result 5995 件
| FullText URL | K0006687_abstract_review.pdf K0006687_fulltext.pdf K0006687_summary.pdf |
|---|---|
| Author | HAN, YANYAN| |
| Published Date | 2022-09-22 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6687号 |
| Granted Date | 2022-09-22 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2020 by The Japanese Society for Lymphoreticular Tissue Research |
| FullText URL | K0006686_abstract_review.pdf K0006686_fulltext.pdf K0006686_summary.pdf |
|---|---|
| Author | TOKUMASU, Miho| |
| Published Date | 2022-09-22 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第6686号 |
| Granted Date | 2022-09-22 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| Copyright Holders | © 2022, Oxford University Press |
| JaLCDOI | 10.18926/AMO/64044 |
|---|---|
| FullText URL | 76_5_609.pdf |
| Author | Matsumoto, Ken| Fujishita, Keigo| Matsuda, Masayuki| Oka, Satoshi| Fujisawa, Yuka| Imai, Toshi| Machida, Takuya| |
| Abstract | A 69-year-old Japanese man with acute leukemia received post-transplant cyclophosphamide-based haploidentical stem cell transplantation (PTCY-haplo-SCT) but was readmitted with dyspnea and ground-glass-opacities of the lungs. Bronchoscopy showed inflammatory changes with no signs of infection. He received steroids but required intubation as his condition deteriorated. In addition to antithymocyte globulin and cyclophosphamide, we administered ruxolitinib but failed to save him. Autopsy findings revealed fibrotic nonspecific interstitial pneumonia (NSIP) without evidence of organizing pneumonia or infection. Thus, we diagnosed idiopathic pneumonia syndrome (IPS). As far as our knowledge, this is the first case of IPS with NSIP histology after PTCY-haplo-SCT. |
| Keywords | idiopathic pneumonia syndrome ruxolitinib post-transplant cyclophosphamide-based haploidentical stem cell transplantation nonspecific interstitial pneumonia |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 609 |
| End Page | 615 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352810 |
| Web of Science KeyUT | 000884907100016 |
| JaLCDOI | 10.18926/AMO/64040 |
|---|---|
| FullText URL | 76_5_585.pdf |
| Author | Choshi, Haruki| Watanabe, Mototsugu| Furukawa, Shinichi| Ujike, Hiroyuki| Kataoka, Kazuhiko| |
| Abstract | Pulmonary metastatic resection is a standard therapy for renal cell carcinoma (RCC). Although patients with pulmonary metastases who do not undergo any treatment have poor prognoses, it has been reported that resection for pulmonary metastases yields good clinical outcomes. We investigated the prognoses of the 10 Japanese patients (eight males, two females) who underwent a surgical resection of pulmonary metastasectomy from RCC at our institution between April 1, 2012 and March 31, 2020 and analyzed the prognostic factors. We determined the prognoses and calculated the 5-year overall survival (OS) and disease-free survival (DFS) rates. To identify prognostic factors, we compared the median DFS duration for each factor. Elderly patients (median age, 75.5 years) were more predominant compared to previous studies, and all 10 patients underwent a complete resection. The 5-year DFS rate was 30.5% (95%CI: 0.045-0.63) and the 5-year OS rate was 80% (95%CI: 0.20-0.97). The following factors were associated with better prognosis: female, disease-free interval≥36 months, and metastases size<12 mm. These results indicate that complete resection for pulmonary metastases from RCC resulted in good clinical outcomes, particularly for patients with better prognostic factors. |
| Keywords | renal cell carcinoma pulmonary metastasis complete resection |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 585 |
| End Page | 591 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352806 |
| Web of Science KeyUT | 000884907100012 |
| JaLCDOI | 10.18926/AMO/64036 |
|---|---|
| FullText URL | 76_5_547.pdf |
| Author | Kagawa, Hidetoshi| Yamanaka, Ryutaro| Hiromasa, Tsutomu| |
| Abstract | This observational study aimed to clarify the long-term results of the combination of mizoribine (MZB), tacrolimus (TAC) and prednisolone as first-line therapy for lupus nephritis (LN). This was our institution’s standard therapy between 2009 and 2015, when we saw 36 patients with LN. When a patient thus treated achieved SLEDAI remission (= 0) and/or the prednisolone dose could be tapered to 5 mg/day, either MZB or TAC was stopped, and the other was continued for maintenance therapy. If treatment failure or relapse occurred, second-line therapy was introduced. At years 1 and 5, overall complete renal response and SLEDAI remission were 94% and 88%, and 50% and 62%, respectively. Excluding 2 cases lost to follow-up, medications after 5 years were as follows: 20 (59%) were stable on 1 drug (MZB or TAC), 11 (32%) required continuation of both drugs (MZB + TAC), and 3 (9%) required second-line therapy. The 5-year retention rate was 91% (non-secondline), with 0% of relapse in this group. Our first-line combination strategy showed high remission rates in the induction phase, and subsequent maintenance therapy demonstrated good outcomes for up to 5 years. Research that fine-tunes the order of therapeutic agents and institutes appropriate treatment goals may further improve long-term outcomes for patients with LN. |
| Keywords | combination therapy first-line therapy lupus nephritis mizoribine tacrolimus |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 547 |
| End Page | 555 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352802 |
| Web of Science KeyUT | 000884907100008 |
| JaLCDOI | 10.18926/AMO/64033 |
|---|---|
| FullText URL | 76_5_527.pdf |
| Author | Makihara, Seiichiro| Kariya, Shin| Miyamoto, Shotaro| Uraguchi, Kensuke| Oka, Aiko| Tsumura, Munechika| Noda, Yohei| Ando, Mizuo| Okano, Mitsuhiro| |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 527 |
| End Page | 533 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352799 |
| Web of Science KeyUT | 000884907100005 |
| JaLCDOI | 10.18926/AMO/64025 |
|---|---|
| FullText URL | 76_5_503.pdf |
| Author | Ogawa, Hirohito| Honda, Tomoyuki| |
| Abstract | Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. |
| Keywords | EVE nrEVE bornavirus filovirus antiviral |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 503 |
| End Page | 510 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352796 |
| Web of Science KeyUT | 000884907100002 |
| JaLCDOI | 10.18926/AMO/64024 |
|---|---|
| FullText URL | 76_5_489.pdf |
| Author | Matsumoto, Yuji| Ichikawa, Tomotsugu| Kurozumi, Kazuhiko| Date, Isao| |
| Abstract | Glioblastoma (GBM) is a fatal primary malignant brain tumor in adults. Despite decades of research, the prognosis for GBM patients is still disappointing. One major reason for the intense therapeutic resistance of GBM is inter- and intra-tumor heterogeneity. GBM-intrinsic transcriptional profiling has suggested the presence of at least three subtypes of GBM: the proneural, classic, and mesenchymal subtypes. The mesenchymal subtype is the most aggressive, and patients with the mesenchymal subtype of primary and recurrent tumors tend to have a worse prognosis compared with patients with the other subtypes. Furthermore, GBM can shift from other subtypes to the mesenchymal subtype over the course of disease progression or recurrence. This phenotypic transition is driven by diverse tumor-intrinsic molecular mechanisms or microenvironmental factors. Thus, better understanding of the plastic nature of mesenchymal transition in GBM is pivotal to developing new therapeutic strategies. In this review, we provide a comprehensive overview of the current understanding of the elements involved in the mesenchymal transition of GBM and discuss future perspectives. |
| Keywords | glioma glioblastoma mesenchymal subtype mesenchymal transition heterogeneity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-10 |
| Volume | volume76 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 489 |
| End Page | 502 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 36352795 |
| Web of Science KeyUT | 000884907100001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamada, Hiroshi| Abe, Tadashi| Nagaoka, Hikaru| Takashima, Eizo| Nitta, Ryo| Yamamoto, Masahiro| Takei, Kohji| |
| Keywords | IFN-inducible GTPase Irgb6 GTPase membrane T gondii |
| Published Date | 2022-09-09 |
| Publication Title | Frontiers In Cellular And Infection Microbiology |
| Volume | volume12 |
| Publisher | Frontiers Media |
| Start Page | 992198 |
| ISSN | 2235-2988 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Yamada, Abe, Nagaoka, Takashima, Nitta, Yamamoto and Takei. |
| File Version | publisher |
| PubMed ID | 36159643 |
| DOI | 10.3389/fcimb.2022.992198 |
| Web of Science KeyUT | 000873786000001 |
| Related Url | isVersionOf https://doi.org/10.3389/fcimb.2022.992198 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kataoka, Motoki| Misawa, Masaaki| Tsuruta, Kenji| |
| Keywords | phononic crystal topological acoustic elastic waveguide backscattering length lamb wave |
| Published Date | 2022-10-13 |
| Publication Title | Symmetry |
| Volume | volume14 |
| Issue | issue10 |
| Publisher | MDPI |
| Start Page | 2133 |
| ISSN | 2073-8994 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| DOI | 10.3390/sym14102133 |
| Web of Science KeyUT | 000873707300001 |
| Related Url | isVersionOf https://doi.org/10.3390/sym14102133 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Araki, Hiroyuki| Tazawa, Hiroshi| Kanaya, Nobuhiko| Kajiwara, Yoshinori| Yamada, Motohiko| Hashimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Published Date | 2022-12-15 |
| Publication Title | Molecular Therapy - Oncolytics |
| Volume | volume27 |
| Publisher | Cell Press |
| Start Page | 3 |
| End Page | 13 |
| ISSN | 2372-7705 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 36212775 |
| DOI | 10.1016/j.omto.2022.09.003 |
| Web of Science KeyUT | 000870232500001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.omto.2022.09.003 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Gao, Shangze| Liu, Keyue| Ku, Wenhan| Wang, Dengli| Wake, Hidenori| Qiao, Handong| Teshigawara, Kiyoshi| Nishibori, Masahiro| |
| Keywords | Histamine HMGB1 vascular endothelial cell H-1 receptor hypotension |
| Published Date | 2022-10-05 |
| Publication Title | Frontiers In Immunology |
| Volume | volume13 |
| Publisher | Frontiers Media SA. |
| Start Page | 930683 |
| ISSN | 1664-3224 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Gao, Liu, Ku, Wang, Wake, Qiao, Teshigawara and Nishibori. |
| File Version | publisher |
| PubMed ID | 36275732 |
| DOI | 10.3389/fimmu.2022.930683 |
| Web of Science KeyUT | 000873745300001 |
| Related Url | isVersionOf https://doi.org/10.3389/fimmu.2022.930683 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Fithroni, Abdul Basith| Kobayashi, Kazuko| Uji, Hirotaka| Ishimoto, Manabu| Akehi, Masaru| Ohtsuki, Takashi| Matsuura, Eiji| |
| Keywords | boron neutron capture therapy (BNCT) biologically self-degradable amphipathic polymer (Lactosome) hydrophobic boron cluster carborane isomers or o-carborane alkylated derivatives molecular glue effect |
| Published Date | 2022-10-21 |
| Publication Title | CELLS |
| Volume | volume11 |
| Issue | issue20 |
| Publisher | MDPI |
| Start Page | 3307 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36291173 |
| DOI | 10.3390/cells11203307 |
| Web of Science KeyUT | 000872497500001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells11203307 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Shigehiro, Tsukasa| Ueno, Maho| Kijihira, Mayumi| Takahashi, Ryotaro| Umemura, Chiho| Taha, Eman A.| Kurosaka, Chisaki| Asayama, Megumi| Murakami, Hiroshi| Satoh, Ayano| Nakamura, Yoshimasa| Futami, Junichiro| Masuda, Junko| |
| Keywords | breast cancer cells dendritic cells mesenteric lymph node myeloid-derived suppressor cells |
| Published Date | 2022-09-20 |
| Publication Title | International Journal Of Molecular Sciences |
| Volume | volume23 |
| Issue | issue19 |
| Publisher | MDPI |
| Start Page | 11035 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36232335 |
| DOI | 10.3390/ijms231911035 |
| Web of Science KeyUT | 000867767200001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms231911035 |
| FullText URL | fulltext20230112-5.pdf |
|---|---|
| Author | Matsuo, Toshihiko| Tanaka, Takehiro| Omote, Rika| Okada, Toshiaki| Notohara, Kenji| Okada, Kazuya| |
| Published Date | 2022 |
| Publication Title | Journal of Clinical and Experimental Hematopathology |
| Volume | volume62 |
| Issue | issue4 |
| Publisher | Japanese Society for Lymphoreticular Tissue Research |
| Start Page | 226 |
| End Page | 237 |
| ISSN | 1346-4280 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Japanese Society for Lymphoreticular Tissue Research |
| File Version | publisher |
| PubMed ID | 36171112 |
| DOI | 10.3960/jslrt.22015 |
| Related Url | isVersionOf https://doi.org/10.3960/jslrt.22015 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tokumitsu, Hiroshi| Sakagami, Hiroyuki| |
| Keywords | CaMKK CaM-kinase cascade Ca2+ signaling phosphorylation |
| Published Date | 2022-09-20 |
| Publication Title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
| Volume | volume23 |
| Issue | issue19 |
| Publisher | MDPI |
| Start Page | 11025 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36232320 |
| DOI | 10.3390/ijms231911025 |
| Web of Science KeyUT | 000867778400001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms231911025 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Wang, Dengli| Ousaka, Daiki| Qiao, Handong| Wang, Ziyi| Zhao, Kun| Gao, Shangze| Liu, Keyue| Teshigawara, Kiyoshi| Takada, Kenzo| Nishibori, Masahiro| |
| Keywords | intracerebral hemorrhage HMGB1 antibody therapy non-human primate |
| Published Date | 2022-09-23 |
| Publication Title | Cells |
| Volume | volume11 |
| Issue | issue19 |
| Publisher | MDPI |
| Start Page | 2970 |
| ISSN | 2073-4409 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36230933 |
| DOI | 10.3390/cells11192970 |
| Web of Science KeyUT | 000866922400001 |
| Related Url | isVersionOf https://doi.org/10.3390/cells11192970 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Makimoto, Go| Shimonishi, Atsushi| Ohashi, Kadoaki| Ninomiya, Kiichiro| Higo, Hisao| Kato, Yuka| Fujii, Masanori| Kubo, Toshio| Ichihara, Eiki| Hotta, Katsuyuki| Tabata, Masahiro| Maeda, Yoshinobu| Kiura, Katsuyuki| |
| Keywords | MET Tepotinib Non-small-cell lung cancer |
| Published Date | 2022 |
| Publication Title | Case Reports In Oncology |
| Volume | volume15 |
| Issue | issue2 |
| Publisher | Karger |
| Start Page | 494 |
| End Page | 498 |
| ISSN | 1662-6575 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 35702678 |
| DOI | 10.1159/000524326 |
| Web of Science KeyUT | 000864085100005 |
| Related Url | isVersionOf https://doi.org/10.1159/000524326 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kondo, Yuki| Rikiishi, Kazuhide| Sugimoto, Manabu| |
| Keywords | 8-oxo-dGTP nudix hydrolase Oryza sativa transcriptional error UV-C |
| Published Date | 2022-09 |
| Publication Title | Antioxidants |
| Volume | volume11 |
| Issue | issue9 |
| Publisher | MDPI |
| Start Page | 1805 |
| ISSN | 2076-3921 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 by the authors. |
| File Version | publisher |
| PubMed ID | 36139879 |
| DOI | 10.3390/antiox11091805 |
| Web of Science KeyUT | 000858199700001 |
| Related Url | isVersionOf https://doi.org/10.3390/antiox11091805 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Naka, Shuhei| Matsuoka, Daiki| Goto, Kana| Misaki, Taro| Nagasawa, Yasuyuki| Ito, Seigo| Nomura, Ryota| Nakano, Kazuhiko| Matsumoto-Nakano, Michiyo| |
| Keywords | Streptococcus mutans collagen-binding protein membrane permeability cell structure RNA-seq |
| Published Date | 2022-09-13 |
| Publication Title | Frontiers In Cellular And Infection Microbiology |
| Volume | volume12 |
| Publisher | Frontiers Media S.A. |
| Start Page | 994014 |
| ISSN | 2235-2988 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 Naka, Matsuoka, Goto, Misaki, Nagasawa, Ito, Nomura, Nakano and Matsumoto-Nakano. |
| File Version | publisher |
| PubMed ID | 36176579 |
| DOI | 10.3389/fcimb.2022.994014 |
| Web of Science KeyUT | 000861324100001 |
| Related Url | isVersionOf https://doi.org/10.3389/fcimb.2022.994014 |
