result 24463 件
| JaLCDOI | 10.18926/AMO/48085 |
|---|---|
| FullText URL | 66_1_77.pdf |
| Author | Zhang, Wei| Tanaka, Masato| Sugimoto, Yoshihisa| Ikuma, Hisanori| Nakanishi, Kazuo| Misawa, Haruo| |
| Abstract | Many authors have reported on iatrogenic vertebral artery (VA) injury, but, to our knowledge, this is the first report of a dominant VA injury with compensatory blood flow from the hypoplastic VA. A 23-year-old woman with juvenile rheumatoid arthritis and atlantoaxial subluxation sustained injury to her dominant VA after occipitocervical fusion using transarticular screws. This did not result in lethal consequences due to compensation from her hypoplastic contralateral VA. Postoperative angiography, however, illustrated occlusion of the dominant left side, while the hypoplastic VA of the right side was enlarged. The patient experienced vertigo and loss of consciousness several times during rehabilitation. At the 4-year follow-up exam, bony fusion was observed, with no neurological deficits or correction loss. She had had no episodes of unconsciousness and no recurrence of any symptoms over the previous 3 years. |
| Keywords | atlantoaxial subluxation vertebral artery injury transarticular screw rheumatoid arthritis |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 77 |
| End Page | 81 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358143 |
| Web of Science KeyUT | 000300800700011 |
| JaLCDOI | 10.18926/AMO/48084 |
|---|---|
| FullText URL | 66_1_73.pdf |
| Author | Yoshida, Yukihiro| Kojima, Toshio| Taniguchi, Masashi| Osaka, Shunzo| Tokuhashi, Yasuaki| |
| Abstract | We report a 38-year old man with a giant-cell tumor in a rare site, the patella. Primary patellar neoplasms are highly unusual. According to a survey by the Bone and Soft Tissue Tumor Committee of the Japanese Orthopaedic Association, of more than 2,126 giant-cell tumors of bone reported since 1972, only 22 were primary patellar neoplasms. We present a case of this rare entity along with its clinical and radiographic features. The first clinical symptom was anterior knee pain. Though anterior knee pain has numerous and varied causes, it is necessary to consider patellar bone tumors in the differential diagnosis. |
| Keywords | giant-cell tumor patella knee pain |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 73 |
| End Page | 76 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358142 |
| Web of Science KeyUT | 000300800700010 |
| JaLCDOI | 10.18926/AMO/48083 |
|---|---|
| FullText URL | 66_1_67.pdf |
| Author | Sasaki, Shinsuke| Murakami, Naoki| Matsumura, Yuko| Ichimura, Mika| Mori, Masaharu| |
| Abstract | This study investigated the appropriate tourniquet pressure (TP) and duration of tourniquet application for venipuncture by calculating the venous cross-section (VCS) area on ultrasonography. Twenty healthy volunteers without cardiovascular risk factors were enrolled in this study. A target vein (either a cephalic or median cubital vein) was selected on ultrasonography. The pneumatic tourniquet was inflated using a rapid cuff inflator system at setting pressure for 120sec. TP strength was varied from 20mmHg to 100mmHg, in 20mmHg increments. The order of TP was randomized. Compari-sons among more than 3 groups were performed by one-way repeated-measures ANOVA and the Bonferroni method. The VCS area increased rapidly until 10sec after tourniquet inflation. The VCS area then increased gradually until 30sec after tourniquet inflation. After that, the VCS area did not increase remarkably. The VCS area increased with TP strength up to 80mmHg, but the VCS area at TP 100mmHg decreased to less than that at TP 40mmHg. Based on these results, we recommend a tourniquet pressure of 60mmHg, and duration of tourniquet application is 30 to 60sec for venipuncture. |
| Keywords | venipuncture tourniquet pressure tourniquet duration venous cross-section area ultrasonography |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 67 |
| End Page | 71 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358141 |
| Web of Science KeyUT | 000300800700009 |
| JaLCDOI | 10.18926/AMO/48082 |
|---|---|
| FullText URL | 66_1_61.pdf |
| Author | Maruyama, Hidehiko| Kitajima, Hiroyuki| Yonemoto, Naohiro| Fujimura, Masanori| |
| Abstract | Percutaneously inserted central catheters (PICCs) are often used in neonatal medicine. Venous thrombosis (VT) is one of the complications associated with PICC use. According to some reports, fresh frozen plasma (FFP) may be a risk factor for VT. The purpose of this study was to determine whether FFP use is associated with VT in extremely low birth weight infants (ELBWIs). We performed a matched case-control study on risk factors for VT in ELBWIs born over a period of 5 years in the neonatal intensive care unit of a tertiary hospital. Controls were infants from the unit matched for gestational age and birth weight. We performed univariate analyses and created receiver operating characteristic (ROC) curves for the cut-off values of continuous parameters such as FFP. We also conducted multivariate conditional logistic regression analysis and calculated adjusted odds ratios and their 95% confidence intervals. Thirteen VT cases and 34 matched controls were examined. Using an ROC curve, FFP by day 5＞50mL/kg was selected as the cut-off value. In multivariate conditional logistic regression analysis, FFP by day 5＞50mL/kg exhibited an adjusted odds ratio of 5.88 (95% confidence interval:1.12-41.81, p＝0.036). FFP by day 5＞50mL/kg may be a risk factor for VT in ELBWIs. |
| Keywords | extremely low birth weight infants fresh frozen plasma venous thrombosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 61 |
| End Page | 66 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358140 |
| Web of Science KeyUT | 000300800700008 |
| JaLCDOI | 10.18926/AMO/48081 |
|---|---|
| FullText URL | 66_1_53.pdf |
| Author | Nakamura, Keiichiro| Hongo, Atsushi| Kodama, Junichi| Hiramatsu, Yuji| |
| Abstract | The purpose of this study was to evaluate prognostic factors for epithelial ovarian cancer. We found that the pretreatment values of maximum standardized uptake (SUVmax) of the primary tumor by positron emission tomography/computed tomography (PET/CT), tumor marker CA125 and C-reactive protein (CRP) were correlated with clinical characteristics and prognosis for such patients. The clinical parameters and prognoses and their correlations with SUVmax of primary tumor, CA125 and CRP were examined for 51 patients with primary ovarian cancer. The SUVmax of the primary tumor had a statistically significant association with stage (p＝0.010) and histology (p＝0.001). CA125 was significant associated with stage (p＝0.011), histology (p＝0.005) and lymph node metastasis (p＝0.025). CRP was also significantly associated with stage (p＝0.049). Disease-free survival rates of patients exhibiting a high SUVmax, CA125 and CRP were significantly lower than those exhibiting a low SUVmax, CA125 and CRP levels (p＝0.008, 0.034, and 0.037, respectively). Furthermore, overall survival rates of patients exhibiting a high SUVmax were significantly lower than those exhibiting a low SUVmax (p＝0.049).The high SUVmax of primary tumor is an important factor for identifying ovarian cancer patients with a predictor for poor prognosis. |
| Keywords | ovarian cancer SUVmax of primary tumor CA125 C-reactive protein predictor for poor prognosis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 53 |
| End Page | 60 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358139 |
| Web of Science KeyUT | 000300800700007 |
| JaLCDOI | 10.18926/AMO/48080 |
|---|---|
| FullText URL | 66_1_41.pdf |
| Author | Ohtsu, Tadahiro| Kaneita, Yoshitaka| Ishimura, Yohei| Aritake, Sayaka| Mishima, Kazuo| Uchiyama, Makoto| Akashiba, Tsuneto| Uchimura, Naohisa| Nakaji, Shigeyuki| Munezawa, Takeshi| Shimada, Naoki| Kokaze, Akatsuki| Ohida, Takashi| |
| Abstract | Little research has been done on the association between relaxation and health. In the present study, by conducting a nationwide cross-sectional survey, we aimed to obtain scientific data on the preferable forms of relaxation for health promotion, and to clarify the associations between specific recreational activities and self-perceived mental and physical health. We selected 4,000 households by stratified random sampling from across Japan in November 2009 and used the interview method to collect data (number of subjects:2,206). The questionnaire contained items on sleep, recreation status, recreational activities, and self-perceived mental and physical health status. We obtained responses from 1,224 adults (response rate:55.5%). Insufficient rest from sleep, short sleep duration (＜6h/day), ineffective use of free time, and less free time used for activities other than rest showed independent positive associations with poor mental and physical health. The results of the logistic regression analyses showed significantly low adjusted odds ratios with regard to the status of poor mental and physical health for outings/walking among men (0.33 [95% confidence interval;0.16-0.68] and 0.49 [0.26-0.90], respectively), and for community activities among women (0.19 [0.04-0.79] and 0.27 [0.09-0.77], respectively). Relaxation for the promotion of health should include both passive relaxation (rest) and active relaxation (recreation). In addition, ensuring sufficient sleep duration is important for passive relaxation, and engaging in outings/walking for men and community activities for women are important for active relaxation. |
| Keywords | passive relaxation active relaxation recreational activity self-perceived health |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 41 |
| End Page | 51 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358138 |
| Web of Science KeyUT | 000300800700006 |
| JaLCDOI | 10.18926/AMO/48079 |
|---|---|
| FullText URL | 66_1_31.pdf |
| Author | Utsumi, Hiroya| Terashi, Hiroo| Ishimura, Yohei| Takazawa, Tomoko| Hayashi, Akito| Mochizuki, Hideki| Okuma, Yasuyuki| Orimo, Satoshi| Takahashi, Kazushi| Yoneyama, Mitsuru| Mitoma, Hiroshi| |
| Abstract | To quantify gait bradykinesia during daily activity in patients with Parkinson's disease (PD), we measured movement-induced accelerations over more than 24h in 50 patients with PD and 17 age-matched normal controls, using a new device, the portable gait rhythmogram. Acceleration values induced by various movements, averaged each 10 min, exhibited a gamma distribution. The mean value of the distribution curve was used as an index of the "amount of overall movement per 24h". Characteristic changes were observed in both the gait cycle and gait acceleration. During hypokinesia, the gait cycle became either faster or slower. A number of patients with marked akinesia/bradykinesia showed a reduced and narrow range of gait acceleration, i.e., a range of floor reaction forces. The results suggest that assessment of the combination of changes in gait cycle and gait acceleration can quantitatively define the severity of gait bradykinesia. |
| Keywords | Parkinson's disease gait disorders portable gait rhythmogram |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 31 |
| End Page | 40 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358137 |
| Web of Science KeyUT | 000300800700005 |
| JaLCDOI | 10.18926/AMO/48078 |
|---|---|
| FullText URL | 66_1_23.pdf |
| Author | Watanabe, Toyohiko| Inoue, Miyabi| Ishii, Ayano| Yamato, Toyoko| Yamamoto, Masumi| Sasaki, Katsumi| Kobayashi, Yasuyuki| Araki, Motoo| Uehara, Shinya| Saika, Takashi| Kumon, Hiromi| |
| Abstract | Polypropylene mesh implants for the correction of pelvic organ prolapse (POP) are now available in Japan. We developed an innovative approach for correcting POP by placing polypropylene mesh transvaginally with laparoscopic assistance. From June 2007 through March 2010, sixteen consecutive patients with symptomatic stage 2 or 3 pelvic organ prolapse underwent the laparoscopic-assisted tension-free vaginal mesh procedure at Okayama University Hospital. All patients were evaluated before and at 1, 3, 6, and 12 months after surgery. Female sexual function was also evaluated with the Female Sexual Function Index (FSFI). The procedure was performed successfully without significant complications. Fifteen of 16 patients were considered anatomically cured (93.8%) at 12 months postoperatively. One patient with a recurrent stage 3 vaginal vault prolapse required sacral colpopexy six months postoperatively. Total FSFI scores improved significantly from 10.3±1.3 at baseline to 18.0±1.2 at 12 months after surgery. The laparoscopic-assisted trans-vaginal mesh is a safe, effective, and simple procedure for POP repairs. The procedure not only restores anatomic relationships but also improves sexual function. |
| Keywords | tension-free vaginal mesh pelvic organ prolapse laparoscopic female urology sexual function |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 23 |
| End Page | 29 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358136 |
| Web of Science KeyUT | 000300800700004 |
| JaLCDOI | 10.18926/AMO/48077 |
|---|---|
| FullText URL | 66_1_17.pdf |
| Author | Hayashida, Keiichi| Takeda, Yoshihiro| Katsuda, Toshizo| Yamamoto, Kenyu| Suesada, Yasuhide| Shibata, Moeko| Azuma, Masami| |
| Abstract | Proximal femoral bone mineral density (BMD) can be measured by dual energy X-ray absorptiometry method in the neck, trochanter, intertrochanter, total and Ward's triangle area. Ward's triangle area of the proximal femur is a smaller area to measure than the others, and the position varies, depending on the status of inner rotation of the target leg. In this study, the measurements of the proximal femoral BMD in women were carried out on the neck, trochanter, intertrochanter, total and Ward's triangle area with the, subjects' legs turned 15 degrees toward the inside. The Ward's BMD were measured using Ward's cognitive method, in which the measured BMD were compared among age groups of 50-59, 60-69, 70-79 and 80-89 to determine whether this process could reveal decreased femoral BMD in elderly women. The correlation between BMD and age was tested using the Pearson correlation coefficient. In all measured parts, the BMD of women age 50-59 were significantly higher than those of women age 80-89. The correlations between BMD and age were negative in all measured parts, and the most negative correlation was between age and Ward's BMD. The study using Ward's cognitive method showed an inverse correlation between Ward's BMD and age in women. |
| Keywords | proximal femoral BMD dual energy X-ray absorptiometry Wardʼs BMD Wardʼs cognitive method |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 17 |
| End Page | 21 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358135 |
| Web of Science KeyUT | 000300800700003 |
| JaLCDOI | 10.18926/AMO/48076 |
|---|---|
| FullText URL | 66_1_7.pdf |
| Author | Kawauchi, Keiichiro| Watanabe, Masami| Kaku, Haruki| Huang, Peng| Sasaki, Kasumi| Sakaguchi, Masakiyo| Ochiai, Kazuhiko| Huh, Nam-ho| Nasu, Yasutomo| Kumon, Hiromi| |
| Abstract | The preclinical safety and therapeutic efficacy of adenoviral vectors that express the REIC/Dkk-3 tumor suppressor gene (Ad-REIC) was examined for use in prostate cancer gene therapy. The Ad-human (h) and mouse (m) REIC were previously demonstrated to induce strong anti-cancer effects in vitro and in vivo, and we herein report the results of two in vivo studies. First, intra-tumor Ad-hREIC administration was examined for toxicity and therapeutic effects in a subcutaneous tumor model using the PC3 prostate cancer cell line. Second, intra-prostatic Ad-mREIC administration was tested for toxicity in normal mice. The whole-body and spleen weights, hematological and serum chemistry parameters, and histological evaluation of tissues from throughout the body were analyzed. Both experiments indicated that there was no significant difference in the examined parameters between the Ad-REIC-treated group and the control (PBS- or Ad-LacZ-treated) group. In the in vitro analysis using PC3 cells, a significant apoptotic effect was observed after Ad-hREIC treatment. Confirming this observation, the robust anti-tumor efficacy of Ad-hREIC was demonstrated in the in vivo subcutaneous prostate cancer model. Based on the results of these preclinical experiments, we consider the adenovirus-mediated REIC/Dkk-3 in situ gene therapy to be safe and useful for the clinical treatment of prostate cancer. |
| Keywords | REIC Dickkopf-3 gene therapy prostate cancer preclinical study |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 7 |
| End Page | 16 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358134 |
| Web of Science KeyUT | 000300800700002 |
| JaLCDOI | 10.18926/AMO/48075 |
|---|---|
| FullText URL | 66_1_1.pdf |
| Author | Udono, Heiichiro| |
| Abstract | Dendritic cells (DCs) take up soluble- or cell-associated antigens and digest them, delivering fragments to the MHC class I pathway to display antigenic peptides to CD8＋ T cells, a process known as cross-presentation. The pathway requires that, in order to be degraded by proteosomes, the extracellular antigens must have access to the cytosol across the endosomal membranes. Although the cross-presentation phenomena was first identified in the 1970s, the molecular mechanism responsible for the translocation is still not fully understood. In this context, we have recently found that cytosolic heat shock protein (HSP)90 translocates internalized antigen to the cytosol in DCs. Our results revealed the important role that cytosolic HSP90 plays in cross-presentation by pulling out endosomal antigen to the cytosol. |
| Keywords | heat shock protein 90 dendritic cells cross-presentation proteasome cytotoxic T cell immunity |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-02 |
| Volume | volume66 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22358133 |
| Web of Science KeyUT | 000300800700001 |
| Author | 岡山医学会| |
|---|---|
| Published Date | 1918-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume30 |
| Issue | issue345 |
| Content Type | Others |
| Author | 岡山医学会| |
|---|---|
| Published Date | 1918-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume30 |
| Issue | issue345 |
| Content Type | Others |
| Author | 横川 定| 末盛 進| |
|---|---|
| Published Date | 1918-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume30 |
| Issue | issue345 |
| Content Type | Journal Article |
| Author | 吉田 千束| |
|---|---|
| Published Date | 1918-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume30 |
| Issue | issue345 |
| Content Type | Journal Article |
| Author | 林 昇| 富岡 敏哉| |
|---|---|
| Published Date | 1918-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume30 |
| Issue | issue345 |
| Content Type | Journal Article |
| Author | 渡邊 善朝| |
|---|---|
| Published Date | 1918-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume30 |
| Issue | issue345 |
| Content Type | Journal Article |
| Author | 上坂 熊勝| 關 正次| |
|---|---|
| Published Date | 1918-10-31 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume30 |
| Issue | issue345 |
| Content Type | Journal Article |
| Author | 岡山医学会| |
|---|---|
| Published Date | 1918-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume30 |
| Issue | issue344 |
| Content Type | Others |
| Author | 岡山医学会| |
|---|---|
| Published Date | 1918-09-30 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume30 |
| Issue | issue344 |
| Content Type | Others |
