result 2801 件
| FullText URL | K0005739_abstract_review.pdf K0005739_fulltext.pdf |
|---|---|
| Author | Mitogawa, Kazumasa| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5739号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005737_abstract_review.pdf K0005737_fulltext.pdf |
|---|---|
| Author | Fujiwara, Yuya| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5737号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005735_abstract_review.pdf K0005735_fulltext.pdf |
|---|---|
| Author | Kazi Mostafijur Rahman| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5735号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005733_abstract_review.pdf K0005733_fulltext.pdf |
|---|---|
| Author | Nishikawa, Kotaro| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5733号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005731_abstract_review.pdf K0005731_fulltext.pdf |
|---|---|
| Author | Myo Myint| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5731号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005729_abstract_review.pdf K0005729_fulltext.pdf |
|---|---|
| Author | Khin Khin Zaw| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5729号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005724_abstract_review.pdf K0005724_fulltext.pdf |
|---|---|
| Author | Tanaka, Kenta| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5724号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005723_abstract_review.pdf K0005723_fulltext.pdf |
|---|---|
| Author | Nakamura, Tsutomu| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5723号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005712_abstract_review.pdf K0005712_summary.pdf K0005712_fulltext.pdf K0005712_orher1.pdf |
|---|---|
| Author | Kato, Seiya| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5712号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005705_abstract_review.pdf K0005705_summary.pdf K0005705_fulltext.pdf K0005705_orher1.pdf |
|---|---|
| Author | Kunitomi, Yosuke| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5705号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005701_abstract_review.pdf K0005701_summary.pdf K0005701_fulltext.pdf K0005701_orher1.pdf |
|---|---|
| Author | Osaka, Suguru| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5701号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005692_abstract_review.pdf K0005692_summary.pdf K0005692_fulltext.pdf |
|---|---|
| Author | Tashiro, Haruki| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5692号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Dental Science |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005686_abstract_review.pdf K0005686_summary.pdf K0005686_fulltext.pdf K0005686_fig.pdf |
|---|---|
| Author | Nishiyama, Yuki| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5686号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005677_abstract_review.pdf K0005677_summary.pdf K0005677_fulltext.pdf K0005677_other.pdf |
|---|---|
| Author | Hasegawa, Toru| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5677号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005662_abstract_review.pdf K0005662_summary.pdf K0005662_fulltext.pdf |
|---|---|
| Author | Matoba, Ryo| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5662号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005660_abstract_review.pdf K0005660_summary.pdf K0005660_fulltext.pdf K0005660_fig.pdf |
|---|---|
| Author | Horita, Masahiro| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5660号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005647_abstract_review.pdf K0005647_summary.pdf K0005647_fulltext.pdf |
|---|---|
| Author | Yoshida, Aki| |
| Published Date | 2018-03-23 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5647号 |
| Granted Date | 2018-03-23 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/AMO/55857 |
|---|---|
| FullText URL | 72_2_165.pdf |
| Author | Yoshida, Aki| Fujiwara, Tomohiro| Uotani, Koji| Morita, Takuya| Kiyono, Masahiro| Yokoo, Suguru| Hasei, Joe| Nakata, Eiji| Kunisada, Toshiyuki| Ozaki, Toshifumi| |
| Abstract | Although there is considerable evidence indicating that the dysregulation of microRNAs (miRNAs) in malignant tumors plays a role in tumor development, the overall function of miRNAs and their clinicopathological significance are not well understood. In this retrospective analysis of 45 biopsy specimens from osteosarcoma (OS) patients, we investigated the functional and clinical significance of miR-25-3p in OS, which we previously identified as a highly expressed miRNA in OS patients’ serum. We observed that miR-25-3p dysregulation in human OS tissues was negatively correlated with the clinical prognosis, whereas the expression level of its target gene, Dickkopf WNT Signaling Pathway Inhibitor 3 (DKK3), was positively correlated with the clinical prognosis. Endogenous miR-25-3p upregulation promoted tumor growth, invasion, and drug resistance, which was consistent with DKK3 silencing in OS cells. In addition, secretory miR-25-3p was embedded in tumor-derived exosomes, where it promoted capillary formation and the invasion of vascular endothelial cells. Overall, our results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in OS, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease. |
| Keywords | microRNA circulating microRNA osteosarcoma prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2018-04 |
| Volume | volume72 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 165 |
| End Page | 174 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2018 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29674765 |
| FullText URL | cted_008.pdf |
|---|---|
| Author | 岡山大学教師教育開発センター| |
| Publication Title | Bulletin of Center for Teacher Education and Development, Okayama University |
| Published Date | 2018-03-20 |
| Volume | volume8 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2018 岡山大学教師教育開発センター |
| File Version | publisher |
| JaLCDOI | 10.18926/OER/55750 |
|---|---|
| Title Alternative | Development of the External Economic Policies in China : Reforms of Foreign Trade System, Opening of the whole area to the world |
| FullText URL | oer_049_3_163_183.pdf |
| Author | Teng, Jian| |
| Publication Title | Okayama Economic Review |
| Published Date | 2018-03-19 |
| Volume | volume49 |
| Issue | issue3 |
| Start Page | 163 |
| End Page | 183 |
| ISSN | 2433-4146 |
| language | Japanese |
| Copyright Holders | Copyright © 2018 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120006414159 |
