start-ver=1.4
cd-journal=joma
no-vol=177
cd-vols=
no-issue=4
article-no=
start-page=e70396
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=CNGC2 Negatively Regulates Stomatal Closure and Is Not Required for flg22- and H2O2-Induced Guard Cell [Ca2+]cyt Elevation in Arabidopsis thaliana
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In guard cells, cytosolic Ca2+ acts as a second messenger that mediates abscisic acid (ABA)- and pathogen-associated molecular pattern (PAMP)-induced stomatal closure. It was reported that Arabidopsis cyclic nucleotide-gated ion channel 2 (CNGC2) functions as hydrogen peroxide (H2O2)- and PAMP-activated Ca2+-permeable channels at the plasma membrane of mesophyll cells and mediates Ca2+-dependent PAMP-triggered immunity. In this study, we examined the role of CNGC2 in the regulation of stomatal movement because CNGC2 is also expressed in guard cells. We found that stomata of the CNGC2 disruption mutant cngc2-3 are constitutively closed even in the absence of ABA or the flagellar-derived PAMP, flg22. Consistently, leaf temperatures of the cngc2-3 mutant were higher than those of wild-type (WT) plants. The stomatal phenotype of the cngc2-3 mutant was restored by complementation with wild-type CNGC2 under the control of the guard cell preferential promoter, pGC1. Elevation of cytosolic free Ca2+ concentration in guard cells induced by flg22 and H2O2 remained intact in the cngc2-3 mutant. The introduction of the ost1-3 mutation into the cngc2-3 background did not alter the stomatal phenotype. However, the stomatal phenotype of the cngc2-3 mutant was successfully rescued in the double disruption mutant cngc2-3aba2-2. Taken together, these results suggest that CNGC2 negatively regulates stomatal closure response and does not function as flg22– and H2O2-activated Ca2+ channels in guard cells. Though CNGC2 is responsive for H2O2- and flg22-induced [Ca2+]cyt elevation in mesophyll cells, the involvement of CNGC2 in the response to H2O2 and flg22 in guard cells is questionable.
en-copyright=
kn-copyright=

en-aut-name=AkterRojina
en-aut-sei=Akter
en-aut-mei=Rojina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=InoueYasuhiro
en-aut-sei=Inoue
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MasumotoSaori
en-aut-sei=Masumoto
en-aut-mei=Saori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MimataYoshiharu
en-aut-sei=Mimata
en-aut-mei=Yoshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsuuraTakakazu
en-aut-sei=Matsuura
en-aut-mei=Takakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MoriIzumi C.
en-aut-sei=Mori
en-aut-mei=Izumi C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakamuraToshiyuki
en-aut-sei=Nakamura
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Faculty of Agriculture, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=6
en-affil=
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=10
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=calcium signaling
kn-keyword=calcium signaling
en-keyword=CNGC
kn-keyword=CNGC
en-keyword=stomata
kn-keyword=stomata
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=7
article-no=
start-page=808
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=20250630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Carnosol, a Rosemary Ingredient Discovered in a Screen for Inhibitors of SARM1-NAD+ Cleavage Activity, Ameliorates Symptoms of Peripheral Neuropathy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) is a nicotinamide adenine dinucleotide (NAD+) hydrolase involved in axonal degeneration and neuronal cell death. SARM1 plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic brain injury, and neurodegenerative diseases. Importantly, SARM1 knockdown or knockout prevents the degeneration; as a result, SARM1 has been attracting attention as a potent therapeutic target. In recent years, the development of several SARM1 inhibitors derived from synthetic chemical compounds has been reported; however, no dietary ingredients with SARM1 inhibitory activity have been identified. Therefore, we here focused on dietary ingredients and found that carnosol, an antioxidant contained in rosemary, inhibits the NAD+-cleavage activity of SARM1. Purified carnosol inhibited the enzymatic activity of SARM1 and suppressed neurite degeneration and cell death induced by the anti-cancer medicine vincristine (VCR). Carnosol also inhibited VCR-induced hyperalgesia symptoms, suppressed the loss of intra-epidermal nerve fibers in vivo, and reduced the blood fluid level of phosphorylated neurofilament-H caused by an axonal degeneration event. These results indicate that carnosol has a neuroprotective effect via SARM1 inhibition in addition to its previously known antioxidant effect via NF-E2-related factor 2 and thus suppresses neurotoxin-induced peripheral neuropathy.
en-copyright=
kn-copyright=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OgawaKazuki
en-aut-sei=Ogawa
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YasuiYu
en-aut-sei=Yasui
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OchiToshiki
en-aut-sei=Ochi
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamamotoKen-Ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=WadaYoji
en-aut-sei=Wada
en-aut-mei=Yoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakamuraHiromichi
en-aut-sei=Nakamura
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=NishiboriMasahiro
en-aut-sei=Nishibori
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Tama Biochemical Co., Ltd.
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Tama Biochemical Co., Ltd.
kn-affil=

affil-num=9
en-affil=Tama Biochemical Co., Ltd.
kn-affil=

affil-num=10
en-affil=Department of Translational Research and Drug Development, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=SARM1
kn-keyword=SARM1
en-keyword=carnosol
kn-keyword=carnosol
en-keyword=NAD+
kn-keyword=NAD+
en-keyword=axon degeneration
kn-keyword=axon degeneration
en-keyword=peripheral neuropathy
kn-keyword=peripheral neuropathy
END

start-ver=1.4
cd-journal=joma
no-vol=197
cd-vols=
no-issue=
article-no=
start-page=115301
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2025
dt-pub=202503
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fraglide-1 from traditional Chinese aromatic vinegar: A natural AhR antagonist for atopic dermatitis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Traditional Chinese Zhenjiang aromatic vinegar (Kozu) contains Fraglide-1 (FG1), a bioactive lactone with demonstrated peroxisome proliferator-activated receptor gamma (PPARγ) agonist and antioxidant activities. This study explored FG1's novel ability to antagonize the aryl hydrocarbon receptor (AhR) signaling pathway, which regulates artemin expression and contributes to itching and inflammation in atopic dermatitis. Through molecular docking simulations and cell-based assays in human keratinocytes, we demonstrated FG1's potent antagonistic activity against AhR signaling. FG1 effectively suppressed FICZ-induced inflammatory responses, including artemin expression, with potency (half maximal inhibitory concentration, IC50 = 5.1 μM) comparable to the synthetic antagonist StemRegenin 1 (SR1) while demonstrating a superior safety profile (median lethal concentration, LC50 > 100 μM vs. 27.5 μM for SR1). These findings expand our understanding of bioactive compounds from traditional fermented foods and their regulatory effects on AhR signaling, providing a foundation for future studies on FG1's role in modulating skin inflammation.
en-copyright=
kn-copyright=

en-aut-name=KatoKosuke
en-aut-sei=Kato
en-aut-mei=Kosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AkamatsuMiki
en-aut-sei=Akamatsu
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KakimaruSaya
en-aut-sei=Kakimaru
en-aut-mei=Saya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KoreishiMayuko
en-aut-sei=Koreishi
en-aut-mei=Mayuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakagiMasahiro
en-aut-sei=Takagi
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyashitaMasahiro
en-aut-sei=Miyashita
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SatohAyano
en-aut-sei=Satoh
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TsujinoYoshio
en-aut-sei=Tsujino
en-aut-mei=Yoshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=School of Materials Science, Japan Advanced Institute of Science and Technology
kn-affil=

affil-num=6
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=10
en-affil=Graduate School of Science, Technology and Innovation, Kobe University
kn-affil=
en-keyword=AhR
kn-keyword=AhR
en-keyword=Xenobiotic responsive element
kn-keyword=Xenobiotic responsive element
en-keyword=StemRegenin 1
kn-keyword=StemRegenin 1
en-keyword=ARNT
kn-keyword=ARNT
en-keyword=Atopic dermatitis
kn-keyword=Atopic dermatitis
en-keyword=Artemin
kn-keyword=Artemin
END

start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=16
article-no=
start-page=9038
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240820
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Quercetin Attenuates Acetaldehyde-Induced Cytotoxicity via the Heme Oxygenase-1-Dependent Antioxidant Mechanism in Hepatocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=It is still unclear whether or how quercetin influences the toxic events induced by acetaldehyde in hepatocytes, though quercetin has been reported to mitigate alcohol-induced mouse liver injury. In this study, we evaluated the modulating effect of quercetin on the cytotoxicity induced by acetaldehyde in mouse hepatoma Hepa1c1c7 cells, the frequently used cellular hepatocyte model. The pretreatment with quercetin significantly inhibited the cytotoxicity induced by acetaldehyde. The treatment with quercetin itself had an ability to enhance the total ALDH activity, as well as the ALDH1A1 and ALDH3A1 gene expressions. The acetaldehyde treatment significantly enhanced the intracellular reactive oxygen species (ROS) level, whereas the quercetin pretreatment dose-dependently inhibited it. Accordingly, the treatment with quercetin itself significantly up-regulated the representative intracellular antioxidant-related gene expressions, including heme oxygenase-1 (HO-1), glutamate-cysteine ligase, catalytic subunit (GCLC), and cystine/glutamate exchanger (xCT), that coincided with the enhancement of the total intracellular glutathione (GSH) level. Tin protoporphyrin IX (SNPP), a typical HO-1 inhibitor, restored the quercetin-induced reduction in the intracellular ROS level, whereas buthionine sulphoximine, a representative GSH biosynthesis inhibitor, did not. SNPP also cancelled the quercetin-induced cytoprotection against acetaldehyde. These results suggest that the low-molecular-weight antioxidants produced by the HO-1 enzymatic reaction are mainly attributable to quercetin-induced cytoprotection.
en-copyright=
kn-copyright=

en-aut-name=LiKexin
en-aut-sei=Li
en-aut-mei=Kexin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KidawaraMinori
en-aut-sei=Kidawara
en-aut-mei=Minori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ChenQiguang
en-aut-sei=Chen
en-aut-mei=Qiguang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakamuraToshiyuki
en-aut-sei=Nakamura
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=quercetin
kn-keyword=quercetin
en-keyword=acetaldehyde
kn-keyword=acetaldehyde
en-keyword=glutathione
kn-keyword=glutathione
en-keyword=aldehyde dehydrogenase
kn-keyword=aldehyde dehydrogenase
en-keyword=heme oxygenase-1
kn-keyword=heme oxygenase-1
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=
article-no=
start-page=1403922
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240820
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Lentil adaptation to drought stress: response, tolerance, and breeding approaches
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Lentil (Lens culinaris Medik.) is a cool season legume crop that plays vital roles in food and nutritional security, mostly in the least developed countries. Lentil is often cultivated in dry and semi-dry regions, where the primary abiotic factor is drought, which negatively impacts lentil growth and development, resulting in a reduction of yield. To withstand drought-induced multiple negative effects, lentil plants evolved a variety of adaptation strategies that can be classified within three broad categories of drought tolerance mechanisms (i.e., escape, avoidance, and tolerance). Lentil adapts to drought by the modulation of various traits in the root system, leaf architecture, canopy structure, branching, anatomical features, and flowering process. Furthermore, the activation of certain defensive biochemical pathways as well as the regulation of gene functions contributes to lentil drought tolerance. Plant breeders typically employ conventional and mutational breeding approaches to develop lentil varieties that can withstand drought effects; however, little progress has been made in developing drought-tolerant lentil varieties using genomics-assisted technologies. This review highlights the current understanding of morpho-physiological, biochemical, and molecular mechanisms of lentil adaptation to drought stress. We also discuss the potential application of omics-assisted breeding approaches to develop lentil varieties with superior drought tolerance traits.
en-copyright=
kn-copyright=

en-aut-name=NoorMd. Mahmud Al
en-aut-sei=Noor
en-aut-mei=Md. Mahmud Al
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Tahjib-Ul-ArifMd.
en-aut-sei=Tahjib-Ul-Arif
en-aut-mei=Md.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AlimS. M. Abdul
en-aut-sei=Alim
en-aut-mei=S. M. Abdul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IslamMd. Mohimenul
en-aut-sei=Islam
en-aut-mei=Md. Mohimenul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HasanMd. Toufiq
en-aut-sei=Hasan
en-aut-mei=Md. Toufiq
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=BabarMd. Ali
en-aut-sei=Babar
en-aut-mei=Md. Ali
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HossainMohammad Anwar
en-aut-sei=Hossain
en-aut-mei=Mohammad Anwar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=JewelZilhas Ahmed
en-aut-sei=Jewel
en-aut-mei=Zilhas Ahmed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MostofaMohammad Golam
en-aut-sei=Mostofa
en-aut-mei=Mohammad Golam
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Plant Breeding Division, Bangladesh Institute of Nuclear Agriculture
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Plant Breeding Division, Bangladesh Institute of Nuclear Agriculture
kn-affil=

affil-num=4
en-affil=Horticulture Division, Bangladesh Institute of Nuclear Agriculture
kn-affil=

affil-num=5
en-affil=Department of Biotechnology, Bangladesh Agricultural University
kn-affil=

affil-num=6
en-affil=Agronomy Departments, University of Florida
kn-affil=

affil-num=7
en-affil=Department of Genetics and Plant Breeding, Bangladesh Agricultural University
kn-affil=

affil-num=8
en-affil=Faculty of Agriculture, Bangabandhu Sheikh Mujibur Rahman Science and Technology University
kn-affil=

affil-num=9
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Biochemistry and Molecular Biology, Michigan State University
kn-affil=
en-keyword=abiotic stress
kn-keyword=abiotic stress
en-keyword=morphology
kn-keyword=morphology
en-keyword=pulse crop
kn-keyword=pulse crop
en-keyword=plant growth
kn-keyword=plant growth
en-keyword=omics
kn-keyword=omics
en-keyword=water-deficit
kn-keyword=water-deficit
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=10
article-no=
start-page=1138
end-page=1149
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240606
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Compiling evidence has indicated that S100A11 expression at high levels is closely associated with various cancer species. Consistent with the results reported elsewhere, we have also revealed that S100A11 is highly expressed in squamous cell carcinoma, mesothelioma, and pancreatic cancers and plays a crucial role in cancer progression when secreted into extracellular fluid. Those studies are all focused on the extracellular role of S100A11. However, most of S100A11 is still present within cancer cells, although the intracellular role of S100A11 in cancer cells has not been fully elucidated. Thus, we aimed to investigate S100A11 functions within cancer cells, primarily focusing on colorectal cancer cells, whose S100A11 is abundantly present in cells and still poorly studied cancer for the protein. Our efforts revealed that overexpression of S100A11 promotes proliferation and migration, and downregulation inversely dampens those cancer behaviors. To clarify how intracellular S100A11 aids cancer cell activation, we tried to identify S100A11 binding proteins, resulting in novel binding partners in the inner membrane, many of which are desmosome proteins. Our molecular approach defined that S100A11 regulates the expression level of DSG1, a component protein of desmosome, by which S100A11 activates the TCF pathway via promoting nuclear translocation of γ-catenin from the desmosome. The identified new pathway greatly helps to comprehend S100A11’s nature in colorectal cancers and others.
en-copyright=
kn-copyright=

en-aut-name=ZhouJin
en-aut-sei=Zhou
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MizutaNaoko
en-aut-sei=Mizuta
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamakawaAtsuko
en-aut-sei=Yamakawa
en-aut-mei=Atsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=S100A11
kn-keyword=S100A11
en-keyword=Desmosome
kn-keyword=Desmosome
en-keyword=TCF signaling
kn-keyword=TCF signaling
en-keyword=Colorectal cancer
kn-keyword=Colorectal cancer
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=1371307
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240528
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background Triple-negative breast cancer (TNBC) cells are a highly formidable cancer to treat. Nonetheless, by continued investigation into the molecular biology underlying the complex regulation of TNBC cell activity, vulnerabilities can be exposed as potential therapeutic targets at the molecular level. We previously revealed that lysyl oxidase-like 4 (LOXL4) promotes the invasiveness of TNBC cells via cell surface annexin A2 as a novel binding substrate of LOXL4, which promotes the abundant localization of integrin-beta 1 at the cancer plasma membrane. However, it has yet to be uncovered how the LOXL4-mediated abundance of integrin-beta 1 hastens the invasive outgrowth of TNBC cells at the molecular level.<br>
Methods LOXL4-overexpressing stable clones were established from MDA-MB-231 cells and subjected to molecular analyses, real-time qPCR and zymography to clarify their invasiveness, signal transduction, and matrix metalloprotease (MMP) activity, respectively.<br>
Results Our results show that LOXL4 potently promotes the induction of matrix metalloprotease 9 (MMP9) via activation of nuclear factor-kappa B (NF-kappa B). Our molecular analysis revealed that TNF receptor-associated factor 4 (TRAF4) and TGF-beta activated kinase 1 (TAK1) were required for the activation of NF-kappa B through I kappa beta kinase kinase (IKK alpha/beta) phosphorylation.<br>
Conclusion Our results demonstrate that the newly identified LOXL4-mediated axis, integrin-beta 1-TRAF4-TAK1-IKK alpha/beta-I kappa beta alpha-NF-kappa B-MMP9, is crucial for TNBC cell invasiveness.
en-copyright=
kn-copyright=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KomalasariNi Luh Gede Yoni
en-aut-sei=Komalasari
en-aut-mei=Ni Luh Gede Yoni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Kasano-CamonesCarlos Ichiro
en-aut-sei=Kasano-Camones
en-aut-mei=Carlos Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NinomiyaKazumi
en-aut-sei=Ninomiya
en-aut-mei=Kazumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamamotoKen-Ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=GoharaYuma
en-aut-sei=Gohara
en-aut-mei=Yuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OchiToshiki
en-aut-sei=Ochi
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=RumaI. Made Winarsa
en-aut-sei=Ruma
en-aut-mei=I. Made Winarsa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SumardikaI. Wayan
en-aut-sei=Sumardika
en-aut-mei=I. Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=ZhouJin
en-aut-sei=Zhou
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=HonjoTomoko
en-aut-sei=Honjo
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=SakaguchiYoshihiko
en-aut-sei=Sakaguchi
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=KuribayashiFutoshi
en-aut-sei=Kuribayashi
en-aut-mei=Futoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=FutamiJunichiro
en-aut-sei=Futami
en-aut-mei=Junichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=KondoEisaku
en-aut-sei=Kondo
en-aut-mei=Eisaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=6
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=7
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=13
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=14
en-affil=Medical Oncology Department of Gastrointestinal Tumors, Liaoning Cancer Hospital & Institute, Cancer Hospital of the Dalian University of Technology
kn-affil=

affil-num=15
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=16
en-affil=Department of Microbiology, Tokushima Bunri University
kn-affil=

affil-num=17
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=18
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=19
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=20
en-affil=Division of Tumor Pathology, Near InfraRed Photo-Immuno-Therapy Research Institute, Kansai Medical University
kn-affil=

affil-num=21
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=22
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=23
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=invasion
kn-keyword=invasion
en-keyword=lysyl oxidase
kn-keyword=lysyl oxidase
en-keyword=NF-κB
kn-keyword=NF-κB
en-keyword=MMP9
kn-keyword=MMP9
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=2
article-no=
start-page=88
end-page=97
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Enhancing effect of the coexisting alpha-tocopherol on quercetin absorption and metabolism
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study is to investigate the modulating effect of coexisting food components on the absorption and metabolism of quercetin and blood plasma antioxidant potentials. The combination of quercetin with α-tocopherol (αT), cellulose, or a commercially available vegetable beverage containing αT and dietary fiber was orally administered to mice. Compared to the single administration of quercetin aglycone, the coadministration of αT with quercetin significantly increased the plasma quercetin concentration at 0.5 h, whereas the combination of quercetin and cellulose decreased it. Interestingly, the administration of quercetin mixed with the vegetable beverage showed no significant change in the quercetin concentration in the mice plasma. The treatment of the cells with the blood plasma after the coadministration of αT with quercetin significantly upregulated the gene expression of the antioxidant enzyme (heme oxygenase-1), whereas the quercetin and cellulose combination did not. In the plasma of the quercetin-administered mice, eight types of quercetin metabolites were detected, and their quantities were affected by the combination with αT. The potentials of the heme oxygenase-1 gene expression by these metabolites were very limited, although several metabolites showed radical scavenging activities comparable to aglycone in the in vitro assays. These results suggested that the combination of αT potentiates the quercetin absorption and metabolism and thus the plasma antioxidant potentials, at least in part, by the quantitative changes in the quercetin metabolites.
en-copyright=
kn-copyright=

en-aut-name=MitsuzaneRikito
en-aut-sei=Mitsuzane
en-aut-mei=Rikito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkuboReiko
en-aut-sei=Okubo
en-aut-mei=Reiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishikawaMiyu
en-aut-sei=Nishikawa
en-aut-mei=Miyu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IkushiroShinichi
en-aut-sei=Ikushiro
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakamuraToshiyuki
en-aut-sei=Nakamura
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University
kn-affil=

affil-num=4
en-affil=Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=quercetin
kn-keyword=quercetin
en-keyword=metabolite
kn-keyword=metabolite
en-keyword=absorption
kn-keyword=absorption
en-keyword=metabolism
kn-keyword=metabolism
en-keyword=antioxidant activity
kn-keyword=antioxidant activity
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=4
article-no=
start-page=431
end-page=447
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230304
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The adenovirus-REIC/Dkk-3 expression vector (Ad-REIC) has been the focus of numerous clinical studies due to its potential for the quenching of cancers. The cancer-suppressing mechanisms of the REIC/DKK-3 gene depend on multiple pathways that exert both direct and indirect effects on cancers. The direct effect is triggered by REIC/Dkk-3-mediated ER stress that causes cancer-selective apoptosis, and the indirect effect can be classified in two ways: (i) induction, by Ad-REIC-mis-infected cancer-associated fibroblasts, of the production of IL-7, an important activator of T cells and NK cells, and (ii) promotion, by the secretory REIC/Dkk-3 protein, of dendritic cell polarization from monocytes. These unique features allow Ad-REIC to exert effective and selective cancer-preventative effects in the manner of an anticancer vaccine. However, the question of how the REIC/Dkk-3 protein leverages anticancer immunity has remained to be answered. We herein report a novel function of the extracellular REIC/Dkk-3—namely, regulation of an immune checkpoint via modulation of PD-L1 on the cancer-cell surface. First, we identified novel interactions of REIC/Dkk-3 with the membrane proteins C5aR, CXCR2, CXCR6, and CMTM6. These proteins all functioned to stabilize PD-L1 on the cell surface. Due to the dominant expression of CMTM6 among the proteins in cancer cells, we next focused on CMTM6 and observed that REIC/Dkk-3 competed with CMTM6 for PD-L1, thereby liberating PD-L1 from its complexation with CMTM6. The released PD-L1 immediately underwent endocytosis-mediated degradation. These results will enhance our understanding of not only the physiological nature of the extracellular REIC/Dkk-3 protein but also the Ad-REIC-mediated anticancer effects.
en-copyright=
kn-copyright=

en-aut-name=GoharaYuma
en-aut-sei=Gohara
en-aut-mei=Yuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FutamiJunichiro
en-aut-sei=Futami
en-aut-mei=Junichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AudebertLéna
en-aut-sei=Audebert
en-aut-mei=Léna
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KomalasariNi Luh Gede Yoni
en-aut-sei=Komalasari
en-aut-mei=Ni Luh Gede Yoni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YoshizawaChikako
en-aut-sei=Yoshizawa
en-aut-mei=Chikako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=WatanabeMasami
en-aut-sei=Watanabe
en-aut-mei=Masami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KumonHiromi
en-aut-sei=Kumon
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=11
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=12
en-affil=Department of Urology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=13
en-affil=Innovation Center Okayama for Nanobio-Targeted Therapy, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Cell Biology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=Breast cancer
kn-keyword=Breast cancer
en-keyword=REIC/Dkk-3
kn-keyword=REIC/Dkk-3
en-keyword=PD-L1
kn-keyword=PD-L1
en-keyword=Immune checkpoint
kn-keyword=Immune checkpoint
en-keyword=Cancer therapy
kn-keyword=Cancer therapy
END

start-ver=1.4
cd-journal=joma
no-vol=174
cd-vols=
no-issue=6
article-no=
start-page=533
end-page=548
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230919
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) is a NAD+ hydrolase that plays a key role in axonal degeneration and neuronal cell death. We reported that c-Jun N-terminal kinase (JNK) activates SARM1 through phosphorylation at Ser-548. The importance of SARM1 phosphorylation in the pathological process of Parkinson’s disease (PD) has not been determined. We thus conducted the present study by using rotenone (an inducer of PD-like pathology) and neurons derived from induced pluripotent stem cells (iPSCs) from healthy donors and a patient with familial PD PARK2 (FPD2). The results showed that compared to the healthy neurons, FPD2 neurons were more vulnerable to rotenone-induced stress and had higher levels of SARM1 phosphorylation. Similar cellular events were obtained when we used PARK2-knockdown neurons derived from healthy donor iPSCs. These events in both types of PD-model neurons were suppressed in neurons treated with JNK inhibitors, Ca2+-signal inhibitors, or by a SARM1-knockdown procedure. The degenerative events were enhanced in neurons overexpressing wild-type SARM1 and conversely suppressed in neurons overexpressing the SARM1-S548A mutant. We also detected elevated SARM1 phosphorylation in the midbrain of PD-model mice. The results indicate that phosphorylated SARM1 plays an important role in the pathological process of rotenone-induced neurodegeneration.
en-copyright=
kn-copyright=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=PhooMay Tha Zin
en-aut-sei=Phoo
en-aut-mei=May Tha Zin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OchiToshiki
en-aut-sei=Ochi
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyazakiIkuko
en-aut-sei=Miyazaki
en-aut-mei=Ikuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NishiboriMasahiro
en-aut-sei=Nishibori
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AsanumaMasato
en-aut-sei=Asanuma
en-aut-mei=Masato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Translational Research and Drug Development, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=JNK
kn-keyword=JNK
en-keyword=PARK2
kn-keyword=PARK2
en-keyword=Parkinson’sdisease
kn-keyword=Parkinson’sdisease
en-keyword=Phosphorylation
kn-keyword=Phosphorylation
en-keyword=SARM1
kn-keyword=SARM1
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=1371342
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2024
dt-pub=20240326
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Our earlier research revealed that the secreted lysyl oxidase-like 4 (LOXL4) that is highly elevated in triple-negative breast cancer (TNBC) acts as a catalyst to lock annexin A2 on the cell membrane surface, which accelerates invasive outgrowth of the cancer through the binding of integrin-β1 on the cell surface. However, whether this machinery is subject to the LOXL4-mediated intrusive regulation remains uncertain.<br>
<br>
Methods: Cell invasion was assessed using a transwell-based assay, protein–protein interactions by an immunoprecipitation–Western blotting technique and immunocytochemistry, and plasmin activity in the cell membrane by gelatin zymography.<br>
<br>
Results: We revealed that cell surface annexin A2 acts as a receptor of plasminogen via interaction with S100A10, a key cell surface annexin A2-binding factor, and S100A11. We found that the cell surface annexin A2/S100A11 complex leads to mature active plasmin from bound plasminogen, which actively stimulates gelatin digestion, followed by increased invasion.<br>
<br>
Conclusion: We have refined our understanding of the role of LOXL4 in TNBC cell invasion: namely, LOXL4 mediates the upregulation of annexin A2 at the cell surface, the upregulated annexin 2 binds S100A11 and S100A10, and the resulting annexin A2/S100A11 complex acts as a receptor of plasminogen, readily converting it into active-form plasmin and thereby enhancing invasion.
en-copyright=
kn-copyright=

en-aut-name=TakahashiTetta
en-aut-sei=Takahashi
en-aut-mei=Tetta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamamotoKen-Ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KomalasariNi Luh Gede Yoni
en-aut-sei=Komalasari
en-aut-mei=Ni Luh Gede Yoni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=GoharaYuma
en-aut-sei=Gohara
en-aut-mei=Yuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OchiToshiki
en-aut-sei=Ochi
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=RumaI. Made Winarsa
en-aut-sei=Ruma
en-aut-mei=I. Made Winarsa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SumardikaI. Wayan
en-aut-sei=Sumardika
en-aut-mei=I. Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=ZhouJin
en-aut-sei=Zhou
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=HonjoTomoko
en-aut-sei=Honjo
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=SakaguchiYoshihiko
en-aut-sei=Sakaguchi
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=KuribayashiFutoshi
en-aut-sei=Kuribayashi
en-aut-mei=Futoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=KondoEisaku
en-aut-sei=Kondo
en-aut-mei=Eisaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=FutamiJunichiro
en-aut-sei=Futami
en-aut-mei=Junichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=ZamamiYoshito
en-aut-sei=Zamami
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=7
en-affil=Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=12
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=13
en-affil=Medical Oncology Department of Gastrointestinal Tumors, Liaoning Cancer Hospital & Institute, Cancer Hospital of the Dalian University of Technology
kn-affil=

affil-num=14
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Microbiology, Tokushima Bunri University
kn-affil=

affil-num=16
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=17
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=18
en-affil=Division of Tumor Pathology, Near InfraRed Photo-Immuno-Therapy Research Institute, Kansai Medical University
kn-affil=

affil-num=19
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=20
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=21
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=22
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=23
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=lysyl oxidase
kn-keyword=lysyl oxidase
en-keyword=annexin A2
kn-keyword=annexin A2
en-keyword=S100A11
kn-keyword=S100A11
en-keyword=plasmin
kn-keyword=plasmin
en-keyword=cancer microenvironment
kn-keyword=cancer microenvironment
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=11
article-no=
start-page=1323
end-page=1331
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230808
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The effect of exogenous dihydroxyacetone and methylglyoxal on growth, anthocyanin accumulation, and the glyoxalase system in Arabidopsis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Dihydroxyacetone (DHA) occurs in wide-ranging organisms, including plants, and can undergo spontaneous conversion to methylglyoxal (MG). While the toxicity of MG to plants is well-known, the toxicity of DHA to plants remains to be elucidated. We investigated the effects of DHA and MG on Arabidopsis. Exogenous DHA at up to 10 mM did not affect the radicle emergence, the expansion of green cotyledons, the seedling growth, or the activity of glyoxalase II, while DHA at 10 mM inhibited the root elongation and increased the activity of glyoxalase I. Exogenous MG at 1.0 mM inhibited these physiological responses and increased both activities. Dihydroxyacetone at 10 mM increased the MG content in the roots. These results indicate that DHA is not so toxic as MG in Arabidopsis seeds and seedlings and suggest that the toxic effect of DHA at high concentrations is attributed to MG accumulation by the conversion to MG.
en-copyright=
kn-copyright=

en-aut-name=ZhaoMaoxiang
en-aut-sei=Zhao
en-aut-mei=Maoxiang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraToshiyuki
en-aut-sei=Nakamura
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MoriIzumi C
en-aut-sei=Mori
en-aut-mei=Izumi C
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=dihydroxyacetone
kn-keyword=dihydroxyacetone
en-keyword=methylglyoxal
kn-keyword=methylglyoxal
en-keyword=growth
kn-keyword=growth
en-keyword=anthocyanin
kn-keyword=anthocyanin
en-keyword=glyoxalase system
kn-keyword=glyoxalase system
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=日本における保育とこどもの発達について
kn-title=Childcare and Child Development in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MURATAAkiko
en-aut-sei=MURATA
en-aut-mei=Akiko
kn-aut-name=村田亜紀子
kn-aut-sei=村田
kn-aut-mei=亜紀子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=7
article-no=
start-page=1438
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230718
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Combined Effect of Salicylic Acid and Proline Mitigates Drought Stress in Rice (Oryza sativa L.) through the Modulation of Physiological Attributes and Antioxidant Enzymes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Salicylic acid (SA) and proline exhibit protective effects against a wide range of stresses. However, the combined impact of SA and proline on rice under drought stress is still unknown. Therefore, we investigated the protective roles of SA and/or proline in conferring drought tolerance in rice. There were eight treatments comprising the control (T1; 95-100% FC), 1.5 mM SA (T2), 2 mM proline (T3), 0.75 mM SA + 1 mM proline (T4), 45-50% FC (T5, drought stress), T5 + 1.5 mM SA (T6), T5 + 2 mM proline (T7), and T5 + 0.75 mM SA + 1 mM proline (T8), and two rice varieties: BRRI dhan66 and BRRI dhan75. Drought stress significantly decreased the plant growth, biomass, yield attributes, photosynthetic rate (Pn), stomatal conductance (gs), transpiration rate (Tr), photosynthetic pigments (chlorophyll and carotenoids content), relative water content (RWC), membrane stability index (MSI), soluble sugar and starch content, and uptake of N, P and K+ in roots and shoots. Drought-induced oxidative stress in the form of increased hydrogen peroxide (H2O2) production and lipid peroxidation (MDA) was observed. The combined application of SA (0.75 mM) + proline (1 mM) was found to be more effective than the single application of either for drought stress mitigation in rice. A combined dose of SA + proline alleviated oxidative stress through boosting antioxidant enzymatic activity in contrast to their separate application. The application of SA + proline also enhanced proline, soluble sugar and starch content, which resulted in the amelioration of osmotic stress. Consequently, the combined application of SA and proline significantly increased the gas exchange characteristics, photosynthetic pigments, RWC, MSI, nutrient uptake, plant growth, biomass and yield of rice. Therefore, the combined application of SA and proline alleviated the detrimental impacts of drought stress more pronouncedly than their separate application did by increasing osmoprotectants, improving nutrient transport, up-regulating antioxidant enzyme activity and inhibiting oxidative stress.
en-copyright=
kn-copyright=

en-aut-name=UrmiTahmina Akter
en-aut-sei=Urmi
en-aut-mei=Tahmina Akter
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IslamMd. Moshiul
en-aut-sei=Islam
en-aut-mei=Md. Moshiul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ZumurKamrun Naher
en-aut-sei=Zumur
en-aut-mei=Kamrun Naher
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AbedinMd. Anwarul
en-aut-sei=Abedin
en-aut-mei=Md. Anwarul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HaqueM. Moynul
en-aut-sei=Haque
en-aut-mei=M. Moynul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SiddiquiManzer H.
en-aut-sei=Siddiqui
en-aut-mei=Manzer H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HoqueMd. Anamul
en-aut-sei=Hoque
en-aut-mei=Md. Anamul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Soil Science, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Agronomy, Faculty of Agriculture, Bangabandhu Sheikh Mujibur Rahman Agricultural University
kn-affil=

affil-num=4
en-affil=Department of Soil Science, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=5
en-affil=Department of Agronomy, Faculty of Agriculture, Bangabandhu Sheikh Mujibur Rahman Agricultural University
kn-affil=

affil-num=6
en-affil=Department of Botany and Microbiology, College of Science, King Saud University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Soil Science, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=
en-keyword=rice
kn-keyword=rice
en-keyword=drought stress
kn-keyword=drought stress
en-keyword=osmolytes
kn-keyword=osmolytes
en-keyword=reactive oxygen species
kn-keyword=reactive oxygen species
en-keyword=lipid peroxidation
kn-keyword=lipid peroxidation
en-keyword=antioxidant
kn-keyword=antioxidant
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=
article-no=
start-page=110717
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=202308
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Nicotinamide adenine dinucleotide (NAD)+-biosynthetic and consuming enzymes are involved in various intracellular events through the regulation of NAD+ metabolism. Recently, it has become clear that alterations in the expression of NAD+-biosynthetic and consuming enzymes contribute to the axonal stability of neurons. We explored soluble bioactive factor(s) that alter the expression of NAD+-metabolizing enzymes and found that cytokine interferon (IFN)-γ increased the expression of nicotinamide nucleotide adenylyltransferase 2 (NMNAT2), an NAD+-biosynthetic enzyme. IFN-γ activated signal transducers and activators of transcription 1 and 3 (STAT1/3) followed by c-Jun N-terminal kinase (JNK) suppression. As a result, STAT1/3 increased the expression of NMNAT2 at both mRNA and protein levels in a dose- and time-dependent manner and, at the same time, suppressed activation of sterile alpha and Toll/interleukin receptor motif-containing 1 (SARM1), an NAD+-consuming enzyme, and increased intracellular NAD+ levels. We examined the protective effect of STAT1/3 signaling against vincristine-mediated cell injury as a model of chemotherapy-induced peripheral neuropathy (CIPN), in which axonal degeneration is involved in disease progression. We found that IFN-γ-mediated STAT1/3 activation inhibited vincristine-induced downregulation of NMNAT2 and upregulation of SARM1 phosphorylation, resulting in modest suppression of subsequent neurite degradation and cell death. These results indicate that STAT1/3 signaling induces NMNAT2 expression while simultaneously suppressing SARM1 phosphorylation, and that both these actions contribute to suppression of axonal degeneration and cell death.
en-copyright=
kn-copyright=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YasuiYu
en-aut-sei=Yasui
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OisoKazuma
en-aut-sei=Oiso
en-aut-mei=Kazuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OchiToshiki
en-aut-sei=Ochi
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=NMNAT2
kn-keyword=NMNAT2
en-keyword=SARM1
kn-keyword=SARM1
en-keyword=NAD+
kn-keyword=NAD+
en-keyword=STAT1/3
kn-keyword=STAT1/3
en-keyword=IFN-γ
kn-keyword=IFN-γ
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=1142907
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: LOX family members are reported to play pivotal roles in cancer. Unlike their enzymatic activities in collagen cross-linking, their precise cancer functions are unclear. We revealed that LOXL4 is highly upregulated in breast cancer cells, and we thus sought to define an unidentified role of LOXL4 in breast cancer.<br>
Methods: We established the MDA-MB-231 sublines MDA-MB-231-LOXL4 mutCA and -LOXL4 KO, which stably overexpress mutant LOXL4 that loses its catalytic activity and genetically ablates the intrinsic LOXL4 gene, respectively. In vitro and in vivo evaluations of these cells’ activities of cancer outgrowth were conducted by cell-based assays in cultures and an orthotopic xenograft model, respectively. The new target (s) of LOXL4 were explored by the MS/MS analytic approach.<br>
Results: Our in vitro results revealed that both the overexpression of mutCA and the KO of LOXL4 in cells resulted in a marked reduction of cell growth and invasion. Interestingly, the lowered cellular activities observed in the engineered cells were also reflected in the mouse model. We identified a novel binding partner of LOXL4, i.e., annexin A2. LOXL4 catalyzes cell surface annexin A2 to achieve a cross-linked multimerization of annexin A2, which in turn prevents the internalization of integrin β-1, resulting in the locking of integrin β-1 on the cell surface. These events enhance the promotion of cancer cell outgrowth.<br>
Conclusions: LOXL4 has a new role in breast cancer progression that occurs via an interaction with annexin A2 and integrin β-1 on the cell surface.<br>
en-copyright=
kn-copyright=

en-aut-name=KomalasariNi Luh Gede Yoni
en-aut-sei=Komalasari
en-aut-mei=Ni Luh Gede Yoni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakaguchiYoshihiko
en-aut-sei=Sakaguchi
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=GoharaYuma
en-aut-sei=Gohara
en-aut-mei=Yuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YamamotoKen-Ich
en-aut-sei=Yamamoto
en-aut-mei=Ken-Ich
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=RumaI Made Winarsa
en-aut-sei=Ruma
en-aut-mei=I Made Winarsa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SumardikaI Wayan
en-aut-sei=Sumardika
en-aut-mei=I Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=ZhouJin
en-aut-sei=Zhou
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KuribayashiFutoshi
en-aut-sei=Kuribayashi
en-aut-mei=Futoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Surgery & Bio-Bank of General Surgery, TheFourth Affiliated Hospital of Harbin Medical University
kn-affil=

affil-num=5
en-affil=Department of Microbiology, Kitasato University School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=11
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=12
en-affil=Medical Oncology Department of Gastrointestinal Tumors, Liaoning Cancer Hospital & Institute, Cancer Hospital of Dalian University of Technology
kn-affil=

affil-num=13
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=14
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=15
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=16
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=17
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=lysyl oxidase
kn-keyword=lysyl oxidase
en-keyword=annexin A2
kn-keyword=annexin A2
en-keyword=integrin
kn-keyword=integrin
en-keyword=cancer microenvironment
kn-keyword=cancer microenvironment
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=1142886
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230223
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: EMT has been proposed to be a crucial early event in cancer metastasis. EMT is rigidly regulated by the action of several EMT-core transcription factors, particularly ZEB1. We previously revealed an unusual role of ZEB1 in the S100A8/A9-mediated metastasis in breast cancer cells that expressed ZEB1 at a significant level and showed that the ZEB1 was activated on the MCAM-downstream pathway upon S100A8/A9 binding. ZEB1 is well known to require Zn2+ for its activation based on the presence of several Zn-finger motifs in the transcription factor. However, how Zn2+-binding works on the pleiotropic role of ZEB1 through cancer progression has not been fully elucidated. <br>
Methods: We established the engineered cells, MDA-MB-231 MutZEB1 (MDA-MutZEB1), that stably express MutZEB1 (Delta Zn). The cells were then evaluated in vitro for their invasion activities. Finally, an RNA-Seq analysis was performed to compare the gene alteration profiles of the established cells comprehensively. <br>
Results: MDA-MutZEB1 showed a significant loss of the EMT, ultimately stalling the invasion. Inclusive analysis of the transcription changes after the expression of MutZEB1 (Delta Zn) in MDA-MB-231 cells revealed the significant downregulation of LOX family genes, which are known to play a critical role in cancer metastasis. We found that LOXL1 and LOXL4 remarkably enhanced cancer invasiveness among the LOX family genes with altered expression. <br>
Conclusions: These findings indicate that ZEB1 potentiates Zn2+-mediated transcription of plural EMT-relevant factors, including LOXL1 and LOXL4, whose upregulation plays a critical role in the invasive dissemination of breast cancer cells.
en-copyright=
kn-copyright=

en-aut-name=HirabayashiDaisuke
en-aut-sei=Hirabayashi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MaruyamaAkihiro
en-aut-sei=Maruyama
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KomalasariNi Luh Gede Yoni
en-aut-sei=Komalasari
en-aut-mei=Ni Luh Gede Yoni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=GoharaYuma
en-aut-sei=Gohara
en-aut-mei=Yuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=ZhouJin
en-aut-sei=Zhou
en-aut-mei=Jin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=RumaI. Made Winarsa
en-aut-sei=Ruma
en-aut-mei=I. Made Winarsa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SumardikaI. Wayan
en-aut-sei=Sumardika
en-aut-mei=I. Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KuribayashiFutoshi
en-aut-sei=Kuribayashi
en-aut-mei=Futoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of General Surgery & Bio-Bank of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Medical Oncology Department of Gastrointestinal Tumors, Liaoning Cancer Hospital & Institute, Cancer Hospital of the Dalian University of Technology
kn-affil=

affil-num=12
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=13
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=14
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=15
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=16
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=17
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=18
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=epithelial-to-mesenchymal transition
kn-keyword=epithelial-to-mesenchymal transition
en-keyword=triple-negative breast cancer
kn-keyword=triple-negative breast cancer
en-keyword=zinc
kn-keyword=zinc
en-keyword=ZEB1
kn-keyword=ZEB1
en-keyword=metastasis
kn-keyword=metastasis
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=1
article-no=
start-page=822
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230103
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cycloartenyl Ferulate Is the Predominant Compound in Brown Rice Conferring Cytoprotective Potential against Oxidative Stress-Induced Cytotoxicity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Since brown rice extract is a rich source of biologically active compounds, the present study is aimed to quantify the major compounds in brown rice and to compare their cytoprotective potential against oxidative stress. The content of the main hydrophobic compounds in brown rice followed the order of cycloartenyl ferulate (CAF) (89.00 +/- 8.07 nmol/g) >> alpha-tocopherol (alpha T) (19.73 +/- 2.28 nmol/g) > gamma-tocotrienol (gamma T3) (18.24 +/- 1.41 nmol/g) > alpha-tocotrienol (alpha T3) (16.02 +/- 1.29 nmol/g) > gamma-tocopherol (gamma T) (3.81 +/- 0.40 nmol/g). However, the percent contribution of CAF to the radical scavenging activity of one gram of whole brown rice was similar to those of alpha T, alpha T3, and gamma T3 because of its weaker antioxidant activity. The CAF pretreatment displayed a significant cytoprotective effect on the hydrogen peroxide-induced cytotoxicity from 10 mu M, which is lower than the minimal concentrations of alpha T and gamma T required for a significant protection. CAF also enhanced the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation coincided with the enhancement of the heme oxygenase-1 (HO-1) mRNA level. An HO-1 inhibitor, tin protoporphyrin IX (SnPP), significantly impaired the cytoprotection of CAF. The cytoprotective potential of CAF is attributable to its cycloartenyl moiety besides the ferulyl moiety. These results suggested that CAF is the predominant cytoprotector in brown rice against hydrogen peroxide-induced cytotoxicity.
en-copyright=
kn-copyright=

en-aut-name=WuHongyan
en-aut-sei=Wu
en-aut-mei=Hongyan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraToshiyuki
en-aut-sei=Nakamura
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=GuoYingnan
en-aut-sei=Guo
en-aut-mei=Yingnan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsumotoRiho
en-aut-sei=Matsumoto
en-aut-mei=Riho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=School of Food Science and Technology, Dalian Polytechnic University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=School of Food Science and Technology, Dalian Polytechnic University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=cycloartenyl ferulate
kn-keyword=cycloartenyl ferulate
en-keyword=antioxidative effect
kn-keyword=antioxidative effect
en-keyword=cytoprotective potential
kn-keyword=cytoprotective potential
en-keyword=heme oxygenase-1
kn-keyword=heme oxygenase-1
en-keyword=nuclear factor erythroid 2-related factor 2
kn-keyword=nuclear factor erythroid 2-related factor 2
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=93854
end-page=93866
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=2022
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effectiveness of Tactile Warning and Voice Command for Enhancing Safety of Drivers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Safety is impaired when drivers are required to perform main driving task (tracking of own car, distance maintenance between own car and a leading car, and response to target objects) and secondary task simultaneously, for example, responding to target cars on the road while operating in-vehicle equipment. A two-factor (presence or absence of tactile warning by input modality (no secondary task, voice command for a secondary task, and manual input for a secondary task)) within-subject design of ten licensed males was used to investigate how to compensate for safety impairments (decreased performance of a main and a secondary task such as increased tracking error during driving or increased reaction time to target cars on the road). We investigated whether the use of tactile warnings transmitted via left and right thighs for detecting road objects and voice command to operate in-vehicle equipment could compensate for safety impairments such as the increased reaction time to target cars on the road, the increase of detection error of target cars, or increased tracking error in driving. The accuracy and speed of responses to target cars encountered during driving were reduced when a driver was asked to perform the main and the secondary task simultaneously compared to situations performing only the main driving task (tracking, distance maintenance, and response to target cars). The availability of a tactile warning system for road objects compensated for these diminished performance measures, including slower response times and the increased detection error of target cars. Likewise, voice command contributed to enhanced performance of the main driving task such as decrease of tracking error.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DoiToshihisa
en-aut-sei=Doi
en-aut-mei=Toshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KarwowskiWaldemar
en-aut-sei=Karwowski
en-aut-mei=Waldemar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name= (Life Senior Member, IEEE)
en-aut-sei= (Life Senior Member, IEEE)
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Living Environment Design, Graduate School of Human Life and Ecology, Osaka Metropolitan University
kn-affil=

affil-num=3
en-affil=Engineering and Management Systems, University of Central Florida
kn-affil=

affil-num=4
en-affil=
kn-affil=
en-keyword=Haptic interfaces
kn-keyword=Haptic interfaces
en-keyword=Interference
kn-keyword=Interference
en-keyword=Visualization
kn-keyword=Visualization
en-keyword=Graphical user interfaces
kn-keyword=Graphical user interfaces
en-keyword=Target tracking
kn-keyword=Target tracking
en-keyword=Intelligent vehicles
kn-keyword=Intelligent vehicles
en-keyword=Vehicle safety
kn-keyword=Vehicle safety
en-keyword=Speech recognition
kn-keyword=Speech recognition
en-keyword=Automotive safety
kn-keyword=Automotive safety
en-keyword=interference of multiple tasks
kn-keyword=interference of multiple tasks
en-keyword=tactile warning
kn-keyword=tactile warning
en-keyword=voice command
kn-keyword=voice command
END

start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=18
article-no=
start-page=10300
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220907
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The dissection of the complex multistep process of metastasis exposes vulnerabilities that could be exploited to prevent metastasis. To search for possible factors that favor metastatic outgrowth, we have been focusing on secretory S100A8/A9. A heterodimer complex of the S100A8 and S100A9 proteins, S100A8/A9 functions as a strong chemoattractant, growth factor, and immune suppressor, both promoting the cancer milieu at the cancer-onset site and cultivating remote, premetastatic cancer sites. We previously reported that melanoma cells show lung-tropic metastasis owing to the abundant expression of S100A8/A9 in the lung. In the present study, we addressed the question of why melanoma cells are not metastasized into the brain at significant levels in mice despite the marked induction of S100A8/A9 in the brain. We discovered the presence of plasma histidine-rich glycoprotein (HRG), a brain-metastasis suppression factor against S100A8/A9. Using S100A8/A9 as an affinity ligand, we searched for and purified the binding plasma proteins of S100A8/A9 and identified HRG as the major protein on mass spectrometric analysis. HRG prevents the binding of S100A8/A9 to the B16-BL6 melanoma cell surface via the formation of the S100A8/A9 complex. HRG also inhibited the S100A8/A9-induced migration and invasion of A375 melanoma cells. When we knocked down HRG in mice bearing skin melanoma, metastasis to both the brain and lungs was significantly enhanced. The clinical examination of plasma S100A8/A9 and HRG levels showed that lung cancer patients with brain metastasis had higher S100A8/A9 and lower HRG levels than nonmetastatic patients. These results suggest that the plasma protein HRG strongly protects the brain and lungs from the threat of melanoma metastasis.
en-copyright=
kn-copyright=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WakeHidenori
en-aut-sei=Wake
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=RumaI. Made Winarsa
en-aut-sei=Ruma
en-aut-mei=I. Made Winarsa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SuzawaKen
en-aut-sei=Suzawa
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=GoharaYuma
en-aut-sei=Gohara
en-aut-mei=Yuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KomalasariNi Luh Gede Yoni
en-aut-sei=Komalasari
en-aut-mei=Ni Luh Gede Yoni
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=YamamotoKen-Ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SumardikaI. Wayan
en-aut-sei=Sumardika
en-aut-mei=I. Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=FutamiJunichiro
en-aut-sei=Futami
en-aut-mei=Junichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=KuribayashiFutoshi
en-aut-sei=Kuribayashi
en-aut-mei=Futoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=KondoEisaku
en-aut-sei=Kondo
en-aut-mei=Eisaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=NishiboriMasahiro
en-aut-sei=Nishibori
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Pharmacology, Kindai University Faculty of Medicine
kn-affil=

affil-num=4
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=5
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=6
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Faculty of Medicine, Udayana University
kn-affil=

affil-num=13
en-affil=Department of General Surgery & Bio-Bank of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University
kn-affil=

affil-num=14
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=15
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=16
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=17
en-affil=Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=18
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=19
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=20
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=S100A8/A9
kn-keyword=S100A8/A9
en-keyword=HRG
kn-keyword=HRG
en-keyword=metastasis
kn-keyword=metastasis
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=70806
end-page=70814
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=2022
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sensitivity of PERCLOS70 to Drowsiness Level: Effectiveness of PERCLOS70 to Prevent Crashes Caused by Drowsiness
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=It has been reported that many crashes are caused by drowsiness. Thus, it is critical to predict the occurrence of severe drowsiness that may result in a crash by means of an effective measure. The aim of this study was to investigate whether percentage closure (PERCLOS) of 70% was useful for evaluating drowsiness level of individual drivers and preventing crashes caused by drowsy driving using a driving simulator system. The first experiment measured PERCLOS70 during both aroused and drowsy states in a driving simulator task and investigated how PERCLOS70 changes when a participant fell asleep. In the second experiment, we measured PERCLOS70 and investigated the relation between PERCLOS70 and Karolinska Sleepiness Scale (KSS) ratings during a simulated driving task. The aggregated mean PERCLOS70 was significantly higher when participants fell asleep than when they were aroused. This tendency was also observed for individual participants. The aggregated mean PERCLOS70 was found to be sensitive to changes in KSS scores and increased with increasing KSS score. Linear trend analysis revealed a significant increasing trend for PERCLOS70 as a function of the KSS rating. This tendency was also observed for individual participants. PERCLOS70 was found to be sensitive to the drowsiness level both for data aggregated across all participants and data for individual participants. The main findings of the two experiments reported herein suggest that PERCLOS70 can be used effectively to evaluate drowsiness of individual drivers and prevent crashes caused by drowsy driving.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DoiToshihisa
en-aut-sei=Doi
en-aut-mei=Toshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KarwowskiWaldemar
en-aut-sei=Karwowski
en-aut-mei=Waldemar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Engineering and Management Systems, University of Central Florida
kn-affil=
en-keyword=Computer crashes
kn-keyword=Computer crashes
en-keyword=Sensitivity
kn-keyword=Sensitivity
en-keyword=Particle measurements
kn-keyword=Particle measurements
en-keyword=Atmospheric measurements
kn-keyword=Atmospheric measurements
en-keyword=Eyelids
kn-keyword=Eyelids
en-keyword=Task analysis
kn-keyword=Task analysis
en-keyword=Data aggregation
kn-keyword=Data aggregation
en-keyword=Arousal level
kn-keyword=Arousal level
en-keyword=drowsiness
kn-keyword=drowsiness
en-keyword=PERCLOS70
kn-keyword=PERCLOS70
en-keyword=Karolinska sleepiness scale
kn-keyword=Karolinska sleepiness scale
en-keyword=trend analysis
kn-keyword=trend analysis
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=6
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211222
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Delayed Evacuation after a Disaster Because of Irrational Prediction of the Future Cumulative Precipitation Time Series under Asymmetry of Information
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigated biased prediction of cumulative precipitation, using a variety of patterns of histories of cumulative precipitation, to explore how such biased prediction could delay evacuation or evacuation orders. The irrationality in predicting the future of cumulative precipitation was examined to obtain insights into the causes of delayed evacuation or evacuation orders using a simulated prediction of future cumulative precipitation based on the cumulative precipitation history. Anchoring and adjustment, or availability bias stemming from asymmetry of information, was observed in the prediction of cumulative precipitation, and found to delay evacuation or evacuation orders.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DoiToshihisa
en-aut-sei=Doi
en-aut-mei=Toshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HasegawaRin
en-aut-sei=Hasegawa
en-aut-mei=Rin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KarwowskiWaldemar
en-aut-sei=Karwowski
en-aut-mei=Waldemar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Industrial Engineering and Management Systems, University of Central Florida
kn-affil=
en-keyword=flooding of riverbanks
kn-keyword=flooding of riverbanks
en-keyword=delayed evacuation
kn-keyword=delayed evacuation
en-keyword=cumulative precipitation
kn-keyword=cumulative precipitation
en-keyword=asymmetry of information
kn-keyword=asymmetry of information
en-keyword=prediction failure
kn-keyword=prediction failure
en-keyword=anchoring and adjustment
kn-keyword=anchoring and adjustment
en-keyword=availability bias
kn-keyword=availability bias
END

start-ver=1.4
cd-journal=joma
no-vol=23
cd-vols=
no-issue=3
article-no=
start-page=1762
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220203
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Major Intestinal Catabolite of Quercetin Glycosides, 3-Hydroxyphenylacetic Acid, Protects the Hepatocytes from the Acetaldehyde-Induced Cytotoxicity through the Enhancement of the Total Aldehyde Dehydrogenase Activity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aldehyde dehydrogenases (ALDHs) are the major enzyme superfamily for the aldehyde metabolism. Since the ALDH polymorphism leads to the accumulation of acetaldehyde, we considered that the enhancement of the liver ALDH activity by certain food ingredients could help prevent alcohol-induced chronic diseases. Here, we evaluated the modulating effects of 3-hydroxyphenylacetic acid (OPAC), the major metabolite of quercetin glycosides, on the ALDH activity and acetaldehyde-induced cytotoxicity in the cultured cell models. OPAC significantly enhanced the total ALDH activity not only in mouse hepatoma Hepa1c1c7 cells, but also in human hepatoma HepG2 cells. OPAC significantly increased not only the nuclear level of aryl hydrocarbon receptor (AhR), but also the AhR-dependent reporter gene expression, though not the nuclear factor erythroid-2-related factor 2 (Nrf2)-dependent one. The pretreatment of OPAC at the concentration required for the ALDH upregulation completely inhibited the acetaldehyde-induced cytotoxicity. Silencing AhR impaired the resistant effect of OPAC against acetaldehyde. These results strongly suggested that OPAC protects the cells from the acetaldehyde-induced cytotoxicity, mainly through the AhR-dependent and Nrf2-independent enhancement of the total ALDH activity. Our findings suggest that OPAC has a protective potential in hepatocyte models and could offer a new preventive possibility of quercetin glycosides for targeting alcohol-induced chronic diseases.
en-copyright=
kn-copyright=

en-aut-name=LiuYujia
en-aut-sei=Liu
en-aut-mei=Yujia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MyojinTakumi
en-aut-sei=Myojin
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=LiKexin
en-aut-sei=Li
en-aut-mei=Kexin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KuritaAyuki
en-aut-sei=Kurita
en-aut-mei=Ayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SetoMasayuki
en-aut-sei=Seto
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MotoyamaAyano
en-aut-sei=Motoyama
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=LiuXiaoyang
en-aut-sei=Liu
en-aut-mei=Xiaoyang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SatohAyano
en-aut-sei=Satoh
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NakamuraToshiyuki
en-aut-sei=Nakamura
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=School of Biological Engineering, Dalian Polytechnic University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=8
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=10
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=11
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=12
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=3-hydroxyphenylacetic acid
kn-keyword=3-hydroxyphenylacetic acid
en-keyword=aldehyde dehydrogenase
kn-keyword=aldehyde dehydrogenase
en-keyword=quercetin metabolites
kn-keyword=quercetin metabolites
en-keyword=aryl hydrocarbon receptor
kn-keyword=aryl hydrocarbon receptor
en-keyword=acetaldehyde
kn-keyword=acetaldehyde
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=11
article-no=
start-page=2111
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20211107
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Irrationality of Attitudes toward Safety under Complexity and Uncertainty Leading to Asymmetry of Information
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study investigated how complexity and uncertainty, the probability of accidents, and the probability of financial trouble affected individuals' recognition of validity of irrational risk-seeking decisions. As a result of conducting a multiple regression analysis on the validation score for irrational risk-seeking alternative obtained by a questionnaire survey, we found that the validity score for an irrational risk-seeking alternative was higher when both complexity and uncertainty were high than when both complexity and uncertainty were low, which means that high complexity and high uncertainty in the situation of decision making more readily leads to an irrational risk-seeking behavior that might trigger a major accident. Beyond complexity and uncertainty, the damage of major accident alpha, the decrease of the probability of major accidents and the increase of the probability of financial trouble (economic factor) were also found to promote the choice of irrational risk-seeking alternatives. Some implications for safety management under high complexity and uncertainty are discussed.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YoshidaSyusuke
en-aut-sei=Yoshida
en-aut-mei=Syusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=DoiToshihisa
en-aut-sei=Doi
en-aut-mei=Toshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KarwowskiWaldemar
en-aut-sei=Karwowski
en-aut-mei=Waldemar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Industrial Engineering and Management Systems, University of Central Florida
kn-affil=
en-keyword=complexity
kn-keyword=complexity
en-keyword=uncertainty
kn-keyword=uncertainty
en-keyword=asymmetry of information
kn-keyword=asymmetry of information
en-keyword=probability of accidents
kn-keyword=probability of accidents
en-keyword=probability of financial trouble
kn-keyword=probability of financial trouble
en-keyword=cognitive bias
kn-keyword=cognitive bias
en-keyword=risk-seeking
kn-keyword=risk-seeking
END

start-ver=1.4
cd-journal=joma
no-vol=22
cd-vols=
no-issue=13
article-no=
start-page=7235
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210705
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Citric Acid-Mediated Abiotic Stress Tolerance in Plants
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Several recent studies have shown that citric acid/citrate (CA) can confer abiotic stress tolerance to plants. Exogenous CA application leads to improved growth and yield in crop plants under various abiotic stress conditions. Improved physiological outcomes are associated with higher photosynthetic rates, reduced reactive oxygen species, and better osmoregulation. Application of CA also induces antioxidant defense systems, promotes increased chlorophyll content, and affects secondary metabolism to limit plant growth restrictions under stress. In particular, CA has a major impact on relieving heavy metal stress by promoting precipitation, chelation, and sequestration of metal ions. This review summarizes the mechanisms that mediate CA-regulated changes in plants, primarily CA's involvement in the control of physiological and molecular processes in plants under abiotic stress conditions. We also review genetic engineering strategies for CA-mediated abiotic stress tolerance. Finally, we propose a model to explain how CA's position in complex metabolic networks involving the biosynthesis of phytohormones, amino acids, signaling molecules, and other secondary metabolites could explain some of its abiotic stress-ameliorating properties. This review summarizes our current understanding of CA-mediated abiotic stress tolerance and highlights areas where additional research is needed.
en-copyright=
kn-copyright=

en-aut-name=Tahjib-Ul-ArifMd.
en-aut-sei=Tahjib-Ul-Arif
en-aut-mei=Md.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ZahanMst, Ishrat
en-aut-sei=Zahan
en-aut-mei=Mst, Ishrat
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KarimMd. Masudul
en-aut-sei=Karim
en-aut-mei=Md. Masudul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ImranShahin
en-aut-sei=Imran
en-aut-mei=Shahin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HunterCharles T.
en-aut-sei=Hunter
en-aut-mei=Charles T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IslamMd. Saiful
en-aut-sei=Islam
en-aut-mei=Md. Saiful
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiaMd. Ashik
en-aut-sei=Mia
en-aut-mei=Md. Ashik
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HannanMd. Abdul
en-aut-sei=Hannan
en-aut-mei=Md. Abdul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=RhamanMohammad Saidur
en-aut-sei=Rhaman
en-aut-mei=Mohammad Saidur
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HossainMd. Afzal
en-aut-sei=Hossain
en-aut-mei=Md. Afzal
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=BresticMarian
en-aut-sei=Brestic
en-aut-mei=Marian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SkalickyMilan
en-aut-sei=Skalicky
en-aut-mei=Milan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Plant Breeding Division, Bangladesh Rice Research Institute
kn-affil=

affil-num=3
en-affil=Department of Crop Botany, Bangladesh Agricultural University
kn-affil=

affil-num=4
en-affil=Department of Agronomy, Khulna Agricultural University
kn-affil=

affil-num=5
en-affil=Chemistry Research Unit, United States Department of Agriculture—Agricultural Research Service
kn-affil=

affil-num=6
en-affil=Department of Fisheries, Bangamata Sheikh Fojilatunnesa Mujib Science and Technology University
kn-affil=

affil-num=7
en-affil=Department of Crop Botany, Bangladesh Agricultural University
kn-affil=

affil-num=8
en-affil=Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University
kn-affil=

affil-num=9
en-affil=Department of Seed Science and Technology, Bangladesh Agricultural University
kn-affil=

affil-num=10
en-affil=Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University
kn-affil=

affil-num=11
en-affil=Department of Plant Physiology, Slovak University of Agriculture
kn-affil=

affil-num=12
en-affil=Department of Botany and Plant Physiology, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague
kn-affil=

affil-num=13
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=citrate
kn-keyword=citrate
en-keyword=heavy metal stress
kn-keyword=heavy metal stress
en-keyword=drought stress
kn-keyword=drought stress
en-keyword=antioxidant
kn-keyword=antioxidant
en-keyword=reactive oxygen species
kn-keyword=reactive oxygen species
en-keyword=salinity
kn-keyword=salinity
en-keyword=aluminum toxicity
kn-keyword=aluminum toxicity
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=5
article-no=
start-page=803
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210505
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Asymmetry of Authority or Information Underlying Insufficient Communication Associated with a Risk of Crashes or Incidents in Passenger Railway Transportation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Similar crashes or incidents may recur as a result of insufficient communication in uncertain and risky situations that potentially threaten safety. The common root causes of insufficient communication across a series of incidents and crashes must be explored in detail to prevent a vicious circle of similar incidents or crashes from occurring. This study summarizes a series of incidents and crashes (derailment due to excessive train speed) at JR West at the West Japan Railway Company (JR West) that are considered to have arisen from insufficient communication. The incidents included (i) resuming train service without confirming the number of passengers on board and leaving passengers behind the station at Higashi-Hiroshima station, (ii) continuing train service in spite of an apparent risk of a crash detected at Okayama station, and (iii) leaving the crack of the train hood as it was at Kokura station. We discuss the causes of insufficient communication (particularly in relation to the sharing of information) among the three branches of staff-the station staff, the conductor and train driver, and the train operation management center-that led to the incidents or crashes. Two factors contributed to the insufficient communication in the series of incidents and crashes: (a) Asymmetry of authority, which hinders the discussion of issues openly and equally among the branches concerned. (b) An unacceptable level of knowledge or information for all branches concerned.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KarwowskiWaldemar
en-aut-sei=Karwowski
en-aut-mei=Waldemar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Industrial Engineering and Management Systems, University of Central Florida
kn-affil=
en-keyword=passenger railway transportation
kn-keyword=passenger railway transportation
en-keyword=crash
kn-keyword=crash
en-keyword=incident
kn-keyword=incident
en-keyword=insufficient communication
kn-keyword=insufficient communication
en-keyword=risk
kn-keyword=risk
en-keyword=asymmetry of authority
kn-keyword=asymmetry of authority
END

start-ver=1.4
cd-journal=joma
no-vol=970
cd-vols=
no-issue=
article-no=
start-page=609
end-page=620
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201967
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cross-Cultural Analysis of Top Page Design Among Brazilian, Chinese, Japanese and United States Web Sites
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of present study was to reveal the differences of web design including cultural preference among the four countries that have different cultures. Twenty local municipal sites were randomly chosen from United States, Japan, China, and Brazil. The characteristics of these web sites was investigated from viewpoint of the following seven categories: (1) text, (2) layout, (3) navigation, (4) multimedia, (5) links, (6) items location, (7) color. When the web site had each factor, the researcher gave a "1" for that factor. Chi-square goodness-of-fit test was performed to compare the percentage of "0" or "1" of each factor among the four countries. Additionally, the correspondence analysis was performed to grasp the characteristics of each country. The characteristics of the top page design of the four countries were grasped based on these analyses.
en-copyright=
kn-copyright=

en-aut-name=DoiToshihisa
en-aut-sei=Doi
en-aut-mei=Toshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
en-keyword=Web design
kn-keyword=Web design
en-keyword=Cultural difference
kn-keyword=Cultural difference
en-keyword=Appearance
kn-keyword=Appearance
en-keyword=Cultural usability
kn-keyword=Cultural usability
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=
article-no=
start-page=27
end-page=34
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200327
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Trends in research on sarcopenia in Japan
kn-title=日本におけるサルコペニアに関する研究の動向
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkazakiMizuki
en-aut-sei=Okazaki
en-aut-mei=Mizuki
kn-aut-name=岡崎瑞生
kn-aut-sei=岡崎
kn-aut-mei=瑞生
aut-affil-num=1
ORCID=

en-aut-name=MurataKohji
en-aut-sei=Murata
en-aut-mei=Kohji
kn-aut-name=村田幸治
kn-aut-sei=村田
kn-aut-mei=幸治
aut-affil-num=2
ORCID=

affil-num=1
en-affil=School of Human Nursing, The University Of Shiga Prefecture
kn-affil=滋賀県立大学人間看護学部

affil-num=2
en-affil=Graduate School of Nursing, Sanyo Gakuen University
kn-affil=山陽学園大学大学院看護学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=22688
end-page=22697
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210129
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of an Eye-Gaze Input System With High Speed and Accuracy through Target Prediction Based on Homing Eye Movements
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this study, a method to predict a target on the basis of the trajectory of eye movements and to increase the pointing speed while maintaining high predictive accuracy is proposed. First, a predictive method based on ballistic (fast) eye movements (Approach 1) was evaluated in terms of pointing speed and predictive accuracy. In Approach 1, the so-called Midas touch problem (pointing to an unintended target) occurred, particularly when a small number of samples was used to predict a target. Therefore, to overcome the poor predictive accuracy of Approach 1, we developed a new predictive method (Approach 2) using homing (slow) eye movements rather than ballistic (fast) eye movements. Approach 2 overcame the disadvantage (inaccurate prediction) of Approach 1 by shortening the pointing time while maintaining high predictive accuracy.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DoiToshihisa
en-aut-sei=Doi
en-aut-mei=Toshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KageyamaKazushi
en-aut-sei=Kageyama
en-aut-mei=Kazushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KarwowskiWaldemar
en-aut-sei=Karwowski
en-aut-mei=Waldemar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Intelligent Mechanical Systems, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Engineering and Management Systems, University of Central Florida
kn-affil=
en-keyword=Eye-gaze input
kn-keyword=Eye-gaze input
en-keyword=target predictive method
kn-keyword=target predictive method
en-keyword=ballistic eye movement
kn-keyword=ballistic eye movement
en-keyword=homing eye movement
kn-keyword=homing eye movement
en-keyword=pointing time
kn-keyword=pointing time
en-keyword=predictive accuracy
kn-keyword=predictive accuracy
en-keyword=Midas touch
kn-keyword=Midas touch
END

start-ver=1.4
cd-journal=joma
no-vol=22
cd-vols=
no-issue=
article-no=
start-page=100768
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=202007
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense (SLC22A18AS) plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Our recent study revealed an important role of the neuroplastin (NPTN)β downstream signal in lung cancer dissemination in the lung. The molecular mechanism of the signal pathway downstream of NPTNβ is a serial activation of the key molecules we identified: tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) adaptor, nuclear factor (NF)IA/NFIB heterodimer transcription factor, and SAM pointed-domain containing ETS transcription factor (SPDEF). The question of how dissemination is controlled by SPDEF under the activated NPTNβ has not been answered. Here, we show that the NPTNβ-SPDEF-mediated induction of solute carrier family 22 member 18 antisense (SLC22A18AS) is definitely required for the epithelial-mesenchymal transition (EMT) through the NPTNβ pathway in lung cancer cells. In vitro, the induced EMT is linked to the acquisition of active cellular motility but not growth, and this is correlated with highly disseminative tumor progression in vivo. The publicly available data also show the poor survival of SLC22A18AS-overexpressing lung cancer patients. Taken together, these data highlight a crucial role of SLC22A18AS in lung cancer dissemination, which provides novel input of this molecule to the signal cascade of NPTNβ. Our findings contribute to a better understanding of NPTNβ-mediated lung cancer metastasis.
en-copyright=
kn-copyright=

en-aut-name=BajkowskaKarolina
en-aut-sei=Bajkowska
en-aut-mei=Karolina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SumardikaI. Wayan
en-aut-sei=Sumardika
en-aut-mei=I. Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=Gede Yoni KomalasariNi Luh
en-aut-sei=Gede Yoni Komalasari
en-aut-mei=Ni Luh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=JiangFan
en-aut-sei=Jiang
en-aut-mei=Fan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=Winarsa RumaI. Made
en-aut-sei=Winarsa Ruma
en-aut-mei=I. Made
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=Kasano-CamonesCarlos Ichiro
en-aut-sei=Kasano-Camones
en-aut-mei=Carlos Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=11
en-affil=University of Surrey
kn-affil=

affil-num=12
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=13
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=14
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Lung cancer
kn-keyword=Lung cancer
en-keyword=Metastasis
kn-keyword=Metastasis
en-keyword=Epithelial-mesenchymal transition
kn-keyword=Epithelial-mesenchymal transition
en-keyword=Solute carrier family 22 member 18 antisense
kn-keyword=Solute carrier family 22 member 18 antisense
en-keyword=S100A8/A9
kn-keyword=S100A8/A9
en-keyword=Neuroplastin
kn-keyword=Neuroplastin
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=10
article-no=
start-page=2922
end-page=2932
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibition of light-induced stomatal opening by allyl isothiocyanate does not require guard cell cytosolic Ca2+ signaling
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The glucosinolate-myrosinase system is a well-known defense system that has been shown to induce stomatal closure in Brassicales. Isothiocyanates are highly reactive hydrolysates of glucosinolates, and an isothiocyanate, allyl isothiocyanate (AITC), induces stomatal closure accompanied by elevation of free cytosolic Ca2+ concentration ([Ca2+](cyt)) in Arabidopsis. It remains unknown whether AITC inhibits light-induced stomatal opening. This study investigated the role of Ca2+ in AITC-induced stomatal closure and inhibition of light-induced stomatal opening. AITC induced stomatal closure and inhibited light-induced stomatal opening in a dose-dependent manner. A Ca2+ channel inhibitor, La3+, a Ca(2+)chelator, EGTA, and an inhibitor of Ca2+ release from internal stores, nicotinamide, inhibited AITC-induced [Ca2+](cyt) elevation and stomatal closure, but did not affect inhibition of light-induced stomatal opening. AITC activated non-selective Ca2+-permeable cation channels and inhibited inward-rectifying K+ (K-in(+)) channels in a Ca2+-independent manner. AITC also inhibited stomatal opening induced by fusicoccin, a plasma membrane H+-ATPase activator, but had no significant effect on fusicoccin-induced phosphorylation of the penultimate threonine of H+-ATPase. Taken together, these results suggest that AITC induces Ca2+ influx and Ca2+ release to elevate [Ca2+](cyt), which is essential for AITC-induced stomatal closure but not for inhibition of K-in(+) channels and light-induced stomatal opening.
en-copyright=
kn-copyright=

en-aut-name=YeWenxiu
en-aut-sei=Ye
en-aut-mei=Wenxiu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AndoEigo
en-aut-sei=Ando
en-aut-mei=Eigo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=RhamanMohammad Saidur
en-aut-sei=Rhaman
en-aut-mei=Mohammad Saidur
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=Tahjib-Ul-ArifMd
en-aut-sei=Tahjib-Ul-Arif
en-aut-mei=Md
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OkumaEiji
en-aut-sei=Okuma
en-aut-mei=Eiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KinoshitaToshinori
en-aut-sei=Kinoshita
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Science, Nagoya University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil=Institute of Transformative Bio-Molecule, Nagoya University
kn-affil=

affil-num=8
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Allyl isothiocyanate
kn-keyword=Allyl isothiocyanate
en-keyword=Arabidopsis
kn-keyword=Arabidopsis
en-keyword=calcium channel
kn-keyword=calcium channel
en-keyword=potassium channel
kn-keyword=potassium channel
en-keyword=proton pump
kn-keyword=proton pump
en-keyword=stomatal closure
kn-keyword=stomatal closure
en-keyword=stomatal opening
kn-keyword=stomatal opening
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=
dt-pub=
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Thlaspi arvense L.
kn-title=グンバイナズナ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
en-keyword=アブラナ科 (Brassicaceae)
kn-keyword=アブラナ科 (Brassicaceae)
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=10
article-no=
start-page=223
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191013
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Differential Response of Sugar Beet to Long-Term Mild to Severe Salinity in a Soil-Pot Culture
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Attempts to cultivate sugar beet (Beta vulgaris spp. vulgaris) in the sub-tropical saline soils are ongoing because of its excellent tolerance to salinity. However, the intrinsic adaptive physiology has not been discovered yet in the sub-tropical climatic conditions. In this study, we investigated morpho-physiological attributes, biochemical responses, and yield of sugar beet under a gradient of salinity in the soil-pot culture system to evaluate its adaptive mechanisms. Results exhibited that low and high salinity displayed a differential impact on growth, photosynthesis, and yield. Low to moderate salt stress (75 and 100 mM NaCl) showed no inhibition on growth and photosynthetic attributes. Accordingly, low salinity displayed simulative effect on chlorophyll and antioxidant enzymes activity which contributed to maintaining a balanced H2O2 accumulation and lipid peroxidation. Furthermore, relative water and proline content showed no alteration in low salinity. These factors contributed to improving the yield (tuber weight). On the contrary, 250 mM salinity showed a mostly inhibitory role on growth, photosynthesis, and yield. Collectively, our findings provide insights into the mild-moderate salt adaptation strategy in the soil culture test attributed to increased water content, elevation of photosynthetic pigment, better photosynthesis, and better management of oxidative stress. Therefore, cultivation of sugar beet in moderately saline-affected soils will ensure efficient utilization of lands.
en-copyright=
kn-copyright=

en-aut-name=Tahjib-UI-ArifMd.
en-aut-sei=Tahjib-UI-Arif
en-aut-mei=Md.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SohagAbdullah Al Mamun
en-aut-sei=Sohag
en-aut-mei=Abdullah Al Mamun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AfrinSonya
en-aut-sei=Afrin
en-aut-mei=Sonya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=BasharKazi Khayrul
en-aut-sei=Bashar
en-aut-mei=Kazi Khayrul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AfrinTania
en-aut-sei=Afrin
en-aut-mei=Tania
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MahamudA. G. M. Sofi Uddin
en-aut-sei=Mahamud
en-aut-mei=A. G. M. Sofi Uddin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=PolashMohammed Arif Sadik
en-aut-sei=Polash
en-aut-mei=Mohammed Arif Sadik
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HossainMd. Tahmeed
en-aut-sei=Hossain
en-aut-mei=Md. Tahmeed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SohelMd. Abu Taher
en-aut-sei=Sohel
en-aut-mei=Md. Abu Taher
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=BresticMarian
en-aut-sei=Brestic
en-aut-mei=Marian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Bangladesh Jute Research Institute
kn-affil=

affil-num=5
en-affil=Graduate Training Institute, Bangladesh Agricultural University
kn-affil=

affil-num=6
en-affil=Food Biochemistry Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=7
en-affil=Department of Crop Botany, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=8
en-affil=Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=9
en-affil=Agronomy and Farming System Division, Bangladesh Sugar Crop Research Institute
kn-affil=

affil-num=10
en-affil=Department of Plant Physiology, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture
kn-affil=

affil-num=11
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=antioxidant enzymes
kn-keyword=antioxidant enzymes
en-keyword=photosynthesis
kn-keyword=photosynthesis
en-keyword=reactive oxygen species
kn-keyword=reactive oxygen species
en-keyword=salinity
kn-keyword=salinity
en-keyword=sugar beet
kn-keyword=sugar beet
en-keyword=yield
kn-keyword=yield
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=8866
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019620
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Benzyl isothiocyanate (BITC) is a naturally-occurring isothiocyanate derived from cruciferous vegetables. BITC has been reported to inhibit the proliferation of various cancer cells, which is believed to be important for the inhibition of tumorigenesis. However, the detailed mechanisms of action remain unclear. In this study, we employed a budding yeast Saccharomyces cerevisiae as a model organism for screening. Twelve genes including MTW1 were identified as the overexpression suppressors for the antiproliferative effect of BITC using the genome-wide multi-copy plasmid collection for S. cerevisiae. Overexpression of the kinetochore protein Mtw1 counteracts the antiproliferative effect of BITC in yeast. The inhibitory effect of BITC on the proliferation of human colon cancer HCT-116 cells was consistently suppressed by the overexpression of Mis12, a human orthologue of Mtw1, and enhanced by the knockdown of Mis12. We also found that BITC increased the phosphorylated and ubiquitinated Mis12 level with consequent reduction of Mis12, suggesting that BITC degrades Mis12 through an ubiquitin-proteasome system. Furthermore, cell cycle analysis showed that the change in the Mis12 level affected the cell cycle distribution and the sensitivity to the BITC-induced apoptosis. These results provide evidence that BITC suppresses cell proliferation through the post-transcriptional regulation of the kinetochore protein Mis12.
en-copyright=
kn-copyright=

en-aut-name=Abe-KanohNaomi
en-aut-sei=Abe-Kanoh
en-aut-mei=Naomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KunisueNarumi
en-aut-sei=Kunisue
en-aut-mei=Narumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MyojinTakumi
en-aut-sei=Myojin
en-aut-mei=Takumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ChinoAyako
en-aut-sei=Chino
en-aut-mei=Ayako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SatohAyano
en-aut-sei=Satoh
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MoriyaHisao
en-aut-sei=Moriya
en-aut-mei=Hisao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=7
en-affil= Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=8
en-affil=Research Core for Interdisciplinary Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Environmental and Life Science, Okayama University, Okayama
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=2
article-no=
start-page=437
end-page=447
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180716
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The mechanism of SO2 -induced stomatal closure differs from O3 and CO2 responses and is mediated by nonapoptotic cell death in guard cells.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Plants closing stomata in the presence of harmful gases is believed to be a stress avoidance mechanism. SO2 , one of the major airborne pollutants, has long been reported to induce stomatal closure, yet the mechanism remains unknown. Little is known about the stomatal response to airborne pollutants besides O3 . SLOW ANION CHANNEL-ASSOCIATED 1 (SLAC1) and OPEN STOMATA 1 (OST1) were identified as genes mediating O3 -induced closure. SLAC1 and OST1 are also known to mediate stomatal closure in response to CO2 , together with RESPIRATORY BURST OXIDASE HOMOLOGs (RBOHs). The overlaying roles of these genes in response to O3 and CO2 suggested that plants share their molecular regulators for airborne stimuli. Here, we investigated and compared stomatal closure event induced by a wide concentration range of SO2 in Arabidopsis through molecular genetic approaches. O3 - and CO2 -insensitive stomata mutants did not show significant differences from the wild type in stomatal sensitivity, guard cell viability, and chlorophyll content revealing that SO2 -induced closure is not regulated by the same molecular mechanisms as for O3 and CO2 . Nonapoptotic cell death is shown as the reason for SO2 -induced closure, which proposed the closure as a physicochemical process resulted from SO2 distress, instead of a biological protection mechanism.
en-copyright=
kn-copyright=

en-aut-name=Ooi Lia
en-aut-sei=Ooi 
en-aut-mei=Lia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsuuraTakakazu
en-aut-sei=Matsuura
en-aut-mei=Takakazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KatsuharaMaki
en-aut-sei=Katsuhara
en-aut-mei=Maki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HirayamaTakashi
en-aut-sei=Hirayama
en-aut-mei=Takashi
kn-aut-name=平山隆志
kn-aut-sei=平山
kn-aut-mei=隆志
aut-affil-num=6
ORCID=

en-aut-name=MoriIzumi C.
en-aut-sei=Mori
en-aut-mei=Izumi C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil= Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil= Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil= Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=6
en-affil= Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=7
en-affil= Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=airborne pollutants
kn-keyword=airborne pollutants
en-keyword=nonapoptotic cell death
kn-keyword=nonapoptotic cell death
en-keyword=stomatal closure
kn-keyword=stomatal closure
en-keyword=sulfur dioxide
kn-keyword=sulfur dioxide
END

start-ver=1.4
cd-journal=joma
no-vol=18
cd-vols=
no-issue=
article-no=
start-page=100619
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201907
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Convenient methodology for extraction and subsequent selective propagation of mouse melanocytes in culture from adult mouse skin tissue
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Mouse melanoma B16-BL6 cells are useful cells for cancer metastatic studies. To understand the metastatic principle at molecular levels, it is necessary to carry out experiments in which cancer cells and their normal counterparts are compared. However, unlike normal human melanocytes, preparation of normal mouse melanocytes is quite difficult due to the lack of marketing and insufficient information on an established protocol for primary culture of mouse melanocytes. In this study, we aimed to establish a convenient method for primary culture of mouse melanocytes on the basis of the protocol for human melanocytes. The main obstacles to preparing pure mouse melanocytes are how to digest mouse skin tissue and how to reduce the contamination of keratinocytes and fibroblasts. The obstacles were overcome by collagenase digestion for skin specimens, short time trypsinization for separating melanocytes and keratinocytes, and use of 12-O-Tetradecanoylphorbol 13-acetate (TPA) and cholera toxin in the culture medium. These supplements act to prevent the proliferation of keratinocytes and fibroblasts, respectively. The convenient procedure enabled us to prepare a pure culture of normal mouse melanocytes. Using enriched normal mouse melanocytes and cancerous B16-BL6 cells, we compared the expression levels of melanoma cell adhesion molecule (MCAM), an important membrane protein for melanoma metastasis, in the cells. The results showed markedly higher expression of MCAM in B16-BL6 cells than in normal mouse melanocytes.
en-copyright=
kn-copyright=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SumardikaI. Wayan
en-aut-sei=Sumardika
en-aut-mei=I. Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University, Kiryu
kn-affil=

affil-num=6
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Melanocytes
kn-keyword=Melanocytes
en-keyword=Melanoma
kn-keyword=Melanoma
en-keyword=Metastasis
kn-keyword=Metastasis
en-keyword=Primary culture
kn-keyword=Primary culture
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=7
article-no=
start-page=627
end-page=640
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201907
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Metastatic breast cancer is the leading cause of cancer-associated death in women. The progression of this fatal disease is associated with inflammatory responses that promote cancer cell growth and dissemination, eventually leading to a reduction of overall survival. However, the mechanism(s) of the inflammation-boosted cancer progression remains unclear. In this study, we found for the first time that an extracellular cytokine, S100A8/A9, accelerates breast cancer growth and metastasis upon binding to a cell surface receptor, melanoma cell adhesion molecule (MCAM). Our molecular analyses revealed an important role of ETS translocation variant 4 (ETV4), which is significantly activated in the region downstream of MCAM upon S100A8/A9 stimulation, in breast cancer progression in vitro as well as in vivo. The MCAM-mediated activation of ETV4 induced a mobile phenotype called epithelial-mesenchymal transition (EMT) in cells, since we found that ETV4 transcriptionally upregulates ZEB1, a strong EMT inducer, at a very high level. In contrast, downregulation of either MCAM or ETV4 repressed EMT, resulting in greatly weakened tumor growth and lung metastasis. Overall, our results revealed that ETV4 is a novel transcription factor regulated by the S100A8/A9-MCAM axis, which leads to EMT through ZEB1 and thereby to metastasis in breast cancer cells. Thus, therapeutic strategies based on our findings might improve patient outcomes.
en-copyright=
kn-copyright=

en-aut-name=ChenYouyi
en-aut-sei=Chen
en-aut-mei=Youyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SumardikaI Wayan
en-aut-sei=Sumardika
en-aut-mei=I Wayan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TomonobuNahoko
en-aut-sei=Tomonobu
en-aut-mei=Nahoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IiokaHidekazu
en-aut-sei=Iioka
en-aut-mei=Hidekazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MitsuiYosuke
en-aut-sei=Mitsui
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SaitoKen
en-aut-sei=Saito
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=RumaI Made Winarsa
en-aut-sei=Ruma
en-aut-mei=I Made Winarsa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SatoHiroki
en-aut-sei=Sato
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=YamauchiAkira
en-aut-sei=Yamauchi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=TomidaShuta
en-aut-sei=Tomida
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=ShienKazuhiko
en-aut-sei=Shien
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=YamamotoHiromasa
en-aut-sei=Yamamoto
en-aut-mei=Hiromasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=SohJunichi
en-aut-sei=Soh
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=FutamiJunichiro
en-aut-sei=Futami
en-aut-mei=Junichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=KuboMiyoko
en-aut-sei=Kubo
en-aut-mei=Miyoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=PutrantoEndy Widya
en-aut-sei=Putranto
en-aut-mei=Endy Widya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=MurakamiTakashi
en-aut-sei=Murakami
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=LiuMing
en-aut-sei=Liu
en-aut-mei=Ming
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=HibinoToshihiko
en-aut-sei=Hibino
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

en-aut-name=NishiboriMasahiro
en-aut-sei=Nishibori
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=24
ORCID=

en-aut-name=KondoEisaku
en-aut-sei=Kondo
en-aut-mei=Eisaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=25
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=26
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=27
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=6
en-affil=Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=7
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Departments of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Biochemistry, Kawasaki Medical School
kn-affil=

affil-num=12
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Biobank, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=15
en-affil=Departments of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=16
en-affil=Departments of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=17
en-affil=Departments of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=18
en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=19
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=20
en-affil=Department of Pediatrics, Dr. Sardjito Hospital/Faculty of Medicine, Universitas Gadjah Mada
kn-affil=

affil-num=21
en-affil=Department of Microbiology, Faculty of Medicine, Saitama Medical University
kn-affil=

affil-num=22
en-affil=Department of General Surgery & Bio-Bank of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University
kn-affil=

affil-num=23
en-affil=Department of Dermatology, Tokyo Medical University
kn-affil=

affil-num=24
en-affil=Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=25
en-affil=Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences
kn-affil=

affil-num=26
en-affil=Departments of Thoracic, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=27
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=3-4
article-no=
start-page=688
end-page=635
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190319
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Le préjudice moral résultant de l’atteinte à la propriété
kn-title=所有権侵害の場合の精神的損害の賠償 (中富公一教授 高橋正徳准教授 吉岡伸一教授 退職記念号)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataK.
en-aut-sei=Murata
en-aut-mei=K.
kn-aut-name=村田健介
kn-aut-sei=村田
kn-aut-mei=健介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=67
cd-vols=
no-issue=2
article-no=
start-page=374
end-page=336
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Du droit à l’effacement des données à caractère personnel en cas d’atteinte à la vie privée et «le droit à l'oubli numérique», en analysant la décision du 31 janvier 2017 de la Cour Suprême du Japon
kn-title=プライヴァシー侵害による差止請求権と「忘れられる権利」 : 最決平29・１・31を踏まえて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataKensuke
en-aut-sei=Murata
en-aut-mei=Kensuke
kn-aut-name=村田健介
kn-aut-sei=村田
kn-aut-mei=健介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=8
article-no=
start-page=1779
end-page=1990
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Involvement of OST1 Protein Kinase and PYR/PYL/RCAR Receptors in Methyl Jasmonate-Induced Stomatal Closure in Arabidopsis Guard Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Methyl jasmonate (MeJA) induces stomatal closure. It has been shown that stomata of many ABA-insensitive mutants are also insensitive to MeJA, and a low amount of ABA is a prerequisite for the MeJA response. However, the molecular mechanisms of the interaction between ABA and MeJA signaling remain to be elucidated. Here we studied the interplay of signaling of the two hormones in guard cells using the quadruple ABA receptor mutant pyr1 pyl1 pyl2 pyl4 and ABA-activated protein kinase mutants ost1-2 and srk2e. In the quadruple mutant, MeJA-induced stomatal closure, H2O2 production, nitric oxide (NO) production, cytosolic alkalization and plasma membrane Ca(2+)-permeable current (ICa) activation were not impaired. At the same time, the inactivation of the inward-rectifying K(+) current was impaired. In contrast to the quadruple mutant, MeJA-induced stomatal closure, H2O2 production, NO production and cytosolic alkalization were impaired in ost1-2 and srk2e as well as in aba2-2, the ABA-deficient mutant. The activation of ICa was also impaired in srk2e. Collectively, these results indicated that OST1 was essential for MeJA-induced stomatal closure, while PYR1, PYL1, PYL2 and PYL4 ABA receptors were not sufficient factors. MeJA did not appear to activate OST1 kinase activity. This implies that OST1 mediates MeJA signaling through an undetectable level of activity or a non-enzymatic action. MeJA induced the expression of an ABA synthesis gene, NCED3, and increased ABA contents only modestly. Taken together with previous reports, this study suggests that MeJA signaling in guard cells is primed by ABA and is not brought about through the pathway mediated by PYR1, PYL1 PYL2 and PYL4.
en-copyright=
kn-copyright=

en-aut-name=YinYe
en-aut-sei=Yin
en-aut-mei=Ye
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AdachiYuji
en-aut-sei=Adachi
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraYoshimasa
en-aut-sei=Nakamura
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MunemasaShintaro
en-aut-sei=Munemasa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MoriIzumi C.
en-aut-sei=Mori
en-aut-mei=Izumi C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=ABA
kn-keyword=ABA
en-keyword=ABA receptors
kn-keyword=ABA receptors
en-keyword=Arabidopsis thaliana
kn-keyword=Arabidopsis thaliana
en-keyword=Guard cells
kn-keyword=Guard cells
en-keyword=Methyl jasmonate
kn-keyword=Methyl jasmonate
en-keyword=OST1 protein kinase
kn-keyword=OST1 protein kinase
END

start-ver=1.4
cd-journal=joma
no-vol=289
cd-vols=
no-issue=34
article-no=
start-page=23389
end-page=23402
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=201408
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The receptor for advanced glycation end products (RAGE) is involved in the pathogenesis of many inflammatory, degenerative, and hyperproliferative diseases, including cancer. Previously, we revealed mechanisms of downstream signaling from ligand-activated RAGE, which recruits TIRAP/MyD88. Here, we showed that DNAX-activating protein 10 (DAP10), a transmembrane adaptor protein, also binds to RAGE. By artificial oligomerization of RAGE alone or RAGE-DAP10, we found that RAGE-DAP10 heterodimer formation resulted in a marked enhancement of Akt activation, whereas homomultimeric interaction of RAGE led to activation of caspase 8. Normal human epidermal keratinocytes exposed to S100A8/A9, a ligand for RAGE, at a nanomolar concentration mimicked the pro-survival response of RAGE-DAP10 interaction, although at a micromolar concentration, the cells mimicked the pro-apoptotic response of RAGE-RAGE. In transformed epithelial cell lines, A431 and HaCaT, in which endogenous DAP10 was overexpressed, and S100A8/A9, even at a micromolar concentration, led to cell growth and survival due to RAGE-DAP10 interaction. Functional blocking of DAP10 in the cell lines abrogated the Akt phosphorylation from S100A8/A9-activated RAGE, eventually leading to an increase in apoptosis. Finally, S100A8/A9, RAGE, and DAP10 were overexpressed in the psoriatic epidermis. Our findings indicate that the functional interaction between RAGE and DAP10 coordinately regulates S100A8/A9-mediated survival and/or apoptotic response of keratinocytes.
en-copyright=
kn-copyright=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AoyamaYumi
en-aut-sei=Aoyama
en-aut-mei=Yumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HibinoToshihiko
en-aut-sei=Hibino
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=Widya PutrantoEndy
en-aut-sei=Widya Putranto
en-aut-mei=Endy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Winarsa Ruma I. Made
en-aut-sei=Winarsa Ruma
en-aut-mei= I. Made
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=InoueYusuke
en-aut-sei=Inoue
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SakaguchiYoshihiko
en-aut-sei=Sakaguchi
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamamotoKen-ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KinoshitaRie
en-aut-sei=Kinoshita
en-aut-mei=Rie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=FutamiJunichiro
en-aut-sei=Futami
en-aut-mei=Junichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KataokaKen
en-aut-sei=Kataoka
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IwatsukiKeiji
en-aut-sei=Iwatsuki
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=HuhNam-ho
en-aut-sei=Huh
en-aut-mei=Nam-ho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Shiseido Research Center, Advanced Science Research
kn-affil=

affil-num=5
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Faculty of Science and Technology, Division of Molecular Science, Gunma University
kn-affil=

affil-num=8
en-affil=Interdisciplinary Research Organization, University of Miyazaki
kn-affil=

affil-num=9
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Biotechnology, Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Biotechnology, Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Life Science, Faculty of Science, Okayama University of Science
kn-affil=

affil-num=13
en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Cancer
kn-keyword=Cancer
en-keyword=Cell Biology
kn-keyword=Cell Biology
en-keyword=Keratinocyte
kn-keyword=Keratinocyte
en-keyword=Psoriasis
kn-keyword=Psoriasis
en-keyword=Receptor for Advanced Glycation End Products (RAGE)
kn-keyword=Receptor for Advanced Glycation End Products (RAGE)
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=
article-no=
start-page=1
end-page=3
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Compulsory Repetitive Learning to Improve Student Achievement and Performance in Fundamental Subjects
kn-title=半強制的な反復学習による基礎科目の徹底教育
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　We employ the methodology of “Compulsory Repetitive Learning” to improve student learning and performance in fundamental subjects. It is a challenge for many universities to intrinsically motivate students and it is a demanding issue that a large part of students do not sufficiently do homework. Here, we let students solve the problems associated with the teaching immediately following each lecture. Through the usage of “Compulsory Repetitive Learning”, each student as well as the subject teacher(s) could monitor and evaluate the quality of student learning and performance.
en-copyright=
kn-copyright=

en-aut-name=IzumiMinoru
en-aut-sei=Izumi
en-aut-mei=Minoru
kn-aut-name=泉実
kn-aut-sei=泉
kn-aut-mei=実
aut-affil-num=1
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=村田芳行
kn-aut-sei=村田
kn-aut-mei=芳行
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=2
en-affil=Graduate School of Environmental and life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
en-keyword=compulsory repetitive learning
kn-keyword=compulsory repetitive learning
en-keyword=homework
kn-keyword=homework
en-keyword=exercises
kn-keyword=exercises
en-keyword=learning comprehension level
kn-keyword=learning comprehension level
END

start-ver=1.4
cd-journal=joma
no-vol=65
cd-vols=
no-issue=3・4
article-no=
start-page=792
end-page=830
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160318
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Le «droit à l'oubli», est-il nécessaire en droit japonais?
kn-title=「忘れられる権利」の位置付けに関する一考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataK.
en-aut-sei=Murata
en-aut-mei=K.
kn-aut-name=村田健介
kn-aut-sei=村田
kn-aut-mei=健介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=127
cd-vols=
no-issue=3
article-no=
start-page=219
end-page=222
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20151201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug-induced liver injury due to the long-term oral administration of rosuvastatin
kn-title=長期のロスバスタチンカルシウム服用にて発症したと考えられる薬物性肝障害の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 67-year-old man was admitted to our hospital presenting with a liver injury. He had used several types of oral medication for the prior 2 years, including rosuvastatin calcium for hypertension, hyperlipidemia, and prostatic hypertrophy. His liver dysfunction was noted for the first time in February 2013, and at re-examination in March 2013 he showed exacerbation of the liver dysfunction, he was admitted to our hospital at that time. We stopped all of his oral medications, and his liver function improved steadily. We conducted a drug-induced lymphocyte transformation test (DLST), and the rosuvastatin calcium result was positive. He was diagnosed as having a drug-induced (by rosvastatin calcium) liver injury. He resumed oral medications other than rosuvastatin calcium from the time of discharge, with no exacerbation of liver dysfunction since then. Reports of drug-induced liver injury due to drugs with a long-term oral administration are extremely rare. We discuss the relevant literature herein.
en-copyright=
kn-copyright=

en-aut-name=OonishiAyano
en-aut-sei=Oonishi
en-aut-mei=Ayano
kn-aut-name=大西理乃
kn-aut-sei=大西
kn-aut-mei=理乃
aut-affil-num=1
ORCID=

en-aut-name=KariyamaKazuya
en-aut-sei=Kariyama
en-aut-mei=Kazuya
kn-aut-name=狩山和也
kn-aut-sei=狩山
kn-aut-mei=和也
aut-affil-num=2
ORCID=

en-aut-name=WakutaAkiko
en-aut-sei=Wakuta
en-aut-mei=Akiko
kn-aut-name=湧田暁子
kn-aut-sei=湧田
kn-aut-mei=暁子
aut-affil-num=3
ORCID=

en-aut-name=NishimuraMamoru
en-aut-sei=Nishimura
en-aut-mei=Mamoru
kn-aut-name=西村守
kn-aut-sei=西村
kn-aut-mei=守
aut-affil-num=4
ORCID=

en-aut-name=NousoKazuhiro
en-aut-sei=Nouso
en-aut-mei=Kazuhiro
kn-aut-name=能祖一裕
kn-aut-sei=能祖
kn-aut-mei=一裕
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山市立市民病院

affil-num=2
en-affil=
kn-affil=岡山市立市民病院

affil-num=3
en-affil=
kn-affil=岡山市立市民病院

affil-num=4
en-affil=
kn-affil=岡山市立市民病院

affil-num=5
en-affil=
kn-affil=岡山市立市民病院
en-keyword=薬物性肝障害（drug induced liver injury）
kn-keyword=薬物性肝障害（drug induced liver injury）
en-keyword=ロスバスタチンカルシウム（Rosuvastatin）
kn-keyword=ロスバスタチンカルシウム（Rosuvastatin）
en-keyword=スタチン（statin）
kn-keyword=スタチン（statin）
en-keyword=DLST
kn-keyword=DLST
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20141120
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Benzyl isothiocyanate (BITC), a dietary isothiocyanate derived from cruciferous vegetables, inhibits the proliferation of colorectal cancer cells, most of which overexpress β-catenin as a result of mutations in the genes for adenomatous polyposis coli or mutations in β-catenin itself. Because nuclear factor-κB (NF-κB) is a plausible target of BITC signaling in inflammatory cell models, we hypothesized that it is also involved in BITC-inhibited proliferation of colorectal cancer cells. siRNA-mediated knockdown of the NF-κB p65 subunit significantly decreased the BITC sensitivity of human colorectal cancer HT-29 cells with mutated p53 tumor suppressor protein. Treating HT-29 cells with BITC induced the phosphorylation of IκB kinase, IκB-α and p65, the degradation of IκB-α, the translocation of p65 to the nucleus and the upregulation of NF-κB transcriptional activity. BITC also decreased β-catenin binding to a positive cis element of the cyclin D1 promoter and thus inhibited β-catenin-dependent cyclin D1 transcription, possibly through a direct interaction between p65 and β-catenin. siRNA-mediated knockdown of p65 confirmed that p65 negatively affects cyclin D1 expression. On the other hand, when human colorectal cancer HCT-116 cells with wild-type p53 were treated with BITC, translocation of p65 to the nucleus was inhibited rather than enhanced. p53 knockout increased the BITC sensitivity of HCT-116 cells in a p65-dependent manner, suggesting that p53 negatively regulates p65-dependent effects. Together, these results identify BITC as a novel type of antiproliferative agent that regulates the NF-κB pathway in p53-deficient colorectal cancer cells.
en-copyright=
kn-copyright=

en-aut-name=AbeN
en-aut-sei=Abe
en-aut-mei=N
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HouD-X
en-aut-sei=Hou
en-aut-mei=D-X
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MunemasaS
en-aut-sei=Munemasa
en-aut-mei=S
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurataY
en-aut-sei=Murata
en-aut-mei=Y
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakamuraY
en-aut-sei=Nakamura
en-aut-mei=Y
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Environmental and Life Science, Okayama University

affil-num=2
en-affil=
kn-affil=Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University

affil-num=3
en-affil=
kn-affil=Graduate School of Environmental and Life Science, Okayama University

affil-num=4
en-affil=
kn-affil=Graduate School of Environmental and Life Science, Okayama University

affil-num=5
en-affil=
kn-affil=Graduate School of Environmental and Life Science, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=2
article-no=
start-page=127
end-page=131
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars
kn-title=柿胃石の成分分析における標準物質としての柿渋の有用性
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The definite diagnosis of persimmon phytobezoar (i.e., diospyrobezoar) is often accomplished by a component analysis using infrared spectroscopy. However, no studies have been conducted to investigate which substance is the best as a standard for the component analysis. Here we analyzed tannic acid, Japanese persimmon (kaki), fermented persimmon extract (kaki-shibu), conventional dried persimmon, and dried persimmon smoked in sulfur (ampo-kaki) by infrared spectroscopy to determine which would be optimal as a component analysis standard. The spectrum between 1,600 to 600cm－1 of a persimmon phytobezoar was quite similar to the spectrum of kaki-shibu rather than that of tannic acid. Consequently, we conclude that kaki-shibu should be used as a standard for infrared spectroscopy analyses of persimmon phytobezoars.
en-copyright=
kn-copyright=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=岩室雅也
kn-aut-sei=岩室
kn-aut-mei=雅也
aut-affil-num=1
ORCID=

en-aut-name=OkamotoYuko
en-aut-sei=Okamoto
en-aut-mei=Yuko
kn-aut-name=岡本裕子
kn-aut-sei=岡本
kn-aut-mei=裕子
aut-affil-num=2
ORCID=

en-aut-name=MurataToshihiro
en-aut-sei=Murata
en-aut-mei=Toshihiro
kn-aut-name=村田年弘
kn-aut-sei=村田
kn-aut-mei=年弘
aut-affil-num=3
ORCID=

en-aut-name=KawaiYoshinari
en-aut-sei=Kawai
en-aut-mei=Yoshinari
kn-aut-name=河合良成
kn-aut-sei=河合
kn-aut-mei=良成
aut-affil-num=4
ORCID=

en-aut-name=ShirahaHidenori
en-aut-sei=Shiraha
en-aut-mei=Hidenori
kn-aut-name=白羽英則
kn-aut-sei=白羽
kn-aut-mei=英則
aut-affil-num=5
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=岡田裕之
kn-aut-sei=岡田
kn-aut-mei=裕之
aut-affil-num=6
ORCID=

en-aut-name=YamamotoKazuhide
en-aut-sei=Yamamoto
en-aut-mei=Kazuhide
kn-aut-name=山本和秀
kn-aut-sei=山本
kn-aut-mei=和秀
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学

affil-num=2
en-affil=
kn-affil=井原市立井原市民病院　内科

affil-num=3
en-affil=
kn-affil=尾道市立市民病院 外科

affil-num=4
en-affil=
kn-affil=尾道市立市民病院 消化器内科

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学

affil-num=6
en-affil=
kn-affil=岡山大学病院　光学医療診療部

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学
en-keyword=柿胃石（gastric phytobezoar）
kn-keyword=柿胃石（gastric phytobezoar）
en-keyword=タンニン酸（tannic acid）
kn-keyword=タンニン酸（tannic acid）
en-keyword=消化管異物（gastrointestinal foreign body）
kn-keyword=消化管異物（gastrointestinal foreign body）
en-keyword=成分分析（component analysis）
kn-keyword=成分分析（component analysis）
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=2
article-no=
start-page=83
end-page=86
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2013 Incentive Award of the Okayama Medical Association in General Medical Science (2013 Yuuki Prize)
kn-title=平成25年度岡山医学会賞 総合研究奨励賞（結城賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=村田等
kn-aut-sei=村田
kn-aut-mei=等
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　細胞生物学
END

start-ver=1.4
cd-journal=joma
no-vol=32
cd-vols=
no-issue=4
article-no=
start-page=938
end-page=944
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=201310
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Inhibition of RAGE signaling through the intracellular delivery of inhibitor peptides by PEI cationization
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The receptor for advanced glycation end products (RAGE) is a multi-ligand cell surface receptor and a member of the immunoglobulin superfamily. RAGE is involved in a wide range of inflammatory, degenerative and hyper-proliferative disorders which span over different organs by engaging diverse ligands, including advanced glycation end products, S100 family proteins, high-mobility group protein B1 (HMGB1) and amyloid beta. We previously demonstrated that the cytoplasmic domain of RAGE is phosphorylated upon the binding of ligands, enabling the recruitment of two distinct pairs of adaptor proteins, Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP) and myeloid differentiation protein 88 (MyD88). This engagement allows the activation of downstream effector molecules, and thereby mediates a wide variety of cellular processes, such as inflammatory responses, apoptotic cell death, migration and cell growth. Therefore, inhibition of the binding of TIRAP to RAGE may abrogate intracellular signaling from ligand-activated RAGE. In the present study, we developed inhibitor peptides for RAGE signaling (RAGE-I) by mimicking the phosphorylatable cytosolic domain of RAGE. RAGE-I was efficiently delivered into the cells by polyethylenimine (PEI) cationization. We demonstrated that RAGE-I specifically bound to TIRAP and abrogated the activation of Cdc42 induced by ligand-activated RAGE. Furthermore, we were able to reduce neuronal cell death induced by an excess amount of S100B and to inhibit the migration and invasion of glioma cells in vitro. Our results indicate that RAGE-I provides a powerful tool for therapeutics to block RAGE-mediated multiple signaling.
en-copyright=
kn-copyright=

en-aut-name=PutrantoEndy Widya
en-aut-sei=Putranto
en-aut-mei=Endy Widya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamamotoKen-Ichi
en-aut-sei=Yamamoto
en-aut-mei=Ken-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KataokaKen
en-aut-sei=Kataoka
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamadaHidenori
en-aut-sei=Yamada
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=FutamiJun-Ichiro
en-aut-sei=Futami
en-aut-mei=Jun-Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HuhNam-Ho
en-aut-sei=Huh
en-aut-mei=Nam-Ho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Biol

affil-num=2
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Biol

affil-num=3
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Biol

affil-num=4
en-affil=
kn-affil=Okayama Univ Sci, Fac Sci, Dept Life Sci

affil-num=5
en-affil=
kn-affil=Okayama Univ, Grad Sch Nat Sci & Biotechnol, Dept Med Bioengn Sci

affil-num=6
en-affil=
kn-affil=Okayama Univ, Grad Sch Nat Sci & Biotechnol, Dept Med Bioengn Sci

affil-num=7
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Biol

affil-num=8
en-affil=
kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Biol
en-keyword=receptor for advanced glycation end products
kn-keyword=receptor for advanced glycation end products
en-keyword=Toll-interleukin 1 receptor domain-containing adaptor protein
kn-keyword=Toll-interleukin 1 receptor domain-containing adaptor protein
en-keyword=cationization
kn-keyword=cationization
en-keyword=S100B
kn-keyword=S100B
en-keyword=cell death
kn-keyword=cell death
en-keyword=cell migration
kn-keyword=cell migration
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=1
article-no=
start-page=35
end-page=38
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of colon lipoma presenting with intussusception
kn-title=腸重積で発症した結腸脂肪腫の１例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　An 84-year-old man, who had been found to have a submucosal tumor in the ascending colon two years before, was admitted to our hospital for right lower quadrant abdominal pain and melena. An abdominal computed tomography (CT) scan showed intussusception in the ascending colon, resulting from a fat-density tumor. The intussusception was located by colonoscopy. Since the colonic tumor was enlarged in comparison with two years ago and had an ulcer at the top of the tumor, there was the possibility of malignancy and recurrence of intussusception. He underwent a laparoscopy-assisted right colectomy with lymph node dissection. Pathologically, the tumor of the ascending colon was a benign lipoma.
en-copyright=
kn-copyright=

en-aut-name=NinomiyaTakayuki
en-aut-sei=Ninomiya
en-aut-mei=Takayuki
kn-aut-name=二宮卓之
kn-aut-sei=二宮
kn-aut-mei=卓之
aut-affil-num=1
ORCID=

en-aut-name=OjimaYasutomo
en-aut-sei=Ojima
en-aut-mei=Yasutomo
kn-aut-name=小島康知
kn-aut-sei=小島
kn-aut-mei=康知
aut-affil-num=2
ORCID=

en-aut-name=HaranoMasao
en-aut-sei=Harano
en-aut-mei=Masao
kn-aut-name=原野雅生
kn-aut-sei=原野
kn-aut-mei=雅生
aut-affil-num=3
ORCID=

en-aut-name=OhnoSatoshi
en-aut-sei=Ohno
en-aut-mei=Satoshi
kn-aut-name=大野聡
kn-aut-sei=大野
kn-aut-mei=聡
aut-affil-num=4
ORCID=

en-aut-name=ShiozakiShigehiro
en-aut-sei=Shiozaki
en-aut-mei=Shigehiro
kn-aut-name=塩崎滋弘
kn-aut-sei=塩崎
kn-aut-mei=滋弘
aut-affil-num=5
ORCID=

en-aut-name=NinomiyaMotoki
en-aut-sei=Ninomiya
en-aut-mei=Motoki
kn-aut-name=二宮基樹
kn-aut-sei=二宮
kn-aut-mei=基樹
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=2
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=3
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=4
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=5
en-affil=
kn-affil=広島市立広島市民病院　外科

affil-num=6
en-affil=
kn-affil=広島市立広島市民病院　外科
en-keyword=結腸脂肪腫（lipoma of the colon）
kn-keyword=結腸脂肪腫（lipoma of the colon）
en-keyword=腸重積（intussusception）
kn-keyword=腸重積（intussusception）
en-keyword=腹腔鏡下手術（laparoscopic surgery）
kn-keyword=腹腔鏡下手術（laparoscopic surgery）
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=191
end-page=194
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1930
dt-pub=19300201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=石灰窒素の土壌中に於ける變化に就いて 特にヂシアンヂアミドの土壌中に於ける變化並にその肥効(續)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=村田久次
kn-aut-sei=村田
kn-aut-mei=久次
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=126
cd-vols=
no-issue=7
article-no=
start-page=1562
end-page=1569
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms of resistance to Ad-REIC. First, we isolated resistant clones from a human prostate cancer cell line, PC3, after repeated exposure to Ad-REIC. Infection efficiency of the adenovirus vector and expression level of REIC/Dkk-3 in the resistant clones were similar to those in the parental PC3 cells. By screening for alteration in levels and functional status of proteins involved in Ad-REIC-induced apoptosis, we found that BiP/GRP78, an ER-residing chaperone protein, was expressed at higher levels consistently among resistant cells. Expression levels of BiP and rates of apoptosis induced by Ad-REIC were inversely correlated. Down-regulation of BiP with siRNA sensitized the resistant cells to Ad-REIC in vivo as well as in culture. These results indicate that BiP is a major determinant of resistance to Ad-REIC-induced apoptosis. Thus BiP is useful for diagnosis of inherent and acquired resistance of cancers and also as a target molecule to overcome resistance to the gene therapeutic Ad-REIC.
en-copyright=
kn-copyright=

en-aut-name=TanimotoRyuta
en-aut-sei=Tanimoto
en-aut-mei=Ryuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AbarzuaFernando
en-aut-sei=Abarzua
en-aut-mei=Fernando
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KataokaKen
en-aut-sei=Kataoka
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KuroseKaoru
en-aut-sei=Kurose
en-aut-mei=Kaoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NasuYasutomo
en-aut-sei=Nasu
en-aut-mei=Yasutomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KumonHiromi
en-aut-sei=Kumon
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HuhNam-Ho
en-aut-sei=Huh
en-aut-mei=Nam-Ho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=8
en-affil=
kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

affil-num=9
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
en-keyword=REIC
kn-keyword=REIC
en-keyword=Dkk
kn-keyword=Dkk
en-keyword=apoptosis
kn-keyword=apoptosis
en-keyword=GRP78
kn-keyword=GRP78
en-keyword=ER stress
kn-keyword=ER stress
END

start-ver=1.4
cd-journal=joma
no-vol=284
cd-vols=
no-issue=21
article-no=
start-page=14236
end-page=14244
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090522
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Overexpression of REIC/Dkk-3 in Normal Fibroblasts Suppresses Tumor Growth via Induction of Interleukin-7
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We previously showed that the tumor suppressor gene REIC/Dkk-3, when overexpressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on human cancers through a mechanism triggered by endoplasmic reticulum stress. Adenovirus vectors show no target cell specificity and thus may elicit unfavorable side effects through infection of normal cells even upon intra-tumoral injection. In this study, we examined possible effects of Ad-REIC on normal cells. We found that infection of normal human fibroblasts (NHF) did not cause apoptosis but induced production of interleukin (IL)-7. The induction was triggered by endoplasmic reticulum stress and mediated through IRE1 alpha, ASK1, p38, and IRF-1. When Ad-REIC-infected NHF were transplanted in a mixture with untreated human prostate cancer cells, the growth of the cancer cells was significantly suppressed. Injection of an IL-7 antibody partially abrogated the suppressive effect of Ad-REIC-infected NHF. These results indicate that Ad-REIC has another arm against human cancer, an indirect host-mediated effect because of overproduction of IL-7 by mis-targeted NHF, in addition to its direct effect on cancer cells.
en-copyright=
kn-copyright=

en-aut-name=SakaguchiMasakiyo
en-aut-sei=Sakaguchi
en-aut-mei=Masakiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KataokaKen
en-aut-sei=Kataoka
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AbarzuaFernando
en-aut-sei=Abarzua
en-aut-mei=Fernando
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanimotoRyuta
en-aut-sei=Tanimoto
en-aut-mei=Ryuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=WatanabeMasami
en-aut-sei=Watanabe
en-aut-mei=Masami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ThanSwe Swe
en-aut-sei=Than
en-aut-mei=Swe Swe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KuroseKaoru
en-aut-sei=Kurose
en-aut-mei=Kaoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KashiwakuraYuji
en-aut-sei=Kashiwakura
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OchiaiKazuhiko
en-aut-sei=Ochiai
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NasuYasutomo
en-aut-sei=Nasu
en-aut-mei=Yasutomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=KumonHiromi
en-aut-sei=Kumon
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=HuhNam-ho
en-aut-sei=Huh
en-aut-mei=Nam-ho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=2
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=3
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=4
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=5
en-affil=
kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=6
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=7
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=8
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=9
en-affil=
kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=10
en-affil=
kn-affil=Innovation Center Okayama for Nanobio-Targeted Therapy, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=11
en-affil=
kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=12
en-affil=
kn-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences

affil-num=13
en-affil=
kn-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=2
article-no=
start-page=145
end-page=148
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of esophageal carcinosarcoma with a component of small cell carcinoma
kn-title=小細胞癌成分を含む食道癌肉腫の１切除例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We experienced a case of esophageal carcinosarcoma with a component of small cell carcinoma. The patient was a 73-year-old man. We administered chemotherapy of CDDP+VP-16, and performed an operation after 2 courses of this chemotherapy. Subtotal esophagectomy and reconstruction with the small intestine was performed. More than three years after resection, he remains alive and recurrence-free. There are few cases of esophageal carcinosarcoma and small cell carcinoma. We report this rare case herein.
en-copyright=
kn-copyright=

en-aut-name=TanabeShunsuke
en-aut-sei=Tanabe
en-aut-mei=Shunsuke
kn-aut-name=田辺俊介
kn-aut-sei=田辺
kn-aut-mei=俊介
aut-affil-num=1
ORCID=

en-aut-name=ShirakawaYasuhiro
en-aut-sei=Shirakawa
en-aut-mei=Yasuhiro
kn-aut-name=白川靖博
kn-aut-sei=白川
kn-aut-mei=靖博
aut-affil-num=2
ORCID=

en-aut-name=MaedaNaoaki
en-aut-sei=Maeda
en-aut-mei=Naoaki
kn-aut-name=前田直見
kn-aut-sei=前田
kn-aut-mei=直見
aut-affil-num=3
ORCID=

en-aut-name=OharaToshiaki
en-aut-sei=Ohara
en-aut-mei=Toshiaki
kn-aut-name=大原利章
kn-aut-sei=大原
kn-aut-mei=利章
aut-affil-num=4
ORCID=

en-aut-name=NomaKazuhiro
en-aut-sei=Noma
en-aut-mei=Kazuhiro
kn-aut-name=野間和広
kn-aut-sei=野間
kn-aut-mei=和広
aut-affil-num=5
ORCID=

en-aut-name=SakuramaKazufumi
en-aut-sei=Sakurama
en-aut-mei=Kazufumi
kn-aut-name=櫻間教文
kn-aut-sei=櫻間
kn-aut-mei=教文
aut-affil-num=6
ORCID=

en-aut-name=YanaiHiroyuki
en-aut-sei=Yanai
en-aut-mei=Hiroyuki
kn-aut-name=柳井広之
kn-aut-sei=柳井
kn-aut-mei=広之
aut-affil-num=7
ORCID=

en-aut-name=YamatsujiTomoki
en-aut-sei=Yamatsuji
en-aut-mei=Tomoki
kn-aut-name=山辻知樹
kn-aut-sei=山辻
kn-aut-mei=知樹
aut-affil-num=8
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=9
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院　消化管外科

affil-num=2
en-affil=
kn-affil=岡山大学病院　消化管外科

affil-num=3
en-affil=
kn-affil=岡山大学病院　消化管外科

affil-num=4
en-affil=
kn-affil=岡山大学病院　消化管外科

affil-num=5
en-affil=
kn-affil=岡山大学病院　消化管外科

affil-num=6
en-affil=
kn-affil=岡山大学病院　消化管外科

affil-num=7
en-affil=
kn-affil=岡山大学病院　病理診断科

affil-num=8
en-affil=
kn-affil=川崎医科大学　総合外科学

affil-num=9
en-affil=
kn-affil=川崎医科大学　総合外科学

affil-num=10
en-affil=
kn-affil=岡山大学病院　消化管外科
en-keyword=食道癌肉腫（esophageal carcinosarcoma）
kn-keyword=食道癌肉腫（esophageal carcinosarcoma）
en-keyword=小細胞癌（small cell carcinoma）
kn-keyword=小細胞癌（small cell carcinoma）
en-keyword=食道（esophagus）
kn-keyword=食道（esophagus）
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=59
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Gastric aberrant pancreas with acute pancreatitis treated with surgery
kn-title=膵炎を伴った胃異所性膵の1切除例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We experienced a case of gastric aberrant pancreas with acute pancreatitis. The patient was a 42-year-old man. He was referred to our hospital because of epigastric pain. A CT scan and endoscopic examination revealed a gastric submucosal tumor with inflammation. His serum amylase level was high at 222 IU/l. Endoscopic ultrasonography revealed a hypoechoic mass lesion, 3 cm in diameter, at the body of his stomach. Endoscopic ultrasoundscopy-guided fine needle aspiration was performed. Pathological examination showed pancreatic tissue. So, he underwent partial gastrectomy due to gastric aberrant pancreas with pancreatitis. There are very few cases of gastric aberrant pancreas with pancreatitis on record.
en-copyright=
kn-copyright=

en-aut-name=ShinouraSusumu
en-aut-sei=Shinoura
en-aut-mei=Susumu
kn-aut-name=篠浦先
kn-aut-sei=篠浦
kn-aut-mei=先
aut-affil-num=1
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=2
ORCID=

en-aut-name=SadamoriHiroshi
en-aut-sei=Sadamori
en-aut-mei=Hiroshi
kn-aut-name=貞森裕
kn-aut-sei=貞森
kn-aut-mei=裕
aut-affil-num=3
ORCID=

en-aut-name=MatsudaHiroaki
en-aut-sei=Matsuda
en-aut-mei=Hiroaki
kn-aut-name=松田浩明
kn-aut-sei=松田
kn-aut-mei=浩明
aut-affil-num=4
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=楳田祐三
kn-aut-sei=楳田
kn-aut-mei=祐三
aut-affil-num=5
ORCID=

en-aut-name=YoshidaRyuichi
en-aut-sei=Yoshida
en-aut-mei=Ryuichi
kn-aut-name=吉田龍一
kn-aut-sei=吉田
kn-aut-mei=龍一
aut-affil-num=6
ORCID=

en-aut-name=SatohDaisuke
en-aut-sei=Satoh
en-aut-mei=Daisuke
kn-aut-name=佐藤太佑
kn-aut-sei=佐藤
kn-aut-mei=太佑
aut-affil-num=7
ORCID=

en-aut-name=UtsumiMasashi
en-aut-sei=Utsumi
en-aut-mei=Masashi
kn-aut-name=内海方嗣
kn-aut-sei=内海
kn-aut-mei=方嗣
aut-affil-num=8
ORCID=

en-aut-name=YokomichiNaosuke
en-aut-sei=Yokomichi
en-aut-mei=Naosuke
kn-aut-name=横道直佑
kn-aut-sei=横道
kn-aut-mei=直佑
aut-affil-num=9
ORCID=

en-aut-name=KuiseTakashi
en-aut-sei=Kuise
en-aut-mei=Takashi
kn-aut-name=杭瀬崇
kn-aut-sei=杭瀬
kn-aut-mei=崇
aut-affil-num=10
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=11
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=9
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=11
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
en-keyword=異所性膵 (ectopic pancreas)
kn-keyword=異所性膵 (ectopic pancreas)
en-keyword=迷入膵 (aberrant pancreas)
kn-keyword=迷入膵 (aberrant pancreas)
en-keyword=粘膜下腫瘍 (submucosal tumor)
kn-keyword=粘膜下腫瘍 (submucosal tumor)
en-keyword=急性膵炎 (acute pancreatitis)
kn-keyword=急性膵炎 (acute pancreatitis)
en-keyword=胃 (stomach)
kn-keyword=胃 (stomach)
END

start-ver=1.4
cd-journal=joma
no-vol=37
cd-vols=
no-issue=425
article-no=
start-page=655
end-page=661
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1925
dt-pub=19250630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Ueber die Muratasche Methode für die Serodiagnostik der Syphilis
kn-title=村田氏黴毒血清反應ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Murata hat seine einfache Methode für die Serodiagnose der Syphilis schon mehrmals mitgeteilt (Japan. Zeitschr. f. Dermat. u. Syphilis. Bd. 22 H. 11, Bd. 23 H. 6, Zentralbl. f. Haut- u. Geschlechtskrankh. Bd. 9, S. 133 usw.). Ich habe diese Methode in 743 Fällen geprüft u. die Uebereinstimmung in 694 (93, 4%) mit WR. gefunden. Die Muratasche Methode fällt beim seronegativen primären Stadium und in der negativen Zeit von WR. nach der antisyphilitischen Behandlung oft positiv aus; also scheint sie empfindlicher als WR. zu sein. Sie reagiert besser im inaktiven Serum als im aktiven. Doch ist sie sowohl im hämolytischen als auch im getrübten Serum vom schwach positiven Blut schwer ablesbar, wenn sie auch dabei im stark positiven Serum leicht verständlich ist. Ich bin überzeugt davon, dass sie einfache u. gute Methode ist und der WR. gute Beihilfe leisten kann.
en-copyright=
kn-copyright=

en-aut-name=FujiharaAkira
en-aut-sei=Fujihara
en-aut-mei=Akira
kn-aut-name=藤原皓
kn-aut-sei=藤原
kn-aut-mei=皓
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=39
cd-vols=
no-issue=11
article-no=
start-page=1881
end-page=1889
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1927
dt-pub=19271130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=WaR., M. T. R. und Muratasche Reaktion im Liquor der Syphilis
kn-title=黴毒ノ腦脊髓液ニ於ケルWassermann, Meinicke竝ニ村田諸氏ノ反應ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=WaR. im Liq. verhält sich wie folgendes: bei 3 Fällen im primären Stadium negativ; unter 12 Fällen im sekundären Stadium nur bei einem Fall von Alopecia specifica positiv; bei 6 Fällen im tertiären Stadium und bei 15 frühlatenten Fällen alle negativ; unter 56 spätlateuten Fällen bei 6 Fällen positiv; unter 83 angeboren luischen Fällen bei 3 Fällen positiv; und bei 2 Fällen von Tabes dorsalis positiv. Muratasche Reaktion und M. T. R. sind zwar empfindlich als Seroreaktion, jedoch gilt dies der Liquorreaktion wenig. Die Untersteinsche Modifikation der M. T. R. ist ebensowenig empfindlich bei uns.
en-copyright=
kn-copyright=

en-aut-name=OmichiNaoichi
en-aut-sei=Omichi
en-aut-mei=Naoichi
kn-aut-name=大道直一
kn-aut-sei=大道
kn-aut-mei=直一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=4
article-no=
start-page=979
end-page=989
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1938
dt-pub=19380430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Concerning M.K.B.II. A case of liquor cerebro-spinalis.
kn-title=脊髓液ニ於ケルM.K.R.llニ就テ 附 Browning氏,Kahn氏竝ニ村田氏法トノ比較
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WadaMasayuki
en-aut-sei=Wada
en-aut-mei=Masayuki
kn-aut-name=和田雅之
kn-aut-sei=和田
kn-aut-mei=雅之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=12
article-no=
start-page=2790
end-page=2797
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1940
dt-pub=19401231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On the Influence Bagnon-Stark on Non specificity in the Syphilitical Seroreaction
kn-title=Bagnon-Starkガ黴毒血清反應特ニ村田氏反應及ビMeinicke氏第2清澄反應(M.K.R. II).ノ非特異性ニ及ボス影響ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) The seronegative rabbitsserum in the Browning, Murata and M.K.R. II. tests is not influenced by the injection of Bagnon-Stark and this result remains unaltered even after three consecutive injection. 2) The effect of this medicament upon the nop-specificity in the Murata and the M.K.R. II. tests is observed after the first injection. The non-specificity in the Murata test disappears or shows negative tendency in 30 seconds after the injection, and the similar result is recognised in 1 hour after the injection in the M.K.R. II. test. 3) The duration of time before the disappearance of non-specificity in the two tests varies according the strength of the reaction. The weak positiveness before the experiment disappears in 3 hours after the injection in either of the two tests. But in the case of strong positiveness 10 hours is required to shows the negative tendency after the injection, and in either of the two cases the complete disappearance of non-specificity is observed in 24 hours after the infection. 4) The effect of Bagnon-Stark on the rabbit syphilis that has shown strong positiveness in the Browning, Murata and M.K.R. II. tests is wholly null and void. 5) The disappearance of non-specificity in the Murata and the M.K.R. II. tests by the injection of Bagnon-Stark is probably due to the alteration of organic metabolism as well as to the fall of temperature in the rabbit.
en-copyright=
kn-copyright=

en-aut-name=OhmichiMineo
en-aut-sei=Ohmichi
en-aut-mei=Mineo
kn-aut-name=大道峰雄
kn-aut-sei=大道
kn-aut-mei=峰雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=10
article-no=
start-page=1987
end-page=2007
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1954
dt-pub=19541030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=THE CLINICAL AND EXPERIMENTAL STUDY ON THE COURSE OF SYPHILIS WITH PENICILLIN PART III THE INFLUENCE OF PENICILLIN ON THE COURSE OF PRECIPITATION (MURATA AND KAHN) IN EXPERIMENTAL RABBIT SYPHILIS
kn-title=梅毒の経過に対するペニシリンの臨床的並に実験的研究 第3編 実験的家兎梅毒における沈降反応（村田，Kahn）の経過に及ぼすペニシリンの影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I have injected penicillin in rabbits in which spirochaeta pallida was oculated at the period when the precipitation (Murata and Kahn) turned positive and observed the transition of the serum reaction, alteration of the local state and disappearance of spirochaeta from the local area and obtained the following results: 1) In the cases in which 50,000 U. of penicillin were injected, the influence of penicillin on the 3 reactions (WaR, Murata and Kahn) was rather unstable and the term needed for the 3 reactions to turn negative was prolonged, i.e., WaR turned negative in 66.5 days after the oculation (54.5 days after the injection), Murata's reaction in 94.5 days (82.5 days after the injection), and Kahn's reaction in 91.0 days (79.0 days after the injection). 2) In the 100,000 U. injected cases, WaR turned negative in 63.0 days after the oculation (50.7 days after the injection), Murata's reaction in 84.0 days (71.7 days after injection), Kahn's reaction in 92.8 days (80.5 days after injection). 3) In the cases in which 200,000 U. were injected, a definite effect of penicillin on the serum reaction was observed when compared with the previous 2 groups, i.e., WaR turned negative in 11.6 days after oculation (7.0 days after injection), Murata's reaction in 28.0 days (18.6 days after injection), and Kahn's reaction in 46.6 days (37.3 days after injection). 4) In the observation of the effect of penicillin on the local state: in 50,000 U. injected cased, stuntedness of the local state and the prolongation of the incubation could be observed and the local state cured in 36.0 days, in 100,000 U. injected cases, the prolongation of incubation could be observed but the local state occured and took 25.7 days to disappear and in 200,000 U. injected cases, the local state was completely prevented and the syphilitic local symptoms did not appear. 5) 200,000 U. of penicillin showed a definite effect on the existence of spirochaeta, i.e., the spirochaeta conld not be detected at all, and in 50,000 U. injected cases, the effect of injection was not distinct and they disappeared in 16.0 days in the former cases and in 9.2 days in the latter cases. 6) The recurrens of the serum reaction and the local state could not be observed during the observation of 4 months on the average. Comparing the above results with those described in Part II, where the injections were given at the period when WaR turned positive, the following results were obtained: 7) Concerning the 50,000 U. and 100,000 U. injected cases, the term needed for the serum reaction to turn negative was prolonged in the cases in which the injections were given at the period when precipitation turned positive, when compared with the cases in which injections were given at the period when WaR turned positive, therforee the time required for the absorption of local state and the disappearance of spirochaeta was also prolonged. 8) In the observation of 200,000 U. injected cases: WaR turned negative in 42.6 days after oculation (21.3 days after inlection), Murata in 56 days (34.6 days after injection), Kahn in 60.6 days (39.3 days after injection) in the cases in which injections were given at the period when WaR turned positive, and in the cases where injections were made at the period when precipitation turned positive, WaR turned negative in 11.6 days after oculation (7 days after injection), Murata in 28.0 days (18.6 days after injection), Kahn in 46.6 days (37.3 days after injection), i.e., distinct reduction could be observed in the latter cases. 9) In 200,000 U. injected cases, a remarkable and regular effect of penicillin could be observed when compared with other 2 groups, and especialy in the cases in which injections were given at the period when the precipitation turned positive the effect was more distinct. 10) In 50,000 U. and 100,000 U. injected cases no distinct and regular effect of penicillin could be observed.
en-copyright=
kn-copyright=

en-aut-name=MoriokaYuji
en-aut-sei=Morioka
en-aut-mei=Yuji
kn-aut-name=森岡祐治
kn-aut-sei=森岡
kn-aut-mei=祐治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=117
cd-vols=
no-issue=14
article-no=
start-page=2963
end-page=2970
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20046
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Differential localization of the centromere-specific proteins in the major centromeric satellite of Arabidopsis thaliana
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p>The 180 bp family of tandem repetitive sequences, which constitutes the major centromeric satellite in Arabidopsis thaliana, is thought to play important roles in kinetochore assembly. To assess the centromere activities of the 180 bp repeats, we performed indirect fluorescence immunolabeling with antibodies against phosphorylated histone H3 at Serl0, HTR12 (Arabidopsis centromeric histone H3 variant) and AtCENP-C (Arabidopsis CENP-C homologue) for the A. thaliana cell cultures. The immunosignals from all three antibodies appeared on all sites of the 180 bp,repeats detected by fluorescence in situ hybridization. However, some of the 180 bp repeat clusters, particularly those that were long or stretched at interphase, were not fully covered with the signals from anti-HTR12 or AtCENP-C. Chromatin fiber immunolabeling clearly revealed that the centromeric proteins examined in this study, localize only at the knobs on the extended chromatin fibers, which form a limited part of the 180 bp clusters. Furthermore, outer HTR12 and inner phosphohistone H3 (Ser1O) localization at the kinetochores of metaphase chromosomes suggests that two kinds of histone H3 (a centromere variant and a phosphorylated form) might be linked to different roles in centromere functionality; the former for spindle-fiber attachment, and the latter for chromatid cohesion.</p>

en-copyright=
kn-copyright=

en-aut-name=ShibataFukashi
en-aut-sei=Shibata
en-aut-mei=Fukashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MurataMinoru
en-aut-sei=Murata
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Japan Science and Technology, Kawaguchi

affil-num=2
en-affil=
kn-affil=Okayama  University
en-keyword=180 bp repeat
kn-keyword=180 bp repeat
en-keyword=Arabidopsis thaliana
kn-keyword=Arabidopsis thaliana
en-keyword=Centromere
kn-keyword=Centromere
en-keyword=proteins
kn-keyword=proteins
en-keyword=Histone H3
kn-keyword=Histone H3
en-keyword=Phosphorylation
kn-keyword=Phosphorylation
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=2
article-no=
start-page=107
end-page=111
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2006
dt-pub=200604
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Resistance imparted by vitamin C, vitamin e and vitamin B12 to the acute hepatic glycogen change in rats caused by noise.
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of vitamin C, vitamin E and vitamin B12 on the noise-induced acute change in hepatic glycogen content in rats were investigated. The exposure of rats to 95 dB and 110 dB of noise acutely reduced their hepatic glycogens. Vitamin C (ascorbic acid) and vitamin E (alpha -tocopherol) attenuated the noise-inducedacute reduction in the hepatic glycogen contents. This result suggests that antioxidants could reduce the change via reactive oxygen species. Vitamin B12 (cobalamin) delayed the noiseinduced change, a finding that suggests that vitamin B12 could postpone the acute change via compensating for vitamin B12 deficiency.
en-copyright=
kn-copyright=

en-aut-name=ZhuBei-Wei
en-aut-sei=Zhu
en-aut-mei=Bei-Wei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=PiaoMei-Lan
en-aut-sei=Piao
en-aut-mei=Mei-Lan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ZhangYu
en-aut-sei=Zhang
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HanSong
en-aut-sei=Han
en-aut-mei=Song
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AnQing-Da
en-aut-sei=An
en-aut-mei=Qing-Da
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TadaMikiro
en-aut-sei=Tada
en-aut-mei=Mikiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=Dalian Institute of Light Industry

affil-num=2
en-affil=
kn-affil=Okayama Univeristy

affil-num=3
en-affil=
kn-affil=Dalian Institute of Light Industry

affil-num=4
en-affil=
kn-affil=Okayama University

affil-num=5
en-affil=
kn-affil=Dalian Institute of Light Industry

affil-num=6
en-affil=
kn-affil=Okayama University

affil-num=7
en-affil=
kn-affil=Okayama University
en-keyword=α-tocopherol
kn-keyword=α-tocopherol
en-keyword=ascorbic acid
kn-keyword=ascorbic acid
en-keyword=cobalamin
kn-keyword=cobalamin
en-keyword=hepatic glycogen
kn-keyword=hepatic glycogen
en-keyword=noise
kn-keyword=noise
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Stage-specific embryonic antigen-4を用いた歯の幹細胞の同定
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataSatoko
en-aut-sei=Murata
en-aut-mei=Satoko
kn-aut-name=村田智子
kn-aut-sei=村田
kn-aut-mei=智子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=342
end-page=347
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of Image and Layered Structure on Web Search Performance -Evaluation on the Basis of Movement Distance of Mouse Pointer-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this paper was to explore the effects of image addition and layered structure on Web search performance on the basis of the search time and the movement trajectory of mouse pointer. The difference of search characteristics between young and older adults was also examined. Older adults tended to take more time to search for the linked item especially when the layered structure was deep. For the deep layered structure, both young and
older adults allocate more time to think which items should be selected than to operate a mouse. For all participants, less mouse movement was observed for the image-based link condition than for the character-based link condition. This tendency was more remarkable for older adults. Moreover, it was clarified that more mouse movement was observed with the increase of the number of hyperlinks per Web page. When the layered structure was shallow, the following difference of mouse operation
characteristics between young and older adults was observed: Older adults made an attempt to locate the
search item while moving a mouse simultaneously. On
the other hand, young adults began to move a mouse
after locating the search item.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=2
ORCID=

en-aut-name=HayamiTakehito
en-aut-sei=Hayami
en-aut-mei=Takehito
kn-aut-name=早見武人
kn-aut-sei=早見
kn-aut-mei=武人
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TakahashiRina
kn-aut-sei=Takahashi
kn-aut-mei=Rina
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University

affil-num=4
en-affil=
kn-affil=Japan Digital Laboratory Co. Ltd.
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=336
end-page=341
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparison of Performance among Different Situations of Operation in Web Display - Comparison of Behavioral Features between Young and Older Adults -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to clarify the situation where older adults feel inconvenient when carrying out various Web operations, the differences of Web search behavior between young and older adults were examined using Web sites with different layered structures. The following two situations were used to address the issue above: (1) operation of a "Back" button, and (2) operation of a hyperlink. When the operation of "Back" button was necessary, the task completion time of older adults was 2.3 times as long as that of young adults. Such a difference must be obtained, because older adults need more time to recognize and understand the layered structure. When operation "Back" button in a raw, the task completion time of older adults was 3.9 times as long as that of young adults. Moreover, the task completion time of older adults increased in case of searching in the deep layered Web site due to the slower and declined cognition and judgment. When selecting a hyperlink, the task completion time of older adults was 12.1 times as long as that of young adults. On the basis of this tendency, we inferred that older adults took more time and became more careful when selecting a hyperlink.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=TakahashiRina
kn-aut-sei=Takahashi
kn-aut-mei=Rina
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Japan Digital Laboratory Co. Ltd.
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=330
end-page=335
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of Thumb-Operated Dial-Type Integrated Switch for Automobile and its Effectiveness
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A thumb-operated dial-type integrated switch for automobile use was developed, and the task completion time for this type of integrated switch was compared with that for a traditional integrated switch. The rotation torque of an encoder and the rotation diameter were selected as experimental parameters. An attempt was made to identify the optimal and recommended condition of rotation torque and diameter. It was demonstrated that the thumb-operated dial-type integrated switch lead to faster task completion time as compared with the traditional integrated switch. As for the thumb-operated dial-type integrated switch, the
following combination of the rotation torque and the rotation diameter were not proper: diameter of 20mm for the rotation torque of 12.9mN・m and 9.2mN・m, and diameters of 20mm and 40mm for the rotation torque of 8.6 mN・m. It was also suggested that the optimal condition cannot be identified using the condition of the rotation force only, and that the optimal condition must be determined taking into account the combination of the rotation torque and the rotation diameter.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=WangShuguang
kn-aut-sei=Wang
kn-aut-mei=Shuguang
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=320
end-page=325
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fundamental study for constructing a system to assist the left visual field of older drivers - Effectiveness of the alternative of the left front side-view mirror by the central visual field -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The purpose of this paper is to establish the basics of the systems that assist visibility of the left visual field for older drivers. The display was located either the left which corresponded to a left side mirror, or within the central effective visual field. Participants performed multiple tasks where tracking task using a steering wheel was a primary task, and judgment of situations using a left or front display was a secondary task. How the display location affected the judgment performance was explored for both young and older adults. We counted the number of the warning during the tracking task and measured the percentage correct reaction to displayed stimulus and reaction sensitivity. We investigated how these measures ware affected by age and display location. Mean warning number during the tracking tasks, the percentage correct recognition of situations and d' was affected age and display location. The central display was found to increase the percentage correct recognitions of situations.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=UchidaYohei
en-aut-sei=Uchida
en-aut-mei=Yohei
kn-aut-name=内田洋平
kn-aut-sei=内田
kn-aut-mei=洋平
aut-affil-num=2
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=316
end-page=319
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Skill of Eye-Hand Coordination in Calligraphy - Difference of Skill of Hand-Eye Coordination between Expert and Novice -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A system that can simultaneously measure the movement of a brush tip and the eye-gaze position during a calligraphy task has been developed. The system consisted of a device to measure the location of a brush tip and an eye tracker. Using this system, the skill of hand-eye coordination was measured for an expert and novices. It has been clarified that an expert of calligraphy distributes the eye-gaze over a wider area and gazes in advance a part that should be written next. In other words, an expert does not gaze at the brush tip but at the part that should be written at the next stage.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=YamamotoGoshiro
en-aut-sei=Yamamoto
en-aut-mei=Goshiro
kn-aut-name=山本豪士朗
kn-aut-sei=山本
kn-aut-mei=豪士朗
aut-affil-num=2
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=312
end-page=315
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Basic study on relationship between SI, EI and human error characteristics
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recently, accidents or scandals due to organizational violation-based error frequently occur. One of the causes might be maladjustment to environmental changes surrounding organization from relief to global society. In this study, the following proposition was hypothesized: Social intelligence (SI), ability to evaluate appropriately the reliability of others, ability to carry out communication smoothly in organization, and emotional aspects (behavior on the basis of emotion or reasonability) are important factors and keys to prevent violation-based organizational error. A questionnaire which included items related to social intelligence (SI: social awareness and social facility), emotional intelligence (EI), ability to evaluate the reliability of others, ability to communicate smoothly in organization, behavioral characteristics (emotional- or reasonability-based behavior), and ability to make decisions and judge situations. An attempt was made to verify the hypothesis above by a survey using the questionnaire.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=YamamotoKohei
en-aut-sei=Yamamoto
en-aut-mei=Kohei
kn-aut-name=山本康平
kn-aut-sei=山本
kn-aut-mei=康平
aut-affil-num=2
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=306
end-page=311
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effectiveness of the menu selection method for eye-gaze input system - Comparison between young and older adults -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although the opportunity of older adults to use personal computer is increased more and more, the operation of a personal computer with a mouse is very annoying for older adults who cannot move his or her arm smoothly and effectively due to declined motor function. An attempt to move a cursor by an eye-gaze input system has been carried out as one solution to this problem. Until now, a menu selection method suitable for an eye-gaze input system has not been clarified. In this study, an effective menu selection for the eye-gaze input system was identified as a basic design parameter to develop a Web browser using an eye-gaze input system. Concretely, a menu selection method, that is, improved quick glance menu selection (I-QGMS) was proposed. The effectiveness was evaluated by means of the pointing accuracy, the pointing time, and the psychological rating on usability. On the basis of the evaluation experiment, the proposed I-QGMS was found to be
effective especially for older adults.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=302
end-page=305
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Basic Study for Development of Web Browser suitable for Eye-gaze Input System - Identification of Optimal Click Method -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this study, alternative methods of mouse click operation were discussed. The eye-gaze input system was used. The effectiveness was compared among three alternative methods of mouse click operation. The alternative methods in the eye-gaze input system included the eye fixation, the press of space button, and the wink (blink). The percentage correct recognition, the pointing time, the subjective evaluation of usability was used as evaluation measures. The arrangement of targets (vertical or horizontal) and the age were also considered as experimental factors, and it was explored how these factors affected the pointing performance. The percentage correct recognition of the horizontal direction was higher than that of the vertical direction. The pointing time became longer as follows: eye-gaze input system with eye fixation, mouse, eye-gaze input system with press of space button, and eye-gaze input system with wink. The age factor was found not to affect the pointing time so
remarkably.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=326
end-page=329
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Educational plans in nursing departments The current state of nurse development
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the recent diversification of career paths in nursing, the establishment of a career development plan (CDP) system for nurses is becoming more important for improving the quality of nursing. The present study, conducted on chief nurses in general hospitals in Japan, aimed to ascertain how nursing education fosters the individual career development of nurses. As a result, We understood the next matter. 1) Training for mid-level nurses is provided by most hospitals, primarily in the form of in-hospital training. 2) More than 90% of the hospitals surveyed provided individual counseling for career development, either as needed or periodically. 3) The proportion of hospitals with fewer than 200 nurses that prepared individual educational plans was 7%; the proportion of hospitals with more than 210 nurses that prepared individual educational plans was 24% on average.4) By taking into account "nurse development", job rotation is viewed as part of nursing education. Next, we proposed the new method for evaluation of CDP to individual nurses using N-S table.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OzawaYukio
kn-aut-sei=Ozawa
kn-aut-mei=Yukio
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=KitaokaMasatoshi
kn-aut-sei=Kitaoka
kn-aut-mei=Masatoshi
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Kanagawa University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Kanagawa University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=258
end-page=263
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Design method of Cockpit module in consideration of switch type, location of switch and display information for older drivers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this paper, the effects of switch type, location of switch, and display information on the primary driving task and the secondary switch operation were investigated. The switch type included an integrated and a non-integrated switch. These switches were located on the front left, on the left side, or around a steering wheel. We prepared three displays with different display information (2.0, 4.1, and 5.9 bit). The tracking error, the mean operation time, the percentage of correct answer, NASA-TLX mental workload, and the subjective evaluation of
usability were measured in order to analyze how these measures were affected by experimental factors above. The results suggested that young adults are better than older adults at both abilities on processing displayed information and operating switches. The integrated switch was found to affect driving performance than the non-integrated switch, and had little influence on switch operation. In addition, it was clarified that the switch located around a steering wheel had little influence on driving performance. Low display information was also found not to affect the performance.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=YamadaKeita
en-aut-sei=Yamada
en-aut-mei=Keita
kn-aut-name=山田啓太
kn-aut-sei=山田
kn-aut-mei=啓太
aut-affil-num=2
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=254
end-page=257
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Visual information processing characteristics of drivers in prediction of dangerous situation - Comparison among novice, expert and non-licensed person -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study was to examine the difference of visual information processing in KYT (Kiken Yochi Training) among novice, expert and non-licensed persons. In KYT tasks, participants were required to search for a potentially dangerous part using a static image under driving situations. The location of fixation point and the time series change of eye gaze were measured using an eye
camera. In order to detect the difference of visual
information processing among three groups above, an important area that the participants must pay attention to with the highest priority was set for each static image. The time until the eye gaze fixates to the important area, and the ratio of the fixation time to the total search time were detected. Using these measures, the difference of visual information processing among three groups was clarified. Moreover, for novice and non-licensed participants, it was also explored whether a lecture related to KYT would improve the efficiency of visual information processing. The time until the eye gaze fixates to the important area was longer for the non-licensed participants than for the experienced participants. The learning effect by means of a KYT lecture was also observed.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=HayamiTakehito
en-aut-sei=Hayami
en-aut-mei=Takehito
kn-aut-name=早見武人
kn-aut-sei=早見
kn-aut-mei=武人
aut-affil-num=2
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=248
end-page=253
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Prevention of drowsy driving by means of warning sound
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Traffic accidents occur due to inattentive driving such as drowsy driving. A variety of support systems that make an attempt to prevent inattentive driving are under development. The development of a system to prevent drowsy driving using auditory or tactile alarm system is undertaken. It is essential to detect the low arousal state and warn drivers of such a state so that drowsy can be prevented. EEG (Electroencephalography) was used to evaluate how an arousal level degraded with time for eight participants under a low arousal level. Mean power frequency (MPF) was calculated to evaluate an arousal level. The value of MPF was compared between high and low arousal levels. The difference of arousal effect among four warning sounds was examined. As a result, there was no significant difference of arousal effect among four alarm sounds. The alarm sound was found to temporarily heighten participants' arousal level.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MatsudaYusuke
en-aut-sei=Matsuda
en-aut-mei=Yusuke
kn-aut-name=松田佑介
kn-aut-sei=松田
kn-aut-mei=佑介
aut-affil-num=2
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=242
end-page=247
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Basic study on effectiveness of tactile interface for warning presentation in driving environment
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study was to get insight into the development of tactile interface for automobile warning system. In other words, it was investigated whether the important driving information in the right and left peripheral visual fields can be recognized faster using tactile warning system as compared with auditory warning system. The participants were required to simultaneously carry out a tracking task (main task), a switch pressing task such as selection of light-on function, and a judgment task of important information which randomly appeared to the right or left peripheral visual field. The tracking error, the number of lane deviation, the percentage correct of switch pressing, and the response time to right and left peripheral stimulus were measured. It was examined how age, the modality of alarm presentation (no alarm, auditory, and tactile), the addition of direction in alarm presentation, and the existence of disturbance sound, and the location of tactile sensor (steering or foot) affected the measures above. The young adults performed better than older adults. The response time was not affected by the modality of alarm presentation, and the disturbance sound. The
addition of direction of alarm presentation affected the performance. The tactile sensor attached to the foot led to faster response than that attached to the steering wheel.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=TanakaKohki
en-aut-sei=Tanaka
en-aut-mei=Kohki
kn-aut-name=田中弘毅
kn-aut-sei=田中
kn-aut-mei=弘毅
aut-affil-num=2
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=236
end-page=241
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091111
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of location of information presentation in pedestrian detection system on visibility and performance
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A few pedestrian warning systems for automobiles are in practical use. It has not been clarified where is best suited for the location of pedestrian information presentation. The most effective location of information presentation in pedestrian detection system was investigated. In other words, the location that assured the fastest cognition of pedestrian information was clarified. The locations of information presentation in pedestrian detection system were front glass, front display of cockpit module, and left side display of cockpit module (like car navigation system). The participants were required to pay attention to the predetermined front area as well as the randomly presented pedestrian information while carrying out a virtual driving task (tracking task) and a secondary switch pressing task such as selection of wiper function. We also
investigated the effect of alarm sound presented to the participants together with the visual pedestrian information on the cognition time of pedestrian information. As a result, the front glass was most
suitable for the presentation of pedestrian information. The presentation of pedestrian information to the front glass led to high visibility and faster pedestrian cognition time.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=AratamaShinsaku
en-aut-sei=Aratama
en-aut-mei=Shinsaku
kn-aut-name=新玉晋作
kn-aut-sei=新玉
kn-aut-mei=晋作
aut-affil-num=2
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=182
end-page=185
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of State of Eye Movements before Saccade on Efficiency of Response to Stimulus - Comparison of Search Efficiency between Fixation and Smooth Pursuit Situations -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In this study, how the state of eye movement before saccade affected the response to a stimulus was explored. The state of eye movement before saccade was either smooth pursuit or fixation. The smooth pursuit was carried out both clockwise and counter-clockwise. Using an eye-tracking system, the eye movement during the experimental task was monitored. The response time to a stimulus was measured. On the basis of the eye movement data (coordinate), the eye movement velocity, the eye movement acceleration, and the latency of eye movement were obtained. When smooth pursuit was carried out before saccade, the response to a stimulus which appears as a result of saccade was faster. More concretely, the response time of smooth pursuit condition was faster than that of fixation condition. The latency of the smooth pursuit condition tended to be faster than that of the fixation condition. Some implications for the application of the results to the traffic safety or automotive ergonomics were given.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=HayamiTakehito
en-aut-sei=Hayami
en-aut-mei=Takehito
kn-aut-name=早見武人
kn-aut-sei=早見
kn-aut-mei=武人
aut-affil-num=2
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University

affil-num=3
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=176
end-page=181
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Development of the Computer Aided Remanufacturing System (CARES) Part I: Software Development (Phase I) and a Simulation Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The environment bills that passed by the legislators triggered a new dimension towards the manufacturers to consider producing eco – friendly product. This paper presents the developed software of the remanufacturing evaluation system so-called "Computer – Aided Remanufacturing Evaluation System (CARES)". The software is developed by integrating an analytic hierarchy process (AHP) with case based reasoning (AHP – CBR) approach. The result of the simulation study showed that the maximum similarity between the input case and the retrieve case is 80%. The evaluation system recommended that mirror cover,
mirror base and mirror holder should be remanufactured.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=GhazalliZakri
kn-aut-sei=Ghazalli
kn-aut-mei=Zakri
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=170
end-page=175
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Proposal for Town Development in Aged Society
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=According to the Aged day commemorative report issued in September of 2007 from the Ministry of Internal Affairs and Communication, the population of over sixty five years old attained the historical record high of 27.44 million or 21.5% of total population. On the other hand, the many of shopping malls with large parking have been located in suburbs with expanding of suburban residential area and the effect of motorization. In addition, the growth of remote shopping such as internet and catalog one, helps accelerate the decline of old shopping malls. However, these malls give the only one life-line to the elder and disabled population. In this paper, we discuss on the way of maintaining this life-line for elder and disabled one from the study of questionnaire surveys for visitors of two shopping mall in Wakamatsu-ward and Tobata-ward, Kitakyushu, the gate way city to Kitakyushu in Fukuoka Prefecture. Some of methodology is proposed to facilitate
revitalization of local areas as the result of this study.
en-copyright=
kn-copyright=

en-aut-name=MatsuoTetsuko
en-aut-sei=Matsuo
en-aut-mei=Tetsuko
kn-aut-name=松尾哲子
kn-aut-sei=松尾
kn-aut-mei=哲子
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=164
end-page=169
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Production lot size models for perishable seasonal products
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Seasonal items like fruits, fish, winter cosmetics, fashion apparel, etc. generally exhibits different demand patterns at various times during the season. Production and inventory planning must reflect this property for cost effectiveness and optimization of resources. This paper presents two production-inventory models for perishable seasonal products that minimize total inventory costs. The models obtains optimal production run time and optimal production quantity for cases when the production rate is constant and when it is allowed to vary with demand. The products are assumed to deteriorate at an exponential rate and demand for them follows a three-phase ramp type pattern during the season. Numerical examples and sensitivity analysis are carried out. Production run time and production quantity obtained by the model were found to be independent of cost parameters. The variable production rate strategy was also found to give lower inventory costs and production quantity than the constant
production rate strategy.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IbraheemAbdul
kn-aut-sei=Ibraheem
kn-aut-mei=Abdul
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=158
end-page=163
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An optimal EOQ model for perishable products with varying demand pattern
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The demand pattern for most perishable products varies during their life cycle in the market. These variations must be properly reflected in inventory management in order to prevent unnecessary stock-out or excess inventory with associated increase in cost. In this paper, a multi-period economic order quantity (EOQ) model for managing the
inventory of perishable items having varying demand pattern is presented. The model was formulated using a general ramp-type demand function that allows three-phase variation in demand pattern. These phases represent the growth, the steady and the decline phases commonly experienced by the demand for most products during their life cycle in the market. The model generates replenishment policies that guarantees optimal inventory cost for all the phases. Numerical experiments and sensitivity analysis were carried out to demonstrate the
suitability of the model for a wide range of seasonal products. Result of the experiments revealed that the points at which demand pattern changes are critical points in managing inventory of products with ramp type demand.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IbraheemAbdul
kn-aut-sei=Ibraheem
kn-aut-mei=Abdul
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2009
cd-vols=
no-issue=1
article-no=
start-page=348
end-page=353
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20091112
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of Drowsiness by HRV Measures - Proposal of prediction method of low arousal state -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study was to propose a useful prediction method of drowsy state of drivers, so that the result is applicable to the development of ITS (Intelligent Transportation System) that can warn drivers of their low arousal state and to prevent driving under low arousal level from occurring. The EEG (electroencephalography) and ECG (electrocardiography) during a monotonous task was measured, and it was investigated how these measures change under the low arousal (drowsy) state. The EEG measurement was added to in order to monitor arousal level more the time series of mean power frequency of EEG was plotted on X-bar control chart. Heart rate variability (HRV) measure RRV3 were derived on the basis of R-R intervals (interbeat intervals) obtained from ECG. Using a Bayesian probability, we tried to predict the timing when the participant actually felt drowsy. As a result, the prediction accuracy differed by the state of participant. When the drowsiness of participant was remarkable, the prediction method was effective to some extent. On the other hand, the proposed method could not predict the drowsy state reliably when the participant did not feel drowsiness to a larger extent.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=HiramatsuYasutaka
en-aut-sei=Hiramatsu
en-aut-mei=Yasutaka
kn-aut-name=平松靖隆
kn-aut-sei=平松
kn-aut-mei=靖隆
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Okayama University

affil-num=2
en-affil=
kn-affil=Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=7
article-no=
start-page=2443
end-page=2456
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=1958
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Medullary Blood Vessel Construction and Canals of Cartilage in Human Foetus Long Bones Part 2. Medullary Blood Vessel Construction and Canals of Cartilag in Lower Leg Bones, Humerus, and Forearm Bones
kn-title=人胎児長管骨に於ける骨髄血管構造並びに軟骨管に関する研究 第2編 下腿骨,上腕骨及び前腕骨の骨髄血管構造並びに軟骨管について
en-subtitle=
kn-subtitle=
en-abstract=Using transparent specimens and serial sections prepared from lower leg bones, humerus. and forearm bones of sixty human foetuses age ranging from second embryonic month to the last, after injection of dye, the construction of medullary blood vessels and canals of cartilage have been studied and the following are the results. 1. The time of bone marrow growth and the appearance time of nutrient arteries and veins are fixed in all these bones and it coincides with that in the femur. 2. The number and site of nutrient foramen are generally fixed in respective bone. 3. The direction of nutrient vessels penetrating through the bone wall is fixed in tibia; but in other bones it is not fixed and no regular changes according to monthly progress can be recognized. 4. The manner of branching and the running of medullary arterial branches are fixed according to the shape of each bone, and there are anastomoses among arterial branches. 5. The medullary venous system is consisted of main venous sinuses and venous meshworks communicated with these sinuses. 6. Metaphyseal arteries, with exception in the proximal metaphysis of the radius, appear in the metaphysis of each bone during the period between the sixth and seventh embryonic months, and these arteries are anastomosed with branches of diaphyseal arteries. 7. Canals of cartilage of each bone enter in a fixed order according to the size of respective epiphysis.
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataSeizo
en-aut-sei=Murata
en-aut-mei=Seizo
kn-aut-name=村田精三
kn-aut-sei=村田
kn-aut-mei=精三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=7
article-no=
start-page=2427
end-page=2442
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Medullary Blood Vessel Construction and Canals of Cartilage in Human Foetus Long Bones Part 1. Medullary Blood Vessel Construction and Canals of Cartilage in the Femur
kn-title=人胎児長管骨に於ける骨髄血管構造並びに軟骨管に関する研究 第1編 大腿骨の骨髄血管構造並びに軟骨管について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With transparent specimens and serial sections prepared from femurs of sixty human foetuses age ranging from second embryonic month to the last, after injection of dye, the medullary blood vessel construction and canals of cartilage in the femur have been studied and the following are the results. 1. At the time when bone marrow starts to grow, the vascular mesenchymal tissue enters from several places of the bone collar. The time is about the middle of the third embryonic month. 2. The site of nutrient foramen is located on the posterior surface of the long bone occupying one third of the center. In most cases two nutrient arteries are found in a femur, generally accompanied by nutrient veins. 3. Arterial branches in bone marrow during the first half of foetal life run more or less in straight line whereas during the latter half they run in undulating formation. These arterial branches are seen anastomosing with one another. 4. The venous system in bone marrow is consisted of main venous sinuses and venous meshworks connecting with them. 5. In the latter half of foetal life when there are two nutrient arteries in a femur, their branches are anast omosed with one another. 6. Metaphyseal vessels appear in the latter half of foetal life and these metaphyseal arteries are anastomosed with branches of diaphyseal arteries. 7. Canals of cartilage can be seen entering into proximal and distal epiphysis from the beginning of the fourth embryonic month. 8. In the last month of foetal life an ossification center can be recognized in the distal epiphysis, and a part of canals of cartilage is connected with the ossification center.
en-copyright=
kn-copyright=

en-aut-name=MurataSeizo
en-aut-sei=Murata
en-aut-mei=Seizo
kn-aut-name=村田精三
kn-aut-sei=村田
kn-aut-mei=精三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=7-8
article-no=
start-page=551
end-page=575
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1967
dt-pub=19670830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Prevention of Side-Effects of the Anticancer Agent
kn-title=制癌剤の副作用防止に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Preventive measure of the side-effects of an anticancer agent, Mitomycin-C (MMC), was investigated on Ehrlich tumor mice, by using several agents which had originally no tumoricidal effects except last one: such as orotic acid (OA), chloroquine orotate (QO), magnesium chloride (Mg), Sarvinal (SV), dihydrostreptomycin (SM), and so-called OX-substance (OX; unsaturated fatty acid fraction extracted from the liver of X-Ray irradiated rabbit). Results obtained were as follows. 1. Mg had a most preventive effect on the reduction of WBC due to MMC, following by SM, CO and SV. 2. On the fluctuation of RBC, SM, Mg, OA and CO showed better results. 3. No agents tested were effective on the prevention of reduction in platelets. 4. No unwilling decrease in tumor-effects were noted in these agents. 5. Survival time was markedly extended in case of using SM. Summarizing the results obtained above, streptomycin was a most useful agent for the prevention of side-effects of Mitomycin-C. Under the fundamental investigation, streptomycin was clinically used in case of giving Mitomycin-C, and the side-effects were remarkably reduced as seen in the experiment. Further studies would have to be continued on the other anticancer agents.
en-copyright=
kn-copyright=

en-aut-name=MurataMasahiko
en-aut-sei=Murata
en-aut-mei=Masahiko
kn-aut-name=村田雅彦
kn-aut-sei=村田
kn-aut-mei=雅彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=204
end-page=209
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20081211
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Care for Home-bound Older Adults and Revitalization of Local Shopping Arcade
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The Japanese Ministry of Internal Affairs and Communications announced, on Respect-for-the Aged Day in September, 2005, that the population over 65 is over 20 % of the nation’s total population. The Ministry also announced on June 1, 2006, that the special total birth rate in Japan recorded the lowest value of 1.25. If the birth rate continues to decrease faster than estimated, the ratio of older adults to the nation’s total population will increase faster than expected. As new housing and large-scaled supermarkets are planned and constructed in the suburbs, older adults, the poor and the disabled people who cannot afford to drive for utilizing suburb supermarkets are forced into old inactive residential area and shopping arcade. Older adults hope to communicate with others, which can be facilitated by advanced technology. The case studies in this study show that older adults can satisfy such needs by communicating with shop owners in local shopping arcade. The secret for the revitalization of local shopping arcade lies in the care for home-bound older adults. We recommend a concept of cozy compact city where home-bound older adults can actively enjoy their lives in and out of their home and the local shopping arcade can be revitalized.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=MatsuoTetsuko
kn-aut-sei=Matsuo
kn-aut-mei=Tetsuko
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Intelligent Mechanical Systems, Division of Industrial Innovation Sciences

affil-num=2
en-affil=
kn-affil=Department of Intelligent Mechanical Systems, Division of Industrial Innovation Sciences
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=198
end-page=203
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20081211
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A PERISHABLE INVENTORY MODEL WITH UNKNOWN TIME HORIZON
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Traditionally, the time (planning) horizon over which
the inventory for a particular item will be controlled is often assumed to be known (finite or infinite) and the total inventory cost is usually obtained by summing up the cost over the entire time horizon. However, in some inventory situations the period over which the inventory will be controlled are difficult to predict with certainty, as the inventory problems may not live up to or live beyond the assumed planning horizon, thereby affecting the optimality of the model. This paper presents a deterministic perishable inventory model for items with linear trend in demand and constant deterioration when time horizon is unknown, unspecified or unbounded. The heuristic model obtains replenishment policy by determining the ordering schedule to minimize the total cost per unit time over the duration of each schedule. A numerical example and sensitivity analysis are given to illustrate the model.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=A.I..ABDUL
kn-aut-sei=A.I..
kn-aut-mei=ABDUL
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=A.E.OLULEYE
kn-aut-sei=A.E.
kn-aut-mei=OLULEYE
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Intelligent Mechanical Systems, Division of Industrial Innovation Sciences

affil-num=2
en-affil=
kn-affil=Department of Intelligent Mechanical Systems, Division of Industrial Innovation Sciences

affil-num=3
en-affil=
kn-affil=University of Ibadan
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=191
end-page=197
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20081211
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effectiveness of Instruction using Electronic Circuit Simulation Software
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Traditional teaching (lecturing) method on the design of electronic circuit provides learners with little satisfaction, because they cannot check and confirm the validity of electronic circuit they have designed. A better way to acquire design skills is to actually make the designed electronic circuit and test the validity of design. In spite of the usefulness of such a practical approach, it has a disadvantage that there is only limited time for teaching (lecturing) and it is difficult to fabricate electronic circuit, perform electronic measurement, and test the validity of design in the limited lecture period. An alternative to overcome these disadvantages is to use simulation software that enables learners (students) to operate functionally the designed electronic circuit and verify the appropriateness of design. The aim of this study was to examine the usefulness of simulation approach and clarify some problems related to such an approach.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=OhtaYukio
kn-aut-sei=Ohta
kn-aut-mei=Yukio
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Intelligent Mechanical Systems, Division of Industrial Innovation Sciences

affil-num=2
en-affil=
kn-affil=Department of Intelligent Mechanical Systems, Division of Industrial Innovation Sciences
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=127
end-page=132
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effectiveness of Eye-Gaze Input System 
-Identification of Conditions that Assures High
Pointing Accuracy and Movement Directional Effect-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The condition under which high accuracy is assured when using an eye-gaze input system was identified.
It was also investigated how direction of eye movement
affected the performance of an eye-gaze input system. Here,
age, the arrangement of targets (vertical and horizontal),
the size of a target, and the distance between adjacent
rectangles were selected as experimental factors. The
difference of pointing velocity between a mouse and an eyegaze input system was larger for older adults than for
young adults. Thus, an eye-gaze input system was found to
be effective especially for older adults. An eye-gaze input
system might compensate for the declined motor functions
of older adults. The pointing accuracy of an eye-gaze input
system was higher in horizontal arrangement than in
vertical arrangement. The distance between targets of more
than 20 pixels was found to be desirable for both vertical
and horizontal arrangements. For both the vertical and
horizontal arrangements, the target size of more than
40pixels led to higher accuracy and faster pointing time for
both young and older adults. For both age groups, it tended
that the pointing time for the lower direction was longer
than that for other directions.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MiyakeTakashi
en-aut-sei=Miyake
en-aut-mei=Takashi
kn-aut-name=三宅貴士
kn-aut-sei=三宅
kn-aut-mei=貴士
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=121
end-page=126
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Usability of Site Map in Web Design 
– Design of Site Map that is Friendly to Older Adults-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The information or data for Web page design that is useful, in particular, to older adults was provided in this study. The proper design of site map is necessary to enhance the usability and reduce the number of getting lost in Web navigation especially for older adults. However, no design guideline on what site map is proper exists. The usability of six types of site maps was compared as a function of age.
The six types of site maps included (1) vertical tree
type, (2) horizontal tree type (A), (3) horizontal tree
type (B), (4) table type, (5) radial type, and (6)
itemized type. The usability was evaluated using search time, subjective rating of usability, and eye movement characteristics (fixation duration and fixation number). The age affected the evaluation measures. The horizontal type (B) was found to lead to faster search time and fewer fixation numbers. Moreover, this type of site map was found to make the difference of search time, fixation number, and
fixation duration between young and older adults smaller. The result indicated that the vertical arrangement of site map, especially horizontal type (B) was proper for both young and older adults, and this should be incorporated into the Web page design guidelines. The results can be utilized as a universal design guideline for providing a site map that is friendly to both young and older adults.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=117
end-page=120
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of Shape of pen on Usability
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using electromyography (EMG) analysis and psychological rating, the usability of pen was evaluated. The experimental factors wewre the pen diameter (three levels:8mm, 11mm, and 13.8mm). The length of pen tip was fixed to 14mm. Surface EMG was recordes from extensor digitorum and flexxor digitorum superficialis. The EMG before and after a long-hour writing task was measured to evaluate the fatigue of forearm using % MVC (Mean Voluntary Contraction), mean power frequency (MPF) and psychological rating on usability. Concerning % MVC and MPF, the difference before and the experimental task were used for the evaluation. The evaluation value corresponded to subtraction of value after the experimental task from that before the experimental task. As a result of a one-way (pen diameter) ANOVA, no significant main effects of pen diameter were for both EMG evaluation measures. As for the psychological rating on usability, Kruscal-Wallis non-parametric test was carried out. The psychological rating on ease of grip revealed a significant main effect of pen diameter. A pen with a diameter of 11mm was found to have a significant higher rating score.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MizushimaKensuke
en-aut-sei=Mizushima
en-aut-mei=Kensuke
kn-aut-name=水島健介
kn-aut-sei=水島
kn-aut-mei=健介
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
en-keyword=universal design
kn-keyword=universal design
en-keyword=usability
kn-keyword=usability
en-keyword=EMG
kn-keyword=EMG
en-keyword=pen diameter
kn-keyword=pen diameter
en-keyword=length of pen tip
kn-keyword=length of pen tip
en-keyword=psychological rating
kn-keyword=psychological rating
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=111
end-page=116
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Optimal Slope of Touch Panel 
－Comparison between Young and Older Adults－
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Touch panels are becoming increasingly common alternatives to traditional indirect devices such as mouse. However, older adults are not willing to utilize touch-panel based ATM or ticket machines, because they feel that using ATM properly is too difficult and annoying for them. The aim of this study was to identify an optimal slope of touch panel interface. Whether using a direct input device by older adults would lead to smaller difference of performance between preferred and non-preferred hands was also examined. For both young and older adults, the slope conditions of 30, 45, and 60 degrees, and the target size
of 60 x 60 pixels were found to lead to higher performance.
With the increase of movement distance d, the movement
velocity tended to increase for both age groups. The
difference of movement velocity between young and older
adults tended to increase with the increase of movement
distance d. The difference of performance between nonpreferred and preferred hands was smaller relative to their young counterparts. Moreover, the difference of
performance between young and older adults was smaller
when using a touch panel than when using a mouse.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=TakahashiRina
en-aut-sei=Takahashi
en-aut-mei=Rina
kn-aut-name=高橋里奈
kn-aut-sei=高橋
kn-aut-mei=里奈
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=103
end-page=110
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Web Design that is Friendly to Older Adults 
– Effects of Perceptual, Cognitive and Motor Functions and
Display Information on Web Navigation Time –
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Older internet users are increasing more and more
world widely. The information accessibility standard for Web
contents (JIS X 8341-3) had been established. Although many
researchers are pursuing the usability of Web site, we cannot design a usable Web site only by improving Web pages. One of the reasons is inferred that we didn’t consider perceptual, cognitive, and motor functions especially of older adults in the design of Web pages. The aim of this study was to propose a method to evaluate perceptual, cognitive, and motor ability and
to explore the effect of perceptual, cognitive and motor abilities, and display information on Web navigation. We proposed a method to calculate display information on the basis of number of links. It was explored how display information, age, and the test score of perceptual, cognitive, and motor abilities influenced Web navigation time. This effect was examined using a multiple regression analysis. Display information influenced Web navigation performance for both young and older adults. The more the quantity of display information was, the longer the Web navigation time was. In addition to this tendency, the depth of display layer was found to affect the Web navigation time especially for older adults. We found that
the perceptual, cognitive, and motor abilities of older adults, in particular, the spatial memory, spatial rotation ability, and mouse operation ability, led to longer Web navigation time. These results implies the necessity of designing Web site for older adults that considers the decline of perceptual, cognitive, and motor ability.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=TakahashiRina
en-aut-sei=Takahashi
en-aut-mei=Rina
kn-aut-name=高橋里奈
kn-aut-sei=高橋
kn-aut-mei=里奈
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=99
end-page=102
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of Drowsiness by HRV Measures 
- Basic Study for Drowsy Driver Detection -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study was to identify a useful measure to estimate an arousal level of drivers, to apply the result to develop ITS (Intelligent Transportation System) that can warn drivers of their low arousal state and to prevent driving under low arousal level from occurring and contribute to the reduction of traffic accidents. The EEG (electroencephalography) and ECG(electrocardiography) during a monotonous task was measured, and it was investigated how these measures change under the low arousal (drowsy) state. The time series of mean power frequency of EEG was plotted on X-bar control chart. Heart rate variability (HRV) measures RRV3 and RRV8-3 were derived on the basis of R-R intervals (interbeat intervals) obtained from ECG. Under the low arousal state (drowsy state), the mean power frequency tended to be lower than central line (CL) and range between CL and lower control limit (LCL). In accordance with this, RRV3 and RRV8-3 tended to increase under the low arousal (drowsy) state, which means that the parasympathetic nervous system became dominant under drowsy states.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=HiramatsuYasutaka
en-aut-sei=Hiramatsu
en-aut-mei=Yasutaka
kn-aut-name=平松靖隆
kn-aut-sei=平松
kn-aut-mei=靖隆
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=95
end-page=98
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of Drowsiness by EEG analysis 
- Basic Study on ITS Development for the Prevention of Drowsy Driving -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of this study was to identify a useful measure to estimate an arousal level of drivers, to apply the result to develop ITS (Intelligent Transportation System) that can warn drivers of their low arousal state and to prevent driving under low arousal level from occurring and contribute to the reduction of traffic accidents. The EEG(electroencephalography) during a monotonous task was measured, and it was investigated how these measures change under the low arousal (drowsy) state. The time series of mean power frequency of EEG was plotted on Xbar control chart. Under the low arousal state (drowsy state), the
mean power frequency tended to be lower than central line (CL) and range between CL and lower control limit (LCL). Under the worst case, the mean power frequency was lower than LCL. The ratio of such intervals to total measurement period tended to increase under drowsy state. The mean power frequency was found to be effective for evaluating drowsiness of drivers.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=NishijimaKazuyuki
en-aut-sei=Nishijima
en-aut-mei=Kazuyuki
kn-aut-name=西嶋和之
kn-aut-sei=西嶋
kn-aut-mei=和之
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
en-keyword=ITS
kn-keyword=ITS
en-keyword=drowsiness
kn-keyword=drowsiness
en-keyword=EEG
kn-keyword=EEG
en-keyword=control chart
kn-keyword=control chart
en-keyword=blink
kn-keyword=blink
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=89
end-page=94
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Design of vehicle instrumental panel for older adults 
- Effects of viewing distance, display from, and switch arrangement on secondary task performance -
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of age, viewing distance, arrangement of switches and display form on performance to design of display and control systems friendry to older adults were discussed. A dual-task experimemt was conducted in which the primary task was first-irder tracking. The secondary tasks included control of an air conditioner, the operation of a radio, and the operation of a CD/MD, by means of a steering wheel mounted swich. The switch was either vertical or cross arrangement. In both-hands switch arrangement condition, the operation was carried out with two hands using both left vertical switch and right cross switch. In one-hand swith arrangement condition, the operation was carried out with only one hand using either left or right cross switch. The display was arranged in front of a participant. The display form was either left or right display. The viewing distance conditions were 60, 80, and 100cm. When the right display form was used, both one-hand (using only right cross switch) were selected. When the left display form was used, both one-hand (using only left cross swith) and two-hand arrangements (using both left vertical and right cross switch) were selected. As predicted, age affected the performance measures ( percentage correct, task completion time, and tracking error). The viewing distance also affected performance (percentage correct), Both display form and switch arrangement also affected performance (task completion time). Such results should be taken into account when designing display and control systems in man-vehicle systems.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=YamaguchiSatoshi
en-aut-sei=Yamaguchi
en-aut-mei=Satoshi
kn-aut-name=山口智司
kn-aut-sei=山口
kn-aut-mei=智司
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=83
end-page=88
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of Automotive Control-Display System by means of MentalWorkload
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of age, task difficulty on performance and mental workload were discussed in order to provide design guideline of automobile display that is friendly to older adults from the viewpoints of mental attention, speed and accuracy. A dual-task experiment was conducted in which the
primary task was first order tracking. The secondary
tasks included selection of function (easy condition),
and control of an air conditioner, the operation of a
radio, and the operation of a CD/MD (difficult condition), by means of a steering wheel mounted switch. The display was arranged in front of a participant. Age affected the performance measures and heart rate variability (HRV). As for the young adults, the task completion time did not differ significantly among easy and difficult (one-, two-, and three-layered) conditions. The performance of older
adults was affected by task difficulty. The HRV
measures such as CV (coefficient of variance) and
RRV8-3 during the task showed different tendency
between young and older adults. As for the young
group, the HRV measures did not differ significantly
between the four task levels (easy, one-, two-, and
three-layered). This confirmed that the task difficulty
did not induce different mental workload to young
adults. On the other hand, as for the older adults, the
HRV measures tended to increase with the increase of
task difficulty. Although it appears that mental
workload was lessened with the increase of task
difficulty, such an interpretation was contradictory to
the results on performance. This phenomenon was
interpreted that the difficult task condition was
overloaded for older adults, and was beyond the limit
of mental effort. Based on the results, it could be
concluded that the difficult task condition is not
proper for older adults.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

en-aut-name=MoriwakaMakoto
en-aut-sei=Moriwaka
en-aut-mei=Makoto
kn-aut-name=森若誠
kn-aut-sei=森若
kn-aut-mei=誠
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=77
end-page=82
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of the evaluation system for automobile
remanufacturing
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By 2015, the EU directives required the automobile
manufacturers to produce a vehicle that contains reusable and / or recoverable parts at least 95% of total weight. In the developed countries, the legislative issue the take – back policy which requires the manufacturers to consider the end – of – life (EOL) of their products at early design stage. The goal of this paper is to propose a framework of development methodology that focuses on integrated design for remanufacturing evaluation system. This system supports the automobile product design and development at the early design phase. The proposed method is divided into two phases. The first phase aims to identify the suitable EOL process. The second phase aims to verify the most economical EOL process. The proposed method incorporates the
Case base Reasoning [CBR] into the remanufacturing techniques. It is expected that the proposed method can provide the EOL with decision support during designing the automobile parts at the early design stage.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=GhazalliZakri
kn-aut-sei=Ghazalli
kn-aut-mei=Zakri
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=71
end-page=76
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=200812
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of vehicle display information and switch type
on usability -Comparison between young and older adults-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Recently, in-vehicle highly intelligent information devices are rapidly widespread. Under such circumstances, the accurate evaluation of the effect of display information and switch type on driving performance is important in order to develop in-vehicle information devices that do not menace the safety. In this article, we present a basic idea to estimate properly the effect of the vehicles display information and the switch system on driving performance. We compared the index such as mean task completion time, subjective rating on usability, tracking error, and NASA-TLX workload between young and older adults.
The results suggest that young will be better than older adults at both abilities on processing displayed information and operating the switch. We were found that there was a significant interaction between the switch types and installation location. On the other hand, the displayed information did not affect the performance.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=WangShuguang
kn-aut-sei=Wang
kn-aut-mei=Shuguang
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University
END

start-ver=1.4
cd-journal=joma
no-vol=2008
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20081210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Human Error Management Paying Emphasis on Decision Making and Social Intelligence 
-Beyond the Framework of Man-Machine Interface Design-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=How latent error or violation induces a serious accident has been reviewed and a proper addressing measure of this has been proposed in the framework of decision making, emotional intelligence (EI) and social intelligence (SI) of organization and its members. It has been clarified that EI and SI play an important role in decision making. Violations frequently occur all over the world, although we definitely understand that we should not commit violations, and a secret to prevent this might exist in the enhancement of both social intelligence and reliability. The construction of social structure or system that supports organizational efforts to enhance both social intelligence and reliability would be essential. Traditional safety education emphasizes that it is possible to change attitudes or mind toward safety by means of education. In spite of this，accidents or scandals frequently occur and never decrease. These problems must be approached on the basis of the full understanding of social intelligence and limited reasonability in decision making. Social dilemma (We do not necessarily cooperate in spite of understanding its importance, and we sometimes make decision not to select cooperative behavior. Non-cooperation gives rise to a desirable result for an individual. However, if all take non-cooperative actions, undesirable results are finally induced to all.) must be solved in some ways and the transition from relief (closed) society to global (reliability) society must be realized as a whole. New social system, where cooperative relation can be easily and reliably obtained, must be constructed to support such an approach and prevent violation-based accidents.
en-copyright=
kn-copyright=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=村田厚生
kn-aut-sei=村田
kn-aut-mei=厚生
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1267
end-page=1286
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=High-power scanning electron microscopy of senile plaques, neurofibrillary tangles, and Pick bodies
kn-title=老人斑，Alzheimer 神経原線維変化，Pick 嗜銀球の超高倍率走査電顕的観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Senile plaques, neurofibrillary tangles, and Pick bodies were examined by modified scanning electron microscopy from a low-power to an ultra high-power range. The amyloid core of the typical plaques was found to be composed of radially arranged rod-shaped components, which were made up of dense aggregation of meandering moniliform amyloid filaments about 15 nm in diameter. Bands with a mesh-like structure were observed outside the crown around the core. The compact plaques were nearly identical to the core alone of the typical plaques. The primitive plaques as a whole were analogous to the mesh-like structure around the typical plaques, and they both contained aggregates of filaments closely resembling amyloid fibers. In neurofibrillary tangles, the flamed shape stretched straight to the peripheries, the globosed shaped formed vortices, and only bundles of parallel filaments were observed. PHFs that constituted these structures were 25-30 nm in diameter, and many appeared constricted to a diameter of about 15 nm by rotating 180° to the left at a cycle of 70-80 nm. In Pick bodies, filaments were interwoven and formed a mesh-like structure, numerous granules were attached the filaments. Some filaments were large, being 20-30 nm in diameter, others were thin, being about 15nm in diameter.
en-copyright=
kn-copyright=

en-aut-name=KuyamaKeisuke
en-aut-sei=Kuyama
en-aut-mei=Keisuke
kn-aut-name=久山圭介
kn-aut-sei=久山
kn-aut-mei=圭介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
en-keyword=Senile Plaque
kn-keyword=Senile Plaque
en-keyword=Alzheimer's neurofibrillary changes
kn-keyword=Alzheimer's neurofibrillary changes
en-keyword=Pick body
kn-keyword=Pick body
en-keyword=scanning electron microscopy
kn-keyword=scanning electron microscopy
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=1-2
article-no=
start-page=165
end-page=176
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Magnetic resonance image database system and its clinical applications
kn-title=MR 画像データベースシステムの開発とその臨床応用に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A magnetic resonance (MR) image detabase system has been developed. The purpose of this paper is to present this system and its application. It consists of an image processing system and database system to handle data of clinical cases and a medical knowledge base. Using the image processing system and the database system with stored data of clinical cases, the MR image data of cases can be retrieved by diagnosis as well as ID number, patient's name, etc., and MR images can be processed. By using the database system with the medical knowledge base, differential diagnoses can be offered.
en-copyright=
kn-copyright=

en-aut-name=NoriyasuToshiaki
en-aut-sei=Noriyasu
en-aut-mei=Toshiaki
kn-aut-name=則安俊昭
kn-aut-sei=則安
kn-aut-mei=俊昭
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
en-keyword=MRI
kn-keyword=MRI
en-keyword=database
kn-keyword=database
en-keyword=medical image
kn-keyword=medical image
en-keyword=knowledge base
kn-keyword=knowledge base
en-keyword=PACS
kn-keyword=PACS
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=5-6
article-no=
start-page=639
end-page=649
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Long-term follow-up study od total hip replacement in rheumatoid arthritis
kn-title=慢性関節リウマチにおける全人工股関節置換術長期成績に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A long-term follow up study was performed on 125 total hip replacements (THR) in 95 rheumatoid patients. The average follow up time was 8 years and 5 months, ranging from 5 to 17 years. Except in 26 cases of death or 9 incomplete histories at the follow-up, 62 cases were investigated both clinically and radiologically. For the operations, two types of prostheses (Charnley and C-Muller ) were used. According to the Japan Orthopaedic Association (JOA) hip score, the preoperative score improved from 32.9 to 57.1 points at the final postoperative evaluation. In the radiological assessment using the method by Nagaya and Uno, a clear zone was seen around the acetabular cup in 82.2% of the hips and around the femoral stem in 53.2%. Rate of loosening corresponding to stage Ⅲ and Ⅳ was 20.2% in the acetabular side and 32.9% in the femoral side. Charnley-type group was better than C-Muller type both in clinical and radiological assessments. Twelve cases had lost walking ability. As postoperative complications, deep infections occurred in 4 hips, femoral shaft fracture in 4 hips, dislocation in 1 hip and revision due to aseptic loosening in 4 hips. THR may be useful for rheumatoid patients and improve the quality of life in the case of long-term disease if careful pre-and post-operative care is provided.
en-copyright=
kn-copyright=

en-aut-name=OosakiKazuhiko
en-aut-sei=Oosaki
en-aut-mei=Kazuhiko
kn-aut-name=大﨑和彦
kn-aut-sei=大﨑
kn-aut-mei=和彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学教室
en-keyword=慢性関節リウマチ
kn-keyword=慢性関節リウマチ
en-keyword=全人工股関節置換術
kn-keyword=全人工股関節置換術
en-keyword=長期追跡調査
kn-keyword=長期追跡調査
en-keyword=合併症
kn-keyword=合併症
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=3-4
article-no=
start-page=297
end-page=310
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clinical and histological studies on steroid-induced avascular necrosis of the femoral head, especially in ststemic lupus erythematosus
kn-title=ステロイド性大腿骨頭壊死症の病態に関する研究―全身性エリテマトーデス(SLE)を中心に―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Clinical and radiological studies were performed on avascular necrosis of the femoral head (ANF) in 220 hips 140 patients including 51 hips of 28 patients with systemic lupus erythe-matosus (SLE group). Sixty-nine hips of 41 patients wee treated with corticosteroid adminis-tration (S group) and 100 hips of 71 patients without corticosteroid administration (Non-S group). All patients with SLE were treated with corticosteroid adminstration. Thirty-one femoral heads (11 heads of SLE group, 9 heads of S group and 11 heads of Non-S group) were resected at operations nad studied histologically. Seventy-seven hips at an early stage showed that collapse of the femoral heads occurred in 80% without 3 years and no differences were found among these group. In the SLE group, bilateral involvement, multiple bone necrosis and predilection for young females were apparent. Collapse of the femoral head and subcapital fractures were more frequently seen in the SLE group. Histologically, almost all heads even in the SLE group showed repair process such as enchondral ossification and appositional bone formation, while the heads with subcapital fracture showed no such no such changes.
en-copyright=
kn-copyright=

en-aut-name=UsuiMasaaki
en-aut-sei=Usui
en-aut-mei=Masaaki
kn-aut-name=臼井正明
kn-aut-sei=臼井
kn-aut-mei=正明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学教室
en-keyword=大腿骨頭壊死症
kn-keyword=大腿骨頭壊死症
en-keyword=全身性エリテマトーデス(SLE)
kn-keyword=全身性エリテマトーデス(SLE)
en-keyword=病態
kn-keyword=病態
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=FAKの局在性と大腸癌の癌化との関連
kn-title=Localization of FAK is related with colorectal carcinogenesis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataToshihiro
en-aut-sei=Murata
en-aut-mei=Toshihiro
kn-aut-name=村田年弘
kn-aut-sei=村田
kn-aut-mei=年弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=単球におけるＬＰＳ誘導性の新規ＴＮＦ-α転写制御因子に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataHiromi
en-aut-sei=Murata
en-aut-mei=Hiromi
kn-aut-name=村田裕美
kn-aut-sei=村田
kn-aut-mei=裕美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=1-2
article-no=
start-page=73
end-page=80
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=19930227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of anthracycline-anthraquinone analogues in the treatment of lung cancer using colony assay Part 1. Comparison of antitumor activity of anthracycline-anthraquinone analogues in human lung cancer cell lines
kn-title=Colony assay 法を用いた肺癌化学療法における Anthracycline-anthraquinone 系薬剤の有効性に関する研究 第1編 ヒト肺癌細胞株に対する Anthracycline-anthraquinone 系薬剤の殺細胞効果の比較
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In an attempt to evaluate the antitumor activity of new anthracycline-anthraquinone analogues ; aclarubicin (ACR), tetrahydropyranyl adriamycin (THP-ADM), and mitoxantrone(MIT), these analogues were compared with adriamycin(ADM) in terms of 70% lethal dose by colony assay using five human lung cancer cell lines, which had been established and maintained in our laboratory. The human lung cancer cell lines tested were EBC-1, an epidermoid cancer cell line, ABC-1, an adenocarcinoma cell line, and SBC-1, -2, and -3, small cell cancer cell lines. In general, the EBC-1 established from a patient tumor showing resistance to ADM was the least sensitive to the drugs tested, and SBC-3 established from a patient tumor with no prior chemotherapy was the most sensitive to the drugs. In antitumor activity, both ACR and THP-ADM appeared to be superior to ADM and MIT, suggesting the clinical usefulness of these drugs in the treatment of lung cancer.
en-copyright=
kn-copyright=

en-aut-name=NumataTakeyuki
en-aut-sei=Numata
en-aut-mei=Takeyuki
kn-aut-name=沼田健之
kn-aut-sei=沼田
kn-aut-mei=健之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=肺癌細胞株
kn-keyword=肺癌細胞株
en-keyword=colony assay
kn-keyword=colony assay
en-keyword=anthracycline
kn-keyword=anthracycline
en-keyword=anthraquinone
kn-keyword=anthraquinone
END

start-ver=1.4
cd-journal=joma
no-vol=108
cd-vols=
no-issue=11-12
article-no=
start-page=343
end-page=351
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A causal model analysis of the quality of life in patients with cerebrovascular diseases at home
kn-title=パス解析モデルによる在宅脳血管障害患者の QOL の解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The purpose of this study was to elucidate the factors of subjective quality of life (QOL) for the patients with cerebrovascular diseases and to investigate the usefulness of path analysis as an analystic method for the subjective QOL. A separate factor analysis was carried out for the 67 patients using the questionnaire developed by a research team of the Ministry of Health and Welfare in 1992. As a result, three fectors could be confirmed. They were feeling of satisfaction, sense of psychological security, and volision and vitality. In addition, the internal consistency of scaling observed suggests the validity of the evaluation, using these three factors, of subjective QOL of those patients. As a result of effect of extended ADL on the feeling of satisfaction, the sense of psychological security and the volision and vitality, the degree of the direct effects and that of the indirect effects through depressive state could be clarified on these three factors. These results suggest the usefulness of path analysis as the analystic method for the subjectice QOL of patients with cerebrovascular diseases at home.
en-copyright=
kn-copyright=

en-aut-name=KagawaKoujiro
en-aut-sei=Kagawa
en-aut-mei=Koujiro
kn-aut-name=香川幸次郎
kn-aut-sei=香川
kn-aut-mei=幸次郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=cerebrovascular disease
kn-keyword=cerebrovascular disease
en-keyword=QOL
kn-keyword=QOL
en-keyword=extended ADL
kn-keyword=extended ADL
en-keyword=depression
kn-keyword=depression
en-keyword=path analysis
kn-keyword=path analysis
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=7-8
article-no=
start-page=751
end-page=756
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199408
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case report of esophageal cyst
kn-title=食道囊腫の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Esophageal cyst is a relatively rare disease and about 91 cases have been reported in Japan. We report a new case of esophageal cyst. Tha patient was a 36-year-old male who complained of nausea and vomiting. We performed esophagography, endoscopy, endoxcopic echography, CT and MRI and found a cystic lesion in the lower esophagus. We made the diagnosis of an esophageal cyst and performed operation. The tumor was in the esophageal muscle but did not have a commissure to the esophageal lumen. We extirpated it with esophageal muscle and repaired the muscle defect with diaphragma. This tumor, 7.5×5.0cm in size, was a monolocular cyst and contained brown muddy material. Microscopic findings revealed a ciliated columnar epithelium and squamous epithelium in the cyst wall but cartilage was not found. The cyst was covered with double smooth muscle layers. It was difficult to differentiate an esophageal cyst from a paraesophageal bronchogenic cyst but these histological findings suggested that this cyst was an esophageal cyst.
en-copyright=
kn-copyright=

en-aut-name=IshiiYasunori
en-aut-sei=Ishii
en-aut-mei=Yasunori
kn-aut-name=石井泰則
kn-aut-sei=石井
kn-aut-mei=泰則
aut-affil-num=1
ORCID=

en-aut-name=InoueFumiyuki
en-aut-sei=Inoue
en-aut-mei=Fumiyuki
kn-aut-name=井上文之
kn-aut-sei=井上
kn-aut-mei=文之
aut-affil-num=2
ORCID=

en-aut-name=BanHidetoshi
en-aut-sei=Ban
en-aut-mei=Hidetoshi
kn-aut-name=伴秀利
kn-aut-sei=伴
kn-aut-mei=秀利
aut-affil-num=3
ORCID=

en-aut-name=KamikawaYasuaki
en-aut-sei=Kamikawa
en-aut-mei=Yasuaki
kn-aut-name=上川康明
kn-aut-sei=上川
kn-aut-mei=康明
aut-affil-num=4
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室
en-keyword=食道囊腫
kn-keyword=食道囊腫
en-keyword=esophageal cyst
kn-keyword=esophageal cyst
en-keyword=気管支食道囊腫
kn-keyword=気管支食道囊腫
en-keyword=bronchial-esophageal cyst
kn-keyword=bronchial-esophageal cyst
en-keyword=foregut cyst
kn-keyword=foregut cyst
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=7-10
article-no=
start-page=107
end-page=114
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19981030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Case report of a gastric glomus tumor
kn-title=胃癌を伴った胃グロームス腫瘍の1例―本邦報告例の文献的考察―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The patient was a 67-year-old man who vomitted blood during therapy while hospitalized due to an asthma attack. He underwent a gastric examination, which detected a submucosal tumor on the greater curvature of the gastric antrum and gastric cancer on the lesser curvature. This tumor was diagnosed as a glomus tumor by postoperative pathological examination. In Japan, glomus tumors of stomach have been reported in 50 cases including our case. The mean age of patients was 48 years (23 to 74). Nineteen patients were male and 31 female. The main symptom was upper abdominal pain. The tumors developed in the submucosal layer of the greater curvature in the antrum and the mean size was 2.8 cm. A Angiography revealed hypervascularization  and endoscopic ulutasonography showed spheroid tumors localized in the muscle layer. Proeoperative histological diagnoses were often difficult. Two cases including our patient were associated with gastric cancer.
en-copyright=
kn-copyright=

en-aut-name=FukudaKazuma
en-aut-sei=Fukuda
en-aut-mei=Kazuma
kn-aut-name=福田和馬
kn-aut-sei=福田
kn-aut-mei=和馬
aut-affil-num=1
ORCID=

en-aut-name=AsanoHiroaki
en-aut-sei=Asano
en-aut-mei=Hiroaki
kn-aut-name=浅野博昭
kn-aut-sei=浅野
kn-aut-mei=博昭
aut-affil-num=2
ORCID=

en-aut-name=OtaniYuu
en-aut-sei=Otani
en-aut-mei=Yuu
kn-aut-name=大谷裕
kn-aut-sei=大谷
kn-aut-mei=裕
aut-affil-num=3
ORCID=

en-aut-name=MiyagutiNaoyuki
en-aut-sei=Miyaguti
en-aut-mei=Naoyuki
kn-aut-name=宮口直之
kn-aut-sei=宮口
kn-aut-mei=直之
aut-affil-num=4
ORCID=

en-aut-name=NishiHideyuki
en-aut-sei=Nishi
en-aut-mei=Hideyuki
kn-aut-name=西英行
kn-aut-sei=西
kn-aut-mei=英行
aut-affil-num=5
ORCID=

en-aut-name=ManoMasayuki
en-aut-sei=Mano
en-aut-mei=Masayuki
kn-aut-name=間野正之
kn-aut-sei=間野
kn-aut-mei=正之
aut-affil-num=6
ORCID=

en-aut-name=KomatubaraShoukiti
en-aut-sei=Komatubara
en-aut-mei=Shoukiti
kn-aut-name=小松原正吉
kn-aut-sei=小松原
kn-aut-mei=正吉
aut-affil-num=7
ORCID=

en-aut-name=KishimotoTakumi
en-aut-sei=Kishimoto
en-aut-mei=Takumi
kn-aut-name=岸本卓巳
kn-aut-sei=岸本
kn-aut-mei=卓巳
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山労災病院外科

affil-num=2
en-affil=
kn-affil=岡山労災病院外科

affil-num=3
en-affil=
kn-affil=岡山労災病院外科

affil-num=4
en-affil=
kn-affil=岡山労災病院外科

affil-num=5
en-affil=
kn-affil=岡山労災病院外科

affil-num=6
en-affil=
kn-affil=岡山労災病院外科

affil-num=7
en-affil=
kn-affil=岡山労災病院外科

affil-num=8
en-affil=
kn-affil=岡山労災病院内科
en-keyword=胃グロームス腫瘍
kn-keyword=胃グロームス腫瘍
en-keyword=胃癌
kn-keyword=胃癌
en-keyword=Gastric Glomus Tumor
kn-keyword=Gastric Glomus Tumor
END

start-ver=1.4
cd-journal=joma
no-vol=109
cd-vols=
no-issue=7-12
article-no=
start-page=157
end-page=164
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19971225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A comparative study of obesity and life styles between Japanese and Chinese children
kn-title=日本と中国における学童の肥満と生活習慣に関する比較研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In 1993 and 1994, a questionnaire survey was conducted on elementary school students of fourth and fifth grades living in Shengyang city (620 children), China and in Okayama city (579 children), Japan to determine defferences in the degree of obesity and life styles between the children of the two countries. Children whose body mass index (BMI) was 22 or higher were considered obese. The percentate of obese children was 5.7 in Shengyang and 5.4 in Okayama. Multiple logistic regression analysis of dietary patterns and life styles to explain childhood obesity in both countries showed the importance of consuming large amounts of grain products, potatoes, sugar, and oily foods as factors related to chilihood obesity. Physical activity has also been shown to be negatively and significantly associated with childhood obesity. Daily intake of enetgy, carbohydrate, and fat among obese children was significantly greater than those among nonobese children. The length of time spent watching television among the Japanese children was found to contribute to childhood obesity.
en-copyright=
kn-copyright=

en-aut-name=WangZhuan
en-aut-sei=Wang
en-aut-mei=Zhuan
kn-aut-name=王専
kn-aut-sei=王
kn-aut-mei=専
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学講座
en-keyword=児童肥満
kn-keyword=児童肥満
en-keyword=体格指数　（BMI）
kn-keyword=体格指数　（BMI）
en-keyword=生活習慣
kn-keyword=生活習慣
en-keyword=日中比較
kn-keyword=日中比較
END

start-ver=1.4
cd-journal=joma
no-vol=112
cd-vols=
no-issue=3-8
article-no=
start-page=29
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20000831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=MRI of the knee before and after arthroscopic synovectomy in patients with rheumatoid arthritis
kn-title=鏡視下滑膜切除術を行った慢性関節リウマチの膝MRI
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effectiveness of arthroscopic synovectomy (A-S) for the knee of rheumatoid arthritis (RA) patients was assesssd by comparing the severity of synovial proliferation on MRI before and after the surgery. Twenty-five patients (30 knees) were studied. The mean duration of RA was 6 years and 7 months and the mean age at the time of A-S was 49.0 years. The mean follow-up period was 19 months (range:6-39 months). The preoperative Larsen's classification from grade Ⅰto Ⅳ was 8, 13, 6, and 3 knees, resectively. Synovial proliferation was evaluated by the modified Takeuchi's classification (MRI score). The MRI score was investigated in relationships with the radiographic grade, wet weight of excised tissue, treatment score for RA knees of the Japanese Orthopaedic Association (JOA score), and the CRP value. The MRI score, JOA score, and CRP all significantly improved during follow-up. The radiographic grade showed less progression, the JOA score improved more, and CRP was lower during follow-up in patients with a postoperative MRI score less than 5. The wet weight of excised tissue showed no related with the MRI score. These results suggest that the effectiveness of A-S can be determined by evaluation of improvement of the MRI score.
en-copyright=
kn-copyright=

en-aut-name=KatohYasuyuki
en-aut-sei=Katoh
en-aut-mei=Yasuyuki
kn-aut-name=加藤泰之
kn-aut-sei=加藤
kn-aut-mei=泰之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部整形外科学講座
en-keyword=Rheumatoid arthritis
kn-keyword=Rheumatoid arthritis
en-keyword=Knee
kn-keyword=Knee
en-keyword=Arthroscopic synovectomy
kn-keyword=Arthroscopic synovectomy
en-keyword=Magnetic resonance imaging
kn-keyword=Magnetic resonance imaging
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ポリエチレンイミンカチオン化を用いたタンパク質細胞内導入技術の開発と細胞機能の人工制御への応用
kn-title=Development of a protein transduction technology using polyethylenimine-cationization, and application to regulation of cellular function
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataHitoshi
en-aut-sei=Murata
en-aut-mei=Hitoshi
kn-aut-name=村田等
kn-aut-sei=村田
kn-aut-mei=等
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=脂肪肝マウスの肝切除後の再生障害のメカニズム
kn-title=Mechanism of impaired regeneration of fatty liver in mouse partial hepatectomy model
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataHiroshi
en-aut-sei=Murata
en-aut-mei=Hiroshi
kn-aut-name=村田宏
kn-aut-sei=村田
kn-aut-mei=宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=
article-no=
start-page=11
end-page=13
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2004
dt-pub=20040701
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ウンシュウミカンにおける特殊肥料の施用効果の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=桑木信輔
kn-aut-sei=桑木
kn-aut-mei=信輔
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=大平猪一朗
kn-aut-sei=大平
kn-aut-mei=猪一朗
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=高畑真澄
kn-aut-sei=高畑
kn-aut-mei=真澄
aut-affil-num=3
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=村田芳行
kn-aut-sei=村田
kn-aut-mei=芳行
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=多田幹郎
kn-aut-sei=多田
kn-aut-mei=幹郎
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=株式会社バイオバンク

affil-num=4
en-affil=
kn-affil=岡山大学

affil-num=5
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=1
article-no=
start-page=119
end-page=125
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=20020322
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Upconversion property and light scattering in Tm(3+)-doped glass-ceramics
kn-title=Tm(3+)含有結晶化ガラスのアップコンバージョン特性と光散乱
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Glass-ceramics containing Pb(x)Cd(1-x)F(2) microcrystallites were prepared through heat treatment of Tm(3+)/Yb(3+)doped SiO(2)-Al(2)O(3)-PbF(2) glasses. The crystallite size was controlled by varying the heat-treatment time. By changing glass composition, two types of strong optical scattering, Rayleigh and Mie scattering modes were observed for the glass ceramics. In the case of Rayleigh scattering, the scattering region expanded to the long-wavelength side with increasing the heat-treatment time. On the other hand, in the case of Mie scattering, the region were hardly dependent on wavelength, and visible light was widely scattered. It was argued that the different scattering phenomena were caused by the different size of the crystallites or their morphogical texture. Furthermore, the glass-ceramics with strong optical scattering showed higher upconversion fluorescence intensity than the matrix glass. The mechanisms for the enhanced upconversion due to the scattering were discussed.
en-copyright=
kn-copyright=

en-aut-name=MiuraYoshinari
en-aut-sei=Miura
en-aut-mei=Yoshinari
kn-aut-name=三浦嘉也
kn-aut-sei=三浦
kn-aut-mei=嘉也
aut-affil-num=1
ORCID=

en-aut-name=DingYong
en-aut-sei=Ding
en-aut-mei=Yong
kn-aut-name=丁勇
kn-aut-sei=丁
kn-aut-mei=勇
aut-affil-num=2
ORCID=

en-aut-name=MurataTakashi
en-aut-sei=Murata
en-aut-mei=Takashi
kn-aut-name=村田隆
kn-aut-sei=村田
kn-aut-mei=隆
aut-affil-num=3
ORCID=

en-aut-name=HimeiYusuke
en-aut-sei=Himei
en-aut-mei=Yusuke
kn-aut-name=姫井裕助
kn-aut-sei=姫井
kn-aut-mei=裕助
aut-affil-num=4
ORCID=

en-aut-name=NanbaTokuro
en-aut-sei=Nanba
en-aut-mei=Tokuro
kn-aut-name=難波徳郎
kn-aut-sei=難波
kn-aut-mei=徳郎
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学

affil-num=5
en-affil=
kn-affil=岡山大学
en-keyword=Optical scattering
kn-keyword=Optical scattering
en-keyword=Glass-ceramics
kn-keyword=Glass-ceramics
en-keyword=Oxyfluoride glass
kn-keyword=Oxyfluoride glass
en-keyword=Microcrystallite
kn-keyword=Microcrystallite
en-keyword=Upconversion fluorescence
kn-keyword=Upconversion fluorescence
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=1
article-no=
start-page=53
end-page=64
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1999
dt-pub=1999
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ライムギ小型染色体を保持する普通系コムギからのライムギ型cDNAのディファレンシャルスクリーニング
kn-title=Differential Screening of Rye-type cDNAs from a Common Wheat Carrying the Rye Midget Chromosomes
en-subtitle=
kn-subtitle=
en-abstract=ライムギの細胞質を有する普通系コムギ(cereale)-Chinese Spring (CS)には、「ミジェット」と呼ばれる非常に小型の染色体が存在する。この染色体が失われると、その種子は胚乳が退化して発芽出来ない。かりに発芽しても、その植物は虚弱で不稔となる。このことは、この染色体にライムギ細胞質の機能維持に不可欠な遺伝子が座乗していることを示唆している。本研究では、ディファレンシャルスクリーニング法により、このミジェット染色体に座乗している遺伝子の同定を試みた。(cereale)-CSの若苗からcDNAライブラリーを作成し、約20,000のプラークをスクリーニングした。その結果、ライムギのcDNAには強くハイブリダイズするが、CSのcDNAには弱くハイブリダイズするクローンが27得られた。これらについてその特異性をサザンハイブリダイゼイション等で解析したところ、19個のクローン(
CrClAなど) はサイズ、制限酵素部位に違いは認められるもののお互いにハイブリダイズすることから、同じクラスⅠに分類された。これらは、正常CSと(cereale)-CSとの間でRELP（制限酵素断片長多型）を示し、その型はライムギと同様であった。このcDNAの塩基配列は、コムギ葉緑体DNA遺伝子rbcLに類似しており、ライムギの葉緑体DNAに由来していると考えられた。他のクローンは、コムギの核遺伝子cabとrbcにその塩基配列が類似していたが、はっきりとした多型は検出されなかった。ここで用いた方法では、光合成に関連した発現量の多いcDNAがスクリーニングされやすい傾向があり、効率的なスクリーニングには均一化したcDNAを用いる必要があると思われる。
kn-abstract=Occurrence of the midget chromosome in a common wheat with rye cytoplasm [(cereale)-Chinese Spring (CS)] indicates that the chromosome carries the essential gene(s) for maintaining the function of rye cytoplasm. To elucidate the interaction between the midget chromosome and rye cytoplasm, in this study, an attempt was made to isolate rye-type cDNAs from a cDNA library of (cereale)-CS by differential screening. Two replica filters from each plate were hybridized with digoxigenin (DIG)-labeled wheat CS cDNAs and with DIG-labeled rye cDNAs,respectively. Out of ca. 20,000 plaques, 27 were hybridized more strongly with rye cDNAs than with CS cDNAs. These clones were classified into six classes (Ⅰ-Ⅵ) by blot hybridization. The majority of the clones (21 out of 27) was belonged to the same class (1), showing rye-type RFLP (restriction fragment length polymorphism). The DNA sequence of clone CrClA in class Ⅰ, was very similar to that of wheat ribulose 1,5-bisphosphate carboxylase,large subnit gene, rbcL(94.5% homology). However, the 3' end of CrClA was shorter than that of wheat rbcL, and terminated at TAA instead of TAG, like the rbcL of Aegilops crassa. In the clone CrC5.4, the first half of the sequence was similar to that of one rice EST clone, the functions of which are not known, and the latter was similar to the reverse sequence of maize 4.5S-23S ribosomal RNA. This suggests that CrC5.4 had been derived from two defferent cDNAs of (cereale)-CS. Three other clones had homology to the chlorophyll a/b binding protein genes (cab) of wheat, maize and tomato, and one to wheat rbcS (ribulose1,5-bisphosphate carboxylase small subnit gene). However, no clear polymorphisms were detected between wheat and rye by using those clones as probes.
en-copyright=
kn-copyright=

en-aut-name=MurataMinoru
en-aut-sei=Murata
en-aut-mei=Minoru
kn-aut-name=村田稔
kn-aut-sei=村田
kn-aut-mei=稔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
en-keyword=Cytoplasm substitution line
kn-keyword=Cytoplasm substitution line
en-keyword=Differential screening
kn-keyword=Differential screening
en-keyword=Midget chromosome
kn-keyword=Midget chromosome
en-keyword=Rye
kn-keyword=Rye
en-keyword=Wheat
kn-keyword=Wheat
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=1
article-no=
start-page=49
end-page=58
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=1996
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=幼苗期と成熟期のオオムギ系統間における禾穀類アブラムシの密度とグラミン含量の関係
kn-title=Relationship between Gramine Concentration and Cereal Aphid Polulations in Seedling and Maturation Stages in Barley Lines
en-subtitle=
kn-subtitle=
en-abstract=オオムギ（Hordeum spontaneum及びH.vulgare）14系統の幼苗期と成熟期における、アブラムシの密度とインドールアルカロイド化合物であるグラミン含量の関係を調べた。温室内の幼苗では、グラミン含量に関わらずムギミドリアブラムシ（Schizaphis graminum）の寄生密度に有意差は認められなかった。一方、ムギクビレアブラムシ（Rhopalosiphum padi）の密度は、幼苗間で異なる場合もあった。圃場におけるアブラムシの寄生に対して、抵抗性は出穂期に顕著に現れた。アブラムシの寄生密度とグラミン含量の間には負の相関が認められた。成熟期のオオムギでは、グラミンの分解活性の高い感受性系統と比較して、抵抗性系統のグラミン含量は多く、特に野生系統では著しかった。
kn-abstract=The relationship between the indole alkaloid gramine concentration and aphid population was examined seedling and maturation stages in 14 barley lines of Hordeum spontaneum and H. unlgare. The density of Schizaphis graminum did not differ significantly with the gramine concentration in the seedling in the greenhouse. However, the population of Rhopalosiphum padi sometimes differed with the seedling. The plant resistance to the natural infestation of cereal aphids was obvious at the heading stage. There was a negative correlation between the high population density of aphids and gramine concentration. The gramine concentration was high in matured resistant resistant lines, especially wild lines, as compared with susceptible lines due to higher biodegradation activity.
en-copyright=
kn-copyright=

en-aut-name=MoharramipourSaeid
en-aut-sei=Moharramipour
en-aut-mei=Saeid
kn-aut-name=MoharramipourSaeid
kn-aut-sei=Moharramipour
kn-aut-mei=Saeid
aut-affil-num=1
ORCID=

en-aut-name=MurataShin-ichi
en-aut-sei=Murata
en-aut-mei=Shin-ichi
kn-aut-name=村田眞一
kn-aut-sei=村田
kn-aut-mei=眞一
aut-affil-num=2
ORCID=

en-aut-name=KanehisaKatsuo
en-aut-sei=Kanehisa
en-aut-mei=Katsuo
kn-aut-name=兼久勝夫
kn-aut-sei=兼久
kn-aut-mei=勝夫
aut-affil-num=3
ORCID=

en-aut-name=TsumukiHisaaki
en-aut-sei=Tsumuki
en-aut-mei=Hisaaki
kn-aut-name=積木久明
kn-aut-sei=積木
kn-aut-mei=久明
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
en-keyword=Barley
kn-keyword=Barley
en-keyword=Resistance
kn-keyword=Resistance
en-keyword=Gramine
kn-keyword=Gramine
en-keyword=Cereal aphids
kn-keyword=Cereal aphids
END

start-ver=1.4
cd-journal=joma
no-vol=84
cd-vols=
no-issue=1
article-no=
start-page=73
end-page=76
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19950201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Role of Plasma Membrane K+ Channels in Salt Adaptation of Tabacco Suspension Cells
kn-title=タバコ培養細胞の塩ストレス適応機構における原形質膜カリウムチャンネルの役割
en-subtitle=
kn-subtitle=
en-abstract=一般に、高等植物は塩に弱く、土壌の塩の集積によって、生育が困難になり、枯死に至る。しかし、塩に強い、あるいは、塩を好む高等植物も存在している。これらの植物の耐塩性あるいは塩ストレス適応機構の解明は、塩ストレス適応植物または耐塩性植物作出のための基礎的知見を与える。高等植物にとって塩ストレスは、ナトリウムによる代謝阻害を意味する。《イオンストレス》と、水分の吸収に関わる《浸透圧ストレス》とに大別される。これまでの研究によって、塩ストレスの主たる原因は、《イオンストレス》であることが知られるようになった。また、塩生植物も含め高等植物は塩に強い酵素を持たないため、細胞質中の高いカリウムイオンとナトリウムイオンとの比（K+/Na+）の維持が塩ストレス適応機構および耐塩性機構にふかく関わっていることも明らかにされつつある。しかし、細胞質中の高K+やNa+の主な流出入の経路と考えられる原形質膜のイオンチャンネルの役割については、ほどんど明らかにされていない。また、塩ストレスの初期の段階でNa+によって原形質膜表面のCa2+が置換されることや細胞外のCa2+の減少によってK+の流出が起きること、細胞外のCa2+によって塩ストレスが軽減されることなど、Ca2+が塩ストレスの初期の段階で重要な動きをしていることが示唆されている。しかし、そのCa2+の制御機構についても、詳細は明らかにされていない。本研究では、高等植物の細胞レベルでの研究に適しているタバコ培養細胞（BY-2）を材料として、また電気生理学的手法（パッチクランプ法、細胞電気泳動法、本研究で確立した蛍光プローブによる定量的膜電位測定法）を用いて、高等植物の塩ストレス適応機構における原形質膜のK+チャンネルの役割の解明、塩ストレス適応機構における細胞内外および表面のCa2+の役割の解明を行なった。
kn-abstract=The fluorescent probe method was applied to determine the membrane potential of tobacco (Nicotiana tabacum L. cv Bright Yellow) cells that were either unadapted (NaCl-unadapted cells) or adapted to 50 mM NaCl (Na50-adapted cells). There were no deffrences in the bahavior of the membrane potential between the NaCl-unadapted cells and the Na50-adapted cells. The patch-cpamp technique was used to study and compare the characterristics of cation channels in the plasma membrance of NaCl-unadapted cells, Na50-adapted and Na100-adapted cells. The steady-state amplitude of the outward whole-cell currents decreased in the following order; NaCl-unadapted cells>Na50-adapted cells>Na100-adapted cells. There were no significant differences between the NaCl-unadapted cells and the Na50-adapted cells in terms of the K+/Na+ selectivity of these channels. These observations suggest that adaptation to salinity in reduced permeability of the K+ channels to both K+ and Na+. K+ channels in the plasma membrane were investigated using the patch-clamp technique. The outward rectifying whole-cell currents were reduced with increasing extracellular Ca2+ and were independent of intracellular Ca2+. The K+/Na+ selectivity were independent of Ca2+ concentration. These observations suggest that extracellular Ca2+ is an important factor in the regulation of ion permeability. The characteristics of Ca2+ binding on the plasma membrane were investigated by the micro-electrophoresis tecniqui. Comparison of the amount of Ca2+ bound in the presence of 30 mM NaCl with that in the presence of 30 mM KCl indicated that Na+ reduced the amount of Ca2+ bound to the plasma membrane of the NaCl-unadapted cells,but did not reduce the amount of Ca2+ bound to the plasma membrane of the Na50-adapted cells. These results suggest that adaptation to salt sterss results in increased resisrtance to the displecement of membrane-associated Ca2+ by Na+.
en-copyright=
kn-copyright=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=村田芳行
kn-aut-sei=村田
kn-aut-mei=芳行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
en-keyword=ion channel
kn-keyword=ion channel
en-keyword=salt stress
kn-keyword=salt stress
en-keyword=patch clamp
kn-keyword=patch clamp
en-keyword=calcium
kn-keyword=calcium
en-keyword=Nicotiana tobacum
kn-keyword=Nicotiana tobacum
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=1
article-no=
start-page=85
end-page=90
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=199802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Photodecomposition of Ergosterol by Near-UV irradiation in the Plasma Membrane of the Yeast Rhodotorula minuta
kn-title=長波長紫外光照射による酵母 Rhodotorula minuta 細胞膜エルゴステロールの分解
en-subtitle=
kn-subtitle=
en-abstract=酵母Rhodotorula minutaにおけるカロテノイドの光誘導合成および細胞膜の機能損傷に関わる初期光化学反応についての知見を得る目的で、長波長紫外光(UV-A光)による細胞膜エルゴステロールの分解を調べ、次の結果を得た。酵母菌体および菌体から調製した細胞膜調製品に長波長紫外光を照射すると吸収スペクトルに微細な変化が生じることを認めた。細胞膜調製品に生じた吸収スペクトルの変化は細胞膜エルゴステロールが光化学分解を受けることを予想させ、この予想はHPLC分析によって確かめられた。また、モデル系での実験によって、細胞膜中のエルゴステロールの光化学反応には特別な光受容体あるいは光増感剤は介在しておらず、エルゴステロール自身が光受容体であり反応基質となっていることが明らかになった。
kn-abstract=In search for primary photochemical reaction related to photoinduced carotenogenesis and photoinactivivation in yeast Rhodotorula minuta, the influence of near-UV radiation (300-400 nm) on ergosterol in the plasma membrane of the yeast. Irradiation by near-UV of intact cells and the plasma membrane preparation from the yeast caused changes in their absorption spectra. For the plasma membrane, difference spectra measured after irradiation of near-UV suggested the decomposition of ergosterol and the suggestion was proved by HPLC analysis. Experiments in model systems revealed that ergosterol itself was the photoreceptor in the photochemical reaction, and that there was not any other photoreceptor or photosensitizer which was related to photochemical reaction of ergosterol decomposition in the plasma membrane.
en-copyright=
kn-copyright=

en-aut-name=NakaumaMakoto
en-aut-sei=Nakauma
en-aut-mei=Makoto
kn-aut-name=中馬誠
kn-aut-sei=中馬
kn-aut-mei=誠
aut-affil-num=1
ORCID=

en-aut-name=AramiShin-ichiro
en-aut-sei=Arami
en-aut-mei=Shin-ichiro
kn-aut-name=荒見真一郎
kn-aut-sei=荒見
kn-aut-mei=真一郎
aut-affil-num=2
ORCID=

en-aut-name=HadaMegumi
en-aut-sei=Hada
en-aut-mei=Megumi
kn-aut-name=秦恵
kn-aut-sei=秦
kn-aut-mei=恵
aut-affil-num=3
ORCID=

en-aut-name=NakagawaIchiro
en-aut-sei=Nakagawa
en-aut-mei=Ichiro
kn-aut-name=中川一郎
kn-aut-sei=中川
kn-aut-mei=一郎
aut-affil-num=4
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=村田芳行
kn-aut-sei=村田
kn-aut-mei=芳行
aut-affil-num=5
ORCID=

en-aut-name=TadaMikiro
en-aut-sei=Tada
en-aut-mei=Mikiro
kn-aut-name=多田幹郎
kn-aut-sei=多田
kn-aut-mei=幹郎
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=農林水産省食品総合研究所

affil-num=3
en-affil=
kn-affil=神戸大学理学部

affil-num=4
en-affil=
kn-affil=九州農政局

affil-num=5
en-affil=
kn-affil=岡山大学

affil-num=6
en-affil=
kn-affil=岡山大学
en-keyword=Rhodotorula minuta
kn-keyword=Rhodotorula minuta
en-keyword=near-UV
kn-keyword=near-UV
en-keyword=ergosterol
kn-keyword=ergosterol
en-keyword=absorbance change
kn-keyword=absorbance change
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=1
article-no=
start-page=45
end-page=51
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=200002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Photochemical Products from Ergosterol in the Plasma Membrane of the Yeast Rhodotorula minuta cells illuminated by Near-UV
kn-title=長波長紫外光によって酵母 Rhodotorula minuta 細胞膜に生じるエルゴステロールの光化学反応生成物
en-subtitle=
kn-subtitle=
en-abstract=赤色酵母R.minuta細胞膜に長波長紫外光を照射した時に生じるエルゴステロール由来の光化学反応生成物の単離・精製およびその同定を行った。結果、3種類の物質が単離・精製され、そのうち1つはPrevitamin D2であることが同定され、残りの2つについてはergosta-4,7,22-trien-3-on の何かの炭素にOH基が付いたものであることが分かった。単離した成分を培地に加え、菌体の増殖とカロテノイド生合成に対する影響を調べた結果、これらの物質はそのどちらにも影響を及ぼさなかった。
kn-abstract=When the plasma mumbrane of the yeast Rhodotorula minuta cells was exposed to near-UV at 0℃, three new compounds were formes photochemically with decrease in ergosterol content. When 0.4%-SDS solution containing ergosterol was illuminated with near-UV, the same three compounds as in the membrane were formed. As a result of instruments analysis, one of three photochemical products was identified as previtamine D2 and another two compounds were characterized chemically that they had the structure of ergosta-4, 7, 22-trein-3-on. In addition, these photochemical products did not affect the growth and carotenogenesis of the yeast Rhodotorulaminuta.
en-copyright=
kn-copyright=

en-aut-name=NakaumaMakoto
en-aut-sei=Nakauma
en-aut-mei=Makoto
kn-aut-name=中馬誠
kn-aut-sei=中馬
kn-aut-mei=誠
aut-affil-num=1
ORCID=

en-aut-name=IriyamaTakuya
en-aut-sei=Iriyama
en-aut-mei=Takuya
kn-aut-name=入山卓也
kn-aut-sei=入山
kn-aut-mei=卓也
aut-affil-num=2
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=村田芳行
kn-aut-sei=村田
kn-aut-mei=芳行
aut-affil-num=3
ORCID=

en-aut-name=TadaMikiro
en-aut-sei=Tada
en-aut-mei=Mikiro
kn-aut-name=多田幹郎
kn-aut-sei=多田
kn-aut-mei=幹郎
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学
en-keyword=Rhodotorula minuta
kn-keyword=Rhodotorula minuta
en-keyword=near-UV
kn-keyword=near-UV
en-keyword=ergosterol
kn-keyword=ergosterol
en-keyword=photochemical products
kn-keyword=photochemical products
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=20000325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ウシグソヒトヨタケにおける性形態形成の遺伝学的及び分子生物学的解析
kn-title=Genetic and Molecular Analyses of Sexual Morphogenesis in Coprinus cinereus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=村田幸男
kn-aut-sei=村田
kn-aut-mei=幸男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1970
dt-pub=19700930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ヒトの骨格筋線維分化に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=村田文雄
kn-aut-sei=村田
kn-aut-mei=文雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1997
dt-pub=19970325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=拡張型心筋症におけるI-MIBGシンチグラフｨーと心内膜下心筋生検組織所見の対比検討
kn-title=Relation of Iodine-1'23 Metaiodobenzy lguanidine Myocardial Scintigraphy to Endomyocardial Biopsy Findings in Patients with Dilated Cardiomyopathy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=村田克敏
kn-aut-sei=村田
kn-aut-mei=克敏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1967
dt-pub=19670930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=制癌剤の副作用防止に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=村田雅彦
kn-aut-sei=村田
kn-aut-mei=雅彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END