感作動物臓器組織の試験管内における過敏症の発現とその電位に就いて 第2編 臓器組織の過敏症ショックに於ける電位変化に及ぼす抗ヒスタミン剤の影響

The author studied the effect of the antihistamine drugs on the rise of the potential in in vitro anaphylactic shock. The liver slice of the guinea-pig sensitized with the horse serum (0.25 cc) was suspended in Tyrode solution, and then the horse serum was poured into this suspension, thus producing anaphylactic shock. The following antihistamine drugs were used; benadrine (aminoether derivative), pyribenzamine (ethylene-diamine derivative) and anergen (pheno-thiazine derivative). The results are summarized as follows: 1) The rise of potential of the sensitized guinea-pig liver by pouring the horse serum was inhibited by addition of antihistamine drugs. 2) In the inhibition of the rise of potential, benadrine of 3.3×10(-3) -3.3×10(-5) mg / cc was more effective than 3.3 (×) 10 (-6) -3.3×10(-7) mg / cc. 3) For the inhibition of the rise of potential in anaphylactic shock, addition of benabrine 30 to 45 minutes before pouring the serum was more effective than 10 to 20 mintes before pouring. 4) For the inhibition of the rise of potentiol in anaphylactic shock, benadrine and pyribenzamine showed nearly the same effect, but anergen seemed to be somewhat less effective than the other two ones.