result 23633 件
| JaLCDOI | 10.18926/AMO/53521 |
|---|---|
| FullText URL | 69_3_145.pdf |
| Author | Ishii, Hiroko| Kamikawa, Shigeshi| Hirohata, Satoshi| Mizutani, Akifumi| Abe, Koji| Seno, Masaharu| Oohashi, Toshitaka| Ninomiya, Yoshifumi| |
| Abstract | Eosinophil cationic protein (ECP) is well known as a cationic protein contained in the basic granules of activated eosinophils. Recent studies have reported that ECP exhibits novel activities on various types of cells, including rat neonatal cardiomyocytes. Here we evaluated the effects of ECP on rat cardiac myoblast H9c2 cells. Our results showed that ECP enhanced the survival of the cells, in part by promoting the ERK and Akt/GSK-3β signaling pathways. ECP attenuated the cytotoxic effects of H2O2 on H9c2 cells as well as the production of reactive oxygen species, the number of apoptotic cells and caspase 3/7 activity in the cells. In conclusion, ECP activated the ERK and Akt/GSK-3β pathways, resulting in anti-oxidative effects on H9c2 cells that attenuated apoptosis. |
| Keywords | ECP reactive oxygen species Akt ERK |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 145 |
| End Page | 153 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101190 |
| Web of Science KeyUT | 000356903000003 |
| JaLCDOI | 10.18926/AMO/53520 |
|---|---|
| FullText URL | 69_3_137.pdf |
| Author | Seki, Hiroyuki| Ikeda, Fusao| Nanba, Shintaro| Moritou, Yuki| Takeuchi, Yasuto| Yasunaka, Tetsuya| Onishi, Hideki| Miyake, Yasuhiro| Takaki, Akinobu| Nouso, Kazuhiro| Iwasaki, Yoshiaki| Nakamura, Minoru| Yamamoto, Kazuhide| |
| Abstract | A predictive marker of the rapid progression to hepatic failure is desired for patients with asymptomatic primary biliary cirrhosis (aPBC). We performed a systematic cohort analysis of 101 patients diagnosed as having aPBC and the rapid progression to liver failure in some, by focusing on cholestasis. Cholestasis was assessed by aberrant keratin7 (K-7) expressions in the patientsʼ hepatocytes. Intralobular expressions of K-7 were found in 9 of the 101 patients. The grades of K-7 expression were significantly associated with the levels of alanine aminotransferase, alkaline phosphatase, and total bilirubin at the time of diagnosis, but not with bile duct loss or cholestasis. Stepwise logistic regression analysis revealed that high grades of K-7 expression correlated positively with high levels of total bilirubin. During the follow-up period, 8 patients developed jaundice, and the mean period until the development of jaundice was 5.2 years. The proportional hazards models for the risk of developing jaundice identified a high grade of aberrant K-7 expression in hepatocytes as the only significant risk factor. Aberrant K-7 expression in hepatocytes can be used as an additional marker to predict rapid progression to liver failure in patients with aPBC at the time of diagnosis. |
| Keywords | primary biliary cirrhosis keratin 7 hepatic failure |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 137 |
| End Page | 144 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101189 |
| Web of Science KeyUT | 000356903000002 |
| JaLCDOI | 10.18926/AMO/53519 |
|---|---|
| FullText URL | 69_3_129.pdf |
| Author | Akagi, Satoshi| Nakamura, Kazufumi| Matsubara, Hiromi| Ogawa, Aiko| Sarashina, Toshihiro| Ejiri, Kentaro| Ito, Hiroshi| |
| Abstract | Pulmonary arterial hypertension (PAH) is characterized by elevation of pulmonary artery pressure caused by pulmonary vasoconstriction and vascular remodeling, which leads to right heart failure and death. Epoprostenol (prostaglandin I2) has a potent short-acting vasodilator property, and intravenous continuous epoprostenol is therefore used for treatment of PAH. Here we review evidence for the usefulness of intravenous continuous epoprostenol therapy in patients with PAH. Epoprostenol therapy is effective in idiopathic PAH patients and in patients with PAH associated with connective tissue disease, portal hypertension or congenital heart diseases, but it is not effective in patients with pulmonary veno-occlusive disease or pulmonary capillary hemangiomatosis. High-dose epoprostenol therapy markedly improved hemodynamics in some patients with PAH, possibly due to reverse remodeling of pulmonary arteries. This therapy has several side effects and complications such as headache, hypotension and catheter-related infections. Intravenous continuous epoprostenol is an effective treatment, but there are still some problems to be resolved. |
| Keywords | pulmonary arterial hypertension epoprostenol high-dose complications side effects |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 129 |
| End Page | 136 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101188 |
| Web of Science KeyUT | 000356903000001 |
| Author | Zamami, Yoshito| Takatori, Shingo| Goda, Mitsuhiro| Koyama, Toshihiro| Iwatani, Yukiko| Jin, Xin| Takada-Doi, Shima| Kawasaki, Hiromu| |
|---|---|
| Published Date | 2008-11-01 |
| Publication Title | Biological & Pharmaceutical Bulletin |
| Volume | volume31 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Zamami, Yoshito| Takatori, Shingo| Koayama, Toshihiro| Goda, Mitsuhiro| Iwatani, Yukiko| Doi, Shima| Kawasaki, Hiromu| |
|---|---|
| Published Date | 2007-12-01 |
| Publication Title | 藥學雜誌 |
| Volume | volume127 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Zamami, Yoshito| Takatori, Shingo| Iwatani, Yukiko| Yamawaki, Kosuke| Miyashita, Satoko| Yabumae, Nana| Takayama, Fusako| Mio, Mitsunobu| Kawasaki, Hiromu| |
|---|---|
| Published Date | 2008-03-01 |
| Publication Title | 藥學雜誌 |
| Volume | volume128 |
| Issue | issue3 |
| Content Type | Journal Article |
| Author | Zamami, Yoshito| Fujiwara, Hiroki| Hosoda, Miho| Hino, Hayato| Hirai, Kazuhiro| Okamoto, Kazuaki| 金 鑫| 高取 真吾| 高木 志真| Kawasaki, Hiromu| |
|---|---|
| Published Date | 2010-06-01 |
| Publication Title | 藥學雜誌 |
| Volume | volume130 |
| Issue | issue6 |
| Content Type | Journal Article |
| Author | 全 成坤| |
|---|---|
| Published Date | 2014-03-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume21 |
| Content Type | Research Paper |
| Author | 宋 浣範| |
|---|---|
| Published Date | 2014-03-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume21 |
| Content Type | Research Paper |
| Author | Suzuki, Michitaka| |
|---|---|
| Published Date | 2014-03-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume21 |
| Content Type | Research Paper |
| Author | Watanabe, Yoshinari| |
|---|---|
| Published Date | 2014-03-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume21 |
| Content Type | Research Paper |
| Author | Yusa, Toru| |
|---|---|
| Published Date | 2014-03-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume21 |
| Content Type | Research Paper |
| Author | Watanabe, Yoshinari| |
|---|---|
| Published Date | 2015-03-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22-2 |
| Content Type | Research Paper |
| Author | Suzuki, Michitaka| |
|---|---|
| Published Date | 2015-03-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22-2 |
| Content Type | Research Paper |
| Author | 岡山大学文学部| |
|---|---|
| Published Date | 2015-03-31 |
| Publication Title | 岡山大学文学部プロジェクト研究報告書 |
| Volume | volume22-2 |
| Content Type | Others |
| Author | Hanaya, Tadashi| Ito, Kasumi| |
|---|---|
| Published Date | 2014-04 |
| Publication Title | Heterocycles |
| Volume | volume88 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Okayama Association for Laboratory Animal Science| |
|---|---|
| Published Date | 2015-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume31 |
| Content Type | Others |
| Author | Okayama Association for Laboratory Animal Science| |
|---|---|
| Published Date | 2015-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume31 |
| Content Type | Others |
| Published Date | 2015-04 |
|---|---|
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume31 |
| Content Type | Others |
| Author | Usuda, Toshiki| Furumoto, Kayo| Kita, Megumu| |
|---|---|
| Published Date | 2015-04 |
| Publication Title | 岡山実験動物研究会報 |
| Volume | volume31 |
| Content Type | Journal Article |
