Conditions

close

result 11275 件

FullText URL K0007180_abstract_review.pdf K0007180_fulltext.pdf K0007180_summary.pdf
Author DEMIYA, Koji|
Published Date 2025-03-25
Content Type Thesis or Dissertation
Grant Number 甲第7180号
Granted Date 2025-03-25
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
Copyright Holders © 2024 The Authors.
FullText URL fulltext.pdf
Author Tomita, Yusuke| Otani, Yoshihiro| Omae, Ryo| Mizuta, Ryo| Ishida, Joji| Hirotsune, Nobuyuki| Tanaka, Shota|
Keywords glioblastoma long-term survivor SEER short-term survivor United States
Published Date 2025-02-09
Publication Title Neuro-Oncology Advances
Volume volume7
Issue issue1
Publisher Oxford University Press (OUP)
Start Page vdaf036
ISSN 2632-2498
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
PubMed ID 40376679
DOI 10.1093/noajnl/vdaf036
Web of Science KeyUT 001488411400001
Related Url isVersionOf https://doi.org/10.1093/noajnl/vdaf036
FullText URL fulltext.pdf
Author Haratake, Tomoka| Nishimura, Midori Filiz| Nishikori, Asami| Gonzalez, Michael V.| Ennishi, Daisuke| Lai, You Cheng| Ochi, Sayaka| Tsunoda, Manaka| Fajgenbaum, David C.| van Rhee, Frits| Momose, Shuji| Sato, Yasuharu|
Keywords idiopathic multicentric Castleman disease integrin subunit alpha 5 PI3K–Akt signaling pathway platelet-derived growth factor receptor beta vascular endothelial growth factor A vascularity
Published Date 2025-08
Publication Title Modern Pathology
Volume volume38
Issue issue8
Publisher Elsevier BV
Start Page 100782
ISSN 0893-3952
NCID AA1067307X
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 THE AUTHORS.
File Version publisher
PubMed ID 40274066
DOI 10.1016/j.modpat.2025.100782
Web of Science KeyUT 001491556800003
Related Url isVersionOf https://doi.org/10.1016/j.modpat.2025.100782
FullText URL fulltext.pdf
Author Abe, Masaya| Fujii, Keiko| Mitsuhashi, Toshiharu| Kitamura, Wataru| Ikeuchi, Kazuhiro| Fukumi, Takuya| Washio, Kana| Otsuka, Fumio| Maeda, Yoshinobu| Fujii, Nobuharu|
Keywords anticoagulant apheresis high sodium citrate concentration Spectra Optia
Published Date 2025-05-19
Publication Title Transfusion
Publisher Wiley
ISSN 0041-1132
NCID AA00868753
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40387021
DOI 10.1111/trf.18280
Web of Science KeyUT 001490160900001
Related Url isVersionOf https://doi.org/10.1111/trf.18280
FullText URL fulltext.pdf
Author Kato, Koji| Kumazawa, Minoru| Nakajima, Yoshiki| Suzuki, Takehiro| Dohmae, Naoshi| Shen, Jian-Ren| Ifuku, Kentaro| Nagao, Ryo|
Published Date 2025-05-16
Publication Title Science Advances
Volume volume11
Issue issue20
Publisher American Association for the Advancement of Science
Start Page eadv7488
ISSN 2375-2548
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.
File Version publisher
PubMed ID 40378202
DOI 10.1126/sciadv.adv7488
Web of Science KeyUT 001489655000004
Related Url isVersionOf https://doi.org/10.1126/sciadv.adv7488
FullText URL fulltext.pdf
Author La Rocca, Romain| Kato, Koji| Tsai, Pi-Cheng| Nakajima, Yoshiki| Akita, Fusamichi| Shen, Jian-Ren|
Published Date 2025-05-05
Publication Title Nature Communications
Volume volume16
Issue issue1
Publisher Nature Portfolio
Start Page 4175
ISSN 2041-1723
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40325014
DOI 10.1038/s41467-025-59512-9
Web of Science KeyUT 001482932500018
Related Url isVersionOf https://doi.org/10.1038/s41467-025-59512-9
JaLCDOI 10.18926/AMO/68730
FullText URL 79_3_213.pdf
Author Watanabe, Makoto| Ogawa, Tomoyuki| Kobayashi, Kanao| Katsuya, Narutaka| Ishikawa, Akira| Hamamoto, Takao| Tahara, Hiroaki| Ueda, Tsutomu| Takeno, Sachio|
Abstract Renal cell carcinoma (RCC) can metastasize hematogenously and recur after a long dormancy. Chromophobe RCC metastasized to the cervical lymph nodes 10 years after the primary resection in a woman who underwent nephrectomy for RCC (T1aN0M0 stage I). Metastatic RCC diagnosis was confirmed by aspiration. The lymph node mass was resected, and the tumor cells matched chromophobe RCC metastasis. No adjuvant therapy was administered due to the lack of evidence regarding adjuvant therapy for chromophobe RCC. Long-term surveillance is crucial in RCC because of the possibility of late metastasis. We reviewed the clinical aspects and literature on metastatic cervical RCC.
Keywords renal cell carcinoma cervical lymph node metastasis late recurrence head and neck
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 213
End Page 219
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574261
Web of Science KeyUT 001524768800009
JaLCDOI 10.18926/AMO/68729
FullText URL 79_3_209.pdf
Author Taguchi, Kenichi| Nishii, Kazuya| Hata, Sakura| Kuyama, Shoichi| Tanaka, Shoichi|
Abstract A 38-year-old man was brought to the hospital for emergency treatment of cyanosis. The patient exhibited generalized cyanosis and impaired consciousness despite adequate oxygen therapy. Arterial blood was black, and arterial blood gas analysis revealed an abnormally high methemoglobin level of 67.8%. We later interviewed his colleagues regarding his exposure to aniline while working at the factory and diagnosed him with methemoglobinemia due to aniline poisoning. The patient was administered methylene blue (MB) after being transferred to another hospital, where this treatment was available, resulting in an improvement in symptoms. Although rare, methemoglobinemia is serious. A good understanding of the circumstances at disease onset, characteristic findings, and abnormal values of methemoglobinemia is important. In addition, MB is an important therapeutic for the treatment of methemoglobinemia; if MB is not available at a particular hospital, transfer of the patient to a hospital that stocks MB should be considered.
Keywords methemoglobinemia aniline methylene blue cyanosis
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 209
End Page 212
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574260
Web of Science KeyUT 001524768800008
JaLCDOI 10.18926/AMO/68728
FullText URL 79_3_205.pdf
Author Fujita, Yasufumi| Shimizu, Shuji|
Abstract Perigraft seroma, a sterile fluid accumulation around the graft, is a potential complication after thoracic aortic surgery. The optimal treatment strategy for a perigraft seroma with vascular compression after thoracic aortic surgery has been unclear. We describe the case of a 62-year-old Japanese male in whom an asymptomatic perigraft seroma was observed after he had undergone aortic root replacement for annulo-aortic ectasia. The seroma was successfully treated with thoracoscopic drainage and conservative therapy. Less invasive therapy, including conservative therapy, may also be an option for asymptomatic perigraft seromas observed after thoracic aortic surgery.
Keywords perigraft seroma aortic root replacement thoracoscopic drainage conservative therapy
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 205
End Page 208
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574259
Web of Science KeyUT 001524768800007
JaLCDOI 10.18926/AMO/68727
FullText URL 79_3_197.pdf
Author Kondo, Naoki| Kakutani, Rika| Mochizuki, Tomoharu| Wakui, Junichi | Hao, Nariaki| Kinoshita, Eiji| Kawashima, Hiroyuki|
Abstract A 67-year-old woman with rheumatoid arthritis presented with an untriggered hematoma in the right shoulder joint. Radiographic findings showed humeral head collapse and destruction of the glenoid fossa with ectopic calcification. Calcium pyrophosphate deposition (CPPD) in the synovial fluid was observed using a polarizing microscope. Histopathological findings revealed chronic inflammatory cell infiltration and giant cells surrounded by CPPD. The patient was diagnosed with rapid destructive arthropathy (RDA). Endoscopic shoulder joint debridement was performed. Postoperatively, active flexion improved from 40 to 75 degrees. This case highlights that CPPD can cause RDA in the shoulder, detectable with detailed histopathology.
Keywords rheumatoid arthritis calcium pyrophosphate deposition rapid destructive arthropathy case report
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 197
End Page 203
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574258
Web of Science KeyUT 001524768800006
JaLCDOI 10.18926/AMO/68724
FullText URL 79_3_167.pdf
Author Kanaji, Nobuhiro| Nishii, Kazuya| Tsubata, Yukari| Nakao, Mika| Okuno, Takae| Okawa, Sachi| Takata, Kenji| Kodani, Masahiro| Yamasaki, Masahiro| Fujitaka, Kazunori| Kubota, Tetsuya| Inoue, Masaaki| Watanabe, Naoki| Hotta, Katsuyuki| CS-Lung-003 Investigator|
Abstract This prospective observational study investigated the clinical status of patients with advanced non-small cell lung cancer (NSCLC) treated with cytotoxic chemotherapy+an immune checkpoint inhibitor (chemo + IO) as first-line treatment in a real-world setting. The cases of 98 patients treated with chemo + IO were prospectively collected and analyzed for effectiveness and safety. The response rate to chemo + IO was 46.9%, and the disease control rate was 76.5%. The median progression-free survival and overall survival (OS) in the total population were 5.2 and 22.3 months, respectively. The patients positive for PD-L1 (≥ 1%) showed significantly longer OS than the negative group (<1%) (median 26.7 vs. 18.7 months, p=0.04). Pre-existing interstitial lung disease (ILD) was associated with shorter OS than the absence of ILD (median 9.0 vs. 22.6 months, p<0.01). Immunerelated adverse events (irAEs) were observed in 28 patients (28.6%). The most frequent irAE was ILD (n=11); Grade 1 (n=1 patient), G2 (n=5), G3 (n=4), and only a single patient with a G5 irAE. In this CS-Lung-003 study, first-line chemo + IO in a real-world setting showed good effectiveness, comparable to that observed in international clinical trials. In real-world practice, chemo + IO is a promising and steadfast strategy.
Keywords non-small cell lung cancer real-world first-line immune checkpoint inhibitor combined immunotherapy
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 167
End Page 176
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574255
Web of Science KeyUT 001524768800003
JaLCDOI 10.18926/AMO/68723
FullText URL 79_3_157.pdf
Author Hatipoglu, Omer Faruk| Nishinaka, Takashi| Yaykasli, Kursat Oguz| Mori, Shuji| Watanabe, Masahiro| Toyomura, Takao| Nishibori, Masahiro| Hirohata, Satoshi| Takahashi, Hideo| Wake, Hidenori|
Abstract Chondrocytes are responsible for the production of extracellular matrix (ECM) components such as collagen type II alpha-1 (COL2A1) and aggrecan, which are loosely distributed in articular cartilage. Chondrocyte dysfunction has been implicated in the pathogenesis of rheumatic diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). With age, advanced glycation end products (AGEs) accumulate in all tissues and body fluids, including cartilage and synovial fluid, causing and accelerating pathological changes associated with chronic diseases such as OA. Glycolaldehyde-derived AGE (AGE3), which is toxic to a variety of cell types, have a stronger effect on cartilage compared with other AGEs. To understand the long-term effects of AGE3 on cartilage, we stimulated a human chondrosarcoma cell line (OUMS-27), which exhibits a chondrocytic phenotype, with 10 μg/ml AGE3 for 4 weeks. As a result, the expressions of COL2A1 and aggrecan were significantly downregulated in the OUMS-27 cells without inducing cell death, but the expressions of proteases that play an important role in cartilage destruction were not affected. Inhibition of the receptor for advanced glycation end products (RAGE) suppressed the AGE3-induced reduction in cartilage component production, suggesting the involvement of RAGE in the action of AGE3.
Keywords advanced glycation end product aging cartilage collagen aggrecan
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 157
End Page 166
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574254
Web of Science KeyUT 001524768800002
JaLCDOI 10.18926/AMO/68722
FullText URL 79_3_147.pdf
Author Watanabe, Haruki| Matsumoto, Yoshinori| Wada, Jun|
Abstract Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes.
Keywords systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2025-06
Volume volume79
Issue issue3
Publisher Okayama University Medical School
Start Page 147
End Page 155
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2025 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 40574253
Web of Science KeyUT 001524768800001
FullText URL fulltext.pdf
Author Fukushima, Kazuhiko| Tsuji, Kenji| Nakanoh, Hiroyuki| Uchida, Naruhiko| Haraguchi, Soichiro| Kitamura, Shinji| Wada, Jun|
Keywords artificial intelligence case reports peritoneal dialysis text mining
Published Date 2025-03-26
Publication Title Therapeutic Apheresis and Dialysis
Volume volume29
Issue issue3
Publisher Wiley
Start Page 459
End Page 470
ISSN 1744-9979
NCID AA12013945
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40143459
DOI 10.1111/1744-9987.70013
Web of Science KeyUT 001480833800002
Related Url isVersionOf https://doi.org/10.1111/1744-9987.70013
FullText URL fulltext.pdf
Author Nakanoh, Hiroyuki| Tsuji, Kenji| Fukushima, Kazuhiko| Haraguchi, Soichiro| Kitamura, Shinji| Wada, Jun|
Keywords Acute kidney injury Drug-induced nephrotoxicity Kidney organoid Kidney stem cell
Published Date 2025-02-20
Publication Title American Journal of Nephrology
Publisher S. Karger AG
ISSN 0250-8095
NCID AA10424676
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 39978331
DOI 10.1159/000544795
Web of Science KeyUT 001468823100001
Related Url isVersionOf https://doi.org/10.1159/000544795
FullText URL fulltext.pdf
Author Kuriu, Ayano| Ishikawa, Kazuya| Tsuchiya, Kohsuke| Furuta, Kazuyuki| Kaito, Chikara|
Keywords animal infection model Staphylococcus aureus Listeria monocytogenes Pseudomonas aeruginosa antibiotics efficacy virulence genes hemolysin
Published Date 2025-05-01
Publication Title Infection and Immunity
Publisher American Society for Microbiology
ISSN 0019-9567
NCID AA00673732
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Kuriu et al.
File Version publisher
PubMed ID 40310291
DOI 10.1128/iai.00126-25
Web of Science KeyUT 001479415700001
Related Url isVersionOf https://doi.org/10.1128/iai.00126-25
FullText URL fulltext.pdf
Author Watanabe, Yuta| Kunishi, Kotomi| Matsui, Hidenori| Sakata, Nanami| Noutoshi, Yoshiteru| Toyoda, Kazuhiro| Ichinose, Yuki|
Keywords horizontal gene transfer integrative and conjugative elements pathogenicity island Pseudomonas syringae tabtoxin
Published Date 2025-05-12
Publication Title Molecular Plant Pathology
Volume volume26
Issue issue5
Publisher Wiley
Start Page e70087
ISSN 1464-6722
NCID AA11546828
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40356278
DOI 10.1111/mpp.70087
Web of Science KeyUT 001488297600001
Related Url isVersionOf https://doi.org/10.1111/mpp.70087
FullText URL fulltext.pdf
Author Kuang, Canyan| Hirai, Anna| Kamei‑Νagata, Chiaki| Nango, Hiroshi| Ohtani, Masahiro| Omori, Kazuhiro| Takashiba, Shogo|
Keywords AGE experimental periodontitis bone resorption inflammation osteoclasts
Published Date 2025-04-11
Publication Title Biomedical Reports
Volume volume22
Issue issue6
Publisher Spandidos Publications
Start Page 97
ISSN 2049-9434
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders Copyright © 2025 Kuang et al.
File Version publisher
PubMed ID 40297801
DOI 10.3892/br.2025.1975
Web of Science KeyUT 001477956200001
Related Url isVersionOf https://doi.org/10.3892/br.2025.1975
FullText URL fulltext.pdf
Author Hori, Tomoki| Yamamoto, Kazuhiro| Nakagawa, Tomoaki| Nakagawa, Rinako| Okayama, Masami| Sudou, Tamika| Hamasaki, Moe| Yasuda, Mai| Kobayashi, Shinya| Nakamura, Fumihiko| Yagi, Hideo| Kitahiro, Yumi| Ikushima, Shigeki| Yano, Ikuko|
Keywords Rituximab Infusion reaction Bepotastine Diphenhydramine
Note The version of record of this article, first published in International Journal of Hematology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s12185-025-03990-6|
Published Date 2025-04-29
Publication Title International Journal of Hematology
Publisher Springer Science and Business Media LLC
ISSN 0925-5710
NCID AA10797094
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40301270
DOI 10.1007/s12185-025-03990-6
Web of Science KeyUT 001478836900001
Related Url isVersionOf https://doi.org/10.1007/s12185-025-03990-6
FullText URL fulltext.pdf
Author Kondo, Hiroya| Tazawa, Hiroshi| Fujiwara, Tomohiro| Yoshida, Aki| Kure, Miho| Demiya, Koji| Kanaya, Nobuhiko| Hata, Toshiaki| Uotani, Koji| Hasei, Joe| Kunisada, Toshiyuki| Kagawa, Shunsuke| Yoshioka, Yusuke| Ozaki, Toshifumi| Fujiwara, Toshiyoshi|
Keywords Osteosarcoma Lung metastasis Tumor-associated macrophage CCL2 Extracellular vesicle
Note The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-025-04051-x|
Published Date 2025-05-09
Publication Title Cancer Immunology, Immunotherapy
Volume volume74
Issue issue7
Publisher Springer
Start Page 193
ISSN 0340-7004
NCID AA00598499
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025
File Version publisher
PubMed ID 40343498
DOI 10.1007/s00262-025-04051-x
Web of Science KeyUT 001485530100002
Related Url isVersionOf https://doi.org/10.1007/s00262-025-04051-x