過敏性肺臓炎の病態に関する研究 第1編 実験的過敏性肺臓炎における免疫学的並びに病理組織学的検討

Hypersensitivity pneumonitis is well known as an allergic respiratory disease although the exact pathogenesis is still in controversy. An experimental animal model was established with Micropolyspora faeni (Mf) as the antigen, and the various immunological mechanisms were evaluated. Transtracheal challange of Mf antigen in guinea pigs sensitized with Mf antigen showed granulomatous pneumonitis compatible with hypersensitivity pneumonitis in humans including the precipitating antibody. The cellular responses in the lungs of animal model was examined with bronchoalveolar lavage (BAL) and the increase of total cell count and lymphocyte percentage were shown to correlate with the degree of alveolitis. Lymphocytes in BAL fluid of sensitized guinea pigs were shown to repond to Mf antigen specifically. Several characteristics of hypersensitivity pneumonitis were clearly shown in this animal model. Although the actual pathogenesis in humans is still obscure. this model could be useful in the evaluation of the patients with hypersensitivity pneumonitis.

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