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JaLCDOI 10.18926/AMO/65752
FullText URL 77_4_415.pdf
Author Jelcic, Dzenis| Puzovic, Velibor| Benzon, Benjamin| Palada, Ivan| Jerković, Jelena| Vulic, Marko|
Abstract The aim of our study was to determine whether the immunohistochemical expression of placental vitamin D receptors is altered in pregnancies complicated by preeclampsia. Vitamin D receptor expression was immunohistochemically analysed in the placentas of three groups: a control group, and early- and late-onset preeclampsia groups. Total immunohistochemical intensity staining of placentas showed that the control group had a median vitamin D receptor (VDR) expression significantly higher than the placentas of mothers with early- and late-onset preeclampsia. There was no difference among the three groups in a semiquantitative analysis of VDR staining of the stroma only. Vitamin D receptors showed lower median expression in preeclampsia-affected pregnancies, especially early-onset preeclampsia. Therefore, Vitamin D receptor expression may be an important marker for normal placentation and preeclampsia onset.
Keywords vitamin D receptor immunohistochemistry early and late-onset preeclampsia
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 415
End Page 422
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635142
Web of Science KeyUT 001163659800006
JaLCDOI 10.18926/AMO/65750
FullText URL 77_4_395.pdf
Author Pavlovic, Marko| Babic, Dragan| Rastovic, Pejana| Arapovic, Jurica| Martinac, Marko| Jakovac, Sanja| Barbaric, Romana|
Abstract We investigated the relationship between serum tumor necrosis factor-alpha (TNF-α) levels and psychopathological symptoms, clinical and socio-demographic characteristics and antipsychotic therapy in individuals with schizophrenia. TNF-α levels were measured in 90 patients with schizophrenia and 90 healthy controls matched by age, gender, smoking status, and body mass index. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of psychopathology in patients. No significant differences in TNF-α levels were detected between the patients and controls (p=0.736). TNF-α levels were not correlated with total, positive, negative, general, or composite PANSS scores (all p>0.05). A significant negative correlation was observed between TNF-α levels and the PANSS cognitive factor (ρ=−0.222, p=0.035). A hierarchical regression analysis identified the cognitive factor as a significant predictor of the TNF-α level (beta=−0.258, t=−2.257, p=0.027). There were no significant differences in TNF-α levels among patients treated with different types of antipsychotics (p=0.596). TNF-α levels correlated positively with the age of onset (ρ=0.233, p=0.027) and negatively with illness duration (ρ=−0.247, p=0.019) and antipsychotic treatment duration (ρ=−0.256, p=0.015). These results indicate that TNF-α may be involved in cognitive impairment in schizophrenia, and would be a potential clinical-state marker in schizophrenia.
Keywords tumor necrosis factor-alpha schizophrenia psychopathology immune system
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 395
End Page 405
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635140
Web of Science KeyUT 001163659800010
JaLCDOI 10.18926/AMO/65746
FullText URL 77_4_371.pdf
Author Iwamoto, Yosuke| Kaya, Mitsunori| Kijima, Hiroaki| Fujii, Masashi| Nagahata, Itsuki| Miyakoshi, Naohisa|
Abstract In recent publications on greater trochanteric pain syndrome (GTPS), the pathology receiving the most attention has been gluteus medius muscle tendinous injury, and surgical techniques such as gluteus medius tendon repair and their outcomes for GTPS have been reported. In our department-related facilities, arthroscopic surgeries are routinely performed for the patients with recalcitrant GTPS. A total of 51 patients were diagnosed with GTPS. Surgical treatment was carried out 22 patients (24 joints; 4 males and 18 females; mean age at surgery of 52.0 years). Arthroscopic findings confirmed bursitis in all 24 joints. In all cases, debridement of the greater trochanter bursa provided rapid relief of greater trochanter pain. The Numerical Rating Scale showed significant improvement, from the preoperative mean of 7.8 (range, 6-10) to the postoperative day 7 mean of 1.6 (range, 0-3). The modified Harris Hip Score was significantly improved from the preoperative mean of 65.5 (range, 52.5-78.3) to the final follow-up (average 2.9 months) mean of 96.0 (range, 85.2-100). Fascial damage of the gluteus medius muscle was observed in 21 joints while only 2 patients had a gluteus medius tendinous injury. Greater trochanteric bursitis and fascia or muscle-fiber injury of the gluteus medius muscle are the most common pathologies in patients with lateral hip pain.
Keywords greater trochanteric pain syndrome endoscopic findings bursitis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-08
Volume volume77
Issue issue4
Publisher Okayama University Medical School
Start Page 371
End Page 375
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37635137
Web of Science KeyUT 001163659800005
FullText URL fulltext.pdf
Author Barham, Majd| Kuroda, Masahiro| Yoshimura, Yuuki| Hamada, Kentaro| Khasawneh, Abdullah| Sugimoto, Kohei| Konishi, Kohei| Tekiki, Nouha| Sugianto, Irfan| Bamgbose, Babatunde O.| Ishizaka, Hinata| Shimizu, Yudai| Nakamitsu, Yuki| Al-Hammad, Wlla E.| Kamizaki, Ryo| Kurozumi, Akira| Matsushita, Toshi| Ohno, Seiichiro| Asaumi, Junichi|
Published Date 2023-02-27
Publication Title PLoS ONE
Volume volume18
Issue issue2
Publisher Public Library of Science
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Barham et al.
File Version publisher
PubMed ID 36848353
DOI 10.1371/journal.pone.0282462
Web of Science KeyUT 000996122900036
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0282462
JaLCDOI 10.18926/AMO/65493
FullText URL 77_3_281.pdf
Author Mukai, Yuko| Taira, Naruto| Kajiwara, Yukiko| Iwamoto, Takayuki| Kitaguchi, Yohei| Saiga, Miho| Watanabe, Satoko| Shien, Tadahiko| Doihara, Hiroyoshi| Kimata, Yoshihiro|
Abstract Although immediate breast reconstruction following mastectomy has become increasingly common, its oncological safety has been debated. We enrolled patients with breast cancer who underwent surgery at Okayama University Hospital between 2007 and 2013. The primary outcome was relapse-free survival (RFS). Secondary outcomes were overall survival and the duration from the surgery to the initiation of adjuvant chemotherapy. We divided into immediate breast reconstruction, mastectomy alone, and breast conservative surgery groups. Outcomes were compared using Cox’s regression analysis. A total of 614 patients were included (reconstruction: 125, mastectomy: 128, breast conservative surgery: 361). The median follow-up duration was 79.0±31.9 months. The immediate-reconstruction patients were younger, had more lymph node metastases, and more often received postoperative chemotherapy. The RFS was better after the breast conservative surgery compared to after reconstruction (hazard ratio 0.33, 95% confidence interval: 0.144-0.763). The proportion of local recurrence was highest in the reconstruction group. No patients in the reconstruction group underwent postoperative radiation therapy. However, reconstruction did not affect overall survival or the time to the initiation of adjuvant chemotherapy. Surgeons should explain the risks of breast reconstruction to their patients preoperatively. Careful long-term follow-up is required after such procedures.
Keywords immediate breast reconstruction oncological safety local recurrence postoperative radiation therapy time to initiation of adjuvant chemotherapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 281
End Page 290
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357629
Web of Science KeyUT 001026279600006
JaLCDOI 10.18926/AMO/65491
FullText URL 77_3_263.pdf
Author Guo, Yusheng| Kosaka, Junko| Morimatsu, Hiroshi|
Abstract Continuous renal replacement therapy (CRRT) is widely used to control fluid balance, but the optimal fluid balance to improve the prognosis of patients remains debated. Appropriate fluid management may depend on hemodynamic status. We investigated the association between 90-day mortality and fluid balance/mean arterial pressure (MAP) in patients receiving CRRT. This single-center retrospective study was conducted between May 2018 and March 2021. Based on the cumulative fluid balance at 72 h after initiation of CRRT, the cases were divided into negative (< 0 mL) and positive (> 0 mL) fluid balance groups. Ninety-day mortality was higher in the positive fluid balance group (p=0.009). At 4 h before and after CRRT initiation, the mean MAP was lower in the positive fluid balance group (p<0.05). After multivariate cox adjustment, 72-h positive fluid balance was independently associated with 90-day mortality (p=0.004). In addition, the cumulative fluid balance was associated with 90-day mortality (p<0.05) in cases without shock, high APACHE II score, sepsis, dialysis dependence, or vasopressor use. A 72-h positive fluid balance was associated with 90-day mortality in patients receiving CRRT.
Keywords fluid management continuous renal replacement therapy mortality mean arterial pressure daily cumulative fluid balance
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-06
Volume volume77
Issue issue3
Publisher Okayama University Medical School
Start Page 263
End Page 272
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37357627
Web of Science KeyUT 001026279600004
FullText URL fulltext.pdf
Author Kajiwara, Yuki| Morimoto, Michiko|
Published Date 2023-03-31
Publication Title PLoS ONE
Volume volume18
Issue issue3
Publisher Public Library of Science
Start Page e0283701
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Kajiwara, Morimoto.
File Version publisher
PubMed ID 37000861
DOI 10.1371/journal.pone.0283701
Web of Science KeyUT 000967546000029
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0283701
FullText URL fulltext.pdf
Author Kawanoue, Naoya| Kuroda, Kosuke| Yasuda, Hiroko| Oiwa, Masahiko| Suzuki, Satoshi| Wake, Hidenori| Hosoi, Hiroki| Nishibori, Masahiro| Morimatsu, Hiroshi|
Published Date 2023-03-29
Publication Title PLoS ONE
Volume volume18
Issue issue3
Publisher Public Library of Science
Start Page e0283426
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Kawanoue et al.
File Version publisher
PubMed ID 36989333
DOI 10.1371/journal.pone.0283426
Web of Science KeyUT 000987475800001
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0283426
FullText URL K0006776_abstract_review.pdf K0006776_fulltext.pdf K0006776_summary.pdf
Author ISHIDA, Tomoharu|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6776号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2021 Ishida et al.
FullText URL K0006767_abstract_review.pdf K0006767_fulltext.pdf K0006767_summary.pdf
Author URAGUCHI, Kensuke|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6767号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2021 Uraguchi et al.
FullText URL K0006745_abstract_review.pdf K0006745_fulltext.pdf K0006745_summary.pdf
Author HATTORI, Yasuhiko|
Published Date 2023-03-24
Content Type Thesis or Dissertation
Grant Number 甲第6745号
Granted Date 2023-03-24
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2022 Hattori et al.
FullText URL fulltext.pdf
Author Yamakawa, Michiyo| Tsuda, Toshihide| Wada, Keiko| Nagata, Chisato| Suzuki, Etsuji|
Published Date 2023-02-24
Publication Title PLoS ONE
Volume volume18
Issue issue2
Publisher Public Library of Science
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Yamakawa et al.
File Version publisher
PubMed ID 36827397
DOI 10.1371/journal.pone.0279426
Web of Science KeyUT 000972006100100
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0279426
FullText URL fulltext.pdf
Author Saeki, Nozomu| Yamamoto, Chie| Eguchi, Yuichi| Sekito, Takayuki| Shigenobu, Shuji| Yoshimura, Mami| Yashiroda, Yoko| Boone, Charles| Moriya, Hisao|
Published Date 2023-04-28
Publication Title PLoS Genetics
Volume volume19
Issue issue4
Publisher Public Library of Science
Start Page e1010732
ISSN 1553-7404
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Saeki et al.
File Version publisher
PubMed ID 37115757
DOI 10.1371/journal.pgen.1010732
Web of Science KeyUT 000978623500001
Related Url isVersionOf https://doi.org/10.1371/journal.pgen.1010732
FullText URL fulltext.pdf
Author Shirakawa, Riko| Ishikawa, Kazuya| Furuta, Kazuyuki| Kaito, Chikara|
Published Date 2023-03-24
Publication Title PLoS ONE
Volume volume18
Issue issue3
Publisher Public Library of Science
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Shirakawa et al.
File Version publisher
PubMed ID 36961858
DOI 10.1371/journal.pone.0277162
Web of Science KeyUT 000968067200024
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0277162
FullText URL fulltext.pdf
Author Kyunai, Yuki| Sakamoto, Mika| Koreishi, Mayuko| Tsujino, Yoshio| Satoh, Ayano|
Published Date 2023-02-13
Publication Title PLoS ONE
Volume volume18
Issue issue2
Publisher Public Library of Science
Start Page e0281516
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Kyunai et al.
File Version publisher
PubMed ID 36780470
DOI 10.1371/journal.pone.0281516
Web of Science KeyUT 000966632200001
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0281516
JaLCDOI 10.18926/AMO/65149
FullText URL 77_2_193.pdf
Author Ikeda, Tomohiro| Noma, Kazuhiro| Okura, Kazuki| Katayama, Sho| Takahashi, Yusuke| Maeda, Naoaki| Tanabe, Shunsuke| Wakita, Akiyuki| Hamada, Masanori| Fujiwara, Toshiyoshi| Senda, Masuo|
Abstract This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759). Furthermore, fewer patients whose CS-30 score was greater than 16 (the cutoff value defined based on 6MWT) experienced pneumonia in their postoperative course. These results suggest that exercise tolerance could be assessed using CS-30, and its cutoff value may be useful in predicting postoperative pneumonia risk.
Keywords esophageal cancer exercise tolerance rehabilitation
Amo Type Short Communication
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 193
End Page 197
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094957
Web of Science KeyUT 000982503800009
JaLCDOI 10.18926/AMO/65145
FullText URL 77_2_161.pdf
Author Yamanoi, Tomoko| Suzuki, Satoshi| Kaku, Ryuji| Morimatsu, Hiroshi|
Abstract An intraoperative double-low condition is defined as concurrent low values for bispectral index (BIS) and mean arterial pressure (MAP), and may predict perioperative outcomes. We hypothesized that prolonged double-low times might be associated with an increased incidence of postoperative delirium. We conducted a single-center retrospective observational study on patients who had been admitted to our hospital’s intensive care unit (ICU) after surgery and whose BIS and MAP data had been recorded during general anesthesia. The primary outcome was the incidence of postoperative delirium. A double-low condition was defined as BIS < 45 and MAP <75 mmHg. The total double-low time was calculated in 1-min increments and used to divide the patients into quintiles. Multiple logistic regression analyses were conducted. Among the 334 patients included in the study, the incidence of postoperative delirium was 15.6% (n=52). Multiple logistic regression analysis revealed that a prolonged double-low time, defined as a total double-low time of > 42 min (i.e., third, fourth, and fifth quintiles), was significantly associated with an increased incidence of postoperative delirium (adjusted odds ratio: 2.61, 95% confidence interval: 1.27-5.37, p=0.009). Prolonged double-low time during general anesthesia was independently associated with an increased incidence of postoperative delirium in surgical ICU patients.
Keywords postoperative delirium bispectral index hypotension double-low condition general anesthesia
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 161
End Page 167
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094953
Web of Science KeyUT 000982503800005
JaLCDOI 10.18926/AMO/65143
FullText URL 77_2_139.pdf
Author Namio, Keiichi| Kondo, Takashi| Miyatake, Nobuyuki| Hishii, Shuhei| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Suzuki, Hiromi| Koumoto, Kiichi|
Abstract We investigated the link between prolonged sedentary bouts and all-cause mortality in patients on chronic hemodialysis, using a prospective cohort. A total of 104 outpatients on chronic hemodialysis from 2013 to 2019, aged 71.4±11.4 years, were enrolled. Prolonged sedentary bouts (≥ 30 min and ≥60 min) (min and bouts) and relative prolonged sedentary bouts (≥ 30 min and ≥ 60 min) (%) on the patients’ non-hemodialysis days were measured by a tri-accelerometer, and we also analyzed the patients’ clinical parameters. The relationship between prolonged sedentary bouts and all-cause mortality was evaluated by a survival analysis and the Cox proportional hazard model. Thirty-five patients died during the follow-up period. A Kaplan-Meier analysis detected significant differences in the survival rate between two groups stratified by the median for all prolonged sedentary-bout parameters. After the adjustment for confounding factors, all of the prolonged sedentary-bout parameters were determinant factors for all-cause mortality. These results indicate that prolonged sedentary bouts on non-hemodialysis days were closely related to all-cause mortality in the patients on hemodialysis.
Keywords sedentary bout mortality hemodialysis survival analysis
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2023-04
Volume volume77
Issue issue2
Publisher Okayama University Medical School
Start Page 139
End Page 145
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2023 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 37094951
Web of Science KeyUT 000982503800003
FullText URL fulltext.pdf
Author Yokomizo, Akemi| Nagae, Hiroko| Athurupana, Rukmali| Nakatsuka, Mikiya|
Published Date 2023-03-06
Publication Title PLoS ONE
Volume volume18
Issue issue3
Publisher Public Library of Science
ISSN 1932-6203
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Yokomizo et al.
File Version publisher
PubMed ID 36877696
DOI 10.1371/journal.pone.0281362
Web of Science KeyUT 000945977800034
Related Url isVersionOf https://doi.org/10.1371/journal.pone.0281362
FullText URL fulltext.pdf
Author Wang, Han| Salaipeth, Lakha| Miyazaki, Naoyuki| Suzuki, Nobuhiro| Okamoto, Kenta|
Published Date 2023-02-27
Publication Title PLoS Pathogens
Volume volume19
Issue issue2
Publisher Public Library of Science
Start Page e1011162
ISSN 1553-7366
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2023 Wang et al.
File Version publisher
PubMed ID 36848381
DOI 10.1371/journal.ppat.1011162
Web of Science KeyUT 000942039200002
Related Url isVersionOf https://doi.org/10.1371/journal.ppat.1011162