result 349 件
| FullText URL | fulltext.pdf Figures.pdf Suppl_Material_Methods.pdf Suppl_Figures.pdf Legend_suppl_figures.pdf Suppl_Table.pdf |
|---|---|
| Author | Kajioka, Hiroki| Kagawa, Shunsuke| Ito, Atene| Yoshimoto, Masashi| Sakamoto, Shuichi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model |
| Note | This fulltext is available in January, 2022.| |
| Published Date | 2021-01-28 |
| Publication Title | Cancer Letters |
| Volume | volume497 |
| Publisher | Elsevier |
| Start Page | 1 |
| End Page | 3 |
| ISSN | 0304-3835 |
| NCID | AA00598513 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33065249 |
| DOI | 10.1016/j.canlet.2020.10.015 |
| Web of Science KeyUT | 000596072900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hada, Yoshiko| Uchida, Haruhito A.| Mukai, Tomoyuki| Kojima, Fumiaki| Yoshida, Masashi| Takeuchi, Hidemi| Kakio, Yuki| Otaka, Nozomu| Morita, Yoshitaka| Wada, Jun| |
| Keywords | MR16-1 interleukin-1 receptor antagonist aortitis arthritis LV hypertrophy |
| Note | This is an accepted version of Yoshiko Hada et. al. Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice published in Clinical Science 134(20). For final published version, see https://doi.org/10.1042/CS20201036.| |
| Published Date | 2020-10-30 |
| Publication Title | Clinical Science |
| Volume | volume134 |
| Issue | issue20 |
| Publisher | Portland Press |
| Start Page | 2771 |
| End Page | 2787 |
| ISSN | 0143-5221 |
| NCID | AA00143386 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Authors |
| File Version | author |
| PubMed ID | 33064141 |
| DOI | 10.1042/CS20201036 |
| Web of Science KeyUT | 000587350600004 |
| Related Url | isVersionOf https://doi.org/10.1042/CS20201036 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Hatipoglu, Omer F.| Miyoshi, Toru| Yonezawa, Tomoko| Kondo, Megumi| Amioka, Naofumi| Yoshida, Masashi| Akagi, Satoshi| Nakamura, Kazufumi| Hirohata, Satoshi| Ito, Hiroshi| |
| Keywords | Aneurysm Aortic diseases |
| Published Date | 2020-04-22 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 6869 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32321956 |
| DOI | 10.1038/s41598-020-63824-9 |
| Web of Science KeyUT | 000560329100004 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-63824-9 |
| FullText URL | fulltext.pdf Tables.pdf Fig1.tif Fig2.tif Supplementary Tables.pdf Supplementary Fig.pdf |
|---|---|
| Author | Yamamoto, Hiromasa| Namba, Kei| Yamamoto, Haruchika| Toji, Tomohiro| Soh, Junichi| Shien, Kazuhiko| Suzawa, Ken| Kurosaki, Takeshi| Otani, Shinji| Okazaki, Mikio| Sugimoto, Seiichiro| Yamane, Masaomi| Takahashi, Katsuhito| Kunisada, Toshiyuki| Oto, Takahiro| Toyooka, Shinichi| |
| Keywords | Metastatic lung tumor Sarcoma Metastasectomy Survival rate Neutrophil-to-lymphocyte ratio (NLR) |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-020-02093-5. | |
| Published Date | 2020-08-03 |
| Publication Title | Surgery Today |
| Publisher | Springer |
| ISSN | 0941-1291 |
| NCID | AA10824685 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32747982 |
| DOI | 10.1007/s00595-020-02093-5 |
| Web of Science KeyUT | 000555382600001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00595-020-02093-5 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miyake, Hiromasa| Tanabe, Katsuyuki| Tanimura, Satoshi| Nakashima, Yuri| Morioka, Tomoyo| Masuda, Kana| Sugiyama, Hitoshi| Sato, Yasufumi| Wada, Jun| |
| Keywords | acute kidney injury ischemia-reperfusion oxidative stress vasohibin-2 peritubular capillaries |
| Published Date | 2020-06-26 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue12 |
| Publisher | MDPI |
| Start Page | 4545 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32604722 |
| DOI | 10.3390/ijms21124545 |
| Web of Science KeyUT | 000549478900001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21124545 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Gao, Shangze| Wake, Hidenori| Sakaguchi, Masakiyo| Wang, Dengli| Takahashi, Youhei| Teshigawara, Kiyoshi| Zhong, Hui| Mori, Shuji| Liu, Keyue| Takahashi, Hideo| Nishibori, Masahiro| |
| Published Date | 2020-06-26 |
| Publication Title | iScience |
| Volume | volume23 |
| Issue | issue6 |
| Publisher | Cell Press |
| Start Page | 101180 |
| ISSN | 2589-0042 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32498020 |
| DOI | 10.1016/j.isci.2020.101180 |
| Web of Science KeyUT | 000548236600006 |
| Related Url | isVersionOf https://doi.org/10.1016/j.isci.2020.101180 |
| FullText URL | fulltext.pdf Fig-1.tiff Fig-2.tiff Fig-3.tiff Fig-4.tiff Fig-5.tiff Fig-6.tiff |
|---|---|
| Author | Zhao, Xianglin| Kawano, Shun‐ichiro| Masuda, Junko| Murakami, Hiroshi| |
| Keywords | granulocyte MAP kinase negative feedback phosphorylation scaffold protein SHP2 |
| Published Date | 2020-05-21 |
| Publication Title | Cell Biology International |
| Volume | volume44 |
| Issue | issue9 |
| Publisher | Wiley |
| Start Page | 1919 |
| End Page | 1933 |
| ISSN | 1065-6995 |
| NCID | AA10882014 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32437087 |
| DOI | 10.1002/cbin.11398 |
| Web of Science KeyUT | 000540242400001 |
| Related Url | isVersionOf https://doi.org/10.1002/cbin.11398 |
| JaLCDOI | 10.18926/AMO/57366 |
|---|---|
| FullText URL | 73_5_379.pdf |
| Author | Wake, Hidenori| |
| Abstract | Histidine-rich glycoprotein (HRG) is a 75 kDa glycoprotein synthesized in the liver whose plasma concentration is 100-150 μg/ml. HRG has been shown to modulate sepsis-related biological reactions by binding to several substances and cells, including heparin, factor XII, fibrinogen, thrombospondin, plasminogen, C1q, IgG, heme, LPS, dead cells, bacteria, and fungi. Therefore, reduction of plasma HRG levels in sepsis leads to dysregulation of coagulation, fibrinolysis, and immune response, resulting in disseminated intravascular coagulation and multiple organ failure. This review summarizes the binding and functional properties of HRG in sepsis. |
| Keywords | htidine-rich glycoprotein septic pathogenesis immunothrombosis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 379 |
| End Page | 382 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649362 |
| Web of Science KeyUT | 000491886600001 |
| JaLCDOI | 10.18926/AMO/56933 |
|---|---|
| FullText URL | 73_4_315.pdf |
| Author | Ono, Shintaro| Nakayama, Masaaki| Tachibana, Masato| Abu Saleh Muhammad Shahriar| Heling, Wang| Takashiba, Shogo| Ohara, Naoya| |
| Abstract | The periodontal pathogen Porphyromonas gingivalis shows colonial pigmentation on blood agar and produces gingipains (Kgp, RgpA, and RgpB), cysteine proteases involved in an organism’s virulence and pigmentation. We showed previously that deletion of the PGN_0300 gene abolished the pigmentation activity and reduced the proteolytic activity of gingipains. The role of the PGN_0297 gene, which consists of an operon with the PGN_0300 gene, is unclear. Herein we examined the effect of PGN_0297 gene deletion on the pigmentation and proteolytic activities and transcriptional levels of gingipains. A PGN_0297 gene deletion mutant (ΔPGN_0297) did not exhibit the pigmentation. The proteolytic activity of the gingipains was decreased in the culture supernatant and on the cell surface of ΔPGN_0297. The mutant ΔPGN_0297 failed to attenuate Akt phosphorylation at Thr308 and Ser473, but both phosphorylations were attenuated in the wild-type and its complementation strain. The deletion of PGN_0297 gene did not substantially affect the transcriptional levels of the gingipain genes kgp, rgpA, and rgpB. Taken together, these results indicate that PGN_0297 is closely involved in the secretion and maturation of gingipains. |
| Keywords | periodontitis Porphyromonas gingivalis gingipain C-terminal domain secretion system |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-08 |
| Volume | volume73 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 315 |
| End Page | 323 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31439954 |
| FullText URL | K0005899_abstract_review.pdf K0005899_summary.pdf K0005899_fulltext.pdf |
|---|---|
| Author | SOE SOE HTWE| |
| Published Date | 2019-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5899号 |
| Granted Date | 2019-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/56377 |
|---|---|
| FullText URL | 72_6_591.pdf |
| Author | Shimoyama, Yuichiro| Umegaki, Osamu| Inoue, Satsuki| Agui, Tomoyuki| Kadono, Noriko| Minami, Toshiaki| |
| Abstract | A neutrophil-to-lymphocyte ratio (NLR) > 7 is reportedly an independent marker of mortality in patients with bacteremia. However, no studies have shown an association between inflammation-based prognostic scores (including the Glasgow Prognostic Score, the NLR, the platelet-to-lymphocyte ratio, the Prognostic Nutritional Index, and the Prognostic Index) and mortality in patients with pneumonia. We retrospectively examined the cases of 33 patients diagnosed with pneumonia who were treated in the ICU of Osaka Medical College Hospital between January 2014 and June 2016. A multivariate analysis revealed that the NLR was a significant predictor of mortality in these pneumonia patients. |
| Keywords | inflammation-based prognostic score pneumonia in-hospital mortality |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-12 |
| Volume | volume72 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 591 |
| End Page | 593 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 30573914 |
| NAID | 120006545162 |
| JaLCDOI | 10.18926/AMO/54596 |
|---|---|
| FullText URL | 70_5_377.pdf |
| Author | Kawakami, Yoshio| Katayama, Takashi| Kishida, Masayuki| Oda, Wakako| Inoue, Yasuro| |
| Abstract | A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Direct immunofluorescence showed negative results. Blood culture revealed the growth of gram-negative bacilli. Subsequently, 16S rRNA sequencing of DNA confirmed the organism as Streptobacillus moniliformis, which is the causative pathogen of rat-bite fever. He had frequently encountered wild rats in his house although there was no evidence of rat bite on his body. Empiric therapy with intravenous administration of ceftriaxone in combination with azithromycin hydrate led to a prompt resolution of the symptoms. Precise history-taking related to contact with rats and detection of skin eruptions suggestive of leukocytoclastic vasculitis on the extremities, especially on the feet, can be clues to Streptobacillus moniliformis infection. Familiarity with its cutaneous features is important for early diagnosis; the evidence herein may also help in understanding its underlying pathogenesis. |
| Keywords | livedo vasculitis rat bite fever polyarteritis nodosa septic vasculopathy |
| Amo Type | Case Reports |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-10 |
| Volume | volume70 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 377 |
| End Page | 381 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27777430 |
| Web of Science KeyUT | 000388098700007 |
| FullText URL | K0005261_abstract_review.pdf K0005261_fulltext.pdf |
|---|---|
| Author | Harada, Masaki| |
| Published Date | 2016-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5261号 |
| Granted Date | 2016-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/53024 |
|---|---|
| FullText URL | 68_6_349.pdf |
| Author | Yamamoto, Tsuyoshi| Kajikawa, Yutaka| Otani, Satoru| Yamada, Yuki| Takemoto, Syunji| Hirota, Minoru| Ikeda, Masae| Iwagaki, Hiromi| Saito, Shinya| Fujiwara, Toshiyoshi| |
| Abstract | Accumulated studies have shown that ω-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have protective roles against inflammatory responses such as hyperlipidemia, diabetes mellitus (DM) and cardiovascular diseases. Here we examined the effects of administering EPA to hyperlipidemic patients and other patients undergoing cardiac surgery to determine whether this treatment would increase plasma EPA levels and to clarify the association between EPA treatment and adiponectin production in hyperlipidemic patients. We also assessed the effect of preoperative EPA administration on postoperative adverse events such as postoperative atrial fibrillation (POAF) and postoperative infection in the cardiac surgery patients. The EPA administration significantly increased the serum EPA concentrations in both patient populations (p＜0.001). In the hyperlipidemic patients, the EPA administration significantly increased plasma adiponectin levels (p＜0.05), accompanied by a decrease in insulin resistance designated by the HOMA-IR (homeostasis model assessment of insulin resistance) score (p＜0.05) and Hs-CRP (high sensitivity C-reactive protein) value (p＜0.05). In the cardiac surgery patients, no significant effect of EPA on cardiac adverse events such as POAF was observed. However, our results clearly demonstrated that both the neutrophil-to-lymphocyte ratio and the 2nd-line antibiotic requirement in the EPA group were significantly decreased compared to the untreated control group (p＜0.05). We suggest that EPA administration may exert anti-inflammatory effects in patients with hyperlipidemia and in those undergoing cardiac surgery, possibly through an increase in plasma adiponectin levels. |
| Keywords | eicosapentaenoic acid adiponectin hyperlipidemic patients cardiac surgery atrial fibrillation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-12 |
| Volume | volume68 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 349 |
| End Page | 361 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25519029 |
| Web of Science KeyUT | 000346882200005 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/53125 |
| Author | Sugiyama, Koichi| Sada, Ken-ei| Kurosawa, Michiko| Wada, Jun| Makino, Hirofumi| |
|---|---|
| Published Date | 2013-02 |
| Publication Title | Clinical and Experimental Nephrology |
| Volume | volume17 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Kurimoto, Etsuko| Miyahara, Nobuaki| Kanehiro, Arihiko| Waseda, Koichi| Taniguchi, Akihiko| Ikeda, Genyo| Koga, Hikari| Nishimori, Hisakazu| Tanimoto, Yasushi| Kataoka, Mikio| Iwakura, Yoichiro| Gelfand, Erwin W.| Tanimoto, Mitsune| |
|---|---|
| Published Date | 2013-01-20 |
| Publication Title | Respiratory Research |
| Volume | volume14 |
| Content Type | Journal Article |
| Author | Koga, Hikari| Miyahara, Nobuaki| Fuchimoto, Yasuko| Ikeda, Genyo| Waseda, Koichi| Ono, Katsuichiro| Tanimoto, Yasushi| Kataoka, Mikio| Gelfand, Erwin W.| Tanimoto, Mitsune| Kanehiro, Arihiko| |
|---|---|
| Published Date | 2013-01-24 |
| Publication Title | Respiratory Research |
| Volume | volume14 |
| Content Type | Journal Article |
| FullText URL | K0004811_abstract_review.pdf K0004811_fulltext.pdf |
|---|---|
| Author | Koga, Hikari| |
| Published Date | 2013-06-30 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第4811号 |
| Granted Date | 2013-06-30 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese English |
| Author | Yashiro, Masato| Tsukahara, Hirokazu| Matsukawa, Akihiro| Yamada, Mutsuko| Fujii, Yosuke| Nagaoka, Yoshiharu| Tsuge, Mitsuru| Yamashita, Nobuko| Ito, Toshihiro| Yamada, Masao| Masutani, Hiroshi| Yodoi, Junji| Morishima, Tsuneo| |
|---|---|
| Published Date | 2013-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Shimzu, K.| Takahashi, T.| Iwasaki, T.| Shimizu, H.| Inoue, K.| Morimatsu, H.| Omori, E.| Matsumi, M.| Akagi, R.| Morita, K.| |
|---|---|
| Published Date | 2008-11 |
| Publication Title | Medicinal Chemistry |
| Volume | volume4 |
| Issue | issue6 |
| Content Type | Journal Article |
