膠原病の肺病変に関する研究 第2編 全身性エリテマトーデスにおける肺病変についての臨床的研究

全身性エリエマトーデス(SLE)の肺病変についてはRakov&Taylorらの報告(1))以来,多くの報告がある(2)3)).1971年にARAの診断基準が発表されて以来,SLEの診断はほぼ世界的に統一された.それ以前のSLEの肺病変の報告,集計はSLEの診断基準が少しあいまいであり,これらの報告をもって今日論ずることはやや難があると考えられる.またSLEの治療が副腎皮質ステロイド剤によって画期的に進歩した今日,もう一度SLEの肺病変について検討を加えることは,充分に意義のあることと考えられる.本論文では, SLEの肺病変を胸部レントゲン的にとらえた上に,種々の臨床的検討を加えた.

Pulmonary lesions of systemic lupus erythematosus (SLE) were examined using chest X-ray film and studied clinically from various lines of investigation. 1) As intrathoracic lesions of SLE, there were 7 pleurisy cases (10% ), 18 pulmonary fibrosis cases (24% ), 6 pneumonia cases (8% ), 2 pulmonary mycosis cases (3% ) and 2 pulmonary tuberculosis cases (3% ). 2) A streaky pattern of the chest X-ray film in pulmonary fibrosis of SLE was most common with nodular, reticular and cystic pattern occurring seldom. 3) The distribution of pulmonary fibrosis of SLE was predominant in the middlelower lung field. 4) Pulmonary fibrosis of SLE did not correlate with antinuclear antibody, rheumatic facter, anti-DNA antibody, anti-lung antibody, serum complement titer and renal involvement. 5) The pulmonary lesions of SLE were compared with those of other collagen diseases(PSS, RA, PM-DM). Pleural lesions and pulmonary infections were observed in many cases while pulmonary fibrosis was seldom obseved and mild when obseved.