| ID | 40756 |
| FullText URL | |
| Title Alternative | Studies of the treatment of pulmonary epidermoid carcinoma Part 2. Thermochemotherapy in human epidermoid carcinoma cells in culture
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| Author |
Seto, Takumi
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| Abstract | The effectiveness of hyperthermia in combination with anticancer drugs on EBC-1 cell line established from a patient with pulmonary epidermoid carcinoma was investigated. Anticancer drugs tested in the present study were adriamycin, bleomycin, cisdichlorodiammineplatinum (II) and mitomycin C. EBC-1 cells were incubated with the drug for one hour at 37°C or at elevated temperature (41°C, 42°C and 43°C). The enhancement of cytotoxicity by hyperthermia was found in combination with all of the drugs. The degree of enhanced cytotoxicity was positively elated to the temperature in combinations with adriamycin and bleomycin. Especially, a synergic enhancement of cytotoxicity was found with the combination of hyperthermia and bleomycin. The present study showed that the combination of hyperthermia and anticancer drugs produced potential cytotoxicity on EBC-1 cells in vitro, and may provide useful information for the clinical trials in the future.
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| Keywords | human lung cancer cell line
thermochemotherapy
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| Published Date | 1989-06
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume101
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| Issue | issue5-6
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 581
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| End Page | 588
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/101/5-6/101_5-6_581/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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