クロルデンのラット肝ミトコンドリアの呼吸活性に対する作用

In attempting to clarify the toxicity of chlordane, its effects on respiratory activities in hepatic mitochondria and on electron transport in sonicated submitochondrial particles were examined. State 3 and 4 respiration, and DNP-released respiration were inhibited by chlordane compounds, with the ranked degree of inhibition was in descending order being, trans-chlordane, cis-chlordane, and heptachlor. The inhibitory effects of chlordane were more remarkable in the presence of succinate as a respiratory substrate than in the presence of β-hydroxybutylate or ascorbate. Heptachlor also decreased cytochrome C reduction by NADH-cytochrome C reductase. The results suggest that chlordane does not seem to be a specific inhibitor such as cyanide, rotenone, or antimycin A.