result 1530 件
| Title Alternative | The List of Published by Members of the Faculty From January to December 2017 |
|---|---|
| FullText URL | srfa_107_025_039.pdf |
| Author | Faculty of Agriculture, Okayama University| |
| Publication Title | Scientific Reports of the Faculty of Agriculture, Okayama University |
| Published Date | 2018-02-01 |
| Volume | volume107 |
| Start Page | 25 |
| End Page | 39 |
| ISSN | 2186-7755 |
| language | Japanese |
| File Version | publisher |
| Title Alternative | Alzheimer’s disease : Relationship between the Alzheimer’s disease and human microbiome |
|---|---|
| FullText URL | srfa_107_005_010.pdf |
| Author | Fujii, Yusuke| Morita, Hidetoshi| |
| Abstract | Alzheimer’s disease (AD) is a progressive, neurodegenerative disease characterized by memory and language disorder. The accumulation of senile plaques called β-amyloid and neurofibrillary tangles involving protein tau in the brains of AD patients have been considered as two hallmarks of AD. In AD, it is reported that accumulation of β-amyloid may be observed 25 years before onset, supporting early diagnosis and treatment by brain image analysis, because several techniques have recently been developed to detect β-amyloid and tau protein in brains of persons diagnosed with AD. AD patients are usually suffering from other diseases such as diabetes or periodontal disease, and there is accumulating data to show that these diseases associate with the human microbiome, such as gut and oral microbiota. In this report, the relation ship between AD and the human microbiome is reviewed. |
| Publication Title | Scientific Reports of the Faculty of Agriculture, Okayama University |
| Published Date | 2018-02-01 |
| Volume | volume107 |
| Start Page | 5 |
| End Page | 10 |
| ISSN | 2186-7755 |
| language | Japanese |
| File Version | publisher |
| FullText URL | GGI_16_4_440.pdf fig.pdf |
|---|---|
| Author | Tokuchi, Ryo| Hishikawa, Nozomi| Matsuzono, Kosuke| Takao, Yoshiki| Wakutani, Yosuke| Sato, Kota| Kono, Syoichiro| Ohta, Yasuyuki| Deguchi, Kentaro| Yamashita, Toru| Abe, Koji| |
| Keywords | Alzheimer's disease affective function cognitive function combination therapy galantamine |
| Note | This is an Accepted Manuscript of an article published by Wiley| |
| Published Date | 2016-04 |
| Publication Title | Geriatrics & Gerontology International |
| Volume | volume16 |
| Issue | issue4 |
| Publisher | Japan Geriatrics Society |
| Start Page | 440 |
| End Page | 445 |
| ISSN | 1444-1586 |
| NCID | AA1155729X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 25952367 |
| DOI | 10.1111/ggi.12488 |
| Web of Science KeyUT | 000373611800005 |
| Related Url | isVersionOf https://doi.org/10.1111/ggi.12488 |
| FullText URL | CGI_17_11_1843.pdf fig.pdf |
|---|---|
| Author | Ohta, Yasuyuki| Darwish, Mohamed| Hishikawa, Nozomi| Yamashita, Toru| Sato, Kota| Takemoto, Mami| Abe, Koji| |
| Keywords | Alzheimer's disease donepezil drug switch galantamine rivastigmine |
| Note | This is an Accepted Manuscript of an article published by Wiley| |
| Published Date | 2017-11 |
| Publication Title | Geriatrics & Gerontology International |
| Volume | volume17 |
| Issue | issue11 |
| Publisher | Japan Geriatrics Society |
| Start Page | 1843 |
| End Page | 1848 |
| ISSN | 1444-1586 |
| NCID | AA1155729X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | author |
| PubMed ID | 28060449 |
| DOI | 10.1111/ggi.12971 |
| Web of Science KeyUT | 000416330000009 |
| Related Url | isVersionOf https://doi.org/10.1111/ggi.12971 |
| Title Alternative | The 2016 Incentive Award of the Okayama Medical Association in Neuroscience (2016 Niimi Prize) |
|---|---|
| FullText URL | 129_167.pdf |
| Author | Ikeda, Chikako| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-12-01 |
| Volume | volume129 |
| Issue | issue3 |
| Start Page | 167 |
| End Page | 169 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.129.167 references https://doi.org/10.1111/bpa.12319 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.167 |
| NAID | 40021393828 |
| JaLCDOI | 10.18926/AMO/55591 |
|---|---|
| FullText URL | 71_6_531.pdf |
| Author | Ooi, Mayu| Yanamoto, Fujio| Sato, Hitoaki| Takao, Yumiko| Okada, Masako| Egi, Moritoki| Mizobuchi, Satoshi| |
| Abstract | Although spinal cord stimulation (SCS) is a useful treatment for chronic intractable pain, the optimal method of stimulation has not yet been established. In this prospective, crossover study, we compared the efficacy of using a constant current (CC) system with that of a constant voltage (CV) system for temporal SCS. Twenty patients were enrolled and divided into two groups. For 10 patients, a CV system was applied on Days 1-5, followed by the use of a CC system on Days 6-10. For the other 10 patients, a CC system was applied for the first five days, followed by a CV system for the subsequent five days. We evaluated the alteration of pain intensity using a visual analogue scale (VAS), the area of stimulation, the stability of effect, and patient satisfaction regarding treatment. The pain scores decreased significantly after the start of the SCS. There was no significant difference in the change in VAS between the two systems. The stimulation method used for temporal SCS did not affect the reduction of pain intensity. Patients felt a wider stimulation area by the CC system compared to the CV system. |
| Keywords | spinal cord stimulation constant current system constant voltage system chronic intractable pain pain score |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-12 |
| Volume | volume71 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 531 |
| End Page | 537 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29276227 |
| JaLCDOI | 10.18926/AMO/55582 |
|---|---|
| FullText URL | 71_6_459.pdf |
| Author | Sakaguchi, Masakiyo| Kinoshita, Rie| Endy Widya Putranto| I Made Winarsa Ruma| I Wayan Sumardika| Youyi, Chen| Tomonobu, Naoko| Yamamoto, Ken-ichi| Murata, Hitoshi| |
| Abstract | The receptor for advanced glycation end products (RAGE) is involved in inflammatory pathogenesis. It functions as a receptor to multiple ligands such as AGEs, HMGB1 and S100 proteins, activating multiple intracellular signaling pathways with each ligand binding. The molecular events by which ligand-activated RAGE controls diverse signaling are not well understood, but some progress was made recently. Accumulating evidence revealed that RAGE has multiple binding partners within the cytoplasm and on the plasma membrane. It was first pointed out in 2008 that RAGE’s cytoplasmic tail is able to recruit Diaphanous-1 (Dia-1), resulting in the acquisition of increased cellular motility through Rac1/Cdc42 activation. We also observed that within the cytosol, RAGE’s cytoplasmic tail behaves similarly to a Toll-like receptor (TLR4)-TIR domain, interacting with TIRAP and MyD88 adaptor molecules that in turn activate multiple downstream signals. Subsequent studies demonstrated the presence of an alternative adaptor molecule, DAP10, on the plasma membrane. The coupling of RAGE with DAP10 is critical for enhancing the RAGE-mediated survival signal. Interestingly, RAGE interaction on the membrane was not restricted to DAP10 alone. The chemotactic G-protein-coupled receptors (GPCRs) formyl peptide receptors1 and 2 (FPR1 and FPR2) also interacted with RAGE on the plasma membrane. Binding interaction between leukotriene B4 receptor 1 (BLT1) and RAGE was also demonstrated. All of the interactions affected the RAGE signal polarity. These findings indicate that functional interactions between RAGE and various molecules within the cytoplasmic area or on the membrane area coordinately regulate multiple ligand-mediated RAGE responses, leading to typical cellular phenotypes in several pathological settings. Here we review RAGE’s signaling diversity, to contribute to the understanding of the elaborate functions of RAGE in physiological and pathological contexts. |
| Keywords | receptor for advanced glycation end products RAGE adaptor protein signal transduction inflammatory pathogenesis |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-12 |
| Volume | volume71 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 459 |
| End Page | 465 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 29276218 |
| JaLCDOI | 10.18926/okadai-bun-kiyou/55578 |
|---|---|
| FullText URL | jfl_068_085_100.pdf |
| Author | Renoud, Loïc| |
| Publication Title | Journal of the Faculty of Letters Okayama University |
| Published Date | 2017-12-22 |
| Volume | volume68 |
| Start Page | 85 |
| End Page | 100 |
| ISSN | 0285-4864 |
| language | English |
| File Version | publisher |
| NAID | 120006370706 |
| FullText URL | K0005614_abstract_review.pdf K0005614_fulltext.pdf |
|---|---|
| Author | Neha, Nair| |
| Published Date | 2017-09-29 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5614号 |
| Granted Date | 2017-09-29 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005612_abstract_review.pdf K0005612_summary.pdf K0005612_fulltext.pdf |
|---|---|
| Author | Ren, Yanna| |
| Published Date | 2017-09-29 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5612号 |
| Granted Date | 2017-09-29 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005611_abstract_review.pdf K0005611_summary.pdf K0005611_fulltext.pdf |
|---|---|
| Author | MOHD USAIRY SYAFIQ BIN SAMAIN| |
| Published Date | 2017-09-29 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5611号 |
| Granted Date | 2017-09-29 |
| Thesis Type | Doctor of Philosophy in Engineering |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005606_abstract_review.pdf K0005606_fulltext.pdf |
|---|---|
| Author | Pretam Kumar Das| |
| Published Date | 2017-09-29 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5606号 |
| Granted Date | 2017-09-29 |
| Thesis Type | Doctor of Philosophy in Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005604_abstract_review.pdf K0005604_fulltext.pdf |
|---|---|
| Author | Moriyama, Satomi| |
| Published Date | 2017-09-29 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5604号 |
| Granted Date | 2017-09-29 |
| Thesis Type | Doctor of Philosophy in Pharmaceutical Sciences |
| Grantor | 岡山大学 |
| language | Japanese |
| FullText URL | K0005601_abstract_review.pdf K0005601_summary.pdf K0005601_fulltext.pdf K0005601_other.pdf |
|---|---|
| Author | Wang, Dengli| |
| Published Date | 2017-09-29 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5601号 |
| Granted Date | 2017-09-29 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005594_abstract_review.pdf K0005594_summary.pdf K0005594_fulltext.pdf |
|---|---|
| Author | Fu, Li| |
| Published Date | 2017-09-29 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5594号 |
| Granted Date | 2017-09-29 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005593_abstract_review.pdf K0005593_summary.pdf K0005593_fulltext.pdf |
|---|---|
| Author | Kumano, Kenjiro| |
| Published Date | 2017-09-29 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5593号 |
| Granted Date | 2017-09-29 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| FullText URL | K0005584_abstract_review.pdf K0005584_summary.pdf K0005584_fulltext.pdf |
|---|---|
| Author | Omichi, Ryotaro| |
| Published Date | 2017-09-29 |
| Content Type | Thesis or Dissertation |
| Grant Number | 甲第5584号 |
| Granted Date | 2017-09-29 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | English |
| JaLCDOI | 10.18926/bgeou/55482 |
|---|---|
| Title Alternative | A Fundamental Study of Relation between Observation and Drawing (Part4) : Consideration of Relationship between “View Independent Approach” and Drawing Expression |
| FullText URL | bgeou_166_089_097.pdf |
| Author | Kiyota, Tetsuo| |
| Abstract | 本稿は，「観察と描画表現との関係についての基礎研究」の継続研究である。本研究は，学校教育での図画工作科，美術科での児童・生徒の活動のねらい等を明確にするために，観察と描画表現との関係について考察するものである。 本稿では，物体認知において，脳内で二つの視点不変性，視点非依存アプローチと視点依存アプローチが，それぞれ絵画表現にどのように関係し，セザンヌやキュビズム，子どもたちの表現としてどのような形で表出しているかを考察し，今後の研究の方向性を纏めたものである。 |
| Keywords | 観察 描画表現 視認知 セザンヌ キュビスム |
| Publication Title | Bulletin of Graduate School of Education, Okayama University |
| Published Date | 2017-11-28 |
| Volume | volume166 |
| Start Page | 89 |
| End Page | 97 |
| ISSN | 1883-2423 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/55290 http://ousar.lib.okayama-u.ac.jp/54840 http://ousar.lib.okayama-u.ac.jp/54494 |
| language | Japanese |
| File Version | publisher |
| NAID | 120006368131 |
| FullText URL | NatCommun_12138.pdf |
|---|---|
| Author | Huang, Xin-Yuan| Deng, Fenglin| Yamaji, Naoki| Pinson, Shannon R.M.| Fujii-Kashino, Miho| Danku, John| Douglas, Alex| Guerinot, Mary Lou| Salt, David E.| Ma, Jian Feng| |
| Keywords | Genetic variation Natural variation in plants Quantitative trait Rice |
| Note | This is an article published by Nature Publishing Group| |
| Published Date | 2016-07 |
| Publication Title | Nature Communications |
| Volume | volume7 |
| Publisher | Nature Publishing Group |
| Start Page | 12138 |
| ISSN | 2041-1723 |
| NCID | AA12645905 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 27387148 |
| DOI | 10.1038/ncomms12138 |
| Web of Science KeyUT | 000380305000001 |
| Related Url | https://doi.org/10.1038/ncomms12138 |
| FullText URL | NatCommun_12501.pdf |
|---|---|
| Author | Ohtsuki, Takashi| Kanzaki, Shigeto| Nishimura, Sae| Kunihiro, Yoshio| Sisido, Masahiko| Watanabe, Kazunori| |
| Keywords | Molecular engineering Optogenetics |
| Note | This is an article published by Nature Publishing Group| |
| Published Date | 2016-08 |
| Publication Title | Nature Communications |
| Volume | volume7 |
| Start Page | 12501 |
| ISSN | 2041-1723 |
| NCID | AA12645905 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja |
| File Version | publisher |
| PubMed ID | 27530762 |
| DOI | 10.1038/ncomms12501 |
| Web of Science KeyUT | 000381771700001 |
| Related Url | https://doi.org/10.1038/ncomms12501 |
