result 3074 件
| FullText URL | fulltext.pdf |
|---|---|
| Author | Liu, Yang| Dong, Bo| Yang, Jiajia| Ejima, Yoshimichi| Wu, Jinglong| Wu, Qiong| Zhang, Ming| |
| Keywords | traditional spatial attention paradigm ERP interstimulus interval enhancement and suppression primary somatosensory cortex |
| Published Date | 2021-01-27 |
| Publication Title | Frontiers in Neuroinformatics |
| Volume | volume14 |
| Publisher | Frontiers Media |
| Start Page | 571369 |
| ISSN | 1662-5196 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Liu, Dong, Yang, Ejima, Wu, Wu and Zhang. |
| File Version | publisher |
| PubMed ID | 33584236 |
| DOI | 10.3389/fninf.2020.571369 |
| Web of Science KeyUT | 000616523100001 |
| Related Url | isVersionOf https://doi.org/10.3389/fninf.2020.571369 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yan, Qiujing| Zhao, Liang| Wang, Wenda| Pi, Xiong| Han, Guangye| Wang, Jie| Cheng, Lingpeng| He, Yi-Kun| Kuang, Tingyun| Qin, Xiaochun| Sui, Sen-Fang| Shen, Jian-Ren| |
| Published Date | 2021-02-16 |
| Publication Title | Cell Discovery |
| Volume | volume7 |
| Issue | issue1 |
| Publisher | Springer Nature |
| Start Page | 10 |
| ISSN | 2056-5968 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 33589616 |
| DOI | 10.1038/s41421-021-00242-9 |
| Web of Science KeyUT | 000618354400001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41421-021-00242-9 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamamoto, Haruchika| Sugimoto, Seiichiro| Soh, Junichi| Shiotani, Toshio| Miyoshi, Kentaroh| Otani, Shinji| Okazaki, Mikio| Yamane, Masaomi| Toyooka, Shinichi| |
| Keywords | Prognostic nutrition index Lung allocation score Lung transplantation Living-donor lobar lung transplantation Outcome |
| Note | This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: https://doi.org/10.1007/s00595-021-02244-2.| |
| Published Date | 2021-2-13 |
| Publication Title | Surgery Today |
| Volume | volume51 |
| Publisher | Springer |
| Start Page | 1610 |
| End Page | 1618 |
| ISSN | 0941-1291 |
| NCID | AA10824685 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33582840 |
| DOI | 10.1007/s00595-021-02244-2 |
| Web of Science KeyUT | 000617830200001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00595-021-02244-2 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ikeda, Tomoka| Gion, Yuka| Nishimura, Yoshito| Nishimura, Midori Filiz| Yoshino, Tadashi| Sato, Yasuharu| |
| Keywords | EBV-positive mucocutaneous ulcer clinical features pathological features immunosuppression |
| Published Date | 2021-01-21 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume22 |
| Issue | issue3 |
| Publisher | MDPI |
| Start Page | 1053 |
| ISSN | 1422-0067 |
| NCID | AA12038549 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33494358 |
| DOI | 10.3390/ijms22031053 |
| Web of Science KeyUT | 000615330100001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms22031053 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ito, Atene| Kagawa, Shunsuke| Sakamoto, Shuichi| Kuwada, Kazuya| Kajioka, Hiroki| Yoshimoto, Masashi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | Extracellular vesicles Gastric cancer Tumor-associated macrophages Tumor microenvironment |
| Published Date | 2021-01-28 |
| Publication Title | BMC Cancer |
| Volume | volume21 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 102 |
| ISSN | 1471-2407 |
| NCID | AA12034763 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2021 |
| File Version | publisher |
| PubMed ID | 33509150 |
| DOI | 10.1186/s12885-021-07816-6 |
| Web of Science KeyUT | 000615987400002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12885-021-07816-6 |
| JaLCDOI | 10.18926/AMO/61441 |
|---|---|
| FullText URL | 75_1_103.pdf |
| Author | Senoo, Mayumi| Tone, Atsuhito| Imai, Yusuke| Watanabe, Satoko| Kaneto, Mitsuhiro| Shimomura, Yasuyuki| Teshigawara, Sanae| Nakatou, Tatsuaki| |
| Abstract | A 43-year-old male with type 2 diabetes, under treatment with 5 mg/day of dapagliflozin, was referred to our hospital with upper left abdominal pain and marked hypertriglyceridemia (triglycerides [TGs], 5,960 mg/dl). He was also on a low-carbohydrate diet that promoted ketosis under sodium glucose cotransporter 2 (SGLT2) inhibitor administration. Polyacrylamide gel electrophoresis revealed a remarkable increase in very-low-den-sity lipoprotein, a TG-rich lipoprotein particle synthesized in the liver using free fatty acids derived from adi-pose tissue. Although SGLT2 inhibitors generally improve the lipid profile, under certain conditions such as a low-carbohydrate diet, they may adversely exacerbate the lipid profile via ketosis. |
| Keywords | sodium glucose cotransporter 2 inhibitor dyslipidemia hypertriglyceridemia type 2 diabetes mellitus |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 103 |
| End Page | 107 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649621 |
| JaLCDOI | 10.18926/AMO/61438 |
|---|---|
| FullText URL | 75_1_79.pdf |
| Author | Yoshio, Kotaro| Nagasaka, Hisako| Hisazumi, Kento| Okawa, Hiro| Tajiri, Nobuhisa| Shiode, Tsuyoki| Akaki, Shiro| Kanazawa, Susumu| Mitoma, Tomohiro| Yano, Yuri| Kobayashi, Emiko| Horiguchi, Ikuyo| Takata, Masayo| Hongo, Atsushi| Yonezawa, Masaru| Nakanishi, Yoshie| |
| Abstract | The purposes of this retrospective study were to analyze local control of squamous cell carcinoma of the cervix treated with computed tomography (CT)-based image-guided brachytherapy (IGBT), as well as the factors affecting local control. A total of 39 patients were analyzed. The prescribed dose to the pelvis was 45-50 Gy with or without central shielding (CS). IGBT was delivered in 1-5 fractions. The total dose for high-risk clinical target volume (HR-CTV) was calculated as the biologically equivalent dose in 2-Gy fractions. The median follow-up period was 29.3 months. The 2-year overall survival and local control rates were 97% and 91%, respectively. In univariate analysis, the dose covering 90% of the HR-CTV (D90) and tumor size were found to be significant factors for local control. The cutoff values of tumor size and D90 for local control were 4.3 cm (area under the curve [AUC] 0.75) and 67.7 Gy (AUC 0.84) in the CS group and 5.3 cm (AUC 0.75) and 73.7 Gy (AUC 0.78) in the group without CS, respectively. However, though the local control of CT-based IGBT was favorable, the results suggested that the dose required for tumor control may differ depending on the presence of CS. |
| Keywords | cervical cancer squamous cell cancer brachytherapy central shielding |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 79 |
| End Page | 85 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649617 |
| JaLCDOI | 10.18926/AMO/61431 |
|---|---|
| FullText URL | 75_1_31.pdf |
| Author | Miyamaru, Satoru| Murakami, Daizo| Nishimoto, Kohei| Saito, Haruki| Miyamoto, Yusuke| Hirota, Kaoruko| Ise, Momoko| Orita, Yorihisa| |
| Abstract | Although the lung is the most common site of distant metastases from head and neck squamous cell carcinoma (HNSCC), the number of reports about the effects of pulmonary metastasectomy for the treatment of lung metastasis from HNSCC is limited. Metachronous pulmonary metastases were detected in 45 HNSCC patients at Kumamoto University Hospital from 1998 to 2018. Twenty-two patients underwent an operative resection (Ope group) and 23 underwent chemotherapy (Chemo group). The 3-year overall survival (OS) rate and median OS were evaluated. The effects of adjuvant chemotherapy after pulmonary metastasectomy and of new drugs (cetuximab and nivolumab), in the chemo group were also assessed. The 3-year OS rates and median OS were: Ope, 66.1% and 31.5 months; Chemo, 39.7% and 18 months, respectively. In the Ope group, addi-tional recurrences were significantly fewer in the patients who underwent adjuvant chemotherapy post-surgery versus the patients who underwent surgery alone (p = 0.013). In the Chemo group, the 3-year OS rate of the patients who received new drugs was significantly better than that of the patients who did not (p = 0.021). Adjuvant chemotherapy after pulmonary metastasectomy may be a preferable treatment option for preventing recurrences. Cetuximab and nivolumab have a potential to improve OS. |
| Keywords | pulmonary metastasis head and neck squamous cell carcinoma pulmonary metastasectomy adjuvant chemotherapy |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 31 |
| End Page | 37 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649611 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sasaki, Ryo| Yamashita, Toru| Omote, Yoshio| Takemoto, Mami| Hishikawa, Nozomi| Yunoki, Taijun| Kobayashi, Kazuki| Sawata, Takashi| Sato, Yuki| Kubota, Junichi| Mizobuchi, Masayuki| Hayashi, Takashi| Abe, Koji| |
| Keywords | COVID‐19 Okayama skype telemedicine telestroke |
| Note | This is the peer reviewed version of the following article: Ryo Sasaki et. al. A new telestroke network system in northern area of Okayama prefecture (2020), which has been published in final form at https://doi.org/10.1111/ncn3.12475. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| |
| Published Date | 2020-12-14 |
| Publication Title | Neurology and Clinical Neuroscience |
| Volume | volume9 |
| Issue | issue2 |
| Publisher | Wiley |
| Start Page | 166 |
| End Page | 170 |
| ISSN | 2049-4173 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| DOI | 10.1111/ncn3.12475 |
| Web of Science KeyUT | 000614519300001 |
| Related Url | isVersionOf https://doi.org/10.1111/ncn3.12475 |
| JaLCDOI | 10.18926/AMO/61424 |
|---|---|
| FullText URL | 75_1_1.pdf |
| Author | Hamahara, Jun| Honda, Hiroyuki| Yamamoto, Koichiro| Tokumasu, Kazuki| Hanayama, Yoshihisa| Hagiya, Hideharu| Obika, Mikako| Ueda, Keigo| Kishida, Masayuki| Otsuka, Fumio| |
| Abstract | To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = −0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males. |
| Keywords | androgen diabetes mellitus late-onset hypogonadism testosterone thyroid function |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-02 |
| Volume | volume75 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 33649607 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sato, Keita| Nwe, Khine Nwe| Ohuchi, Hideyo| |
| Keywords | medaka nonimage‐forming photoreception opn3 opsin tmt‐opsin RRID:SCR_018163 RRID:SCR_003070 RRID:SCR_005887 RRID:SCR_004860 RRID:SCR_010279 RRID:AB_2336524 RRID:AB_514497 RRID:AB_514504 RRID:AB_2339038 RRID: AB_840257 |
| Note | This is the peer reviewed version of the following article: [Sato, K, , KNN, Ohuchi, H. The Opsin 3/Teleost multiple tissue opsin system: mRNA localization in the retina and brain of medaka (Oryzias latipes). J Comp Neurol. 2021; 529: 2484– 2516. https://doi.org/10.1002/cne.25106], which has been published in final form at [https://doi.org/10.1002/cne.25106]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages there of by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.| |
| Published Date | 2021-01-11 |
| Publication Title | Journal of Comparative Neurology |
| Volume | volume529 |
| Publisher | Wiley |
| Start Page | 2484 |
| End Page | 2516 |
| ISSN | 0021-9967 |
| NCID | AA00695917 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Wiley Periodicals LLC |
| File Version | author |
| PubMed ID | 33427299 |
| DOI | 10.1002/cne.25106 |
| Web of Science KeyUT | 000611189900001 |
| Related Url | isVersionOf https://doi.org/10.1002/cne.25106 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yano, Shuya| Tazawa, Hiroshi| Kishimoto, Hiroyuki| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| Hoffman, Robert M.| |
| Keywords | cancer cell cycle fluorescent proteins FUCCI imaging adenovirus oncolytic virotherapy cancer stem cell mouse model orthotopic |
| Published Date | 2021-01-17 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume22 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 879 |
| ISSN | 1422-0067 |
| NCID | AA12038549 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 by the authors. |
| File Version | publisher |
| PubMed ID | 33477279 |
| DOI | 10.3390/ijms22020879 |
| Web of Science KeyUT | 000611296000001 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms22020879 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Sivixay, Souliphone| Bai, Gaowa| Tsuruta, Takeshi| Nishino, Naoki| |
| Keywords | diet gut microbiota protein prebiotics |
| Published Date | 2021-01-14 |
| Publication Title | AIMS Microbiology |
| Volume | volume7 |
| Issue | issue1 |
| Publisher | AIMS Press |
| Start Page | 1 |
| End Page | 12 |
| ISSN | 2471-1888 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 the Author(s) |
| File Version | publisher |
| DOI | 10.3934/microbiol.2021001 |
| Web of Science KeyUT | 000608483600001 |
| Related Url | isVersionOf https://doi.org/10.3934/microbiol.2021001 |
| FullText URL | 2020 06 Ono K triple kd JEV.pdf |
|---|---|
| Author | Ono, Kisho| Sogawa, Chiharu| Kawai, Hotaka| Manh Tien Tran| Taha, Eman A.| Lu, Yanyin| May Wathone Oo| Okusha, Yuka| Okamura, Hirohiko| Ibaragi, Soichiro| Takigawa, Masaharu| Kozaki, Ken-Ichi| Nagatsuka, Hitoshi| Sasaki, Akira| Okamoto, Kuniaki| Calderwood, Stuart K.| Eguchi, Takanori| |
| Keywords | Extracellular vesicles epithelial‐mesenchymal transition tumour‐associated macrophage CDC37 HSP90 tetraspanin oral cancer |
| Published Date | 2020-05-31 |
| Publication Title | Journal of Extracellular Vesicles |
| Volume | volume9 |
| Issue | issue1 |
| Publisher | Taylor & Francis |
| Start Page | 1769373 |
| ISSN | 2001-3078 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s). |
| File Version | publisher |
| PubMed ID | 33144925 |
| DOI | 10.1080/20013078.2020.1769373 |
| Related Url | isVersionOf https://doi.org/10.1080/20013078.2020.1769373 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ishida, Hisashi| Iguchi, Akihiro| Aoe, Michinori| Nishiuchi, Ritsuo| Matsubara, Takehiro| Keino, Dai| Sanada, Masashi| Shimada, Akira| |
| Keywords | leukemia pediatric acute myeloid leukemia molecular genetics precision medicine |
| Published Date | 2020-11 |
| Publication Title | Biomedical Reports |
| Volume | volume13 |
| Issue | issue5 |
| Publisher | Spandidos Publications |
| Start Page | 46 |
| ISSN | 2049-9434 |
| NCID | AA12610729 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| PubMed ID | 32934818 |
| DOI | 10.3892/br.2020.1353 |
| Web of Science KeyUT | 000606302400012 |
| Related Url | isVersionOf https://doi.org/10.3892/br.2020.1353 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kajiwara, Koichiro| Sawa, Yoshihiko| Fujita, Takahiro| Tamaoki, Sachio| |
| Keywords | P. gingivalis LPS Diabetic nephropathy VCAM-1 E-selectin ACE2 FGF23 |
| Published Date | 2021-01-06 |
| Publication Title | BMC Nephrology |
| Volume | volume22 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 3 |
| ISSN | 1471-2369 |
| NCID | AA12035314 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 33407253 |
| DOI | 10.1186/s12882-020-02203-y |
| Web of Science KeyUT | 000608270800002 |
| Related Url | isVersionOf https://doi.org/10.1186/s12882-020-02203-y |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Funahashi, Hiroaki| |
| Note | International Conference: Improving Tropical Animal Production for Food Security 22-24 November 2019, South East Sulawesi, Indonesia| |
| Published Date | 2020 |
| Publication Title | IOP Conference Series: Earth and Environmental Science |
| Volume | volume465 |
| Publisher | IOP Publishing |
| Start Page | 012001 |
| ISSN | 1755-1307 |
| Content Type | Conference Paper |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| DOI | 10.1088/1755-1315/465/1/012001 |
| Web of Science KeyUT | 000607205000001 |
| Related Url | isVersionOf https://doi.org/10.1088/1755-1315/465/1/012001 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Miki, Tomoko| Yokota, Osamu| Haraguchi, Takashi| Ishizu, Hideki| Hasegawa, Masato| Ishihara, Takeshi| Ueno, Shu‐ichi| Takenoshita, Shintaro| Terada, Seishi| Yamada, Norihito| |
| Keywords | aging‐related tau astrogliopathy argyrophilic grain granular/fuzzy astrocyte primary age‐related tauopathy tau tufted astrocyte |
| Published Date | 2020-04-15 |
| Publication Title | Brain Pathology |
| Volume | volume30 |
| Issue | issue4 |
| Publisher | Wiley |
| Start Page | 811 |
| End Page | 830 |
| ISSN | 1015-6305 |
| NCID | AA10776221 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32293067 |
| DOI | 10.1111/bpa.12843 |
| Web of Science KeyUT | 000530564500001 |
| Related Url | isVersionOf https://doi.org/10.1111/bpa.12843 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | YASUHARA, Takao| MURAI, Satoshi| MIKUNI, Nobuhiro| MIYAMOTO, Susumu| DATE, Isao| |
| Keywords | artificial bone cranioplasty infection re-operation titanium plate |
| Published Date | 2020 |
| Publication Title | Neurologia medico-chirurgica |
| Volume | volume60 |
| Issue | issue7 |
| Publisher | The Japan Neurosurgical Society |
| Start Page | 337 |
| End Page | 350 |
| ISSN | 0470-8105 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by The Japan Neurosurgical Society |
| PubMed ID | 32536658 |
| DOI | 10.2176/nmc.oa.2020-0051 |
| Web of Science KeyUT | 000548315700003 |
| Related Url | isVersionOf https://doi.org/10.2176/nmc.oa.2020-0051 |
| Title Alternative | A comparative gene analysis reveals a diatom-specific SET domain protein family |
|---|---|
| FullText URL | srfa_110_001_006.pdf |
| Author | Nemoto, Michiko| |
| Abstract | The silica cell walls of diatoms, which exhibit species-spe-cific micro- and nano- patterned structures are promising candidates for applications in nanotechnology. Previous studies revealed a number of silica cell wall-associated proteins involved in silica formation. However, molecular biological analyses toward understanding of diatom cell wall formation have been mostly limited to model diatom species and general silica formation process in diatoms is still incompletely understood. In this study, to gain a compre-hensive insight into diatom silica biomineralization, tran-scriptome data of three diatom species, Nitzschia palea, Achnanthes kuwaitensis and Pseudoleyanella lunata, were newly developed. The reads obtained from RNA sequencing were assembled into 31,946, 60,767 and 38,314 unique transcripts for N. palea, A. kuwaitensis and P. lunata, respectively. In order to identify the diatom-specific genes, three transcriptome data sets developed in this study and the protein-coding gene sets of five genome-sequenced diatoms were compared. The proteins shared only by eight diatom species that are predicted to possess an endoplasmic reticulum (ER)-targeting signal peptide were selected for further analyses. These include proteins showing homology to silicanin-1, a recently reported diatom-specific protein involved in silica formation, as well as a number of SET domain proteins. The SET domain proteins might be novel diatom-specific family of methyltransferases that may reg-ulate the function of silica formation related proteins or long chain polyamines. The genes encoding the diatom-specific SET domain proteins identified in this study, which were shown to respond to silicon were suggested to be implicated in silica biomineralization. |
| Keywords | Biomineralization Diatom Silica Protein |
| Publication Title | Scientific Reports of the Faculty of Agriculture, Okayama University |
| Published Date | 2021-02-01 |
| Volume | volume110 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 2186-7755 |
| language | Japanese |
| File Version | publisher |
| NAID | 120006955817 |
