyword=intraoperative rapid-frozen biopsy
kn-keyword=intraoperative rapid-frozen biopsy
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=6
article-no=
start-page=453
end-page=458
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202412
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Case of Radiation-Induced Angiosarcoma after Breast-Conserving Surgery with Hypofractionated Radiotherapy in a Japanese Patient
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Radiation-induced angiosarcoma (RIAS) is a rare, late adverse event of radiotherapy comprising approximately half of all radiation-induced sarcomas. It has a relatively short latency period and generally unfavorable prognosis. This study presents a case of RIAS that developed 5 years and 11 months after the completion of hypofractionated radiotherapy (42.56 Gy/16 fractions) following partial mastectomy. The patient was diagnosed with RIAS 10 months after the onset of skin redness. She underwent skin tumor resection, followed by paclitaxel, then pazopanib administration, but no radiotherapy. At 6 years and 2 months after surgery, no RIAS recurrence has been detected.
en-copyright=
kn-copyright=

en-aut-name=KawataYujiro
en-aut-sei=Kawata
en-aut-mei=Yujiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeKenta
en-aut-sei=Watanabe
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TokiyaRyoji
en-aut-sei=Tokiya
en-aut-mei=Ryoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsunoTakeshi
en-aut-sei=Matsuno
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TanakaRyo
en-aut-sei=Tanaka
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TairaNaruto
en-aut-sei=Taira
en-aut-mei=Naruto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KatsuiKuniaki
en-aut-sei=Katsui
en-aut-mei=Kuniaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Radiology, Kawasaki Medical School
kn-affil=

affil-num=2
en-affil=Department of Radiology, Kawasaki Medical School
kn-affil=

affil-num=3
en-affil=Department of Radiology, Kawasaki Medical School
kn-affil=

affil-num=4
en-affil=Department of Pathology, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of Dermatology, Kawasaki Medical School
kn-affil=

affil-num=6
en-affil=Department of Breast and Thyroid Surgery, Kawasaki Medical School
kn-affil=

affil-num=7
en-affil=Department of Radiology, Kawasaki Medical School
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=hypofractionated radiotherapy
kn-keyword=hypofractionated radiotherapy
en-keyword=radiation-induced angiosarcoma
kn-keyword=radiation-induced angiosarcoma
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ŒûŠW‚ÌŒ`�¬‚É‚¨‚¯‚éƒ�ƒJƒjƒJƒ‹ƒXƒgƒŒƒX‚̉e‹¿
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NAGATAMasayo
en-aut-sei=NAGATA
en-aut-mei=Masayo
kn-aut-name=‰i“c˜`‘ã
kn-aut-sei=‰i“c
kn-aut-mei=˜`‘ã
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=163
end-page=170
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Impact of Light Touch and Pin Prick on Functional Outcomes in Patients with Traumatic Spinal Cord Injury
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A spinal cord injury (SCI) can cause severe lifelong functional disability and profoundly affect an individual�fs daily life. We investigated the prediction of patients�f post-SCI functional outcomes by evaluating sensory scores rather than motor scores, as the latter�fs association with functional outcomes is well established. We examined patients�f responses to a light touch (LT) and pin prick (PP) at admission and the response data�fs usefulness as predictors of functional outcomes (i.e., ability to perform activities of daily living) at discharge. This exploratory observational study used data from the Japanese National Spinal Cord Injury Database (SCI-J). Data from 3,676 patients who met the inclusion criteria and were admitted for an SCI between 1997 and 2020 were analyzed. The motor score of the Functional Independence Measure (mFIM) at discharge was used as an index of functional outcome. A multiple regression analysis revealed that the mFIM was associated with both the LT response (ƒÀ=0.07 (0.01), p<0.001) and the PP response (ƒÀ=0.07 (0.01), p<0.001) at admission. The false discovery rate log-worth values for LT and PP were 6.6 and 8.5, respectively. Our findings demonstrate that LT and PP scores at admission can help predict patients�f functional outcomes after an SCI, although the magnitude of their contributions is not high.
en-copyright=
kn-copyright=

en-aut-name=DeguchiTakayuki
en-aut-sei=Deguchi
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KandaKanae
en-aut-sei=Kanda
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FurusawaKazunari
en-aut-sei=Furusawa
en-aut-mei=Kazunari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Nlandu Roger Ngatu
en-aut-sei=Nlandu Roger Ngatu
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HiraoTomohiro
en-aut-sei=Hirao
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Rehabilitation, Kagawa Rosai Hospital
kn-affil=

affil-num=2
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=3
en-affil=Department of Rehabilitation Medicine, Kibikogen Rehabilitation Center for Employment Injuries
kn-affil=

affil-num=4
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=

affil-num=5
en-affil=Department of Public Health, Faculty of Medicine, Kagawa University
kn-affil=
en-keyword=functional independence measure
kn-keyword=functional independence measure
en-keyword=light touch
kn-keyword=light touch
en-keyword=pin prick
kn-keyword=pin prick
en-keyword=spinal cord injury
kn-keyword=spinal cord injury
en-keyword=Japanese National Spinal Cord Injury Database
kn-keyword=Japanese National Spinal Cord Injury Database
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=151
end-page=161
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors�f growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
en-copyright=
kn-copyright=

en-aut-name=KomatsubaraTadashi
en-aut-sei=Komatsubara
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TazawaHiroshi
en-aut-sei=Tazawa
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HaseiJoe
en-aut-sei=Hasei
en-aut-mei=Joe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OmoriToshinori
en-aut-sei=Omori
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SugiuKazuhisa
en-aut-sei=Sugiu
en-aut-mei=Kazuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MochizukiYusuke
en-aut-sei=Mochizuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=DemiyaKoji
en-aut-sei=Demiya
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YoshidaAki
en-aut-sei=Yoshida
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KunisadaToshiyuki
en-aut-sei=Kunisada
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=UrataYasuo
en-aut-sei=Urata
en-aut-mei=Yasuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KagawaShunsuke
en-aut-sei=Kagawa
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Oncolys BioPharma, Inc.
kn-affil=

affil-num=12
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=soft-tissue sarcoma
kn-keyword=soft-tissue sarcoma
en-keyword=radiotherapy
kn-keyword=radiotherapy
en-keyword=oncolytic adenovirus
kn-keyword=oncolytic adenovirus
en-keyword=p53
kn-keyword=p53
en-keyword=BCL-xL
kn-keyword=BCL-xL
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=2
article-no=
start-page=95
end-page=106
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=202404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Roles of Neuropeptide Y in Respiratory Disease Pathogenesis via the Airway Immune Response
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The lungs are very complex organs, and the respiratory system performs the dual roles of repairing tissue while protecting against infection from various environmental stimuli. Persistent external irritation disrupts the immune responses of tissues and cells in the respiratory system, ultimately leading to respiratory disease. Neuropeptide Y (NPY) is a 36-amino-acid polypeptide and a neurotransmitter that regulates homeostasis. The NPY receptor is a seven-transmembrane-domain G-protein-coupled receptor with six subtypes (Y1, Y2, Y3, Y4, Y5, and Y6). Of these receptors, Y1, Y2, Y4, and Y5 are functional in humans, and Y1 plays important roles in the immune responses of many organs, including the respiratory system. NPY and the Y1 receptor have critical roles in the pathogenesis of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis. The effects of NPY on the airway immune response and pathogenesis differ among respiratory diseases. This review focuses on the involvement of NPY in the airway immune response and pathogenesis of various respiratory diseases.
en-copyright=
kn-copyright=

en-aut-name=ItanoJunko
en-aut-sei=Itano
en-aut-mei=Junko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyaharaNobuaki
en-aut-sei=Miyahara
en-aut-mei=Nobuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=
en-keyword=neuropeptide y
kn-keyword=neuropeptide y
en-keyword=Y1 receptor
kn-keyword=Y1 receptor
en-keyword=airway immune response
kn-keyword=airway immune response
en-keyword=bronchial epithelial cells
kn-keyword=bronchial epithelial cells
en-keyword=respiratory disease
kn-keyword=respiratory disease
END

start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=
article-no=
start-page=169
end-page=181
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Relationship between Social Networks and ISO15189 Accreditation
kn-title=ŽÐ‰ïƒlƒbƒgƒ��[ƒN‚ÆISO15189”F’èŽæ“¾‚Æ‚ÌŠÖ˜A
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NAGATAHiroyo
en-aut-sei=NAGATA
en-aut-mei=Hiroyo
kn-aut-name=‰i“cŒ[‘ã
kn-aut-sei=‰i“c
kn-aut-mei=Œ[‘ã
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=6
article-no=
start-page=635
end-page=645
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202312
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Nutritional Support Combined with Neuromuscular Electrical Stimulation on Muscle Strength and Thickness: A Randomized Controlled Trial in Healthy Young Adult Males
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted.
en-copyright=
kn-copyright=

en-aut-name=IkedaTomohiro
en-aut-sei=Ikeda
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkamuraKazunori
en-aut-sei=Okamura
en-aut-mei=Kazunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HasegawaMasaki
en-aut-sei=Hasegawa
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanakaSatoshi
en-aut-sei=Tanaka
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KanaiShusaku
en-aut-sei=Kanai
en-aut-mei=Shusaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Rehabilitation Medicine, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=

affil-num=3
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=

affil-num=4
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=

affil-num=5
en-affil=Department of Physical Therapy, Faculty of Health and Welfare, Prefectural University of Hiroshima
kn-affil=
en-keyword=whey protein
kn-keyword=whey protein
en-keyword=electrical stimulation
kn-keyword=electrical stimulation
en-keyword=muscle strength
kn-keyword=muscle strength
en-keyword=healthy volunteers
kn-keyword=healthy volunteers
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=10
article-no=
start-page=1035
end-page=1045
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220913
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evidence on percutaneous radiofrequency and microwave ablation for liver metastases over the last decade
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose�@This review aimed to summarize the treatment outcomes of percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA) for metastatic liver tumors based on the findings of published studies over the last decade.<br>
Materials and methods�@Literature describing the survival outcomes of ablation therapy for liver metastases was explored using the PubMed database on April 26, 2022, and articles published in 2012 or later were selected. The included studies met the following criteria: (i) English literature, (ii) original clinical studies, and (iii) literature describing overall survival (OS) of thermal ablation for metastatic liver tumors. All case reports and cohort studies with fewer than 20 patients and those that evaluated ablation for palliative purposes were excluded.<br>
Results�@RFA was the most commonly used method for ablation, while MWA was used in several recent studies. RFA and MWA for liver metastases from various primary tumors have been reported; however, majority of the studies focused on colorectal cancer. The local control rate by RFA and MWA varied widely among the studies, ranging approximately 50?90%. Five-year survival rates of 20?60% have been reported following ablation for colorectal liver metastases by a number of studies, and several reports of 10-year survival rates were also noted.<br>
Conclusion�@Comparative studies of local therapies for colorectal liver metastases demonstrated that RFA provides comparable survival outcomes to surgical metastasectomy and stereotactic body radiation therapy.
en-copyright=
kn-copyright=

en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawabataTakahiro
en-aut-sei=Kawabata
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MunetomoKazuaki
en-aut-sei=Munetomo
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NagataShoma
en-aut-sei=Nagata
en-aut-mei=Shoma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Ablation
kn-keyword=Ablation
en-keyword=Liver
kn-keyword=Liver
en-keyword=Metastasis
kn-keyword=Metastasis
END

start-ver=1.4
cd-journal=joma
no-vol=155
cd-vols=
no-issue=
article-no=
start-page=105797
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202311
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ruxolitinib altered IFN-ƒÀ induced necroptosis of human dental pulp stem cells during osteoblast differentiation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective: This study aimed to evaluate the role of ruxolitinib in the interferon beta (IFN-ƒÀ) mediated osteoblast differentiation using human dental pulp stem cells (hDPSCs).<br>
Design: hDPSCs from five deciduous teeth of healthy patients were stimulated by adding human recombinant IFN-ƒÀ protein (1 or 2 ng/ml) to the osteogenic differentiation induction medium. Substrate formation was determined using Alizarin Red staining, calcium concentration, and osteoblast marker expression levels. Ruxolitinib was used to inhibit the Janus kinase/signal transducers and activators of transcription (JAK-STAT) pathway. Apoptosis was detected using terminal deoxynucleotidyl nick-end labeling (TUNEL) staining, and necroptosis was detected using propidium iodide staining and phosphorylated mixed lineage kinase domain-like protein (pMLKL) expression.<br>
Results: In the IFN-ƒÀ-treated group, substrate formation was inhibited by a reduction in alkaline phosphatase (ALP) expression in a concentration-dependent manner. Although the proliferation potency was unchanged between the IFN-ƒÀ-treated and control groups, the cell number was significantly reduced in the experimental group. TUNEL-positive cell number was not significantly different; however, the protein level of necroptosis markers, interleukin-6 (IL-6) and pMLKL were significantly increased in the substrate formation. Cell number and ALP expression level were improved in the group administered ruxolitinib, a JAK-STAT inhibitor. Additionally, ruxolitinib significantly suppressed IL-6 and pMLKL levels.<br>
Conclusion: Ruxolitinib interfered with the IFN-ƒÀ-mediated necroptosis and osteogenic differentiation via the JAK-STAT pathway.
en-copyright=
kn-copyright=

en-aut-name=TanakaAtsuko
en-aut-sei=Tanaka
en-aut-mei=Atsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HayanoSatoru
en-aut-sei=Hayano
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NagataMasayo
en-aut-sei=Nagata
en-aut-mei=Masayo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KosamiTakahiro
en-aut-sei=Kosami
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WangZiyi
en-aut-sei=Wang
en-aut-mei=Ziyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Type-I interferon
kn-keyword=Type-I interferon
en-keyword=Janus kinase/signal transducers and activators of transcription pathway
kn-keyword=Janus kinase/signal transducers and activators of transcription pathway
en-keyword=Osteoblast
kn-keyword=Osteoblast
en-keyword=Necroptosis
kn-keyword=Necroptosis
en-keyword=Singleton-Merten Syndrome
kn-keyword=Singleton-Merten Syndrome
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=5
article-no=
start-page=545
end-page=552
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Endoscopic Manifestations and Clinical Characteristics of Localized Gastric Light-Chain Amyloidosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine the endoscopic and clinical features of localized gastric amyloid light-chain (AL) amyloidosis, we retrospectively examined the characteristics of nine patients (eight men and one woman) encountered by the hospitals in our network. Lesions were predominantly flat and depressed with surface vascular dilatation (n=5); others were characterized by subepithelial lesions (n=2), mucosal color change (n=1), and a mass-like morphology with swollen mucosal folds (n=1). Colonoscopy (n=7), video capsule enteroscopy (n=2), serum (n=5) and urine immunoelectrophoresis (n=4), and bone marrow examination (n=3) were performed to exclude involvement of organs other than the stomach. As treatment for gastric lesions of AL amyloidosis, one patient each underwent endoscopic submucosal dissection (n=1) and argon plasma coagulation (n=1), while the remaining seven patients underwent no specific treatment. During a mean follow-up of 4.2 years, one patient died 3.2 years after diagnosis, but the cause of death, which occurred in another hospital, was unknown. The remaining eight patients were alive at the last visit. In conclusion, although localized gastric AL amyloidosis can show various macroscopic features on esophagogastroduodenoscopy, flat, depressed lesions with vascular dilatation on the surface are predominant.
en-copyright=
kn-copyright=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TanakaShouichi
en-aut-sei=Tanaka
en-aut-mei=Shouichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ToyokawaTatsuya
en-aut-sei=Toyokawa
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NishimuraMamoru
en-aut-sei=Nishimura
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsuzukiTakao
en-aut-sei=Tsuzuki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyaharaKoji
en-aut-sei=Miyahara
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NegishiShin
en-aut-sei=Negishi
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OhyaShogen
en-aut-sei=Ohya
en-aut-mei=Shogen
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OtsukaMotoyuki
en-aut-sei=Otsuka
en-aut-mei=Motoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology, National Hospital Organization Iwakuni Clinical Center
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology, National Hospital Organization Fukuyama Medical Center
kn-affil=

affil-num=4
en-affil=Department of Internal Medicine, Okayama City Hospital
kn-affil=

affil-num=5
en-affil=Department of Internal Medicine, Japanese Red Cross Society Himeji Hospital
kn-affil=

affil-num=6
en-affil=Department of Internal Medicine, Hiroshima City Hiroshima Citizens Hospital
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=8
en-affil=Kawaguchi Medical Clinic
kn-affil=

affil-num=9
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=esophagogastroduodenoscopy
kn-keyword=esophagogastroduodenoscopy
en-keyword=gastric lesion
kn-keyword=gastric lesion
en-keyword=amyloidosis
kn-keyword=amyloidosis
en-keyword=light chain
kn-keyword=light chain
END

start-ver=1.4
cd-journal=joma
no-vol=40
cd-vols=
no-issue=10
article-no=
start-page=1024
end-page=1034
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220702
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Up-to-date evidence on image-guided thermal ablation for metastatic lung tumors: a review
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this review was to summarize the latest evidence on image-guided thermal ablation therapies for lung metastases. PubMed was used to search for relevant articles that reported the oncological outcomes of thermal ablation for metastatic lung tumors, and those published in 2010 or later were selected for review. Ablative therapies were applied for lung metastases from various types of primary tumors, but most commonly colorectal ones. Radiofrequency ablation (RFA) was the most evaluated technique, followed by microwave ablation (MWA). The local control rates of ablative therapies were generally favorable, approximately 80?90% in many studies. Representative studies demonstrated promising overall survival rates of approximately 50% or higher 5 years after ablation for lung metastases from colorectal cancer or mixed types of primary tumors. Nevertheless, the survival outcomes varied depending on the type of primary tumor and background factors of patients such as other metastases and comorbidities. Several studies had aimed to compare the outcomes of various ablative therapies such as RFA, MWA, and cryoablation; however, conclusive data are not yet available to determine the most appropriate ablation modality for lung metastases. Further data accumulation is needed, especially for long-term outcomes and comparisons with other therapies.
en-copyright=
kn-copyright=

en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawabataTakahiro
en-aut-sei=Kawabata
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MunetomoKazuaki
en-aut-sei=Munetomo
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NagataShoma
en-aut-sei=Nagata
en-aut-mei=Shoma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Radiological Technology, Faculty of Health Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Ablation
kn-keyword=Ablation
en-keyword=Lung
kn-keyword=Lung
en-keyword=Pulmonary
kn-keyword=Pulmonary
en-keyword=Metastasis
kn-keyword=Metastasis
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=1
article-no=
start-page=6974
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230428
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A blue-shifted anion channelrhodopsin from the Colpodellida alga Vitrella brassicaformis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Microbial rhodopsins, a family of photoreceptive membrane proteins containing the chromophore retinal, show a variety of light-dependent molecular functions. Channelrhodopsins work as light-gated ion channels and are widely utilized for optogenetics, which is a method for controlling neural activities by light. Since two cation channelrhodopsins were identified from the chlorophyte alga Chlamydomonas reinhardtii, recent advances in genomic research have revealed a wide variety of channelrhodopsins including anion channelrhodopsins (ACRs), describing their highly diversified molecular properties (e.g., spectral sensitivity, kinetics and ion selectivity). Here, we report two channelrhodopsin-like rhodopsins from the Colpodellida alga Vitrella brassicaformis, which are phylogenetically distinct from the known channelrhodopsins. Spectroscopic and electrophysiological analyses indicated that these rhodopsins are green- and blue-sensitive pigments (lambda(max) = similar to 550 and similar to 440 nm) that exhibit light-dependent ion channeling activities. Detailed electrophysiological analysis revealed that one of them works as a monovalent anion (Cl-, Br- and NO3-) channel and we named it V. brassicaformis anion channelrhodopsin-2, VbACR2. Importantly, the absorption maximum of VbACR2 (similar to 440 nm) is blue-shifted among the known ACRs. Thus, we identified the new blue-shifted ACR, which leads to the expansion of the molecular diversity of ACRs.
en-copyright=
kn-copyright=

en-aut-name=KojimaKeiichi
en-aut-sei=Kojima
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawanishiShiho
en-aut-sei=Kawanishi
en-aut-mei=Shiho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishimuraYosuke
en-aut-sei=Nishimura
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HasegawaMasumi
en-aut-sei=Hasegawa
en-aut-mei=Masumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakaoShin
en-aut-sei=Nakao
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NagataYuya
en-aut-sei=Nagata
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YoshizawaSusumu
en-aut-sei=Yoshizawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SudoYuki
en-aut-sei=Sudo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Research Center for Bioscience and Nanoscience (CeBN), Research Institute for  Marine Resources Utilization, Japan Agency for Marine-Earth Science and Technology (JAMSTEC)
kn-affil=

affil-num=4
en-affil=Institute for Extra?Cutting?Edge Science and Technology Avant?Garde Research (X?Star)
kn-affil=

affil-num=5
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Atmosphere and  Ocean Research Institute, The University of Tokyo
kn-affil=

affil-num=8
en-affil=Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=3
article-no=
start-page=235
end-page=241
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Endocrinological Changes after Anamorelin Administration in Patients with Gastrointestinal Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Changes in hormone levels in patients with cancer cachexia after anamorelin administration have not been fully investigated. This study aimed to determine how anamorelin affects the endocrine system in patients with gastrointestinal cancer and cachexia. We prospectively enrolled 13 patients and comprehensively investigated their body weight and levels of serum albumin, hemoglobin A1c (HbA1c), and hormones before (week 0) and 3 and 12 weeks after anamorelin administration. The variables were evaluated at week 3 in 9 patients and at week 12 in 5 patients. At week 3, anamorelin administration resulted in body weight gain and increased the levels of growth hormone and HbA1c, as well as insulin-like growth factor-1 standard deviation scores (IGF-1 SD scores). At the same time, negative correlations were observed between ĢIGF-1 SD score and Ģthyroidstimulating hormone (TSH) and between ĢIGF-1 SD score and Ģfree testosterone. ĢBody weight and ĢIGF-1 SD score correlated positively at week 12. These results suggest that TSH and free testosterone levels can be affected 3 weeks after anamorelin administration; however, those variables tend to return to a state of equilibrium, and anabolic effects of anamorelin appear in long-term (? 12 weeks) users.
en-copyright=
kn-copyright=

en-aut-name=KuraokaSakiko
en-aut-sei=Kuraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatomiTakuya
en-aut-sei=Satomi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamazakiTatsuhiro
en-aut-sei=Yamazaki
en-aut-mei=Tatsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HamadaKenta
en-aut-sei=Hamada
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KonoYoshiyasu
en-aut-sei=Kono
en-aut-mei=Yoshiyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KanzakiHiromitsu
en-aut-sei=Kanzaki
en-aut-mei=Hiromitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=anamorelin
kn-keyword=anamorelin
en-keyword=body weight
kn-keyword=body weight
en-keyword=cancer cachexia
kn-keyword=cancer cachexia
en-keyword=endocrine system
kn-keyword=endocrine system
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=‰ºŠ{Ž}�‚’¼�œ�Ø‚è�p‚É”º‚¤‰ºŠ{“ª‚̈ʒu•Ï‰»‚¨‚æ‚ѕψʂɊ֘A‚·‚é—vˆö‚ÌŒŸ“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NAGATAYuki
en-aut-sei=NAGATA
en-aut-mei=Yuki
kn-aut-name=‰i“c—TŽ÷ 
kn-aut-sei=‰i“c
kn-aut-mei=—TŽ÷ 
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ž•ŽüŠ´�õ�E‰Š�Ç‚ª”D�P‚âŽq‹{‘g�D‚É‹y‚Ú‚·‰e‹¿‚̖ƉuŠw“IŒŸ“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NAGATAChiaki
en-aut-sei=NAGATA
en-aut-mei=Chiaki
kn-aut-name=‰i“c�ç�» 
kn-aut-sei=‰i“c
kn-aut-mei=�� 
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È
END

start-ver=1.4
cd-journal=joma
no-vol=18
cd-vols=
no-issue=2
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230224
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Diarrhea and related personal characteristics among Japanese university students studying abroad in intermediate- and low-risk countries
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Despite an increasing number of students studying abroad worldwide, evidence about health risks while they are abroad is limited. Diarrhea is considered the most common travelers' illness, which would also apply to students studying abroad. We examined diarrhea and related personal characteristics among Japanese students studying abroad. Japanese university students who participated in short-term study abroad programs between summer 2016 and spring 2018 were targeted (n = 825, 6-38 travel days). Based on a 2-week-risk of diarrhea (passing three or more loose or liquid stools per day) among travelers by country, the destination was separated into intermediate- and low-risk countries. After this stratification, the associations between personal characteristics and diarrhea during the first two weeks of their stay were evaluated using logistic regression models. Among participants in intermediate-risk countries, teenagers, males and those with overseas travel experience were associated with an elevated risk of diarrhea; the odds ratios (95% confidence intervals) were 2.42 (1.08-5.43) for teenagers (vs. twenties), 1.93 (1.08-3.45) for males (vs. females) and 2.37 (1.29-4.33) for those with overseas experience (vs. none). Even restricting an outcome to diarrhea during the first week did not change the results substantially. The same tendency was not observed for those in the low-risk countries. Teenage students, males and those with overseas travel experience should be cautious about diarrhea while studying abroad, specifically in intermediate-risk countries.
en-copyright=
kn-copyright=

en-aut-name=YamakawaMichiyo
en-aut-sei=Yamakawa
en-aut-mei=Michiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TsudaToshihide
en-aut-sei=Tsuda
en-aut-mei=Toshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WadaKeiko
en-aut-sei=Wada
en-aut-mei=Keiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NagataChisato
en-aut-sei=Nagata
en-aut-mei=Chisato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SuzukiEtsuji
en-aut-sei=Suzuki
en-aut-mei=Etsuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Human Ecology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Epidemiology and Preventive Medicine, Graduate School of Medicine, Gifu University
kn-affil=

affil-num=4
en-affil=Department of Epidemiology and Preventive Medicine, Graduate School of Medicine, Gifu University
kn-affil=

affil-num=5
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Renal cryoablation combined with prior transcatheter arterial embolization in non-dialysis patients with stage 4 or 5 chronic kidney disease: a retrospective study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose�@To retrospectively evaluate cryoablation combined with prior transcatheter arterial embolization (TAE) for renal cell carcinoma (RCC) in non-dialysis patients with stage 4 or 5 chronic kidney disease (CKD).<br>
Materials and methods�@Patients with stage 4 or 5 CKD undergoing TAE and cryoablation for RCC between May 2012 and October 2021 were included. TAE was selectively performed using iodized oil with absolute ethanol or gelatin sponge 1?14 days before cryoablation. Local efficacy, safety, and changes in renal function were evaluated.<br>
Results�@Nine patients (seven men and two women; median age, 64 years; range 52?88 years) with nine RCCs (mean diameter, 3.0?�}?1.0 cm; range 1.7?4.7 cm) were included. The mean pre-treatment estimated glomerular filtration rate (eGFR) was 24.2?�}?5.6 ml/min/1.73 m2 (range 10.4?29.2 ml/min/1.73 m2). The mean amount of contrast medium used in TAE was 58?�}?29 ml (range 40?128 ml). Except in one patient (grade 3 pyelonephritis), no grade???3 complications occurred. During the follow-up period (median, 18 months; range 7?54 months), no local tumor progression occurred. In two patients with pre-treatment eGFR of?<?20 ml/min/1.73 m2, hemodialysis was initiated at 3 and 19 months after cryoablation. At their last follow-up, the remaining seven patients showed a decrease of 6.2?�}?5.3 ml/min/1.73 m2 (range 0.7?17.2 ml/min/1.73 m2) in their eGFR.<br>
Conclusion�@Cryoablation combined with TAE for RCC in non-dialysis patients with stage 4 or 5 CKD was effective and safe, with an acceptable impact on renal function.
en-copyright=
kn-copyright=

en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KawabataTakahiro
en-aut-sei=Kawabata
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MunetomoKazuaki
en-aut-sei=Munetomo
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NagataShoma
en-aut-sei=Nagata
en-aut-mei=Shoma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=GobaraHideo
en-aut-sei=Gobara
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ArakiMotoo
en-aut-sei=Araki
en-aut-mei=Motoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Deptartment of Radiological Technology, Okayama University Graduate School of Health Science
kn-affil=

affil-num=3
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Division of Medical Informatics, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Urology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Renal cryoablation
kn-keyword=Renal cryoablation
en-keyword=Transcatheter arterial embolization
kn-keyword=Transcatheter arterial embolization
en-keyword=Chronic kidney disease
kn-keyword=Chronic kidney disease
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=3
article-no=
start-page=314
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230303
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Fungal Metabolite (+)-Terrein Abrogates Inflammatory Bone Resorption via the Suppression of TNF-ƒ¿ Production in a Ligature-Induced Periodontitis Mouse Model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Current periodontal treatment focuses on the mechanical removal of the source of infection, such as bacteria and their products, and there is no approach to control the host inflammatory response that leads to tissue destruction. In order to control periodontal inflammation, we have previously reported the optimization of (+)-terrein synthesis methods and the inhibitory effect of (+)-terrein on osteoclast differentiation in vitro. However, the pharmacological effect of (+)-terrein in vivo in the periodontitis model is still unknown. In this study, we investigated the effect of synthetic (+)-terrein on inflammatory bone resorption using a ligature-induced periodontitis mouse model. Synthetic (+)-terrein (30 mg/kg) was administered intraperitoneally twice a week to the mouse periodontitis model. The control group was treated with phosphate buffer. One to two weeks after the induction of periodontitis, the periodontal tissues were harvested for radiological evaluation (micro-CT), histological evaluation (HE staining and TRAP staining), and the evaluation of inflammatory cytokine production in the periodontal tissues and serum (quantitative reverse-transcription PCR, ELISA). The synthetic (+)-terrein-treated group suppressed alveolar bone resorption and the number of osteoclasts in the periodontal tissues compared to the control group (p < 0.05). In addition, synthetic (+)-terrein significantly suppressed both mRNA expression of TNF-ƒ¿ in the periodontal tissues and the serum concentration of TNF-ƒ¿ (both p < 0.05). In conclusion, we have demonstrated that synthetic (+)-terrein abrogates alveolar bone resorption via the suppression of TNF-ƒ¿ production and osteoclast differentiation in vivo. Therefore, we could expect potential clinical effects when using (+)-terrein on inflammatory bone resorption, including periodontitis.
en-copyright=
kn-copyright=

en-aut-name=SakoHidefumi
en-aut-sei=Sako
en-aut-mei=Hidefumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OmoriKazuhiro
en-aut-sei=Omori
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakayamaMasaaki
en-aut-sei=Nakayama
en-aut-mei=Masaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MandaiHiroki
en-aut-sei=Mandai
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IdeguchiHidetaka
en-aut-sei=Ideguchi
en-aut-mei=Hidetaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Yoshimura-NakagawaSaki
en-aut-sei=Yoshimura-Nakagawa
en-aut-mei=Saki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakaidaKyosuke
en-aut-sei=Sakaida
en-aut-mei=Kyosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=Nagata-KameiChiaki
en-aut-sei=Nagata-Kamei
en-aut-mei=Chiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KobayashiHiroya
en-aut-sei=Kobayashi
en-aut-mei=Hiroya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IshiiSatoki
en-aut-sei=Ishii
en-aut-mei=Satoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OnoMitsuaki
en-aut-sei=Ono
en-aut-mei=Mitsuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=IbaragiSoichiro
en-aut-sei=Ibaragi
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=YamamotoTadashi
en-aut-sei=Yamamoto
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SugaSeiji
en-aut-sei=Suga
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=TakashibaShogo
en-aut-sei=Takashiba
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Pharmacy, Faculty of Pharmacy, Gifu University of Medical Science
kn-affil=

affil-num=5
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Periodontics and Endodontics, Division of Dentistry, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Division of Applied Chemistry, Graduate School of Natural Sciences and Technology, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Oral and Maxillofacial Surgery and Biopathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=14
en-affil=Division of Applied Chemistry, Graduate School of Natural Sciences and Technology, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Pathophysiology-Periodontal Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=synthetic (+)-terrein
kn-keyword=synthetic (+)-terrein
en-keyword=periodontitis
kn-keyword=periodontitis
en-keyword= TNF-ƒ¿
kn-keyword= TNF-ƒ¿
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=2
article-no=
start-page=121
end-page=129
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Complications of Percutaneous Cryoablation for Renal Tumors and Methods for Avoiding Them
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Percutaneous cryoablation of renal tumors is widely used because of its high efficacy and safety. This high safety can be attributed, at least in part, to the visibility of the ablated area as an �gice ball�h. This therapy has fewer complications (incidence, 0-7.2%) and is less invasive than surgery. Minor bleeding is inevitable in most kidney-related procedures, and indeed the most common complication of this therapy is bleeding (hematoma and hematuria). However, patients require treatment such as transfusion or transarterial embolization in only 0-4% of bleeding cases. Various other complications such as ureteral or collecting system injury, bowel injury, nerve injury, skin injury, infection, pneumothorax, and tract seeding also occur, but they are usually minor and asymptomatic. However, operators should know and avoid the various complications associated with this therapy. This study aimed to summarize the complications of percutaneous cryoablation for renal tumors and provide some techniques for achieving safe procedures.
en-copyright=
kn-copyright=

en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TomitaKoji
en-aut-sei=Tomita
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=UmakoshiNoriyuki
en-aut-sei=Umakoshi
en-aut-mei=Noriyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KawabataTakahiro
en-aut-sei=Kawabata
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MunetomoKazuaki
en-aut-sei=Munetomo
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NagataShoma
en-aut-sei=Nagata
en-aut-mei=Shoma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ArakiMotoo
en-aut-sei=Araki
en-aut-mei=Motoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Radiology, Okayama University Hospital
kn-affil=
en-keyword=cryosurgery
kn-keyword=cryosurgery
en-keyword=kidney neoplasms
kn-keyword=kidney neoplasms
en-keyword=carcinoma
kn-keyword=carcinoma
en-keyword=renal cell
kn-keyword=renal cell
en-keyword=complication
kn-keyword=complication
END

start-ver=1.4
cd-journal=joma
no-vol=77
cd-vols=
no-issue=1
article-no=
start-page=105
end-page=109
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202302
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Initial Two Doses of COVID-19 Vaccine mRNA-1273 for an Individual Previously Vaccinated with Two Doses of an Inactivated Vaccine CoronaVac That Has Not Been Approved in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The inactivated coronavirus disease 2019 vaccine CoronaVac has not been approved in Japan. Little information is available on cases in Japan in which an approved mRNA vaccine was administered as the initial (first or second) dose after two doses of CoronaVac. Furthermore, the safety and efficacy of this combination are not established. We here evaluated the safety and efficacy in a patient who showed an antibody response to an approved vaccine, mRNA-1273, after a previous vaccination with CoronaVac. The adverse events consisted of only mild local and systemic common reactions and were transient. In addition, a strong and persistent antibody response was observed.
en-copyright=
kn-copyright=

en-aut-name=IwasakiYoshiaki
en-aut-sei=Iwasaki
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HiguchiChigusa
en-aut-sei=Higuchi
en-aut-mei=Chigusa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Health Service Center, Okayama University
kn-affil=

affil-num=2
en-affil=Health Service Center, Okayama University
kn-affil=
en-keyword=coronavirus disease 2019
kn-keyword=coronavirus disease 2019
en-keyword=severe acute respiratory syndrome coronavirus 2
kn-keyword=severe acute respiratory syndrome coronavirus 2
en-keyword=vaccine
kn-keyword=vaccine
en-keyword=adverse events
kn-keyword=adverse events
en-keyword=antibody response
kn-keyword=antibody response
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=6
article-no=
start-page=743
end-page=748
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Posterolateral Floating Technique for the Thoracic Ossification of the Posterior Longitudinal Ligament with Navigation: A Technical Note
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We describe a floating technique via a posterolateral approach with intraoperative O-arm navigation to facilitate decompression of the spinal cord in thoracic myelopathy due to severe ossification of the posterior longitudinal ligament (OPLL). A 62-year-old man with myelopathy due to thoracic OPLL had left-leg muscle weakness, urinary disturbance, and spastic gait. Bilateral leg pain and gait disturbance had persisted for 2 years. He was successfully treated by the posterolateral OPLL floating procedure and posterior pedicle fixation under O-arm navigation. At a 2-year follow-up, manual muscle testing results and sensory function of the left leg had recovered fully. His cervical Japanese Orthopedic Association score had improved from 5/12 to 11/12. The novel intraoperative O-arm navigation-guided posterolateral floating procedure for thoracic OPLL is effective for achieving precise decompression and strong fixation with a posterior approach only and can provide an excellent result for severe thoracic OPLL without the risk of adverse events from intraoperative radiation.
en-copyright=
kn-copyright=

en-aut-name=TanakaMasato
en-aut-sei=Tanaka
en-aut-mei=Masato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SutharHardik
en-aut-sei=Suthar
en-aut-mei=Hardik
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=DesaiDhvanit
en-aut-sei=Desai
en-aut-mei=Dhvanit
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamauchiTaro
en-aut-sei=Yamauchi
en-aut-mei=Taro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AratakiShinya
en-aut-sei=Arataki
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FujiwaraYoshihiro
en-aut-sei=Fujiwara
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=UotaniKoji
en-aut-sei=Uotani
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OdaYoshiaki
en-aut-sei=Oda
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MisawaHaruo
en-aut-sei=Misawa
en-aut-mei=Haruo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama Rosai Hospital
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=
en-keyword=ossification of the posterior longitudinal ligament
kn-keyword=ossification of the posterior longitudinal ligament
en-keyword=floating method
kn-keyword=floating method
en-keyword= navigation surgery
kn-keyword= navigation surgery
en-keyword=C-arm free
kn-keyword=C-arm free
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=6
article-no=
start-page=705
end-page=713
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Impact of Tofogliflozin on Physiological and Hormonal Function, Serum Electrolytes, and Cardiac Diastolic Function in Elderly Japanese Patients with Type 2 Diabetes Mellitus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The sodium glucose transporter 2 (SGLT2) inhibitor tofogliflozin is a glucose-lowering drug that causes the excretion of surplus glucose by inhibiting SGLT2. Because of tofogliflozin�fs osmotic diuresis mechanism, patients�f serum electrolytes, body fluid levels, and cardiac function must be monitored. We retrospectively analyzed the cases of 64 elderly Japanese patients with type 2 diabetes mellitus (T2DM) who received tofogliflozin for 3 months. Their HbA1c, serum electrolytes (sodium, potassium, chloride), hematocrit, brain natriuretic peptide (cardiac volume load marker) and renin and aldosterone (RAA; an index of regulatory hormones involved in body fluid retention) were continuously monitored during the investigation period. Renal function and cardiac function (by echocardiography) were assessed throughout the period. HbA1c significantly decreased (ƒÀ1=?0.341, p<0.0001, linear regression analysis [LRA]). Most of the hormonal, electrolyte, and physiological parameters were maintained throughout the study period. In these circumstances, E/e�f tended to decrease (ƒÀ1=?0.382, p=0.13, LRA). Compared to the baseline, E/e�f was significantly decreased at 1 and 3 months (p<0.01, p<0.05). In the higher E/e�f group (E/e�f?10, n=34), E/e�f decreased significantly (ƒÀ1=?0.63, p<0.05, LRA). ƒ¢E/e�f was correlated with body-weight change during treatment (r=0.64, p<0.01). The 3-month tofogliflozin treatment improved glycemic control and diastolic function represented by E/e�f in T2DM patients, without affecting serum electrolytes, renal function, or RAA. No negative impacts on the patients were observed. Three-month tofogliflozin treatment lowered glucose and improved cardiac diastolic function.
en-copyright=
kn-copyright=

en-aut-name=HigashikawaToshihiro
en-aut-sei=Higashikawa
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ItoTomohiko
en-aut-sei=Ito
en-aut-mei=Tomohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MizunoTakurou
en-aut-sei=Mizuno
en-aut-mei=Takurou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshigamiKeiichiro
en-aut-sei=Ishigami
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KurokiKengo
en-aut-sei=Kuroki
en-aut-mei=Kengo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MaekawaNaoto
en-aut-sei=Maekawa
en-aut-mei=Naoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=UsudaDaisuke
en-aut-sei=Usuda
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IzumidaToshihide
en-aut-sei=Izumida
en-aut-mei=Toshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamadaShinya
en-aut-sei=Yamada
en-aut-mei=Shinya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SangenRyusho
en-aut-sei=Sangen
en-aut-mei=Ryusho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HamadaKazu
en-aut-sei=Hamada
en-aut-mei=Kazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KiyosawaJun
en-aut-sei=Kiyosawa
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SaitoAtsushi
en-aut-sei=Saito
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=IguchiMasaharu
en-aut-sei=Iguchi
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KasamakiYuji
en-aut-sei=Kasamaki
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=NakahashiTakeshi
en-aut-sei=Nakahashi
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=FukudaAkihiro
en-aut-sei=Fukuda
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=SaitoHitoshi
en-aut-sei=Saito
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=KandaTsugiyasu
en-aut-sei=Kanda
en-aut-mei=Tsugiyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=OkuroMasashi
en-aut-sei=Okuro
en-aut-mei=Masashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

affil-num=1
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=2
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=3
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=4
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=5
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=6
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=7
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=8
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=9
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=10
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=11
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=12
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=13
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=14
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=15
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=16
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=17
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=18
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=19
en-affil=Kanazawa Medical University Himi Municipal Hospital
kn-affil=

affil-num=20
en-affil=Department of Geriatric Medicine, Kanazawa Medical University
kn-affil=
en-keyword=tofogliflozin
kn-keyword=tofogliflozin
en-keyword=SGLT2 inhibitor
kn-keyword=SGLT2 inhibitor
en-keyword=elderly patient
kn-keyword=elderly patient
en-keyword=HbA1c
kn-keyword=HbA1c
en-keyword=cardiac diastolic function
kn-keyword=cardiac diastolic function
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=3
article-no=
start-page=323
end-page=328
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=202206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Case of a Solitary Cortical Tuber with No Other Manifestations of Tuberous Sclerosis Complex Mimicking Focal Cortical Dysplasia Type II with Calcification
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cortical tubers are one of the typical intracranial manifestations of tuberous sclerosis complex (TSC). Multiple cortical tubers are easy to diagnose as TSC; however, a solitary cortical tuber without any other cutaneous or visceral organ manifestations can be confused with other conditions, particularly focal cortical dysplasia. We report a surgical case of refractory epilepsy caused by a solitary cortical tuber mimicking focal cortical dysplasia type II, and describe the radiological, electrophysiological, and histopathological findings of our case.
en-copyright=
kn-copyright=

en-aut-name=HosomotoKakeru
en-aut-sei=Hosomoto
en-aut-mei=Kakeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SasakiTatsuya
en-aut-sei=Sasaki
en-aut-mei=Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KawaiKoji
en-aut-sei=Kawai
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkazakiYosuke
en-aut-sei=Okazaki
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HyodoYuki
en-aut-sei=Hyodo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShibataTakashi
en-aut-sei=Shibata
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SasadaSusumu
en-aut-sei=Sasada
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YasuharaTakao
en-aut-sei=Yasuhara
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KobayashiKatsuhiro
en-aut-sei=Kobayashi
en-aut-mei=Katsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YanaiHiroyuki
en-aut-sei=Yanai
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Diagnostic Pathology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=cortical tuber
kn-keyword=cortical tuber
en-keyword=epilepsy
kn-keyword=epilepsy
en-keyword=focal cortical dysplasia
kn-keyword=focal cortical dysplasia
en-keyword=transmantle sign
kn-keyword=transmantle sign
en-keyword=tuberous sclerosis complex
kn-keyword=tuberous sclerosis complex
END

start-ver=1.4
cd-journal=joma
no-vol=53
cd-vols=
no-issue=3
article-no=
start-page=141
end-page=145
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=199906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Medical students�f perception of inpatients�f anxiety, self-esteem, purpose-in-life and health locus of control as compared with nursing practitioners�f
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Medical students (fourth-year: n = 67; fifth-year: n = 63) estimated inpatients' feelings of anxiety, self-esteem, purpose-in-life, and multidimensional health locus of control. Their ratings were compared both with the ratings given by the 121 inpatients themselves and with those given by nursing practitioners (nurses and nursing students). Findings showed that the medical students overestimated inpatients' anxiety, while they underestimated the inpatients' purpose-in-life and internal health locus of control. Hence they underestimated, as did the nursing practitioners, the inpatients' positive emotional states and their positive attitude toward their own lives. Fifth-year medical students, with clinical experience, rated the inpatients' score of chance health locus of control higher than did the fourth-year medical students, who had no clinical experience. These findings indicate that medical students, like nursing practitioners, are inclined to pay more attention to inpatients' weaknesses than to their strengths.
en-copyright=
kn-copyright=

en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhtaTakeo
en-aut-sei=Ohta
en-aut-mei=Takeo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AoyamaHideyasu
en-aut-sei=Aoyama
en-aut-mei=Hideyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Faculty of Economics, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Health Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Hygiene and Preventive Medicine, Okayama University Medical School
kn-affil=
en-keyword=inpatient's mental health
kn-keyword=inpatient's mental health
en-keyword=anxiety
kn-keyword=anxiety
en-keyword=self-esteem
kn-keyword=self-esteem
en-keyword=purpose-in-life
kn-keyword=purpose-in-life
en-keyword=health locus of control
kn-keyword=health locus of control
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=5
article-no=
start-page=625
end-page=629
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histologic Transformation from Follicular Lymphoma to Diffuse Large B-cell Lymphoma Detected during Colonoscopy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 77-year-old Japanese woman who had been treated for follicular lymphoma for 8 years developed abdominal pain and intra-abdominal lymphadenopathies. Colonoscopy revealed an elevated lesion in the rectum, which presented as two humps with erosions. A diagnosis of histologic transformation of follicular lymphoma to diffuse large B-cell lymphoma was made by endoscopic biopsy. This case underscores the importance of endoscopy examinations and biopsy of newly emerged gastrointestinal lesions for the prompt diagnosis of histologic transformation, since salvage chemotherapy must be initiated quickly in such cases.
en-copyright=
kn-copyright=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamasakiYasushi
en-aut-sei=Yamasaki
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaTakehiro
en-aut-sei=Tanaka
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AsadaNoboru
en-aut-sei=Asada
en-aut-mei=Noboru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsuokaKen-ichi
en-aut-sei=Matsuoka
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HiraokaSakiko
en-aut-sei=Hiraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawaharaYoshiro
en-aut-sei=Kawahara
en-aut-mei=Yoshiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Practical Gastrointestinal Endoscopy, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=colorectal lymphoma
kn-keyword=colorectal lymphoma
en-keyword=follicular lymphoma
kn-keyword=follicular lymphoma
en-keyword=diffuse large B-cell lymphoma
kn-keyword=diffuse large B-cell lymphoma
en-keyword=histologic transformation
kn-keyword=histologic transformation
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=4
article-no=
start-page=403
end-page=413
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Surgical Treatment of Epiretinal Membrane
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Epiretinal membrane (ERM) is a common retinal disease characterized by cellular proliferation and metaplasia that lead to the formation of a pathological fibrocellular membrane immediately superjacent to the inner retinal surface. The vast majority of ERMs are considered idiopathic. However, ERM formation can result from various primary intraocular diseases, including retinal breaks and detachment, retinal vascular diseases, and vitreoretinal inflammatory conditions. Although ERMs are generally asymptomatic or cause mild metamorphopsia and/or a modest decrease in visual acuity, some can cause severe macular distortion and macular edema, resulting in significantly impaired function. Surgical removal of ERM is the only treatment, and improvements in vitrectomy systems have enabled less invasive treatment. However, there are currently no standardized criteria for ERM surgery, and the indications for surgery are determined from the patient�fs subjective symptoms. Another problem with ERM surgery is that not all patients show satisfactory postoperative recovery of visual function. Thus, further research is needed to determine the criteria for ERM surgery and methods to improve the postoperative prognosis.
en-copyright=
kn-copyright=

en-aut-name=MatobaRyo
en-aut-sei=Matoba
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=epiretinal membrane
kn-keyword=epiretinal membrane
en-keyword=vitrectomy
kn-keyword=vitrectomy
en-keyword=optical coherence tomography
kn-keyword=optical coherence tomography
en-keyword=internal limiting membrane
kn-keyword=internal limiting membrane
en-keyword=lamellar macular hole
kn-keyword=lamellar macular hole
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=3
article-no=
start-page=345
end-page=349
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Predictors of Hypotension after Adrenalectomy for Pheochromocytoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The management of blood pressure is a significant concern for surgeons and anesthesiologists performing adrenalectomy for pheochromocytoma. We evaluated clinical factors in pheochromocytoma patients to identify the predictors of postoperative hypotension. The medical records of patients who underwent adrenalectomy for pheochromocytoma between 2001 and 2017 were retrospectively reviewed and clinical and biochemical data were evaluated. Of 29 patients, 13 patients needed catecholamine support in the perisurgical period while 16 patients did not. There were significant differences in median age, tumor size, and blood pressure drop (maxmin) between the 2 groups (68 vs 53 years old, p=0.045; 50 vs 32 mm diameter, p=0.022; 110 vs 71 mmHg, p=0.015 respectively). In univariate logistic analysis, age > 65.5 years, tumor size > 34.5 mm, urine metanephrine > 0.205 mg/day and urine normetanephrine > 0.665 mg/day were significant predictors of prolonged hypotension requiring postoperative catecholamine support. Tumor size and urine metanephrine and urine normetanephrine levels were correlated with postoperative hypotension. These predictors may help in the safe perioperative management of pheochromocytoma patients treated with adrenalectomy.
en-copyright=
kn-copyright=

en-aut-name=KoyamaKanae
en-aut-sei=Koyama
en-aut-mei=Kanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiuraNoriyoshi
en-aut-sei=Miura
en-aut-mei=Noriyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WatanabeRyuta
en-aut-sei=Watanabe
en-aut-mei=Ryuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SawadaYuichiro
en-aut-sei=Sawada
en-aut-mei=Yuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NodaTerutaka
en-aut-sei=Noda
en-aut-mei=Terutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NishimuraKenichi
en-aut-sei=Nishimura
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=AsaiSeiji
en-aut-sei=Asai
en-aut-mei=Seiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=FukumotoTetsuya
en-aut-sei=Fukumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YanagiharaYutaka
en-aut-sei=Yanagihara
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MiyauchiYuki
en-aut-sei=Miyauchi
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KikugawaTadahiko
en-aut-sei=Kikugawa
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SaikaTakashi
en-aut-sei=Saika
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=2
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=3
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=4
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=5
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=6
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=7
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=8
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=9
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=10
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=11
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=

affil-num=12
en-affil=Department of Urology, Graduate School of Medicine, Ehime University
kn-affil=
en-keyword=urinary metanephrine
kn-keyword=urinary metanephrine
en-keyword= urinary normetanephrine
kn-keyword= urinary normetanephrine
en-keyword=adrenalectomy
kn-keyword=adrenalectomy
en-keyword=pheochromocytoma
kn-keyword=pheochromocytoma
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=2
article-no=
start-page=115
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=202104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Awareness of Complications of Dental Treatment in Patients Treated with Drugs Affecting the Immune System : A Nationwide Questionnaire Survey of Dental Practitioners in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study was to investigate the awareness and experience, among dental practitioners, of adverse events resulting from dental treatment of patients undergoing therapy with drugs that affect the immune system [angiogenesis inhibitors, biological agents, immunosuppressants, and disease-modifying anti-rheumatic drugs (DMARDs)]. For this purpose, a nationwide questionnaire survey was conducted. Questionnaires were sent to 2,050 dentists, of which 206 (10.1%) were completed and returned. The results showed that most dentists were aware of complications associated with dental treatment of patients treated with drugs that affect the immune system, and about half had actually experienced such complications. Delayed wound healing, osteonecrosis of the jaw (ONJ), and postoperative infections were reported. Whereas approximately 50% of dentists did not discontinue the drugs during dental treatment, about 18% did. During temporary drug discontinuation, some patients experienced aggravation of the primary disease, such as worsening of rheumatism, growth of tumors, and rejection reactions of transplanted organs. As for medical cooperation, only less than half of the dentists were asked for oral hygiene management by a physician prior to starting the drug treatment. Prospective studies are needed because evidence for dental treatments in patients treated with these drugs remains limited.
en-copyright=
kn-copyright=

en-aut-name=HitomiNishizaki
en-aut-sei=Hitomi
en-aut-mei=Nishizaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YoshinariMorimoto
en-aut-sei=Yoshinari
en-aut-mei=Morimoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamadaShin-ichi
en-aut-sei=Yamada
en-aut-mei=Shin-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KuritaHiroshi
en-aut-sei=Kurita
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TanakaAkira
en-aut-sei=Tanaka
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamaguchiAkira
en-aut-sei=Yamaguchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyataMasaru
en-aut-sei=Miyata
en-aut-mei=Masaru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YoshikawaHiromasa 
en-aut-sei=Yoshikawa
en-aut-mei=Hiromasa 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YanamotoSouichi
en-aut-sei=Yanamoto
en-aut-mei=Souichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ImaiYutaka
en-aut-sei=Imai
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Critical Care Medicine and Dentistry, Graduate School of Dentistry, Kanagawa Dental University
kn-affil=

affil-num=2
en-affil=Department of Critical Care Medicine and Dentistry, Graduate School of Dentistry, Kanagawa Dental University
kn-affil=

affil-num=3
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=

affil-num=4
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=

affil-num=5
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=

affil-num=6
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=

affil-num=7
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=

affil-num=8
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=

affil-num=9
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=

affil-num=10
en-affil=The survey and research-planning committee, Japanese Society for Dentistry of Medically Compromised Patient
kn-affil=
en-keyword=angiogenesis inhibitor
kn-keyword=angiogenesis inhibitor
en-keyword=biological agent
kn-keyword=biological agent
en-keyword=disease-modifying antirheumatic drug (DMARD)
kn-keyword=disease-modifying antirheumatic drug (DMARD)
en-keyword=immunosuppressant
kn-keyword=immunosuppressant
en-keyword=medication-related osteonecrosis of the jaw (MRONJ)
kn-keyword=medication-related osteonecrosis of the jaw (MRONJ)
END

start-ver=1.4
cd-journal=joma
no-vol=22
cd-vols=
no-issue=3
article-no=
start-page=1024
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210120
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Genetic Elucidation for Response of Flowering Time to Ambient Temperatures in Asian Rice Cultivars
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Climate resilience of crops is critical for global food security. Understanding the genetic basis of plant responses to ambient environmental changes is key to developing resilient crops. To detect genetic factors that set flowering time according to seasonal temperature conditions, we evaluated differences of flowering time over years by using chromosome segment substitution lines (CSSLs) derived from japonica rice cultivars "Koshihikari" x "Khao Nam Jen", each with different robustness of flowering time to environmental fluctuations. The difference of flowering times in 9 years' field tests was large in "Khao Nam Jen" (36.7 days) but small in "Koshihikari" (9.9 days). Part of this difference was explained by two QTLs. A CSSL with a "Khao Nam Jen" segment on chromosome 11 showed 28.0 days' difference; this QTL would encode a novel flowering-time gene. Another CSSL with a segment from "Khao Nam Jen" in the region around Hd16 on chromosome 3 showed 23.4 days" difference. A near-isogenic line (NIL) for Hd16 showed 21.6 days' difference, suggesting Hd16 as a candidate for this QTL. RNA-seq analysis showed differential expression of several flowering-time genes between early and late flowering seasons. Low-temperature treatment at panicle initiation stage significantly delayed flowering in the CSSL and NIL compared with "Koshihikari". Our results unravel the molecular control of flowering time under ambient temperature fluctuations.
en-copyright=
kn-copyright=

en-aut-name=HoriKiyosumi
en-aut-sei=Hori
en-aut-mei=Kiyosumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SaishoDaisuke
en-aut-sei=Saisho
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NagataKazufumi
en-aut-sei=Nagata
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NonoueYasunori
en-aut-sei=Nonoue
en-aut-mei=Yasunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=Uehara-YamaguchiYukiko
en-aut-sei=Uehara-Yamaguchi
en-aut-mei=Yukiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KanataniAsaka
en-aut-sei=Kanatani
en-aut-mei=Asaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShuKoka
en-aut-sei=Shu
en-aut-mei=Koka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HirayamaTakashi
en-aut-sei=Hirayama
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YonemaruJun-Ichi
en-aut-sei=Yonemaru
en-aut-mei=Jun-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=FukuokaShuichi
en-aut-sei=Fukuoka
en-aut-mei=Shuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MochidaKeiichi
en-aut-sei=Mochida
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=

affil-num=4
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=

affil-num=5
en-affil=RIKEN Center for Sustainable Resource Science
kn-affil=

affil-num=6
en-affil=RIKEN Center for Sustainable Resource Science
kn-affil=

affil-num=7
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=

affil-num=8
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=9
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=

affil-num=10
en-affil=National Agriculture and Food Research Organization, Institute of Crop Science
kn-affil=

affil-num=11
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=rice
kn-keyword=rice
en-keyword=flowering time
kn-keyword=flowering time
en-keyword=ambient temperature fluctuation
kn-keyword=ambient temperature fluctuation
en-keyword=chromosome segment substitution line (CSSL)
kn-keyword=chromosome segment substitution line (CSSL)
en-keyword=quantitative trait locus (QTL)
kn-keyword=quantitative trait locus (QTL)
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=5
article-no=
start-page=455
end-page=459
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202010
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Study Protocol for Assessing the Efficacy of Compression Therapy Using Stockings and Sleeves to Prevent Docetaxel-Induced Peripheral Neuropathy in Breast Cancer Patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Taxanes are key drugs for patients with breast cancer. A major adverse effect associated with the administration of the taxane docetaxel is chemotherapy-induced peripheral neuropathy (CIPN). We are conducting a singlecenter, single-arm, open-label historical control trial to evaluate the ability of compression therapy using stockings or sleeves to prevent CIPN due to docetaxel treatment. The primary endpoint is the incidence of all-grade CIPN according to patients�f records until 3 weeks after the fourth docetaxel administration. This study�fs results will clarify whether compression therapy using stockings or sleeves can prevent CIPN in breast cancer patients.
en-copyright=
kn-copyright=

en-aut-name=YamanouchiKosho
en-aut-sei=Yamanouchi
en-aut-mei=Kosho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KubaSayaka
en-aut-sei=Kuba
en-aut-mei=Sayaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsumotoMegumi
en-aut-sei=Matsumoto
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YanoHiroshi
en-aut-sei=Yano
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MoritaMichi
en-aut-sei=Morita
en-aut-mei=Michi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SakimuraChika
en-aut-sei=Sakimura
en-aut-mei=Chika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OtsuboRyota
en-aut-sei=Otsubo
en-aut-mei=Ryota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KanetakaKengo
en-aut-sei=Kanetaka
en-aut-mei=Kengo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NagayasuTakeshi
en-aut-sei=Nagayasu
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=EguchiSusumu
en-aut-sei=Eguchi
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=2
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=3
en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=4
en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=5
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=6
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=7
en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=8
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=9
en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science
kn-affil=

affil-num=10
en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=docetaxel
kn-keyword=docetaxel
en-keyword=neuropathy
kn-keyword=neuropathy
en-keyword=compression
kn-keyword=compression
END

start-ver=1.4
cd-journal=joma
no-vol=240
cd-vols=
no-issue=3
article-no=
start-page=032001
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Numerical study of air-entraining and submerged vortices in a pump sump
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Numerical detection of harmful vortices in pump sumps, such as an air-entraining vortex (AEV) and a submerged vortex (SMV), is crucially important to develop the drain pump machinery. We performed numerical simulations of the benchmark experiments of the pump sump conducted by Matsui et al. (2006 and 2016) using the OpenFOAM and compared the simulation results with the experimental data considering the effects of turbulence model, grid density and detection method of the vortices. We studied the threshold of the gas-liquid volume fraction of the VOF method and the second invariant of velocity gradient tensor to identify AEV and SMV. The methods proposed in the present paper were found to be very effective for the detection of the vortices, and the simulation results by RANS with the SST k-omega model successfully reproduced the experimental data. LES with the Smagorinsky model, however, was sensitive to the grid system and difficult to reproduce the experimental data even for the finest grid system having 3.7 million cells in the present study.
en-copyright=
kn-copyright=

en-aut-name=YanaseShinichiro
en-aut-sei=Yanase
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamasakiRyo
en-aut-sei=Yamasaki
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KouchiToshinori
en-aut-sei=Kouchi
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HosodaShunsuke
en-aut-sei=Hosoda
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NagataYasunori
en-aut-sei=Nagata
en-aut-mei=Yasunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShunjiHiguchi
en-aut-sei=Shunji
en-aut-mei=Higuchi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawabeToshihiko
en-aut-sei=Kawabe
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakamiToshihiro
en-aut-sei=Takami
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=

affil-num=2
en-affil=Technical Division, Tsurumi Manufacturing Co.
kn-affil=

affil-num=3
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=

affil-num=6
en-affil=Technical Division, Tsurumi Manufacturing Co.
kn-affil=

affil-num=7
en-affil=Technical Division, Tsurumi Manufacturing Co.
kn-affil=

affil-num=8
en-affil=Department of Mechanical and Systems Engineering, Okayama University of Science
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=3
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190603
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Solid-state nuclear magnetic resonance study of setting mechanism of beta-tricalcium phosphate-inositol phosphate composite cements
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Solid-state nuclear magnetic resonance (NMR) spectroscopy is a technique, which can be used to provide insight into the chemical structure of non-crystalline and crystalline materials. Hence, the present study aimed to elucidate the setting mechanism of CPC, which was fabricated using beta -tricalcium phosphate (beta -TCP)-inositol phosphate (IP6) composite powder using NMR In addition, the effect of IP6 on the local chemical structure of the beta -TCP-IP6 composite powder and its hardened cement would also be investigated. The H-1 -> P-31 heteronuclear correlation NMR spectrum revealed that an amorphous hydrated layer, along with small amount of hydroxyapatite (HA) was formed on the surface of beta -TCP during the ball-milling process. Results demonstrated that the IP6 in the hydrated layer on the surface of beta -TCP inhibited the formation of HA. Moreover, the setting reaction of the cement was mainly triggered by the dissolution of the amorphous hydrated layer on beta -TCP surface, and subsequent precipitation, followed by the inter-entanglement between the HA crystals on the beta -TCP.
en-copyright=
kn-copyright=

en-aut-name=KonishiToshiisa
en-aut-sei=Konishi
en-aut-mei=Toshiisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamashitaKohei
en-aut-sei=Yamashita
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NagataKohei
en-aut-sei=Nagata
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=LimPoon Nian
en-aut-sei=Lim
en-aut-mei=Poon Nian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ThianEng San
en-aut-sei=Thian
en-aut-mei=Eng San
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AizawaMamoru
en-aut-sei=Aizawa
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University
kn-affil=

affil-num=4
en-affil=Department of Mechanical Engineering, National University of Singapore
kn-affil=

affil-num=5
en-affil=Department of Mechanical Engineering, National University of Singapore
kn-affil=

affil-num=6
en-affil=Department of Applied Chemistry, School of Science and Technology, Meiji University
kn-affil=
en-keyword=beta-tricalcium phosphate
kn-keyword=beta-tricalcium phosphate
en-keyword=calcium-phosphate cement
kn-keyword=calcium-phosphate cement
en-keyword=inositol phosphate
kn-keyword=inositol phosphate
en-keyword=solid-state NMR
kn-keyword=solid-state NMR
en-keyword=setting mechanism
kn-keyword=setting mechanism
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=2
article-no=
start-page=103
end-page=108
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Switching from Treatment with Amlodipine and Atorvastatin Using Two Pills to an Equal Dose of Single-Pill Therapy in Japanese Outpatients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= This study examined whether switching from amlodipine and atorvastatin treatment using two pills to an equal dose of single-pill therapy is useful in Japanese outpatients. We retrospectively reviewed data obtained from 94 outpatients for whom treatment with two pills, namely amlodipine and atorvastatin, was switched to an equal dose of single-pill therapy in 11 hospitals. The criterion for enrollment in this study was that patients had switched their medication without changing other anti-hypertensive or anti-cholesterol drugs. Neither systolic nor diastolic blood pressure changed significantly after switching to an equal dose of single-pill therapy, whereas low-density lipoprotein (LDL) cholesterol levels significantly decreased after the medication was switched from 94�}24 mg/dl to 89�}17 mg/dl (p=0.015). A switch from medication with two separate pills of amlodipine and atorvastatin to an equal dose of single-pill therapy resulted in an overall decrease in LDL cholesterol. The results indicated that the switch to single-pill therapy might be a useful treatment.
en-copyright=
kn-copyright=

en-aut-name=KawadaYasumasa
en-aut-sei=Kawada
en-aut-mei=Yasumasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KuboToru
en-aut-sei=Kubo
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BabaYuichi
en-aut-sei=Baba
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HirotaTakayoshi
en-aut-sei=Hirota
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TaniokaKatsutoshi
en-aut-sei=Tanioka
en-aut-mei=Katsutoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamasakiNaohito
en-aut-sei=Yamasaki
en-aut-mei=Naohito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KitaokaHiroaki
en-aut-sei=Kitaoka
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=2
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=3
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=4
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=5
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=6
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=

affil-num=7
en-affil=Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
kn-affil=
en-keyword=hypertension
kn-keyword=hypertension
en-keyword=dyslipidemia
kn-keyword=dyslipidemia
en-keyword=single-pill therapy
kn-keyword=single-pill therapy
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4
article-no=
start-page=367
end-page=372
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.
en-copyright=
kn-copyright=

en-aut-name=Mifune-MoriokaTomoyo
en-aut-sei=Mifune-Morioka
en-aut-mei=Tomoyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=A.  UchidaHaruhito
en-aut-sei=A.  Uchida
en-aut-mei=Haruhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FukushimaKazuhiko
en-aut-sei=Fukushima
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WatanabeMayu
en-aut-sei=Watanabe
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OuchiChihiro
en-aut-sei=Ouchi
en-aut-mei=Chihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiseKoki
en-aut-sei=Mise
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawakitaChieko
en-aut-sei=Kawakita
en-aut-mei=Chieko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KanoYuzuki
en-aut-sei=Kano
en-aut-mei=Yuzuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OnishiAkifumi
en-aut-sei=Onishi
en-aut-mei=Akifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TomaKishio
en-aut-sei=Toma
en-aut-mei=Kishio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=EguchiJun
en-aut-sei=Eguchi
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=WadaNozomu
en-aut-sei=Wada
en-aut-mei=Nozomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IkedaFusao
en-aut-sei=Ikeda
en-aut-mei=Fusao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SasakiErika
en-aut-sei=Sasaki
en-aut-mei=Erika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=SuganamiYu
en-aut-sei=Suganami
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=KishidaMasayuki
en-aut-sei=Kishida
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=SugiyamaHitoshi
en-aut-sei=Sugiyama
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Human Resource Development of Dialysis Therapy for Kidney Disease,  Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of General Internal Medicine and Endocrinology, Okayama City Hospital
kn-affil=

affil-num=15
en-affil=Department of General Internal Medicine and Endocrinology, Okayama City Hospital
kn-affil=

affil-num=16
en-affil=Department of General Internal Medicine and Endocrinology, Okayama City Hospital
kn-affil=

affil-num=17
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=18
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=19
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=autoimmune polyglandular syndrome type 3
kn-keyword=autoimmune polyglandular syndrome type 3
en-keyword=systemic lupus erythematosus
kn-keyword=systemic lupus erythematosus
en-keyword=autoimmune hepatitis
kn-keyword=autoimmune hepatitis
en-keyword=slowly progressive insulin-dependent diabetes mellitus
kn-keyword=slowly progressive insulin-dependent diabetes mellitus
en-keyword=chronic thyroiditis
kn-keyword=chronic thyroiditis
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4
article-no=
start-page=361
end-page=365
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Case of Primary Colonic Signet Ring Cell Carcinoma in a Young Man which Preoperatively Mimicked Phlebosclerotic Colitis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A 35-year-old man was referred to our hospital for chronic abdominal pain and diarrhea. Computed tomography showed wall thickening, poor contrast enhancement and calcification of the ascending colon, which were consistent with phlebosclerotic colitis. Malignant character was not detected from a biopsy specimen. Operatively, we observed a scirrhous mass of the ascending colon invading surrounding tissue, which was diagnosed as signet ring cell carcinoma based on analysis of an intraoperative frozen section. Right hemicolectomy with regional lymph node dissection was performed. This case was extremely similar to phlebosclerotic colitis in clinical findings; surgical resection was required for correct diagnosis.
en-copyright=
kn-copyright=

en-aut-name=WatanabeAyako
en-aut-sei=Watanabe
en-aut-mei=Ayako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KadowakiYoshihiko
en-aut-sei=Kadowaki
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HattoriKenji
en-aut-sei=Hattori
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OhmoriMika
en-aut-sei=Ohmori
en-aut-mei=Mika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsukayamaHiroyuki
en-aut-sei=Tsukayama
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KubotaNobuhito
en-aut-sei=Kubota
en-aut-mei=Nobuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkumotoTatsuo
en-aut-sei=Okumoto
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshidoNobuhiro
en-aut-sei=Ishido
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OkinoTakeshi
en-aut-sei=Okino
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=

affil-num=2
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=

affil-num=3
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=

affil-num=4
en-affil=Department of Radiology, Japanese Red Cross Kobe Hospital
kn-affil=

affil-num=5
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=

affil-num=6
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=

affil-num=7
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=

affil-num=8
en-affil=Department of Surgery, Japanese Red Cross Kobe Hospital
kn-affil=

affil-num=9
en-affil=Department of Pathology, Japanese Red Cross Kobe Hospital
kn-affil=
en-keyword=phlebosclerotic colitis
kn-keyword=phlebosclerotic colitis
en-keyword=colorectal cancer
kn-keyword=colorectal cancer
en-keyword=signet ring cell carcinoma
kn-keyword=signet ring cell carcinoma
en-keyword=young colorectal cancer
kn-keyword=young colorectal cancer
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=4
article-no=
start-page=285
end-page=297
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Dynamic Reorganization of Microtubule and Glioma Invasion
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Gliomas are characterized as highly diffuse infiltrating tumors, and currently available treatments such as surgery, radiation and chemotherapy are unfeasible or show limited efficacy against these tumors. Recent genetic and epigenetic analyses of glioma have revealed increasing evidence of the role of driver genetic alterations in glioma development and led to the identification of prognostic factors. Despite these findings, the survival rates of glioma patients remain low, and alternative treatments and novel targets are needed. Recent studies identified neural stem cells as the possible origin of gliomas, and some evidence has revealed shared functions and mechanisms between glioma cells and neurons, also supporting their similarity. The cytoskeleton plays important roles in the migration of normal cells as well as cancer cells. Recent reports have described a role for microtubules, a component of the cytoskeleton, in glioma invasion. Notably, several factors that regulate microtubule functions, such as microtubule-associated proteins, plus-end tracking proteins, or motor proteins, are upregulated in glioma tissues compared with normal tissue, and upregulation of these factors is associated with high invasiveness of glioma cells. In this review, we describe the mechanism of microtubules in glioma invasion and discuss the possibility of microtubule-targeted therapy to inhibit glioma invasion.
en-copyright=
kn-copyright=

en-aut-name=OtaniYoshihiro
en-aut-sei=Otani
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IchikawaTomotsugu
en-aut-sei=Ichikawa
en-aut-mei=Tomotsugu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KurozumiKazuhiko
en-aut-sei=Kurozumi
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Neurosurgery, The University of Texas Health Science Center at Houston
kn-affil=

affil-num=2
en-affil=Department of Neurosurgery, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=3
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=glioma
kn-keyword=glioma
en-keyword=cytoskeletons
kn-keyword=cytoskeletons
en-keyword=invasion
kn-keyword=invasion
en-keyword=microtubules
kn-keyword=microtubules
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=3
article-no=
start-page=263
end-page=267
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sudden, Sharp Turn in an AIDS Patient�fs Course Following the Onset of Fulminant Type 1 Diabetes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A previously healthy 40-year-old Japanese male was urgently admitted with a 2-month history of dysphagia, 30-kg weight loss, and fever. Human immunodeficiency virus (HIV) antibodies and cytomegalovirus antigenemia were positive. Pneumocystis pneumonia and cytomegalovirus pneumonia were suspected. The patient was diagnosed with acquired immune deficiency syndrome (AIDS). Cytomegalovirus antigenemia became negative 20 days after the positive result. On hospital day 41, he experienced cardiopulmonary arrest. The clinical diagnosis was fulminant type 1 diabetes mellitus. He later developed hypoglycemia and was diagnosed with adrenal insufficiency accompanied by septic shock. He died of multiple organ failure 29 h post-admission to our ICU.
en-copyright=
kn-copyright=

en-aut-name=ShimoyamaYuichiro
en-aut-sei=Shimoyama
en-aut-mei=Yuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UmegakiOsamu
en-aut-sei=Umegaki
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OoiYukimasa
en-aut-sei=Ooi
en-aut-mei=Yukimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShigemotoSho
en-aut-sei=Shigemoto
en-aut-mei=Sho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AguiTomoyuki
en-aut-sei=Agui
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KadonoNoriko
en-aut-sei=Kadono
en-aut-mei=Noriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MinamiToshiaki
en-aut-sei=Minami
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Intensive Care Unit, Osaka Medical College Hospital
kn-affil=

affil-num=2
en-affil=Department of Intensive Care Unit, Osaka Medical College Hospital
kn-affil=

affil-num=3
en-affil=Department of Internal Medicine, Osaka Medical College Hospital
kn-affil=

affil-num=4
en-affil=Department of Internal Medicine, Osaka Medical College Hospital
kn-affil=

affil-num=5
en-affil=Department of Surgery, Osaka Medical College Hospital
kn-affil=

affil-num=6
en-affil=Department of Intensive Care Unit, Osaka Medical College Hospital
kn-affil=

affil-num=7
en-affil=Department ofAnesthesiology, Osaka Medical College Hospital
kn-affil=
en-keyword=fulminant type 1 diabetes mellitus
kn-keyword=fulminant type 1 diabetes mellitus
en-keyword=human immunodeficiency virus
kn-keyword=human immunodeficiency virus
en-keyword=cytomegalovirus
kn-keyword=cytomegalovirus
en-keyword=hypoglycemia
kn-keyword=hypoglycemia
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histidine-rich Glycoprotein Could Be an Early Predictor of Vasospasm after Aneurysmal Subarachnoid Hemorrhage
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Cerebral vasospasm (CVS) is a major contributor to the high morbidity and mortality of aneurysmal subarachnoid hemorrhage (aSAH) patients. We measured histidine-rich glycoprotein (HRG), a new biomarker of aSAH, in cerebrospinal fluid (CSF) to investigate whether HRG might be an early predictor of CVS. A total of seven controls and 14 aSAH patients (8 males, 6 females aged 53.4�}15.4 years) were enrolled, and serial CSF and serum samples were taken. We allocated these samples to three phases (T1-T3) and measured HRG, interleukin (IL)-6, fibrinopeptide A (FpA), and 8-hydroxy-2�f-deoxyguanosine (8OHdG) in the CSF, and the HRG in serum. We also examined the release of HRG in rat blood incubated in artificial CSF. In contrast to the other biomarkers examined, the change in the CSF HRG concentration was significantly different between the nonspasm and spasm groups (p<0.01). The rat blood/CSF model revealed a time course similar to that of the human CSF samples in the non-spasm group. HRG thus appears to have the potential to become an early predictor of CVS. In addition, the interaction of HRG with IL-6, FpA, and 8OHdG may form the pathology of CVS.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoAtsushi
en-aut-sei=Matsumoto
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraTakehiro
en-aut-sei=Nakamura
en-aut-mei=Takehiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShinomiyaAya
en-aut-sei=Shinomiya
en-aut-mei=Aya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawakitaKenya
en-aut-sei=Kawakita
en-aut-mei=Kenya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawanishiMasahiko
en-aut-sei=Kawanishi
en-aut-mei=Masahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyakeKeisuke
en-aut-sei=Miyake
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KurodaYasuhiro
en-aut-sei=Kuroda
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KeepRichard F.
en-aut-sei=Keep
en-aut-mei=Richard F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TamiyaTakashi
en-aut-sei=Tamiya
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=2
en-affil=Department of Medical Technology, Kagawa Prefectural University of Health Sciences
kn-affil=

affil-num=3
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=4
en-affil=Emergency Medical Center, Kagawa University Hospital
kn-affil=

affil-num=5
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=6
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=

affil-num=7
en-affil=Emergency Medical Center, Kagawa University Hospital
kn-affil=

affil-num=8
en-affil=Department of Neurosurgery, University of Michigan
kn-affil=

affil-num=9
en-affil=Department of Neurological Surgery, Kagawa University Faculty of Medicine
kn-affil=
en-keyword=biomarker
kn-keyword=biomarker
en-keyword=histidine-rich glycoprotein
kn-keyword=histidine-rich glycoprotein
en-keyword=predictor
kn-keyword=predictor
en-keyword=subarachnoid hemorrhage
kn-keyword=subarachnoid hemorrhage
en-keyword=vasospasm
kn-keyword=vasospasm
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=1
article-no=
start-page=21
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Clitoral Blood Flow Changes after Surgery with Tension-Free Vaginal Mesh for Pelvic Organ Prolapse
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We measured basal clitoral blood flow by Doppler sonography to determine whether tension-free vaginal mesh(TVM) affects the clitoral blood flow and sexual function in women with pelvic organ prolapse (POP). We performed a prospective study of 22 patients who underwent TVM for POP. Clitoral blood flow was measured by Doppler ultrasound. The resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) of the clitoral arteries were measured preoperatively and at 1, 3, and 6 months postoperatively. Female sexual function was also investigated with the Female Sexual Function Index (FSFI). The mean PI and RI were increased at 1 month and significantly decreased at 6 months postoperatively (p<0.05). In contrast, the mean PSV and EDV decreased at 1 month postoperatively and increased at 6 months postoperatively. These four parameters recovered to baseline levels at 6 months following surgery. Total FSFI scores improved significantly from 10.2�}7.9 at baseline to 18.2�}8.9 at 6 months postoperatively. Color Doppler ultrasonography is potentially useful in measuring clitoral blood flow in patients treated with TVM for POP. Prospective long-term studies are needed to evaluate the utility of this modality as a diagnostic and prognostic tool for female sexual dysfunction.
en-copyright=
kn-copyright=

en-aut-name=OiwaYuko
en-aut-sei=Oiwa
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WatanabeToyohiko
en-aut-sei=Watanabe
en-aut-mei=Toyohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SadahiraTakuya
en-aut-sei=Sadahira
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiiAyano
en-aut-sei=Ishii
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakoTomoko
en-aut-sei=Sako
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=InoueMiyabi
en-aut-sei=Inoue
en-aut-mei=Miyabi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=WadaKoichiro
en-aut-sei=Wada
en-aut-mei=Koichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KobayashiYasuyuki
en-aut-sei=Kobayashi
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ArakiMotoo
en-aut-sei=Araki
en-aut-mei=Motoo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NasuYasutomo
en-aut-sei=Nasu
en-aut-mei=Yasutomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Integrated Support Center for Patients and Self-learning, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Miyabi Urogyne Clinic
kn-affil=

affil-num=7
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=clitoris
kn-keyword=clitoris
en-keyword=pelvic organ prolapse
kn-keyword=pelvic organ prolapse
en-keyword=Doppler ultrasound
kn-keyword=Doppler ultrasound
END

start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=845
article-no=
start-page=16-00441
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=2017
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Large-scale vortical structure detection using microphone array in a semiconductor single wafer spin cleaner
kn-title=ƒ}ƒCƒNƒ�ƒtƒHƒ“ƒAƒŒƒC‚ð—p‚¢‚½–‡—tŽ®”¼“±‘Ì�ô�ò‘•’u“à‚ÉŒ`�¬‚³‚ê‚é‘å‹K–͉Q�\‘¢‚ÌŒŸ�o
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Fluctuating pressure (p�f ) of a large-scale vortical structure generated in a semiconductor single wafer spin cleaner was detected by using microphone array. Twelve microphones were installed on the exhaust cover under the rotating disk of the cleaner with their interval of 7.5�‹ or 15�‹. Power spectrum densities (PSD) of p�f were compared with those of fluctuating velocity measured by PIV for various rotation angular velocities to identify fluctuations due to convection of the large-scale vortical structure. Good agreement of PSDs indicates that the large-scale structure could be detected by using microphone. Cross-correlation of p�f measured at different positions revealed that the large-scale structure convected to the downstream in the rotational direction of the disk. The convection speed was about 12 % of the angular velocity of the rotating disk. Number of the vortex in the large-scale structure was also evaluated from the time-series p�f data. Time-space contour map was made for p�f based on the data measured at the different angular position, and showed periodical swept strip patterns. Presences of the strip patterns indicate the pressure disturbances were stably convected to the downstream. From this time-space map, two-dimensional Fourier transform efficiently extracted the number of vortices in the large-scale structure.
en-copyright=
kn-copyright=

en-aut-name=KOUCHIToshinori
en-aut-sei=KOUCHI
en-aut-mei=Toshinori
kn-aut-name=‰Í“à�rŒ›
kn-aut-sei=‰Í“à
kn-aut-mei=�rŒ›
aut-affil-num=1
ORCID=

en-aut-name=MIYOSHIYuki
en-aut-sei=MIYOSHI
en-aut-mei=Yuki
kn-aut-name=ŽO�D—E‹P
kn-aut-sei=ŽO�D
kn-aut-mei=—E‹P
aut-affil-num=2
ORCID=

en-aut-name=NAKANOYusuke
en-aut-sei=NAKANO
en-aut-mei=Yusuke
kn-aut-name=’†–ì—T‰î
kn-aut-sei=’†–ì
kn-aut-mei=—T‰î
aut-affil-num=3
ORCID=

en-aut-name=NAGATAYasunori
en-aut-sei=NAGATA
en-aut-mei=Yasunori
kn-aut-name=‰i“c–õ“T
kn-aut-sei=‰i“c
kn-aut-mei=–õ“T
aut-affil-num=4
ORCID=

en-aut-name=YANASEShinichiro
en-aut-sei=YANASE
en-aut-mei=Shinichiro
kn-aut-name=–ö�£áÁˆê˜Y
kn-aut-sei=–ö�£
kn-aut-mei=áÁˆê˜Y
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=2
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=3
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=4
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=5
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È
en-keyword=Rotating disk
kn-keyword=Rotating disk
en-keyword=Flow stability
kn-keyword=Flow stability
en-keyword=Coherent structure
kn-keyword=Coherent structure
en-keyword=Differential pressure measurement
kn-keyword=Differential pressure measurement
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=829
article-no=
start-page=15-00273
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=2015
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Periodical structure of vortices in a semiconductor single wafer spin cleaner
kn-title=–‡—tŽ®”¼“±‘Ì�ô�ò‘•’u“à‚ÉŒ`�¬‚³‚ê‚é‰Q‚ÌŽüŠú�\‘¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We experimentally and numerically investigated large-scale structures formed by vortices in a single wafer spin cleaner. The Q-criterion identified the vortices developed in the cleaner as the flow regions with positive second invariant of the velocity gradient tensor obtained by both the PIV and LES. The time-series two-components PIV data shows that small-vortices were clustered near and under the edge of the rotating disk and were periodically emanated from there to the housing wall of the cleaner. The emanation frequency was increased with increasing in the angular velocity of the rotating disk. Three-dimensional LES reveal that six longitudinal vortices were spirally developed from under the edge of the rotating disk to the housing wall. This structure stably rotated slower than the disk speed. Fourier analysis of the LES data agreed with that of the PIV data. This supports that the passages of the stable spiral vortices on the PIV measurement region resulted in the periodical emanation of the clustered small-vortices observed in the PIV. Such a very large-scale spiral structure will induce reattachment of contaminants on the wafer surface, and should be destructed for development of much higher efficient cleaner.
en-copyright=
kn-copyright=

en-aut-name=KOUCHIToshinori
en-aut-sei=KOUCHI
en-aut-mei=Toshinori
kn-aut-name=‰Í“à�rŒ›
kn-aut-sei=‰Í“à
kn-aut-mei=�rŒ›
aut-affil-num=1
ORCID=

en-aut-name=FUKUDANaoya
en-aut-sei=FUKUDA
en-aut-mei=Naoya
kn-aut-name=•Ÿ“c�C–ç
kn-aut-sei=•Ÿ“c
kn-aut-mei=�C–ç
aut-affil-num=2
ORCID=

en-aut-name=NAKANOYusuke
en-aut-sei=NAKANO
en-aut-mei=Yusuke
kn-aut-name=’†–ì—T‰î
kn-aut-sei=’†–ì
kn-aut-mei=—T‰î
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ORCID=

en-aut-name=SHIMIZUYoshiya
en-aut-sei=SHIMIZU
en-aut-mei=Yoshiya
kn-aut-name=�´�…‹`–ç
kn-aut-sei=�´�…
kn-aut-mei=‹`–ç
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en-aut-name=NAGATAYasunori
en-aut-sei=NAGATA
en-aut-mei=Yasunori
kn-aut-name=‰i“c–õ“T
kn-aut-sei=‰i“c
kn-aut-mei=–õ“T
aut-affil-num=5
ORCID=

en-aut-name=YANASEShinichiro
en-aut-sei=YANASE
en-aut-mei=Shinichiro
kn-aut-name=–ö�£áÁˆê˜Y
kn-aut-sei=–ö�£
kn-aut-mei=áÁˆê˜Y
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=2
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=3
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=4
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=5
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=6
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È
en-keyword=Rotating disk
kn-keyword=Rotating disk
en-keyword=Flow stability
kn-keyword=Flow stability
en-keyword=Large-scale structure
kn-keyword=Large-scale structure
en-keyword=PIV
kn-keyword=PIV
en-keyword=LES
kn-keyword=LES
END

start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=853
article-no=
start-page=17-00181
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=2017
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=OpenFOAM analysis of air-entraining and submerged vortices in pump sump
kn-title=OpenFOAM‚ð—p‚¢‚½ƒ|ƒ“ƒv�…‘…“à‚É”­�¶‚·‚é‹ó‹C‹z�ž‰Q‚Æ�…’†‰Q‚̉ð�Í
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YAMASAKIRyo
en-aut-sei=YAMASAKI
en-aut-mei=Ryo
kn-aut-name=ŽR�è—È
kn-aut-sei=ŽR�è
kn-aut-mei=—È
aut-affil-num=1
ORCID=

en-aut-name=KOUCHIToshinori
en-aut-sei=KOUCHI
en-aut-mei=Toshinori
kn-aut-name=‰Í“à�rŒ›
kn-aut-sei=‰Í“à
kn-aut-mei=�rŒ›
aut-affil-num=2
ORCID=

en-aut-name=NAGATAYasunori
en-aut-sei=NAGATA
en-aut-mei=Yasunori
kn-aut-name=‰i“c–õ“T
kn-aut-sei=‰i“c
kn-aut-mei=–õ“T
aut-affil-num=3
ORCID=

en-aut-name=YANASEShinichiro
en-aut-sei=YANASE
en-aut-mei=Shinichiro
kn-aut-name=–ö�£áÁˆê˜Y
kn-aut-sei=–ö�£
kn-aut-mei=áÁˆê˜Y
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=2
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=3
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È

affil-num=4
en-affil=Mechanical and System Engineering of Okayama University
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ Ž©‘R‰ÈŠwŒ¤‹†‰È
en-keyword=CFD
kn-keyword=CFD
en-keyword=VOF
kn-keyword=VOF
en-keyword=Turbulance model
kn-keyword=Turbulance model
en-keyword=Grid convergence
kn-keyword=Grid convergence
en-keyword=Vortex detection scheme
kn-keyword=Vortex detection scheme
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=5
article-no=
start-page=427
end-page=432
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201710
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Direct Damage to a Vertebral Artery Better Predicts a Vertebral Artery Injury than Elongation in Cervical Spine Dislocation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Cervical spine dislocation and fracture of a transverse process are isolated risk factors for vertebral artery injuries (VAIs), which can cause a life-threatening ischemic stroke. Since in vivo experiments are not possible, it has not been unclear whether damage to or extension of vertebral arteries is more predictive of a VAI. To identify the imaging characteristics associated with VAI, we analyzed 36 vertebral arteries from 22 cervical spine dislocation patients who underwent computed tomography angiography (Aug. 2008-Dec. 2014). We evaluated (1) the posttraumatic elongation of the vertebral artery and (2) the presence of fracture involving the transverse foramen. VAI was found in 20 (56%) of the 36 vertebral arteries. The rate of residual shift (vertebral artery elongation) was not markedly different between the VAI and no-VAI groups. However, the rate of >1 mm displacement into the foramen and that of fracture with gross displacement (?2 mm) differed significantly between the groups. We found that greater displacement of fractured transverse processes with cervical spine dislocation was a risk factor for VAI. These results suggest that direct damage to the vertebral arteries by transverse process fragments is more likely to predict a VAI compared to elongation, even in cervical spine dislocation.
en-copyright=
kn-copyright=

en-aut-name=NagataKosei
en-aut-sei=Nagata
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ChikudaHirotaka
en-aut-sei=Chikuda
en-aut-mei=Hirotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=InokuchiKoichi
en-aut-sei=Inokuchi
en-aut-mei=Koichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiiKeisuke
en-aut-sei=Ishii
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KobayashiAtsuki
en-aut-sei=Kobayashi
en-aut-mei=Atsuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KanaiHiroyuki
en-aut-sei=Kanai
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyoshiKota
en-aut-sei=Miyoshi
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery and Spinal Surgery, The University of Tokyo Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery and Spinal Surgery, The University of Tokyo Hospital
kn-affil=

affil-num=3
en-affil=Advanced Critical Care Center, Saitama Medical Center, Saitama Medical University
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Tokyo Metropolitan Bokutoh Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Tokyo Metropolitan Bokutoh Hospital
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Tokyo Metropolitan Bokutoh Hospital
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=
en-keyword=vertebral artery injury
kn-keyword=vertebral artery injury
en-keyword=cervical spine dislocation
kn-keyword=cervical spine dislocation
en-keyword=CT angiography
kn-keyword=CT angiography
en-keyword=transverse process
kn-keyword=transverse process
en-keyword=vertebral artery elongation
kn-keyword=vertebral artery elongation
END

start-ver=1.4
cd-journal=joma
no-vol=129
cd-vols=
no-issue=1
article-no=
start-page=17
end-page=22
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170403
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Sexual function before and after a tension-free vaginal mesh procedure for pelvic organ prolapse
kn-title=�œ”Õ‘ŸŠí’E‚ɑ΂·‚éTVM Žè�p‘OŒã‚Ì�«‹@”\‚ÉŠÖ‚·‚錟“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We prospectively assessed sexual function before and after a tension-free vaginal mesh ( TVM)  procedure for pelvic organ prolapse ( POP) . From April 2007 to March 2009, a total of 42 patients, who reported having an active sex life preoperatively underwent TVM for POP. Female sexual function was evaluated with the self-reporting, multiple-domain Female Sexual Function Index  (FSFI) . We administered the FSFI to all of the patients before and at 3, 6, and 12 months after surgery. The mean age at surgery was 61.3�}7.1 years. Before the TVM surgery, the FSFI score was very low ( 12.5�}9.0) . The total FSFI score was improved significantly at 12 months after surgery ( 17.4�}7.7) . The Arousal, Lubrication and Orgasm domains were significantly improved at 12 months after surgery. POP appears to have a significant negative impact on female sexual function. Our findings indicate that TVM for POP improved sexual function in a group of Japanese women with POP.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoYuko
en-aut-sei=Matsumoto
en-aut-mei=Yuko
kn-aut-name=�¼–{—TŽq
kn-aut-sei=�¼–{
kn-aut-mei=—TŽq
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Urology, Okayama University Graduate School of Medicne, Dentistry and Pharmaceutical Sciences
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�@”å”AŠí•a‘ÔŠw
en-keyword=�œ”Õ‘ŸŠí’E (pelvic organ prolapse)
kn-keyword=�œ”Õ‘ŸŠí’E (pelvic organ prolapse)
en-keyword=TVM (tension-free vaginal mesh)
kn-keyword=TVM (tension-free vaginal mesh)
en-keyword=�—�«”å”AŠí‰È (female urology)
kn-keyword=�—�«”å”AŠí‰È (female urology)
en-keyword=�«‹@”\ (sexual function)
kn-keyword=�«‹@”\ (sexual function)
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=4
article-no=
start-page=261
end-page=268
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201608
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Diagnostic Algorithm for Eosinophilic Granulomatosis with Polyangiitis Initially Diagnosed as Lumbar Disc Hernia or Lumbar Spinal Stenosis: Personal Experience and Review of the Literature
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome) is a rare systemic vasculitis and is difficult to diagnose. EGPA has a number of symptoms including peripheral dysesthesia caused by mononeuropathy multiplex, which is similar to radiculopathy due to lumbar disc hernia or lumbar spinal stenosis. Therefore, EGPA patients with mononeuropathy multiplex often visit orthopedic clinics, but orthopedic doctors and spine neurosurgeons have limited experience in diagnosing EGPA because of its rarity. We report a consecutive series of patients who were initially diagnosed as having lumbar disc hernia or lumbar spinal stenosis by at least 2 medical institutions from March 2006 to April 2013 but whose final diagnosis was EGPA. All patients had past histories of asthma or eosinophilic pneumonia, and four out of five had peripheral edema. Laboratory data showed abnormally increased eosinophil counts, and nerve conduction studies of all patients revealed axonal damage patterns. All patients recovered from paralysis to a functional level after high-dose steroid treatment. We shortened the duration of diagnosis from 49 days to one day by adopting a diagnostic algorithm after experiencing the first case.
en-copyright=
kn-copyright=

en-aut-name=NagataKosei
en-aut-sei=Nagata
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoShinichi
en-aut-sei=Yamamoto
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyoshiKota
en-aut-sei=Miyoshi
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SatoMasaki
en-aut-sei=Sato
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ArinoYusuke
en-aut-sei=Arino
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MikamiYoji
en-aut-sei=Mikami
en-aut-mei=Yoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Yokohama Rosai Hospital
kn-affil=
en-keyword=eosinophilic granulomatosis with polyangiitis
kn-keyword=eosinophilic granulomatosis with polyangiitis
en-keyword=mononeuropathy multiplex
kn-keyword=mononeuropathy multiplex
en-keyword=lumbar disc hernia
kn-keyword=lumbar disc hernia
en-keyword=lumbar spinal stenosis
kn-keyword=lumbar spinal stenosis
en-keyword=nerve conduction study
kn-keyword=nerve conduction study
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=2
article-no=
start-page=95
end-page=97
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2015 Incentive Award of the Okayama Medical Association in Neuroscience (2015 Niimi Prize)
kn-title=•½�¬27”N“x‰ªŽRˆãŠw‰ï�Ü ”]�_ŒoŒ¤‹†�§—ã�Ü�i�VŒ©�Ü�j
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ToyoshimaAtsuhiko
en-aut-sei=Toyoshima
en-aut-mei=Atsuhiko
kn-aut-name=–L“ˆ“Ö•F
kn-aut-sei=–L“ˆ
kn-aut-mei=“Ö•F
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Okayama University Hospital
kn-affil=‰ªŽR‘åŠw•a‰@�@”]�_ŒoŠO‰È
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=1
article-no=
start-page=141
end-page=158
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201601
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Alternative approach for Siegel's lemma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this article, we present an alternative approach to show a generalization of Siegel's lemma which is an essential tool in Diophantine problems. Our main statement contains the so-called analytic Siegel's lemma as well as the Bombieri-Vaaler lemma. Our proof avoids relying on the ordinary geometry of numbers.
en-copyright=
kn-copyright=

en-aut-name=NagataMakoto
en-aut-sei=Nagata
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Osaka University of Pharmaceutical Sciences
en-keyword=Siegel�fs lemma
kn-keyword=Siegel�fs lemma
en-keyword=geometry of numbers
kn-keyword=geometry of numbers
en-keyword=height
kn-keyword=height
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=93
end-page=100
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150306
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Study of developing a teaching program for a voter education from an elementary school to a high school�@Based on developing a tentative lesson plan of an elementary social studies in order to teach about vote
kn-title=�¬’†�‚ˆêŠÑ—LŒ ŽÒ‹³ˆçƒvƒ�ƒOƒ‰ƒ€ŠJ”­‚Ì•û–@�i‚P�j:�u‘I‹“�v‚ðƒe�[ƒ}‚Æ‚·‚é�¬Šw�ZŽÐ‰ï‰È‚Ì’PŒ³‚ÌŠJ”­‚ð’Ê‚µ‚Ä
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=�@–{Œ¤‹†‚Í�CŽs–¯ŽÐ‰ï‚ÉŠñ—^‚µ“¾‚é—LŒ ŽÒ‚̈ç�¬‚ð–ÚŽw‚µ�CŽ™“¶�E�¶“k‚Ì”­’B’iŠK‚ɉž‚¶‚½—LŒ ŽÒ‹³ˆç‚Ì‚ ‚è•û
‚ð’Ç‹†‚µ‚Ä�C�¬Šw�Z‚©‚ç�‚“™Šw�Z‚Ü‚Å‚Ì12 ”NŠÔ‚ðˆêŠÑ‚·‚錴—�‚É‚à‚Ƃ¢‚½—LŒ ŽÒ‹³ˆçƒvƒ�ƒOƒ‰ƒ€ŠJ”­‚Ì‚½‚ß
‚ÌŒ´—�‚Æ•û–@‚ð‰ð–¾‚µ‚悤‚Æ‚·‚é‚à‚Ì‚Å‚ ‚é�B‚»‚Ì‚½‚ß‚É�C‘æˆê‚É�CŽq‚Ç‚à‚½‚¿‚Ì�­Ž¡‚ɑ΂·‚é”FŽ¯’²�¸‚ð�s‚¢�C
Žq‚Ç‚à‚½‚¿‚ª�­Ž¡“I‚ÈŠT”O‚ɂ‚¢‚Ăǂ̂悤‚È”FŽ¯‚ðŽ�‚Á‚Ä‚¨‚è�C‚»‚ê‚ð‹³ˆç‚É‚æ‚Á‚Ä‚Ç‚Ì’ö“x‚Ü‚Å•Ï—e‚³‚¹‚é
‚±‚Æ‚ª‚Å‚«‚é‚©‚𖾂炩‚É‚µ‚½�B‚»‚µ‚Ä�C‘æ“ñ‚É�C‚»‚Ì’²�¸‚ÌŒ‹‰Ê‚Æ�]—ˆ‚Ì�­Ž¡‹³ˆçŒ¤‹†‚Ì�¬‰Ê‚ð‚Ó‚Ü‚¦‚Ä�C—L
Œ ŽÒ‹³ˆç‚Ì‚½‚ß‚Ì�¬’†�‚ˆêŠÑƒJƒŠƒLƒ…ƒ‰ƒ€�EƒtƒŒ�[ƒ€ƒ��[ƒN‚ð’ñŽ¦‚µ‚½�B‚»‚ê‚ÉŠî‚¢‚Ä�C‘æŽO‚É�C‹ï‘Ì“I‚È’P
Œ³ŠJ”­‚ð�s‚Á‚½�B’PŒ³‚Í�C�u‘I‹“�v�C�u‹c‰ï�v�C�u�Å‹à�v‚Æ‚¢‚¤�­Ž¡Šw‚ÌŠî–{“IŠT”O‚ðƒe�[ƒ}‚Æ‚µ‚ÄŽæ‚è�ã‚°‚ÄŠJ”­
‚µ‚½‚ª�C–{�e‚Å‚Í�u‘I‹“�vŠT”O‚ðƒe�[ƒ}‚Æ‚µ‚ÄŠJ”­‚µ‚½�¬Šw�ZŽÐ‰ï‰È‚Ì’PŒ³‚ð�Љ‚é�B
en-copyright=
kn-copyright=

en-aut-name=KuwabaraToshinori
en-aut-sei=Kuwabara
en-aut-mei=Toshinori
kn-aut-name=ŒKŒ´•q“T
kn-aut-sei=ŒKŒ´
kn-aut-mei=•q“T
aut-affil-num=1
ORCID=

en-aut-name=KudoBunzo
en-aut-sei=Kudo
en-aut-mei=Bunzo
kn-aut-name=�H“¡•¶ŽO
kn-aut-sei=�H“¡
kn-aut-mei=•¶ŽO
aut-affil-num=2
ORCID=

en-aut-name=TanahashiKenji
en-aut-sei=Tanahashi
en-aut-mei=Kenji
kn-aut-name=’I‹´Œ’Ž¡
kn-aut-sei=’I‹´
kn-aut-mei=Œ’Ž¡
aut-affil-num=3
ORCID=

en-aut-name=YatabeReio
en-aut-sei=Yatabe
en-aut-mei=Reio
kn-aut-name=’J“c•”—æ�¶
kn-aut-sei=’J“c•”
kn-aut-mei=—æ�¶
aut-affil-num=4
ORCID=

en-aut-name=KoyamaShigeki
en-aut-sei=Koyama
en-aut-mei=Shigeki
kn-aut-name=�¬ŽR–Ίì
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kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È

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kn-affil=’é’ËŽRŠw‰@‘åŠw�lŠÔ‰ÈŠw•”

affil-num=3
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kn-affil=�L“‡‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È

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kn-affil=‹Ëˆü‰¡•l‘åŠw–@Šw•”

affil-num=5
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kn-affil=�M�B‘åŠw‘SŠw‹³ˆç‹@�\

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kn-affil=‹{�è‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È

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kn-affil=ˆ¤•Q‘åŠw‹³ˆçŠw•”

affil-num=8
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kn-affil=�L“‡‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È

affil-num=9
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kn-affil=•Ÿˆä‘åŠw‹³ˆç’nˆæ‰ÈŠw•”

affil-num=10
en-affil=
kn-affil=“Œ‹žŠwŒ|‘åŠw‹³ˆçŠw•”
en-keyword=—LŒ ŽÒ‹³ˆç
kn-keyword=—LŒ ŽÒ‹³ˆç
en-keyword=�¬’†�‚ˆêŠÑ
kn-keyword=�¬’†�‚ˆêŠÑ
en-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€�EƒtƒŒ�[ƒ€ƒ��[ƒN
kn-keyword=ƒJƒŠƒLƒ…ƒ‰ƒ€�EƒtƒŒ�[ƒ€ƒ��[ƒN
en-keyword=�¬Šw�ZŽÐ‰ï‰È
kn-keyword=�¬Šw�ZŽÐ‰ï‰È
en-keyword=’PŒ³ŠJ”­
kn-keyword=’PŒ³ŠJ”­
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start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=
article-no=
start-page=5
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=�DŽ_�«“SŽ_‰»�×‹Û Acidithiobacillus ferrooxidans ‚Ì�õ�F‘Ì‹Ã�W�E•ª”zƒ^ƒ“ƒpƒNŽ¿�iScpB�j‚Ì�«Ž¿
kn-title=Characterization of a putative chromosome segregation and condensation protein (ScpB) in an acidophilic iron?oxidizing bacterium Acidithiobacillus ferrooxidans
en-subtitle=
kn-subtitle=
en-abstract=�@Acidithiobacillus ferrooxidans ‚Í�C’á•iˆÊ‚Ì“º�z�΂©‚瓺‚ð‰ñŽû‚·‚éƒoƒCƒIƒŠ�[ƒ`ƒ“ƒO‚É‚¨‚¢‚ÄŽg—p‚³‚ê‚é”÷�¶•¨
‚̈ê‚‚ł ‚é�D‚±‚Ì�׋ۂÍ�CƒGƒlƒ‹ƒM�[Œ¹‚Æ‚µ‚Ä“ñ‰¿“SƒCƒIƒ“‚âŠÒŒ³Œ^–³‹@—°‰©‰»�‡•¨�iRISC�j‚ðŽg—p‚·‚é�D“S‚ÌŽ_‰»‚ÉŠÖ—^‚·‚éˆâ“`Žq‚Ì“]ŽÊ‚Í�CA. ferrooxidans ‚ª RISC ‚Å�¶ˆç‚µ‚½‚Æ‚«‚É‚Í—}�§‚³‚ê‚邪�CRISC ‚ÌŽ_‰»‚ÉŠÖ—^‚·‚é‚Æ�l‚¦‚ç‚ê‚Ä‚¢‚éˆâ“`Žq‚Ì“]ŽÊ‚ÍŠˆ�«‰»‚³‚ê‚邱‚Æ‚ª’m‚ç‚ê‚Ä‚¢‚é�D—°‰©‚âƒeƒgƒ‰ƒ`ƒIƒ“Ž_‚Å�¶ˆç‚µ‚½‚Æ‚«‚É‚»‚Ì”­Œ»‚ª�ã•û�§Œä‚³‚ê‚é—°‰»�…‘f�FƒLƒmƒ“Ž_‰»ŠÒŒ³�y‘f‚Ì‚·‚®�ã—¬‚É�CƒwƒŠƒbƒNƒXƒ^�[ƒ“‚ÖƒŠƒbƒNƒXƒ‚ƒeƒB�[ƒt‚ðŽ�‚Â�CScpB ‚Æ�„’肳‚ê‚éƒ^ƒ“ƒpƒNŽ¿‚ðƒR�[ƒh‚·‚éˆâ“`Žq‚ª‘¶�Ý‚µ‚Ä‚¢‚½�D“S�C—°‰©�Cƒeƒgƒ‰ƒ`ƒIƒ“Ž_�¶ˆç�×–E‚©‚ç’²�»‚µ‚½ cDNA ‚ð—p‚¢‚½”¼’è—Ê“I PCR •ª�Í‚ÌŒ‹‰Ê�C—°‰©‚âƒeƒgƒ‰ƒ`ƒIƒ“Ž_‚Å�¶ˆç‚µ‚½�×–E“à‚Ì scpB ˆâ“`Žq‚Ì“]ŽÊ‚Í�C“S�¶ˆç�×–E‚Æ”äŠr‚·‚é‚Æ�ã•û�§Œä‚³‚ê‚Ä‚¢‚½�D‘gŠ·‚¦ ScpB ƒ^ƒ“ƒpƒNŽ¿‚ð—p‚¢‚½ƒQƒ‹ƒVƒtƒgƒAƒbƒZƒC–@‚Å�CScpB
‚ª“]ŽÊ�§ŒäˆöŽq‚Æ‚µ‚Ä‹@”\‚·‚é‚©‚Ç‚¤‚©‚𒲂ׂ½�D‚»‚ÌŒ‹‰Ê�CScpB ‚Í DNA ‚ÉŒ‹�‡‚µ‚½‚ª�CŒ‹�‡‚Ì“ÁˆÙ�«‚Í‚È‚©‚Á‚½�DScpB ‚ª’¼�Ú DNA ‚Æ‘ŠŒÝ�ì—p‚·‚é•ñ��‚Í‚±‚ê‚Ü‚Å‚É‚È‚©‚Á‚½�D
kn-abstract=�@Acidithiobacillus ferrooxidans is one of the most widely used microorganisms in bioleaching operations to recover copper from low-grade copper sulfide. This bacterium uses ferrous iron and reduced inorganic sulfur compounds (RISCs) as energy sources. Transcriptions of genes thought to be involved in the oxidation of RISCs have been known to be highly activated in A. ferrooxidans cells grown on RISCs, while transcriptions of genes involved in the iron oxidation were repressed in the cells grown on
RISCs. A gene encoding a putative chromosome segregation and condensation protein (ScpB) with a
helix-turn-helix motif was found in the upstream region of sulfide : quinone oxidoreductase gene, whose expression was up-regulated in cells grown in sulfur and tetrathionate. A semi-quantitative PCR analysis using cDNA prepared from iron-, sulfur-, or tetrathionate-grown cells revealed that the transcription of scpB was up-regulated in cells grown on sulfur or tetrathionate as the energy source. Electrophoretic mobility shift assays were employed to examine whether the ScpB functions as a transcription factor. The result indicated that the recombinant His-tagged ScpB protein was able to nonspecifically bind in
vitro to DNA. This is the first report on a direct association of ScpB with DNA.
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en-aut-name=KamimuraKazuo
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en-aut-name=NagataNozomu
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en-aut-name=KikumotoMei
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en-aut-name=SharminSultana
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en-aut-name=WakaiSatoshi
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en-aut-name=KanaoTadayoshi
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affil-num=1
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kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«�¶–½‰ÈŠwŒ¤‹†‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«�¶–½‰ÈŠwŒ¤‹†‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«�¶–½‰ÈŠwŒ¤‹†‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«�¶–½‰ÈŠwŒ¤‹†‰È

affil-num=5
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kn-affil=�_ŒË‘åŠwŽ©‘R‰ÈŠwŒn�æ’[—Z�‡Œ¤‹†ŠÂ

affil-num=6
en-affil=
kn-affil=�_ŒË‘åŠwŽ©‘R‰ÈŠwŒn�æ’[—Z�‡Œ¤‹†ŠÂ
en-keyword=Acidithiobacillus ferrooxidans
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en-keyword=Acidophile
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en-keyword=ScpB
kn-keyword=ScpB
en-keyword=transcription factor
kn-keyword=transcription factor
END

start-ver=1.4
cd-journal=joma
no-vol=
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no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140325
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en-title=
kn-title=‘w�óŠó“y—Þ•¡“d‰×“SŽ_‰»•¨YbFe2O4’PŒ‹�»‚Ì“d‰×’��˜Œ`�¬‚É‚æ‚é‹­—U“d�«‚Æ‚»‚Ì‘Î�Ì�«
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en-aut-name=NagataTomoko
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kn-aut-name=‰i“c’mŽq
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affil-num=1
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kn-affil=‰ªŽR‘åŠw
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start-ver=1.4
cd-journal=joma
no-vol=155
cd-vols=
no-issue=
article-no=
start-page=109
end-page=113
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140225
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=Junior High School Female Teachers�f Negative Feelings and Embarrassment toward Dance
kn-title=’†Šw�Z�—�«‘̈狳ˆõ‚̃_ƒ“ƒX‚ɑ΂·‚é’ï�RŠ´‚Æãµ’p�S‚ɂ‚¢‚Ä
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en-aut-name=SakoHaruko
en-aut-sei=Sako
en-aut-mei=Haruko
kn-aut-name=ŽðŒüŽ¡Žq
kn-aut-sei=ŽðŒü
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en-aut-name=NagataMariko
en-aut-sei=Nagata
en-aut-mei=Mariko
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en-aut-name=IzakiYayoi
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affil-num=1
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affil-num=2
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kn-affil=‚¨’ƒ‚Ì�…�—Žq‘åŠw

affil-num=3
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kn-affil=‚¨’ƒ‚Ì�…�—Žq‘åŠw
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start-ver=1.4
cd-journal=joma
no-vol=154
cd-vols=
no-issue=
article-no=
start-page=73
end-page=77
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20131125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Gender Bias in the Dance Image of Junior High School Students
kn-title=’†Šw�¶‚̃_ƒ“ƒX‚ɑ΂·‚éƒWƒFƒ“ƒ_�[�EƒoƒCƒAƒX
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en-aut-name=SakoHaruko
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en-aut-mei=Haruko
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en-aut-name=NagataMariko
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en-aut-name=IdeharaChinami
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kn-aut-name=�oŒ´’q”g
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en-aut-name=YamaguchiJunko
en-aut-sei=Yamaguchi
en-aut-mei=Junko
kn-aut-name=ŽRŒû�‡Žq
kn-aut-sei=ŽRŒû
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en-aut-name=IzakiYayoi
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affil-num=1
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affil-num=2
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kn-affil=‚¨’ƒ‚Ì�…�—Žq‘åŠw

affil-num=3
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affil-num=4
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affil-num=5
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kn-affil=‚¨’ƒ‚Ì�…�—Žq‘åŠw
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kn-keyword=ƒ_ƒ“ƒX
en-keyword=ƒWƒFƒ“ƒ_�[�EƒCƒ��[ƒW
kn-keyword=ƒWƒFƒ“ƒ_�[�EƒCƒ��[ƒW
en-keyword=ƒWƒFƒ“ƒ_�[�EƒoƒCƒAƒX
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start-ver=1.4
cd-journal=joma
no-vol=153
cd-vols=
no-issue=
article-no=
start-page=97
end-page=102
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130725
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Sex Difference in Dance Image of Junior High School Students
kn-title=’†Šw�¶‚̃_ƒ“ƒX‚ɑ΂·‚éƒCƒ��[ƒW�\’j�—�·‚ÌŒŸ“¢�\
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en-abstract=
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en-aut-name=SakoHaruko
en-aut-sei=Sako
en-aut-mei=Haruko
kn-aut-name=ŽðŒüŽ¡Žq
kn-aut-sei=ŽðŒü
kn-aut-mei=Ž¡Žq
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ORCID=

en-aut-name=NagataMariko
en-aut-sei=Nagata
en-aut-mei=Mariko
kn-aut-name=‰i“c–ƒ—¢Žq
kn-aut-sei=‰i“c
kn-aut-mei=–ƒ—¢Žq
aut-affil-num=2
ORCID=

en-aut-name=IdeharaChinami
en-aut-sei=Idehara
en-aut-mei=Chinami
kn-aut-name=�oŒ´’q”g
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kn-aut-mei=’q”g
aut-affil-num=3
ORCID=

en-aut-name=MiyamotoOtome
en-aut-sei=Miyamoto
en-aut-mei=Otome
kn-aut-name=‹{–{‰³�—
kn-aut-sei=‹{–{
kn-aut-mei=‰³�—
aut-affil-num=4
ORCID=

en-aut-name=IzakiYayoi
en-aut-sei=Izaki
en-aut-mei=Yayoi
kn-aut-name=’–�è–í�¶
kn-aut-sei=’–�è
kn-aut-mei=–í�¶
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=
kn-affil=
en-keyword=ƒ_ƒ“ƒX
kn-keyword=ƒ_ƒ“ƒX
en-keyword=ƒWƒFƒ“ƒ_�[�EƒCƒ��[ƒW
kn-keyword=ƒWƒFƒ“ƒ_�[�EƒCƒ��[ƒW
en-keyword=ƒWƒFƒ“ƒ_�[�EƒoƒCƒAƒX
kn-keyword=ƒWƒFƒ“ƒ_�[�EƒoƒCƒAƒX
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start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=2
article-no=
start-page=139
end-page=143
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of strangulated ileus caused by internal hernia through a defect in the broad ligament of the uterus
kn-title=Žq‹{�LŠÔ–Œ—ô�Eƒwƒ‹ƒjƒA‚É‚æ‚é�i�N�«ƒCƒŒƒEƒX‚Ì‚P—á
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 41-year-old woman was admitted to our hospital because of lower abdominal pain. She had no history of laparotomy. An abdominal CT scan at the time of admission indicated closed-loop intestinal obstruction of the small intestine within the pelvis and deviation of the uterus to the right. We diagnosed this as a strangulated internal hernia and decided to conduct an emergency operation. The ileum had herniated through a defect in the broad ligament of the uterus. The strangulated intestinal loop, which was about 25cm long, was released, and the defect of the broad ligament was closed. The postoperative course was uneventful. The differential diagnosis of intestinal obstruction should include internal hernia, especially in the absence of a previous laparotomy. An abdominal CT scan is quite useful for the preoperative and prompt diagnosis of internal hernia through a defect in the broad ligament of the uterus.
en-copyright=
kn-copyright=

en-aut-name=HaisaMinoru
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en-title=The treatment strategy for clinical stage III non-small cell lung cancer
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en-title=Gender Bias in Dance of Teachers and Junior High School's Students
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en-title=Current status of transplantation for diabetes mellitus
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en-aut-name=NoguchiHirofumi
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en-aut-name=FujiwaraToshiyoshi
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affil-num=1
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en-title=
kn-title=Scanning and non-scanning surface plasmon microscopy to observe cell adhesion sites
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en-abstract=
kn-abstract=We observe adhesion sites of a cell on a substrate with high resolution. Since this observation requires interfacial measurements between the cell and the substrate, we employ scanning localized surface plasmon microscopy. We experimentally show that focal adhesion sites of a mouse muscle cell can be observed without fluorescent labeling. We also show that a non-scanning surface plasmon microscope combined with the scanning localized surface plasmon microscope contributes to observing an entire cell adhesion site and identify regions of interest.
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en-aut-name=WatanabeKoyo
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en-aut-name=MatsuuraKoji
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en-aut-name=KawataFukukazu
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en-aut-name=NagataKotaro
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en-aut-name=NingJun
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en-aut-name=KanoHiroshi
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affil-num=1
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Research Core for Interdisciplinary Sciences, Okayama University

affil-num=3
en-affil=
kn-affil=Division of Information and Electronic Engineering, Graduate School of Engineering, Muroran Institute of Technology

affil-num=4
en-affil=
kn-affil=Division of Information and Electronic Engineering, Graduate School of Engineering, Muroran Institute of Technology

affil-num=5
en-affil=
kn-affil=Division of Engineering for Composite Functions, Graduate School of Engineering, Muroran Institute of Technology

affil-num=6
en-affil=
kn-affil=Division of Engineering for Composite Functions, Graduate School of Engineering, Muroran Institute of Technology
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start-ver=1.4
cd-journal=joma
no-vol=124
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article-no=
start-page=129
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dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
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kn-subject=
en-title=Antibacterial efficacy of photocatalytic reaction on titanium dioxide-coated ceramic air filters
kn-title=Ž_‰»ƒ`ƒ^ƒ“’SŽ�ƒZƒ‰ƒ~ƒbƒNƒtƒBƒ‹ƒ^�[‚ÌŒõ�G”}”½‰ž‚É‚æ‚é�R‹ÛŒø‰Ê‚ÌŒŸ“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Titanium dioxide (TiO<sub>2</sub>) photocatalysis generates reactive oxygen species such as �EOH and �EO<sub>2</sub>-, which can effectively eliminate organic compounds. In the present study, we evaluated the antibacterial and antifungal effects of TiO<sub>2</sub>-coated ceramic air filters in both laboratory and hospital settings. Photocatalysis with the TiO<sub>2</sub>-coated ceramic filter effectively inactivated all 4 pathogenic organisms tested. Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. After the photocatalysis reaction for 4 h under UV-A (365nm, 250ƒÊW/?) irradiation, the percentage reductions of the number of E. coli, P. aeruginosa, S. aureus, C. albicans cells were 99.9%, 98.9%, 97.7% and 99.9%, respectively, indicating that Gram-negative bacteria are more susceptible to such photocatalysis than Gram-positive bacteria. Scanning electron microscopic analysis showed damage to the cytoplasmic membrane and cell wall by photocatalysis : consistent with above observations, the morphological change of Gram-negative E. coli was greater than that of Gram-positive S. aureus. �@Further, an air cleaner equipped with a TiO<sub>2</sub>-coated ceramic filter significantly decreased the number of bacteria floating in hospitals. �@These results indicate that air cleaners with TiO<sub>2</sub>-coated ceramic filters could be useful in reducing the incidence of nosocomial infections.
en-copyright=
kn-copyright=

en-aut-name=NakaoMiyuki
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affil-num=1
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en-keyword=Œõ�G”}�iphotocatalysis�j
kn-keyword=Œõ�G”}�iphotocatalysis�j
en-keyword=Ž_‰»ƒ`ƒ^ƒ“’SŽ�ƒZƒ‰ƒ~ƒbƒNƒtƒBƒ‹ƒ^�[�iTiO<sub>2</sub>-coated ceramic air filters�j
kn-keyword=Ž_‰»ƒ`ƒ^ƒ“’SŽ�ƒZƒ‰ƒ~ƒbƒNƒtƒBƒ‹ƒ^�[�iTiO<sub>2</sub>-coated ceramic air filters�j
en-keyword=�R‹ÛŒø‰Ê�iantimicrobial effect�j
kn-keyword=�R‹ÛŒø‰Ê�iantimicrobial effect�j
en-keyword=‰@“àŠ´�õ�inosocomial infection�j
kn-keyword=‰@“àŠ´�õ�inosocomial infection�j
en-keyword=‹ó‹C�´�ò‹@�iair cleaner�j
kn-keyword=‹ó‹C�´�ò‹@�iair cleaner�j
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cd-journal=joma
no-vol=23
cd-vols=
no-issue=3
article-no=
start-page=19
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=19911216
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Invalidity of the Simultaneous Confidence Interval Corresponding to the Step-down Procedure under the Multiple Comparison
kn-title=‘½�d”äŠr‚É‚¨‚¯‚鉺�~Žè�‡‚ɑΉž‚·‚铯Žž�M—Š‹æŠÔ‚Ì”ñ‘Ó–�«‚ɂ‚¢‚Ä‚Ì�lŽ@
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=‰i“c–õ
kn-aut-sei=‰i“c
kn-aut-mei=–õ
aut-affil-num=1
ORCID=

en-aut-name=MatsudaShin-ichi
en-aut-sei=Matsuda
en-aut-mei=Shin-ichi
kn-aut-name=�¼“cáÁˆê
kn-aut-sei=�¼“c
kn-aut-mei=áÁˆê
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=“ìŽR‘åŠwŒo‰cŠw•”�î•ñŠÇ—�Šw‰È
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start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=4
article-no=
start-page=301
end-page=314
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=19940310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Approximation Formulas for the Lower Confidence Limits of Process Capability Indices
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=‰i“c–õ
kn-aut-sei=‰i“c
kn-aut-mei=–õ
aut-affil-num=1
ORCID=

en-aut-name=NagahataHidekazu
en-aut-sei=Nagahata
en-aut-mei=Hidekazu
kn-aut-name=’·”¨�G˜a
kn-aut-sei=’·”¨
kn-aut-mei=�G˜a
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Faculty of Economics, Okayama University

affil-num=2
en-affil=
kn-affil=Faculty of Education, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=3-4
article-no=
start-page=325
end-page=339
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19950310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=POINT ESTIMATION OF THE PROCESS CAPABILITY INDEX C(pk)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper point estimation of the process capability index C(pk) is considered. In order to improve on the natural estimator, a simple alternative estimator is proposed and its mean square error is evaluated numerically.
en-copyright=
kn-copyright=

en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=‰i“c–õ
kn-aut-sei=‰i“c
kn-aut-mei=–õ
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Faculty of Economics, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=4
article-no=
start-page=293
end-page=316
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Stein Type Confidence Interval of the Disturbance Variance in a Linear Regression Model
kn-title=‰ñ‹A•ª�Í‚É‚¨‚¯‚éŒë�·•ªŽU‚̃Xƒ^ƒCƒ“Œ^‰ü—Ç�M—Š‹æŠÔ‚Ì�”�«Ž¿
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper the interval estimation of the disturbance variance in a linear regression model is discussed from several view points. Firstly, a brief summary ofthe Stein type point estimation theory and the Stein type interval estimation theory is given. Then, the relationship between the improvement on the point estimation and the improvement on the interval estimation is discussed. It is shown that substituting the Stein type estimator for the usual estimator in the confidence interval leads to the improvement on the interval estimation. Secondly, the Neyman accuracy of the Stein type confidence interval
is considered. The Neyman accuracy is a measure related to the unbiasedness of a confidence interval. It is shown that the Stein type confidence interval is not unbiased. Thirdly, the Wolfowitz accuracy of the Stein type confidence interval is considered. The Wolfowitz accuracy is related to the closeness of the endpoints to. the true parameter. The sufficient condition for the Stein type confidence interval to improve on the usual confidence interval is derived. Finally, the Stein type confidence interval is discussed under the multivariate Student-t distribution. It is shown that so far as the coverage probability and the multivariate Student-t distributions are concerned, the Stein type confidence interval is not robust against nonnormality, but that the superiority over the usual confidence interval still holds against nonnormality. Furthermore, for the case when it is known that error terms have a multivariate Student-t distribution, a Stein type confidence interval which improves on the usual confidence interval is presented.
en-copyright=
kn-copyright=

en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=‰i“c–õ
kn-aut-sei=‰i“c
kn-aut-mei=–õ
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=3
article-no=
start-page=271
end-page=280
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=19990310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Optimality of the Stein Type Confidence Interval of Variance
kn-title=Œë�·•ªŽU‚̃Xƒ^ƒCƒ“Œ^‰ü—Ç�M—Š‹æŠÔ‚Ì�Å“K�«‚ɂ‚¢‚Ä
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper the optimality of the Stein type confidence interval of the disturbance variance among the class of pre-test confidence interval after the pre-test for a linear hypothesis on coefficients is considered. The Stein type confidence interval is a member in the class with a critical value, say c. It is known that the Stein type confidence interval is the best in the subclass which consists of the pre-test confidence intervals with a smaller critical value than c. It is shown that an extension of the optimality to a larger class is not possible.
en-copyright=
kn-copyright=

en-aut-name=NagataYasushi
en-aut-sei=Nagata
en-aut-mei=Yasushi
kn-aut-name=‰i“c–õ
kn-aut-sei=‰i“c
kn-aut-mei=–õ
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=32
cd-vols=
no-issue=1
article-no=
start-page=57
end-page=68
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20000610
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Assimilation Effect in Judging the Grammaticality of Sentences Violating the Subjacency Condition: A Further Exploration
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study explored an assimilation effect in judging the grammaticality of sentences violating the subjacency condition. The target sentences included either a noun phrase (NP-extracted) or an
adverbial phrase (AP-extracted), each extracted from a subordinate clause and placed in front of the sentences. Anchor sentences had a surface structure similar to the AP-extracted targets such that a preposed adverbial phrase could be associated both with the subordinate
and the matrix verb. Twenty-eight speakers classified as field-dependent judged the two types oftarget sentences given together with anchors or no anchors. The assimilation as well as the contrast effect was found, albeit
to a slight degree. The level of judged grammaticality of the anchors rather than surface structure similarity appeared to be more influential in producing the anchoring effects in the judgments of the grammaticality of sentences.
en-copyright=
kn-copyright=

en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Faculty of Economics, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=2
article-no=
start-page=25
end-page=34
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=20010910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Japanese speakers�f judgments of grammaticality of Japanese and English bitransitive sentences with a differing number of arguments : A comparison between speakers exposed to Chomsky�fs generative grammar and those not
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigates the judgments of grammaticality of Japanese and English bitransitive sentences with a differing number of arguments. Japanese speakers exposed to Chomsky�fs generative grammar (n = 30) and those not exposed (n = 28) were compared. This exposure was expected to facilitate a sentence? oriented
judgment strategy that would direct speakers towards decreasing the grammaticality of the Japanese sentences lacking one or more arguments. Findings showed no effect in the judgments of Japanese sentences. However, in the judgments of the English sentences speakers exposed to generative grammar approximated to those made by
native speakers of English. It was suggested that the exposure to generative grammar facilitated the sentence?oriented strategy in the judgments of English sentences, but it was not so effective as to weaken a discourse?oriented strategy used by Japanese speakers when they judged Japanese sentences.
en-copyright=
kn-copyright=

en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=1
article-no=
start-page=37
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=199901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Nagata Criterion for Serre's (Rn) and (Sn)-Conditions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakahashiRyo
en-aut-sei=Takahashi
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=3
article-no=
start-page=209
end-page=214
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1976
dt-pub=197606
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An extremely basic monoclonal IgG in an aged apoplectic patient with prolonged bacterial infection
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>A case with prolonged bacterial infection accompanied by an abnormal serum protein which migrated in the post-gamma region on electrophoresis is presented. The abnormal protein was identified as IgG with gamma-type light chain moiety. The patient suffered from prolonged pneumonia and cholecystitis, Bone marrow aspiration and skeletal x-rays did not indicate multiple myeloma.</p>

en-copyright=
kn-copyright=

en-aut-name=ArimaTerukatsu
en-aut-sei=Arima
en-aut-mei=Terukatsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TsuboiShuhei
en-aut-sei=Tsuboi
en-aut-mei=Shuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NagataKowichi
en-aut-sei=Nagata
en-aut-mei=Kowichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=GyotenYozo
en-aut-sei=Gyoten
en-aut-mei=Yozo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TanigawaTakashi
en-aut-sei=Tanigawa
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ImaiMasanobu
en-aut-sei=Imai
en-aut-mei=Masanobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KitaShowichi
en-aut-sei=Kita
en-aut-mei=Showichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Mitoyo General Hospital

affil-num=3
en-affil=
kn-affil=Mitoyo General Hospital

affil-num=4
en-affil=
kn-affil=Mitoyo General Hospital

affil-num=5
en-affil=
kn-affil=Mitoyo General Hospital

affil-num=6
en-affil=
kn-affil=Mitoyo General Hospital

affil-num=7
en-affil=
kn-affil=Okayama University 
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=5
article-no=
start-page=271
end-page=278
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=199810
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Nursing practitioners' perception of inpatients' anxiety, self-esteem, purpose-in-life and health locus of control.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>Nursing practitioners' perception of inpatients' anxiety, self-esteem, purpose-in-life and health locus of control.</p>

en-copyright=
kn-copyright=

en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhtaTakeo
en-aut-sei=Ohta
en-aut-mei=Takeo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AoyamaHideyasu
en-aut-sei=Aoyama
en-aut-mei=Hideyasu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama  University

affil-num=2
en-affil=
kn-affil=Okayama  University

affil-num=3
en-affil=
kn-affil=Okayama Univeristy
en-keyword=inpatient's mental health
kn-keyword=inpatient's mental health
en-keyword=anxiety
kn-keyword=anxiety
en-keyword=self-es-teem
kn-keyword=self-es-teem
en-keyword=purpose-in-life
kn-keyword=purpose-in-life
en-keyword=health locus of control
kn-keyword=health locus of control
END

start-ver=1.4
cd-journal=joma
no-vol=38
cd-vols=
no-issue=5
article-no=
start-page=461
end-page=469
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=198410
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Quantitative analysis of the production of heat-labile enterotoxin by enterotoxigenic Escherichia coli.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>A modified method of passive immune hemolysis (PIH) was applied to the quantitative assay of heat-labile enterotoxin (LT) produced by enterotoxigenic Escherichia coli. The method enabled the measurement of 0.2 to 1.2 ng LT. The production of LT by enterotoxigenic E. coli under various conditions was analyzed using the modified method. LT production was intense during the logarithmic growth phase and decreased during the stationary growth phase. Lincomycin (50 to 100 micrograms/ml) affected cell growth slightly, but enhanced production of LT until the late-stationary growth phase. About 90% of the LT produced was retained in the cell, and the rest was excreted into the culture medium. The initial pH of the culture medium affected LT production. Alkaline pH enhanced LT production, though growth was depressed. Aeration enhanced both growth and LT production.</p>

en-copyright=
kn-copyright=

en-aut-name=MinamiJunzabro
en-aut-sei=Minami
en-aut-mei=Junzabro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkabeAkinobu
en-aut-sei=Okabe
en-aut-mei=Akinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NagataAkihide
en-aut-sei=Nagata
en-aut-mei=Akihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HayashiHideo
en-aut-sei=Hayashi
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Kagawa Medical School

affil-num=2
en-affil=
kn-affil=Kagawa Medical School

affil-num=3
en-affil=
kn-affil=Okayama Univeristy

affil-num=4
en-affil=
kn-affil=Kagawa Medical School
en-keyword=heat-labile enterotoxin
kn-keyword=heat-labile enterotoxin
en-keyword=E
kn-keyword=E
en-keyword=coli
kn-keyword=coli
en-keyword=passive immune hemolysis
kn-keyword=passive immune hemolysis
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=284
end-page=289
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Extended ISM for Globally Multimodal Function Optimization by Genetic Algorithms
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=When attempting to optimize a function where exists several big-valley structures, conventional GAs often fail to find the global optimum. Innately Split Model (ISM) is a framework of GAs, which is designed to avoid this phenomenon called UV-Phenomenon. However, ISM doesn't care about previously-searched areas by the past populations. Thus, it is possible that populations of ISM waste evaluation cost for redundant searches reaching previously-found optima. In this paper, we introduce Extended ISM (EISM) that uses search information of past populations as trap to suppress overlapping searches. To show performance of EISM, we apply it to some test functions, and analyze the behavior.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KaratsuNaoya
kn-aut-sei=Karatsu
kn-aut-mei=Naoya
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=NagataYuichi
kn-aut-sei=Nagata
kn-aut-mei=Yuichi
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OnoIsao
kn-aut-sei=Ono
kn-aut-mei=Isao
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KobayashiShigenobu
kn-aut-sei=Kobayashi
kn-aut-mei=Shigenobu
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Tokyo Institute of Technology

affil-num=2
en-affil=
kn-affil=Tokyo Institute of Technology

affil-num=3
en-affil=
kn-affil=Tokyo Institute of Technology

affil-num=4
en-affil=
kn-affil=Tokyo Institute of Technology
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=
article-no=
start-page=31
end-page=55
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=‘æ4�Í�@—ðŽjŠwŒ¤‹†‚̈ꕪ�Í—vˆö‚Æ‚µ‚Ä�u‹CŒó�v‚ðŽæ‚è�ž‚Þ‚±‚Ƃ͉”\‚©�H �\ƒˆ�[ƒ�ƒbƒp‹ß�¢�ƒ�¬•XŠúLittle Ice Age�„‚Ì�ê�‡�\
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NagataRiyouichi
en-aut-sei=Nagata
en-aut-mei=Riyouichi
kn-aut-name=‰i“c—Ȉê
kn-aut-sei=‰i“c
kn-aut-mei=—Ȉê
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw
END

start-ver=1.4
cd-journal=joma
no-vol=80
cd-vols=
no-issue=1-2
article-no=
start-page=135
end-page=141
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1968
dt-pub=19680228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Report of a Case of Nasopharyngeal Tumor
kn-title=•@ˆô�oŒ´”­ˆ«�«Žîᇂ̈ê—á
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper is to report a case of naeopharyngeal tumor. The patient was a 57 years old man admitted to this hospital with chief complaints of impaired hearing and headache. The diagnosis had not been made until the biopsy of the enlarged lymphnode in the right neck was performed and histologically examined. The patient died in spits of radiation therapy with (60)Co over the neck. Postmortem examination revealed undifferentiated cell carcinoma in sphenoethomoidal sinus and its metastasis to the liver, lumbar vertebrae, and lymphnodes of various area. Studies on 41 cases of nasopharyngeal tumor experienced in the department of Otorhinopharyngol-aryngology of this University in recent 10 years (1957-1966) showed that a large number of the patient as much as 24% of the cases, first visited the clinic of internal medicine of examination of enlarged lymphnodes in the neck or headache.
en-copyright=
kn-copyright=

en-aut-name=MiyazakiTakeshi
en-aut-sei=Miyazaki
en-aut-mei=Takeshi
kn-aut-name=‹{�茒Žj
kn-aut-sei=‹{�è
kn-aut-mei=Œ’Žj
aut-affil-num=1
ORCID=

en-aut-name=NagataKoichi
en-aut-sei=Nagata
en-aut-mei=Koichi
kn-aut-name=‰i“c�kˆê
kn-aut-sei=‰i“c
kn-aut-mei=�kˆê
aut-affil-num=2
ORCID=

en-aut-name=OkutomiZenkichi
en-aut-sei=Okutomi
en-aut-mei=Zenkichi
kn-aut-name=‰œ•x‘P‹g
kn-aut-sei=‰œ•x
kn-aut-mei=‘P‹g
aut-affil-num=3
ORCID=

en-aut-name=YumotoYasuhiro
en-aut-sei=Yumoto
en-aut-mei=Yasuhiro
kn-aut-name=“’–{‘×�O
kn-aut-sei=“’–{
kn-aut-mei=‘×�O
aut-affil-num=4
ORCID=

en-aut-name=OtsukiHiroshi
en-aut-sei=Otsuki
en-aut-mei=Hiroshi
kn-aut-name=‘åžK—SŽ¡
kn-aut-sei=‘åžK
kn-aut-mei=—SŽ¡
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰È‹³Žº

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰È‹³Žº

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰È‹³Žº

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰È‹³Žº

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰È‹³Žº
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1309
end-page=1317
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of the standard total coli-form MPN test for the biological examination of water pollution
kn-title=‘å’°‹ÛŒQ‘ª’è–@‚Ì�…Ž¿‰˜�õŽw•W�«‚ÌŒŸ“¢
en-subtitle=
kn-subtitle=
en-abstract=The standard total coli-form MPN test is widely used as a biological indicator of water pollution. But our applications of the test to various field works resulted in much higher cell numbers than be expected. The reason can be thought to be that bacteria belonging to coliform group do not always derived from human and animal feces. In order to examine this possibility, the authors carried out the isolation and identification of bacteria which were detected by this method from various kinds of specimens. The result indicated that the bacteria designated as coli-form group included not only human- and animal-derived bacteria but also bacterial species which apparently derived from plants, soil or water, e.g. Erwinia, Aeromonas, Serratia, Citrobacter and so forth. Therefore, a method is demanded by which one can estimate quantitatively only bacteria associated with human and animal feces.
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affil-num=3
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affil-num=5
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kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=6
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kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=7
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kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=8
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kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=9
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kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=10
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kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®—Õ�°ŒŸ�¸‹ZŽtŠw�Z

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kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=12
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kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº
END

start-ver=1.4
cd-journal=joma
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start-page=215
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091201
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en-article=
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en-subject=
kn-subject=
en-title=Extremely high-quality radiation therapy
kn-title=�‚�¸“x•úŽË�üŽ¡—Ã
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en-aut-name=KatsuiKuniaki
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en-aut-name=TakemotoMitsuhiro
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en-aut-name=KanazawaSusumu
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affil-num=1
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kn-affil=‰ªŽR‘åŠw•a‰@�@•úŽË�ü‰È

affil-num=2
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kn-affil=‰ªŽR‘åŠw•a‰@�@•úŽË�ü‰È

affil-num=3
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kn-affil=‰ªŽR‘åŠw•a‰@�@•úŽË�ü‰È
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start-ver=1.4
cd-journal=joma
no-vol=96
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no-issue=7-8
article-no=
start-page=767
end-page=777
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19840830
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=Effect of heat-labile enterotoxin from enterotoxigenic Escherichia coli on the structure of rabbit intestinal epitherial cell and the brush border
kn-title=“Å‘fŒ´�«‘å’°‹Û‚ªŽY�¶‚·‚éˆÕ”M�«ƒGƒ“ƒeƒ�ƒgƒLƒVƒ“‚Ì�¬’°ãO–Ñ�ã”ç�×–E–Œ‚ɑ΂·‚é�ì—p
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Heat-labile enterotoxin produced by enterotoxigenic E. coli affected the structure of epitherial cell of rabbit intestine. The toxin bound to the microbilli of the cell and caused "puffing" of the microvillous membrane when it was examined under phasecontrast microscopy. The same change occured by the isolated brush border membrane if it was reacted with the enterotoxin in the presence of ATP. Electronmicroscopic observation disclosed that the bundle fibrous structure of the brush border was deformed to random structure and that some parts of the fibrous bundle detached from microvillous membrane. Since the enterotoxin bound to microvilli, it was suggested that cytoskelton including actin and myosin system of the cell could be affected through cAMP of which synthesis was activated at the microvilli membrane by the enterotoxin.
en-copyright=
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affil-num=1
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kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº
en-keyword=“Å‘fŒ´�«‘å’°‹Û
kn-keyword=“Å‘fŒ´�«‘å’°‹Û
en-keyword=ƒGƒ“ƒeƒ�ƒgƒLƒVƒ“
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END

start-ver=1.4
cd-journal=joma
no-vol=95
cd-vols=
no-issue=1-2
article-no=
start-page=35
end-page=40
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19830228
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=Identification of sphingoglycolipids in a patient regarded as having Fabry's disease.
kn-title=ƒtƒ@ƒuƒŠ�[•a‚ð‹^‚í‚ê‚éˆê�Ç—á‚Ì�¶‰»Šw“I“¯’è‚ɂ‚¢‚Ä
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fabry's disease is one of the inherited diseases, in which sphingoglycolipids accumulate systemically in tissue as the result of defective ƒ¿-galactosyl hydrolase. In this paper, we studied a 54 year-old female who had complaints of leg pain, palpebral edema and telangiectasis and in whom foam cells in renal biopsy as well as proteinuria in urinalysis were revealed. As an increase of sphingoglycolipids was discovered in her urinary sediment by biochemical analysis, this patient was shown to be suffering from Fabry's disease.
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en-aut-name=KiguchiKenichiro
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en-aut-name=NagataAkihide
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en-aut-name=KariyamaReiko
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en-aut-name=HiraiYoshikazu
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en-aut-name=KobayashiJun
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affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�׋ۊw‹³Žº

affil-num=7
en-affil=
kn-affil=‰ªŽR‹¦—§•a‰@
en-keyword=Fabry's disease
kn-keyword=Fabry's disease
en-keyword=Lipidosis
kn-keyword=Lipidosis
en-keyword=Hexosyl ceramide
kn-keyword=Hexosyl ceramide
en-keyword=Hereditary disease
kn-keyword=Hereditary disease
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=2
article-no=
start-page=129
end-page=134
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Differences in interpersonal values for three cohorts of new nursing students
kn-title=ŠÅŒìŠw�¶‚É‚¨‚¯‚é‘Î�lŠÖŒW‰¿’l‚̃Rƒz�[ƒg‚É‚æ‚é‘Šˆá
en-subtitle=
kn-subtitle=
en-abstract=KG-SIV (Kikuchi-Gordon Survey of Interpersonal Values) was administered twice to three cohorts of new nursing students admitted to School of Health Sciences, Okayama University, respectively, in 1990, 1993, and 1996. For the first testing, they indicated the values that were important to them, while for the second they indicated those that were important to an ideal nurse they had in their mind. Analyses showed that perceived values of Support and Independence increased while those of Benevolence decreased with the admission years. They also showed a reduced level of aspiration for an ideal nurse, particularly in 1996. Findings were discussed as they
were related with a socialization process that nursing students would undertake in prospective nurse training.
kn-abstract=ˆã—Ã’Z‘å“üŠw”N(1990”N,1993”N,1996”N)‚É‚¨‚¢‚ĈقȂéƒRƒz�[ƒg‚ð‚È‚·ŠÅŒìŠw�¶‚Ì‘Î�lŠÖŒW‰¿’l‚ð“üŠw’¼Œã‚ÉŽ©ŒÈ‘œ‚Æ—�‘z‚̃i�[ƒX‘œ‚ɂ‚¢‚ÄKG-SIV(Kikuchi-Gordon Survey of Interpersonal Values)‚É‚æ‚Á‚Ä‘ª’肵‚½¡‚»‚ÌŒ‹‰Ê,Ž©ŒÈ‘œ•]’è‚Å‚Í“üŠw”N‚ª�i‚ނɂ‚ê‚Ä¢ŽxŽ�£‚⢓Ɨ§£‚̉¿’l‚ð�dŽ‹‚·‚éŒXŒü‚ª‘�‘å‚·‚é‚̂ɑ΂µ,¢”Žˆ¤£‚̉¿’l‚Í‹t‚É�dŽ‹‚³‚ê‚È‚¢ŒXŒü‚ªŒ©‚¢‚¾‚³‚ꂽ¡‚Ü‚½,“Á‚É1996”N‚Å‚Í—�‘z‚̃i�[ƒX‘œ‚ɑ΂·‚é—v‹��…�€‚ª’á‚­‚Ȃ邱‚Æ‚à–¾‚ç‚©‚É‚È‚Á‚½¡‚±‚ÌŒ‹‰Ê‚ðŠÅŒìŠw�¶‚̎Љ‰ß’ö‚ÆŠÖ˜A‚¯‚Ä�lŽ@‚µ‚½¡
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en-aut-name=NagataHiroshi
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affil-num=1
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kn-affil=‰ªŽR‘åŠwˆã—ËZ�p’ZŠú‘åŠw•”

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆã—ËZ�p’ZŠú‘åŠw•”

affil-num=3
en-affil=
kn-affil=���쌧Œ’�N–¯�¶•”

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆã—ËZ�p’ZŠú‘åŠw•”
en-keyword=‘Î�lŠÖŒW‰¿’l (interpersonal values)
kn-keyword=‘Î�lŠÖŒW‰¿’l (interpersonal values)
en-keyword=ŠÅŒìŠw�¶ (nursing students)
kn-keyword=ŠÅŒìŠw�¶ (nursing students)
en-keyword=ƒRƒz�[ƒg (cohorts)
kn-keyword=ƒRƒz�[ƒg (cohorts)
en-keyword=ŽÐ‰ï‰» (socialization)
kn-keyword=ŽÐ‰ï‰» (socialization)
END

start-ver=1.4
cd-journal=joma
no-vol=121
cd-vols=
no-issue=2
article-no=
start-page=85
end-page=90
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090803
dt-online=
en-article=
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kn-subject=
en-title=CRTH2 plays an essential role in the pathophysiology of Cry j 1 -induced pollinosis in mice
kn-title=ƒ}ƒEƒXƒXƒM‰Ô•²�ǃ‚ƒfƒ‹‚É‚¨‚¯‚é CRTH2‚Ì–ðŠ„
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en-abstract=
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en-aut-name=NomiyaRie
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kn-aut-mei=—�Œb
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en-aut-name=OkanoMitsuhiro
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en-aut-mei=Mitsuhiro
kn-aut-name=‰ª–ìŒõ”Ž
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kn-aut-mei=Œõ”Ž
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en-aut-name=FujiwaraTazuko
en-aut-sei=Fujiwara
en-aut-mei=Tazuko
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en-aut-name=NishizakiKazunori
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kn-aut-mei=˜a‘¥
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affil-num=1
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kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�@Ž¨•@ˆô�A�E“ªèò•”ŠO‰ÈŠw

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�@Ž¨•@ˆô�A�E“ªèò•”ŠO‰ÈŠw

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�@Ž¨•@ˆô�A�E“ªèò•”ŠO‰ÈŠw

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�@Ž¨•@ˆô�A�E“ªèò•”ŠO‰ÈŠw
en-keyword=ƒXƒM‰Ô•²�Ç
kn-keyword=ƒXƒM‰Ô•²�Ç
en-keyword=ƒ‚ƒfƒ‹ƒ}ƒEƒX
kn-keyword=ƒ‚ƒfƒ‹ƒ}ƒEƒX
en-keyword=ƒvƒ�ƒXƒ^ƒOƒ‰ƒ“ƒWƒ“D(2)
kn-keyword=ƒvƒ�ƒXƒ^ƒOƒ‰ƒ“ƒWƒ“D(2)
en-keyword=CRTH(2)
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start-ver=1.4
cd-journal=joma
no-vol=121
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no-issue=1
article-no=
start-page=9
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Spa therapy as pulmonary rehabilitation for chronic obstructive pulmonary disease
kn-title=–��«•Â�Ç�«”xŽ¾Š³‚É‚¨‚¯‚éŒÄ‹zƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‚Æ‚µ‚Ẳ·�ò—Ö@
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en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

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en-aut-mei=Fumihiro
kn-aut-name=Œõ‰„•¶—T
kn-aut-sei=Œõ‰„
kn-aut-mei=•¶—T
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�@˜V”NˆãŠw
en-keyword=–��«•Â�Ç�«”xŽ¾Š³
kn-keyword=–��«•Â�Ç�«”xŽ¾Š³
en-keyword=ŒÄ‹zƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“
kn-keyword=ŒÄ‹zƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“
en-keyword=‰·�ò—Ö@
kn-keyword=‰·�ò—Ö@
en-keyword=”x‹@”\
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en-keyword=�‚•ª‰ð”\CT
kn-keyword=�‚•ª‰ð”\CT
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start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=73
end-page=94
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On climatology in Misasa spa (twenty-fifrh report)
kn-title=ŽO’©‰·�ò’n‚Ì‹CŒó‚ɂ‚¢‚Ä(‘æ25•ñ�j
en-subtitle=
kn-subtitle=
en-abstract=Climatological data ofthe last 12 months (2002. 1. 1.- 2002. 12. 31) obtained by the climate autorecording system at the Misasa Medical Branch in Misasa Spa, Tottori-ken, Japan are presented.
kn-abstract=‰ä�X‚Í1956”NˆÈ�~,ŽO’©‰·�ò’n‚Ì‹CŒó‚ɂ‚¢‚ÄŠÏŽ@‚ð�s‚Á‚Ä‚¢‚é¡�¡‰ñ‚Í2002”N1ŒŽ1“ú‚©‚ç2002”N12ŒŽ––“ú‚Ü‚Å‚Ì1”NŠÔ‚Ì‹C�ÛŠÏŽ@Ž‘—¿‚ð•ñ
��‚·‚é¡‹@Ší‚ÌŒÌ�á‚É‚æ‚è,Œ‡—Ž•”•ª‚ª‘½�X‚ ‚邱‚Æ‚ð‚¨’f‚肵‚Ä‚¨‚­�B
en-copyright=
kn-copyright=

en-aut-name=MatsubaraFumie
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en-aut-mei=Fumie
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ORCID=

en-aut-name=
en-aut-sei=
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kn-aut-name=Œõ‰„�²Žq
kn-aut-sei=Œõ‰„
kn-aut-mei=�²Žq
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ORCID=

en-aut-name=NagataTakuya
en-aut-sei=Nagata
en-aut-mei=Takuya
kn-aut-name=‰i“c‘ñ–ç
kn-aut-sei=‰i“c
kn-aut-mei=‘ñ–ç
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ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=’J�è�Ÿ˜N
kn-aut-sei=’J�è
kn-aut-mei=�Ÿ˜N
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=62
end-page=67
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Emphysematous changes of the lungs in asthmatics in the elderly. Differences between hyperinflation of the lungs by aging and pulmonary emphysema
kn-title=�‚—îŽÒšb‘§‚É‚¨‚¯‚é‹CŽî‰»ŒXŒü - ‰Á—î•Ï‰»‚Æ•a“I•Ï‰»�i”x‹CŽî�j‚Ì‘Šˆá“_
en-subtitle=
kn-subtitle=
en-abstract=?Pathophysiological changes by aging were examined in asthmatics in the elderly. 
1 . A level of serum IgE and frequency of positive RAST score
for allergens were in general low. However, the frequency of patients with family history of allergic diseases was considerably high, and in these patients with family history having allergic diseases the presence of IgE-mediated allergic reaction was frequently observed. 
2 . Bronchial hyperresponsiveness tended to decrease with
aging. 
3 . Ventilatory function and gas exchange (DLco) showed a decrease with aging, and the decrease in ventilatory function and DLco in older patients over age 70 was significantly
lower than the decrease in younger patients with asthma under age 49. 
4 . The volume of the lungs, evaluated by % residual volume (% RV) , tended to increase with aging. The low attenuation
area (LAA) of the lungs < -950 HU on HRCT, which represents hyperinflation in asthma, was also increased with aging. A significant correlation was found between % RV and % LAA of
the lungs <-950HU on HRCT in patients over age 70.
kn-abstract=�‚—îŽÒšb‘§‚Ì•a‘Ô“I“Á’¥‚ð—Õ�°“I‚ÉŠÏŽ@‚µ‚½�B‚»‚ÌŒ‹‰Ê‚͈ȉº‚Ì‚²‚Æ‚­‚Å‚ ‚Á‚½�B
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3�DŠ·‹C‹@”\�CƒKƒXŒðŠ·”\‚͉Á—î‚Æ‚Æ‚à‚ɒቺ‚µ�C“Á‚É70�ˈÈ�ã
‚Ì�Ç—á‚Å‚ÍŽá�”NŽÒšb‘§‚Æ”ä‚×—LˆÓ‚̒ቺ‚ªŒ©‚ç‚ꂽ�B�@
4�D”x—e�Ï‚Í�C‰Á—î‚Æ‚Æ‚à‚É‘�‘債�C70�ˈÈ�ã‚Ì�Ç—á‚Å‚Í—LˆÓ‚Ì‘�‘åŒXŒü‚ªŒ©‚ç‚ꂽ�B‚Ü‚½�C‚±‚Ì”x—e�Ï‚Ì‘�‘å‚Í�CHRCT�ã‚Ì�|950HUˆÈ‰º‚Ì”x% UIA‚Æ—LˆÓ‚Ì‘ŠŠÖ‚ªŒ©‚ç‚ê�C”x‚̉ߖc’£‚Ì�ó‘Ô‚ª‘¶�Ý‚·‚邱‚Æ‚ªŽ¦�´‚³‚ꂽ�B
en-copyright=
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ORCID=

en-aut-name=HosakiYasuhiro
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en-aut-name=AshidaKozo
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en-aut-name=IwagakiNaofumi
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aut-affil-num=4
ORCID=

en-aut-name=NagataTakuya
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aut-affil-num=5
ORCID=

en-aut-name=FujiiMakoto
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kn-aut-name=“¡ˆä�½
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en-aut-name=TakataShingo
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ORCID=

en-aut-name=YokoiTadashi
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ORCID=

en-aut-name=HamadaMasanori
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aut-affil-num=9
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=’J�è�Ÿ˜N
kn-aut-sei=’J�è
kn-aut-mei=�Ÿ˜N
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=?‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=10
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È
en-keyword=lgEŒn”½‰ž (IgE-mediated allergy)
kn-keyword=lgEŒn”½‰ž (IgE-mediated allergy)
en-keyword=‹C“¹‰ß•q�« (bronchial hyperresponsiveness)
kn-keyword=‹C“¹‰ß•q�« (bronchial hyperresponsiveness)
en-keyword=Š·‹C‹@”\ (ventilatory function)
kn-keyword=Š·‹C‹@”\ (ventilatory function)
en-keyword=ƒKƒXŒðŠ·”\ (gas exchange)
kn-keyword=ƒKƒXŒðŠ·”\ (gas exchange)
en-keyword=‹CŽî‰»ŒXŒü (emphysematous changes)
kn-keyword=‹CŽî‰»ŒXŒü (emphysematous changes)
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=48
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=QOL in LBP patients
kn-title=‰·�ò—Ö@‚ª�˜’É�ÇŠ³ŽÒ‚ÌQOL‚É‹y‚Ú‚·Œø‰Ê
en-subtitle=
kn-subtitle=
en-abstract=We have recently regarded the QOL as an important index in the treatment of disease. SF-36 is a measure of HRQOL made as an international standard. We investigated the QOL in LBP patients who underwent rehabiritation in our hospital using SF-36. We calculated PCS and MCS of SF-36. PCS went up from 41.1 to 43.6. MCS went up from 49.1 to 51.0. The spa therapy for LBP patients was effective.
kn-abstract=‹ß”NQOL‚ª�dŽ‹‚³‚ê‚é‚悤‚É‚È‚Á‚Ä‚«‚Ä‚¢‚é�BMOS short form 36 health survey�iˆÈ‰ºSF-36‚Æ—ª‚·�j‚Í�C�‘�Û“IƒŒƒxƒ‹‚Å‚ÌŠî�€‚Æ‚³‚ê‚é‚ׂ­ŠJ”­‚³‚ꂽ”ñŽ¾Š³“ÁˆÙ“IHRQOLŽÚ“x‚Å‚ ‚é�B�¡‰ñ�C‰ä�X‚Í“–‰@‚ŃŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‚ð‚¤‚¯‚Ä‚¢‚é�˜’É�ÇŠ³ŽÒ‚ð‘Î�ۂɉ·�ò—Ö@‚ÌQOL‚ɑ΂·‚éŒø‰Ê‚ðSF�|36‚ð—p‚¢‚Ä’²‚ׂ½�BSFL36‚Ì8�€–Ú‚ð‚»‚ê‚¼‚êŽZ�o‚µ�C‰·�ò—Ö@‘OŒã‚Å‚Ì”äŠr‚ð�s‚Á‚½�BPCS‚Í41.1‚©‚ç43.6‚Ö, MCS‚Í49.1‚©‚ç5l.0‚Ö�ã�¸‚µ‚½‚±‚Æ‚æ‚è�C�g‘Ì�E�¸�_–Ê‚Æ‚à‚ÉŒø‰Ê‚ª‚ ‚é‚Æ�l‚¦‚ç‚ꂽ�B
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kn-affil=?‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

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kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=10
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=11
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=12
en-affil=
kn-affil=‰ªŽR‘åŠw•�‘®•a‰@�®Œ`ŠO‰È
en-keyword=SF-36
kn-keyword=SF-36
en-keyword=�¶Šˆ‚ÌŽ¿ (QuaIity of Life)
kn-keyword=�¶Šˆ‚ÌŽ¿ (QuaIity of Life)
en-keyword=�˜’É�Ç (Low back Pain)
kn-keyword=�˜’É�Ç (Low back Pain)
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=42
end-page=47
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=IgEŒnƒAƒŒƒ‹ƒM�[”½‰ž‚̓Aƒgƒs�[Œ^‹CŠÇŽxšb‘§‚Ì”’ŒŒ‹…ƒ�ƒCƒRƒgƒŠƒGƒ“B4�iLTB4�j‚¨‚æ‚ÑC4�iLTC4�jŽY�¶‚ð‘£�i‚³‚¹�C‹i‰Œ‚Í‹C“¹‰ß•q�«‚ð˜´�i‚³‚¹‚é
kn-title=IgE-mediated allergy and cigarette smoking enhancethe generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leucocytes and bronchial hyperresponsiveness in patients with atopic asthma
en-subtitle=
kn-subtitle=
en-abstract=ƒnƒEƒXƒ_ƒXƒg‚ ‚é‚¢ƒJƒ“ƒWƒ_�RŒ´‚ɑ΂µ‚Ä“ÁˆÙ“IIgE�R‘Ì‚ª—z�«‚ðŽ¦‚·‹CŠÇŽxšb‘§69—á‚ð‘Î�Û‚É�CIgEŒn”½‰ž‚Æ‹i‰Œ‚Ì�C‹C“¹‰ß•q�«‚¨‚æ‚Ñ”’ŒŒ‹…‚ÌLTB4,LTC4ŽY�¶‚ɑ΂·‚é‰e‹¿‚ɂ‚¢‚ÄŒŸ“¢‚ð‰Á‚¦‚½�B�@
1�D‹C“¹‰ß•q�«‚Í�C”ñ‹i‰ŒŽÒ‚É”ä‚׋i‰ŒŽÒ‚Å‚æ‚è�‚“x‚Å‚ ‚邱‚Æ‚ª–¾‚ç‚©‚É‚³‚ꂽ�B�@
2�D”’ŒŒ‹…‚ÌLTC4�CLVC4ŽY�¶‚Í�CŒŒ�´IgE’l‚ª351’PˆÊ/mlˆÈ�ã‚Ì”ñ‹i‰Œ�Ç—á‚Å150’PˆÊˆÈ‰º‚¨‚æ‚Ñ151�|350’PˆÊ/ml‚Ì�Ç—á‚É”ä‚×—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ‚½�im4�Fp�ƒ0�D01�CLTC4�Fp�ƒ0�D05�j�B 
3�D’·ŠúŠÔ‚Ì•›�t”玿ƒzƒ‹ƒ‚ƒ““Š—^‚Í�CLTC4ŽY�¶‚ð—}�§‚µ‚½‚ª�C‹C“¹‰ß•q�«‚¨‚æ‚ÑLTB4ŽY�¶‚ɂ͉e‹¿‚µ‚È‚©‚Á‚½�B 
4�D�¡‰ñ‚̂悤‚ȃAƒgƒs�[Œ^šb‘§‚Å‚Í�C‹C“¹‰ß•q�«‚Æ”N—ß‚ÌŠÔ‚É‚Í—LˆÓ‚Ì‘ŠŠÖ‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½�BˆÈ�ã‚ÌŒ‹‰Ê‚æ‚è�CƒAƒgƒs�[šb‘§‚Å‚Í�CIgEŒn”½‰ž‚Í”’ŒŒ‹…‚ÌLTB4�CLTC4ŽY�¶‚ð‘£�i‚³‚¹�C‚Ü‚½‹i‰Œ‚Í‹C“¹‰ß•q�«‚ð‘£�i‚³‚¹‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½�B
kn-abstract=Influences of IgE-mediated allergy and cigarette smoking on pathophysiology, evaluated by bronchial hyperresponsiveness and the generation of LTB4 and LTC4, of asthma were examined in 69 patients with asthma sensitive to inhalant allergens such as house dust mite and Candida albicans.
1 . Bronchial byperresponsiveness was significantly higher in previous and current smokers of asthmatics than in never-smokers. 2 . The generation of leukotrienes 84 (LTB4) and C4 (LTC4) by leucocytes was significantly larger in patients with serum IgE over 350 IU/ml than in those with serum IgE less than 150 IU/ml (LTB4 : p<O. 01 , LTC4 : p<0.05) . 3 . Long term glucocorticoid regimen suppressed the generation of LTC4, but not bronchial hyperresponsiveness and LTB4 generation. 4 . Bronchial
hyperresponsiveness was not significantly correlated with patient age in thse patients with atopic asthma. The results demonstrate that IgE-mediated allergy significantly enhances the generation of LTB4 and LRC4 by leucocytes, and cigarette smoking significantly enhances bronchial hyperresponsiveness in patients with atopic asthma.
en-copyright=
kn-copyright=

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en-affil=
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en-affil=
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affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=10
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È
en-keyword=lgE-mediated allergy
kn-keyword=lgE-mediated allergy
en-keyword=bronchial hyperresponsiveness
kn-keyword=bronchial hyperresponsiveness
en-keyword=LTB4
kn-keyword=LTB4
en-keyword=LTC4
kn-keyword=LTC4
en-keyword=asthma
kn-keyword=asthma
en-keyword=cigarette smoking
kn-keyword=cigarette smoking
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=35
end-page=41
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
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en-title=”x‹CŽî‚Æšb‘§‚ÌHRCT�ã‚Ìlow attenuation are�iLAA�j‚Ì�«Ž¿‚Ì�·�B‹i‰Œ‚Æ‚ÌŠÖ˜A‚ðŠÜ‚ß‚Ä
kn-title=Difference in low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) between asthma and pulmonary emphysema in relation to cigarette smoking
en-subtitle=
kn-subtitle=
en-abstract=?‹CŠÇŽxšb‘§20—á�i10—á�F‹i‰Œ—á�C10—á”ñ‹i‰Œ—á�j‚¨‚æ‚Ñ”x‹CŽî10—á�i‘S—á‹i‰Œ—á�j‚ð‘Î�Û‚É�Chigh resolution computed tomography�iHRCT�j�ã‚Ì”x‚Ìlow attenuation area�iLAA�j‚Ì—Õ�°“IˆÓ‹`‚É
‚‚¢‚ÄŒŸ“¢‚ð‰Á‚¦‚½�B
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3�D% RV‚¨‚æ‚Ñ% DLco‚Í�C”x‹CŽî‚Æšb‘§�Ç—á‚Æ‚ÌŠÔ‚Å�C‚Ü‚½šb‘§�Ç—á‚Å‚Í�C‹i‰Œ—á‚Æ”ñ‹i‰Œ—á‚ÌŠÔ‚Å—LˆÓ‚Ì�·‚ªŒ©‚ç‚ꂽ�B
4�D% FVC�C% FEV1.0‚¨‚æ‚ÑFEV1.0%’l‚Í‚¢‚¸‚ê‚à�D”x‹CŽî‚Æšb‘§‚ÌŠÔ‚Å‚Í—LˆÓ‚Ì�·‚ªŒ©‚ç‚ꂽ‚ª�Cšb‘§‚Ì‹i‰Œ—á‚Æ”ñ‹i‰Œ—á‚ÌŠÔ‚É‚Í—LˆÓ‚Ì�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½�BˆÈ�ã‚ÌŒ‹‰Ê‚æ‚è�C”x‹CŽî‚Æšb‘§‚ÌŠÔ‚Å‚Í‘S‚Ẵpƒ‰ƒ��[ƒ^�[‚Å—LˆÓ�·‚ª�C‚Ü‚½šb‘§‚Ì‹i‰Œ—á‚Æ”ñ‹i‰Œ—á‚ÌŠÔ‚Å‚Í�CŒÄ‹CLAA/‹z‹CLAA”ä�C% RV�C% DLco‚Å—LˆÓ�·‚ªŒ©‚ç‚ê‚邱‚Æ‚ªŽ¦�´‚³‚ꂽ�B
kn-abstract=The low attenuation area (LAA) of the lungs on high resolution computed tomography (HRCT) was evaluated in 20 asthmatics (10 ex-smokers and 10 never-smokers) and 10 patients with pulmonary emphysema (all ex-smokers) by ventilatory function, lung volume, DLco, and a ratio of expiratory LAA/inspiratory LAA. 1 . The % LAA of the lungs on HRCT was significantly larger in patients with pulmonary emphysema(PE) than in those with asthma, but there was not significant difference in % LAA between ex-smokers and never-smokers of asthmatics. 
2. A ratio of expiratory Winspiratory LAA was significantly higher in patients with PE than in those with asthma , and the ratio was significantly higher in ex-smokers of asthmatics than in never-smokers (p<0.05). 
3 . The difference in % residual volume and % DLco was significant between asthma and PE , and between ex - smokers and never-smokers of asthmatics (% RV : p<0.05, DLco : p<0.05) . 4 . The difference in the values of % FVC, % FEV(1) .O, and FEV1.0% was significant between asthma and PE, but not significant between ex-smokers and never- smokers of asthmatics. The results suggest that the difference in a ratio of expiratory W inspiratory LAA, % RV and % DLco was
significant between ex - smokers and never - smokers of asthmatics , and cigarette smoking induces more irreversible changes of the lungs.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
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kn-affil=?‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=10
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È
en-keyword=low attenuation area
kn-keyword=low attenuation area
en-keyword=asthma
kn-keyword=asthma
en-keyword=pulmonary emphysema
kn-keyword=pulmonary emphysema
en-keyword=cigarette smoking
kn-keyword=cigarette smoking
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=26
end-page=34
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Characteristics of the elderly in high - resolution computed tomography lung densitometry
en-subtitle=
kn-subtitle=
en-abstract=?�‚—îŽÒ‚Ì•a‘Ô“I“Á’¥‚𖾂炩‚É‚·‚邽‚ß‚É�CŒ’�íŽÒ80—Ⴈ‚æ‚Ñ”ñ‹i‰Œšb‘§Š³ŽÒ80—á‚ð‘Î�Û‚Æ‚µ‚Ä�C•½‹Ï”xCT’l�iMLD�j‚È‚ç‚Ñ‚É�‚•ª‰ð”\CT�iHRCT�j‚É‚æ‚é�|950HUˆÈ‰º‚Ì”xlow attenuation area�iRA950�j‚ð•]‰¿‚µ�C”N—î‹y‚Ñ”x‹@”\‚Æ‚ÌŠÖ˜A‚ðŒŸ“¢‚µ‚½�B�@
1�DŒ’�íŽÒ�Cšb‘§Š³ŽÒ‚¢‚¸‚ê‚É‚¨‚¢‚Ä‚à”N—î‚Æ‚Æ‚à‚ÉMLD‚Í—LˆÓ‚ÉŒ¸�­‚µ�CRA(950)‚Í—LˆÓ‚É‘�‰Á‚µ‚½�BMLD‚Í�C60�|69�΂Æ70�ΈÈ�ã‚Ì”N
—î‘w‚É‚¨‚¢‚Ä�CŒ’�íŽÒ‚ɔ䂵‚Äšb‘§Š³ŽÒ‚Å—LˆÓ‚É’á’l‚ðŽ¦‚µ‚½�BRA(950)�B‚Í�C50�|59�Î�E60�|69�Î�E70�ΈÈ�ã‚Ì”N—î‘w‚É‚¨‚¢‚Ä�CŒ’�íŽÒ‚ɔ䂵‚Äšb‘§Š³ŽÒ‚Å—LˆÓ‚É�‚’l‚ðŽ¦‚µ‚½�B�@
2�Dšb‘§Š³ŽÒ‚É‚¨‚¢‚Ä�C1•b—Ê�i% FEV(1)�j‚¨‚æ‚Ñ1•b�iFEV(1)/ FVC�j‚Í�C49�Έȉº‚Ì”N—î‘w‚ɔ䂵‚Ä70�ΈÈ�ã‚Ì”N—î‘w‚Å—LˆÓ‚É’á’l‚ðŽ¦‚µ‚½�Bˆê•û�CŽc‹C—Ê�i% RV�j‚Í�C50�|59�΂Ȃç‚Ñ‚É49�Έȉº‚Ì”N—î‘w‚ɔ䂵‚Ä70�ΈÈ�ã‚Ì”N—î‘w‚Å—LˆÓ‚É�‚’l‚ðŽ¦‚µ‚½�B 
3�D50�|59�΂¨‚æ‚Ñ60�|69�΂̔N—î‘w‚Å‚Í�CRA(950)‚Í�CƒXƒeƒ�ƒCƒhˆË‘¶�«�d�Ǔ�«šb‘§�iSDIA�jŠ³ŽÒ‚É‚¨‚¢‚Ä”ñSDIAŠ³ŽÒ‚ɔ䂵‚Ä—LˆÓ‚É�‚’l‚ðŽ¦‚µ‚½�B‚µ‚©‚µ�C70�ΈÈ�ã‚Ì”N—î‘w‚Å‚Í—¼ŽÒ‚É—LˆÓ‚Ì�·‚Í”F‚ß‚ç‚ê‚È‚©‚Á‚½�B‚±‚ê‚ç‚ÌŒ‹‰Ê‚æ‚è�CHRCT�ã‚Ì”xlow attenuation area‚Í�‚—îŽÒ‚É‚¨‚¢‚Ä—LˆÓ‚É‘�‰Á‚·‚邱‚Æ�C‚³‚ç‚É�ú‘§Š³ŽÒ‚Ì•û‚ªŒ’�íŽÒ‚ɔ䂵‚Ä‚æ‚è�‚’l‚ðŽ¦‚·‚±‚Æ‚ªŽ¦�´‚³‚ꂽ�B
kn-abstract=To determine the characteristics of the elderly in high - resolution computed tomography (HRCT) lung densitometry, mean lung density (MLD) and relative area of the lungs showing attenuation values less than -950 HU (RA(950)) on HRCT were
evaluated in nonsmoking control subjects (n = 80) and patients with asthma (n = 80) in relation to their age and pulmonary function. MLD was significantly decreased, and
RAW was significantly increased with increasing age in both asthmatics and controls.
The MLD values were significantly lower in asthmatics compared with controls in subjects aged between 60 and 69 years and over age 70. RAgsov alues were significantly
higher in asthmatics compared with controls in subjects aged between 50 and 59 years, between 60 and 69, and over 70. % FEV(1) and FEV(1) / FVC were significantly decreased
in elderly asthmatic patients over 70 years of age compared with the values in those under 49. Percent residual volume (% RV) was significantly larger in patients over 70 years of age than in those between 50 and 59, and under 49 years. RAW was significantly larger in patients with steroid-dependent intractable asthma (SDIA) between 50 and 59 years of age, and between 60 and 69 compared with RA 950 in those without
SDIA. However, RAW did not differ significantly between SDIA and non-SDIA in patients over age 70. The results suggested that in % LAA of the lungs on HRCT was significantly increased in the elderly subjects with and without asthma, and it was significantly higher in the elderly asthmatics than the elderly controls.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=Œõ’앶—T
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kn-aut-mei=•¶—T
aut-affil-num=1
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
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ORCID=

en-aut-name=AshidaKozo
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en-aut-name=IwagakiNaofumi
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affil-num=2
en-affil=
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affil-num=3
en-affil=
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affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=10
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È
en-keyword=aging (‰Á—î)
kn-keyword=aging (‰Á—î)
en-keyword=high-resolution computed tomography (�‚•ª‰ð”\CT)
kn-keyword=high-resolution computed tomography (�‚•ª‰ð”\CT)
en-keyword=low attenuation area (’á‹zŽûˆæ)
kn-keyword=low attenuation area (’á‹zŽûˆæ)
en-keyword=mean lung density (•½‹ÏCT’l)
kn-keyword=mean lung density (•½‹ÏCT’l)
en-keyword=pulmonary function (”x‹@”\)
kn-keyword=pulmonary function (”x‹@”\)
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=18
end-page=25
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=’·ŠúŠÔ‚Ì‹i‰Œ‚Í�‚—îŽÒ‹CŠÇŽxšb‘§‚É‚¨‚¯‚é‹C“¹‰ß•q�«‚ÆŠÖ˜A‚µ‚½”’ŒŒ‹…LTB4ŽY�¶‚ð˜´�i‚³‚¹‚é
kn-title=Cigarette smoking enhances LTB4 generation by leucocytes associated with bronchial hyperresponsiveness in asthma in the elderly
en-subtitle=
kn-subtitle=
en-abstract=?‹CŠÇŽxšb‘§110—á‚ð‘Î�Û‚É�C’·ŠúŠÔ‚Ì‹i‰Œ‚Ì‹C“¹‰ß•q�«‚¨‚æ‚Ñ”’ŒŒ‹…‚̃�ƒCƒRƒgƒŠƒGƒ“B4ŽY�¶‚É‹y‚Ú‚·‰e‹¿‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½�B�@
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2�D”ñ‹i‰Œ—á‚É‚¨‚¢‚Ä‚Í�A‚»‚Ì‹C“¹‰ß•q�«‚Í49�ˈȉº‚Ì�Ç—á‚É‚¨‚¢‚Ä50�|59�Ë�C60�|69�Ë‚¨‚æ‚Ñ70�ˈÈ�ã‚Ì�Ç—á‚É”ä‚×�C—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ‚½�B‚µ‚©‚µ�C‹i‰Œ—á‚É‚¨‚¢‚Ä‚Í�C”N—ß‚É‚æ‚é‹C“¹‰ß•q�«‚Ì�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½�B�@
3�D60�ˈÈ�ã‚Ì�Ç—á‚Å‚Í�C‚»‚Ì‹C“¹‰ß•q�«‚Í”ñ‹i‰Œ—á‚É”ä‚×�C‹i‰Œ—á‚Å—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ‚½�B‚±‚̂悤‚È�Ç—á‚Å‚Í�CLTB4ŽY�¶”\‚à”ñ‹i‰Œ—á‚É”ä‚׋i‰Œ—á‚Å—LˆÓ‚̘´�i‚ªŒ©‚ç‚ꂽ�B�@
4�D”ñ‹i‰Œ—á‚Å‚Í�C‹C“¹‰ß•q�«‚ÆLTB4ŽY�¶‚Æ‚ÌŠÔ‚É—LˆÓ‚Ì‘ŠŠÖ‚ªŒ©
‚ç‚ꂽ�BˆÈ�ã‚ÌŒ‹‰Ê‚æ‚è�C60�ˈÈ�ã‚Ì�Ç—á‚Å‚Í‹i‰Œ‚ªLTB4ŽY�¶‚ð�Ž�i‚³‚¹�C‚»‚ÌŒ‹‰Ê‚Æ‚µ‚Ä‹C“¹‰ß•q�«‚ª˜´�i‚µ‚Ä‚­‚邱‚Æ‚ª�„‘ª‚³‚ꂽ�B
kn-abstract=Abstract : Influence of cigarette smoking on leukotriene 84 (LTB4) generation by leucocytes associated with bronchial hyperresponsiveness was examined in 110 patients with asthma. l. The frequency of positive RAST score for inhalant allergens and LTB4 generation by leucocytes were significantly larger in previous and current smokers than in nonsmokers. 2. In nonsmokers, bronchial hyperresponsiveness was significantly higher in asthmatics under the age of 49 years compared with that in patients between 50 and 59 years, between 60 and 69 years, and those over age 70 years. In
contrast, no significant differences were present between bronchial hyperresponsiveness and patient age in previous and current smokers. 3. In patients over age 60, bronchial hyperresponsiveness was significantly higher in previous and current smokers than in nonsmokers. In these patients, LTB4 generation was significantly more increased in previous and current smokers than in nonsmokers. 4. A significant
correlation was observed in asthmatics of nonsmokers between LTB4 generation and bronchial hyperresponsiveness . 5. LTC4 generation was significantly higher in previous and current smokers than in nonsmokers in patients under age 49 years.
These results show that in patients over age 60 years, cigarette smoking induces an increase in the generation of LTB4, leading to an increase in bronchial hyperresponsiveness
.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
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aut-affil-num=1
ORCID=

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aut-affil-num=3
ORCID=

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en-aut-sei=Iwagaki
en-aut-mei=Naofumi
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kn-aut-mei=�®Žj
aut-affil-num=4
ORCID=

en-aut-name=NagataTakuya
en-aut-sei=Nagata
en-aut-mei=Takuya
kn-aut-name=‰i“c‘ñ–ç
kn-aut-sei=‰i“c
kn-aut-mei=‘ñ–ç
aut-affil-num=5
ORCID=

en-aut-name=FujiiMakoto
en-aut-sei=Fujii
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kn-aut-name=“¡ˆä�½
kn-aut-sei=“¡ˆä
kn-aut-mei=�½
aut-affil-num=6
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en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=�‚“c�^Œá
kn-aut-sei=�‚“c
kn-aut-mei=�^Œá
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ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=‰¡ˆä�³
kn-aut-sei=‰¡ˆä
kn-aut-mei=�³
aut-affil-num=8
ORCID=

en-aut-name=HamadaMasanori
en-aut-sei=Hamada
en-aut-mei=Masanori
kn-aut-name=•l“c‘S‹I
kn-aut-sei=•l“c
kn-aut-mei=‘S‹I
aut-affil-num=9
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=’J�è�Ÿ˜N
kn-aut-sei=’J�è
kn-aut-mei=�Ÿ˜N
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=?‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È

affil-num=10
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”�EŽ•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ “à‰È
en-keyword=cigarette smoking
kn-keyword=cigarette smoking
en-keyword=asthma
kn-keyword=asthma
en-keyword=LTB4 generation
kn-keyword=LTB4 generation
en-keyword=LTC4 generation
kn-keyword=LTC4 generation
en-keyword=bronchial hyperresponsiveness
kn-keyword=bronchial hyperresponsiveness
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=11
end-page=17
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Clinical effects of long-term spa therapy on pulmonaryemphysema. Evaluation by pulmonary function and pathological changes of terminal airspace of the lung
en-subtitle=
kn-subtitle=
en-abstract=”x‹CŽî‚ɑ΂·‚é4”NˆÈ�ã‚ɂ킽‚鉷�ò—Ö@‚Ì—Õ�°Œø‰Ê‚ð,”x‹@”\‚Ì–Ê‚¨‚æ‚Ñ––�½”x—̈æ‚ÌŒ`‘ÔŠw“I•Ï‰»‚É‚æ‚è•]‰¿‚µ‚½¡ 
1.FVC,% FEV1.0,‚¨‚æ‚ÑFEV1.0%’l‚Í,‰·�ò—Ö@‚ðŽó‚¯‚½�Ç—á‚Ǝ󂯂Ȃ©‚Á‚½�Ç—á‚ÌŠÔ‚É—LˆÓ‚Ì�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡ 
2.ŠgŽU”\(DLco)‚Í,‰·�ò—Ö@‚ðŽó‚¯‚È‚©‚Á‚½�Ç—á‚Å‚Í,ŠÏŽ@�‰Šú‚Ì69.9%‚©‚ç4”NŒã‚É‚Í48.8%‚Æ—LˆÓ‚̒ቺ‚ðŽ¦‚µ‚½‚ª,‰·�ò—Ö@‚ð‘±
‚¯‚½�Ç—á‚Å‚Í,—LˆÓ‚̒ቺ‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡
3.% RV‚¨‚æ‚ÑHRCT�ã‚Ì-950HUˆÈ‰º‚Ì”x‚Ìlow attenuation area(LAA)‚Í,‚¢‚¸‚ê‚à‰·�ò—Ö@‚ðŽó‚¯‚È‚©‚Á‚½�Ç—á‚Å‚Í—LˆÓ‚Ì‘�‰ÁŒXŒü‚ðŽ¦‚µ‚½‚ª,‰·�ò—Ö@‚ðŽó‚¯‚½�Ç—á‚Å‚Í—LˆÓ‚Ì‘�‰ÁŒXŒü‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡ 4.Crnumber‚Í,‰·�ò—Ö@‚ðŽó‚¯‚È‚©‚Á‚½�Ç—á‚Å‚Í—LˆÓ‚̒ቺ‚ðŽ¦‚µ‚½‚ª,‰·�ò—Ö@‚𑱂¯‚½�Ç—á‚Å‚Í—LˆÓ‚̕ω»‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡‚±‚ê‚ç‚ÌŒ‹‰Ê‚æ‚è,”x‹CŽî‚ɑ΂·‚鉷�ò—Ö@‚𑱂¯‚邱‚Æ‚É‚æ‚è,% DLco‚â
% RV‚͉ü‘P‚·‚éŒXŒü‚ðŽ¦‚µ,“¯Žž‚É”x–E‚̉ߖc’¯‚Ì•”•ª(”j‰ó‚³‚ꂽ•”•ª‚Å‚Í‚È‚­)‚ª‰ü‘P‚³‚ê‚Ä‚¢‚­‰Â”\�«‚ªŽ¦�´‚³‚ê‚é¡
kn-abstract=Clinical effects of long-term spa therapy for 4 years were estimated in 8 patients of pulmonary emphysema (4 with spa therapy and 4 without spa therapy) by pulmonary function and morphological changes of peripheral airspaces of the lung on
high - resolution computed tomography (HRCT).
1 . The values of % FVC, % FEV1.0, and FEV 1.0% did not significantly change for 4year observation both in patients with spa therapy and those without spa therapy. 
2. The OLco value significantly decreased from 69.9% at the initial level to 48.8% after 4-year observation in patients without spa therapy (p<O.02). However, the DLco value did not significantly decrease in patients with spa therapy. 3. The values of % RV and % LAA of the lung showed a significant increase in patients without spa therapy (% RV: p<O.05, % LAA: p<O.Ol after 4-year observation compared with the initial levels), however, a change in % RV and % LAA was not significant in patients with spa therapy. 4. The CT number also significantly decreased in patients without spa
therapy, but not in those with spa therapy. The results suggest that spa therapy improves % DLco, % RV and morphological changes of peripheral airspaces, chiefly overinflation, of the lung in patients with pulmonary emphysema.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=Œõ‰„•¶—T
kn-aut-sei=Œõ‰„
kn-aut-mei=•¶—T
aut-affil-num=1
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=•Û�è‘×�O
kn-aut-sei=•Û�è
kn-aut-mei=‘×�O
aut-affil-num=2
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
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kn-aut-mei=�kŽO
aut-affil-num=3
ORCID=

en-aut-name=IwagakiNaofumi
en-aut-sei=Iwagaki
en-aut-mei=Naofumi
kn-aut-name=ŠâŠ_�®Žj
kn-aut-sei=ŠâŠ_
kn-aut-mei=�®Žj
aut-affil-num=4
ORCID=

en-aut-name=NagataTakuya
en-aut-sei=Nagata
en-aut-mei=Takuya
kn-aut-name=‰i“c‘ñ–ç
kn-aut-sei=‰i“c
kn-aut-mei=‘ñ–ç
aut-affil-num=5
ORCID=

en-aut-name=FujiiMakoto
en-aut-sei=Fujii
en-aut-mei=Makoto
kn-aut-name=“¡ˆä�½
kn-aut-sei=“¡ˆä
kn-aut-mei=�½
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ORCID=

en-aut-name=TakataShingo
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en-aut-mei=Shingo
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en-aut-sei=Yokoi
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en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
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ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=10
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”¥Ž•Šw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È
en-keyword=spa therapy (‰·�ò—Ö@)
kn-keyword=spa therapy (‰·�ò—Ö@)
en-keyword=pulmonary emphysema (,”x‹CŽî)
kn-keyword=pulmonary emphysema (,”x‹CŽî)
en-keyword=% RV
kn-keyword=% RV
en-keyword=% DLco
kn-keyword=% DLco
en-keyword=% low attenuation area of the lung
kn-keyword=% low attenuation area of the lung
END

start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=
article-no=
start-page=1
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Spa therapy for patients with respiratory disease. Analysis of 2295 patients admitted at Misasa Medical Center for last 22 years from 1982 to 2003
kn-title=ŒÄ‹zŠíŽ¾Š³‚̉·�ò—Ö@ -22”NŠÔ‚Ì“ü‰@�Ç—á2295—á‚ð‘Î�Û‚É-
en-subtitle=
kn-subtitle=
en-abstract=Analysis of 2295 patients with respiratory disease admitted at Misasa Medical Center for last 22 years from 1982 to 2003 was performed every five years. Of all patients with respiratory disease, 1910 (83.2%) patients had asthma and chronic obstructive pulmonary disease (COPD). 
1. Of 1910 patients showing obstructive ventilatory dysfunction, 1400 (73.3%) patients had asthma. The frequency of asthma in all patients with respiratory disease was 53. 8% for the first 5 years from 1982, 71. 7% for the second 5 years, 73.6% for the third 5 years, 53.9% for the fourth 5 years and 48.2% in the last two years. 
2. The frequency of steroid-dependent intractable asthma (SDIA) was from 23.6% to 41. 3% except the frequency (68.4%) for the first 5 years. The frequency of patients with SDIA
showed a tendency to decrease in recent years. The frequency of patients with pulmonary emphysema in those with COPD was very low 09.2% for the first 5 years) tended to increase
and 76.7% for the fourth 5 years and 87.4% in the last two years. The frequency of patients over age 60 was 30. 1% for the first 5 years, and showed a tendency to increase, and 67. 9% for the fourth 5 years and 82.7% in the last two years. 
3. The frequency of patients from distant areas outside Tottori prefecture was larger compared to the frequency inside Tottori prefecture. The number of patients from Okayama, Osaka, Hyogo, Tokyo, Ehime, Yamaguchi, and Kyoto was larger than the number from other distant areas.
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2.COPD�Ç—á‚Í,�‰Šú‚Ì5”NŠÔ(1982-1986”N)‚Å‚Í•½‹Ï5.2—á/”N‚©‚ç‘æ4Šú‚É‚Í44.6—á/”N‚Ö‚Æ8.7”{‚Ì,‚Ü‚½‘æ5Šú‚Å‚Í47.5—á/”N‚Ö‚Æ9.1”{‚Ì‘�‰Á‚ªŒ©‚ç‚ꂽ¡‚Ü‚½,‚»‚Ì‚È‚©‚Ì”x‹CŽî‚ª�è‚߂銄�‡‚Í�‰Šú‚Ì19.2%‚©‚ç‘æ4Šú‚Å‚Í76.7%,‘æ5Šú‚Å‚Í87.4%‚Æ–¾‚ç‚©‚È‘�‰ÁŒXŒü‚ðŽ¦‚µ‚½.�@
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en-title=On climatology in Misasa spa (twenty-forth report)
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en-abstract=Climatological data ofthe last 12 months (2001. 1. 1.- 2001. 12. 31) obtained by the climate autorecording system at the Misasa Medical Branch in Misasa Spa, Tottori-ken, Japan are presented.
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en-abstract=64�΂Ì�—�«¡1993”N2ŒŽ‚É�‚“x‚Ì‘O‹¹•”’É,�E�ê,ŒÄ‹z�¢“ï‚ðŽå‘i‚Æ‚µ‚Ä“ü‰@‚µ‚½¡“ü‰@Œã,‘O‹¹•”’É,šb–Â,ŒÄ‹z�¢“ï‚Í�™�X‚ÉŒy‰õŒXŒü‚Å‚ ‚Á‚½‚ª,–éŠÔ—¬—܂𔺂¤`‚ ‚­‚Ñ‚ª•p‰ñ‚É�oŒ»‚·‚é‚悤‚É‚È‚Á‚½¡`‚ ‚­‚Ñ'‚ª�oŒ»‚·‚鎞‚É‚Í,šb‘§�Ç�ó(šb–Â,ŒÄ‹z�¢“ï)‚Í”º‚í‚È‚¢‚ª,ƒs�[ƒNƒtƒ��[‚ɒቺ‚ð”F‚ß‚½¡`‚ ‚­‚Ñ'‚ɑ΂·‚鎡—ÂƂµ‚Ä‚Í,‹CŠÇŽxŠg’£�Ü,ƒ�ƒCƒRƒgƒŠƒGƒ“Žó—e‘ÌŒ‹�R�Ü‚Í’˜Œø,•›�t”玿ƒXƒeƒ�ƒCƒh�Ü‚Í’†“™“x
—LŒø‚Å‚ ‚Á‚½¡`‚ ‚­‚Ñ'‚ÍŽ¡—Âɔ½‰ž‚·‚éšb‘§‚Ì-�Ç�ó‚Å‚ ‚邱‚Æ‚ªŽ¦�´‚³‚ꂽ¡
kn-abstract=We present a case of a patient with asthma who developed yawning associated with anterior chest pain. She was admitted due to severe anterior chest pain, wheezing and dyspnea. Although the frequency of the symptoms decreased, she began to experience frequent episodes of yawning at night accompanied by tears. While she experienced yawning, although PEF (peak expiratory flow) decreased, no asthmatic
symptoms, such as wheezing or dyspnea were observed. The yawning was improved markedly by bronchodilators and a leukotriene receptor antagonist, and moderately improved by corticosteroids. We speculated that yawning is a clinical manifestation of asthma that responds to treatment.
en-copyright=
kn-copyright=

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en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È
en-keyword=yawning
kn-keyword=yawning
en-keyword=chest pain
kn-keyword=chest pain
en-keyword=nocturnal dyspnea
kn-keyword=nocturnal dyspnea
en-keyword=asthma
kn-keyword=asthma
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=93
end-page=101
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Influences of aging and cigarette smoking on pathophysiology in elderly patients with asthma (2)
kn-title=�‚—îŽÒ‹CŠÇŽxšb‘§‚Ì•a‘Ô‚É‚¨‚æ‚Ú‚·‰Á—‚æ‚Ñ‹i‰Œ‚̉e‹¿‚ɂ‚¢‚Ä(2)
en-subtitle=
kn-subtitle=
en-abstract=Influences of aging and cigarette smoking on the pathophysiology in elderly patients with asthma was examined in relation to characteristics of IgE-mediated allergic reaction, clinical pathophysiology, pulmonary function (ventilatory function and gas exchange ability; DLco), emphysematous change of the lungs, and therapy
for the disease. 
1. Participation of IgE-antibodies in the onset mechanisms of elderly asthma was more predominant in patients with a family history of allergic desease than those without the family history. 
2. Regarding asthma classified by clinical findings, the number of patients with hypersecretion or bronchiolar obstruction was larger than the number of those with simple
bronchoconstriction type. 
3. The values of parameters showing airflow (% FVC, FEV 1.0%)
and lung volume (% RV), as well as the value of DLco, were significantly lower in elderly asthmatics compared to younger patients. 
4. The low attenuation area (LAA) of the lungs <-950 HU on HRCT, showing emphysematous changes, as well as % RV, showed a tendency to increase as patient age become higher, however, these changes never shifted to emphysema. 
5. In the treatment of elderly asthma, clear-up of the airways by inhalation and / or swimming training in a hot spring pool, but not by medication, is very important.
kn-abstract=�‚—îŽÒ‹CŠÇŽxšb‘§‚ɂ‚¢‚Ä.IgE‚Émediate‚³‚ê‚éƒAƒŒƒ‹ƒM�[”½‰ž‚Ì“Á’¥�A—Õ�°•a‘Ô,”x‹@”\(Š·‹C‹@”\,ƒKƒXŒðŠ·),‹CŽî‰»ŒXŒü,Ž¡—Ã�ã‚Ì–â‘è“_‚È‚Ç‚ðŒŸ“¢‚µ‚½. 
1.�‚—îŽÒšb‘§‚É‚¨‚¯‚éIgE�R‘Ì‚ÌŠÖ—^‚Í—\‘zŠO‚É‘½‚­,‚µ‚©‚àƒAƒŒƒ‹ƒM�[‚̉Ƒ°—ð‚ð—L‚·‚é�Ç—á‚Å“Á‚É�‚“x‚Å‚ ‚Á‚½�B‚Ü‚½,‰Á—î‚Æ‚Æ‚à‚ÉŠ´�삳‚ê‚é�RŒ´‚ÌŽí—Þ‚ªˆÙ‚È‚Á‚Ä‚­‚邱‚Æ‚ªŽ¦�´‚³‚ꂽ�B
2.—Õ�°•a‘Ô‚Å‚Í,’P�ƒ�«‹CŠÇŽx�¹�kŒ^‚É”ä‚×,‹CŠÇŽx�¹�k+‰ß•ª”åŒ^‚â�׋CŠÇŽx•Â�ÇŒ^‚ª‘�‰Á‚·‚éŒXŒü‚ªŒ©‚ç‚ꂽ¡
3.”x‹@”\‚Å‚Í,airflow (% FVC,FEV1.0%)‚álung volume(% RV)‚ð‚ ‚ç‚í‚·ƒpƒ‰ƒ��[ƒ^�[‚Í,‚¢‚¸‚ê‚à70�ˈÈ�ã‚Ì�Ç—á‚ÅŽá�”NŽÒšb‘§‚É”ä‚×—LˆÓ‚ɒቺ‚µ‚Ä‚¢‚邱‚Æ‚ªŽ¦‚³‚ꂽ¡‚Ü‚½,transfer factor(% DLco)‚à70�ˈÈ�ã‚Ì�Ç—á‚Å‚Í—LˆÓ‚̒ቺŒXŒü‚ªŒ©‚ç‚ꂽ�B
4.HRCT�ã‚Ì1950HUˆÈ‰º‚Ì”x‚Ì% UIA‚Í,‰Á—î‚Æ‚Æ‚à‚É‘�‰Á‚·‚éŒXŒü‚ðŽ¦‚µ,% RV‚Ì‘�‰Á‚Æ“¯—l”x‚Ì‹CŽî‰»ŒXŒü‚ªŒ©‚ç‚ê‚邱‚Æ,‚µ‚©‚µ,‚±‚ÌŒ»�Û‚ª”x‹CŽî‚ւƈÚ�s‚·‚邱‚Æ‚Í‚È‚¢‚±‚Æ‚ªŽ¦‚³‚ꂽ.
5.Ž¡—Ã�ã‚Å‚Í,–ò•¨—Ö@‚æ‚è‚à‹C“¹‚Ì�ò‰»‚𑣂·‹z“ü‚â�…’†‰^“®(‰·�ò—Ö@‚È‚Ç)‚ª�d—v‚Å‚ ‚é‚Æ�l‚¦‚ç‚ꂽ¡
en-copyright=
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en-aut-sei=Yokoi
en-aut-mei=Tadashi
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affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=3
en-affil=
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affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[“à‰È

affil-num=10
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È
en-keyword=�‚—îŽÒšb‘§
kn-keyword=�‚—îŽÒšb‘§
en-keyword=IgE�R‘Ì
kn-keyword=IgE�R‘Ì
en-keyword=% RV
kn-keyword=% RV
en-keyword=% DLco
kn-keyword=% DLco
en-keyword=‹CŽî‰ÂŒXŒü
kn-keyword=‹CŽî‰ÂŒXŒü
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=72
end-page=74
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=QOL in OA patients
kn-title=‰·�ò—Ö@‚ª�œŠÖ�ß�ÇŠ³ŽÒ‚ÌQOL‚É‹y‚Ú‚·Œø‰Ê
en-subtitle=
kn-subtitle=
en-abstract=We have recently regarded the QOL as an important index in the treatment of disease. SF-36 is a measure of HRQOL made as an international standard. We investigated the QOL in OA
patients who underwent rehabiritation in our hospital using SF-36. We calculated PCS and MCS of SF-36. PCS went up from 36.4 to 37.
1. MCS went up from 53.0 to 55.4. The spa therapy for OA patients is effective.
kn-abstract=‹ß”NQOL‚ª�dŽ‹‚³‚ê‚é‚悤‚É‚È‚Á‚Ä‚«‚Ä‚¢‚é¡MOS short form 36 health survey(ˆÈ‰ºSF-36‚Æ—ª‚·)‚Í,�‘�Û“IƒŒƒxƒ‹‚Å‚ÌŠî�€‚Æ‚³‚ê‚é‚ׂ­ŠJ”­‚³‚ꂽ”ñŽ¾Š³“ÁˆÙ“IHRQOLŽÚ“x‚Å‚ ‚é.�¡‰ñ,‰ä�X‚Í“–‰@‚ŃŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‚ð‚¤‚¯‚Ä‚¢‚éOAŠ³ŽÒ‚ð‘Î�ۂɉ·�ò—Ö@‚ÌŒø‰Ê‚ðSF-36‚ð—p‚¢‚ÄQOL‚̕ω»‚𒲂ׂ½oSF-36‚Ì8�€–Ú‚ð‚»‚ê‚¼‚êŽZ�o‚µ,‰·�ò—Ö@‘OŒã‚Å‚ÌQOL‚Ì”äŠr‚ð�s‚Á‚½¡pCS‚Í36.4‚©‚ç37.1‚Ö,MCS‚Í53.0‚©‚ç55.4‚Ö�ã�¸‚µ‚½‚±‚Æ‚æ‚è,�g‘Ì¥Œ’“Œ–Ê‚Æ‚à‚ÉŒø‰Ê‚ª‚ ‚é‚Æ�l‚¦‚ç‚ꂽ¡
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ORCID=

affil-num=1
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affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠw•�‘®•a‰@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“•”

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start-page=64
end-page=71
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en-title=The level of plasma BNP continued remarkably high in the elderly presented with old myocardial infarction.
kn-title=BNP‚Ì’˜–¾‚È�‚’l‚ªŽ�‘±‚µ‚½�‚—îŽÒ’‹Œ�«�S‹Ø�[�ÇŠ³ŽÒ�@ (�‚—îŽÒ‚ÌBNP‚ɂ‚¢‚Ä‚Ì�lŽ@‚à‰Á‚¦‚Ä)
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en-abstract=The level of plasma BNP (Brain Natriuretic Peptide) increases with many factors, especially
among the elderly.
The heart increases the secretion of BNP to improves and maintains body fluid balance and hemodynamic state.
Furthennore, BNP works as the mechanism for self-protection in order to control remodeling the heart itself as well as to protect the heart from fibrotic progression and dyastolic dysfunction.
The heart acts not only as the cardiovascular pump but also as the endocrine organ which secretes diuretic peptide honnones.
kn-abstract=�S•s‘S‚ª”äŠr“I—Ç�D‚ɃRƒ“ƒgƒ��[ƒ‹‚³‚ê‚Ä‚¢‚é‚Ì‚É‚à‚©‚©‚í‚炸,�‚—î‚̒‹Œ�«�S‹Ø�[�nj㊳ŽÒ“™‚Å”]�«ƒiƒgƒŠƒEƒ€—˜”Aƒyƒvƒ`ƒh(BNP)‚̈Ù�í�‚’l‚ªŽ�‘±‚·‚é�ê�‡‚ª‚ ‚é.�¡‰ñ,‚Ü‚½’´�‚—î‚Ì�S•s‘SŠ³ŽÒ‚Å“¯�ŠŒ©‚ð”F‚ß‚½‚Ì‚Å,�lŽ@‚ðŠÜ‚ß‚Ä•ñ��‚·‚é.
93�Î�‚—î‚̒‹}�«�S‹Ø�[�ÇŠ³ŽÒ‚Å,BNP1600-1200‚Ì’˜–¾‚È�‚’l‚ªŽ�‘±‚µ‚½.Žå‚É�S�ë•”‚ƈꕔ‚Ì‘O‘¤•Ç‚̒‹Œ�«�S‹Ø�[�Ç�Ç‚Å‚ ‚Á‚½‚ª,—˜”A–ò“™‚É‚æ‚鎡—Âɂæ‚Á‚Ä�S•s‘S‚̓Rƒ“ƒgƒ��[ƒ‹‚Å‚«‚Ä‚¨‚è,‹~‹}“ü‰@Žž‚ð�œ‚¢‚Ä‚Í,ŸTŒŒ�«�S•s‘S‚Ì�ó‘Ô‚Å‚Í‚È‚©‚Á‚½.�SŠè’´‰¹
”gŒŸ�¸‚Å‚à�S“àˆ³‚Ì�ã�¸‚≺‘å�Ö¬‚ÌŠg’£‚à”F‚ß‚È‚©‚Á‚½.—˜”A–ò‚ð‘�—Ê‚·‚é‚Æ‚Þ‚µ‚ë’E�…‚É‚æ‚é�t‹@”\�áŠQ‚Ì‘�ˆ«‚ð”F‚ß‚Ä‚¢‚½.
“ü‰@’†‚É‹·�S’É‚ð”F‚߂邱‚Æ‚ª‚ ‚è,�S‹Øˆí’E�Œ‘f‚ÌŒy“x‚Ì�ã�¸‚ð”F‚ß‚½.BNP‚Ì’˜–¾‚È�‚’lŽ�‘±‚Í,’‹Œ�«�S‹Ø�[�ÇŒã‚Ì�S‘Ÿ‹@”\�áŠQ‚â�¶Žº”ì‘å,‘m–X•Ù•ÂŒz•s‘S“™‚É‚æ‚é–��«�S•s‘S¥�S•‰‰×‚Ì‚½‚ß‚Ì�S‹Ø‚Å‚ÌBNP�‡�¬¥•ª”匳�i‚Ì‘¼‚É,�V‚½‚È�¬�[�Ç(”ñŠÑ•Ç�«�S‹Ø�[�Ç)‚âŽ�‘±‚·‚é–³�ÇŒó�«‚Ì�S‹Ø‹•ŒŒ‚É‚æ‚é�S‹Ø‚Å‚ÌBNP�‡�¬¥•ª”嘴�i,�‚—î‚É‚æ‚éBNPƒNƒŠƒAƒ‰ƒ“ƒX‚̒ቺ‚Æ•ª”å‚ÌŽ�‘±“I˜´�i,–��«�t‹@”\�áŠQ‚É‚æ‚éBNPƒNƒŠƒAƒ‰ƒ“ƒX‚̒ቺ,�S‹Ø�áŠQŒã‚Ì�S‹Ø�Ä�\’z(ƒŠƒ‚ƒfƒŠƒ“ƒO)‚Ì–ó�ß‚Æ�S‹Ø‘@ˆÛ‰»—}�§‚ׂ̈É�‡�¬‚ªŒ³�i‚µ‚Ä‚¢‚é‚Æ�l‚¦‚ç‚ê‚é.�X‚É,‚¢‚í‚ä‚é˜V�l”x¥–��«ŒÄ‹z‹@”\’ቺ‚É‚æ‚é‰E�SŒn‚Ì•‰‰×‚É‚æ‚é�SŽº‚©‚ç‚Ì•ª”匳�i,ƒXƒeƒ�ƒCƒhƒzƒ‹ƒ‚ƒ““à•ž‚É‚æ‚é�zˆäƒRƒ‹ƒ`ƒRƒCƒh�ì—p,•nŒŒ,’á‰h—{�ó‘Ô“™‚Ì—l�X‚È—vˆö‚ª�d‚È‚Á‚Ä‚¢‚é‚à‚Ì‚Æ�l‚¦‚ç‚ꂽ.
�S‘Ÿ‚ÅBNP‚ÌŽY�¶¥•ª”傪˜´�i‚·‚é‚Ì‚Í,�S•s‘S‚É”º‚¤‘S�g‚̑̉t—ʃoƒ‰ƒ“ƒX‚⌌�s“®‘Ô“™‚̈«‰»‚ð‰ü‘P,’²�ß‚·‚邽‚ß‚¾‚¯‚Å‚Í‚È‚­,�S‘ŸŽ©�g‚̃Šƒ‚ƒfƒŠƒ“ƒO‚Ì’²�ߥ—}�§,�Ä�\’z‚Ì’²�d‚Ì‚½‚ß,‚³‚ç‚É‚Í�S‘Ÿ¥�S‹Ø‚Ì‘@ˆÛ‰»‚âŠg’£�áŠQ‚Ì‘�ˆ«‚ð—}�§‚·‚邽‚ß‚ÌŽ©ŒÈ–h‰q
‹@�\‚Æ‚µ‚Ä‚à‹@”\‚µ‚Ä‚¢‚é.�S‘Ÿ‚Í,’P‚É�zŠÂŒn‚̃|ƒ“ƒv‚Å‚Í‚È‚­,—˜”Aƒyƒvƒ`ƒhƒzƒ‹ƒ‚ƒ“‚𕪔傷‚é“à•ª”åŠíŠ¯‚Å‚à‚ ‚é.
ˆê”Ê“I‚ɉÁ—î‚É”º‚¢BNP‚Í�ã�¸‚µ‚Ä‚­‚é.“Á‚É70�ΈÈ�ã‚Ì�‚—îŽÒ‚Å‚ÍŒ°’˜‚É‚È‚é.�lŽ@‚Å‚Í‚»‚Ì“_‚ɂ‚¢‚Ä‚à�V‚½‚È•¶Œ£“I�lŽ@‚àŠÜ‚ß‚Ä•ñ��‚µ,�‚—îŽÒ‚ÌBNP‚Ì‘¨‚¦•û‚ÆŽ¡—Âɂ‚¢‚Ä‚à�q‚ׂé.
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en-keyword=bronchial asthma
kn-keyword=bronchial asthma
en-keyword=spa therapy
kn-keyword=spa therapy
en-keyword=perilla seed oil
kn-keyword=perilla seed oil
en-keyword=alpha -linolenic acid
kn-keyword=alpha -linolenic acid
en-keyword=Leukotriene C4
kn-keyword=Leukotriene C4
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=55
end-page=63
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
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en-title=‹CŠÇŽxšb‘§‚ɑ΂·‚鉷�ò—Ö@‚ƃ¿-ƒŠƒmƒŒƒ“Ž_‹­‰»�H‚ÌŒø‰Ê
kn-title=Effects of spa therapy combined with dietary supplementation with alpha -linolenic acids on bronchial asthma
en-subtitle=
kn-subtitle=
en-abstract=N-3ŒnŽ‰–bŽ_‚Íšb‘§‚É—LŒø‚Å‚ ‚邱‚Æ‚ª•ñ��‚³‚ê‚Ä‚¢‚é¡‚Ü‚½šb‘§‚ɑ΂·‚鉷�ò—Ö@‚Ì—LŒø�«‚à•ñ��‚³‚ê‚Ä‚¢‚é¡�¡‰ñ‰ä�X‚͉·�ò—Ö@‚Æn-3ŒnŽ‰–bŽ_‚𑽂­ŠÜ‚ÞƒGƒSƒ}–û�H‚Ìšb‘§‚ɑ΂·‚éŒø‰Ê‚ðŒŸ“¢‚µ‚½¡14–¼‚Ìšb‘§Š³ŽÒ‚ɉ·�ò—Ö@‹y‚у¿-ƒŠƒmƒŒƒ“Ž_(n-3Œn)‚𑽂­ŠÜ‚ÞƒGƒSƒ}–û�H‚Ì�ÛŽæ‚ð8�TŠÔ�s‚¢,‚»‚ÌŠÔ‚Ì”’ŒŒ‹…ƒ�ƒCƒRƒgƒŠƒGƒ“C
4(LTC4)‚ÌŽY�¶”\‚ƌċz‹@”\‚̕ω»‚ðŒŸ“¢‚µ‚½¡
‚»‚ÌŒ‹‰Ê”’ŒŒ‹…LTC4‚ÌŽY�¶”\‚ÍŽ¡—ÊJŽn2‰ßŒã‚æ‚è4,8‰ßŒã‚Æ—}�§‚³‚ꂽ(P<0.05)Oƒs�[ƒNƒtƒ��[’l(PEF)‚ÍŽ¡—Ã2,4,6,8�TŒã‚É—LˆÓ‚È‘�‰Á‚ª‚Ý‚ç‚ꂽ(P<0.05)¡‚Ü‚½ŒÄ‹z‹@”\[“w—Í”xŠˆ—Ê(FVC),1•b—Ê(FEV(1)),FEF(25),FEF(75),FEF(25-75)]‚ÍŽ¡—ÊJŽn4‰ß,8‰ßŒã‚É—LˆÓ‚ɉü‘P‚µ‚½(P<0.05)¡‚±‚ê‚ç‚ÌŒ‹‰Ê‚æ‚艷�ò—Ö@‚ƃGƒSƒ}–û�H‚Í”’ŒŒ‹…LTC4‚ÌŽY�¶”\‚ð—}�§‚·‚邱‚Æ‚É‚æ‚è,ŒÄ‹z‹@”\‚ð‰ü‘P‚³‚¹,‹CŠÇŽxšb‘§‚ÌŽ¡—ÂɗLŒø‚Å‚ ‚邱‚Æ‚ªŽ¦�´‚³‚ꂽ¡
kn-abstract=N-3 fatty acids are reportedly effective for asthma. In addition, spa therapy has been reported to be effective for patients with asthma. In the present study, the effects of spa therapy combined with perilla seed oil- rich diet (rich in n-3 fatty acid)were examined on asthma. A total of 14 asthmatic patients had a complex spa therapy and consumed a perilla seed oil- rich diet - rich in a -linolenic acid (alpha-LNA) for 8 weeks. Generation of leukotriene (LT) C4 by leucocytes, respiratory function were analyzed. The generation of LTC4 by leucocytes decreased significantly for 2, 4 and 8 weeks (P<O.05). Peak expiratory flow (PEF) values increased significantly for 2,4, 6 and 8 weeks (P<O.05). The values of ventilatory parameters [forced vital capacity (FVC) , forced expiratory volume in one second (FEV(1)) forced expiratory flow after
25% of expired FVC (FEF(25)), forced expiratory flow after 75% of expired FVC (FEF (75)) ? mean expiratory flow during the middle half of the FVC (FEF(25-75)) ] revealed a significant increase after 4 and 8 weeks of the modified diet (P<O.05). The results suggest that spa therapy combined with a perilla seed oil- rich diet are effective in the treatment of asthma in terms of its ability to suppress LTC4 generation by leucocytes, and in inducing an improvement of pulmonary function.
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kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=7
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affil-num=8
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kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=10
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=11
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰È
en-keyword=bronchial asthma
kn-keyword=bronchial asthma
en-keyword=spa therapy
kn-keyword=spa therapy
en-keyword=perilla seed oil
kn-keyword=perilla seed oil
en-keyword=alpha -linolenic acid
kn-keyword=alpha -linolenic acid
en-keyword=Leukotriene C4
kn-keyword=Leukotriene C4
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=49
end-page=54
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=�‚—îŽÒšb‘§‚ÌIgE‚Émediate‚³‚ê‚éƒAƒŒƒ‹ƒM�[”½‰ž‚É‚¨‚æ‚Û‚·‹i‰Œ‚̉e‹¿
kn-title=Effects of cigarette smoking on IgE-mediated allergy in elderly patients with asthma
en-subtitle=
kn-subtitle=
en-abstract=�‚—îŽÒšb‘§‚Ì•a‘Ԃɑ΂·‚é‹i‰Œ‚̉e‹¿‚ɂ‚¢‚Ä‚Í,‚È‚¨•s–¾‚È“_‚ª‘½‚¢¡–{Œ¤‹†‚Å‚Í,70�ΈÈ�ã‚Ì‹CŠÇŽxšb‘§40—á(‹i‰Œ—ð20”NˆÈ�ã‚Ì�Ç—á20—á,”ñ‹i‰Œ�Ç—á20—á)‚¨‚æ‚Ñ70�ΈÈ�ã‚Ì”x‹CŽî20—á(‘S—á‹i‰ŒŽÒ)‚ð‘Î�Û‚É,IgE-mediatedallergy(LTB4,LTC4‚ÌŽY�¶‚ðŠÜ‚Þ)‚ɑ΂·‚é‹i‰Œ‚̉e‹¿‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½¡ŒŒ�´IgE’l‚ª200IU/mlˆÈ
�ã‚ðŽ¦‚·�Ç—á‚Ì•p“x‚Í,šb‘§‚Ì‹i‰Œ—á‚Å”ñ‹i‰Œ—á‚â”x‹CŽî�Ç—á‚Æ”ä‚×—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ‚½¡‹z“ü�RŒ´‚ɑ΂·‚é“ÁˆÙ“IIgE�R‘Ì‚ª—z�«‚ðŽ¦‚·�Ç—á‚Ì•p“x‚Í,šb‘§‚Ì‹i‰Œ—á‚Å”ñ‹i‰Œ—á‚â”x‹CŽî‚É”ä‚×—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ‚½¡‚µ‚©‚µ,ŒŒ�´IgE‚ª200IU/mlˆÈ�ã‚Ì�Ç—á‚Ì•p“x‚¨‚æ‚ÑRAST—z�«—á‚Ì•p“x‚Í,šb‘§‚Ì”ñ‹i‰Œ—á‚Æ”x‹CŽî—á‚ÌŠÔ‚É‚Í—LˆÓ
‚Ì�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡LTB4‚ÌŽY�¶‚Í,šb‘§‚Ì‹i‰Œ—á‚Å,”ñ‹i‰Œ—á‚Æ”ä‚×—LˆÓ‚̘´�i‚ªŒ©‚ç‚ꂽ¡‚Ü‚½,”x‹CŽî—á‚Å‚Í,šb‘§‚Ì”ñ‹i‰Œ—á‚É”ä‚×,—LˆÓ‚É�‚‚¢ŽY�¶‚ªŒ©‚ç‚ꂽ¡‚µ‚©‚µ,LTC4‚ÌŽY�¶‚É‚Íšb‘§‚Ì‹i‰Œ—á,”ñ‹i‰Œ—á,”x‹CŽî—á‚ÌŠÔ‚É—LˆÓ‚Ì�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡
kn-abstract=The influence of cigarette smoking on the pathophysiology of asthma in the elderly remains controversial. In this study, the inluence of cigarette smoking on IgE - mediated
allergy including the generation of leukotrienes B4 (LTB4) and C4 (LTC4) was examined in forty asthmatics over the age of 70 years (20 ex-smokers and 20 never-smokers),
and 20 patients with pulmonary emphysema over age 70 (all ex - smokers). The frequency of patients with serum IgE more than 200 IU/ml was significantly larger in
smoking asthmatics than in non - smoking asthmatics. The incidence of patients with positive RAST score for inhalant allergens, was also significantly higher in patients
with a history of smoking than in those without a smoking history. There were no significant differences in the frequency of patients with positive RAST and those with serum IgE more than 200 IU/ml between non-smoking asthmatics and patients with pulmonary emphysema. The generation of leukotriene B4 (LTB4) by leukocytes was significantly more increased in ex-smokers than in never-smokers in the elderly asthmatics. The results suggest the possibility that cigarette smoking enhances IgE - mediated
allergy in elderly patients with asthma.
en-copyright=
kn-copyright=

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affil-num=2
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affil-num=3
en-affil=
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affil-num=4
en-affil=
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affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È
en-keyword=cigarette smoking
kn-keyword=cigarette smoking
en-keyword=IgE - mediated allergy
kn-keyword=IgE - mediated allergy
en-keyword=LTB4
kn-keyword=LTB4
en-keyword=LTC4 generation
kn-keyword=LTC4 generation
en-keyword=elderly asthmatics
kn-keyword=elderly asthmatics
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=44
end-page=48
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Airflow, the volume and transfer factor of lungs in elderly asthmatics with long-term cigarette smoking
en-subtitle=
kn-subtitle=
en-abstract=�‚—îŽÒ‹CŠÇŽxšb‘§40—á(20”NˆÈ�ã‚Ì‹i‰ŒŽÒ20—á,”ñ‹i‰ŒŽÒ20—á)‚¨‚æ‚Ñ”x‹CŽî(‘S�Ç—á‹i‰ŒŽÒ)20—á‚ð‘Î�Û‚É,’·ŠúŠÔ‹i‰Œ‚Ì”x‹@”\,airflow,lung volume ‚¨‚æ‚Ñlung transfer factor,‚É‹y‚Ú‚·‰e‹¿‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½¡‚Ü‚¸FVC’l‚Í,šb‘§‚Ì‹i‰Œ—á,”ñ‹i‰Œ—á,‚¨‚æ‚Ñ”x‹CŽî�Ç—á‚ÌŠÔ‚É—LˆÓ‚Ì�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡% FEV(1)‚¨‚æ‚ÑFEV(1)/FVC’l‚Í,‹i‰Œ—á,”ñ‹i‰Œ—á‚¢‚¸‚ê‚Ìšb‘§�Ç—á‚à”x‹CŽî‚Æ”ä
‚×—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ‚½‚ª,šb‘§‚Ì‹i‰Œ—á‚Æ”ñ‹i‰Œ—á‚ÌŠÔ‚É‚Í—LˆÓ�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡ˆê•û,% RV‚¨‚æ‚ÑDLco’l‚Í,šb‘§‚Ì”ñ‹i‰Œ—á‚É”ä‚×,‹i‰Œ—Ⴈ‚æ‚Ñ”x‹CŽî�Ç—á‚Å—LˆÓ‚É’á‚¢’l‚ðŽ¦‚µ‚½¡
‚±‚ê‚ç‚ÌŒ‹‰Ê‚Í,’·ŠúŠÔ‚Ì‹i‰Œ‚Í% FEV(1)‚âFEV(1)/FVC‚É‚Í‚ ‚Ü‚è‰e‹¿‚µ‚È‚¢‚±‚Æ, ‚µ‚©‚µ,% RV‚â% DLcO‚É‚Í‚©‚È‚è‰e‹¿‚·‚邱‚Æ‚ðŽ¦‚µ‚Ä‚¢‚é¡
kn-abstract=The influence of cigarette smoke on pulmonary function, airflow, lung volume, and transfer factor in patients with asthma was examined in 40 subjects over the age of 70 years (20 ever-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ex-smokers). The ventilatory parameters showing airflow limitation (% FEV(1) and FEV(1)%) were not significantly different between ever-smokers and never-smokers of elderly asthmatics. In contrast, % FEV(1) and FEV(1) % values were significantly lower in patients with pulmonary emphysema than in those with asthma with or without a history of smoking. The % RV value was significantly larger and % DLco value was significantly more decreased in ever-smokers compared with neversmokers of the elderly asthmatics. However, there were no significant differences in % RV and % DLco values between asthmatics with a history of smoking and patients
with pulmonary emphysema. The results show that cigarette smoke inflluences % RV and % DLco, but not % FEV(1) and FEV(1) %, suggesting airflow limitation of large and
moderate size airways.
en-copyright=
kn-copyright=

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aut-affil-num=3
ORCID=

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en-aut-sei=Tsugeno
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ORCID=

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ORCID=

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en-aut-sei=Takata
en-aut-mei=Shingo
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ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
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kn-aut-sei=’J�è
kn-aut-mei=�Ÿ˜N
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È
en-keyword=cigarette smoking
kn-keyword=cigarette smoking
en-keyword=FEV(1) %
kn-keyword=FEV(1) %
en-keyword=% RV
kn-keyword=% RV
en-keyword=% DLco
kn-keyword=% DLco
en-keyword=elderly asthmatics
kn-keyword=elderly asthmatics
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=39
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ƒŒ�[ƒU�[ƒhƒvƒ‰�[ŒŒ—¬Œv‚É‚æ‚é�‚—îŽÒ‚Ì––�½�zŠÂ‚Ì�”—Ê“I‰ð�Í
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=“œ”A•a‚â•Â�Ç�«“®–¬�d‰»�Ç(ASO)‚ÌŠ³ŽÒ‚É�‡•¹‚·‚é“�«’×ᇂâ‰óát‚Ì—\’m,—\–h‚ð–Ú“I‚Æ‚µ‚Ä�‚—îŽÒ‚Ì––�½�zŠÂ‚ÌŠÏŽ@‚ð�s‚Á‚½.
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ƒŒ�[ƒU�[ƒhƒvƒ‰�[ŒŒ—¬Œv‚Å“¾‚ç‚ꂽŒ‹‰Ê‚Í�¶‰E‘«æäŽn‹N•”5ƒJ�Š,Œv10ƒJ�Š‚Ì•½‹Ï’l‚Å•\‚µ‚½¡7—á‚ɂ‚¢‚Ä‚Í1”NŒã‚É�Ä‘ª’è‚ð�s‚Á‚½.14—á‚ɂ‚¢‚Ă̓vƒ�ƒXƒ^ƒOƒ‰ƒ“ƒfƒBƒ“�»�Ü(ƒxƒ‰ƒvƒ�ƒXƒg)‚ð“Š—^‚µ3ƒPŒŽŒã‚É�Ä‘ª’è‚ð�s‚Á‚½¡
1.Ž©‘RŒo‰ßŒQ‚Ì7—á(•½‹Ï”N—î73.0�Î)‚Í�‰‰ñ‘ª’莞‚ÌŒŒ—¬—Ê‚Í1.82�}0.98‚Å‚ ‚Á‚½¡2‰ñ–Ú‘ª’莞‚Í1.59�}0.40‚Å‚ ‚Á‚½¡ŒŒ—¬—ʂ̒ቺŒXŒü‚ð”F‚ß‚½‚ª—LˆÓ�·‚ð”F‚ß‚È‚©‚Á‚½¡
2.ˆê•û,ƒxƒ‰ƒvƒ�ƒXƒg“à•žŒQ‚Ì14—á(•½‹Ï”N—î70.6�Î)‚Í�‰‰ñ‘ª’莞‚ÌŒŒ—¬—Ê‚Í1.27�}0.35‚Å‚ ‚Á‚½¡2‰ñ–Ú‘ª’莞‚É‚Í1.62�}0.51‚Å‚ ‚Á‚½¡ŒŒ—¬—Ê‚Ì‘�‰Á‚ð”F‚ß‚½(P<0.0002)�B
3.—¼ŒQ‚ɂ‚¢‚Ä,3ƒ–ŒŽ“–‚½‚è‚̕ω»—¦‚Å”äŠr‚µ‚½‚Æ‚±‚뎩‘RŒo‰ßŒQ‚Í3ƒ–ŒŽ“–‚½‚è-1.7%‚̒ቺŒXŒü‚ðŽ¦‚µ‚½¡ˆê•û,ƒxƒ‰ƒvƒ�ƒXƒg“à•žŒQ‚Í+15.4%‚Ì‘�‰Á(p<0.02)‚ðŽ¦
‚µ‚½¡
4.ƒvƒ�ƒXƒ^ƒOƒ‰ƒ“ƒfƒBƒ“�»�Ü‚Ì“à•ž’†‚Å‚ ‚Á‚Ä‚à‰Á—î‚Æ‹¤‚É––�½�zŠÂŒŒ—¬I‚ª’ቺ‚·‚é�ǗႪ‚ ‚艷�ò—Ö@‚ðŠÜ‚ß‚½�WŠw“IŽ¡—Â̕K—v�«‚ªŽ¦�´‚³‚ꂽ¡
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en-keyword=‰Á—î (aging)
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kn-keyword=––�½�zŠÂ (Peripheral circulation)
en-keyword=“®–¬�d‰» (arteriosclerosis)
kn-keyword=“®–¬�d‰» (arteriosclerosis)
en-keyword=ƒŒ�[ƒU�[ƒhƒvƒ‰�[ŒŒ—¬Œv (Laser-Doppler blood flowmetry)
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start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=31
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
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kn-subject=
en-title=lgE‚Émediated‚³‚ê‚éƒAƒŒƒ‹ƒM”½‰ž�\ �A”x‹@”\�AHRCT�ã‚Ì”x‚Ìlow attenuatjonarea (LAA)�A‚¨‚æ‚ÑLTB4,LTC4ŽY�¶‚©‚猩‚½šb‘§‚Ì•a‘Ԃɑ΂·‚é‰Á—î‚̉e‹¿
kn-title=Effects of aging on the pathophysiology of asthma obsetved by IgE-mediated allergy, pulmoanry function, low attenuation area of the lungs on HRCT, and LTB4, LTC4 generation
en-subtitle=
kn-subtitle=
en-abstract=70�ΈÈ�ã‚Ì‹CŠÇŽxšb‘§20—á(•½‹Ï”N—ß74.3�Î)‚¨‚æ‚Ñ50�Έȉº‚Ì‹CŠÇŽxšb‘§20—á(32.5�Î)‚ð‘Î�Û‚É,IgE‚Émediate‚³‚ê‚éƒAƒŒƒ‹ƒM�[”½‰ž,”x‹@”\,HRCT�ã‚Ì”x‚ÌLAA‚Ì’ö“x,”’ŒŒ‹…‚É‚æ‚éLTB4,LTC4ŽY�¶‚Ȃǂɑ΂·‚é‰Á—î‚̉e‹¿‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½¡ŒŒ�´IgE’l‚ª200IU/mlˆÈ�ã‚Ì�Ç—á‚Ì•p“x‚¨‚æ‚Ñ‹z“ü�RŒ´‚ɑ΂·‚éRAST score‚ª—z�«‚ðŽ¦‚·�Ç—á‚Ì•p“x‚Í,‚¢‚¸‚ê‚àŽá�”NŽÒšb‘§‚Å�‚—îŽÒšb‘§‚Æ”ä‚×—LˆÓ‚É�‚‚¢ŒXŒü‚ðŽ¦‚µ‚½¡ % FVC,% FEV(1),FEV(1) % ’l‚Í‚¢‚¸‚ê‚àŽá�”NŽÒšb‘§‚Å�‚
—îŽÒšb‘§‚É”ä‚×—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ,‚Ü‚½,% RV‚Í�‚—îŽÒ‚Å—LˆÓ‚É�‚‚¢’l‚ªŽ¦‚³‚ꂽ¡ˆê•û,% DLco‚Í—¼ŽÒŠÔ‚É—LˆÓ‚Ì�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡
HRCT�ã‚Ì% LAA‚¨‚æ‚ÑLAA”ä(ŒÄ‹C/‹z‹C)‚¢‚¸‚ê‚à�‚—îŽÒšb‘§‚Å—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ,‰Á—î‚É‚æ‚è”x‚ÌLAA‚ª–¾‚ç‚©‚ɉe‹¿‚ðŽó‚¯‚邱‚Æ‚ª”»–¾‚µ‚½¡LTC4‚ÌŽY�¶‚ÍŽá�”NŽÒšb‘§‚Å‚â‚â�‚‚¢’l‚ªŽ¦‚³‚ꂽ‚ª,�‚—îŽÒ‚Æ‚ÌŠÔ‚É—LˆÓ�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡ˆê•û,LTB4ŽY�¶‚Í,Žá�”NŽÒšb‘§‚Å�‚—îŽÒšb‘§‚Æ”ä‚×—LˆÓ‚É�‚‚¢’l‚ªŽ¦‚³‚ꂽ¡‚±‚ê‚ç‚ÌŒ‹‰Ê‚Í,70�ΈÈ�ã‚Ì�‚—îŽÒšb‘§‚ł͉Á—î‚É‚æ‚é‰e‹¿‚ð�L”͈͂ɂ킽‚èŽó‚¯‚Ä‚¢‚é‰Â”\�«‚ª�‚‚¢‚±‚Æ‚ðŽ¦‚µ‚Ä‚¢‚é¡
kn-abstract=The influence of aging on the pathophysiology of asthma in the elderly was examined in 40 patients (20 younger asthmatics under the age of 50 years, mean age 32.5 years and 20 elderly asthmatics over the age of 70 years, mean age 74.3 years), relating to IgE - mediated allergy, pulmonary function, low attenuation area (LAA) of the lungs on HRCT, and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leukocytes. The frequency of patients with serum IgE of more than 200 IU/ml, and the incidence of those with a positive RAST score for inhalant allergens were significantly higher in younger patients than in elderly subjects. The values of % FVC, % FEV1 and FEV 1% were significantly larger in younger patients compared with elderly subjects. The % RV was significantly larger in elderly patients than in younger patients,
however, the difference in % DLco was not significant between the two age groups.
The LAA of the lungs on HRCT and the ratio of expiratory LAA (exp LAA) to inspiratory LAA (ins LAA) were also significantly larger in elderly asthmatics than in
younger subjects. The generation of LTB4 and LTC4 was larger in younger patients than in elderly subjects, and LTB4 generation was significantly larger in younger subjects
compared with elderly subjects. These results suggest that changes in IgE-mediated allergy, airflow and lung volume accompanied with hyperinflation are often observed
in elderly asthmatics.
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affil-num=5
en-affil=
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affil-num=6
en-affil=
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affil-num=7
en-affil=
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en-keyword=IgE-mediated allergy
kn-keyword=IgE-mediated allergy
en-keyword=pulmonary function
kn-keyword=pulmonary function
en-keyword=elderly asthmatics
kn-keyword=elderly asthmatics
en-keyword=HRCT
kn-keyword=HRCT
en-keyword=% RV
kn-keyword=% RV
END

start-ver=1.4
cd-journal=joma
no-vol=73
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no-issue=
article-no=
start-page=25
end-page=30
dt-received=
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dt-accepted=
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en-title=�‚—îŽÒšb‘§‚É‚¨‚¯‚é‹i‰Œ‚É‚æ‚é‹C“¹‰ß•q�«‚̘´�i‚ɂ‚¢‚Ä
kn-title=An increase in bronchial hyperresponsiveness by cigarette smoking in elderly patients with asthma
en-subtitle=
kn-subtitle=
en-abstract=�‚—îŽÒšb‘§‚Ì•a‘Ô‚É‚¨‚æ‚Û‚·‹i‰Œ‚̉e‹¿‚ɂ‚¢‚Ä‚Í‚È‚¨•s–¾‚È“_‚ª‘½‚¢¡–{˜_•¶‚Å‚Í,IgE‚Émediate‚³‚ê‚éƒAƒŒƒ‹ƒM�[”½‰ž,‹C“¹‰ß•q�«,ƒ�ƒCƒRƒgƒŠƒGƒ“B4 (LTB4),C4(LTC4)ŽY�¶‚É‹y‚Ú‚·‹i‰Œ‚̉e‹¿‚ɂ‚¢‚Ä,48—á(20”NˆÈ�ã‚Ì‹i‰Œ—ð‚Ì‚ ‚é�Ç—á25—á,”ñ‹i‰Œ—á23—á)‚Ì70�ΈÈ�ã‚Ì�‚—îŽÒšb‘§�Ç—á‚ð‘Î�Û‚ÉŒŸ“¢‚µ‚½¡
1.‹z“ü�RŒ´‚ɑ΂·‚é“ÁˆÙ“IIgE�R‘Ì‚Ì—z�«•p“x‚Í,‹i‰Œ—ð‚Ì‚ ‚é�Ç—á‚Å,”ñ‹i‰Œ—á‚Æ”ä‚×—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ‚½¡
2.ƒ�ƒTƒRƒŠƒ“‚ɑ΂·‚é‹C“¹‰ß•q�«‚ÌŒŸ“¢‚Å‚Í,•½‹ÏCmin‚Í,‹i‰Œ—á(949ƒÊg/ml)‚É‚¨‚¢‚Ä”ñ‹i‰Œ—á(1677ƒÊg/ml)‚É”ä‚×—LˆÓ‚É’á‚¢’l
‚ðŽ¦‚µ,‹i‰Œ—á‚Å‚æ‚è‹C“¹‚̉ߕq�«‚ª�‚‚¢‚±‚Æ‚ªŽ¦‚³‚ꂽ¡
3.LTB4‚ÌŽY�¶‚Í‹i‰Œ—á‚Å”ñ‹i‰Œ—á‚É”ä‚×—LˆÓ‚É�‚‚¢ŒXŒü‚ðŽ¦‚µ‚½‚ª,LTC4‚ÉŠÖ‚µ‚Ä‚Í—¼ŒQŠÔ‚É—LˆÓ‚Ì�·‚ÍŒ©‚ç‚ê‚È‚©‚Á‚½¡ˆÈ�ã‚Ì
Œ‹‰Ê‚æ‚è,’·ŠúŠÔ‚Ì‹i‰Œ‚Í,IgE‚Émediate‚³‚ê‚éƒAƒŒƒ‹ƒM�[‚âLTB4ŽY�¶‚̘´�i‚È‚Ç‚ð’Ê‚¶‚Ä‹C“¹‰ß•q�«‚ð˜´�i‚³‚¹‚é‰Â”\�«‚ªŽ¦�´‚³‚ꂽ¡
kn-abstract=Influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study was undertaken to clarify the influence of cigarette smoking on IgE-mediated allergy, bronchial hyperresponsiveness, and the generation of leukotrienes B4 (LTB4) and C4 (LTC4) by leukocytes in 48 elderly patients (25 patients with a history of smoking for more than 20 years and 23 never-smokers) with asthma over the age of 70 years. 1. The incidence of positive IgE antibodies for inhalant allergens was significantly higher in asthmatics with a history of smoking than in never-smokers of asthmatics. 2. In bronchial hyperresponsiveness for methacholine, the Cmin was significantly lower in ever-smokers than in never-smokers of elderly asthmatics. 3. The generation of LB4 was significantly increased in patients with a history of smoking compared with those without a smoking history. However, the difference in LTC4 generation was not significant between ever-smokers and never-smokers of asthmatics. These results suggest that cigarette smoking increases bronchial hyperresponsiceness through IgE-mediated allergy and LTB4 generation.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=Œõ‰„•¶—T
kn-aut-sei=Œõ‰„
kn-aut-mei=•¶—T
aut-affil-num=1
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=•Ûú±‘×�O
kn-aut-sei=•Ûú±
kn-aut-mei=‘×�O
aut-affil-num=2
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=ˆ°“c�kŽO
kn-aut-sei=ˆ°“c
kn-aut-mei=�kŽO
aut-affil-num=3
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=’Ñ–ì�_Žj
kn-aut-sei=’Ñ–ì
kn-aut-mei=�_Žj
aut-affil-num=4
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=�¼“c“T�”
kn-aut-sei=�¼“c
kn-aut-mei=“T�”
aut-affil-num=5
ORCID=

en-aut-name=NagataTakuya
en-aut-sei=Nagata
en-aut-mei=Takuya
kn-aut-name=‰i“c‘ñ–ç
kn-aut-sei=‰i“c
kn-aut-mei=‘ñ–ç
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ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=�‚“c�^Œá
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kn-aut-mei=�^Œá
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ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
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kn-aut-name=‰¡ˆä�³
kn-aut-sei=‰¡ˆä
kn-aut-mei=�³
aut-affil-num=8
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=’J�è�Ÿ˜N
kn-aut-sei=’J�è
kn-aut-mei=�Ÿ˜N
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È
en-keyword=cigarette smoking
kn-keyword=cigarette smoking
en-keyword=IgE - mediated allergy
kn-keyword=IgE - mediated allergy
en-keyword=elderly asthmatics
kn-keyword=elderly asthmatics
en-keyword=bronchial hyperresponsiveness
kn-keyword=bronchial hyperresponsiveness
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=19
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=�‚—îŽÒšb‘§‚É‚¨‚¯‚é HRCT �ã‚Ì”x‚Ì low attenuation area (LAA) ‚É‹y‚Ú‚·’·ŠúŠÔ‹i‰Œ‚̉e‹¿�D”x‹CŽî�Ç—á‚Æ‚Ì”äŠr�D
kn-title=Long-term cigarette smoking influences low attenuation area of the lungs on high-resolution CT in elderly patients with asthma, compared with pulmonary emphysema.
en-subtitle=
kn-subtitle=
en-abstract=70�ΈÈ�ã‚Ì‹CŠÇŽxšb‘§40—á(20—á‹i‰ŒŽÒ,20—á”ñ‹i‰ŒŽÒ)‚¨‚æ‚Ñ”x‹CŽî20—á‚ð‘Î�Û‚É,’·ŠúŠÔ‹i‰Œ‚ÌHRCT�ã‚Ì-950 HUˆÈ‰º‚Ì”x‚Ìlow atenuation area(LAA)‚É‹y‚Ú‚·‰e‹¿‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½�B
HRCT�ã‚Ì”x‚Ì% LAA‚Í,šb‘§‚Ì‹i‰Œ—á‚Å”ñ‹i‰Œ—á‚É”ä‚×—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ‚½¡‚Ü‚½,‚±‚Ì% LAA‚Í,”x‹CŽî�Ç—á‚Åšb‘§‚Ì‹i‰Œ—á‚É”ä‚ׂ³‚ç‚É�‚‚¢’l‚ðŽ¦‚µ‚½¡LAA”ä(ŒÄ‹CŽžLAA/‹z‹CŽžLAA)‚Í,�E‘§�Ç—á‚Å‚Í‹i‰Œ—á‚Å”ñ‹i‰Œ—á”ä‚×—LˆÓ‚É�‚‚¢’l‚ðŽ¦‚µ‚½‚ª,”x‹CŽî�Ç—á‚Å‚Í‚³‚ç‚É�‚‚¢’l‚ðŽ¦‚µ‚½¡LAA”ä0.5ˆÈ�ã‚ðŽ¦‚·�Ç—á‚Í,šb‘§‚Ì”ñ‹i‰Œ—á‚Å‚ÍŒ©‚ç‚ꂸ,‹i‰Œ—á‚Å20—á’†10—á,”x‹CŽî�Ç—á‚Å‚Í‘S—á‚ÉŒ©‚ç‚ꂽ¡‚»‚µ‚Ä,šb‘§‹i‰Œ—á‚ÅLAA”䂪0.5ˆÈ�ã‚ðŽ¦‚·�Ç—á‚Í,0.5ˆÈ‰º‚Ì�Ç—á‚É”ä‚×,% RV‚Í—LˆÓ‚É�‚‚­,‚Ü‚½% DLco‚Í—LˆÓ‚É’á‚¢’l‚ðŽ¦‚µ‚½¡‚µ‚©‚µ,% RV,% DLco’l‚¢‚¸‚ê‚àšb‘§‚ÌLAA”ä0.5ˆÈ�ã‚Ì�Ç—á‚Æ”x‹CŽî‚ÌŠÔ‚É‚Í—LˆÓ�·‚ÍŒ©‚ç‚ꂸ,šb‘§‚É‚¨‚¯‚é‹i‰Œ‚̉e‹¿‚Ì�‚‚¢‚±‚Æ‚ªŽ¦�´‚³‚ꂽ¡
kn-abstract=The influence of cigarette smoking on the pathophysiology in elderly patients with asthma. Forty asthmatics over the age of 70 years (20 ex-smokers and 20 never-smokers), and 20 patients with pulmonary emphysema over age 70 (all ever-smokers) were studied to determine the influence of cigarette smoke on the low attenuation area (LAA) <-950 HU (RA950) of the lungs on high resolution CT (HRCT) scans, and the ratio of expiratory LAA to inspiratory LAA of the lungs in relation to pulmonary function. The LAA value was significantly higher in patients with pulmonary emphysema compared with ever-smokers of asthmatics. The LAA ratio was significantly higher in ever-smokers than in never-smokers of asthmatics, and the ratio was less than 0.5 in all never-smokers, and the ratio was more than 0.5 in 10 of 20 ever-smokers of asthmatics and in all patients with pulmonary emphysema. The % RV (residual volume) was significaltly larger and % DLco (diffusing capacity for carbon monoxide) was significantly lower in subjects with the ratio more than 0.5 than in those with the ratio less than 0.5. These results suggest that cigarette smoke influences LAA of the lungs in relation to % RV value and % DLco value.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=Œõ‰„•¶—T
kn-aut-sei=Œõ‰„
kn-aut-mei=•¶—T
aut-affil-num=1
ORCID=

en-aut-name=HosakiYasuhiro
en-aut-sei=Hosaki
en-aut-mei=Yasuhiro
kn-aut-name=•Ûú±‘×�O
kn-aut-sei=•Ûú±
kn-aut-mei=‘×�O
aut-affil-num=2
ORCID=

en-aut-name=AshidaKozo
en-aut-sei=Ashida
en-aut-mei=Kozo
kn-aut-name=ˆ°“c�kŽO
kn-aut-sei=ˆ°“c
kn-aut-mei=�kŽO
aut-affil-num=3
ORCID=

en-aut-name=TsugenoHirofumi
en-aut-sei=Tsugeno
en-aut-mei=Hirofumi
kn-aut-name=’Ñ–ì�_Žj
kn-aut-sei=’Ñ–ì
kn-aut-mei=�_Žj
aut-affil-num=4
ORCID=

en-aut-name=NishidaNorikazu
en-aut-sei=Nishida
en-aut-mei=Norikazu
kn-aut-name=�¼“c“T�”
kn-aut-sei=�¼“c
kn-aut-mei=“T�”
aut-affil-num=5
ORCID=

en-aut-name=NagataTakuya
en-aut-sei=Nagata
en-aut-mei=Takuya
kn-aut-name=‰i“c‘ñ–ç
kn-aut-sei=‰i“c
kn-aut-mei=‘ñ–ç
aut-affil-num=6
ORCID=

en-aut-name=TakataShingo
en-aut-sei=Takata
en-aut-mei=Shingo
kn-aut-name=�‚“c�^Œá
kn-aut-sei=�‚“c
kn-aut-mei=�^Œá
aut-affil-num=7
ORCID=

en-aut-name=YokoiTadashi
en-aut-sei=Yokoi
en-aut-mei=Tadashi
kn-aut-name=‰¡ˆä�³
kn-aut-sei=‰¡ˆä
kn-aut-mei=�³
aut-affil-num=8
ORCID=

en-aut-name=TanizakiYoshiro
en-aut-sei=Tanizaki
en-aut-mei=Yoshiro
kn-aut-name=’J�è�Ÿ˜N
kn-aut-sei=’J�è
kn-aut-mei=�Ÿ˜N
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=8
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@ƒŠƒnƒrƒŠƒe�[ƒVƒ‡ƒ“‰È

affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•�‘®•a‰@ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È
en-keyword=cigarette smoking
kn-keyword=cigarette smoking
en-keyword=high resolution CT
kn-keyword=high resolution CT
en-keyword=% RV
kn-keyword=% RV
en-keyword=% DLco
kn-keyword=% DLco
en-keyword=elderly asthmatics
kn-keyword=elderly asthmatics
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=10
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=‹CŠÇŽxšb‘§‚Ì low attenuation are (LAA) ‚ɑ΂·‚é’·Šú‹i‰Œ‚̉e‹¿-4”NŠÔ‚ÌŒo‰ßŠÏŽ@-
kn-title=Influence of long-term cigarette smoking on changes of lung density by high-resolution computed tomography in asthmatics--4 years follow-up study
en-subtitle=
kn-subtitle=
en-abstract=‹CŠÇŽxšb‘§Š³ŽÒ‚Ì”x�‚•ª‰ð”\CT�ŠŒ©‚ɑ΂·‚é’·Šú‹i‰Œ‚̉e‹¿‚ðŒŸ“¢‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½¡”ñ‹i‰Œšb‘§Š³ŽÒ8–¼,‹i‰Œ—ð‚ð—L‚·‚éšb‘§Š³ŽÒ6–¼‚ð‘Î�Û‚Æ‚µ‚Ä,”x‹@”\,”x•½‹ÏCT’l(MLD),-950HUˆÈ‰º‚Ìlow attenuation area(RA(950))‚ɂ‚¢‚Ä4”NŠÔ‚ÌŒo‰ßŠÏŽ@‚ð�s‚Á‚½¡
4”NŠÔ‚ÌŠÏŽ@’†,”ñ‹i‰Œšb‘§Š³ŽÒ‚Å‚Í“w—Í”xŠˆ—Ê,1•b—ʂ̒ቺ‚ð”F‚ß‚½¡‹i‰Œ—ð‚ð—L‚·‚éšb‘§Š³ŽÒ‚Å‚Í“w—Í”xŠˆ—Ê,1•b—Ê,1•b—¦,”xŠgŽU”\
‚̒ቺ‚¨‚æ‚ÑŽc‹C—¦‚Ì‘�‰Á‚ð”F‚ß‚½¡‹i‰Œ—ð‚ð—L‚·‚éšb‘§Š³ŽÒ‚Å‚Í‹z‹C‚É‚¨‚¢‚Ä,�ã”x–ìMLD‚Ì—LˆÓ‚̒ቺ,RA(950)‚Ì—LˆÓ‚Ì�ã�¸‚ð”F‚ß‚½‚ª,”ñ‹i‰Œšb‘§Š³ŽÒ‚Å‚Í—LˆÓ‚̕ω»‚Í”F‚ß‚È‚©‚Á‚½¡’†”xRA(950)‚Í‹i‰Œ—ð‚ð—L‚·‚éšb‘§Š³ŽÒ,”ñ‹i‰Œšb‘§Š³ŽÒ‚Æ‚à‚É—LˆÓ‚Ì�ã�¸‚ð”F‚ß‚½¡‚Ü‚½,ŒÄ‹C‚É‚¨‚¢‚Ä,‹i‰Œ—ð‚ð—L‚·‚éšb‘§Š³ŽÒ‚ÅMLD‚Ì—LˆÓ‚̒ቺ,RA(950)‚Ì—LˆÓ‚Ì�ã�¸‚ð”F‚ß‚½‚ª,”ñ‹i‰Œšb‘§Š³ŽÒ‚Å‚Í—LˆÓ‚̕ω»‚Í”F‚ß‚È‚©‚Á‚½¡šb‘§Š³ŽÒ‚É‚¨‚¢‚Ä,‰Á—î‚ÍŽå‚É’†”x–ì‚Ìlow atenuation area,‹i‰Œ‚Í�ã”x–ì‚Ìlow atenuation area‚ɉe‹¿‚ð‹y‚Ú‚·‚±‚Æ‚ªŽ¦�´‚³‚ꂽ¡
kn-abstract=Background-The influence of cigarette smoking on the pathogenesis of asthma in the elderly remains controversial. This study attempts to estimate longitudinal changes in HRCT (high resolution computed tomography) parameters and pulmonary function parameters obtained for ex-smokers and never-smokers in asthmatics during 4-yr follow-up period. Methods-Fourteen asthmatics (6 ex-smokers and 8 never-smokers) were studied to determine the influence of aging and cigarette smoking on pulmonary function, and mean lung density (MLD) and the relative area of the lung showing attenuation values less than -950 HU (RA950) on HRCT scans. Results-The values of FVC and FEV1, were significantly more decreased in asthmatics without a smoking history during 4-yr follow-up period. The values of FVC, FEV1, FEV1/FVC and DLco/VA were significantly decreased and RV/TLC were significantly increased in asthmatics with a smoking history over 4 years, and annual decline in FEV1 ex-smokers was larger than that in never-smokers. In the upper lung field, inspiratory MLD was observed to shift in a negative direction and inspiratory RA950 was found to increase during 4-yr observation period in ex-smokers, but not in never-smokers. In the middle lung field, inspiratory RA950 was significantly enhanced in both two groups. Although expiratory MLD, expiratory RA950 and exp RA950/ins RA950 were observed to change significantly during the observation period in ex-smokers, no changes were observed in never-smokers. Conclusion-These results suggest that aging augments airspace enlargement predominantly in the middle lung field, while long term cigarette smoking further worsens emphysematous alterations in the upper lung field.
en-copyright=
kn-copyright=

en-aut-name=MitsunobuFumihiro
en-aut-sei=Mitsunobu
en-aut-mei=Fumihiro
kn-aut-name=Œõ‰„•¶—T
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kn-affil=‰ªŽR‘åŠwˆãŠw•”ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È�C•úŽË�üŽº

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kn-affil=‰ªŽR‘åŠwˆãŠw•”ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È�C•úŽË�üŽº

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en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”ŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È�C•úŽË�üŽº

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kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰È

affil-num=12
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰È
en-keyword=lung density
kn-keyword=lung density
en-keyword=high resolution computed tomography
kn-keyword=high resolution computed tomography
en-keyword=asthma
kn-keyword=asthma
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=
article-no=
start-page=1
end-page=9
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030201
dt-online=
en-article=
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en-title=Spa therapy for patients with respiratory disease. Analysis of 2129 patients admitted at Misasa Medical Center for last 21 years from 1982 to 2002
kn-title=ŒÄ‹zŠíŽ¾Š³‚̉·�ò—Ö@-21”NŠÔ‚Ì“ü‰@�Ç—á2129—á‚ð‘Î�Û‚É-
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en-abstract=Analysis of 2129 patients with respiratory disease admitted at Misasa Medical Center for last 21 years from 1982 to 2002 was performed every five years. Of all patients with respiratory disease, 1778 (83.5%) patients had asthma and
chronic obstructive pulmonary disease (COPD).
1. Of 1778 patients showing obstructive ventilatory
dysfunction, 1311 (73. 7%) patients had asthma. The frequency of asthma in all patients with respiratory disease was 53.8% for the first 5 years from 1982, 71. 7% for the second 5 years, 73.6% for the third 5 years, 53.9% for the last 5 years and 43.6% in 2002. 2. The frequency of
steroid -dependent intractable asthma (SDIA) was
from 25.9% to 41. 3% except the frequency (68.4%) for the first 5 years. The frequency of patients with SDIA showed a tendency to decrease in recent years. The frequency of patients with pulmonary emphysema in those with COPD
was very low 09.2% for the first 5 years) tended to increase and 76. 7% for the last 5 years and 88.5% in 2002. The frequency of patients over age 60 was 30. 1% for the first 5 years, and showed a tendency to increase, and
68.0% for the last 5 years and 85.4% in 2002.
3. The frequency of patients from distant areas outside Tottori prefecture was larger compared to the frequency inside Tottori prefecture. The number of patients from Okayama, Osaka, Hyogo, Tokyo, Ehime, Yamaguchi, and Kyoto
was larger than the number from other distant areas.
kn-abstract=1982”N‚©‚ç2002”N‚Ü‚Å‚Ì21”NŠÔ‚Ì“–ˆã—ÃZƒ“ƒ^�[‚Å“ü‰@‰Á—µ‚½2129—á‚ð‘Î�Û‚É5”NŠÔ–ˆ‚É‚»‚Ì”NŽŸ�„ˆÚ‚ðŒŸ“¢‚µ‚½�D2129—á‚Ì‚¤‚¿‚킯‚Í�C‹CŠÇŽxšb‘§1311—á�i61.5�“�j�CCOPD467—á�i21.9�“�j�C‚»‚Ì‘¼351—á‚Å‚ ‚Á‚½�D1. ‹CŠÇŽxšb‘§‚Í�C‘æ1Šú�i1982-1986”N�j‚Ì5”NŠÔ‚Å‚Í�C•½‹Ï11.4—á/”N‚Å‚ ‚Á‚½‚ª‘æ4Šú�i1997-2001”N�j‚Å‚Í•½‹Ï93—á‚Æ�‰Šú‚Æ”ä‚×8.1”{‚Ì‘�‰Á‚ªŒ©‚ç‚ꂽ�D‚Ü‚½�C‚»‚Ì‚È‚©‚ÌSDIA �isteroid-dependent intractable asthma�j‚Ì•p“x‚Í�‰Šú‚Ì68.4�“‚©‚ç‘æ4Šú‚Å‚Í28.9�“‚ɂ܂Œቺ‚·‚éŒXŒü‚ðŽ¦‚µ‚½�D2. COPD�Ç—á‚Í�C�‰Šú‚Ì5”NŠÔ�i1982-1986”N�j‚Å‚Í•½‹Ï5.2—á/”N‚©‚ç‘æ4Šú‚É‚Í45.4—á‚Ö‚Æ8.7”{‚Ì‘�‰Á‚ªŒ©‚ç‚ꂽ�D‚Ü‚½�C‚»‚Ì‚È‚©‚Ì”x‹CŽî‚ª�è‚߂銄�‡‚¢‚Í�‰Šú‚Ì19.2�“‚©‚ç‘æ4Šú‚Å‚Í78.5�“‚Æ–¾‚ç‚©‚È‘�‰ÁŒXŒü‚ðŽ¦‚µ‚½�D‚È‚¨�C�ð”N“x‚Ì1”NŠÔ‚Å‚Í�C‘æ4Šú‚Ì5”NŠÔ�i1997-2001”N�j‚Æ‚Ù‚Ú“¯—l‚ÌŒXŒü‚ðŽ¦‚µ‚½‚ª�C‘S”Ê“I‚ÈŒXŒü‚Æ‚µ‚Ä‚Í‹CŠÇŽxšb‘§�ǗႪ‚â‚⌸�­‚µ�Cˆê•û”x‹CŽî�ǗႪ‘�‰Á‚·‚éŒXŒü‚ªŒ©‚ç‚ꂽ�D3. ‹CŠÇŽxšb‘§‚¨‚æ‚ÑCOPD�Ç—á‚Ì”N—î•ÊŒŸ“¢‚Å‚Í�C60�ΈÈ�ã‚Ì�Ç—á‚Ì•p“x‚Í‘æ1Šú‚Å‚Í30.1�“‚¾‚ ‚Á‚½‚ª�C‘æ4Šú‚Å‚Í68.0�“�C‚»‚µ‚Ä�ð”N“x‚Í85.4�“‚Æ�C”N�X‚»‚Ì•p“x‚Í�‚‚­‚È‚Á‚Ä‚¢‚­ŒXŒü‚ªŒ©‚ç‚ꂽ�D‚·‚È‚í‚¿�C�Å‹ß21”NŠÔ‚Ì”NŽŸ�„ˆÚ‚©‚ç‚Í�C‰·�ò—Ö@‚ð•K—v‚Æ‚·‚éŒÄ‹zŠíŽ¾Š³Š³ŽÒ‚ª‘�‰Á‚µ‚‚‚ ‚邱‚Æ�C‚»‚µ‚Ä‚»‚Ì”N—ß‚Í”N�X�‚‚­‚È‚éŒXŒü‚É‚ ‚邱‚Æ‚ªŽ¦‚³‚ꂽ�D
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en-aut-name=TanizakiYoshiro
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affil-num=1
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affil-num=2
en-affil=
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affil-num=3
en-affil=
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affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=7
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È

affil-num=8
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affil-num=9
en-affil=
kn-affil=‰ªŽR‘åŠwŽO’©ˆã—ÃZƒ“ƒ^�[�@“à‰È
en-keyword=šb‘§
kn-keyword=šb‘§
en-keyword=COPD
kn-keyword=COPD
en-keyword=‰·�ò—Ö@
kn-keyword=‰·�ò—Ö@
en-keyword=�‚—îŽÒ
kn-keyword=�‚—îŽÒ
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=5-6
article-no=
start-page=463
end-page=472
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on clinical course and prognosis of chronic pancreatitis Part 1. Chief complaint, pancreatogram, exocrine function and glucose tolerance at diagnosis, and their serial changes
kn-title=–��«äX‰Š‚ÌŒo‰ß‚Æ—\Œã‚ÉŠÖ‚·‚錤‹† ‘æ1•Ò �f’fŽž‚Ì�ó‘Ô‚ÆäXŠÇ‘œ�CäXŠO•ª”å‹@”\�C‘Ï“œ”\‚ÌŒoŽž“I•Ï‰»‚ɂ‚¢‚Ä
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the chief complaints, pancreatograms, pancreatic exocrine function and glucose tolerance at diagnosis and their serial changes in chronic pancreatitis (CP), 112 patients with alcoholic CP, nine with biliary CP and 49 with idiopathic CP were studied. The following conclusions were obrained. Seventy-seven patients with alcoholic CP, nine with biliary CP and 22 with idiopahtic CP had presented with recurrent abdominal pain for more than one year before the time of diagnosis. Chief complaints consisted of abdominal pain , diabetes mellitus and others. Proportion of patients with abdominal pain was significantly higher in alcoholic CP than in idiopathic CP. Elderly patients with CP presented with abdominal pain less frequently than non-elderly patients. These findings indicate that chronic pancreatitis should be considered when diagnosing and treating diabetics and the elderly. Patients with alcoholic CP were significantly younger than those with nonalcoholic CP at diagnosis. Sex distribution showed male predominance in alcoholic CP and female predominance in nonalcoholic CP. Calcification in the pancreas was detected more frequently in alcoholic CP than in nonalcoholic CP. The number of patients with CP increased in more recent years.
Alcoholic CP showed more severe damage of the pancreas than nonalcoholic CP at the time of diagnosis. No differences between alcoholic CP and nonalcoholic CP were found in the frequency of the progressive changes in pancreatograms. Deteriorative changes in pancreatic exocrine function were not related with etiological category, but improvement was observed frequently in nonalcoholic CP. The deterioration of glucose tolerance was not related with etiological category, drinking habit and pain relief.
en-copyright=
kn-copyright=

en-aut-name=MiyakeHirofumi
en-aut-sei=Miyake
en-aut-mei=Hirofumi
kn-aut-name=ŽO‘îŒ[•¶
kn-aut-sei=ŽO‘î
kn-aut-mei=Œ[•¶
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰ÈŠw‹³Žº
en-keyword=–��«äX‰Š
kn-keyword=–��«äX‰Š
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en-keyword=‘Ï“œ”\
kn-keyword=‘Ï“œ”\
en-keyword=ŒoŽž“I•Ï‰»
kn-keyword=ŒoŽž“I•Ï‰»
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=1
article-no=
start-page=115
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Difference in Professional Ability that Young Teachers Feel from Skilled Teachers through Lesson Study -Basic Investigation Toward Development of a System that Supports Young Teachers for Enhancement of Professional Ability-
kn-title=Žö‹ÆŒ¤‹†‚ð’Ê‚µ‚ÄŽáŽè‹³Žt‚ªŠ´‚¶‚é�n—û‹³Žt‚Æ‚Ì�·--ŽáŽè‹³Žt‚Ì�E”\�¬’·‚ðŽx‰‡‚·‚éƒVƒXƒeƒ€‚ÌŠJ”­‚ÉŒü‚¯‚Ä‚ÌŠî‘b’²�¸
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=‹³Žt‚Ì�E”\‚Ì�¬’·‚Í�¡‚à�Ì‚à•Ï‚í‚炸�‘‚Ì�d—v‚ȉۑè‚Ì1‚‚ƂȂÁ‚Ä‚¢‚é�B‚±‚ê‚Ü‚Å‹³Žt‚Ì�E”\�¬’·‚É�d—v‚È–ðŠ„‚ð‰Ê‚½‚µ‚Ä‚«‚½‚à‚Ì‚Ì1‚‚ªŽö‹ÆŒ¤‹†‚Å‚ ‚é‚ÆŒ¾‚¦‚邪�A‹ß”N‚Í‹³Žt‚Ì‘½–Z‚³‚È‚Ç‚Ì—�—R‚ÅŽÀŽ{‚³‚ê‚É‚­‚­‚È‚Á‚Ä‚¢‚é‚Ì‚ªŒ»�ó‚Å‚ ‚é�B‚±‚Ì‚±‚Æ‚©‚ç�A•MŽÒ‚ç‚Í‹óŠÔ“I�EŽžŠÔ“I�§–ñ‚ð•”•ª“I‚ɉð�Á‰Â”\‚ȃlƒbƒgƒ��[ƒN‚ðŠˆ—p‚µ‚½Webƒx�[ƒX‚ÌŽö‹ÆŒ¤‹†Žx‰‡�ueLESSER�vƒvƒ�ƒOƒ‰ƒ€‚ðŠJ”­�EŽÀŽ{‚µ‚½�B2005”N“x‚ÉŽÀŽ{‚µ‚½‚±‚̃vƒ�ƒOƒ‰ƒ€‚É‚Í4�l‚Ì‹³Žt‚ªŽQ‰Á‚µ‚½�B‚±‚Ì‚¤‚¿2�l‚Í‹³ŽtŒoŒ±15”NˆÈ�ã‚Ì�n—û‹³Žt‚Å‚ ‚è�Aƒvƒ�ƒOƒ‰ƒ€‚̃vƒ�ƒZƒX‚ÅŽö‹Æ�ÝŒv�AŽÀŽ{�AŽö‹Æ‚ɂ‚¢‚Ä‚Ì‹c˜_‚ð�s‚Á‚½�BŽc‚è‚Ì2�l‚Í‹³ŽtŒoŒ±10”N–¢–ž‚ÌŽáŽè‹³Žt‚Å�A2�l‚Ì�n—û‹³Žt‚É‚æ‚銈“®‚ðWeb�ã‚ÅŠÏŽ@‚µ‚½�B–{�e‚Å‚Í�A‚±‚ÌeLESSERƒvƒ�ƒOƒ‰ƒ€‚ð’Ê‚µ‚ÄŽáŽè‹³Žt‚ªŠ´‚¶‚½�n—û‹³Žt‚Æ‚Ì�E”\�·‚ɂ‚¢‚Ä’²�¸�E•ª�Í‚µ‚½Œ‹‰Ê‚ɂ‚¢‚Ä•ñ��‚µ�AŽáŽè‹³Žt‚Ì�E”\�¬’·‚ðŽx‰‡‚·‚éƒVƒXƒeƒ€ŠJ”­‚Ö‚ÌŽw�j‚ðŽ¦‚·�B
en-copyright=
kn-copyright=

en-aut-name=KasaiToshinobu
en-aut-sei=Kasai
en-aut-mei=Toshinobu
kn-aut-name=Š}ˆä�r�M
kn-aut-sei=Š}ˆä
kn-aut-mei=�r�M
aut-affil-num=1
ORCID=

en-aut-name=SuzukiMariko
en-aut-sei=Suzuki
en-aut-mei=Mariko
kn-aut-name=—é–Ø�^—�Žq
kn-aut-sei=—é–Ø
kn-aut-mei=�^—�Žq
aut-affil-num=2
ORCID=

en-aut-name=NagataTomoko
en-aut-sei=Nagata
en-aut-mei=Tomoko
kn-aut-name=‰i“c’qŽq
kn-aut-sei=‰i“c
kn-aut-mei=’qŽq
aut-affil-num=3
ORCID=

en-aut-name=NishimoriToshihisa
en-aut-sei=Nishimori
en-aut-mei=Toshihisa
kn-aut-name=�¼�X”NŽõ
kn-aut-sei=�¼�X
kn-aut-mei=”NŽõ
aut-affil-num=4
ORCID=

en-aut-name=MochizukiToshio
en-aut-sei=Mochizuki
en-aut-mei=Toshio
kn-aut-name=–]ŒŽ�r’j
kn-aut-sei=–]ŒŽ
kn-aut-mei=�r’j
aut-affil-num=5
ORCID=

en-aut-name=NakaharaJun
en-aut-sei=Nakahara
en-aut-mei=Jun
kn-aut-name=’†Œ´�~
kn-aut-sei=ՠΫ
kn-aut-mei=�~
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”

affil-num=2
en-affil=
kn-affil=Ž ‰ê‘åŠw

affil-num=3
en-affil=
kn-affil=•ºŒÉ‹³ˆç‘åŠw

affil-num=4
en-affil=
kn-affil=“Œ‹ž‘åŠw

affil-num=5
en-affil=
kn-affil=“Œ‹ž‘åŠw

affil-num=6
en-affil=
kn-affil=“Œ‹ž‘åŠw
en-keyword=Žö‹ÆŒ¤‹† (Lesson Study)
kn-keyword=Žö‹ÆŒ¤‹† (Lesson Study)
en-keyword=‹³Žt‚Ì�E”\ (Professional Ability)
kn-keyword=‹³Žt‚Ì�E”\ (Professional Ability)
en-keyword=Webƒx�[ƒXƒVƒXƒeƒ€ (Web-based System)
kn-keyword=Webƒx�[ƒXƒVƒXƒeƒ€ (Web-based System)
en-keyword=ŽáŽè‹³Žt (Young Teacher)
kn-keyword=ŽáŽè‹³Žt (Young Teacher)
en-keyword=�E”\�¬’·Žx‰‡ (Teacher Education)
kn-keyword=�E”\�¬’·Žx‰‡ (Teacher Education)
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=5-6
article-no=
start-page=589
end-page=600
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of human bone marrow stromal cells in the aged Part 1. Influence of aging on composition, growing dynamics and cytokine production in human bone marrow stromal cells
kn-title=�œ�‘ŠÔŽ¿�×–E‚̘V‰»‚ÉŠÖ‚·‚錤‹†�@‘æ1•Ò�@ƒqƒg�œ�‘ŠÔŽ¿�×–E‚Ì�×–E�\�¬”ä—¦�C‘��B“®‘Ô‹y‚Ñ‘¢ŒŒˆöŽqŽY�¶”\‚É‹y‚Ú‚·‰Á—î‚̉e‹¿
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Bone marrow stromal cells (BMSC) play essential roles in hemopoiesis. In the present study, bone marrow specimens obtained from 23 normal volunteers were cultured with a modified version of Dexter's long term bone marrow culture system to investigate the influences of aging on human BMSC. The composition of BMSC was analyzed by immunofluorescence. The percentage of monocyte/macrophages, adipocytes and T-cells were significantly increased in the aged. BMSC from the aged proliferated more rapidly than those from the young during the first week of culture in the growing dynamics study. Cytokine concentration in the conditioned medium was also measured in terms of BMSC function by radioimmunoasssay or enzyme-linked immunosorbent assay. The concentration of macrophage colony stimulating factor (M-CSF) on day 21 increased in the culture from the young, while interleukin-6(IL-6) concentration was higher on day 7 in the culture from the aged. These findings show no evidnece of BMSC defects in the aged. They show evidnece suggesting advanced function.
en-copyright=
kn-copyright=

en-aut-name=DeguchiSeigo
en-aut-sei=Deguchi
en-aut-mei=Seigo
kn-aut-name=�oŒû�ÃŒá
kn-aut-sei=�oŒû
kn-aut-mei=�ÃŒá
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰ÈŠw‹³Žº
en-keyword=Long-term bone marrow culture
kn-keyword=Long-term bone marrow culture
en-keyword=Human marrow stromal cells
kn-keyword=Human marrow stromal cells
en-keyword=Aging
kn-keyword=Aging
en-keyword=Growing dynamics
kn-keyword=Growing dynamics
en-keyword=Cytokine production
kn-keyword=Cytokine production
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=5-6
article-no=
start-page=513
end-page=526
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical investigation of ventricular direct interaction in valvular heart diseases before and after surgery by means of the equilibrium radionuclide ventriculography
kn-title=Œã“V�«•Ù–ŒŽ¾Š³‚ÌŽè�p‘OŒã‚É‚¨‚¯‚é�¶Žº‚ƉEŽº‚Ì’¼�Ú“I‘ŠŒÝ�ì—p‚ÉŠÖ‚·‚錤‹†�\ RI �Sƒv�[ƒ‹–@‚ð—p‚¢‚Ä�\
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To elucidate direct ventricular interaction, equilibrium radionuclide ventriculography was performed on 18 cases of aortic regurgitation (AR) and 31 cases of mitral stenosis(MS) before and after open heart surgery. Patients with AR were divided into two groups by preoperative left ventricular volume : the normovolumic left ventricle (n-LV) group and the dilated left ventricle (d-LV) group. Patients with MS were divided into two groups by preoperative right ventricular volume : the normovolumic right ventricle (n-RV) group and the dilated rihgt ventricle (d-RV) group. In patients with AR, preoperative right ventricular systolic function in the d-LV group was significantly impaired compared with that in the n-LV group. Postoperative right ventricular systolic function in the d-LV group improved to show no significant difference compared to that in the n-LV group because surgery alleviated the left ventricular dilatation. In patients with MS, preoperative left ventricular systolic and diastolic functions in the d-RV group were significantly impaired compared with that of n-RV group. In d-RV group, postoperative left ventricular systolic and diastolic functions were significantly improved wheh right ventricular dilatation could be relieved postoperatively. In the present study, the existence of direct ventricular interaction influenced by the volume-overloaded ventricle was clarified.
en-copyright=
kn-copyright=

en-aut-name=ArakiKazuhiro
en-aut-sei=Araki
en-aut-mei=Kazuhiro
kn-aut-name=�r–؈ꔎ
kn-aut-sei=�r–Ø
kn-aut-mei=ˆê”Ž
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñŠO‰ÈŠw‹³Žº
en-keyword=Œã“V�«•Ù–ŒŽ¾Š³
kn-keyword=Œã“V�«•Ù–ŒŽ¾Š³
en-keyword=RI �Sƒv�[ƒ‹–@
kn-keyword=RI �Sƒv�[ƒ‹–@
en-keyword=�¶Žº‹@”\
kn-keyword=�¶Žº‹@”\
en-keyword=‰EŽº‹@”\
kn-keyword=‰EŽº‹@”\
en-keyword=�SŽºŠÔ’¼�Ú“I‘ŠŒÝ�ì—p
kn-keyword=�SŽºŠÔ’¼�Ú“I‘ŠŒÝ�ì—p
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=5-6
article-no=
start-page=461
end-page=471
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=1994
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=HTLV-‡T infection in patients with pneumoconiosis in regard to complications of malignancy
kn-title=�o”x�Ç‚É‚¨‚¯‚éHTLV-‡TŠ´�õ‚ÌŒŸ“¢�\ˆ«�«ŽîᇂƂ̊֘A‚ðŠÜ‚ß‚Ä�\
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The pathogenesis of pneumocniosis following exposure to inorganic dust remains obscure. HTLV-‡T, known as a cause of adult T cell leukemia, has been reported to participate in various interstitial lung diseases. So, HTLV-‡T infection in patients with pneumoconiosis was inves-tigated by detecting anti-HTLV-‡T antibodies by the indirect immunofluorescent methoh and the pX gene by polymerase chain reaction (PCR) and Southern blotting. Furthermore, various malignancies in pneumoconiosis were also analyzed in relation to HTLV-‡T infection. Three of 24 patients (12.5%) demonstrated anti-HTLV-‡T antibodies. Four of 5 patients includ-ing the 3 patients with antibodies demonstrated the pX gene. Various malignant diseases including myelodyspastic syndrome and lung cancer showed a higher incidence in patients with HTLV-‡T infection than in those without HTLV-‡T infection. These findings indicate that HTLV-‡T infection could play an important role in the path-ogenesis of pneumoconiosis and complications of malignancy.
en-copyright=
kn-copyright=

en-aut-name=SasakiTakashi
en-aut-sei=Sasaki
en-aut-mei=Takashi
kn-aut-name=�²�X–Ø�‚
kn-aut-sei=�²�X–Ø
kn-aut-mei=�‚
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰ÈŠw‹³Žº
en-keyword=�o”x�Ç
kn-keyword=�o”x�Ç
en-keyword=HTLV-‡T (human T-lymphotropic virus type ‡T)
kn-keyword=HTLV-‡T (human T-lymphotropic virus type ‡T)
en-keyword=ŠÔ�ÚŒuŒõ�R‘Ì–@
kn-keyword=ŠÔ�ÚŒuŒõ�R‘Ì–@
en-keyword=–Ɖu“dŒ°–@
kn-keyword=–Ɖu“dŒ°–@
en-keyword=PCR (polymerase chain reaction method)�@–@
kn-keyword=PCR (polymerase chain reaction method)�@–@
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=1-2
article-no=
start-page=127
end-page=134
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on anti-HTLV-‡T antibody in interstitial lung diseases Part 2. Anti-HTLV-‡TIgG, IgM, and IgA antibodies in HTLV-‡T associated bronchiolo-alveolar disorder (HABA)
kn-title=ŠÔŽ¿�«”xŽ¾Š³‚É‚¨‚¯‚é�R HTLV-‡T�R‘Ì‚ÉŠÖ‚·‚錤‹†�@‘æ2•Ò HTLV-‡TŠÖ˜A�׋CŠÇŽx¥”x–EˆÙ�í�Ç (HABA) ‚É‚¨‚¯‚é�R HTLV-‡TIgG, IgM, IgA �R‘Ì‚ÉŠÖ‚·‚錟“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To study the pathogenesis of HTLV-‡Tassociated bronchiolo-alveolar disorder (HABA), Western blot analysis was performed using MT-2 cell lysate antigens on the serum of 6 patients with HABA, 7 patients with adult T cell leukamia (ATL), 14 asymptomatic carriers and 9 healthy controls. Five(83%) of the 6 HABA patients were positive for anti-HTLV-‡T IgA antibodies, although all 7 ATL patients and 11 of the 14 asymptomatic carriers were negative. All HABA and ATL patients and asymptomatic carriers were positive for anti-HTLV-‡T IgG antibodies. Four(67%) of the 6 HABA patients, 2(29%) of the 7 ATL patients and 9(64%) of the 14 asymptomatic carriers were positive for anti-HTLV-‡T IgM antibodies. Statistically there was little difference in the incidences of anti-HTLV-‡T IgG and IgM antibodies among HABA and ATL patients and asymptomatic carriers, but the HABA patients showed a significantly higher incedence of IgA antibody than the ATL patients and asymptomatic carriers. Since specific IgA antibodies are produced in the local infected mucosa and part of the IgA antibodies are transferred into the serum, in conclusion, the anti-HTLV-‡T IgA antibodies in HABA patients reflect the localization of HTLV-‡T in lungs which play an important role in the pathogenesis of HABA.
en-copyright=
kn-copyright=

en-aut-name=UenoKatsumi
en-aut-sei=Ueno
en-aut-mei=Katsumi
kn-aut-name=�A–ì�Ž–¤
kn-aut-sei=�A–ì
kn-aut-mei=�Ž–¤
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰ÈŠw‹³Žº
en-keyword=HTLV-‡TŠÖ˜A�׋CŠÇŽx�E”x–EˆÙ�í�Ç
kn-keyword=HTLV-‡TŠÖ˜A�׋CŠÇŽx�E”x–EˆÙ�í�Ç
en-keyword=�R HTLV-‡TIgA �R‘Ì
kn-keyword=�R HTLV-‡TIgA �R‘Ì
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=1-2
article-no=
start-page=119
end-page=126
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on anti-HTLV-‡T antibody in interstitial lung diseases Part 1. Western blot analysis for anti-HTLV-‡T antibody and HTLV-‡T related reaction in DBP and IIP
kn-title=ŠÔŽ¿�«”xŽ¾Š³‚É‚¨‚¯‚é�R HTLV-‡T�R‘Ì‚ÉŠÖ‚·‚錤‹†�@‘æ1•Ò DPB, IIP‚É‚¨‚¯‚é�R HTLV-‡T�R‘Ì•À‚Ñ‚É HTLV-‡TŠÖ˜A”½‰ž‚Ì Western blot –@‚É‚æ‚錟“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By the immunofluorescent assay for the anti-HTLV-‡T antibody, the serum of many patients with diffuse panbronchiolitis (DBP) and idiopathic interstitial pneumonia (IIP) show two types of cytoplasmic fluorescence. One is a granular pattern in the MT-1 cell and diffuse pattern in the MT-2 cell. This is the typical pattern for the anti-HTLV-‡T antibody. The other is a diffuse pattern in the MT-1 and/or MT-2 cells. This pattern has been designated as HTLV-‡T related reaction. These serum reactions were investigated by Western blot analysis with an MT-2 cell lysate as antigen. Although about 20% of the patients with DBP and IIP were considered to be suffering from HTLV-‡T associated bronchiolo-alveolar disorder (HABA) because they showed the typical pattern of anti-HTLV-‡T antibody, only those patients with HABA were shown to have the antibodies against HTLV-‡T specific proteins (p19, p24, p28, pr53 and gp68). On the other hand, the patients with HTLV-‡T related reaction had neither the antibodies against any HTLV-‡T proteins nor the other protein components of MT-2. Thus, Western blot analysis revealed that antibodies against HTLV-‡T specific proteins were present only in the patients with HABA.
en-copyright=
kn-copyright=

en-aut-name=UenoKatsumi
en-aut-sei=Ueno
en-aut-mei=Katsumi
kn-aut-name=�A–ì�Ž–¤
kn-aut-sei=�A–ì
kn-aut-mei=�Ž–¤
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰ÈŠw‹³Žº
en-keyword=‚Ñ‚Ü‚ñ�«”Ä�׋CŠÇŽx‰Š
kn-keyword=‚Ñ‚Ü‚ñ�«”Ä�׋CŠÇŽx‰Š
en-keyword=“Á”­�«ŠÔŽ¿�«”x‰Š
kn-keyword=“Á”­�«ŠÔŽ¿�«”x‰Š
en-keyword=HTLV-‡T�R‘Ì
kn-keyword=HTLV-‡T�R‘Ì
en-keyword=HTLV-‡TŠÖ˜A”½‰ž
kn-keyword=HTLV-‡TŠÖ˜A”½‰ž
en-keyword=Western blot –@
kn-keyword=Western blot –@
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=9-10
article-no=
start-page=859
end-page=869
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ADF in the lung tissues of HTLV-I associated bronchiolo-alveolar disorder : HABA
kn-title=HTLV-I ŠÖ˜A�׋CŠÇŽx�E”x–EˆÙ�í�Ç (HABA) ‚É‚¨‚¯‚é”x‘g�D’† ADF ‚ÌŒŸ“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=ATL-derived factor (ADF) is an acid protein, molecular weight about 13KD, which is related to cell classification, activation, and various viral infections. The localization of ADF was studied in the lung tissues of HTLV-I associated bronchiolo-alveolar disorder : HABA, diffuse panbronchiolitis : DPB, and idiopathic interstitial pneumonia : IIP. The localization of ADF in the lung tissues was demonstrated by immunohistochemical staining with anti-ADF antibody as the first antibody, which was made by affinity purification. In all 4 cases of HABA, one of 6 cases of DPB, and two of 5 cases of IIP, staining of the lung tissue was positive. ADF was demonstrated in the bronchial epithelia, alveolar epithelia, vascular endothelia, and desquamative cells in HABA cases as the result of the study. ADF was also restrictively demonstrated in bronchial epithelia in DPB and IIP cases. The case of DPB in which ADF was demonstrated also showed positive HTLV-I related reaction. In conclusion, the localization of ADF in the lung tissues was demonstrated in HABA, DPB and IIP, suggesting immunological abnormalities based upon infections from HTLV-I or a related retrovirus.
en-copyright=
kn-copyright=

en-aut-name=KitamuraTomoki
en-aut-sei=Kitamura
en-aut-mei=Tomoki
kn-aut-name=–k‘º’qŽ÷
kn-aut-sei=–k‘º
kn-aut-mei=’qŽ÷
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰ÈŠw‹³Žº
en-keyword=HTLV-I Associated Bronchiolo-alveolar Disorder : HABA
kn-keyword=HTLV-I Associated Bronchiolo-alveolar Disorder : HABA
en-keyword=ATL-derived factor : ADF
kn-keyword=ATL-derived factor : ADF
en-keyword=Diffuse panbronchiolitis
kn-keyword=Diffuse panbronchiolitis
en-keyword=Idiopathic interstitial pneumonia
kn-keyword=Idiopathic interstitial pneumonia
en-keyword=Anti HTLV-I antibody
kn-keyword=Anti HTLV-I antibody
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=715
end-page=731
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=HLA-DNA-DQ typing by PCR-RFLP method in renal transplantation
kn-title=PCR-RFLP –@‚É‚æ‚é HLA-DNA-DQ ƒ^ƒCƒsƒ“ƒO‚Æ�tˆÚ�A
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Two methods of HLA-DNA typing (PCR-RFLP method and PCR-SSO method) were performed on HLA-DQ in living related, living unrelated and cadaveric renal transplants. These two DNA typing methods allowed more accurate and more detailed typing than the conventional typing method. The effect of DNA histocompatibility of DQA 1 and DQB 1, both typed by the PCR-RFLP method, on clinical outcome and surviving graft rate of renal transplant patients was analyzed. There was no correlation found between the number of mismatches between donor and recipient of DQA 1 typing in cadaveric renal transplants, of DQB 1 typing in cadaveric, living unrelated and living related transplants and the clinical outcome nor the surviving graft rate of renal transplant patients. Both the clinical outcome and the surviving graft rate in the group in which DQ 5 mismatch between donor and recipient was positive were statistically poorer than that in the group in which DQ 5 mismatch was negative. This result suggests the existance of DQ 5 mismatch between donor and recipient greatly influences graft survival after renal transplantation.
en-copyright=
kn-copyright=

en-aut-name=HirakawaKeiichi
en-aut-sei=Hirakawa
en-aut-mei=Keiichi
kn-aut-name=•½�ìŒbˆê
kn-aut-sei=•½�ì
kn-aut-mei=Œbˆê
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆêŠO‰ÈŠw‹³Žº
en-keyword=HLA-DNA ƒ^ƒCƒsƒ“ƒO
kn-keyword=HLA-DNA ƒ^ƒCƒsƒ“ƒO
en-keyword=PCR-RFLP –@
kn-keyword=PCR-RFLP –@
en-keyword=PCR-SSO –@
kn-keyword=PCR-SSO –@
en-keyword=�tˆÚ�A
kn-keyword=�tˆÚ�A
en-keyword=DQ �RŒ´
kn-keyword=DQ �RŒ´
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=7-8
article-no=
start-page=681
end-page=693
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=199308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Correlation of vectorcardiographic findings with patterns of left ventricular hypertrophy in hypertrophic cardiomyopathy
kn-title=”ì‘åŒ^�S‹Ø�Ç‚É‚¨‚¯‚é”ì‘å—lŽ®‚ƃxƒNƒgƒ‹�S“d�}‚̑Δ䌟“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We compared vectorcardiographic (VCG) findings with the distribution of hypertrophy in patients with hypertrophic cardiomyopathy (HCM). Distribution of left ventricular hypertrophy was determined by both echocardiogram (UCG) and magnetic resonance imaging (MRI). According to the specific hypertrophic site evaluated by UCG and MRI, 43 patients with HCM were classified into 4 types : septal, anterior, posterolateral or apical type. In patients classified as anterior, posterolateral and apical types, the QRS loop was directed toward the hypertrophic site because of increased electromotive force in the hypertrophic site. In contrast, in patients classified as septal types, the QRS loop was directed away from the hypertrophic site. This opposite direction was probably due to altered electromotive force and/or conduction disturbance in the hypertrophic site as the disease progressed. The present study indicates that QRS loop direction suggests the location of hypertrophy. The T loop was most slender in patients with apical hypertrophy and the slenderness was associated with the relative degree of hypertrophy in the apex compared with hypertrophy in other sites.
en-copyright=
kn-copyright=

en-aut-name=ShirakiTeruo
en-aut-sei=Shiraki
en-aut-mei=Teruo
kn-aut-name=”’–Ø�Æ•v
kn-aut-sei=”’–Ø
kn-aut-mei=�ƕv
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰ÈŠw‹³Žº
en-keyword=ƒxƒNƒgƒ‹�S“d�}
kn-keyword=ƒxƒNƒgƒ‹�S“d�}
en-keyword=”ì‘åŒ^�S‹Ø�Ç
kn-keyword=”ì‘åŒ^�S‹Ø�Ç
en-keyword=�S‘Ÿ’´‰¹”g
kn-keyword=�S‘Ÿ’´‰¹”g
en-keyword=magnetic resonance imaging
kn-keyword=magnetic resonance imaging
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=7-8
article-no=
start-page=789
end-page=798
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199408
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Human T-lymphotropic virus type-‡Tinfection and pulmonary fibrosing changes in patients with lung cancer
kn-title=”xŠàŠ³ŽÒ‚É‚¨‚¯‚é HTLV-‡TŠ´�õ‚ÆŠÔŽ¿�«”x•a•Ï‚ÉŠÖ‚·‚錤‹†
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Thirty-one patients with lung cancer in Okinawa known as HTLV-‡Tendemic area, and 140 patients in Okayama were evaluated in regard to HTLV-‡Tinfection and iterstitial pulmonary shadows. The presence of HTLV-‡Tinfection was examined by the polymerase chain reaction (PCR) method in peripheral blood mononuclear cells, and indirect immunofluorescent (IF) assay in sera. Interstitial pulmonary shadows on the chest roentgenograph, were classified according to the grade of fibrosis. The rate of HTLV-‡Tinfection in patients with lung cancer was higher than that in healthy controls by IF assay in both districts. The rate of anti-HTLV-‡Tantibody was higher in lung cancer patients with severe fibrosis than in those with milder fibrosis, but the grade of fibrosis and existence of pX gene had no relation in Okinawa or in Okayama. The incidence of patients with anti-HTLV-‡Tantibody was higher in patients with adenocarcinoma and squamous cell carcinoma than in those with small cell carcinoma. These findings suggested that HTLV-‡Tinfection was closely involved in some patients with non-small cell lung cancer having intersitital pulmonary shadows.
en-copyright=
kn-copyright=

en-aut-name=NanbaSeiji
en-aut-sei=Nanba
en-aut-mei=Seiji
kn-aut-name=“ï”g–õŽ¡
kn-aut-sei=“ï”g
kn-aut-mei=–õŽ¡
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰ÈŠw‹³Žº
en-keyword=”xŠà
kn-keyword=”xŠà
en-keyword=‚Ñ‚Ü‚ñ�«ŠÔŽ¿�«”x•a•Ï
kn-keyword=‚Ñ‚Ü‚ñ�«ŠÔŽ¿�«”x•a•Ï
en-keyword=polymerase chain reaction
kn-keyword=polymerase chain reaction
en-keyword=ŠÔ�ÚŒuŒõ�R‘Ì–@
kn-keyword=ŠÔ�ÚŒuŒõ�R‘Ì–@
en-keyword=HTLV-‡T
kn-keyword=HTLV-‡T
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=3-6
article-no=
start-page=97
end-page=105
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=19960629
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effect of granulocyte colony-stimulating factor (G-CSF) on allogeneic immune responses
kn-title=è÷—±‹…ƒRƒ�ƒj�[ŽhŒƒˆöŽq‚Ì“¯Ží–Ɖu‰ž“š‚É‹y‚Ú‚·‰e‹¿
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The administration of recombinant human granulocyte colony-stimulating factor (rhG-CSF) increased weight and cellularity of the spleen, leukocyte and granulocyte count of the peripheral blood in a dose- and duration-dependent fashion in mice. When spleen cells as well as serum from mice treated with intraperitoneal injection of 200ƒÊg/‡s of rhG-CSF daily for 7 days were added to an allogeneic mixed lymphocyte reaction (MLR) culture, MLR was significantly suppressed nonspecifically and in a dose-dependent fashion. MLR was also suppressed by adding supernatant of spleen cells using transwells, indicating that suppression was mediated by soluble factor (s) secreted from the spleen cells. The producer cells of the inhibiting factor were found in more mature granulocytes with a high density in the spleen. These results suggested that the proliferated granulocytes induced by G-CSF produced and released factor (s) that suppress allogeneic immune responses.
en-copyright=
kn-copyright=

en-aut-name=UeyamaSatoshi
en-aut-sei=Ueyama
en-aut-mei=Satoshi
kn-aut-name=�ãŽRãà
kn-aut-sei=�ãŽR
kn-aut-mei=ãà
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆêŠO‰ÈŠw‹³Žº
en-keyword=è÷—±‹…ƒRƒ�ƒj�[ŽhŒƒˆöŽq(granulocyte colony-stimulating factor ; G-CSF)
kn-keyword=è÷—±‹…ƒRƒ�ƒj�[ŽhŒƒˆöŽq(granulocyte colony-stimulating factor ; G-CSF)
en-keyword=“¯Ží–Ɖu‰ž“š
kn-keyword=“¯Ží–Ɖu‰ž“š
en-keyword=–Ɖu—}�§
kn-keyword=–Ɖu—}�§
en-keyword=ƒŠƒ“ƒp‹…�¬�‡”½‰ž
kn-keyword=ƒŠƒ“ƒp‹…�¬�‡”½‰ž
END

start-ver=1.4
cd-journal=joma
no-vol=114
cd-vols=
no-issue=3
article-no=
start-page=283
end-page=288
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20030131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunohistchemical Study of Fas in Primary Biliary Cirrhosis
kn-title=Œ´”­�«’_�`�«ŠÌ�d•ÏŠÌ‘g�D‚É‚¨‚¯‚é Fas ”­Œ»‚̖Ɖu‘g�D‰»Šw“IŒŸ“¢
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The expression of Fas on the epithelial cells of bile ducts was examined in liver specimens from 10 patients with primary biliary cirrhosis (PBC), and 14 patients with chronic hepatitis by both light and electron microscopy using the indirect peroxidase-labeled antibody method. In all patients with PBC, Fas was observed on the surface of epithelial cells of interlobular bile ducts. By electron microscopy, electron-dense reaction products of Fas were detected on the basolateral plasma membrane of the bile duct epithelial cells, as well as on some membranes of the endoplasmic reticulum. Fas was expressed more strongly on the surface of the epitherial cells of interlobular bile ducts in PBC than of those in chronic hepatitis. These findings suggest that increased expression of Fas on such bila ducts may play some role in the pathogenesis of PBC.
en-copyright=
kn-copyright=

en-aut-name=KishiFumitoshi
en-aut-sei=Kishi
en-aut-mei=Fumitoshi
kn-aut-name=‹MŽu•¶�r
kn-aut-sei=‹MŽu
kn-aut-mei=•¶�r
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry
en-keyword=Fas
kn-keyword=Fas
en-keyword=apoptosis
kn-keyword=apoptosis
en-keyword=liver
kn-keyword=liver
en-keyword=primary biliary cirrhosis
kn-keyword=primary biliary cirrhosis
en-keyword=immunoelectron microscopy
kn-keyword=immunoelectron microscopy
END

start-ver=1.4
cd-journal=joma
no-vol=115
cd-vols=
no-issue=1
article-no=
start-page=9
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ƒvƒ�ƒAƒNƒ�ƒVƒ“Œ‹�‡ƒ^ƒ“ƒpƒN sp32 ‘O‹ì‘̂̃qƒgƒzƒ‚ƒ�ƒOˆâ“`Žq‚Ì“¯’è‚Æ‚ª‚ñ�E�¸‘ƒ (CT) �RŒ´�|‰ªŽR‘åŠwˆãŠw�Ü�i—ÑŒ´�Ü�j‚ðŽó�Ü‚µ‚Ä�|
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=�¬–ì�r˜N
kn-aut-sei=�¬–ì
kn-aut-mei=�r˜N
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•Šw‘��‡Œ¤‹†‰È�@–ƉuŠw
en-keyword=OY-TES-1
kn-keyword=OY-TES-1
en-keyword=sp32
kn-keyword=sp32
en-keyword=Cancer/testis�iCT�jantigen
kn-keyword=Cancer/testis�iCT�jantigen
en-keyword=Sperm protein
kn-keyword=Sperm protein
en-keyword=Cancer
kn-keyword=Cancer
END

start-ver=1.4
cd-journal=joma
no-vol=116
cd-vols=
no-issue=3
article-no=
start-page=229
end-page=234
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=‹CŠÇŽxšb‘§‚É‚¨‚¯‚é�‚•ª‰ð”\CT (high-resolution computed tomography) ‚É‚æ‚é•]‰¿‚Ì—L—p�«�\‰ªŽR‘åŠwˆãŠw�Ü�i�»“c�Ü�j‚ðŽó�Ü‚µ‚Ä�\
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=‹CŠÇŽxšb‘§‚Í‹C“¹‚Ì–��«‰Š�Ç�«Ž¾Š³‚Å‚ ‚è, –{Ž¿“I‚ɉ‹t�«�áŠQ‚Æ�l‚¦‚ç‚ê‚邪, Ž�‘±“I–��«‰Š�Ç‚É‚æ‚Á‚Ä�¶‚¸‚é”xŽÀŽ¿‚ðŠÜ‚Þ‹C“¹‚̊펿“I•Ï‰»‚·‚È‚í‚¿‹C“¹ƒŠƒ‚ƒfƒŠƒ“ƒO‚ªŒ´ˆö‚Å•s‰Â‹t�«‹C—¬�§ŒÀ‚ð‚«‚½‚µ“¾‚邱‚Æ‚ª’m‚ç‚ê‚Ä‚¢‚é. �Å‹ß, �‚•ª‰ð”\CT (HRCT; high-resolution computed tomography) ‚É‚æ‚Á‚Ä‹CŠÇŽx•Ç”ìŒú, ‹CŠÇŽxŠg’£, ‹CŽî‰», ƒ‚ƒUƒCƒN�ó’á‹zŽûˆæ‚Ȃǂ̕ω»‚Ì•]‰¿‚ª‰Â”\‚Å‚ ‚邱‚Æ‚ª•ñ��‚³‚ê‚Ä‚¢‚é. ‹CŠÇŽxšb‘§Š³ŽÒ‚Ì‹C“¹•Ç‚ÍŒ’�íŽÒ‚É”äŠr‚µ‚Ä”ìŒú‚µ‚Ä‚¨‚è, ‚»‚Ì”ìŒú‚Ì’ö“x‚Íšb‘§‚Ì�d�Ç“x, ‹C—¬�§ŒÀ, ‹C“¹”½‰ž�«‚ÉŠÖ˜A‚µ‚Ä‚¢‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚Ä‚¢‚é. ‹C“¹ƒŠƒ‚ƒfƒŠƒ“ƒO‚𔽉f‚·‚éHRCT‚̈Ù�í�ŠŒ©‚Í, –��«‹C—¬�§ŒÀ‚ð—L‚·‚é�d�Çšb‘§Š³ŽÒ‚É‚¨‚¢‚Ä‚µ‚΂µ‚ΔF‚ß‚ç‚ê, ’·Šú‚Ìœë•aŠúŠÔ‚â‹­‚¢‹C“¹‰Š�Ç‚ÆŠÖŒW‚·‚é‚Æ‚³‚ê‚Ä‚¢‚é. ‰ä�X‚Í, HRCT‚É‚¨‚¯‚é-950Hounsfield unit (HU) ˆÈ‰º‚Ìlow attenuation area (RA(950)) ‚Í”ñ‹i‰Œšb‘§Š³ŽÒ‚É‚¨‚¢‚Ä‚àŒŸ�o‚³‚ê, ‹C—¬�§ŒÀ, ”x‹C—Ê, šb‘§‚Ì�d�Ç“x‚Æ‘ŠŠÖ‚µ‚Ä‚¢‚邪, ”xŠgŽU”\‚Æ‚Ì—LˆÓ‚Ì‘ŠŠÖ‚Í”F‚ß‚È‚¢‚±‚Æ‚ð•ñ��‚µ‚Ä‚«‚½. �Å‹ß, ƒtƒ‰ƒNƒ^ƒ‹‰ð�Í‚É‚æ‚Á‚ÄRA(950)‚Í, ‹i‰Œ—ð‚ð—L‚·‚éšb‘§Š³ŽÒ‚Å‚Í‹CŽî�«•Ï‰»‚ðŽ¦‚·‚̂ɑ΂µ, ”ñ‹i‰Œšb‘§Š³ŽÒ‚Å‚Í”ñ‹CŽî�«•Ï‰» (‰ß–c’£) ‚ðŽ¦‚·‰Â”\�«‚ðŽ¦‚µ‚½. ‚³‚ç‚É, HRCT‚É‚æ‚Á‚Ä•]‰¿‚³‚ꂽ‹C“¹•Ç”ìŒú‚¨‚æ‚ÑRA950‚Í, Ž¡—Âɂæ‚Á‚ĉü‘P‚·‚邱‚Æ‚ª”F‚ß‚ç‚ê‚Ä‚¨‚è, HRCT‚Íšb‘§‚ÌŽ¡—ÃŒø‰Ê”»’è‚É—L—p‚Å‚ ‚é‰Â”\�«‚ªŽ¦�´‚³‚ꂽ.
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en-aut-name=
en-aut-sei=
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kn-aut-name=Œõ‰„•¶—T
kn-aut-sei=Œõ‰„
kn-aut-mei=•¶—T
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•Šw‘��‡Œ¤‹†�Š�@˜V”NˆãŠw
en-keyword=‹CŠÇŽxšb‘§
kn-keyword=‹CŠÇŽxšb‘§
en-keyword=�‚•ª‰ð”\CT
kn-keyword=�‚•ª‰ð”\CT
en-keyword=low attenuation area
kn-keyword=low attenuation area
en-keyword=‹CŠÇŽx•Ç”ìŒú
kn-keyword=‹CŠÇŽx•Ç”ìŒú
en-keyword=‹C“¹ƒŠƒ‚ƒfƒŠƒ“ƒO
kn-keyword=‹C“¹ƒŠƒ‚ƒfƒŠƒ“ƒO
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cd-journal=joma
no-vol=117
cd-vols=
no-issue=2
article-no=
start-page=105
end-page=108
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=20050901
dt-online=
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kn-subject=
en-title=
kn-title=’`”’“±“üƒVƒXƒeƒ€‚É‚æ‚é–ò�ÜŠJ”­‚ÆäX“‡ˆÚ�A‚ւ̉ž—p
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kn-aut-name=–ìŒû—m•¶
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ORCID=

en-aut-name=
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en-aut-mei=
kn-aut-name=�¼‰º�³”V
kn-aut-sei=�¼‰º
kn-aut-mei=�³”V
aut-affil-num=2
ORCID=

en-aut-name=KobayashiNaoya
en-aut-sei=Kobayashi
en-aut-mei=Naoya
kn-aut-name=�¬—Ñ’¼�Æ
kn-aut-sei=�¬—Ñ
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ORCID=

en-aut-name=
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kn-aut-name=SusanBonner-Weir
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kn-aut-mei=Bonner-Weir
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
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kn-aut-name=�¼ˆä�GŽ÷
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ORCID=

en-aut-name=
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ORCID=

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ORCID=

affil-num=1
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kn-affil=‹ž“s‘åŠwˆãŠw•”•�‘®•a‰@ˆÚ�AŠO‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�×–E�¶—�Šw

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�Á‰»Ší�EŽîᇊO‰ÈŠw

affil-num=4
en-affil=
kn-affil=ƒn�[ƒo�[ƒh‘åŠwƒWƒ‡ƒXƒŠƒ““œ”A•aƒZƒ“ƒ^�[

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�×–E�¶—�Šw

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È�Á‰»Ší�EŽîᇊO‰ÈŠw

affil-num=7
en-affil=
kn-affil=�æ’[ˆã—Ã�U‹»�à’c�æ’[ˆã—ÃZƒ“ƒ^�[

affil-num=8
en-affil=
kn-affil=‹ž“s‘åŠwˆãŠw•”•�‘®•a‰@‘ŸŠíˆÚ�Aˆã—Õ”
en-keyword=’`”’“±“üƒVƒXƒeƒ€
kn-keyword=’`”’“±“üƒVƒXƒeƒ€
en-keyword=äX“‡ˆÚ�A
kn-keyword=äX“‡ˆÚ�A
en-keyword=äX“‡�Ä�¶
kn-keyword=äX“‡�Ä�¶
en-keyword=–Ɖu—}�§�Ü
kn-keyword=–Ɖu—}�§�Ü
en-keyword=äX“‡•ª—£‹Z�p
kn-keyword=äX“‡•ª—£‹Z�p
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start-ver=1.4
cd-journal=joma
no-vol=119
cd-vols=
no-issue=3
article-no=
start-page=293
end-page=300
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=III Surgical treatment of lung cancer according to evidence-based clinical practice guidelines
kn-title=III ”x‚ª‚ñ‚ÌŠO‰È“IŽ¡—à �\”xŠà�f—ÃKƒCƒhƒ‰ƒCƒ“‚ð’†�S‚É�\
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kn-copyright=

en-aut-name=SanoYoshifumi
en-aut-sei=Sano
en-aut-mei=Yoshifumi
kn-aut-name=�²–ì—R•¶
kn-aut-sei=�²–ì
kn-aut-mei=—R•¶
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘��‡Œ¤‹†‰È Žîá‡�E‹¹•”ŠO‰ÈŠw
en-keyword=”ñ�¬�×–E”xŠà
kn-keyword=”ñ�¬�×–E”xŠà
en-keyword=ŠO‰È“IŽ¡—Ã
kn-keyword=ŠO‰È“IŽ¡—Ã
en-keyword=‹¹�o‹¾‰ºŽè�p
kn-keyword=‹¹�o‹¾‰ºŽè�p
en-keyword=�pŒãŽ¡—Ã
kn-keyword=�pŒãŽ¡—Ã
en-keyword=�p‘O“±“ü—Ö@
kn-keyword=�p‘O“±“ü—Ö@
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=1
article-no=
start-page=31
end-page=52
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title="The Little Ice Age" and " the General Crisis" of the Early Modern Europe
kn-title=ƒˆ�[ƒ�ƒbƒp‹ß�¢�u�¬•XŠú�v‚Æ‹¤�¶Šë‹@ �\�@‹³�푈�E•´‘ˆ�A•s�ì�A–‚�—Žë‚è�A—¬–¯‚Ì‘½”­‚Í�AŠ¦‚¢‹CŒó‚Ì‚¹‚¢‚©�H�\
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=‚P�D–â‘è‚Ì�Š�Ý�@
‚Q�D�u�¬•XŠú�v‚Ì‘¶�Ý‚Æ‚»‚Ì’è—Ê“Iƒf�[ƒ^‚ðŽ¦‚·Ž©‘R‰ÈŠwŒ¤‹†‚Ì�¬‰Ê�@
‚R�D‹CŒóˆÈŠO‚Ì—vˆö‚ª�l‚¦‚ç‚ê‚È‚¢Ž–�Û‚Ì—á��ƒAƒ‹ƒvƒX‚Ì•X‰Í‚Ì�i�o�@
‚S�D‹CŒó‚ª—L—Í‚È—vˆö‚Æ�l‚¦‚ç‚鎖�Û‚Ì—á��ƒuƒh�[�Í”|‚ ‚é‚¢‚̓�ƒCƒ“�ø‘¢�@
‚T�D�u�¬•X‰ÍŠú�v‚ÌŒ´ˆö‚𑾗zŠˆ“®‚Ì�·�Š‚É‹�‚߂鎩‘R‰ÈŠwŒ¤‹†�@
‚U�D‚Ü‚Æ‚ß‚Æ“W–]�@
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en-aut-name=NagataRyoichi
en-aut-sei=Nagata
en-aut-mei=Ryoichi
kn-aut-name=‰i“c—Ȉê
kn-aut-sei=‰i“c
kn-aut-mei=—Ȉê
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=83
end-page=87
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=19940131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A new scale for student nurses to rate image of the elderly
kn-title=ŠÅŒìŠw�¶‚̘V�lƒCƒ��[ƒW’²�¸‚Ì‚½‚ß‚ÌŽÚ“x�€–Ú‚Ì�\�¬
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Our prior scale for student nurses to rate image of the elderly is inadequate both in number of items used and in exaustiveness of possible images they have. This study attempts to construct a new rating scale by decreasing the number of the previous items and by incorporrating pertinent novel items. A new scale reported here consisits of 20 items, with 15 items being determined through a factor analysisi of the previous 38 items and 5 items being selected after a survey of relevant studies.
en-copyright=
kn-copyright=

en-aut-name=KondoMasuko
en-aut-sei=Kondo
en-aut-mei=Masuko
kn-aut-name=‹ß“¡‰vŽq
kn-aut-sei=‹ß“¡
kn-aut-mei=‰vŽq
aut-affil-num=1
ORCID=

en-aut-name=OhtaNiwa
en-aut-sei=Ohta
en-aut-mei=Niwa
kn-aut-name=‘¾“c‚É‚í
kn-aut-sei=‘¾“c
kn-aut-mei=‚É‚í
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ORCID=

en-aut-name=IkedaToshiko
en-aut-sei=Ikeda
en-aut-mei=Toshiko
kn-aut-name=’r“c•qŽq
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kn-aut-mei=•qŽq
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en-aut-name=MaedaMakiko
en-aut-sei=Maeda
en-aut-mei=Makiko
kn-aut-name=‘O“c�^‹IŽq
kn-aut-sei=‘O“c
kn-aut-mei=�^‹IŽq
aut-affil-num=4
ORCID=

en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=‰i“c”Ž
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kn-aut-mei=”Ž
aut-affil-num=5
ORCID=

en-aut-name=OhtaTakeo
en-aut-sei=Ohta
en-aut-mei=Takeo
kn-aut-name=‘¾“c•�•v
kn-aut-sei=‘¾“c
kn-aut-mei=•�•v
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwˆã—ËZ�p’ZŠú‘åŠw•”ŠÅŒìŠw‰È

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆã—ËZ�p’ZŠú‘åŠw•”ŠÅŒìŠw‰È

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠwˆã—ËZ�p’ZŠú‘åŠw•”ŠÅŒìŠw‰È

affil-num=4
en-affil=
kn-affil=‰ªŽR‘åŠwˆã—ËZ�p’ZŠú‘åŠw•”ŠÅŒìŠw‰È

affil-num=5
en-affil=
kn-affil=‰ªŽR‘åŠwˆã—ËZ�p’ZŠú‘åŠw•”ˆê”Ê‹³ˆç

affil-num=6
en-affil=
kn-affil=‰ªŽR‘åŠwˆã—ËZ�p’ZŠú‘åŠw•”ŠÅŒìŠw‰È
en-keyword=˜V�lŠÅŒì
kn-keyword=˜V�lŠÅŒì
en-keyword=Šw�¶ŽÀ�K
kn-keyword=Šw�¶ŽÀ�K
en-keyword=˜V�lƒCƒ��[ƒWŽÚ“x
kn-keyword=˜V�lƒCƒ��[ƒWŽÚ“x
en-keyword=ˆöŽq•ª�Í
kn-keyword=ˆöŽq•ª�Í
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=34
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=19991220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Interpersonal values in 4-year course nursing students : Comparisons with 3-year course nursing students and students not majoring in nursing science
kn-title=4”N�§ŠÅŒì‰Û’ö“üŠwŽÒ‚Ì‘Î�lŠÖŒW‰¿’l�F3”N�§ŠÅŒìŠw�¶�C”ñŠÅŒìŒnŠw�¶‚Æ‚Ì”äŠr
en-subtitle=
kn-subtitle=
en-abstract=This survey studied the interpersonal values held by a cohort of students admitted to a four-year course of nursing program in 1999 to determine whether they had the
same interpersonal values as the third-year course nursing students. The KG-SIV (Kikuchi-Gordon Survey of Interpersonal Values) was administered twice at the beginning of the program. The subjects described 'self' for the first testing, while they described 'ideal nurse' for the second testing. Their scores on the self and the ideal nurse were compared with those obtained for three cohorts of nursing students who started the three-year course of nursing program in 1990, 1993 and 1996, respectively. Their scores on self were also compared with the scores obtained for four-year course students not majoring in nursing. Analyses showed that compared to the students not majoring in nursing the four-year course nursing students rated the values of Benevolence
and Conformity as more important, while they rated the values of Support, Recognition and Independence as less important. Their scores were simliar to the scores given by the three-year course nursing students. Also, the values of Support and Independence increased while those of Benevolence decreased across the four cohorts of nursing students. It was concluded that nursing students hold distinctive interpersonal values as compared to non-nurses irrespective of their particular nursing program. Such values are ones that are beneficial to the nursing profession.
kn-abstract=1999”N4”N�§ŠÅŒì‰Û’ö‚É“üŠw‚µ‚½ŠÅŒìŠw�¶‚Ì“üŠwŽž‚Ì‘Î�lŠÖŒW‰¿’l‚ðKG-SIV‚É‚æ‚Á‚ÄŒ»ŽÀ‚ÌŽ©ŒÈ‘œ‚ƃi�[ƒX‚Ì—�‘z‘œ‚ɂ‚¢‚Ä’²�¸‚µ�C‚±‚ê‚𓯔N‚É”ñŠÅŒì‰Û’ö‚É“üŠw‚µ‚½Šw�¶‚Æ3”N�§ŠÅŒì‰Û’ö‚ɈقȂ鎞Šú�i1990”N�C1993”N�C1996”N�j‚É“üŠw‚µ‚½ŠÅŒìŠw�¶3ƒRƒz�[ƒg‚Æ”äŠr‚µ‚½�B‚»‚ÌŒ‹‰Ê�C4”N�§ŠÅŒìŠw�¶‚Í”ñŠÅŒìŠw�¶‚É”ä‚×�C�u”Žˆ¤�v‚Æ�u“¯’²�v‚ð�dŽ‹‚·‚é’ö“x‚ª‹­‚­�C�uŽxŽ��v‚Æ�u�³”F�v�C�u“Æ—§�v‚ð�dŽ‹‚·‚é’ö“x‚ªŽã‚©‚Á‚½�B‚Ü‚½�C”Þ�—‚ç
‚Ì‘Î�lŠÖŒW‰¿’l‚Í3”N�§ŠÅŒì‰Û’ö‚ÌŠw�¶‚Ì‚»‚ê‚É—ÞŽ—‚µ‚Ä‚¢‚½�B‚³‚ç‚É�CƒRƒz�[ƒg‚Ì”NŽŸ“IˆÚ�s‚Ì‚È‚©‚ÅŠÅŒìŠw�¶‚Ì‘Î�lŠÖŒW‰¿’l‚Í�uŽxŽ��v‚Æ�u“Æ—§�v‚Ö‚Ì“®‹@‚¯‚ª‘�‘債�C�u”Žˆ¤�v‚Ö‚Ì“®‹@‚¯‚ª–Å‘Þ‚·‚éŒXŒü‚ðŒ©‚¹‚½�B
en-copyright=
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en-aut-name=NagataHiroshi
en-aut-sei=Nagata
en-aut-mei=Hiroshi
kn-aut-name=‰i“c”Ž
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kn-aut-mei=”Ž
aut-affil-num=1
ORCID=

en-aut-name=KatoKumiko
en-aut-sei=Kato
en-aut-mei=Kumiko
kn-aut-name=‰Á“¡‹v”üŽq
kn-aut-sei=‰Á“¡
kn-aut-mei=‹v”üŽq
aut-affil-num=2
ORCID=

en-aut-name=SasanoKanji
en-aut-sei=Sasano
en-aut-mei=Kanji
kn-aut-name=�ù–슮“ñ
kn-aut-sei=�ù–ì
kn-aut-mei=Š®“ñ
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠwŒo�ÏŠw•”

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŠÅŒìŠw�ê�U

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠw–¼—_‹³Žö
en-keyword=‘Î�lŠÖŒW‰¿’l (interpersonal values)
kn-keyword=‘Î�lŠÖŒW‰¿’l (interpersonal values)
en-keyword=ŠÅŒìŠw�¶ (nursing students)
kn-keyword=ŠÅŒìŠw�¶ (nursing students)
en-keyword=ƒRƒz�[ƒg (cohorts)
kn-keyword=ƒRƒz�[ƒg (cohorts)
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=1
article-no=
start-page=139
end-page=146
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=2003
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Development of an Interaction Analysis Support System for asynchronous CSCL
kn-title=”ñ“¯ŠúŒ^CSCL‚É‚¨‚¯‚é‘Θbƒf�[ƒ^•ª�ÍŽx‰‡ƒVƒXƒeƒ€‚ÌŠJ”­
en-subtitle=
kn-subtitle=
en-abstract=Recently, the importance of collaborative learning in school education is coming to be recognized more. And, internet connectivity to each school is proceeding rapidly. By these reasons, much research about CSCL (Computer Support Collaborative Learning) and much collaborative learning on the Web bulletin board in school education are being done. But, a teacher must check each content of the learner's dialogue in detail to analyze learning process in CSCL. This difficutty is one of the bottlenecks of the CSCL using the bulletin board. So, in this research, we develop a support system that supports a teacher to analyze collaborative learning by categorizing the dialog data based on some viewpoints.
kn-abstract=‹ß”N�A�‰“™’†“™‹³ˆç‚â�‚“™‹³ˆç‚É‚¨‚¯‚鋦’²Šw�K‚Ì�d—v�«‚ª‚Ü‚·‚Ü‚·Žw“E‚³‚ê‚é‚悤‚É‚È‚Á‚Ä‚¢‚é�B‚Ü‚½�AŠw�Z‚ւ̃Cƒ“ƒ^�[ƒlƒbƒg�Ú‘±‚ª‹}‘¬‚É�i‚Ý�ACSCL(Computer Supported Collaborative Learning)‚ÉŠÖ‚·‚錤‹†‚ª‘½‚­�s‚í‚ê�AŽÀ‘H‚Å‚àŒfŽ¦”“™‚ðŽg‚Á‚½Web�ã‚Å‚Ì‹¦’²Šw�K‚ª‘½‚­Œ©‚ç‚ê‚é�B‚µ‚©‚µ�AŽö‹ÆŽÀ‘HŽÒ‚ªŠw�KŽÒ‚ÌŠw�K‰ß’ö‚ð•ª�Í‚·‚é�Û�A‘Θb‚Ì—š—ð‚ª•Û‘¶‚³‚ê‚邱‚Æ‚Í‘å‚«‚È—˜“_‚ƂȂ邪�AŠw�KŽÒ‚Ì’mŽ¯�\‘¢‚ª•Ï‰»‚·‚é‰ß’ö‚Æ‚¢‚Á‚½Ž¿“I‚È•ª�Í‚ÍŽö‹ÆŽÀ‘HŽÒ‚ª‘Θb‚Ì“à—e‚ðˆê‚ˆê‚ƒ`ƒFƒbƒN‚µ‚Ä�s‚¤‚µ‚©‚È‚­�A‚±‚Ì�¢“‚ªŒfŽ¦”‚ɂæ‚éCSCLŽÀ‘H‚̃lƒbƒN‚̈ê‚‚ł ‚é‚ÆŒ¾‚¦‚é�B‚»‚±‚Å–{Œ¤‹†‚Å‚Í�AŽö‹ÆŽÀ‘HŽÒ‚ª’~�Ï‚³‚ꂽ‘Θb‚̃f�[ƒ^‚ð‚¢‚­‚‚©‚ÌŠÏ“_‚©‚çƒJƒeƒSƒ‰ƒCƒY‚·‚邱‚Æ‚É‚æ‚Á‚Ä�A‹¦’²Šw�K‚ð—Ê“I�EŽ¿“I‚É•ª�Í‚·‚é‚Ì‚ðŽx‰‡‚·‚éƒVƒXƒeƒ€‚ÌŠJ”­‚ð�s‚¤�B
en-copyright=
kn-copyright=

en-aut-name=KasaiToshinobu
en-aut-sei=Kasai
en-aut-mei=Toshinobu
kn-aut-name=Š}ˆä�r�M
kn-aut-sei=Š}ˆä
kn-aut-mei=�r�M
aut-affil-num=1
ORCID=

en-aut-name=SuzukiMariko
en-aut-sei=Suzuki
en-aut-mei=Mariko
kn-aut-name=—é–Ø�^—�Žq
kn-aut-sei=—é–Ø
kn-aut-mei=�^—�Žq
aut-affil-num=2
ORCID=

en-aut-name=NagataTomoko
en-aut-sei=Nagata
en-aut-mei=Tomoko
kn-aut-name=‰i“c’qŽq
kn-aut-sei=‰i“c
kn-aut-mei=’qŽq
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=‰ªŽR‘åŠw

affil-num=2
en-affil=
kn-affil=‰ªŽR‘åŠw

affil-num=3
en-affil=
kn-affil=‰ªŽR‘åŠw
en-keyword=‹¦’²Šw�K (Collaborative Learning)
kn-keyword=‹¦’²Šw�K (Collaborative Learning)
en-keyword=”ñ“¯ŠúŒ^CSCL (Asynchronous CSCL)
kn-keyword=”ñ“¯ŠúŒ^CSCL (Asynchronous CSCL)
en-keyword=‘Θbƒf�[ƒ^•ª�Í (An Interaction Analysis)
kn-keyword=‘Θbƒf�[ƒ^•ª�Í (An Interaction Analysis)
en-keyword=“dŽqŒfŽ¦” (Bulletin Bord System)
kn-keyword=“dŽqŒfŽ¦” (Bulletin Bord System)
en-keyword=•ª�ÍŽx‰‡ƒVƒXƒeƒ€ (Analysis)
kn-keyword=•ª�ÍŽx‰‡ƒVƒXƒeƒ€ (Analysis)
END

start-ver=1.4
cd-journal=joma
no-vol=81
cd-vols=
no-issue=1
article-no=
start-page=19
end-page=25
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cross-compatibility of Elymus humidus and F1 Hybrid Plants with Triticum and Hordeum
kn-title=ƒ~ƒYƒ^ƒJƒ‚ƒWƒOƒT‚ÌŒðŽG�e˜a�«‚ƃRƒ€ƒM‹y‚уIƒIƒ€ƒM‚Æ‚ÌF1ŽGŽí
en-subtitle=
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