result 24391 件
| JaLCDOI | 10.18926/54535 |
|---|---|
| Title Alternative | On the 1895 publication of "Nihongo Hitori Annnai" |
| FullText URL | bhe_011_043_054.pdf |
| Author | Jin, Namtaek| |
| Abstract | 本稿では開化期の日本語学習書である『日本語独案内』（1895）に関して、その構成、韓国語の特徴、本書の基になっていると考えられる『日韓會話』（1894）と異なる日本語の単語や表現などを考察する。本書は日本語学書でありながら、その韓国語は同時代のほかの韓国語学習書と比べても同時代の韓国語を良く反映していると思われ、言語学的な価値を持っているといえる。また、『日韓會話』（1894）は本書の他にも『旅行必要日韓清對話自在』（1894）の定本にもなっており、『朝鮮語学独案内』（1894）との関連性mおうかがえる。今後、明治期のほかの韓国語学習書や韓国人のための日本語学習書を総合的に考察することで、現代韓国語の形成過程を寄り明らかにできると期待される。 |
| Keywords | 韓国語 日本語独案内 開化期 日韓會話 |
| Publication Title | Bulletin of Higher Education Okayama University |
| Published Date | 2015-12-30 |
| Volume | volume11 |
| Start Page | 43 |
| End Page | 54 |
| ISSN | 1881-5952 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005838013 |
| JaLCDOI | 10.18926/54534 |
|---|---|
| Title Alternative | La constellation des imprimeurs-libraires dans les années 1640 et la polémique autour du jansénisme |
| FullText URL | bhe_011_033_042.pdf |
| Author | Noro, Yasushi| |
| Abstract | 今日ジャンセニスムといえば，神学者コルネリウス・ジャンセニウス(1585-1638)の名に因んだ社会運動を指す．彼の遺稿『アウグスチヌス』と，その擁護者であるアントワヌ・アルノーによる『頻繁なる聖体拝領について』は，1640 年代に大きな論争を巻き起こした．これがいわゆる初期ジャンセニスム論争である．この論争は当時最大のメディアである書物を中心に展開されたがゆえに，文書の出版に携わる出版業界の動きとも深く関係したのは間違いない．但し，予めジャンセニスムとそれに共感した業者がいたというのではない．宗教思想や業者間の対立が折り重なる場でこそ，ジャンセニスムなるものが産み出され，漸次的に規定されてゆくのである． |
| Keywords | ジャンセニスム 論争 出版 メディア 頻繁なる聖体拝領について |
| Publication Title | Bulletin of Higher Education Okayama University |
| Published Date | 2015-12-30 |
| Volume | volume11 |
| Start Page | 33 |
| End Page | 42 |
| ISSN | 1881-5952 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005838012 |
| JaLCDOI | 10.18926/54533 |
|---|---|
| Title Alternative | De l’histoire littéraire au champ littéraire: Saisei MURO et la poésie japonaise moderne (2) |
| FullText URL | bhe_011_011_032.pdf |
| Author | Ueda, Kazuhiro| |
| Abstract | ある時代のある特定の時期に書かれ発表されたさまざまな文学テクストをながめたばあい、ときにジャンルさえ越えて、そこに流行語のようにいくつかのある特徴的な語や表現が時を同じくして出現してくることがある。それはもちろん作家（詩人）から作家（詩人）へのなんらかの影響関係がそこにあったからだとまずは考えられよう。しかしこれは必ずしもたんに一方から他方への単方向的な影響というのではなく、作家（詩人）たちのあいだで、いくつかの条件があわさって、ほとんど同時発生的にある共通ないし類似の語や表現が生まれたり用いられたりすることもあったのではないか、また、あくまで個々の作品から遡及的にしか見いだされぬとしても、そうした共通ないし類似の語や表現を生みだすことを可能にした、ある時代のある特定の時期に成立していたと想定される表現可能態の言語空間がそこに潜在していたのではないか――本稿は、その空間をピエール・ブルデューの用語を借りて「文学場」の名で呼んで、20 世紀初頭における日本の近代詩と19 世紀中葉におけるフランスの近代詩をそうした「文学場」という観点からとらえなおす試みである。 |
| Keywords | 文学場 日本近代詩 室生犀星 北原白秋 斎藤茂吉 |
| Publication Title | Bulletin of Higher Education Okayama University |
| Published Date | 2015-12-30 |
| Volume | volume11 |
| Start Page | 11 |
| End Page | 32 |
| ISSN | 1881-5952 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005838011 |
| JaLCDOI | 10.18926/54532 |
|---|---|
| Title Alternative | "Romeo und Julia" auf der Opernbühne ― Von Gottfried Keller zu Frederic Delius ― |
| FullText URL | bhe_011_001_010.pdf |
| Author | Kubota, Satoshi| |
| Abstract | 互いの家同士の確執を知りながらも愛し合うことになってしまった男女の悲劇を描き出したシェイクスピアの作品のプロットが19 世紀リアリズム期の作家ゴットフリート・ケラーの『村のロメオとユリア』においてもそっくりのまま使い回されたわけでは決してない。現実を見つめるケラーのまなざしは悲劇に至る経緯と背景を丹念に追い求めているのである。しかしながらドイツにルーツを持つイギリス人作曲家フレデリック・ディーリアスがシェイクスピアではなくケラーの小説の方をオペラの題材に選んだ時、音楽家としての感性はリアリズム小説のプロットにさまざまな変更を施すことになる。 |
| Keywords | 確執 リアリズム 示導動機 「楽園」 夢 |
| Publication Title | Bulletin of Higher Education Okayama University |
| Published Date | 2015-12-30 |
| Volume | volume11 |
| Start Page | 1 |
| End Page | 10 |
| ISSN | 1881-5952 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005838010 |
| Author | Hanaya, Tadashi| Sato, Nobuaki| Yamamoto, Hiroshi| |
|---|---|
| Published Date | 2007-04 |
| Publication Title | Heterocycles |
| Volume | volume71 |
| Issue | issue3 |
| Content Type | Journal Article |
| Title Alternative | Personalbeurteilung in deutschen privaten Unternehmen |
|---|---|
| FullText URL | olj_66_1_(101)_(188).pdf |
| Author | Tohnai, K.| |
| Publication Title | Okayama Law Journal |
| Published Date | 2016-08-31 |
| Volume | volume66 |
| Issue | issue1 |
| Start Page | 188 |
| End Page | 101 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| Title Alternative | On the Retirement Compensation of Directors Based on the Internal Regulation of the Corporation without the Resolution of Shareholders’ Meeting : Tokyo District Court Decision of 21 July 2015 |
|---|---|
| FullText URL | olj_66_1_(189)_(198).pdf |
| Author | Yoneyama, Kiichiro| |
| Publication Title | Okayama Law Journal |
| Published Date | 2016-08-31 |
| Volume | volume66 |
| Issue | issue1 |
| Start Page | 198 |
| End Page | 189 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005838009 |
| Title Alternative | Die Intellektuelle und die ‘Bildung’ : Der Bildungsgedanke von Maruyama Masao |
|---|---|
| FullText URL | olj_66_1_001_088.pdf |
| Author | Nishimura, M.| |
| Publication Title | Okayama Law Journal |
| Published Date | 2016-08-31 |
| Volume | volume66 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 88 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005838007 |
| Title Alternative | Personalbeurteilung in deutschen privaten Unternehmen |
|---|---|
| FullText URL | olj_66_1_(236)_(376).pdf |
| Author | Tohnai, K.| |
| Publication Title | Okayama Law Journal |
| Published Date | 2016-08-31 |
| Volume | volume66 |
| Issue | issue1 |
| Start Page | 376 |
| End Page | 236 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005838005 |
| Title Alternative | Reform of Nation-Wide General Tests for University Admissions and its Political Process : Adaptation to Glovalization and Populism |
|---|---|
| FullText URL | olj_66_1_(377)_(422).pdf |
| Author | Tani, Satomi| |
| Publication Title | Okayama Law Journal |
| Published Date | 2016-08-31 |
| Volume | volume66 |
| Issue | issue1 |
| Start Page | 422 |
| End Page | 377 |
| ISSN | 0386-3050 |
| language | Japanese |
| File Version | publisher |
| NAID | 120005838004 |
| JaLCDOI | 10.18926/AMO/54514 |
|---|---|
| FullText URL | 70_4_327.pdf |
| Author | Watanabe, Mototsugu| Yamamoto, Hiromasa| Eikawa, Shingo| Shien, Kazuhiko| Shien, Tadahiko| Soh, Junichi| Hotta, Katsuyuki| Wada, Jun| Hinotsu, Shiro| Fujiwara, Toshiyoshi| Kiura, Katsuyuki| Doihara, Hiroyoshi| Miyoshi, Shinichiro| Udono, Heiichiro| Toyooka, Shinichi| |
| Abstract | A study to evaluate the effect of metformin on the immune system was commenced in July 2014. Metformin is one of the most commonly prescribed drugs for type 2 diabetes, and previous studies have reported that metformin has an anti-tumor effect. The aim of this study is to evaluate the efficacy of metformin on the immune system in human cancer patients in vivo. The primary outcome parameter will be the rate change in the population of CD8＋ T cells, which produce multiple cytokines. |
| Keywords | metformin CD8＋ T cells cancer immunology |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 327 |
| End Page | 330 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549683 |
| Web of Science KeyUT | 000384748600018 |
| JaLCDOI | 10.18926/AMO/54511 |
|---|---|
| FullText URL | 70_4_313.pdf |
| Author | Matsumoto, Kazuyuki| Kato, Hironari| Tsutsumi, Koichiro| Mizukawa, Sho| Yabe, Syuntaro| Seki, Hiroyuki| Akimoto, Yutaka| Uchida, Daisuke| Tomoda, Takeshi| Yamamoto, Naoki| Horiguchi, Shigeru| Okada, Hiroyuki| |
| Abstract | Recently, endoscopic ultrasonography (EUS)-guided ethanol ablation for small pancreatic neuroendocrine tumors (p-NETs) has been reported. However, the efficacy and safety of the technique remain unclear. We have launched a prospective pilot study of EUS-guided ethanol ablation for p-NETs. The major eligibility criteria are the presence of a pathologically diagnosed grade (G) 1 or G2 p-NET, a tumor size of 2cm, and being a poor candidate for surgery. A total of 5 patients will be treated. The primary endpoint will be the complete ablation rate at 1 month after treatment. |
| Keywords | pancreatic neuroendocrine tumor ethanol ablation EUS-guided |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 313 |
| End Page | 316 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549680 |
| Web of Science KeyUT | 000384748600015 |
| JaLCDOI | 10.18926/AMO/54510 |
|---|---|
| FullText URL | 70_4_307.pdf |
| Author | Fujiwara, Masaki| Inagaki, Masatoshi| Higuchi, Yuji| Uchitomi, Yosuke| Terada, Seishi| Kodama, Masafumi| Kishi, Yoshiki| Yamada, Norihito| |
| Abstract | Repetitive transcranial magnetic stimulation (rTMS) has been reported to be a new treatment option for treatment-resistant depression. In Japan, there has been limited research into its feasibility, efficacy, and tolerability. We have launched a trial of rTMS for treating medication-resistant major depressive disorder and bipolar depression. We are investigating low-frequency rTMS to the right dorsolateral prefrontal cortex and traditional high-frequency rTMS to the left dorsolateral prefrontal cortex, in 20 patients. The primary outcome of the study is the treatment completion rate. This study will provide new data on the usefulness of rTMS for treatment-resistant depression in Japan. |
| Keywords | repetitive transcranial magnetic stimulation depression treatment resistance low frequency |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 307 |
| End Page | 311 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549679 |
| Web of Science KeyUT | 000384748600014 |
| JaLCDOI | 10.18926/AMO/54508 |
|---|---|
| FullText URL | 70_4_299.pdf |
| Author | Wada, Koichiro| Uehara, Shinya| Ishii, Ayano| Sadahira, Takuya| Yamamoto, Masumi| Mitsuhata, Ritsuko| Takamoto , Atsushi| Araki, Motoo| Kobayashi, Yasuyuki| Watanabe, Masami| Watanabe, Toyohiko| Hotta, Katsuyuki| Nasu, Yasutomo| |
| Abstract | Urinary tract infections (UTIs) are the most common bacterial infections in women, and many patients experience frequent recurrence. The aim of this report is to introduce an on-going prospective phase II clinical trial performed to evaluate the preventive effectiveness of Lactobacillus vaginal suppositories for prevention of recurrent cystitis. Patients enrolled in this study are administered vaginal suppositories containing the GAI 98322 strain of Lactobacillus crispatus every 2 days or 3 times a week for one year. The primary endpoint is recurrence of cystitis and the secondary endpoints are adverse events. Recruitment began in December 2013 and target sample size is 20 participants. |
| Keywords | probiotics lactobacilli Lactobacillus crispatus urinary tract infection vaginal suppository |
| Amo Type | Clinical Study Protocols |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 299 |
| End Page | 302 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549677 |
| Web of Science KeyUT | 000384748600012 |
| JaLCDOI | 10.18926/AMO/54505 |
|---|---|
| FullText URL | 70_4_285.pdf |
| Author | Tanaka, Takashi| Gobara, Hideo| Inai, Ryota| Iguchi, Toshihiro| Tada, Akihiro| Sato, Shuhei| Yanai, Hiroyuki| Kanazawa, Susumu| |
| Abstract | We present a case of a 66-year-old man with esophageal carcinoma. 18Fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for evaluating distant metastasis and staging revealed 18F-FDG uptake in the third lumbar vertebra and other vertebrae. Magnetic resonance imaging could not differentiate bone metastases from benign bone lesions. We considered the possibility of bone marrow reconversion. 111Indium chloride (111In-Cl3) scintigraphy with single-photon emission computed tomography/computed tomography (SPECT/CT) revealed erythroid bone marrow components in the bone lesions. The diagnosis of bone marrow reconversion was pathologically confirmed by a bone biopsy of the third lumbar vertebra. The patient underwent esophagectomy and has remained disease-free in the 2 years since. To the best of our knowledge, this is the first report to describe the usefulness of 111In-Cl3 with SPECT/CT for the diagnosis of bone marrow reconversion. |
| Keywords | 111Indium chloride scintigraphy SPECT/CT bone marrow reconversion 18F-FDG PET/CT bone metastasis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 289 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549674 |
| Web of Science KeyUT | 000384748600009 |
| JaLCDOI | 10.18926/AMO/54504 |
|---|---|
| FullText URL | 70_4_279.pdf |
| Author | Nishimura, Yoshito| Iwamuro, Masaya| Ocho, Kazuki| Hasegawa, Kou| Kimura, Kosuke| Hanayama, Yoshihisa| Kondo, Eisei| Tanaka, Takehiro| Otsuka, Fumio| |
| Abstract | A 61-year-old Japanese man with IgG4-related autoimmune pancreatitis was referred to our hospital because of perspiration during food intake. Abdominal computed tomography (CT) with contrast media revealed multiple mesenteric lymphadenopathies. An open surgical abdominal biopsy and subsequent histopathological analysis revealed abnormally large lymphoid cells that were negative for CD3, CD5, and c-myc and positive for CD20 and bcl-2, leading to a diagnosis of diffuse large B-cell lymphoma. Here, we discuss the risk of malignancies, particularly malignant lymphoma in patients with IgG4-related disease. The importance of pathological analysis to reach the appropriate diagnosis in such cases should be emphasized. |
| Keywords | IgG4-related disease autoimmune pancreatitis immunophenotyping diffuse large B-cell lymphoma |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 279 |
| End Page | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549673 |
| Web of Science KeyUT | 000384748600008 |
| JaLCDOI | 10.18926/AMO/54503 |
|---|---|
| FullText URL | 70_4_273.pdf |
| Author | Makimoto, Go| Miyahara, Nobuaki| Yoshikawa, Mao| Taniguchi, Akihiko| Kanehiro, Arihiko| Tanimoto, Mitsune| Kiura, Katsuyuki| |
| Abstract | Heerfordtʼs syndrome is a rare manifestation of sarcoidosis and is defined as a combination of facial palsy, parotid swelling, and uveitis, associated with a low-grade fever. We report a case of Heerfordtʼs syndrome presenting with a high fever and increased serum tumor necrosis factor alpha (TNF-α) levels. The patient had facial palsy, parotid swelling, uveitis, and swelling of the right supraclavicular and hilar lymph nodes. Corticosteroid therapy was initiated, and her symptoms soon resolved completely, in tandem with a decrease in TNF-α serum levels. |
| Keywords | Heerfordtʼs syndrome sarcoidosis TNF-α |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 273 |
| End Page | 277 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549672 |
| Web of Science KeyUT | 000384748600007 |
| JaLCDOI | 10.18926/AMO/54501 |
|---|---|
| FullText URL | 70_4_261.pdf |
| Author | Nagata, Kosei| Yamamoto, Shinichi| Miyoshi, Kota| Sato, Masaki| Arino, Yusuke| Mikami, Yoji| |
| Abstract | Eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss syndrome) is a rare systemic vasculitis and is difficult to diagnose. EGPA has a number of symptoms including peripheral dysesthesia caused by mononeuropathy multiplex, which is similar to radiculopathy due to lumbar disc hernia or lumbar spinal stenosis. Therefore, EGPA patients with mononeuropathy multiplex often visit orthopedic clinics, but orthopedic doctors and spine neurosurgeons have limited experience in diagnosing EGPA because of its rarity. We report a consecutive series of patients who were initially diagnosed as having lumbar disc hernia or lumbar spinal stenosis by at least 2 medical institutions from March 2006 to April 2013 but whose final diagnosis was EGPA. All patients had past histories of asthma or eosinophilic pneumonia, and four out of five had peripheral edema. Laboratory data showed abnormally increased eosinophil counts, and nerve conduction studies of all patients revealed axonal damage patterns. All patients recovered from paralysis to a functional level after high-dose steroid treatment. We shortened the duration of diagnosis from 49 days to one day by adopting a diagnostic algorithm after experiencing the first case. |
| Keywords | eosinophilic granulomatosis with polyangiitis mononeuropathy multiplex lumbar disc hernia lumbar spinal stenosis nerve conduction study |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 261 |
| End Page | 268 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549670 |
| Web of Science KeyUT | 000384748600005 |
| JaLCDOI | 10.18926/AMO/54500 |
|---|---|
| FullText URL | 70_4_255.pdf |
| Author | Nosaka, Nobuyuki| Fujiwara, Takeo| Knaup, Emily| Okada, Ayumi| Tsukahara, Hirokazu| |
| Abstract | Estimation methods for pediatric weight have not been evaluated for Japanese children. This study aimed to assess the accuracy of mothersʼ reports of their childrenʼs weight in Japan. We also evaluated potential alternatives to the estimation of weight, including the Broselow tape (BT), Advanced Pediatric Life Support (APLS), and Parkʼs formulae. We prospectively collected cross-sectional data on a convenience sample of 237 children aged less than 10 years who presented to a general pediatric outpatient clinic with their mothers. Each weight estimation method was evaluated using Bland-Altman plots and by calculating the proportion within 10 and 20 of the measured weight. Mothersʼ reports of weight were the most accurate method, with 94.9 within 10 of the measured weight, the lowest mean difference (0.27kg), and the shortest 95 limit of agreement (－1.4 to 1.9kg). The BT was the most reliable alternative, followed by APLS and Parkʼs formulae. Mothersʼ reports of their children ʼs weight are more accurate than other weight estimation methods. When no report of a childʼs weight by the mother is available, BT is the best alternative. When an aged-based formula is the only option, the APLS formula is preferred. |
| Keywords | body weight child estimation techniques mothers, parents |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 255 |
| End Page | 259 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549669 |
| Web of Science KeyUT | 000384748600004 |
| JaLCDOI | 10.18926/AMO/54499 |
|---|---|
| FullText URL | 70_4_243.pdf |
| Author | Osawa, Masahiro| Ohashi, Kadoaki| Kubo, Toshio| Ichihara, Eiki| Takata, Saburo| Takigawa, Nagio| Takata , Minoru| Tanimoto, Mitsune| Kiura, Katsuyuki| |
| Abstract | Vandetanib (ZactimaTM) is a novel, orally available inhibitor of both vascular endothelial growth factor receptor-2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinase. In the present study, a line of transgenic mice with a mouse Egfr gene mutation (delE748-A752) corresponding to a human EGFR mutation (delE746-A750) was established. The transgenic mice developed atypical adenomatous hyperplasia to adenocarcinoma of the lung at around 5 weeks of age and died of lung tumors at approximately 17 weeks of age. In the mice treated with vandetanib (6mg/kg/day), these lung tumors disappeared and the phosphorylations of EGFR and VEGFR-2 were reduced in lung tissues to levels comparable to those of non-transgenic control mice. The median overall survival time of the transgenic mice was 28 weeks in the vandetanib-treated group and 17 weeks in the vehicle-treated group. Vandetanib significantly prolonged the survival of the transgenic mice (log-rank test, p＜0.01); resistance to vandetanib occurred at 20 weeks of age and the animals died from their lung tumors at about 28 weeks of age. These data suggest that vandetanib could suppress the progression of tumors harboring an activating EGFR mutation. |
| Keywords | vandetanib VEGFR EGFR nonsmall cell lung cancer transgenic mouse |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 243 |
| End Page | 253 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549668 |
| Web of Science KeyUT | 000384748600003 |
