result 24389 件
| Author | Komatsu, Seiji| Nagai, Yusuke| Naruse, Keiji| Kimata, Yoshihiro| |
|---|---|
| Published Date | 2014-07-21 |
| Publication Title | PLoS ONE |
| Volume | volume9 |
| Issue | issue7 |
| Content Type | Journal Article |
| Author | Fujii, K| Kurozumi, K| Ichikawa, T| Onishi, M| Shimazu, Y| Ishida, J| Chiocca, EA| Kaur, B| Date, I| |
|---|---|
| Published Date | 2013-08 |
| Publication Title | Cancer Gene Therapy |
| Volume | volume20 |
| Issue | issue8 |
| Content Type | Journal Article |
| Author | Hirai, Misato| Maeda, Yukihide| Fukushima, Kunihiro| Sugaya, Akiko| Kataoka, Yuko| Nishizaki, Kazunori| |
|---|---|
| Published Date | 2011-09-14 |
| Publication Title | NeuroReport |
| Volume | volume22 |
| Issue | issue13 |
| Content Type | Journal Article |
| Author | Itami, Hisakazu| Tokunaga, Koji| Okuma, Yu| Hishikawa, Tomohito| Sugiu, Kenji| Ida, Kentaro| Date, Isao| |
|---|---|
| Published Date | 2013-09 |
| Publication Title | Neuroradiology |
| Volume | volume55 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Yano, Shuya| Tazawa, Hiroshi| Hashimoto, Yuuri| Shirakawa, Yasuhiro| Kuroda, Shinji| Nishizaki, Masahiko| Kishimoto, Hiroyuki| Uno, Futoshi| Nagasaka, Takeshi| Urata, Yasuo| Kagawa, Shunsuke| Hoffman, Robert M.| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2013-12-01 |
| Publication Title | Clinical Cancer Research |
| Volume | volume19 |
| Issue | issue23 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52789 |
|---|---|
| FullText URL | 68_4_235.pdf |
| Author | Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi| |
| Abstract | The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice. |
| Keywords | microalbuminuria type 2 diabetes mellitus remission regression |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 235 |
| End Page | 241 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145409 |
| Web of Science KeyUT | 000340687500005 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52828 |
| JaLCDOI | 10.18926/AMO/52788 |
|---|---|
| FullText URL | 68_4_219.pdf |
| Author | Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi| |
| Abstract | Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2. |
| Keywords | chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145408 |
| Web of Science KeyUT | 000340687500004 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52824 |
| JaLCDOI | 10.18926/AMO/52787 |
|---|---|
| FullText URL | 68_4_207.pdf |
| Author | Yu, Liling| Kato, Yutaka| Shishido, Keisuke| Doi, Hideko| Jin, Haeng mi| Wang, Jin gang| Ikezawa, Junko| Awaya, Tsuyoshi| |
| Abstract | This study examines the attitudes of young Japanese, Chinese, and South Koreans toward birth and child-rearing. The survey targeted four-year university students (n＝1,668) who responded to an anonymous survey using self-report questionnaires between December 2012 and April 2013. The collection rates were 72.5%, 94.7%, and 96.5% for the Japanese, Chinese, and South Korean students, respectively. Correlations among the respondentsʼ attributes, medical and scientific literacy levels, and views of preferred qualities of children were analyzed using chi-square test, supplemented by residual analysis (significance level set at p＜0.05). Participants were asked whether they were willing to use the following methods for obtaining preferred qualities in their children:(1) choosing a spouse (43.2%, 72.6%, and 85.1% of the Japanese, Chinese, and South Koreans, respectively, agreed);(2) using a sperm bank (cryobank) (5.8%, 60.1%, and 81.7% of the Japanese, Chines, and South Koreans, respectively, agreed);and (3) using an egg cell bank (ova bank or cryobank) (5.3%, 47.2%, and 70.3% of the Japanese, Chinese, and South Koreans, respectively, agreed). The proportion of affirmative responses (indicating “eugenic inclination”) to these statements was significantly higher among the Chinese and South Korean participants than their Japanese counterparts (p＜0.001). Significant differences were also found in the attitudes of the 3 groups toward methods for obtaining the preferred qualities for their children:prenatal diagnosis, pre-implantation diagnosis, the environment during pregnancy, and child-rearing. |
| Keywords | prenatal diagnosis pre-implantation diagnosis delivery and child-rearing eugenics healthy birth and child-rearing |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 207 |
| End Page | 218 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145407 |
| Web of Science KeyUT | 000340687500003 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52823 |
| JaLCDOI | 10.18926/AMO/52786 |
|---|---|
| FullText URL | 68_4_201.pdf |
| Author | Endo, Hirosuke| Akazawa, Hirofumi| Mitani, Shigeru| Okada, Yoshiki| Yamane, Kentaro| Ozaki, Toshifumi| |
| Abstract | We reviewed the treatment outcome in 14 hips of 7 patients who were diagnosed as having bilateral developmental dislocation of the hip (DDH) after walking age and could be followed up until they were at least 14 years of age. Based on the results of two-directional arthrography of the hip, closed reduction was performed in 2 hips, and open reduction was performed without osteotomy in 12 hips. The final radiographic evaluations were made according to the Kalamchi and MacEwen classification and Severin classification. The mean age at the initial visit was 1 year and 9 months (range, 1 year and 5 months to 3 years). The outcome was satisfactory for one hip in Group Ⅰ and 2 hips in Group Ⅱ according to the Kalamchi and MacEwen classification, and in 83% of the Severin Class Ⅰ and Ⅱ hips. Arthrography was useful for identifying asymmetry, demonstrating the usefulness of a treatment strategy based on arthrography of the hip. |
| Keywords | developmental dislocation of the hip bilateral case arthrogram open reduction after walking age |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 201 |
| End Page | 206 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145406 |
| Web of Science KeyUT | 000340687500002 |
| JaLCDOI | 10.18926/AMO/52785 |
|---|---|
| FullText URL | 68_4_191.pdf |
| Author | Shien, Kazuhiko| Yamamoto, Hiromasa| Soh, Junichi| Miyoshi, Shinichiro| Toyooka, Shinichi| |
| Abstract | Non-small cell lung cancer (NSCLC) harboring an activating mutation within the epidermal growth factor receptor (EGFR) was defined as a clinically distinct molecular group. These lesions show oncogene addiction to EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). Several large Phase III trials have shown that EGFR-TKIs improved the progression-free survival of patients with EGFR mutant NSCLC compared to conventional chemotherapy. However, the long-term effectiveness of EGFR-TKIs is usually limited because of acquired drug resistance. To overcome this resistance to EGFR-TKIs, it will be essential to identify the specific mechanisms underlying the resistance. Many investigators have attempted to identify the mechanisms using preclinical models and drug-resistant clinical samples. As a result, several mechanisms have been showed to be responsible for the resistance, but not all of the relevant mechanisms have been uncovered. In this review, we provide an overview of mechanisms underlying drug-resistance to EGFR-TKIs, focusing on results obtained with preclinical models, and we present some possible strategies to overcome the EGFR-TKI resistance. |
| Keywords | non-small cell lung cancer EGFR mutation tyrosine-kinase inhibitor drug resistance cancer stem cell |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 191 |
| End Page | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145405 |
| Web of Science KeyUT | 000340687500001 |
| Author | Hayakawa, Hiromi| Ichihara, Eiki| Ohashi, Kadoaki| Ninomiya, Takashi| Yasugi, Masayuki| Takata, Saburo| Sakai, Katsuya| Matsumoto, Kunio| Takigawa, Nagio| Tanimoto, Mitsune| Kiura, Katsuyuki| |
|---|---|
| Published Date | 2013-11 |
| Publication Title | Cancer Science |
| Volume | volume104 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Kurahashi, Hiroaki| Watanabe, Masami| Sugimoto, Morito| Ariyoshi, Yuichi| Mahmood, Sabina| Araki, Motoo| Ishii, Kazushi| Nasu, Yasutomo| Nagai, Atsushi| Kumon, Hiromi| |
|---|---|
| Published Date | 2013-12 |
| Publication Title | Endocrine Journal |
| Volume | volume60 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Hayashi, Tatsuro| Asano, Hiroaki| Toyooka, Shinichi| Tsukuda, Kazunori| Soh, Junichi| Shien, Tadahiko| Taira, Naruto| Maki, Yuho| Tanaka, Norimitsu| Doihara, Hiroyoshi| Nasu, Yasutomo| Huh, Nam-ho| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-05 |
| Publication Title | Journal of Cancer Research and Clinical Oncology |
| Volume | volume138 |
| Issue | issue5 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/bgeou/52778 |
|---|---|
| FullText URL | bgeou_156_033_038.pdf |
| Author | Seta, Yukito| Jiang, Fan| |
| Abstract | The present study addresses the question how Go for it!, a textbook developed on task-based language instruction mode, treats language forms. Tasks and activities from a sample unit in Go for it! are analyzed to examine whether and how textbook writers incorporate a Focus on Form in the task and activity design. The results show that equal emphasis is laid on both meaning and form, and three major types of Focus on Form tasks and two types of Focus on Form activities are identified. The study may contribute to textbook designers and teachers in treating the issue of how to design Focus on Form activities in task-based language teaching. |
| Keywords | meaning form focus on form task-based teaching |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-07-28 |
| Volume | volume156 |
| Start Page | 33 |
| End Page | 38 |
| ISSN | 1883-2423 |
| language | English |
| File Version | publisher |
| NAID | 120005464806 |
| JaLCDOI | 10.18926/bgeou/52777 |
|---|---|
| Title Alternative | Developing the Outline of a Document Explaining the Necessity of Effective Educational Goals to Private Kindergartens’ Staff Members |
| FullText URL | bgeou_156_023_031.pdf |
| Author | Yokomatsu, Tomoyoshi| |
| Abstract | わが国の幼稚園教育において，カリキュラムマネジメントをさらに発展させていくために は，幼稚園現場の職員に対する，実効のある保育目標明確化の必要性が理解できる説明資料 を開発することが不可欠であるといえる。そこで，本研究では，その最初の段階として，私 立幼稚園職員を対象に，その過半数にそのことが理解できる説明資料の概要をアクション・ リサーチにより開発している。その概要に含まれる項目は，各幼稚園において実効のある保 育目標明確化の必要性が生じた政策的背景，幼稚園の保育目標にかかわる法的規定，これま でに開発されている実効のある保育目標の明確化手順，保護者が実効のある保育目標を共有 することによって保育についての共通理解と子育てへの意欲が促される可能性，保育者が実 効のある保育目標を共有することによって保育についての共通理解と意欲とが促される可能 性である。 |
| Keywords | 私立幼稚園職員 実効のある保育目標明確化 必要性 説明 資料 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-07-28 |
| Volume | volume156 |
| Start Page | 23 |
| End Page | 31 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005464805 |
| JaLCDOI | 10.18926/bgeou/52776 |
|---|---|
| Title Alternative | Analyzing Peer Interactions and Teachers’ Support During Structured Play Activities in a Special Needs Education School. |
| FullText URL | bgeou_156_015_021.pdf |
| Author | Nakaya, Akitaka| Nakao, Kaho| Takeuchi, Ai| |
| Abstract | 知的障害特別支援学校小学部の「遊びの指導」の授業における児童同士のかかわりの実態 を整理し，かかわりを促す教師の具体的な支援の在り方について検討するため，実際の授業 における児童及び教師の言動を時間の流れに沿って書き出して作成したトランスクリプトを 基に整理・分析した。その結果，実態の異なる２人の対象児は共に，他の児童に対して高い 関心を示しており，その示し方は発声・発語や身体動作に比べ，注視が多かったことが確か められた。また，対象児の他の児童に対する発信の契機を調べた結果，教師よりも他の児童 の言動が契機となった場合が多く，教師が契機であった場合については，対象児の他の児童 への発信に至る過程が４パターンに分類された。さらに，児童同士のかかわりを促す教師の 具体的な支援の在り方に関する示唆を得た。 |
| Keywords | 知的障害特別支援学校 遊びの指導 授業分析 児童同士のかかわり 発信の過程 |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-07-28 |
| Volume | volume156 |
| Start Page | 15 |
| End Page | 21 |
| ISSN | 1883-2423 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005464804 |
| JaLCDOI | 10.18926/bgeou/52774 |
|---|---|
| FullText URL | bgeou_156_001_005.pdf |
| Author | Sanada, Satoshi| Higa Diez, Midory| Yamane, Daiki| Kado, Yoko| Nakano, Kousuke| Ogino, Tatsuya| |
| Abstract | The Rey - Osterrieth Complex Figure (ROCF) test assess visual-construction abilility, visual memory and executive function. Three different methods are traditionally used to track and to record the strokes during the production of the complex figure: single pen, switching felt pens and flowcharts. The Inkling™ is an instrument which attributes are to track, to record and to save the information of every stroke depicted in a standard piece of paper. The purpose of the study is to examine the advantages and disadvantages of using the Inkling™ in the ROCF test. 66 ROCF performances were analyzed from subjects aged 6 to 86 years old. Each subject performed the ROCF test twice; first with pen switching method without flowcharts and later with the Inkling™ or viceversa. The comparison of the performances evidenced 5 characteristics: Four subjects distracted by the color of the felt pens, three subjects interfered by the switching of the felt pens, three subjects which performance was facilitated by the colors of the felt pens, nine subjects with unclear score for Fragmentation and fourteen subjects with unclear score for Planning. The advantages that the Inkling™ showed were compensation for the process of flowcharts, avoid interference, and reduce the burden of unclear scoring for Fragmentation and Planning. |
| Keywords | Rey-Osterrieth Complex Figure test cognitive assessment executive function switching felt pens method Inkling™. |
| Publication Title | 岡山大学大学院教育学研究科研究集録 |
| Published Date | 2014-07-28 |
| Volume | volume156 |
| Start Page | 1 |
| End Page | 5 |
| ISSN | 1883-2423 |
| language | English |
| File Version | publisher |
| NAID | 120005464802 |
| Author | 福永 信哲| |
|---|---|
| Published Date | 2014-08-01 |
| Publication Title | Persica |
| Volume | volume41 |
| Content Type | Journal Article |
| Author | Yamaneki, Kanako| |
|---|---|
| Published Date | 2014-08-01 |
| Publication Title | Persica |
| Volume | volume41 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/OLR/52756 |
|---|---|
| Title Alternative | Case Study on Administrative Law |
| FullText URL | olr_013_135_145.pdf |
| Author | Yoshino, Natsumi| |
| Publication Title | 臨床法務研究 |
| Published Date | 2014-07 |
| Volume | volume13 |
| Start Page | 135 |
| End Page | 145 |
| ISSN | 1881-1485 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005464798 |
