result 47822 件
| FullText URL | K0006024_abstract_review.pdf K0006024_fulltext.pdf K0006024_other_1 figure.pdf K0006024_other_2 Supplementary figures and legends.pdf |
|---|---|
| Author | Watanabe, Shin-ichiro| |
| Published Date | 2019-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6024号 |
| Granted Date | 2019-09-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | fcell_2019_00160_p.pdf fcell_2019_00160_a.pdf |
|---|---|
| Author | Satoh, Ayano| Hayashi-Nishino, Mitsuko| Shakuno, Takuto| Masuda, Junko| Koreishi, Mayuko| Murakami, Runa| Nakamura, Yoshimasa| Nakamura, Toshiyuki| Abe-Kanoh, Naomi| Honjo, Yasuko| Malsam, Joerg| Yu, Sidney| ishino, Kunihiko | |
| Keywords | Golgi golgins glycosylation endoplasmic reticulum electron tomography |
| Published Date | 2019-08-27 |
| Publication Title | Frontiers in Cell and Developmental Biology |
| Volume | volume7 |
| Start Page | 160 |
| ISSN | 2296634X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 31544102 |
| DOI | 10.3389/fcell.2019.00160 |
| Related Url | isVersionOf https://doi.org/10.3389/fcell.2019.00160 |
| FullText URL | Biochemistry_58_26_2934.pdf |
|---|---|
| Author | Shibukawa, Atsushi| Kojima, Keiichi| Nakajima, Yu| Nishimura, Yosuke| Yoshizawa, Susumu| Sudo, Yuki| |
| Note | This fulltext will be available in Jun 2020| |
| Published Date | 2019-05-31 |
| Publication Title | Biochemistry |
| Volume | volume58 |
| Issue | issue26 |
| Publisher | American Chemical Society |
| Start Page | 2934 |
| End Page | 2943 |
| ISSN | 00062960 |
| NCID | AA00564599 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 31150215 |
| DOI | 10.1021/acs.biochem.9b00257 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.biochem.9b00257 |
| FullText URL | SciRep_9_7863.pdf |
|---|---|
| Author | Yamanashi, Taro| Maki, Misayo| Kojima, Keiichi| Shibukawa, Atsushi| Tsukamoto, Takashi| Chowdhury, Srikanta| Yamanaka, Akihiro| Takagi, Shin| Sudo, Yuki| |
| Published Date | 2019-05-27 |
| Publication Title | Scientific reports |
| Volume | volume9 |
| Issue | issue1 |
| Publisher | Nature Publishing Group |
| Start Page | 7863 |
| ISSN | 20452322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 31133660 |
| DOI | 10.1038/s41598-019-44308-x |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-44308-x |
| FullText URL | RSocOpenSci_6_5_190293_p.pdf |
|---|---|
| Author | Tani, Yumeki| Kaneta, Takashi| |
| Keywords | gold nanoparticle optical force vesicles |
| Published Date | 2019-05-15 |
| Publication Title | Royal Society Open Science |
| Volume | volume6 |
| Issue | issue5 |
| Publisher | Royal Society Publishing |
| Start Page | 190293 |
| ISSN | 20545703 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 31218066 |
| DOI | 10.1098/rsos.190293 |
| Related Url | isVersionOf https://doi.org/10.1098/rsos.190293 |
| FullText URL | AnalytMethods_2019_11_179.pdf |
|---|---|
| Author | Hashimoto, Yuki| Kaneta, Takashi| |
| Note | This fulltext will be available in Dec 2019| |
| Published Date | 2018-12-10 |
| Publication Title | Analytical Methods |
| Volume | volume11 |
| Publisher | Royal Society of Chemistry |
| Start Page | 179 |
| End Page | 184 |
| ISSN | 17599660 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1039/C8AY02298D |
| Related Url | isVersionOf https://doi.org/10.1039/C8AY02298D |
| FullText URL | ChemRec_19_2_3_452.pdf |
|---|---|
| Author | Kaneta, Takashi| |
| Keywords | DNA sequencing capillary electrophoresis laser-induced fluorescence micellar electrokinetic chromatography |
| Published Date | 2018-08-06 |
| Publication Title | Chemical Record |
| Volume | volume19 |
| Issue | issue2-3 |
| Publisher | Wiley |
| Start Page | 452 |
| End Page | 461 |
| ISSN | 15278999 |
| NCID | AA11515019 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30079538 |
| DOI | 10.1002/tcr.201800051 |
| Related Url | isVersionOf https://doi.org/10.1002/tcr.201800051 |
| FullText URL | ACS_Omega_4_12_15249_p.pdf |
|---|---|
| Author | Buking, Supatana| Suedomi, Yusuke| Nacapricha, Duangjai| Kaneta, Takashi| |
| Published Date | 2019-07-03 |
| Publication Title | ACS Omega |
| Volume | volume4 |
| Issue | issue12 |
| Publisher | American Chemical Society |
| Start Page | 15249 |
| End Page | 15254 |
| ISSN | 24701343 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 31552371 |
| DOI | 10.1021/acsomega.9b02226 |
| Related Url | isVersionOf https://doi.org/10.1021/acsomega.9b02226 |
| FullText URL | K0006023_abstract_review.pdf K0006023_summary.pdf |
|---|---|
| Author | Umeno, Junko| |
| Published Date | 2019-09-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6023号 |
| Granted Date | 2019-09-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | VirusRes_177_1_75.pdf Table 1-revised.pdf FigS-revised.pdf Figs_revised.pdf Table S.pdf |
|---|---|
| Author | Kondo, Hideki| Hirano, Shuichi| Chiba, Sotaro| Andika, Ida Bagus| Hirai, Makoto| Maeda, Takanori| Tamada, Tetsuo| |
| Keywords | AlkB Benyvirus Burdock mottle virus Endogenous viral element Paleovirology Transcriptome shotgun assembly |
| Published Date | 2013-10 |
| Publication Title | Virus Research |
| Volume | volume177 |
| Issue | issue1 |
| Publisher | Elsevier Science |
| Start Page | 75 |
| End Page | 86 |
| ISSN | 01681702 |
| NCID | AA10642076 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 23911632 |
| DOI | 10.1016/j.virusres.2013.07.015 |
| Web of Science KeyUT | 000324974100009 |
| Related Url | isVersionOf https://doi.org/10.1016/j.virusres.2013.07.015 |
| FullText URL | VirusRes_213_353.pdf tables_revised.pdf Fig S.pdf Supplementary_tables_revised.pdf |
|---|---|
| Author | Kondo, Hideki| Hisano, Sakae| Chiba, Sotaro| Maruyama, Kazuyuki| Andika, Ida Bagus| Toyoda, Kazuhiro| Fujimori, Fumihiro| Suzuki, Nobuhiro| |
| Keywords | Deep sequencing Double stranded RNA virus Powdery mildew Saccharomyces cerevisiae virus L-A Totivirus Ustilago maydis virus H1 |
| Published Date | 2016-02 |
| Publication Title | Virus Research |
| Volume | volume213 |
| Publisher | Elsevier Science |
| Start Page | 353 |
| End Page | 364 |
| ISSN | 01681702 |
| NCID | AA10642076 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 26592174 |
| DOI | 10.1016/j.virusres.2015.11.015 |
| Web of Science KeyUT | 000371840600042 |
| Related Url | isVersionOf https://doi.org/10.1016/j.virusres.2015.11.015 |
| JaLCDOI | 10.18926/AMO/57379 |
|---|---|
| FullText URL | 73_5_469.pdf |
| Author | Yamasaki, Satoshi| Kada, Akiko| Nagai, Hirokazu| Yoshida, Isao| Choi, Ilseung| Saito, Akiko M.| Iwasakia, Hiromi| |
| Abstract | Romidepsin is an important therapeutic option for patients with peripheral T-cell lymphoma (PTCL). However, the timing of romidepsin administration remains controversial. Romidepsin was launched in Japan as a consolidation therapy agent after conventional salvage chemotherapy with gemcitabine, dexamethasone, and cisplatin (GDP). GDP therapy will be administered every 3 weeks. If complete response, partial response, or stable disease is confirmed after 2-4 GDP cycles, romidepsin will be administered every 4 weeks. The primary endpoint is a 2-year progression-free survival rate. Patients participating in this study and undergoing treatment can expect results similar to or better than those of conventional therapies. |
| Keywords | peripheral T-cell lymphoma not otherwise specified angioimmunoblastic T-cell lymphoma gemcitabine cisplatin, romidepsin |
| Amo Type | Clinical Study Protocol |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 469 |
| End Page | 474 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649375 |
| Web of Science KeyUT | 000491886600014 |
| JaLCDOI | 10.18926/AMO/57378 |
|---|---|
| FullText URL | 73_5_463.pdf |
| Author | Shibata, Kiyo| Hamasaki, Ichiro| Shimizu, Takehiro| Kono, Reika| Ohtsuki, Hiroshi| Morizane, Yuki| Shiraga, Fumio| |
| Abstract | To permit noose movement without fraying the sutures following strabismus surgery, we designed a new sliding noose, the “twist knot” and investigated its advantages and disadvantages. We measured the tensile strength required to move the twist knot in a tightly tied state (134±19 gf) and in a loosened state (21±7 gf), and that required to move the conventional sliding noose in a tightly tied state (48±14 gf), and used the Kruskal-Wallis test to compare them. A significant difference was observed among the three tensile strengths (p<0.001). The twist knot technique allowed easy sliding without the multifilament braided suture becoming frayed and a knot to be firmly fixed without slipping. However, if the 2 strings of the pole sutures exit from the sclera at 2 widely separated positions, the sliding noose may become slack. Therefore, the distance between the pole sutures should be small. The simple twist knot technique was found to be an effective approach following adjustable surgery of strabismus. |
| Keywords | adjustable suture the new sliding noose method tensile strength strabismus surgery esotropia |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 463 |
| End Page | 468 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649374 |
| Web of Science KeyUT | 000491886600013 |
| JaLCDOI | 10.18926/AMO/57377 |
|---|---|
| FullText URL | 73_5_457.pdf |
| Author | Iwamuro, Masaya| Takahara, Masahiro| Yamazaki, Tatsuhiro| Tanaka, Takehiro| Kondo, Yoshitaka| Hiraoka, Sakiko| Okada, Hiroyuki| |
| Abstract | A 60-year-old Caucasian male was diagnosed with lung adenocarcinoma and multiple metastases to the bone, spleen, and brain. He underwent radiotherapy for the brain and lumbar spine metastases, plus chemotherapy (cisplatin and pemetrexed). The chemotherapy was discontinued due to vomiting and hyponatremia, and nivolumab was then administered. Eight months later, 18F-fluorodeoxyglucose positron emission tomography showed tracer uptake in the colon. Colonoscopy revealed a reddish multinodular polyp in the sigmoid colon. The polyp showed irregular microvessels. No colonic mucosal surface structures were observed. Colonic metastasis of the lung carcinoma was highly suspected; the polyp was therefore surgically removed. The histological analysis revealed granulation tissue and suppurative inflammation without neoplastic changes. We diagnosed the lesion as a granulation polyp. Despite the difficulty in diagnosing these lesions due to their rarity and similarity to metastatic colon tumors, we suggest that recognizing the endoscopic features of the polyp surface may allow a preoperative diagnosis. |
| Keywords | colonoscopy colonic neoplasms granulation polyp |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 457 |
| End Page | 461 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649373 |
| Web of Science KeyUT | 000491886600012 |
| JaLCDOI | 10.18926/AMO/57376 |
|---|---|
| FullText URL | 73_5_449.pdf |
| Author | Matsunaga, Kazuyuki| Takemaru, Makoto| Yamashiro, Keisuke| Yoshihara-Hirata, Chiaki| Inohara, Ken| Shimoe, Yutaka| Tanaka, Akio| Kuriyama, Masaru| Takashiba, Shogo| |
| Abstract | We report a case of acute prevertebral abscess caused by traumatic tooth fractures in a 77-year-old Japanese man. After being transferred to our hospital the patient was initially diagnosed with a neck hematoma; however, blood culture showed Streptococcus parasanguinis, an oral bacterium, and an MRI examination suggested prevertebral abscesses. Tooth fractures, severe periodontitis, and peri-implantitis with Streptococcus parasanguinis were observed. Antibiotics were administered and fractured teeth were extracted. The patient's condition then gradually improved. We concluded that bacteremia caused by traumatic tooth fractures induced the acute prevertebral abscesses. |
| Keywords | prevertebral abscess deep neck infection periodontal disease peri-implantitis Streptococcus parasanguinis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 449 |
| End Page | 456 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649372 |
| Web of Science KeyUT | 000491886600011 |
| JaLCDOI | 10.18926/AMO/57375 |
|---|---|
| FullText URL | 73_5_441.pdf |
| Author | Watanabe, Toshiyuki| Sakurai, Toru| Mukai, Yuko| Kimata, Yoshihiro| Namba, Yuzaburo| |
| Abstract | Gender dysphoria is a condition in which a discrepancy between biological sex and gender identity causes distress. Many female-to-male transsexuals (FTMTS) are uncomfortable with female breasts. Chest wall contouring surgery is effective for obtaining a male-type chest, reducing mental stress, and increasing sexual satisfaction in such cases. At the Okayama University Hospital Gender Center, we have obtained positive results using an algorithm to determine the most appropriate surgical method for chest wall contouring in FTMTS patients. However, serious complications requiring reoperation, such as hematoma, may still occur. Postoperative hematomas were found in 15 (4.18%) of 358 FTMTS patients who underwent chest contouring surgery at our hospital between 2006 and 2018. Postoperative hematoma was examined retrospectively. The median time to the onset of hematoma was 7 (6-12) h after the initial surgery. The main blood vessels causing bleeding were those in the head-side skin flap region where visual confirmation was difficult and the perforator vessels from the pectoralis major muscle. Intraoperative bleeding and the operation time had a significant impact on the onset of postoperative hematoma. This is the first retrospective study that investigated the blood vessels and other factors contributing to postoperative hematoma development after chest wall contouring. |
| Keywords | female-to-male transsexuals chest wall contouring postoperative hematoma |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 441 |
| End Page | 447 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649371 |
| Web of Science KeyUT | 000491886600010 |
| JaLCDOI | 10.18926/AMO/57374 |
|---|---|
| FullText URL | 73_5_433.pdf |
| Author | Tamada, Shoko| Mitsui, Takashi| Ohira, Akiko| Tani, Kazumasa| Maki, Jota| Eguchi, Takeshi| Eto, Eriko| Hayata, Kei| Masuyama, Hisashi| |
| Abstract | An association between preeclampsia and (pro)renin was recently reported. Intracellular signaling of the (pro) renin receptor [(P)RR] increases the expressions of TGF-β and PAI-1. In this study we sought to clarify the involvement of (pro)renin in the pathogenesis of preeclampsia via the intracellular signaling of (P)RR on preeclampsia placentas. Activated (pro)renin plasma concentrations were compared between pregnant women with (n=15) and without (n=28) preeclampsia. The placentas were immunohistochemically evaluated with anti-HIF-1α and anti-(P)RR antibodies. HTR-8/SVneo cells were cultured under hypoxic conditions and treated with human recombinant (pro)renin. The mRNA expressions of HIF-1α, (P)RR, PAI-1, TGF-β, and ET-1 were also examined by real-time RCR. The activated (pro)renin plasma concentration was significantly higher in the third vs. the second trimester in the preeclampsia patients. HIF-1α and (P)RR expressions were significantly increased in the preeclampsia placentas. The mRNA expressions of PAI-1, TGF-β, and ET-1 were significantly increased in the experiments using recombinant (pro)renin vs. hypoxic conditions. (P)RR expression in preeclampsia placentas is increased by persistent hypoxia through the second and third trimesters, and PAI-1, TGF-β, and ET-1 production is increased via (P)RR. Our results suggest that ET-1 production via the intracellular signaling of (P)RR is important in the pathogenesis of preeclampsia. |
| Keywords | preeclampsia (pro)renin (pro)renin receptor endothelin-1 HTR-8/SVneo |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 433 |
| End Page | 440 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649370 |
| Web of Science KeyUT | 000491886600009 |
| JaLCDOI | 10.18926/AMO/57373 |
|---|---|
| FullText URL | 73_5_427.pdf |
| Author | Owari, Yutaka| Suzuki, Hiromi| Miyatake, Nobuyuki| |
| Abstract | The aim of this study was to examine in a randomized controlled trial how much the sedentary behavior (sitting time) of community-dwelling elderly Japanese subjects decreased as a result of using the “Active Guide” brochure published by the Ministry of Health, Labour and Welfare (2013) and additional documents related to the benefits of reducing sedentary behavior. A total of 86 elderly people who participated in health-club activities for one year were randomly allocated to two groups. Subjects in the intervention group received explanations of the importance of physical activity using the “Active Guide” brochure (n=42) and additional documents, while subjects in the control group did not (n=44). Physical activity was measured using a triaxial accelerometer for two weeks at baseline and again after one year. After one year of intervention, the difference in the sedentary behavior rate from baseline was −2.2% for the intervention group (n=40) and +2.5% for controls (n=40) (Welch’s t-test, p=0.007). Use of the “Active Guide” brochure and additional documents may reduce the sedentary behavior of community dwelling elderly people in Japan. |
| Keywords | Active Guide sedentary behavior elderly people randomized controlled trial health promotion |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 427 |
| End Page | 432 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649369 |
| Web of Science KeyUT | 000491886600008 |
| JaLCDOI | 10.18926/AMO/57372 |
|---|---|
| FullText URL | 73_5_419.pdf |
| Author | Hishii, Shuhei| Miyatake, Nobuyuki| Nishi, Hiroyuki| Katayama, Akihiko| Ujike, Kazuhiro| Koumoto, Kiichi| Suzuki, Hiromi| Hashimoto, Hiroo| |
| Abstract | We investigated the relationship between sedentary behavior and all-cause mortality in patients undergoing hemodialysis. A total of 71 patients (39 men, 32 women, aged 72.1±11.7 years) were enrolled in this longitudinal study. Their sedentary behavior was measured using a tri-accelerometer that provides relative values per daily wearing time. We classified the sedentary behavior time into 2 groups (under the median: short-sedentary behavior (SB) group; over the median: long-SB group) and compared the groups’ clinical parameters. We compared the groups’ survival rates by using Kaplan-Meier curves and the log-rank test, and we performed multivariate analyses by a Cox-proportional hazard model to evaluate the relationship between the sedentary behavior and the survival rate. Twenty patients (28.2%) died during the observation period. The survival rate of the short-SB group was significantly higher than that of the long-SB group. Sedentary behavior was thus an important factor for all-cause mortality even after adjusting for confounding factors by a Cox-proportional hazard model. Sedentary behavior is closely linked to all-cause mortality, especially total days and non-hemodialysis days, and reducing sedentary behavior may be beneficial to reduce the all-cause mortality of patients on chronic hemodialysis. |
| Keywords | sedentary behavior hemodialysis mortality physical activity |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 419 |
| End Page | 425 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649368 |
| Web of Science KeyUT | 000491886600007 |
| JaLCDOI | 10.18926/AMO/57371 |
|---|---|
| FullText URL | 73_5_413.pdf |
| Author | Yanagihara, Yutaka| Nishida, Keigo| Watanabe, Ryuta| Koyama, Kanae| Sawada, Yuichiro| Noda, Terutaka| Asai, Seiji | Fukumoto, Tetsuya| Miura, Noriyoshi| Miyauchi, Yuki| Kikugawa, Tadahiko| Saika, Takashi| |
| Abstract | Laparoscopic radical cystectomy (LRC) is a standard surgical treatment for muscle-invasive bladder cancer and high-risk non-muscle-invasive bladder cancer. LRC is a less invasive modality than conventional open surgery. Therefore, even elderly patients with invasive bladder cancer may be candidates for LRC. In this study, a comparative analysis of perioperative/oncological outcomes between elderly patients and younger patients who underwent LRC was performed to assess the feasibility of LRC in elderly patients. Sixty-eight consecutive patients who underwent LRC between October 2013 and March 2018 were enrolled and stratified into those younger than 75 years (n=37) and those ≥ 75 years old (n=31). The median follow-up period was 28.2 months. The preoperative and operative parameters and complications were similar in both groups. The 2-year overall survival (OS) was 64.4% in the younger vs. 76.4% in the elderly group (p=0.053), cancer-specific survival (CSS) was 79.3% vs. 81.7% (p=0.187), and recurrence-free survival (RFS) was 58.2% vs. 75.7% (p=0.174), respectively. No significant differences were observed in OS, CSS, or RFS between the groups. No significant differences were found between the groups with respect to peri-surgical/oncological outcomes. We conclude that LRC is feasible in elderly patients. |
| Keywords | bladder cancer laparoscopic surgery radical cystectomy elderly patient |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2019-10 |
| Volume | volume73 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 417 |
| End Page | 418 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2019 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 31649367 |
| Web of Science KeyUT | 000491886600006 |
