start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=1 article-no= start-page=1 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Relationships between tilt angles of rectus muscles and positions of rectus muscle pulleys in patients with sagging eye syndrome en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose To examine the relationship between the rectus muscle (RM) angle and RM pulley displacement in patients with sagging eye syndrome (SES) without myopia.
Study design Retrospective cross-sectional case series.
Methods High-resolution quasi-coronal magnetic resonance imaging (MRI) data from 20 orbits of ten Japanese patients with SES but without high myopia were analyzed. The patients had no abduction deficiency. The RM angles were measured between the major axes of the horizontal and vertical RMs relative to the vertical and horizontal planes, respectively. The positions of the RM pulleys relative to the center of the globe were analyzed as previously described.
Results The mean age of the patients was 75.8 ± 4.5 years (standard deviation). The average axial length was 23.6 ± 0.6 mm. The lateral rectus (LR) muscle angle (22 ± 6°) had moderate negative correlations with the inferior displacement of the inferior rectus (IR), superior rectus (SR), and LR pulleys (r =? 0.63,? 0.45, and? 0.45, respectively); however, no change was observed in the medial rectus (MR) pulley (r =? 0.41). No correlations were found between the angles of the SR (4 ± 8°), IR (? 13 ± 8°), and MR (? 1 ± 6°) muscles and the positions of the RM pulleys.
Conclusion Given the correlation between increased LR muscle angle and inferior displacement of adjacent RM pulleys in SES, the LR muscle angle may serve as a diagnostic clue, even when inferior displacement is not identifiable on MRI. Further confirmation in larger studies is warranted. en-copyright= kn-copyright= en-aut-name=KonoReika en-aut-sei=Kono en-aut-mei=Reika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HamasakiIchiro en-aut-sei=Hamasaki en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KishimotoFumiko en-aut-sei=Kishimoto en-aut-mei=Fumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShibataKiyo en-aut-sei=Shibata en-aut-mei=Kiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MorisawaShin en-aut-sei=Morisawa en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MorizaneYuki en-aut-sei=Morizane en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Division of Ophthalmology, Ibara City Hospital, Ibara City kn-affil= affil-num=4 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=Orbital pulley kn-keyword=Orbital pulley en-keyword=Sagging eye syndrome kn-keyword=Sagging eye syndrome en-keyword=Distance esotropia kn-keyword=Distance esotropia en-keyword=Cyclovertical strabismus kn-keyword=Cyclovertical strabismus en-keyword=Aging kn-keyword=Aging END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue= article-no= start-page=1439705 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241211 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=HOMA-beta independently predicts survival in patients with advanced cancer on treatment with immune checkpoint inhibitors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Although immune checkpoint inhibitors (ICIs) are effective cancer drugs, ICI-induced diabetes is a rare but a life-threatening adverse event for patients. The deleterious action of ICI on pancreatic beta-cell function is a concern. However, the influence of ICI on insulin synthesis and secretion in patients with cancer without diabetes remains unknown.
Methods: This study included 87 patients diagnosed with advanced cancer. Glucose metabolism markers (HbA1c, HOMA-IR) and indicators of insulin secretory capacity (HOMA-beta, C-peptide) were prospectively evaluated in patients with ICI-treated cancers to determine their association with cancer prognosis.
Results: Patients with overall survival (OS) >= 7 months had substantially higher HOMA-beta levels at baseline (p=0.008) and 1 month after ICI administration (p=0.006) compared to those with OS <7 months. The median OS was significantly longer in patients with HOMA-beta >= 64.24 (13 months, 95%CI: 5.849-20.151, 37 events) than in those with HOMA-beta < 64.24 (5 months, 95%CI: 3.280-6.720, 50 events) (p=0.013). Further, the median progression-free survival (PFS) was significantly longer in patients with HOMA-beta >= 66.43 (4 months, 95%CI: 3.073-4.927, 33 events) than in those with HOMA-beta < 66.43 (2 months, 95%CI: 1.410-2.590, 54 events) (p=0.025). Additionally, multivariable logistic regression analysis revealed that a HOMA-beta value >= 64.24 independently predicted longer OS in ICI-treated patients.
Conclusions: Pre-ICI HOMA-beta level is linked to longer OS in ICI-treated patients. This connection is significant and shows that insulin secretory capacity may predict ICI efficacy. en-copyright= kn-copyright= en-aut-name=WatanabeMayu en-aut-sei=Watanabe en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EguchiJun en-aut-sei=Eguchi en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakamotoAtsushi en-aut-sei=Takamoto en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KanzakiHiromitsu en-aut-sei=Kanzaki en-aut-mei=Hiromitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NodaYohei en-aut-sei=Noda en-aut-mei=Yohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KagawaSyunsuke en-aut-sei=Kagawa en-aut-mei=Syunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Urology, Fukuyama City Hospital kn-affil= affil-num=4 en-affil=Department of Internal Medicine, Tsuyama Chuo Hospital kn-affil= affil-num=5 en-affil=Department of Urology, Fukuyama City Hospital kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=anti-PD1 immune checkpoint inhibitors kn-keyword=anti-PD1 immune checkpoint inhibitors en-keyword= insulin secretory capacity kn-keyword= insulin secretory capacity en-keyword= cancer prognosis kn-keyword= cancer prognosis en-keyword= insulin secretion kn-keyword= insulin secretion en-keyword= glucose metabolism markers kn-keyword= glucose metabolism markers END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=142592 end-page=142605 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20241001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=MUSIC Spectrum Based Interference Detection, Localization, and Interference Arrival Prediction for mmWave IRS-MIMO System en-subtitle= kn-subtitle= en-abstract= kn-abstract=For a millimeter wave (mmWave) intelligent re-configurable surface (IRS)-MIMO system, if it can correctly detect the interference occurrence and their locations, the patterns of interference signal can be collected and learned using machine learning for the prediction of interference arrival. With the information of interference location and activity pattern, the capacity of the system can be largely improved using many techniques such as beamforming, interference cancellation, and transmission scheduling. This paper aims to detect interference occurrence using a low-complexity MUSIC (MUSIC: multiple signal classification) spectrum-based method, and then localize their sources for mmWave IRS-MIMO system. The MUSIC spectrum of wireless system can be regarded as somehow the 'signature' related to the signals transmitted from different users or interference. We utilize such property to detect the occurrence of interference, and then localize their sources in a low-complexity way. Finally, the pattern of interference occurrence can be learned to predict the interference arrival from the collected data. This paper also proposed an efficient probabilistic neural network (PNN)-based predictor for the interference arrival prediction and showed its prediction accuracy. From simulated results, our proposed method can achieve the correct results with the accuracy near to 100% when the fingerprint samples is over 10. In addition, the localization error can be within 1 m with more than 65% and 43% for Y-axis and X-axis, respectively. Finally, based on the results of the interference occurrence, the proposed PNN-based predictor for the interference arrival prediction can capture correctly the similar distribution function of the coming continuous idle status. en-copyright= kn-copyright= en-aut-name=HouYafei en-aut-sei=Hou en-aut-mei=Yafei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YanoKazuto en-aut-sei=Yano en-aut-mei=Kazuto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugaNorisato en-aut-sei=Suga en-aut-mei=Norisato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WebberJulian en-aut-sei=Webber en-aut-mei=Julian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DennoSatoshi en-aut-sei=Denno en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SakanoToshikazu en-aut-sei=Sakano en-aut-mei=Toshikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Wave Engineering Laboratories, Advanced Telecommunications Research Institute International kn-affil= affil-num=3 en-affil=Wave Engineering Laboratories, Advanced Telecommunications Research Institute International kn-affil= affil-num=4 en-affil=Wave Engineering Laboratories, Advanced Telecommunications Research Institute International kn-affil= affil-num=5 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=6 en-affil=Wave Engineering Laboratories, Advanced Telecommunications Research Institute International kn-affil= en-keyword=Interference detection kn-keyword=Interference detection en-keyword=MUSIC spectrum kn-keyword=MUSIC spectrum en-keyword=interference localization kn-keyword=interference localization en-keyword=prediction of interference arrival kn-keyword=prediction of interference arrival en-keyword=probabilistic neural network kn-keyword=probabilistic neural network END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=12 article-no= start-page=1888 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240614 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prognostic Implications of Insulin Resistance in Heart Failure in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Diabetes mellitus (DM) is a major risk and prognostic factor for heart failure (HF). Insulin resistance (IR) is an important component of DM, but the relationship between IR and HF prognosis has not yet been established across a wide variety of HF populations. We retrospectively evaluated the relationship between IR and clinical outcomes of HF patients at our hospital between 2017 and 2021. IR was defined as a homeostatic model assessment of IR (HOMA-IR) index >= 2.5, calculated from fasting blood glucose and insulin concentrations. The primary outcome was a composite of all-cause death and hospitalisation for HF (HHF). Among 682 patients included in the analyses, 337 (49.4%) had IR. The median age was 70 [interquartile range (IQR): 59-77] years old, and 66% of the patients were men. Among the patients, 41% had a left ventricular ejection fraction below 40%, and 32% had DM. The median follow-up period was 16.5 [IQR: 4.4-37.3] months. IR was independently associated with the primary outcome (HR: 1.91, 95% CI: 1.39-2.62, p < 0.0001), death (hazard ratio [HR]: 1.86, 95% confidence interval [CI]: 1.28-2.83, p < 0.01), and HHF (HR: 1.91, 95% CI: 1.28-2.83, p < 0.01). HOMA-IR is an independent prognostic factor of HF in a wide variety of HF populations. en-copyright= kn-copyright= en-aut-name=IwasakiKeiichiro en-aut-sei=Iwasaki en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamuraKazufumi en-aut-sei=Nakamura en-aut-mei=Kazufumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AkagiSatoshi en-aut-sei=Akagi en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakayaYoichi en-aut-sei=Takaya en-aut-mei=Yoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TodaHironobu en-aut-sei=Toda en-aut-mei=Hironobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiToru en-aut-sei=Miyoshi en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YuasaShinsuke en-aut-sei=Yuasa en-aut-mei=Shinsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Cardiovascular Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=heart failure kn-keyword=heart failure en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=HOMA-IR kn-keyword=HOMA-IR en-keyword=diabetes mellitus kn-keyword=diabetes mellitus END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=3 article-no= start-page=259 end-page=270 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Role of the Lipid Profile and Oxidative Stress in Fatigue, Sleep Disorders and Cognitive Impairment in Patients with Multiple Sclerosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of this study is to investigate the relationship of the lipid profile, dysfunctional high-density lipoprotein, ischaemia-modified albumin and thiol?disulfide homeostasis with cognitive impairment, fatigue and sleep disorders in patients with multiple sclerosis. The cognitive functions of patients were evaluated with the Brief International Cognitive Assessment for Multiple Sclerosis battery. Fatigue was evaluated with the Fatigue Severity Scale and the Fatigue Impact Scale. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were used to assess patients’ sleep disturbance. Peripheral blood samples were collected, and lipid levels and myeloperoxidase and paraoxonase activity were measured. The myeloperoxidase/paraoxonase ratio, which indicates dysfunctional high-density lipoprotein, was calculated. Thiol?disulfide homeostasis and ischaemia-modified albumin were measured.
We did not identify any relationship between dysfunctional high-density lipoprotein and the physical disability, cognitive decline, fatigue and sleep problems of multiple sclerosis. Thiol?disulfide homeostasis was associated with cognitive scores. The shift of the balance towards disulfide was accompanied by a decrease in cognitive scores. On the other hand, we did not detect any relationship between fatigue and sleep disorders and thiol?disulfide homeostasis. Our findings revealed a possible correlation between cognitive dysfunction and thiol?disulfide homeostasis in multiple sclerosis patients. en-copyright= kn-copyright= en-aut-name=VuralGonul en-aut-sei=Vural en-aut-mei=Gonul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DemirEsra en-aut-sei=Demir en-aut-mei=Esra kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=GumusyaylaSadiye en-aut-sei=Gumusyayla en-aut-mei=Sadiye kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ErenFunda en-aut-sei=Eren en-aut-mei=Funda kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=BarakliSerdar en-aut-sei=Barakli en-aut-mei=Serdar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NeseliogluSalim en-aut-sei=Neselioglu en-aut-mei=Salim kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ErelOzcan en-aut-sei=Erel en-aut-mei=Ozcan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Neurology, Faculty of Medicine, Ankara Yildirim Beyazit University kn-affil= affil-num=2 en-affil=Department of Neurology, Ankara City Hospital kn-affil= affil-num=3 en-affil=Department of Neurology, Faculty of Medicine, Ankara Yildirim Beyazit University kn-affil= affil-num=4 en-affil=Department of Clinical Biochemistry, Ankara City Hospital kn-affil= affil-num=5 en-affil=Department of Neurology, Ankara City Hospital kn-affil= affil-num=6 en-affil=Department of Clinical Biochemistry, Ankara City Hospital kn-affil= affil-num=7 en-affil=Department of Clinical Biochemistry, Ankara City Hospital kn-affil= en-keyword=multiple sclerosis kn-keyword=multiple sclerosis en-keyword=dysfunctional HDL kn-keyword=dysfunctional HDL en-keyword=thiol?disulfide homeostasis kn-keyword=thiol?disulfide homeostasis en-keyword=cognitive decline kn-keyword=cognitive decline END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=2 article-no= start-page=185 end-page=191 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=The global pandemic of coronavirus infection 2019 (COVID-19) was an unprecedented public health emergency. Several clinical studies reported that heart disease, lung disease, diabetes, hypertension, dyslipidemia, and obesity are critical risk factors for increased severity of and hospitalization for COVID-19. This is largely because patients with these underlying medical conditions can show poor immune responses to the COVID-19 vaccinations. Diabetes is one of the underlying conditions most highly associated with COVID-19 susceptibility and is considered a predictor of poor prognosis of COVID-19. We therefore investigated factors that influence the anti-SARS-CoV-2 spike IgG antibody titer after three doses of vaccination in patients with type 2 diabetes. We found that obesity was associated with low anti-SARS-CoV-2 spike IgG antibody titers following three-dose vaccination in type 2 diabetics. Obese patients with type 2 diabetes may have attenuated vaccine efficacy and require additional vaccination; continuous infection control should be considered in such patients. en-copyright= kn-copyright= en-aut-name=TakahashiHiroko en-aut-sei=Takahashi en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EguchiJun en-aut-sei=Eguchi en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatanabeMayu en-aut-sei=Watanabe en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakayamaMasanori en-aut-sei=Nakayama en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Office of Innovative Medicine, Organization for Research Strategy and Development, Okayama University kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=obesity kn-keyword=obesity en-keyword=type 2 diabetes kn-keyword=type 2 diabetes en-keyword=COVID-19 kn-keyword=COVID-19 en-keyword=vaccination kn-keyword=vaccination END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue=2 article-no= start-page=171 end-page=184 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=202404 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Relationships among Internalized Stigma, Sense of Coherence, and Personal Recovery of Persons with Schizophrenia Living in the Community en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated (i) the relationships among internalized stigma (IS), sense of coherence (SOC), and the personal recovery (PR) of persons with schizophrenia living in the community, and (ii) how to improve the support for these individuals. A questionnaire survey on IS, SOC, and PR was sent by mail to 270 persons with schizophrenia living in the community who were using psychiatric daycare services, of whom 149 responded and 140 were included in the analysis. We established a hypothetical model in which IS influences PR, and SOC influences IS and PR, and we used structural equation modeling to examine the relationships among these concepts. The goodness of fit was acceptable. Our findings suggest that rather than directly promoting PR, SOC promotes PR by mitigating the impact of IS. It is important for nurses/supporters to support individuals with schizophrenia living in the community so that they have opportunities to reflect on their own experiences through their activities and to share their experiences with peers. Nurses/supporters themselves should also reflect on their own support needs. Our findings suggest that this will lead to a reduction of IS and the improvement of SOC, which will in turn promote personal recovery. en-copyright= kn-copyright= en-aut-name=KuramotoAya en-aut-sei=Kuramoto en-aut-mei=Aya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SaitoShinya en-aut-sei=Saito en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=School of Nursing, Faculty of Medicine, Kagawa University kn-affil= en-keyword=schizophrenia kn-keyword=schizophrenia en-keyword=internalized stigma kn-keyword=internalized stigma en-keyword=sense of coherence kn-keyword=sense of coherence en-keyword=personal recovery kn-keyword=personal recovery en-keyword=community kn-keyword=community END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue=4 article-no= start-page=2772 end-page=2784 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Total Synthesis of the Proposed Structure of Indolyl 1,2-Propanediol Alkaloid, 1-(1H-Indol-3-yloxy)propan-2-ol en-subtitle= kn-subtitle= en-abstract= kn-abstract=The first total synthesis of the proposed structure of unprecedented indolyl derivative bearing 1,2-propanediol moiety is described. Isomerization of 3-alkoxyindolines through indolenium intermediates was the key step in the total synthesis. H-1, C-13-NMR, IR, and HRMS spectra of the synthetic compound drastically differed to those of the originally reported structure, which suggests the natural product requires revision. en-copyright= kn-copyright= en-aut-name=KimataMomoko en-aut-sei=Kimata en-aut-mei=Momoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AbeTakumi en-aut-sei=Abe en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=1-(1H-indol-3-yloxy)propan-2-ol kn-keyword=1-(1H-indol-3-yloxy)propan-2-ol en-keyword=indole alkaloid kn-keyword=indole alkaloid en-keyword=isomerization kn-keyword=isomerization en-keyword=silver kn-keyword=silver en-keyword=umpolung kn-keyword=umpolung END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=5 article-no= start-page=451 end-page=460 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=An Assessment Rubric for a Resident Training Program in Surgery: A Single-Institution Experience en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using a Collaborative Action Research model, our research team established a one-month clinical resident training program for first- and second-year clinical residents. We created and implemented an assessment rubric to assess the residents’ progress toward independent practice in surgery, and thereby, to evaluate the program itself. The program included training in three areas: basic techniques and procedures in the operating room, surgical ward management, and academic activities. The rubric measured the residents’ performance according to three achievement levels: Level 1 (demonstration), Level 2 (active help) and Level 3 (passive help). The program and rubric implementation began in June 2019 and continued until March 2020, when the program outcomes and shortcomings were analyzed. Among nineteen clinical residents, a total of nine clinical residents participated in the study. Most participants reached achievement Level 3 for their performance of basic techniques in the operating room. Finally, we discussed ideas for improvement and drafted plans for an improved rubric to complete the action research cycle. Our research team found the rubric to be a useful tool in evaluating the status of the new clinical resident training program. en-copyright= kn-copyright= en-aut-name=OkitaAtsushi en-aut-sei=Okita en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsukudaKazunori en-aut-sei=Tsukuda en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InoHideo en-aut-sei=Ino en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MitsuiEma en-aut-sei=Mitsui en-aut-mei=Ema kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IkeyaNanami en-aut-sei=Ikeya en-aut-mei=Nanami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamamotoSumiharu en-aut-sei=Yamamoto en-aut-mei=Sumiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YokoyamaNobuji en-aut-sei=Yokoyama en-aut-mei=Nobuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=BulinAubra en-aut-sei=Bulin en-aut-mei=Aubra kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Surgery, Okayama City Hospital kn-affil= affil-num=2 en-affil=Department of Surgery, Okayama City Hospital kn-affil= affil-num=3 en-affil=Center for Education in Medicine and Health Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Surgery, Okayama City Hospital kn-affil= affil-num=5 en-affil=Department of Surgery, Okayama City Hospital kn-affil= affil-num=6 en-affil=Department of Surgery, Okayama City Hospital kn-affil= affil-num=7 en-affil=Department of Surgery, Okayama City Hospital kn-affil= affil-num=8 en-affil=Discovery Program for Global Learners, Okayama University kn-affil= en-keyword=resident program kn-keyword=resident program en-keyword=rubric assessment kn-keyword=rubric assessment en-keyword=general surgery kn-keyword=general surgery en-keyword=action research kn-keyword=action research END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=6 article-no= start-page=3300 end-page=3308 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220126 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Flame retardance-donated lignocellulose nanofibers (LCNFs) by the Mannich reaction with (amino-1,3,5-triazinyl)phosphoramidates and their properties en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nitrogen/phosphorus-containing melamines (NPCM), a durable flame-retardant, were prepared by the successive treatment of ArOH (Ar = BrnC6H5?n, n = 0, 1, 2, and 3) with POCl3 and melamine monomer. The prepared flame-retardants were grafted through the CH2 unit to lignocellulose nanofibers (LCNFs) by the Mannich reaction. The resulting three-component products were characterized using FT-IR (ATR) and EA. The thermal behavior of the NPCM-treated LCNF fabric samples was determined using TGA and DSC analyses, and their flammability resistances were evaluated by measuring their Limited Oxygen Index (LOI) and the UL-94V test. A multitude of flame retardant elements in the fabric samples increased the LOI values as much as 45 from 20 of the untreated LCNFs. Moreover, the morphology of both the NPCM-treated LCNFs and their burnt fabrics was studied with a scanning electron microscope (SEM). The heat release lowering effect of the LCNF fabric against the water-based paint was observed with a cone calorimeter. Furthermore, the mechanical properties represented as the tensile strength of the NPCM-treated LCNF fabrics revealed that the increase of the NPCM content in the PP-composites led to an increased bending strength with enhancing the flame-retardance. en-copyright= kn-copyright= en-aut-name=OnoFumiaki en-aut-sei=Ono en-aut-mei=Fumiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkiharaTakumi en-aut-sei=Okihara en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OsakaNoboru en-aut-sei=Osaka en-aut-mei=Noboru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NagaokaNoriyuki en-aut-sei=Nagaoka en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KameokaYuji en-aut-sei=Kameoka en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshikawaAkira en-aut-sei=Ishikawa en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OokiHironari en-aut-sei=Ooki en-aut-mei=Hironari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ItoTakumi en-aut-sei=Ito en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TodomeDaisuke en-aut-sei=Todome en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=UemotoShinya en-aut-sei=Uemoto en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FurutaniMitsuaki en-aut-sei=Furutani en-aut-mei=Mitsuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=InokuchiTsutomu en-aut-sei=Inokuchi en-aut-mei=Tsutomu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OkadaKenji en-aut-sei=Okada en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Okayama Biomass Innovation Creative Center kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Science, Okayama University of Science kn-affil= affil-num=4 en-affil=Advanced Research Center for Oral and Craniofacial Science, Okayama University Dental School kn-affil= affil-num=5 en-affil=Marubishi Oil Chemical Co., Ltd kn-affil= affil-num=6 en-affil=Marubishi Oil Chemical Co., Ltd kn-affil= affil-num=7 en-affil=Gen Gen Corporation kn-affil= affil-num=8 en-affil=Gen Gen Corporation kn-affil= affil-num=9 en-affil=Faculty of Science, Okayama University of Science kn-affil= affil-num=10 en-affil=Okayama Biomass Innovation Creative Center kn-affil= affil-num=11 en-affil=Okayama Biomass Innovation Creative Center kn-affil= affil-num=12 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=13 en-affil=Department of Life Science, Kurashiki University of Science & the Arts kn-affil= END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230329 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Hydrogen gas treatment improves survival in a rat model of crush syndrome by ameliorating rhabdomyolysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objectives: Crush syndrome (CS) is characterized by a systemic manifestation of traumatic rhabdomyolysis, leading to multiple organ dysfunction and death. Ischemia-reperfusion (IR) injury is commonly responsible for systemic response. Extending studies have shown that hydrogen gas treatment ameliorated IR injury in numerous experimental models; however, its effect on CS has not been well examined. This study aimed to investigate the effects of hydrogen gas inhalation following crush injury in an experimental model of CS.
Methods: Male Sprague-Dawley rats were subjected to experimental CS by applying a total of 3.0 kg weight to both hindlimb under general anesthesia for 6 h. Immediately after decompression, the animals were randomly placed in a gas chamber filled with either air or 1.3% hydrogen gas. Animals were sacrificed 18 h or 24 h following gas exposure for non-survival studies or for survival study, respectively.
Results: The rats with hydrogen treatment (n = 6) had a higher 24-h survival than the rats with air treatment (n = 9) (100% vs. 44%, p = 0.035). Lactate concentrations (2.9 +/- 0.2 vs. 2.2 +/- 0.2 mmol/L, p = 0.040) and creatine kinase (34,178 +/- 13,580 vs. 5005 +/- 842 IU/L, p = 0.016) were lower in the hydrogen group compared with the air group 18 h after decompression (n = 4 in the air group, and n = 5 in the H-2 group). Histological analysis revealed that the damage to the rectus femoris muscle and kidney appeared to be ameliorated by hydrogen treatment.
Conclusion: Hydrogen gas inhalation may be a promising therapeutic approach in the treatment of CS. en-copyright= kn-copyright= en-aut-name=YumotoTetsuya en-aut-sei=Yumoto en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AokageToshiyuki en-aut-sei=Aokage en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HirayamaTakahiro en-aut-sei=Hirayama en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamamotoHirotsugu en-aut-sei=Yamamoto en-aut-mei=Hirotsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ObaraTakafumi en-aut-sei=Obara en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NojimaTsuyoshi en-aut-sei=Nojima en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Crush syndrome kn-keyword=Crush syndrome en-keyword=experimental model kn-keyword=experimental model en-keyword=hydrogen kn-keyword=hydrogen en-keyword=ischemia kn-keyword=ischemia en-keyword=reperfusion injury kn-keyword=reperfusion injury END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=2 article-no= start-page=193 end-page=197 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Validity of the 30-Second Chair-Stand Test to Assess Exercise Tolerance and Clinical Outcomes in Patients with Esophageal Cancer: A Retrospective Study with Reference to 6-Minute Walk Test Results en-subtitle= kn-subtitle= en-abstract= kn-abstract=This retrospective study aimed to investigate the validity of a 30-sec chair stand test (CS-30) as a simple test to assess exercise tolerance and clinical outcomes in 53 Japanese patients with esophageal cancer. There was a strong correlation between the results of CS-30 and the 6-min walk test (6MWT), the gold standard for assessing exercise tolerance (r=0.759). Furthermore, fewer patients whose CS-30 score was greater than 16 (the cutoff value defined based on 6MWT) experienced pneumonia in their postoperative course. These results suggest that exercise tolerance could be assessed using CS-30, and its cutoff value may be useful in predicting postoperative pneumonia risk. en-copyright= kn-copyright= en-aut-name=IkedaTomohiro en-aut-sei=Ikeda en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkuraKazuki en-aut-sei=Okura en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KatayamaSho en-aut-sei=Katayama en-aut-mei=Sho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakahashiYusuke en-aut-sei=Takahashi en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MaedaNaoaki en-aut-sei=Maeda en-aut-mei=Naoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WakitaAkiyuki en-aut-sei=Wakita en-aut-mei=Akiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HamadaMasanori en-aut-sei=Hamada en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SendaMasuo en-aut-sei=Senda en-aut-mei=Masuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Rehabilitation Medicine, Okayama University kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Division of Rehabilitation, Akita University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Rehabilitation Medicine, Okayama University kn-affil= affil-num=5 en-affil=Division of Rehabilitation, Akita University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Esophageal Surgery, Akita University Graduate School of Medicine kn-affil= affil-num=9 en-affil=Department of Rehabilitation Medicine, Okayama University kn-affil= affil-num=10 en-affil=Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Rehabilitation Medicine, Okayama University kn-affil= en-keyword=esophageal cancer kn-keyword=esophageal cancer en-keyword=exercise tolerance kn-keyword=exercise tolerance en-keyword=rehabilitation kn-keyword=rehabilitation END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=1 article-no= start-page=111 end-page=116 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202302 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Osteonecrosis of the Jaw in Two Rheumatoid Arthritis Patients Not Treated with a Bisphosphonate en-subtitle= kn-subtitle= en-abstract= kn-abstract=Medication-related osteonecrosis of the jaw (MRONJ) is a side effect in patients taking bone-modifying agents (BMAs), which are highly beneficial for treating osteoporosis and cancer. Bisphosphonates are prescribed to treat secondary osteoporosis in patients with rheumatoid arthritis (RA). We recently encountered two unusual cases of intraoral ONJ in RA patients who had not been treated with a BMA and did not have features of methotrexate- associated lymphoproliferative disorder. Their ONJ stage II bone exposures were treated by conservative therapy, providing good prognoses. These cases indicate that ONJ can occur in RA patients not treated with bisphosphonates. Several risk factors are discussed. en-copyright= kn-copyright= en-aut-name=AmanoKatsuhiko en-aut-sei=Amano en-aut-mei=Katsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SugauchiAkinari en-aut-sei=Sugauchi en-aut-mei=Akinari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamadaChiaki en-aut-sei=Yamada en-aut-mei=Chiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KogoMikihiko en-aut-sei=Kogo en-aut-mei=Mikihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IidaSeiji en-aut-sei=Iida en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=The first department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry kn-affil= affil-num=3 en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=The first department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry kn-affil= affil-num=5 en-affil=Department of Oral and Maxillofacial Reconstructive Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=osteonecrosis of the jaw kn-keyword=osteonecrosis of the jaw en-keyword=rheumatoid arthritis kn-keyword=rheumatoid arthritis en-keyword=risk factor kn-keyword=risk factor en-keyword=bisphosphonate kn-keyword=bisphosphonate END start-ver=1.4 cd-journal=joma no-vol=77 cd-vols= no-issue=1 article-no= start-page=45 end-page=55 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=202302 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Image Quality Assessment of Deep Learning Image Reconstruction in Torso Computed Tomography Using Tube Current Modulation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Novel deep learning image reconstruction (DLIR) reportedly changes the image quality characteristics based on object contrast and image noise. In clinical practice, computed tomography image noise is usually controlled by tube current modulation (TCM) to accommodate changes in object size. This study aimed to evaluate the image quality characteristics of DLIR for different object sizes when the in-plane noise was controlled by TCM. Images acquisition was performed on a GE Revolution CT system to investigate the impact of the DLIR algorithm compared to the standard reconstructions of filtered-back projection (FBP) and hybrid iterative reconstruction (hybrid-IR). The image quality assessment was performed using phantom images, and an observer study was conducted using clinical cases. The image quality assessment confirmed the excellent noise- reduction performance of DLIR, despite variations due to phantom size. Similarly, in the observer study, DLIR received high evaluations regardless of the body parts imaged. We evaluated a novel DLIR algorithm by replicating clinical behaviors. Consequently, DLIR exhibited higher image quality than those of FBP and hybrid-IR in both phantom and observer studies, albeit the value depended on the reconstruction strength, and proved itself capable of providing stable image quality in clinical use. en-copyright= kn-copyright= en-aut-name=TakeuchiKazuhiro en-aut-sei=Takeuchi en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IdeYasuhiro en-aut-sei=Ide en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoriYuichiro en-aut-sei=Mori en-aut-mei=Yuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UeharaYusuke en-aut-sei=Uehara en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SukeishiHiroshi en-aut-sei=Sukeishi en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GotoSachiko en-aut-sei=Goto en-aut-mei=Sachiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Radiology, Kagawa University Hospital kn-affil= affil-num=2 en-affil=Department of Radiology, Kagawa University Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Kagawa University Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Kagawa University Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Kagawa University Hospital kn-affil= affil-num=6 en-affil=Department of Radiological Technology, Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=computed tomography kn-keyword=computed tomography en-keyword=deep learning kn-keyword=deep learning en-keyword=image reconstruction kn-keyword=image reconstruction en-keyword=tube current modulation kn-keyword=tube current modulation en-keyword=object size kn-keyword=object size END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=11 article-no= start-page=673 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20221110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung en-subtitle= kn-subtitle= en-abstract= kn-abstract=(1) Background: Lung ischemia-reperfusion (IR) injury increases the mortality and morbidity of patients undergoing lung transplantation. The objective of this study was to identify the key initiator of lung IR injury and to evaluate pharmacological therapeutic approaches using a functional inhibitor against the identified molecule. (2) Methods: Using a mouse hilar clamp model, the combination of RNA sequencing and histological investigations revealed that neutrophil-derived S100A8/A9 plays a central role in inflammatory reactions during lung IR injury. Mice were assigned to sham and IR groups with or without the injection of anti-S100A8/A9 neutralizing monoclonal antibody (mAb). (3) Results: Anti-S100A8/A9 mAb treatment significantly attenuated plasma S100A8/A9 levels compared with control IgG. As evaluated by oxygenation capacity and neutrophil infiltration, the antibody treatment dramatically ameliorated the IR injury. The gene expression levels of cytokines and chemokines induced by IR injury were significantly reduced by the neutralizing antibody. Furthermore, the antibody treatment significantly reduced TUNEL-positive cells, indicating the presence of apoptotic cells. (4) Conclusions: We identified S100A8/A9 as a novel therapeutic target against lung IR injury. en-copyright= kn-copyright= en-aut-name=NakataKentaro en-aut-sei=Nakata en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkazakiMikio en-aut-sei=Okazaki en-aut-mei=Mikio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakaueTomohisa en-aut-sei=Sakaue en-aut-mei=Tomohisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KinoshitaRie en-aut-sei=Kinoshita en-aut-mei=Rie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KomodaYuhei en-aut-sei=Komoda en-aut-mei=Yuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShimizuDai en-aut-sei=Shimizu en-aut-mei=Dai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamamotoHaruchika en-aut-sei=Yamamoto en-aut-mei=Haruchika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanakaShin en-aut-sei=Tanaka en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SuzawaKen en-aut-sei=Suzawa en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ShienKazuhiko en-aut-sei=Shien en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MiyoshiKentaroh en-aut-sei=Miyoshi en-aut-mei=Kentaroh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamamotoHiromasa en-aut-sei=Yamamoto en-aut-mei=Hiromasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=SugimotoSeiichiro en-aut-sei=Sugimoto en-aut-mei=Seiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=YamaneMasaomi en-aut-sei=Yamane en-aut-mei=Masaomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=MatsukawaAkihiro en-aut-sei=Matsukawa en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=SakaguchiMasakiyo en-aut-sei=Sakaguchi en-aut-mei=Masakiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= affil-num=1 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine kn-affil= affil-num=6 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network kn-affil= affil-num=8 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=16 en-affil= Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=17 en-affil=Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=18 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=ischemia reperfusion injury kn-keyword=ischemia reperfusion injury en-keyword= S100A8/A9 kn-keyword= S100A8/A9 en-keyword=lung transplantation kn-keyword=lung transplantation en-keyword=damage-associated molecule patterns kn-keyword=damage-associated molecule patterns END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=6 article-no= start-page=689 end-page=694 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=An Evaluation of the Efficacy of Compression Therapy Using Sleeves and Stockings to Prevent Docetaxel-induced Peripheral Neuropathy in Breast Cancer Patients en-subtitle= kn-subtitle= en-abstract= kn-abstract=Taxanes are key drugs for patients with breast cancer. A major adverse effect of taxanes is peripheral neuropathy (PN). To investigate the ability of compression therapy using sleeves and stockings to prevent PN due to the taxane docetaxel, we conducted a single-center historical control trial. Patients receiving docetaxel at 75 mg/m2 every 3 weeks for 4 cycles as first-line chemotherapy for breast cancer were eligible. PN was evaluated using the common terminology criteria for adverse events version 4.0. The primary endpoint was the incidence of allgrade PN until 3 weeks after the fourth docetaxel administration. We evaluated 26 patients in the intervention group and compared their data to those collected retrospectively from 52 patients treated with docetaxel without compression. Neither the incidence of all-grade PN until 3 weeks after the fourth docetaxel administration (63.5% in the control group vs. 76.9% in the intervention group, p=0.31) nor that of PN grade ? 2 (13.5% vs. 15.4%, p=0.99) differed between the groups. In this study, the efficacy of compression therapy using sleeves and stockings to prevent PN induced by docetaxel was not demonstrated. Further clinical studies including medications or intervention are needed to reduce the incidence and severity of PN induced by chemotherapy. en-copyright= kn-copyright= en-aut-name=YamanouchiKosho en-aut-sei=Yamanouchi en-aut-mei=Kosho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KubaSayaka en-aut-sei=Kuba en-aut-mei=Sayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsumotoMegumi en-aut-sei=Matsumoto en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YanoHiroshi en-aut-sei=Yano en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoritaMichi en-aut-sei=Morita en-aut-mei=Michi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SakimuraChika en-aut-sei=Sakimura en-aut-mei=Chika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OtsuboRyota en-aut-sei=Otsubo en-aut-mei=Ryota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HidakaMasaaki en-aut-sei=Hidaka en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NagayasuTakeshi en-aut-sei=Nagayasu en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=EguchiSusumu en-aut-sei=Eguchi en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=2 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=3 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=4 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=5 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=6 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=7 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=8 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=9 en-affil=Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Science kn-affil= affil-num=10 en-affil=Department of Surgery, Nagasaki University Graduate School of Biomedical Science kn-affil= en-keyword=breast cancer kn-keyword=breast cancer en-keyword=docetaxel kn-keyword=docetaxel en-keyword=neuropathy kn-keyword=neuropathy en-keyword=compression kn-keyword=compression END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=5 article-no= start-page=511 end-page=517 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Model-Based Iterative Reconstruction in Low-Dose Paranasal Computed Tomography: A Comparison with Filtered Back Projection and Hybrid Iterative Reconstruction en-subtitle= kn-subtitle= en-abstract= kn-abstract=Iterative reconstruction (IR) improves image quality compared with filtered back projection (FBP). This study investigated the usefulness of model-based IR (forward-projected model-based iterative reconstruction solution [FIRST]) in comparison with FBP and hybrid IR (adaptive iterative dose reduction three-dimensional processing [AIDR 3D]) in low-dose paranasal CT. Twenty-four patients with paranasal sinusitis who underwent standard-dose CT (120 kV) and low-dose CT (100 kV) scanning before and after medical treatment were enrolled. Standard-dose CT scans were reconstructed with FBP (FBP120), and low-dose CT scans with FBP (FBP100), AIDR 3D, and FIRST. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in three anatomical structures and effective doses were compared using Mann?Whitney U test. Two radiologists independently evaluated the visibility of 16 anatomical structures, overall image quality, and artifacts. Effective doses in lowdose CT were significantly reduced compared with those in standard-dose CT (0.24 vs 0.43 mSv, p<0.001). FIRST achieved significantly higher SNR (p<0.01, respectively) and CNR (p<0.001, respectively) of evaluated structures and significant improvement in overall image quality (p<0.001), artifacts (p<0.001), and visibility related to muscles (p<0.05) compared to FBP120, FBP100, and AIDR 3D. FIRST allowed radiation-dose reduction, while maintaining objective and subjective image quality in low-dose paranasal CT. en-copyright= kn-copyright= en-aut-name=TomitaHayato en-aut-sei=Tomita en-aut-mei=Hayato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KuramochiKenji en-aut-sei=Kuramochi en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujikawaAtsuko en-aut-sei=Fujikawa en-aut-mei=Atsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkedaHirotaka en-aut-sei=Ikeda en-aut-mei=Hirotaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KomitaMidori en-aut-sei=Komita en-aut-mei=Midori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KuriharaYoshiko en-aut-sei=Kurihara en-aut-mei=Yoshiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MimuraHidefumi en-aut-sei=Mimura en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Radiology, St. Marianna University School of Medicine kn-affil= affil-num=2 en-affil=Department of Radiology, St. Marianna University School of Medicine kn-affil= affil-num=3 en-affil=Department of Radiology, St. Marianna University School of Medicine kn-affil= affil-num=4 en-affil=Department of Radiology, Fujita Health University School of Medicine kn-affil= affil-num=5 en-affil=Department of Radiology, St. Marianna University School of Medicine kn-affil= affil-num=6 en-affil=Department of Radiology, Machida Municipal Hospital kn-affil= affil-num=7 en-affil=Department of Advanced Biomedical Imaging Informatics, St. Marianna University School of Medicine kn-affil= affil-num=8 en-affil=Department of Radiology, St. Marianna University School of Medicine kn-affil= en-keyword=paranasal sinuses kn-keyword=paranasal sinuses en-keyword=iterative reconstruction kn-keyword=iterative reconstruction en-keyword=dose reduction kn-keyword=dose reduction en-keyword=low dose kn-keyword=low dose END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=5 article-no= start-page=503 end-page=510 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202210 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Viral Sequences Are Repurposed for Controlling Antiviral Responses as Non-Retroviral Endogenous Viral Elements en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eukaryotic genomes contain numerous copies of endogenous viral elements (EVEs), most of which are considered endogenous retrovirus (ERV) sequences. Over the past decade, non-retroviral endogenous viral elements (nrEVEs) derived from ancient RNA viruses have been discovered. Several functions have been proposed for these elements, including antiviral defense. This review summarizes the current understanding of nrEVEs derived from RNA viruses, particularly endogenous bornavirus-like elements (EBLs) and endogenous filovirus-like elements (EFLs). EBLs are one of the most extensively studied nrEVEs. The EBL derived from bornavirus nucleoprotein (EBLN) is thought to function as a non-coding RNA or protein that regulates host gene expression or inhibits virus propagation. Ebolavirus and marburgvirus, which are filoviruses, induce severe hemorrhagic fever in humans and nonhuman primates. Although the ecology of filoviruses remains unclear, bats are believed to be potential reservoirs. Based on the knowledge from EBLs, it is postulated that EFLs in the bat genome help to maintain the balance between filovirus infection and the bat’s defense system, which may partially explain why bats act as potential reservoirs. Further research into the functions of nrEVEs could reveal novel antiviral systems and inspire novel antiviral approaches. en-copyright= kn-copyright= en-aut-name=OgawaHirohito en-aut-sei=Ogawa en-aut-mei=Hirohito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HondaTomoyuki en-aut-sei=Honda en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Virology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Virology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=EVE kn-keyword=EVE en-keyword=nrEVE kn-keyword=nrEVE en-keyword=bornavirus kn-keyword=bornavirus en-keyword=filovirus kn-keyword=filovirus en-keyword=antiviral kn-keyword=antiviral END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue= article-no= start-page=1055 end-page=1061 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220819 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Electrochemical hydrogenation of enones using a proton- exchange membrane reactor: selectivity and utility en-subtitle= kn-subtitle= en-abstract= kn-abstract=Electrochemical hydrogenation of enones using a proton-exchange membrane reactor is described. The reduction of enones proceeded smoothly under mild conditions to afford ketones or alcohols. The reaction occurred chemoselectively with the use of different cathode catalysts (Pd/C or Ir/C). en-copyright= kn-copyright= en-aut-name=MitsudoKoichi en-aut-sei=Mitsudo en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=InoueHaruka en-aut-sei=Inoue en-aut-mei=Haruka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NikiYuta en-aut-sei=Niki en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SatoEisuke en-aut-sei=Sato en-aut-mei=Eisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugaSeiji en-aut-sei=Suga en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=enone kn-keyword=enone en-keyword=hydrogenation kn-keyword=hydrogenation en-keyword=iridium kn-keyword=iridium en-keyword=palladium kn-keyword=palladium en-keyword=PEM reactor kn-keyword=PEM reactor END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=3 article-no= start-page=265 end-page=271 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202206 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Impact of Medical Students Teaching Basic Life Support to Laypersons en-subtitle= kn-subtitle= en-abstract= kn-abstract=Basic life support (BLS) courses for laypersons, including cardiopulmonary resuscitation (CPR) training, is known to improve outcomes of out-of-hospital cardiac events. We asked medical students to provide BLS training for laypersons as a part of their emergency medicine education and evaluated the effects of training on the BLS skills of laypersons. We also used a questionnaire to determine whether the medical students who provided the BLS training were themselves more confident and motivated to perform BLS compared to students who did not provide BLS training. The proportions of laypersons who reported confidence in checking for a response, performing chest compressions, and automated external defibrillator (AED) use were significantly increased after the BLS training. The proportions of medical students who reported increased confidence/motivation in terms of understanding BLS, checking for a response, chest compression, use of AED, and willingness to perform BLS were significantly greater among medical students who provided BLS instructions compared to those who did not. BLS instruction by medical students was associated with an improvement in laypersons’ CPR accuracy and confidence in responding to cardiac arrest. The results indicate that medical students could gain understanding, confidence, and motivation in regard to their BLS skills by teaching BLS to laypersons. en-copyright= kn-copyright= en-aut-name=KosakiYoshinori en-aut-sei=Kosaki en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IidaAtsuyoshi en-aut-sei=Iida en-aut-mei=Atsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IhoriyaHiromi en-aut-sei=Ihoriya en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NojimaTsuyoshi en-aut-sei=Nojima en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamadaTaihei en-aut-sei=Yamada en-aut-mei=Taihei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamamotoHirotsugu en-aut-sei=Yamamoto en-aut-mei=Hirotsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakamuraShunsuke en-aut-sei=Nakamura en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MandaiYasuhiro en-aut-sei=Mandai en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Emergency Medicine, Japanese Red Cross Okayama Hospital kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Emergency Medicine, The JIKEI University kn-affil= affil-num=10 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=BLS kn-keyword=BLS en-keyword=medical education kn-keyword=medical education en-keyword=emergency medicine kn-keyword=emergency medicine en-keyword=resuscitation kn-keyword=resuscitation END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1 article-no= start-page=51 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=202202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Obesity’s Influence on Insulin Resistance in Pregnant Women with Polycystic Ovary Syndrome en-subtitle= kn-subtitle= en-abstract= kn-abstract=Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder that is associated with high insulin resistance and obesity. However, ~70% of women with PCOS in Japan are non-obese. We retrospectively analyzed the cases of 163 Japanese women with PCOS who visited our Ob/Gyn department in 2006-2018 to determine which has a greater effect on insulin resistance: PCOS or obesity. We reviewed the women’s medical records and calculated their insulin resistance and insulin secretion. The women’s mean age and pre-pregnancy body mass index (BMI) were 30±5.8 years and 24.8±5.6 kg/m2, respectively; their mean ± SD fasting plasma glucose, 94.1±13.7 mg/dL; HOMA-IR, 2.1±2.0; QUICKI, 0.4±0.0; and HOMA-β, 108.9±88.0%. Sixtyeight women were pregnant, and 37% (n=25) were obese (BMI ? 25 kg/m2). Obesity had a greater effect on insulin resistance: fasting plasma glucose F(1, 53)=6.134, p<0.05; fasting insulin F(1, 53)=31.606, p<0.01; HOMA-IR F(1, 53)=31.670, p<0.01; QUICKI F(1, 53)=16.156, p<0.01. There was no significant difference in values other than QUICKI and testosterone between the women with and without PCOS. Obesity thus had a greater effect on increased insulin resistance in pregnant women with PCOS. Further studies of the insulin resistance of non-obese women with PCOS is needed, as non-obese women with PCOS are common in Asia. en-copyright= kn-copyright= en-aut-name=EtoEriko en-aut-sei=Eto en-aut-mei=Eriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaniKazumasa en-aut-sei=Tani en-aut-mei=Kazumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MakiJota en-aut-sei=Maki en-aut-mei=Jota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HayataKei en-aut-sei=Hayata en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MasuyamaHisashi en-aut-sei=Masuyama en-aut-mei=Hisashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=polycystic ovary syndrome kn-keyword=polycystic ovary syndrome en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=obesity kn-keyword=obesity en-keyword=pregnancy kn-keyword=pregnancy END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=6 article-no= start-page=741 end-page=744 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Sublingual Gland Carcinoma Revealed by Choroidal Metastasis en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 65-year-old man presented with a 1-week history of left eye distortion. An elevated choroidal lesion covering 6 disc diameters was found in the posterior retina of the left eye. Systemic examination revealed sublingual gland carcinoma and multiple lung metastases, and the diagnosis was choroidal metastasis from sublingual gland carcinoma. Following chemotherapy and radiation therapy, the choroidal lesion shrunk and the patient’s visual acuity improved. The patient died 23 months after his first visit. To the best of our knowledge, this is the first reported case of choroidal metastasis from sublingual gland carcinoma. en-copyright= kn-copyright= en-aut-name=MoritaTetsuro en-aut-sei=Morita en-aut-mei=Tetsuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShiodeYusuke en-aut-sei=Shiode en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimuraShuhei en-aut-sei=Kimura en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HosokawaMio en-aut-sei=Hosokawa en-aut-mei=Mio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=DoiShinichiro en-aut-sei=Doi en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakahashiKosuke en-aut-sei=Takahashi en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatobaRyo en-aut-sei=Matoba en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KanzakiYuki en-aut-sei=Kanzaki en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TabataMasahiro en-aut-sei=Tabata en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MorizaneYuki en-aut-sei=Morizane en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Center for Clinical Oncology, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=adenoid cystic carcinoma kn-keyword=adenoid cystic carcinoma en-keyword=choroidal metastasis kn-keyword=choroidal metastasis en-keyword=sublingual gland kn-keyword=sublingual gland END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=1 article-no= start-page=18 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211023 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis and characterization of conductive flexible cellulose carbon nanohorn sheets for human tissue applications en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background
Conductive sheets of cellulose and carbon nanomaterials and its human skin applications are an interesting research aspect as they have potential for applications for skin compatibility. Hence it is needed to explore the effects and shed light on these applications.
Method
To fabricate wearable, portable, flexible, lightweight, inexpensive, and biocompatible composite materials, carbon nanohorns (CNHs) and hydroxyethylcellulose (HEC) were used as precursors to prepare CNH-HEC (Cnh-cel) composite sheets. Cnh-cel sheets were prepared with different loading concentrations of CNHs (10, 20 50,100mg) in 200mg cellulose. To fabricate the bio-compatible sheets, a pristine composite of CNHs and HEC was prepared without any pretreatment of the materials.
Results
The obtained sheets possess a conductivity of 1.83x10(-10)S/m and bio-compatible with human skin. Analysis for skin-compatibility was performed for Cnh-cel sheets by h-CLAT in vitro skin sensitization tests to evaluate the activation of THP-1 cells. It was found that THP-1 cells were not activated by Cnh-cel; hence Cnh-cel is a safe biomaterial for human skin. It was also found that the composite allowed only a maximum loading of 100mg to retain the consistent geometry of free-standing sheets of <100m thickness. Since CNHs have a unique arrangement of aggregates (dahlia structure), the composite is homogeneous, as verified by transmission electron microscopy (TEM) and, scanning electron microscopy (SEM), and other functional properties investigated by Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), conductivity measurement, tensile strength measurement, and skin sensitization.
Conclusion
It can be concluded that cellulose and CNHs sheets are conductive and compatible to human skin applications. en-copyright= kn-copyright= en-aut-name=SelvamKarthik Paneer en-aut-sei=Selvam en-aut-mei=Karthik Paneer kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NagahataTaichi en-aut-sei=Nagahata en-aut-mei=Taichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KatoKosuke en-aut-sei=Kato en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KoreishiMayuko en-aut-sei=Koreishi en-aut-mei=Mayuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakamuraToshiyuki en-aut-sei=Nakamura en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakamuraYoshimasa en-aut-sei=Nakamura en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NishikawaTakeshi en-aut-sei=Nishikawa en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SatohAyano en-aut-sei=Satoh en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HayashiYasuhiko en-aut-sei=Hayashi en-aut-mei=Yasuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=8 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=9 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Carbon Nanohorns kn-keyword=Carbon Nanohorns en-keyword=Cellulose kn-keyword=Cellulose en-keyword=Skin sensitization kn-keyword=Skin sensitization en-keyword=Composites kn-keyword=Composites en-keyword=Bio-compatible kn-keyword=Bio-compatible END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3 article-no= start-page=323 end-page=334 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202106 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Gender Expression among Transgender Women in Japan: Support Is Needed to Improve Social Passing as a Woman en-subtitle= kn-subtitle= en-abstract= kn-abstract=Gender expression is important for transgender women to improve their social passing as women. Herein, a questionnaire about the status of gender expression and support needs was distributed to 54 transgender women aged 17-71 in Japan. Most of the respondents noted that they had found it relatively difficult to handle physical changes and weight gain due to hormone treatment. They also found it difficult to enact and sustain practices such as a feminine use of voice and to use women-only services, whereas practicing and continuing with routine skin and hair care and feminine mannerisms were relatively easy for them. In the questionnaire regarding the support for gender transitioning, many items showed only a small percentage of the transgender women had received the support that they were looking for, and most of their needs for support were not addressed. Some of the factors that increased the respondents’ needs and achievement of gender expression as women included estrogen treatment, sex reassignment surgery, and living as a woman; these aspects met their support needs as well. Gender support professionals need to coordinate and collaborate with specialists in areas such as nutritional guidance and voice training to enable transgender women to improve the extent to which they can socially ‘pass’ as women. en-copyright= kn-copyright= en-aut-name=FurutaniMichiyo en-aut-sei=Furutani en-aut-mei=Michiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YuZhou en-aut-sei=Yu en-aut-mei=Zhou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakatsukaMikiya en-aut-sei=Nakatsuka en-aut-mei=Mikiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= en-keyword=transgender kn-keyword=transgender en-keyword=gender expression kn-keyword=gender expression en-keyword=social passing as a woman kn-keyword=social passing as a woman en-keyword=real life experience kn-keyword=real life experience en-keyword=gender transition kn-keyword=gender transition END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=2 article-no= start-page=231 end-page=238 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Long-term Survival with a Rare Advanced Primary Gastrointestinal Malignant Melanoma Treated with Laparoscopic Surgery/Immune Checkpoint Inhibitor en-subtitle= kn-subtitle= en-abstract= kn-abstract=Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma. en-copyright= kn-copyright= en-aut-name=EndoMotochika en-aut-sei=Endo en-aut-mei=Motochika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YanoShuya en-aut-sei=Yano en-aut-mei=Shuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AsanoHiroaki en-aut-sei=Asano en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakedaSho en-aut-sei=Takeda en-aut-mei=Sho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HamadaYuki en-aut-sei=Hamada en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KondoYoshitaka en-aut-sei=Kondo en-aut-mei=Yoshitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KurodaShinji en-aut-sei=Kuroda en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShigeyasuKunitoshi en-aut-sei=Shigeyasu en-aut-mei=Kunitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KikuchiSatoru en-aut-sei=Kikuchi en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TeraishiFuminori en-aut-sei=Teraishi en-aut-mei=Fuminori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=NishizakiMasahiko en-aut-sei=Nishizaki en-aut-mei=Masahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=KagawaShunsuke en-aut-sei=Kagawa en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Surgery, Mitoyo general Hospital kn-affil= affil-num=4 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Pathology, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=14 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=primary gastrointestinal melanoma kn-keyword=primary gastrointestinal melanoma en-keyword=laparoscopic surgery kn-keyword=laparoscopic surgery en-keyword=immune checkpoint antibody-blockade inhibitor kn-keyword=immune checkpoint antibody-blockade inhibitor END start-ver=1.4 cd-journal=joma no-vol=28 cd-vols= no-issue=4 article-no= start-page=1157 end-page=1169 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20214 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=HIF-1 alpha controls palatal wound healing by regulating macrophage motility via S1P/S1P(1) signaling axis kn-title=HIF‐1α controls palatal wound healing by regulating macrophage motility via S1P/S1P1 signaling axis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objectives
To investigate the role of hypoxia-inducible factor 1 alpha (HIF-1 alpha) signaling, the expression profile of M1 and M2 macrophages, and the role of the sphingosine 1-phosphate (S1P)/S1P receptor system in palatal wound healing of heterozygous HIF-1 alpha-deficient (HIF-1 alpha HET) mice. Materials and methods HIF-1 alpha HET and wild-type (WT) littermates underwent palatal tissue excision at the mid-hard palate. Histological analysis, immunostaining, real-time PCR, Western blotting (WB), and cellular migration assays were performed to analyze wound closure and macrophage infiltration.

Results
DMOG pretreatment showed an acceleration of palatal wound closure in WT mice. In contrast, the delayed palatal wound closure was observed in HIF-1 alpha HET mice with diminished production of Col1a1, MCP-1, and MIP-1 alpha, compared with WT mice. Decreased infiltration of M1 macrophage (F4/80(+)TNF-alpha(+), F4/80(+)iNOS(+)) and M2 macrophage (F4/80(+)Arginase-1(+), F4/80(+)CD163(+)) was observed. The numbers of F4/80(+)S1P(1)(+) macrophages of HIF-1 alpha HET wounded tissues were significantly lower compared with WT tissues. S1P treatment of bone marrow macrophages (BMMs) significantly upregulated expression of S1P(1) in WT mice compared with HIF-1 alpha HET. Phosphorylation of MAPK rapidly decreased in BMMs of HIF-1 alpha HET mice than in BMMs of WT mice by S1P stimulation. Moreover, S1P enhanced HIF-1 alpha expression via S1P(1) receptors to affect macrophage migration.

Conclusions
HIF-1 alpha deficiency aggravates M1 and M2 macrophage infiltration and controls macrophage motility via S1P/S1P(1) signaling. These results suggest that HIF-1 alpha signaling may contribute to the regulation of palatal wound healing. en-copyright= kn-copyright= en-aut-name=HutamiIslamy Rahma en-aut-sei=Hutami en-aut-mei=Islamy Rahma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IzawaTakashi en-aut-sei=Izawa en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Khurel‐OchirTsendsuren en-aut-sei=Khurel‐Ochir en-aut-mei=Tsendsuren kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakamakiTakuma en-aut-sei=Sakamaki en-aut-mei=Takuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IwasaAkihiko en-aut-sei=Iwasa en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TomitaShuhei en-aut-sei=Tomita en-aut-mei=Shuhei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TanakaEiji en-aut-sei=Tanaka en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Orthodontics and Dentofacial Orthopedics Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan kn-affil= affil-num=2 en-affil=Department of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Orthodontics and Dentofacial Orthopedics Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan kn-affil= affil-num=4 en-affil=Department of Orthodontics and Dentofacial Orthopedics Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan kn-affil= affil-num=5 en-affil=Department of Orthodontics and Dentofacial Orthopedics Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan kn-affil= affil-num=6 en-affil=Department of Pharmacology Osaka City University Graduate School of Medicine Osaka Japan kn-affil= affil-num=7 en-affil=Department of Orthodontics and Dentofacial Orthopedics Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan kn-affil= en-keyword=HIF-1α kn-keyword=HIF-1α en-keyword=S1P receptor kn-keyword=S1P receptor en-keyword=hypoxia kn-keyword=hypoxia en-keyword=wound healing kn-keyword=wound healing en-keyword=M1/M2 macrophage kn-keyword=M1/M2 macrophage en-keyword=DMOG kn-keyword=DMOG END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue= article-no= start-page=093056 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Superconductivity in a new layered triangular-lattice system Li2IrSi2 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report on the crystal structure and superconducting properties of a novel iridium-silicide, namely Li2IrSi2. It has a Ag2NiO2-type structure (space group R-3m) with the lattice parameters a = 4.028 30(6) ? and c = 13.161 80(15) ?. The crystal structure comprises IrSi2 and double Li layers stacked alternately along the c-axis. The IrSi2 layer includes a two-dimensional Ir equilateral-triangular lattice. Electrical resistivity and static magnetic measurements revealed that Li2IrSi2 is a type-II superconductor with critical temperature (Tc) of 3.3 K. We estimated the following superconducting parameters: lower critical field Hc1(0) ~ 42 Oe, upper critical field Hc2(0) ~ 1.7 kOe, penetration depth λ0 ~ 265 nm, coherence length ξ0 ~ 44 nm, and Ginzburg?Landau parameter κGL ~ 6.02. The specific-heat data suggested that superconductivity in Li2IrSi2 could be attributed to weak-coupling Cooper pairs. en-copyright= kn-copyright= en-aut-name=HoriganeK en-aut-sei=Horigane en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakeuchiK en-aut-sei=Takeuchi en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HyakumuraD en-aut-sei=Hyakumura en-aut-mei=D kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HorieR en-aut-sei=Horie en-aut-mei=R kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SatoT en-aut-sei=Sato en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MuranakaT en-aut-sei=Muranaka en-aut-mei=T kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawashimaK en-aut-sei=Kawashima en-aut-mei=K kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IshiiH en-aut-sei=Ishii en-aut-mei=H kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KubozonoY en-aut-sei=Kubozono en-aut-mei=Y kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OrimoS en-aut-sei=Orimo en-aut-mei=S kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IsobeM en-aut-sei=Isobe en-aut-mei=M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AkimitsuJ en-aut-sei=Akimitsu en-aut-mei=J kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Research Institute for Interdisciplinary Science, Okayama University, kn-affil= affil-num=2 en-affil=Graduate School of natural science and technology, Okayama University kn-affil= affil-num=3 en-affil=Department of Physics and Mathematics, Aoyama Gakuin University kn-affil= affil-num=4 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=5 en-affil=Institute for Materials Research, Tohoku University kn-affil= affil-num=6 en-affil=Department of Engineering Science, University of Electro-Communications kn-affil= affil-num=7 en-affil=Department of Physics and Mathematics, Aoyama Gakuin University kn-affil= affil-num=8 en-affil=National Synchrotron Radiation Research Center kn-affil= affil-num=9 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=10 en-affil=Institute for Materials Research, Tohoku University kn-affil= affil-num=11 en-affil=National Institute for Materials Science (NIMS) kn-affil= affil-num=12 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= en-keyword=supreconductivity kn-keyword=supreconductivity en-keyword=iridium-silicide kn-keyword=iridium-silicide en-keyword=spin?orbit coupling kn-keyword=spin?orbit coupling END start-ver=1.4 cd-journal=joma no-vol=17 cd-vols= no-issue=2 article-no= start-page=202 end-page=209 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20181214 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The novel latex agglutination turbidimetric immunoassay system for simultaneous measurements of calprotectin and hemoglobin in feces en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Aims
Fecal calprotectin (Fcal) as well as the fecal immunochemical test (FIT) are useful biomarkers for detecting activity and mucosal healing in inflammatory bowel diseases. Here, we report the performance of simultaneous measurements of Fcal and FIT for ulcerative colitis (UC) patients using the newly-developed latex agglutination turbidimetric immunoassay (LATIA) system.
Methods
Fcal and hemoglobin were measured by the LATIA system in 152 UC patients who underwent colonoscopy. Fcal was also quantified with a conventional enzyme-linked immunosorbent assay (ELISA). Fecal markers were evaluated in conjunction with the mucosal status of UC, which was assessed via the Mayo endoscopic subscore (MES) classification.
Results
The LATIA system could quantify calprotectin and hemoglobin simultaneously with the same fecal samples within 10 minutes. The values of the Fcal-LATIA closely correlated with those of the Fcal-ELISA (Spearman rank correlation coefficient, r=0.84; P<0.0001). The values of Fcal for each assay and the FIT all significantly correlated with the MESs (Spearman rank correlation coefficient, Fcal-LATIA: r=0.58, Fcal-ELISA: r=0.55, and FIT: r=0.72). The mucosal healing predictability (determined by an MES of 0 alone) of the Fcal-LATIA, Fcal-ELISA, and FIT-LATIA with the cutoffs determined by receiver operating characteristic curve analysis was 0.79, 0.78, and 0.92 for sensitivity, respectively, and 0.78, 0.69, and 0.73 for specificity, respectively.
Conclusions
The performance of the novel Fcal-LATIA was equivalent to that of the conventional Fcal assay. Simultaneous measurements with FITs would promote the clinical relevance of fecal biomarkers in UC. en-copyright= kn-copyright= en-aut-name=HiraokaSakiko en-aut-sei=Hiraoka en-aut-mei=Sakiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakashimaShiho en-aut-sei=Takashima en-aut-mei=Shiho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InokuchiToshihiro en-aut-sei=Inokuchi en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakaraiAsuka en-aut-sei=Nakarai en-aut-mei=Asuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakaharaMasahiro en-aut-sei=Takahara en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HaradaKeita en-aut-sei=Harada en-aut-mei=Keita kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SekiYasuhiro en-aut-sei=Seki en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WatanabeKatsunori en-aut-sei=Watanabe en-aut-mei=Katsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KatoJun en-aut-sei=Kato en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Endoscopy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Biochemical Research Laboratory-I, Eiken Chemical Co., Ltd. kn-affil= affil-num=8 en-affil=Department of Biochemical Research Laboratory-I, Eiken Chemical Co., Ltd. kn-affil= affil-num=9 en-affil=Department of Gastroenterology, Mitsui Memorial Hospital kn-affil= affil-num=10 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Colitis kn-keyword=Colitis en-keyword=ulcerative kn-keyword=ulcerative en-keyword=Fecal calprotectin kn-keyword=Fecal calprotectin en-keyword=Quantitative fecal immunochemical test kn-keyword=Quantitative fecal immunochemical test en-keyword=Latex agglutination turbidimetric immunoassay kn-keyword=Latex agglutination turbidimetric immunoassay en-keyword=Mucosal healing kn-keyword=Mucosal healing END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=2 article-no= start-page=838 end-page=846 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Adsorption enhancement of nitrogen gas by atomically heterogeneous nanospace of boron nitride en-subtitle= kn-subtitle= en-abstract= kn-abstract=In this study, porous boron nitride (p-BN) with hexagonal phase boron nitride (h-BN) pore walls was synthesized using high-temperature calcination. Negligible variation in pore-wall structure can be observed in powder X-ray diffraction (XRD) profiles and infrared (IR) spectra. However, a highly stable p-BN with a stable pore structure even at 973 K under the oxidative conditions is obtained when synthesized at higher than 1573 K under nitrogen gas flow. For p-BN, this stability is obtained by generating h-BN microcrystals. Nitrogen adsorption?desorption isotherms at 77 K provide type-IV features and typical adsorption?desorption hysteresis, which suggests micropore and mesopore formation. Moreover, adsorption?desorption isotherms of Ar at 87 K are measured and compared with those of nitrogen. The relative adsorbed amount of nitrogen (i.e., the amount of nitrogen normalized by that of Ar at each relative pressure or adsorption potential value) on p-BN is considerably larger than that on microporous carbon at low-pressure regions, which suggests the existence of strong adsorption sites on the p-BN surface. In fact, the relative number of adsorbed nitrogen molecules to that of Ar on p-BN is, at most, 150%?200% larger than that on microporous carbon for the same adsorption potential state. Furthermore, additional adsorption enhancement to nitrogen between P/P0 = 10?5 and 10?3 can be observed for p-BN treated at 1673 K, which suggests the uniformly adsorbed layer formation of nitrogen molecules in the vicinity of a basal planar surface. Thus, unlike typical nanoporous sp2 carbons, p-BN materials have the potential to enhance adsorption for certain gas species because of their unique surface state. en-copyright= kn-copyright= en-aut-name=KimuraJun en-aut-sei=Kimura en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OhkuboTakahiro en-aut-sei=Ohkubo en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name= NishinaYuta en-aut-sei= Nishina en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UritaKoki en-aut-sei=Urita en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KurodaYasushige en-aut-sei=Kuroda en-aut-mei=Yasushige kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Research Core for Interdisciplinary Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Engineering, Nagasaki University kn-affil= affil-num=5 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=12 article-no= start-page=e0243382 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20201223 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Shape analysis of rectus extraocular muscles with age and axial length using anterior segment optical coherence tomography en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose
This study aimed to evaluate the shape of the extraocular muscles (EOMs) in normal subjects using the en-face images of anterior segment optical coherence tomography (AS-OCT). The EOM insertion and the direction of the muscle fibers were investigated.
Subjects and methods
A total of 97 healthy normal subjects (194 eyes) at Okayama University Hospital (age, 47.1±21.5 years; range, 8?79 years) participated in the study. A series of 256 tomographic images of the rectus EOMs were captured using the C-scan function of the AS-OCT (CASIA2, TOMEY Co., Japan), and the images were converted to en-face images in multi-TIFF format. The anterior chamber angle to EOM insertion distance (AID) and the angle of the muscle fibers from the insertion site (angle of muscles) were measured from the images. The correlations of AID and angle of muscles with age and axial length were investigated and evaluated.
Results
AID and angle of muscles were significantly correlated with age or axial length in some EOMs. The AIDs of medial rectus (MR) (P = 0.000) and superior rectus (SR) (P = 0.005) shortened with age. The AIDs of MR (P = 0.001) and inferior rectus (IR) (P = 0.035) elongated with axial length, whereas lateral rectus (LR) (P = 0.013) shortened. The angles of MR (P = 0.001) and LR (P = 0.000) were found to have a more downward direction toward the posterior in older subjects.
Conclusion
En-face images can be created by AS-OCT, and the shape of the EOMs in normal subjects using these image measurements was available. With the ability to assess the EOMs, AID and angle of muscles are expected give useful information for treating and diagnosing strabismus-related diseases. en-copyright= kn-copyright= en-aut-name=ShibataKiyo en-aut-sei=Shibata en-aut-mei=Kiyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiwaraAtsushi en-aut-sei=Fujiwara en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamasakiIchiro en-aut-sei=Hamasaki en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShimizuTakehiro en-aut-sei=Shimizu en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KonoReika en-aut-sei=Kono en-aut-mei=Reika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KanenagaKeisuke en-aut-sei=Kanenaga en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakazawaMasanori en-aut-sei=Nakazawa en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MorizaneYuki en-aut-sei=Morizane en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Orthoptics, Faculty of Rehabilitation, Kawasaki University of Medical Welfare kn-affil= affil-num=3 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences kn-affil= affil-num=8 en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=1 article-no= start-page=e501 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200413 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Therapeutic strategies for ischemia reperfusion injury in emergency medicine en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ischemia reperfusion (IR) injury occurs when blood supply, perfusion, and concomitant reoxygenation is restored to an organ or area following an initial poor blood supply after a critical time period. Ischemia reperfusion injury contributes to mortality and morbidity in many pathological conditions in emergency medicine clinical practice, including trauma, ischemic stroke, myocardial infarction, and post-cardiac arrest syndrome. The process of IR is multifactorial, and its pathogenesis involves several mechanisms. Reactive oxygen species are considered key molecules in reperfusion injury due to their potent oxidizing and reducing effects that directly damage cellular membranes by lipid peroxidation. In general, IR injury to an individual organ causes various pro-inflammatory mediators to be released, which could then induce inflammation in remote organs, thereby possibly advancing the dysfunction of multiple organs. In this review, we summarize IR injury in emergency medicine. Potential therapies include pharmacological treatment, ischemic preconditioning, and the use of medical gases or vitamin therapy, which could significantly help experts develop strategies to inhibit IR injury. en-copyright= kn-copyright= en-aut-name=NaitouHiromichi en-aut-sei=Naitou en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NojimaTsuyoshi en-aut-sei=Nojima en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujisakiNoritomo en-aut-sei=Fujisaki en-aut-mei=Noritomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsukaharaKohei en-aut-sei=Tsukahara en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamamotoHirotsugu en-aut-sei=Yamamoto en-aut-mei=Hirotsugu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamadaTaihei en-aut-sei=Yamada en-aut-mei=Taihei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AokageToshiyuki en-aut-sei=Aokage en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YumotoTetsuya en-aut-sei=Yumoto en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OsakoTakaaki en-aut-sei=Osako en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Emergency, Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Emergency medicine kn-keyword=Emergency medicine en-keyword=inflammation kn-keyword=inflammation en-keyword=ischemia reperfusion kn-keyword=ischemia reperfusion en-keyword=remote ischemic preconditioning kn-keyword=remote ischemic preconditioning en-keyword=shock kn-keyword=shock en-keyword=therapeutic hypothermia kn-keyword=therapeutic hypothermia END start-ver=1.4 cd-journal=joma no-vol=228 cd-vols= no-issue= article-no= start-page=102712 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202011 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Orexin A and B in the rat superior salivatory nucleus en-subtitle= kn-subtitle= en-abstract= kn-abstract=Orexin (OX), which regulates sleep and wakefulness and feeding behaviors has 2 isoforms, orexin-A and -B (OXA and OXB). In this study, the distribution of OXA and OXB was examined in the rat superior salivatory nucleus (SSN) using retrograde tracing and immunohistochemical and methods. OXA- and OXB-immunoreactive (-ir) nerve fibers were seen throughout the SSN. These nerve fibers surrounded SSN neurons retrogradely labeled with Fast blue (FB) from the corda-lingual nerve. FB-positive neurons had pericellular OXA- (47.5%) and OXB-ir (49.0%) nerve fibers. Immunohistochemistry for OX receptors also demonstrated the presence of OX1R and OX2R in FB-positive SSN neurons. The majority of FB-positive SSN neurons contained OX1R- (69.7%) or OX2R-immunoreactivity (57.8%). These neurons had small and medium-sized cell bodies. In addition, half of FB-positive SSN neurons which were immunoreactive for OX1R (47.0%) and OX2R (52.2%) had pericellular OXA- and OXB-ir nerve fibers, respectively. Co-expression of OX1R- and OX2R was common in FB-positive SSN neurons. The present study suggests a possibility that OXs regulate the activity of SSN neurons through OX receptors. en-copyright= kn-copyright= en-aut-name=SatoTadasu en-aut-sei=Sato en-aut-mei=Tadasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YajimaTakehiro en-aut-sei=Yajima en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujitaMasako en-aut-sei=Fujita en-aut-mei=Masako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KobashiMotoi en-aut-sei=Kobashi en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IchikawaHiroyuki en-aut-sei=Ichikawa en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YoshidaRyusuke en-aut-sei=Yoshida en-aut-mei=Ryusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MitohYoshihiro en-aut-sei=Mitoh en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry kn-affil= affil-num=2 en-affil=Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry kn-affil= affil-num=3 en-affil=Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry kn-affil= affil-num=6 en-affil=Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Orexin kn-keyword=Orexin en-keyword=Orexin receptor kn-keyword=Orexin receptor en-keyword=Superior salivatory nucleus kn-keyword=Superior salivatory nucleus en-keyword=Preganglionic neuron kn-keyword=Preganglionic neuron en-keyword=Chorda-lingual nerve kn-keyword=Chorda-lingual nerve en-keyword=Immunohistochemistry kn-keyword=Immunohistochemistry END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=5 article-no= start-page=415 end-page=422 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Oblique Surface Dose Calculation in High-Energy X-ray Therapy en-subtitle= kn-subtitle= en-abstract= kn-abstract=During radiation therapy, incident radiation oblique to the skin surface is high and may cause severe skin damage. Understanding the dose of radiation absorbed by the skin is important for predicting skin damage due to radiation. In this study, we used a high-energy (4 MV) X-ray system and an optically stimulated luminescence dosimeter (OSLD) that was developed for personal exposure dosimetry. We determined the dose variation and angular dependence, which are the characteristics of a small OSLD required to derive the calculation formula for the oblique surface dose. The dose variation was determined using the coefficient of variation. The maximum coefficient of variation for 66 small-field OSLDs was 1.71%. The angular dependence, obtained from the dose ratio of the dosimeter in the vertical direction, had a maximum value of 1.37. We derived a new equation in which the oblique surface dose can be calculated within the error range of ?7.7-5.1%. en-copyright= kn-copyright= en-aut-name=NarihiroNaomasa en-aut-sei=Narihiro en-aut-mei=Naomasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OitaMasataka en-aut-sei=Oita en-aut-mei=Masataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakedaYoshihiro en-aut-sei=Takeda en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Department of Radiological Technology, Okayama University kn-affil= affil-num=2 en-affil=Department of Graduate School of Interdisciplinary Sciences and Engineering in Health Systems, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Health Sciences, Department of Radiological Technology, Okayama University kn-affil= en-keyword=optically stimulated luminescent dosimeter kn-keyword=optically stimulated luminescent dosimeter en-keyword=radiotherapy kn-keyword=radiotherapy en-keyword=oblique surface dose kn-keyword=oblique surface dose en-keyword=high-energy X-ray therapy kn-keyword=high-energy X-ray therapy en-keyword=angular dependence kn-keyword=angular dependence END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=5 article-no= start-page=407 end-page=413 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202010 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comprehensive Prospective Analysis of the Factors Contributing to Aspiration Pneumonia Following Endoscopic Submucosal Dissection in Patients with Early Gastric Neoplasms en-subtitle= kn-subtitle= en-abstract= kn-abstract=Endoscopic submucosal dissection (ESD) has become the first-line treatment for early gastric neoplasms; however, a subset of patients treated by this method develop aspiration pneumonia. We conducted a comprehensive prospective analysis of the factors contributing to post-ESD aspiration pneumonia in early gastric neoplasms in this study, with special focus on whether pre-treatment oral care can prevent aspiration pneumonia. Sixty-one patients who underwent ESD for gastric neoplasms were randomly assigned to the oral care or control groups. ESD was performed under deep sedation. Of 60 patients whose data were available for analysis, 5 (8.3%) experienced pneumonia confirmed either by chest radiography or computed tomography. Although no difference in the rate of pneumonia was found between the control and oral care groups, the post-oral care bacteria count was significantly higher in the saliva of patients who developed pneumonia compared to those without pneumonia. In addition, the presence of vascular brain diseases and the dose of meperidine were also significantly associated with the occurrence of pneumonia. These results suggest that the number of oral bacteria as well as pre-existing vascular brain diseases and high-dose narcotics can affect the incidence of post-ESD pneumonia. en-copyright= kn-copyright= en-aut-name=TogoMasaaki en-aut-sei=Togo en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AkazawaYuko en-aut-sei=Akazawa en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=AkashiTaro en-aut-sei=Akashi en-aut-mei=Taro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamashitaRika en-aut-sei=Yamashita en-aut-mei=Rika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YoshitomiIzumi en-aut-sei=Yoshitomi en-aut-mei=Izumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OhbaKazuo en-aut-sei=Ohba en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HashimotoSatsuki en-aut-sei=Hashimoto en-aut-mei=Satsuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IwashitaHiroko en-aut-sei=Iwashita en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KurogiTadafumi en-aut-sei=Kurogi en-aut-mei=Tadafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OsadaYukiko en-aut-sei=Osada en-aut-mei=Yukiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=WadaNoriko en-aut-sei=Wada en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=ImamuraYoshifumi en-aut-sei=Imamura en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=HashiguchiKeiichi en-aut-sei=Hashiguchi en-aut-mei=Keiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamaguchiNaoyuki en-aut-sei=Yamaguchi en-aut-mei=Naoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KondoHisayoshi en-aut-sei=Kondo en-aut-mei=Hisayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=NakaoKazuhiko en-aut-sei=Nakao en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences kn-affil= affil-num=4 en-affil=Oral Care Center, Nagasaki University Hospital kn-affil= affil-num=5 en-affil=JCHO Isahaya General Hospital kn-affil= affil-num=6 en-affil=JCHO Isahaya General Hospital kn-affil= affil-num=7 en-affil=JCHO Isahaya General Hospital kn-affil= affil-num=8 en-affil=JCHO Isahaya General Hospital kn-affil= affil-num=9 en-affil=Oral Care Center, Nagasaki University Hospital kn-affil= affil-num=10 en-affil=Dental Hygienist's Office, Department of Medical Technology, Nagasaki University Hospital kn-affil= affil-num=11 en-affil=Dental Hygienist's Office, Department of Medical Technology, Nagasaki University Hospital kn-affil= affil-num=12 en-affil=Department of Respiratory Medicine, Nagasaki University Hospital kn-affil= affil-num=13 en-affil=Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences kn-affil= affil-num=14 en-affil=Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences kn-affil= affil-num=15 en-affil=Biostatistics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Medicine kn-affil= affil-num=16 en-affil=Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences kn-affil= en-keyword=endoscopy kn-keyword=endoscopy en-keyword=oral bacteria kn-keyword=oral bacteria en-keyword=respiratory disease kn-keyword=respiratory disease en-keyword=pneumonia kn-keyword=pneumonia en-keyword=sedation kn-keyword=sedation END start-ver=1.4 cd-journal=joma no-vol=179 cd-vols= no-issue= article-no= start-page=114401 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A specific formation of an iridium(III) hydrido complex bearing 8-(diphenylphosphino)quinoline en-subtitle= kn-subtitle= en-abstract= kn-abstract=A reaction of [Cp*IrCl(Ph2Pqn)]PF6 {Cp* = η5-pentamethylcyclopentadienyl; Ph2Pqn = 8-(diphenylphosphino)quinoline} and Ag(CF3SO3) in methanol afforded orange crystals of the corresponding hydrido complex, [Cp*IrH(Ph2Pqn)]PF6, which was identified by 1H, 31P{1H} NMR and IR spectroscopy as well as X-ray structural analysis. The reactions in deuterated solvents indicated that formation of the hydrido complex proceeded via β-hydrogen elimination of the coordinated methanol molecule. It was also revealed that the hydrido formation was specific for the complex bearing Ph2Pqn ancillary ligand; the analogous complex with 1,2-bis(diphenylphosphino)benzene (diphos) or 1,10-phenanthroline (phen) did not give the corresponding hydrido complex by a similar reaction with Ag+ in methanol. In order to elucidate the reason for the different reactivity among these complexes, the crystal structures of the precursor chlorido complexes, [Cp*IrCl(Ph2Pqn)]PF6, [Cp*IrCl(diphos)]PF6 and [Cp*IrCl(phen)]PF6, as well as an acetonitrile complex of [Cp*Ir(Ph2Pqn)(CH3CN)](PF6)2, were also determined by X-ray analysis. The resulting structural information suggested that a specific formation of the hydrido complex with Ph2Pqn could be originated from the facile formation of the corresponding methanol complex and the hemilabile nature of ancillary Ph2Pqn ligand, which induced the reactivity of the coordinated methanol toward β-hydrogen elimination. en-copyright= kn-copyright= en-aut-name=AriyoshiKeita en-aut-sei=Ariyoshi en-aut-mei=Keita kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KoteraMai en-aut-sei=Kotera en-aut-mei=Mai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NamiokaAtsushi en-aut-sei=Namioka en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SuzukiTakayoshi en-aut-sei=Suzuki en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=2 en-affil=Department of Chemistry, Faculty of Science, Osaka University kn-affil= affil-num=3 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= en-keyword=8-Quinolylphosphine kn-keyword=8-Quinolylphosphine en-keyword=Hydrido complex kn-keyword=Hydrido complex en-keyword=Ancillary ligand effect kn-keyword=Ancillary ligand effect en-keyword=β-Hydrogen elimination kn-keyword=β-Hydrogen elimination en-keyword=Methanol complex kn-keyword=Methanol complex END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=2 article-no= start-page=123 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract= The aim of this study was to evaluate the ability of pretreatment 90-min 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment 18F-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p<0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment 18F-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly. en-copyright= kn-copyright= en-aut-name=FukuharaRyuichiro en-aut-sei=Fukuhara en-aut-mei=Ryuichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShinyaTakayoshi en-aut-sei=Shinya en-aut-mei=Takayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukumaShogo en-aut-sei=Fukuma en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OgawaNanako en-aut-sei=Ogawa en-aut-mei=Nanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MasaokaYoshihisa en-aut-sei=Masaoka en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MarunakaHidenori en-aut-sei=Marunaka en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=AriokaTadashi en-aut-sei=Arioka en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HirakiTakao en-aut-sei=Hiraki en-aut-mei=Takao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KajiMitsumasa en-aut-sei=Kaji en-aut-mei=Mitsumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KanazawaSusumu en-aut-sei=Kanazawa en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=3 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=4 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=5 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=6 en-affil=Department of Pathology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=7 en-affil=Department of Otolaryngology-Head & Neck Surgery, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=8 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=9 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=10 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= affil-num=11 en-affil=Department of Radiology, Okayama Diagnostic Imaging Center, Okayama university Hospital kn-affil= en-keyword=18F-fluorodeoxyglucose positron emission tomography/computed tomography kn-keyword=18F-fluorodeoxyglucose positron emission tomography/computed tomography en-keyword=extranodular spread kn-keyword=extranodular spread en-keyword=metastasis kn-keyword=metastasis en-keyword=oral squamous cell carcinoma kn-keyword=oral squamous cell carcinoma END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=13 article-no= start-page=2495 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND/AIM:Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers.
METHODS:The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model.
RESULTS:A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 ?g/mL, respectively.
CONCLUSION:Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet. en-copyright= kn-copyright= en-aut-name=ZahraMaram Hussein en-aut-sei=Zahra en-aut-mei=Maram Hussein kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SalemTarek A. R. en-aut-sei=Salem en-aut-mei=Tarek A. R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=El-AaragBishoy en-aut-sei=El-Aarag en-aut-mei=Bishoy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YosriNermeen en-aut-sei=Yosri en-aut-mei=Nermeen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=EL-GhlbanSamah en-aut-sei=EL-Ghlban en-aut-mei=Samah kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ZakiKholoud en-aut-sei=Zaki en-aut-mei=Kholoud kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MareiAmel H. en-aut-sei=Marei en-aut-mei=Amel H. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=Abd El-WahedAida en-aut-sei=Abd El-Wahed en-aut-mei=Aida kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SaeedAamer en-aut-sei=Saeed en-aut-mei=Aamer kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KhatibAlfi en-aut-sei=Khatib en-aut-mei=Alfi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AlAjmiMohamed F. en-aut-sei=AlAjmi en-aut-mei=Mohamed F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=ShathiliAbdulrahman M. en-aut-sei=Shathili en-aut-mei=Abdulrahman M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=XiaoJianbo en-aut-sei=Xiao en-aut-mei=Jianbo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KhalifaShaden A. M. en-aut-sei=Khalifa en-aut-mei=Shaden A. M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=El-SeediHesham R. en-aut-sei=El-Seedi en-aut-mei=Hesham R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Department of Biochemistry, College of Medicine, Qassim University kn-affil= affil-num=3 en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Department of Chemistry, Faculty of Science, Menoufia University kn-affil= affil-num=5 en-affil=Biochemistry Division, Chemistry Department, Faculty of Science, Menoufia University kn-affil= affil-num=6 en-affil=Department of Chemistry, Faculty of Science, Menoufia University kn-affil= affil-num=7 en-affil=Department of Chemistry, Faculty of Science, Menoufia University kn-affil= affil-num=8 en-affil=Department of Chemistry, Faculty of Science, Menoufia University kn-affil= affil-num=9 en-affil=Department of Chemistry, Quaid-i-Azam University kn-affil= affil-num=10 en-affil=Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia kn-affil= affil-num=11 en-affil=Pharmacognosy Group, College of Pharmacy, King Saud University kn-affil= affil-num=12 en-affil=Al-Rayan Research and Innovation Center, Al-Rayan Colleges kn-affil= affil-num=13 en-affil=Institute of Chinese Medical Sciences, University of Macau kn-affil= affil-num=14 en-affil=Clinical Research Centre, Karolinska University Hospital kn-affil= affil-num=15 en-affil=Department of Chemistry, Faculty of Science, Menoufia University kn-affil= en-keyword=Alpinia zerumbet kn-keyword=Alpinia zerumbet en-keyword=5,6-dehydrokawain kn-keyword=5,6-dehydrokawain en-keyword=Ehrlich ascites carcinoma kn-keyword=Ehrlich ascites carcinoma en-keyword=anti-tumor kn-keyword=anti-tumor en-keyword=anti-oxidant kn-keyword=anti-oxidant END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=18 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190911 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=The current study aimed to synthesize new metal coordination complexes with potential biomedical applications. Metal complexes were prepared via the reaction of isatin-N(4)anti- pyrinethiosemicarbazone ligand 1 with Cu(II), Ni(II), Co(II), Zn(II), and Fe(III) ions. The obtained metal complexes 2?12 were characterized using elemental, spectral (1H-NMR, EPR, Mass, IR, UV-Vis) and thermal (TGA) techniques, as well as magnetic moment and molar conductance measurements. In addition, their geometries were studied using EPR and UV?Vis spectroscopy. To evaluate the in vivo anti-cancer activities of these complexes, the ligand 1 and its metal complexes 2, 7 and 9 were tested against solid tumors. The solid tumors were induced by subcutaneous (SC) injection of Ehrlich ascites carcinoma (EAC) cells in mice. The impact of the selected complexes on the reduction of tumor volume was determined. Also, the expression levels of vascular endothelial growth factor (VEGF) and cysteine aspartyl-specific protease-7 (caspase-7) in tumor and liver tissues of mice bearing EAC tumor were determined. Moreover, their effects on alanine transaminase (ALT), aspartate transaminase (AST), albumin, and glucose levels were measured. The results revealed that the tested compounds, especially complex 9, reduced tumor volume, inhibited the expression of VEGF, and induced the expression of caspase-7. Additionally, they restored the levels of ALT, AST, albumin, and glucose close to their normal levels. Taken together, our newly synthesized metal complexes are promising anti-cancer agents against solid tumors induced by EAC cells as supported by the inhibition of VEGF and induction of caspase-7. en-copyright= kn-copyright= en-aut-name=El-SaiedFathy en-aut-sei=El-Saied en-aut-mei=Fathy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=El-AaragBishoy en-aut-sei=El-Aarag en-aut-mei=Bishoy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SalemTarek en-aut-sei=Salem en-aut-mei=Tarek kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SaidGhada en-aut-sei=Said en-aut-mei=Ghada kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KhalifaShaden A. M. en-aut-sei=Khalifa en-aut-mei=Shaden A. M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=El-SeediHesham R. en-aut-sei=El-Seedi en-aut-mei=Hesham R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Chemistry, Faculty of Science, Menoufia University kn-affil= affil-num=2 en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Department of Molecular Biology, Genetic Engineering & Biotechnology Institute, University of Sadat City kn-affil= affil-num=4 en-affil=Department of Chemistry, Faculty of Science, Menoufia University kn-affil= affil-num=5 en-affil=Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University kn-affil= affil-num=6 en-affil=Department of Chemistry, Faculty of Science, Menoufia University kn-affil= en-keyword=metal complexes kn-keyword=metal complexes en-keyword=isatin-N(4)antipyrinethiosemicarbazone kn-keyword=isatin-N(4)antipyrinethiosemicarbazone en-keyword=Ehrlich ascites carcinoma kn-keyword=Ehrlich ascites carcinoma en-keyword=tumor volume kn-keyword=tumor volume en-keyword=VEGF kn-keyword=VEGF en-keyword=caspase-7 kn-keyword=caspase-7 END start-ver=1.4 cd-journal=joma no-vol=74 cd-vols= no-issue=1 article-no= start-page=49 end-page=52 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Alcohol Consumption or Excessive Use of Psychotropic Medication Prior to Suicidal Self-injury in Patients with Adjustment Disorder, Depression, and Schizophrenia: A Cross-sectional Study en-subtitle= kn-subtitle= en-abstract= kn-abstract= The use of alcohol or drug(s) prior to self-injury is a possible inducing factor for suicidal self-injuries among patients with adjustment disorder. We analyzed the cases of 175 individuals who were admitted to the intensive care unit (ICU) of Tokyo Medical and Dental University Medical Hospital for suicidal self-injury to determine whether alcohol consumption or an excessive use of prescribed psychotropic medications prior to self-injury is more common in patients with adjustment disorder. During a 7-year period (July 2006 to June 2013) following their deliberate self-injuries, 971 patients were admitted to the ICU. Our study sample (n=175) was restricted to patients with adjustment disorder (n=48), major depressive disorder (n=90), or schizophrenia (n=37). The outcome variable was alcohol consumption or excessive use of medications prior to suicidal self-injury. A logistic regression analysis revealed that the patients with adjustment disorder more commonly showed alcohol consumption or excessive medication use prior to their suicidal self-injury compared to those with schizophrenia (odds ratio: 8.10; 95%CI: 2.97-24.60). To inhibit suicidal self-injury among patients with adjustment disorder, it is important to continue efforts to provide psychoeducation about alcohol use and to instruct the patients to take their prescribed medication(s) only as directed by their physician. en-copyright= kn-copyright= en-aut-name=TakeuchiTakashi en-aut-sei=Takeuchi en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkumuraYasuyuki en-aut-sei=Okumura en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IchikuraKanako en-aut-sei=Ichikura en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Section of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University kn-affil= affil-num=2 en-affil=Mental Health Promotion Project, Tokyo Metropolitan Institute of Medical Science, kn-affil= affil-num=3 en-affil=Department of Health Science, School of Allied Health Sciences, Kitasato University kn-affil= en-keyword=alcohol kn-keyword=alcohol en-keyword=psychotropic medications kn-keyword=psychotropic medications en-keyword=self-injury kn-keyword=self-injury en-keyword=adjustment disorder kn-keyword=adjustment disorder END start-ver=1.4 cd-journal=joma no-vol=109 cd-vols= no-issue= article-no= start-page=41 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Genetic mechanism for soil-surface roots originating from a New Plant Type rice (Oryza sativa L.) kn-title=イネ地表根に関する遺伝的機構の解明 en-subtitle= kn-subtitle= en-abstract= kn-abstract= A new method of using seedling trays to evaluate root angle distribution in rice (Oryza sativa. L) was developed. By using this method, the root angle distributions of 97 accessions were characterized into two cluster groups ; A and B. The numbers of accessions in group A were limited, and these were categorized as shallow rooting types including soil-surface root. Group B included from shallow to deep rooting types, including both Indica and Japonica Group cultivars, lowland and upland cultivars, and landraces and improved types. An introgression line YTH16 harboring chromosome segments from a New Plant Type cultivar IR65600-87-2-2-3 with genetic background of an Indica Group rice IR 64, was included in Group A. To clarify the genetic mechanism for soil-surface rooting, quantitative trait loci (QTL) analysis was performed using hybrid populations derived from a cross between IR 64 and YTH16. A total of 8 QTLs were detected in the 3 introgressed segments on chromosomes (chr.) 2, 5 and 7. Seven chromosome segment lines (CSLs) combining these 3 QTL regions were selected from the progenies. The 2 CSLs harboring a single region (excluding the CSL with a region on chr. 5) showed high soil-surface root scores and low root vertical angles (RVA) in comparison with IR 64. Four CSLs harboring 2 or 3 regions showed high scores and low RVAs in comparison with YTH16 and the CSLs harboring a single QTL region. These results indicated that the soil-surface and shallow rooting of YTH16 was controlled by the 2 major QTLs’ regions on chrs. 2 and 7, and that chr. 5 particularly played a role for supporting the effect with them. en-copyright= kn-copyright= en-aut-name=TomitaAsami en-aut-sei=Tomita en-aut-mei=Asami kn-aut-name=冨田朝美 kn-aut-sei=冨田 kn-aut-mei=朝美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 環境生命科学研究科 en-keyword=root angle distribution kn-keyword=root angle distribution en-keyword=soil-surface root kn-keyword=soil-surface root en-keyword=New Plant Type kn-keyword=New Plant Type en-keyword=QTL kn-keyword=QTL en-keyword=rice (Oryza sativa L.) kn-keyword=rice (Oryza sativa L.) END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=1 article-no= start-page=90 end-page=100 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190211 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Accelerated induction of in vitro apatite formation by parallel alignment of hydrothermally oxidized titanium substrates separated by sub-millimeter gaps en-subtitle= kn-subtitle= en-abstract= kn-abstract= Although autoclaving is a common sterilization method for biomedical devices, the ability to induce deposition of apatite particles on hydrothermally treated titanium is still not fully realized. This is because the induction ability is too weak to be evaluated via in vitro apatite formation in Kokubo's simulated body fluid (SBF) by the conventional immersion method, i.e. using samples with open and smooth surface. This study reports on the surface structure of hydrothermally treated titanium and the ability to induce deposition of apatite particles on the surface of parallel confined spaces separated by sub-millimeter gaps in Kokubo's SBF. Thin-film X-ray diffraction and analyses using Fourier transform infra-red (FT-IR) spectroscopy and Raman spectroscopy revealed that a nano-crystalline anatase-type titanium oxide layer was formed on titanium substrates after hydrothermal treatment at 150 degrees C for 2 h. When growth of the titanium oxide layer was moderately suppressed, the hydrothermally treated titanium surface exhibited a characteristic interference color, silver or gold, which does not impair the esthetic appearance of the titanium-based implant. The ability to induce deposition of apatite particles on hydrothermally treated titanium was remarkably amplified by parallel alignment of substrates separated by sub-millimeter gaps. en-copyright= kn-copyright= en-aut-name=HayakawaSatoshi en-aut-sei=Hayakawa en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkamotoKeigo en-aut-sei=Okamoto en-aut-mei=Keigo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshiokaTomohiko en-aut-sei=Yoshioka en-aut-mei=Tomohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Biomaterials Laboratory, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= en-keyword=Titanium substrate kn-keyword=Titanium substrate en-keyword=apatite deposition kn-keyword=apatite deposition en-keyword=simulated body fluid kn-keyword=simulated body fluid en-keyword=parallel alignment kn-keyword=parallel alignment en-keyword=titania layer kn-keyword=titania layer END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=5 article-no= start-page=403 end-page=411 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Risk Factors for Low Bone Mineral Density Determined in Patients in a General Practice Setting en-subtitle= kn-subtitle= en-abstract= kn-abstract= Osteoporosis increases the risk of bone fractures. It is diagnosed based on an individual’s bone mineral density (BMD) or a fracture without trauma. BMD is usually measured by the dual energy X-ray absorptiometry (DXA) method. Here we investigated factors for the earliest possible prediction of decreased BMD by examining the relationships between patients’ BMD values and changes in the patients’ physical and laboratory values. We retrospectively reviewed the medical records of 149 patients who visited our department in 2014-2015 for a variety of reasons and underwent an area BMD examination by DXA. We analyzed the relationships between decreasing BMD and the patients’ gender, age, body mass index (BMI), medical background, hemoglobin, electrolytes, and thyroid function. Thirty-nine of the patients were diagnosed with osteoporosis based on their T-scores. An adjusted analysis showed that female gender, aging, and increased serum calcium level were significantly related to decreasing femoral BMD, whereas high BMI was associated with an increase in femoral BMD. Collectively the results indicate that for the early detection of low BMD, it is important for general-practice physicians to consider conducting a BMD checkup when treating female and elderly patients with a low BMI and/or elevated serum calcium level. en-copyright= kn-copyright= en-aut-name=AndoAkemi en-aut-sei=Ando en-aut-mei=Akemi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=Honda Mitsugi en-aut-sei=Honda en-aut-mei= Mitsugi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HanayamaYoshihisa en-aut-sei=Hanayama en-aut-mei=Yoshihisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HasegawaKou en-aut-sei=Hasegawa en-aut-mei=Kou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KataokaHitomi en-aut-sei=Kataoka en-aut-mei=Hitomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OtsukaFumio en-aut-sei=Otsuka en-aut-mei=Fumio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=3 en-affil=Division of Radiology, Department of Medical Technology, Okayama University Hospital kn-affil= affil-num=4 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=bone mineral density (BMD) kn-keyword=bone mineral density (BMD) en-keyword=body mass index (BMI) kn-keyword=body mass index (BMI) en-keyword=female gender kn-keyword=female gender en-keyword=hypercalcemia kn-keyword=hypercalcemia en-keyword=osteoporosis kn-keyword=osteoporosis END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=4 article-no= start-page=611 end-page=633 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Method to Suppress Isobaric and Polyatomic Interferences for Measurements of Highly Siderophile Elements in Desilicified Geological Samples en-subtitle= kn-subtitle= en-abstract= kn-abstract= Sample decomposition using inverse aqua regia at elevated temperatures and pressures (e.g., Carius tube or high‐pressure asher) is the most common method used to extract highly siderophile elements (HSEs: Ru, Rh, Pd, Re, Os, Ir, Pt and Au) from geological samples. Recently, it has been recognised that additional HF desilicification is necessary to better recover HSEs, potentially contained within silicate or oxide minerals in mafic samples, which cannot be dissolved solely by inverse aqua regia. However, the abundance of interfering elements tends to increase in the eluent when conventional ion‐exchange purification procedures are applied to desilicified samples. In this study, we developed an improved purification method to determine HSEs in desilicified samples. This method enables the reduction of the ratios of isobaric and polyatomic interferences, relative to the measured intensities of HSE isotope masses, to less than a few hundred parts per million. Furthermore, the total procedural blanks are either comparable to or lower than conventional methods. Thus, this method allows accurate and precise HSE measurements in mafic and ultramafic geological samples, without the need for interference corrections. Moreover, the problem of increased interfering elements, such as Zr for Pd and Cr for Ru, is circumvented for the desilicified samples. en-copyright= kn-copyright= en-aut-name=ZhouXiaoyu en-aut-sei=Zhou en-aut-mei=Xiaoyu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaRyoji en-aut-sei=Tanaka en-aut-mei=Ryoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamanakaMasahiro en-aut-sei=Yamanaka en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakaguchiChie en-aut-sei=Sakaguchi en-aut-mei=Chie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakamuraEizo en-aut-sei=Nakamura en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=2 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=3 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=4 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= affil-num=5 en-affil=The Pheasant Memorial Laboratory for Geochemistry and Cosmochemistry, Institute for Planetary Materials, Okayama University kn-affil= en-keyword=highly siderophile elements kn-keyword=highly siderophile elements en-keyword=desilicification kn-keyword=desilicification en-keyword=isotope dilution method kn-keyword=isotope dilution method en-keyword=high resolution ICP-MS kn-keyword=high resolution ICP-MS en-keyword=N-TIMS kn-keyword=N-TIMS END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1 article-no= start-page=21 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clitoral Blood Flow Changes after Surgery with Tension-Free Vaginal Mesh for Pelvic Organ Prolapse en-subtitle= kn-subtitle= en-abstract= kn-abstract= We measured basal clitoral blood flow by Doppler sonography to determine whether tension-free vaginal mesh(TVM) affects the clitoral blood flow and sexual function in women with pelvic organ prolapse (POP). We performed a prospective study of 22 patients who underwent TVM for POP. Clitoral blood flow was measured by Doppler ultrasound. The resistance index (RI), pulsatility index (PI), peak systolic velocity (PSV), and end-diastolic velocity (EDV) of the clitoral arteries were measured preoperatively and at 1, 3, and 6 months postoperatively. Female sexual function was also investigated with the Female Sexual Function Index (FSFI). The mean PI and RI were increased at 1 month and significantly decreased at 6 months postoperatively (p<0.05). In contrast, the mean PSV and EDV decreased at 1 month postoperatively and increased at 6 months postoperatively. These four parameters recovered to baseline levels at 6 months following surgery. Total FSFI scores improved significantly from 10.2±7.9 at baseline to 18.2±8.9 at 6 months postoperatively. Color Doppler ultrasonography is potentially useful in measuring clitoral blood flow in patients treated with TVM for POP. Prospective long-term studies are needed to evaluate the utility of this modality as a diagnostic and prognostic tool for female sexual dysfunction. en-copyright= kn-copyright= en-aut-name=OiwaYuko en-aut-sei=Oiwa en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WatanabeToyohiko en-aut-sei=Watanabe en-aut-mei=Toyohiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IshiiAyano en-aut-sei=Ishii en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakoTomoko en-aut-sei=Sako en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=InoueMiyabi en-aut-sei=Inoue en-aut-mei=Miyabi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WadaKoichiro en-aut-sei=Wada en-aut-mei=Koichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KobayashiYasuyuki en-aut-sei=Kobayashi en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NasuYasutomo en-aut-sei=Nasu en-aut-mei=Yasutomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Integrated Support Center for Patients and Self-learning, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Miyabi Urogyne Clinic kn-affil= affil-num=7 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=clitoris kn-keyword=clitoris en-keyword=pelvic organ prolapse kn-keyword=pelvic organ prolapse en-keyword=Doppler ultrasound kn-keyword=Doppler ultrasound END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue= article-no= start-page=064425 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Magnetic phase diagram of Sr2-xLaxIrO4 synthesized by mechanical alloying en-subtitle= kn-subtitle= en-abstract= kn-abstract= We report the crystal structure and physical properties of Sr2-xLaxIrO4 synthesized by mechanical alloying. The magnetic transition temperature T-N and electrical resistivity decreased with increasing La doping, consistent with previous studies involving single-crystalline samples. We also identified the relationship between T-N and tetragonal distortion (c/a) in this system. This result suggests that the magnetism of the Sr214 system is strongly correlated with its crystal structure. Zero-field muon spin rotation/relaxation studies revealed that short-range antiferromagnetic ordering is realized in Sr1.9La0.1IrO4; also, the spin-glass state is stabilized in the low-temperature region. The Ir moment estimated from the longitudinal field mu SR results is 0.045 mu(B), ten times smaller than that of Sr2IrO4 (similar to 0.4 mu(B)), indicating that electrons are introduced into the Ir atoms. en-copyright= kn-copyright= en-aut-name=HoriganeKazumasa en-aut-sei=Horigane en-aut-mei=Kazumasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiiM. en-aut-sei=Fujii en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkabeH. en-aut-sei=Okabe en-aut-mei=H. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KobayashiK. en-aut-sei=Kobayashi en-aut-mei=K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HorieR. en-aut-sei=Horie en-aut-mei=R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshiiH. en-aut-sei=Ishii en-aut-mei=H. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=LiaoY. F. en-aut-sei=Liao en-aut-mei=Y. F. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KubozonoY. en-aut-sei=Kubozono en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KodaA. en-aut-sei=Koda en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KadonoR. en-aut-sei=Kadono en-aut-mei=R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AkimitsuJ. en-aut-sei=Akimitsu en-aut-mei=J. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Institute of Materials Structure Science/J-PARC Center, KEK kn-affil= affil-num=4 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil= kn-affil= affil-num=7 en-affil=National Synchrotron Radiation Research Center kn-affil= affil-num=8 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=9 en-affil=Institute of Materials Structure Science/J-PARC Center, KEK kn-affil= affil-num=10 en-affil=Institute of Materials Structure Science/J-PARC Center, KEK kn-affil= affil-num=11 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=1 article-no= start-page=17 end-page=22 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Sexual function before and after a tension-free vaginal mesh procedure for pelvic organ prolapse kn-title=骨盤臓器脱に対するTVM 手術前後の性機能に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract= We prospectively assessed sexual function before and after a tension-free vaginal mesh ( TVM) procedure for pelvic organ prolapse ( POP) . From April 2007 to March 2009, a total of 42 patients, who reported having an active sex life preoperatively underwent TVM for POP. Female sexual function was evaluated with the self-reporting, multiple-domain Female Sexual Function Index (FSFI) . We administered the FSFI to all of the patients before and at 3, 6, and 12 months after surgery. The mean age at surgery was 61.3±7.1 years. Before the TVM surgery, the FSFI score was very low ( 12.5±9.0) . The total FSFI score was improved significantly at 12 months after surgery ( 17.4±7.7) . The Arousal, Lubrication and Orgasm domains were significantly improved at 12 months after surgery. POP appears to have a significant negative impact on female sexual function. Our findings indicate that TVM for POP improved sexual function in a group of Japanese women with POP. en-copyright= kn-copyright= en-aut-name=MatsumotoYuko en-aut-sei=Matsumoto en-aut-mei=Yuko kn-aut-name=松本裕子 kn-aut-sei=松本 kn-aut-mei=裕子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicne, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 en-keyword=骨盤臓器脱 (pelvic organ prolapse) kn-keyword=骨盤臓器脱 (pelvic organ prolapse) en-keyword=TVM (tension-free vaginal mesh) kn-keyword=TVM (tension-free vaginal mesh) en-keyword=女性泌尿器科 (female urology) kn-keyword=女性泌尿器科 (female urology) en-keyword=性機能 (sexual function) kn-keyword=性機能 (sexual function) END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=12570 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=2015 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Metamaterial Absorbers for Infrared Detection of Molecular Self-Assembled Monolayers en-subtitle= kn-subtitle= en-abstract= kn-abstract=The emerging field of plasmonic metamaterials has introduced new degree of freedom to manipulate optical field from nano to macroscopic scale, offering an attractive platform for sensing applications. So far, metamaterial sensor concepts, however, have focused on hot-spot engineering to improve the near-field enhancement, rather than fully exploiting tailored material properties. Here, we present a novel spectroscopic technique based on the metamaterial infrared (IR) absorber allowing for a low-background detection scheme as well as significant plasmonic enhancement. Specifically, we experimentally demonstrate the resonant coupling of plasmonic modes of a metamaterial absorber and IR vibrational modes of a molecular self-assembled monolayer. The metamaterial consisting of an array of Au/MgF2/Au structures exhibits an anomalous absorption at ~3000?cm?1, which spectrally overlaps with C-H stretching vibrational modes. Symmetric/asymmetric C-H stretching modes of a 16-Mercaptohexadecanoic acid monolayer are clearly observed as Fano-like anti-resonance peaks within a broad plasmonic absorption of the metamaterial. Spectral analysis using Fano line-shape fitting reveals the underlying resonant interference in plasmon-molecular coupled systems. Our metamaterial approach achieves the attomole sensitivity with a large signal-to-noise ratio in the far-field measurement, thus may open up new avenues for realizing ultrasensitive IR inspection technologies. en-copyright= kn-copyright= en-aut-name=IshikawaAtsushi en-aut-sei=Ishikawa en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaTakuo en-aut-sei=Tanaka en-aut-mei=Takuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Electrical and Electronic Engineering, Okayama University affil-num=2 en-affil= kn-affil=Metamaterials Laboratory, RIKEN END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=6 article-no= start-page=833 end-page=840 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats kn-title=Propolis 長期投与による Otsuka Long-Evans Tokushima Fatty (OLETF) ラットの インスリン抵抗性改善作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=FujiwaraHiroki en-aut-sei=Fujiwara en-aut-mei=Hiroki kn-aut-name=藤原弘喜 kn-aut-sei=藤原 kn-aut-mei=弘喜 aut-affil-num=2 ORCID= en-aut-name=HosodaMiho en-aut-sei=Hosoda en-aut-mei=Miho kn-aut-name=細田美穂 kn-aut-sei=細田 kn-aut-mei=美穂 aut-affil-num=3 ORCID= en-aut-name=HinoHayato en-aut-sei=Hino en-aut-mei=Hayato kn-aut-name=日野隼人 kn-aut-sei=日野 kn-aut-mei=隼人 aut-affil-num=4 ORCID= en-aut-name=HiraiKazuhiro en-aut-sei=Hirai en-aut-mei=Kazuhiro kn-aut-name=平井和浩 kn-aut-sei=平井 kn-aut-mei=和浩 aut-affil-num=5 ORCID= en-aut-name=OkamotoKazuaki en-aut-sei=Okamoto en-aut-mei=Kazuaki kn-aut-name=岡本和明 kn-aut-sei=岡本 kn-aut-mei=和明 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=金? kn-aut-sei=金 kn-aut-mei=? aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高木志真 kn-aut-sei=高木 kn-aut-mei=志真 aut-affil-num=9 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川ｱ博己 kn-aut-sei=川ｱ kn-aut-mei=博己 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=8 en-affil= kn-affil=日本新薬株式会社創薬研究所 affil-num=9 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=propolis kn-keyword=propolis en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=Otsuka Long-Evans Tokushima Fatty rat kn-keyword=Otsuka Long-Evans Tokushima Fatty rat en-keyword=periarterial nerve function kn-keyword=periarterial nerve function en-keyword=mesenteric vascular bed kn-keyword=mesenteric vascular bed END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=6 article-no= start-page=349 end-page=361 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=201412 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Protective Effect of Eicosapentaenoic Acid on Insulin Resistance in Hyperlipidemic Patients and on the Postoperative Course of Cardiac Surgery Patients: The Possible Involvement of Adiponectin en-subtitle= kn-subtitle= en-abstract= kn-abstract=Accumulated studies have shown that ω-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have protective roles against inflammatory responses such as hyperlipidemia, diabetes mellitus (DM) and cardiovascular diseases. Here we examined the effects of administering EPA to hyperlipidemic patients and other patients undergoing cardiac surgery to determine whether this treatment would increase plasma EPA levels and to clarify the association between EPA treatment and adiponectin production in hyperlipidemic patients. We also assessed the effect of preoperative EPA administration on postoperative adverse events such as postoperative atrial fibrillation (POAF) and postoperative infection in the cardiac surgery patients. The EPA administration significantly increased the serum EPA concentrations in both patient populations (p＜0.001). In the hyperlipidemic patients, the EPA administration significantly increased plasma adiponectin levels (p＜0.05), accompanied by a decrease in insulin resistance designated by the HOMA-IR (homeostasis model assessment of insulin resistance) score (p＜0.05) and Hs-CRP (high sensitivity C-reactive protein) value (p＜0.05). In the cardiac surgery patients, no significant effect of EPA on cardiac adverse events such as POAF was observed. However, our results clearly demonstrated that both the neutrophil-to-lymphocyte ratio and the 2nd-line antibiotic requirement in the EPA group were significantly decreased compared to the untreated control group (p＜0.05). We suggest that EPA administration may exert anti-inflammatory effects in patients with hyperlipidemia and in those undergoing cardiac surgery, possibly through an increase in plasma adiponectin levels. en-copyright= kn-copyright= en-aut-name=YamamotoTsuyoshi en-aut-sei=Yamamoto en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KajikawaYutaka en-aut-sei=Kajikawa en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OtaniSatoru en-aut-sei=Otani en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamadaYuki en-aut-sei=Yamada en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakemotoSyunji en-aut-sei=Takemoto en-aut-mei=Syunji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HirotaMinoru en-aut-sei=Hirota en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IkedaMasae en-aut-sei=Ikeda en-aut-mei=Masae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SaitoShinya en-aut-sei=Saito en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Iwakuni Clinical Center, National Hospital Organization affil-num=2 en-affil= kn-affil=Fukuyama Medical Center,National Hospital Organization affil-num=3 en-affil= kn-affil=Iwakuni Clinical Center, National Hospital Organization affil-num=4 en-affil= kn-affil=Iwakuni Clinical Center, National Hospital Organization affil-num=5 en-affil= kn-affil=Fukuyama Medical Center,National Hospital Organization affil-num=6 en-affil= kn-affil=Fukuyama Medical Center,National Hospital Organization affil-num=7 en-affil= kn-affil=Fukuyama Medical Center,National Hospital Organization affil-num=8 en-affil= kn-affil=Fukuyama Medical Center,National Hospital Organization affil-num=9 en-affil= kn-affil=Graduate School of Health Sciences, Okayama University affil-num=10 en-affil= kn-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=eicosapentaenoic acid kn-keyword=eicosapentaenoic acid en-keyword=adiponectin kn-keyword=adiponectin en-keyword=hyperlipidemic patients kn-keyword=hyperlipidemic patients en-keyword=cardiac surgery kn-keyword=cardiac surgery en-keyword=atrial fibrillation kn-keyword=atrial fibrillation END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=9 article-no= start-page=1720 end-page=1727 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=201109 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Liposomal Delivery of MicroRNA-7-Expressing Plasmid Overcomes Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Resistance in Lung Cancer Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) have been strikingly effective in lung cancers harboring activating EGFR mutations. Unfortunately, the cancer cells eventually acquire resistance to EGFR-TKI. Approximately 50% of the acquired resistance involves a secondary T790M mutation. To overcome the resistance, we focused on EGFR suppression using microRNA-7 (miR-7), targeting multiple sites in the 30-untranslated region of EGFR mRNA. Two EGFR-TKI-sensitive cell lines (PC-9 and H3255) and two EGFR-TKI-resistant cell lines harboring T790M (RPC-9 and H1975) were used. We constructed miR-7-2 containing miR-7-expressing plasmid. After transfection of the miR-7-expressing plasmid, using cationic liposomes, a quantitative PCR and dual luciferase assay were conducted to examine the efficacy. The antiproliferative effect was evaluated using a cell count assay and xenograft model. Protein expression was examined by Western blotting. The miR-7 expression level of the transfectants was approximately 30-fold higher, and the luciferase activity was ablated by 92%. miR-7 significantly inhibited cell growth not only in PC-9 and H3255 but also in RPC-9 and H1975. Expression of insulin receptor substrate-1 (IRS-1), RAF-1, and EGFR was suppressed in the four cell lines. Injection of the miR-7-expressing plasmid revealed marked tumor regression in a mouse xenograft model using RPC-9 and H1975. EGFR, RAF-1, and IRS-1 were suppressed in the residual tumors. These findings indicate promising therapeutic applications of miR-7-expressing plasmids against EGFR oncogene-addicted lung cancers including T790M resistance by liposomal delivery. Mol Cancer Ther; 10(9); 1720-7. en-copyright= kn-copyright= en-aut-name=RaiKammei en-aut-sei=Rai en-aut-mei=Kammei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakigawaNagio en-aut-sei=Takigawa en-aut-mei=Nagio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ItoSachio en-aut-sei=Ito en-aut-mei=Sachio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KashiharaHiromi en-aut-sei=Kashihara en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IchiharaEiki en-aut-sei=Ichihara en-aut-mei=Eiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YasudaTatsuji en-aut-sei=Yasuda en-aut-mei=Tatsuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShimizuKenji en-aut-sei=Shimizu en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol & Resp Med affil-num=2 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol & Resp Med affil-num=3 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Genet affil-num=4 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol & Resp Med affil-num=5 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol & Resp Med affil-num=6 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Chem affil-num=7 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Mol Genet affil-num=8 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol & Resp Med affil-num=9 en-affil= kn-affil=Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Hematol Oncol & Resp Med END start-ver=1.4 cd-journal=joma no-vol=81 cd-vols= no-issue=5 article-no= start-page=053701-1 end-page=053701-4 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120406 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Superconductivity Induced by Bond Breaking in the Triangular Lattice of IrTe2 en-subtitle= kn-subtitle= en-abstract= kn-abstract=IrTe2, a layered compound with a triangular iridium lattice, exhibits a structural phase transition at approximately 250 K. This transition is characterized by the formation of Ir-Ir bonds along the b-axis. We found that the breaking of Ir-Ir bonds that occurs in Ir1-xPtxTe2 results in the appearance of a structural critical point in the T = 0 limit at x(c) similar or equal to 0.035. Although both IrTe2 and PtTe2 are paramagnetic metals, superconductivity at T-c = 3.1 K is induced by the bond breaking in a narrow range of x >= x(c) in Ir1-xPtxTe2. This result indicates that structural fluctuations can be involved in the emergence of superconductivity. en-copyright= kn-copyright= en-aut-name=PyonSunseng en-aut-sei=Pyon en-aut-mei=Sunseng kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KudoKazutaka en-aut-sei=Kudo en-aut-mei=Kazutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NoharaMinoru en-aut-sei=Nohara en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Department of Physics, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=Department of Physics, Faculty of Science, Okayama University affil-num=3 en-affil= kn-affil=Department of Physics, Faculty of Science, Okayama University en-keyword=superconductivity kn-keyword=superconductivity en-keyword=IrTe2 kn-keyword=IrTe2 en-keyword=Pt doping kn-keyword=Pt doping en-keyword=triangular lattice kn-keyword=triangular lattice en-keyword=phase diagram kn-keyword=phase diagram en-keyword=structural phase transition kn-keyword=structural phase transition END start-ver=1.4 cd-journal=joma no-vol=100 cd-vols= no-issue=25 article-no= start-page=252104-1 end-page=252104-3 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120619 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Enhanced thermoelectric properties by Ir doping of PtSb2 with pyrite structure en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of Ir doping on the thermoelectric properties of Pt1-xIrxSb2 (x = 0, 0.01, 0.03, and 0.1) with pyrite structure were studied. Measurements of electrical resistivity rho, Seebeck coefficient S, and thermal conductivity kappa were conducted. The results showed an abrupt change from semiconducting behavior without Ir (x = 0) to metallic behavior at x = 0.01. The sample with x = 0.01 exhibited large S and low rho, resulting in a maximum power factor (S-2/rho) of 43 mu W/cmK(2) at 400 K. The peculiar "pudding mold"-type electronic band dispersion could explain the enhanced thermoelectric properties in the metallic state. en-copyright= kn-copyright= en-aut-name=NishikuboYoshihiro en-aut-sei=Nishikubo en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakanoSeiya en-aut-sei=Nakano en-aut-mei=Seiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KudoKazutaka en-aut-sei=Kudo en-aut-mei=Kazutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NoharaMinoru en-aut-sei=Nohara en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Physics, Okayama University affil-num=2 en-affil= kn-affil=Department of Physics, Okayama University affil-num=3 en-affil= kn-affil=Department of Physics, Okayama University affil-num=4 en-affil= kn-affil=Department of Physics, Okayama University END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=3 article-no= start-page=1 end-page=12 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on the Concept of Accounting Profit and Taxable Income, and the Policy for Their Coordination System kn-title=企業利益と課税所得の概念と調整関係の今後の方向性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper first refers to the key concept of accounting profit and taxable income. Taxable income is recognized at the time of realization because it should be bearable under tax burden and can legally settle an interest in related parties. Accounting profit, defined as 'comprehensive income', is recognized and measured as the amount of periodic increase in net assets. This major difference was caused by the paradigm shift, such as the main purpose of financial reporting system was converted into the decision usefulness. This paper secondly clarifies the relationship between accounting profit and taxable income. Corporate tax law provides that taxable income is coordinated with annual closing profit based on GAAPs. Cumulative issuances of accounting standards for purpose of the global convergence brought difficulties in this coordination process. It might be more complicated when the IFRS is adapted to non-consolidated financial statements. Thirdly, this paper suggests the recent policy for this coordination. With regard to US enforcement of the IRS, Schedule M-3, reported on the factors of variances between profit and income in detail, has been required to attach corporate tax returns amended after the 'Enron' incident. Taxable income should be chained to GAAP profit in order to secure both proper accounting and tax purposes, and the coordination system would play an important role in our tax system after the IFRS adoption. en-copyright= kn-copyright= en-aut-name=KobayashiHiroaki en-aut-sei=Kobayashi en-aut-mei=Hiroaki kn-aut-name=小林裕明 kn-aut-sei=小林 kn-aut-mei=裕明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page=151 end-page=158 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Efficacy of interferon retreatment on interferon-resistant patients with chronic hepatitis C. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Chronic Hepatitis C can progress to end-stage liver cirrhosis or hepatocellular carcinoma. Interferon (IFN) therapy is effective in clearing the hepatitis C virus and in improving liver histology, however, few patients maintain a sustained response (SR) after IFN withdrawal. Immediate retreatment with IFN is therefore considered to be both effective and necessary, especially for patients who do not respond to the initial course of IFN therapy. All 145 patients included in the present study underwent liver biopsy, followed by a first treatment course with various IFNs (alpha2a, alpha2b, alpha, OIF or beta). If hepatitis C virus (HCV) RNA was positive after the first treatment, the patient was assigned to one of 3 groups, depending on whether his or her alanine transaminase (ALT)level was normalized (incomplete response, IR), partially responsive(PR), or non-responsive (NR). After an observational interval of 6 to 76 months, a second IFN treatment was initiated with a higher dose or the same dose of the same IFN for the IR group, and with a different IFN for the PR and NR groups. At 6 months after retreatment with IFN, the overall efficacy of the retreatment was 29.7.% In the case of the IR group, who received the same IFN, the overall efficacy was 45.2%. In patients identified as non-SR after the first treatment, who received a different type of IFN for retreatment, the overall efficacy was 18.6%. Anti-IFN antibody was not detected in most of the breakthrough cases. For some IR patients, retreatment with the same IFN was effective. Anti-IFN antibody was mostly negative, indicating that the same IFN can be used in both the first treatment and retreatment to obtain an SR. Switching to a different IFN was effective for some PR and NR patients, suggesting that changing IFN for such cases is a good therapeutic choice.

en-copyright= kn-copyright= en-aut-name=EgusaKuniyoki en-aut-sei=Egusa en-aut-mei=Kuniyoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KondoJunichi en-aut-sei=Kondo en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Fukuyama National Hospital affil-num=2 en-affil= kn-affil=Fuyama National Hospital en-keyword=chronic hepatitis C kn-keyword=chronic hepatitis C en-keyword=HCV RNA kn-keyword=HCV RNA en-keyword=breakthrough kn-keyword=breakthrough en-keyword=IFN anitibody kn-keyword=IFN anitibody en-keyword=retreatment with IFN kn-keyword=retreatment with IFN END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=4 article-no= start-page=173 end-page=177 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=200008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Results of rhabdomyosarcoma treatment in a developing country. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Fifty-one children (median age: 4.5 years; 4 months-16 years) diagnosed with rhabdomyosarcoma were treated in our center between 1980-1999. The primary sites were head and neck in 31.4%, the genito-urinary system in 21.6%, and extremities in 9.8% of the patients. The histopathologic subtypes were embryonal in 80.4%, alveolar in 9.8%, and undifferentiated in 9.8%. The majority of the patients were considered group III (47%) and group IV (25.5%) according the criteria of the Intergroup Rhabdomyosarcoma Study (IRS). Primary total tumour resection was performed in only 27.5% of the patients. The patients were treated with assigned regimens of IRS II and IRS III protocols. Radiotherapy was applied to 92.1% of the patients. Thirty-four patients (66.7%) were lost to follow up, and of the remaining 17 patients, 7 patients (41.2%) died, relapse occurred in 9 patients (52.9%) and 10 patients (58.8%) are alive. The percentage of cases lost to follow up during the first 10 years and the following 9 years of the study were 77.4% and 50%, respectively. In compliance with cancer treatment remains a major problem in developing countries.

en-copyright= kn-copyright= en-aut-name=KarakasZeynep en-aut-sei=Karakas en-aut-mei=Zeynep kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AgaogluLeyla en-aut-sei=Agaoglu en-aut-mei=Leyla kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=BinerBetul en-aut-sei=Biner en-aut-mei=Betul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DeveciogluOmer en-aut-sei=Devecioglu en-aut-mei=Omer kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AnakSema en-aut-sei=Anak en-aut-mei=Sema kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YalmanNevin en-aut-sei=Yalman en-aut-mei=Nevin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UnuvarAysegul en-aut-sei=Unuvar en-aut-mei=Aysegul kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=CelikAlaattin en-aut-sei=Celik en-aut-mei=Alaattin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=GedikogluGunduz en-aut-sei=Gedikoglu en-aut-mei=Gunduz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=University of Isatanbul affil-num=2 en-affil= kn-affil=University of Isatanbul affil-num=3 en-affil= kn-affil=University of Isatanbul affil-num=4 en-affil= kn-affil=University of Isatanbul affil-num=5 en-affil= kn-affil=University of Isatanbul affil-num=6 en-affil= kn-affil=University of Isatanbul affil-num=7 en-affil= kn-affil=University of Isatanbul affil-num=8 en-affil= kn-affil=University of Isatanbul affil-num=9 en-affil= kn-affil=University of Isatanbul en-keyword=rhabdomyosarcoma kn-keyword=rhabdomyosarcoma en-keyword=pediatric onocology kn-keyword=pediatric onocology en-keyword=chemotherapy kn-keyword=chemotherapy END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=1 article-no= start-page=19 end-page=24 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=200102 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The contribution of low affinity NGF receptor (p75NGFR) to delayed neuronal death after ischemia in the gerbil hippocampus. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The implication of low affinity nerve growth factor receptor (p75NGFR), which is believed to play a pro-apoptotic role, in delayed neuronal death (DND) after ischemia in the gerbil hippocampus was investigated. Immunohistochemistry and Western blot analysis revealed that the presence of p75 NGFR immunoreactivity (IR) was negligible in the hippocampus of the sham control gerbil but appeared clearly in CA1 neurons 3 and 4 days after 5-min transient ischemia. Terminal deoxynucleotidyl transferase-mediated UTP nick end labeling (TUNEL)

positive nuclei appeared when the level of p75NGFR IR increased. Furthermore, almost all TUNEL-positive CA1 neurons also costained for p75NGFR. These results suggest that p75NGFR contributes to DND after ischemia by an apoptotic mechanism.

en-copyright= kn-copyright= en-aut-name=BagumMossa Arujuma en-aut-sei=Bagum en-aut-mei=Mossa Arujuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyamotoOsamu en-aut-sei=Miyamoto en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MasadaTetsuya en-aut-sei=Masada en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NagahataShun-ichirou en-aut-sei=Nagahata en-aut-mei=Shun-ichirou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ToyoshimaTetsuhiko en-aut-sei=Toyoshima en-aut-mei=Tetsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Kagawa Medical University affil-num=2 en-affil= kn-affil=Kagawa Medical University affil-num=3 en-affil= kn-affil=Kagawa Medical University affil-num=4 en-affil= kn-affil=Kagawa Medical University affil-num=5 en-affil= kn-affil=Kagawa Medical University en-keyword=p75NGFR kn-keyword=p75NGFR en-keyword=apoptosis kn-keyword=apoptosis en-keyword=delayed neuronal death kn-keyword=delayed neuronal death en-keyword=ischemia kn-keyword=ischemia en-keyword=gerbil kn-keyword=gerbil END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=4 article-no= start-page=251 end-page=259 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Immunohistochemical Evaluation of Insulin-like Growth Factor I Receptor Status in Cervical Cancer Specimens en-subtitle= kn-subtitle= en-abstract= kn-abstract=

The insulin-like growth factor I receptor (IGF-IR) is exceptionally overexpressed in many cervicalcancer-derived cell lines. It is postulated that a decrease of p53 protein levels due to human papillomavirus (HPV) infection may contribute to the up-regulation of IGF-IR expression in cervical cancer cells because transcription of IGF-IR is strictly down-regulated by p53. To evaluate this fact in clinical cervical cancer specimens, we checked the expression levels and activated status of IGF-IR by immunohistochemistry. Formalin-fixed and paraffin-embedded specimens obtained by conization or hysterectomy were stained with anti-IGF-IR and with an antibody recognizing phosphorylated tyrosine at its c-terminus. The expression levels of IGF-IR were significantly high in cervical intraepithelial neoplasia (CIN) III and invasive cancer specimens. Phosphorylation of IGF-IR was promoted in all CIN and invasive cancer specimens, and its intensity was related to the promotion of lesions. Interestingly, IGF-IR overexpression was missing in the basal layer of CIN I and II lesions, whereas it was evenly distributed in CIN III and invasive cancer lesions. This IGF-IR overexpression pattern may be utilized in the diagnosis of HPV infection status in CIN lesions.

en-copyright= kn-copyright= en-aut-name=KuramotoHiroyuki en-aut-sei=Kuramoto en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HongoAtsushi en-aut-sei=Hongo en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=LiuYi-xuan en-aut-sei=Liu en-aut-mei=Yi-xuan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OjimaYojiro en-aut-sei=Ojima en-aut-mei=Yojiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakamuraKeiichiro en-aut-sei=Nakamura en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SekiNoriko en-aut-sei=Seki en-aut-mei=Noriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KodamaJunichi en-aut-sei=Kodama en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HiramatsuYuji en-aut-sei=Hiramatsu en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=5 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=7 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=8 en-affil= kn-affil=Department of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=insulin-like growth factor I receptor kn-keyword=insulin-like growth factor I receptor en-keyword=cervical cancer kn-keyword=cervical cancer en-keyword=human papillomavirus kn-keyword=human papillomavirus en-keyword=tyrosil phosphorylation kn-keyword=tyrosil phosphorylation END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=4 article-no= start-page=207 end-page=212 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Analysis of the genome of an Epstein-Barr-virus (EBV)-related herpesvirus in a cynomolgus monkey cell line (Si-IIA) en-subtitle= kn-subtitle= en-abstract= kn-abstract=

A simian cell line, Si-IIA, harboring Epstein-Barr-virus (EBV) -related herpesvirus (Si-IIA-EBV), produces malignant lymphoma in rabbits when administered by intravenous inoculation. In this study, we analyzed the Si-IIA-EBV genome and compared it with human EBV and herpesvirus macaca fascicularis 1 (HVMF 1 ), which is associated with B-cell lymphoma developing in SIV-infected immunosuppressed monkeys. DNA from Si-IIA-EBV was amplified by the polymerase chain reaction using three different primer pairs complementary to human EBV (B95-8) DNA; two of the primer pairs covered part of the long internal repeat 1 region (IR 1) and the third covered part of the BRRF 1 region. Direct sequencing of the three PCR products revealed that Si-IIA-EBV DNA had about 82% nucleotide homology to the human EBV DNA in all three regions and 92.4% homology to HVMF1 in the IR1 region. The blotting pattern by Southern blot analysis was different between Si-IIA-EBV and human EBV.

en-copyright= kn-copyright= en-aut-name=InoHideo en-aut-sei=Ino en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HayashiKazuhiko en-aut-sei=Hayashi en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YanaiHiroyuki en-aut-sei=Yanai en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TeramotoNorihiro en-aut-sei=Teramoto en-aut-mei=Norihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KoiralaTirtha Raj en-aut-sei=Koirala en-aut-mei=Tirtha Raj kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ChenHong-Li en-aut-sei=Chen en-aut-mei=Hong-Li kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkaTakashi en-aut-sei=Oka en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=AkagiTadaastu en-aut-sei=Akagi en-aut-mei=Tadaastu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University affil-num=10 en-affil= kn-affil=Okayama University en-keyword=Epstein-Barr virus kn-keyword=Epstein-Barr virus en-keyword=HVMF 1 kn-keyword=HVMF 1 en-keyword=lymphoma kn-keyword=lymphoma en-keyword=?monkey cell line kn-keyword=?monkey cell line en-keyword=PCR kn-keyword=PCR END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=1 article-no= start-page=17 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits an anticancer effect in esophageal adenocarcinoma in vitro and in vivo kn-title=Focal adhesion kinase (FAK) と Insulin-like growth factor-I receptor (IGF-IR) に対するデュアルチロシンキナーゼ阻害剤の食道腺癌における抗腫瘍効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WatanabeNobuyuki en-aut-sei=Watanabe en-aut-mei=Nobuyuki kn-aut-name=渡辺信之 kn-aut-sei=渡辺 kn-aut-mei=信之 aut-affil-num=1 ORCID= en-aut-name=TakaokaMunenori en-aut-sei=Takaoka en-aut-mei=Munenori kn-aut-name=岡宗徳 kn-aut-sei=岡 kn-aut-mei=宗徳 aut-affil-num=2 ORCID= en-aut-name=SakuramaKazufumi en-aut-sei=Sakurama en-aut-mei=Kazufumi kn-aut-name=櫻間一史 kn-aut-sei=櫻間 kn-aut-mei=一史 aut-affil-num=3 ORCID= en-aut-name=TomonoYasuko en-aut-sei=Tomono en-aut-mei=Yasuko kn-aut-name=友野靖子 kn-aut-sei=友野 kn-aut-mei=靖子 aut-affil-num=4 ORCID= en-aut-name=HatakeyamaShinji en-aut-sei=Hatakeyama en-aut-mei=Shinji kn-aut-name=畠山慎二 kn-aut-sei=畠山 kn-aut-mei=慎二 aut-affil-num=5 ORCID= en-aut-name=OhmoriOsamu en-aut-sei=Ohmori en-aut-mei=Osamu kn-aut-name=大森修 kn-aut-sei=大森 kn-aut-mei=修 aut-affil-num=6 ORCID= en-aut-name=MotokiTakayuki en-aut-sei=Motoki en-aut-mei=Takayuki kn-aut-name=元木崇之 kn-aut-sei=元木 kn-aut-mei=崇之 aut-affil-num=7 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=8 ORCID= en-aut-name=YamatsujiTomoki en-aut-sei=Yamatsuji en-aut-mei=Tomoki kn-aut-name=山辻知樹 kn-aut-sei=山辻 kn-aut-mei=知樹 aut-affil-num=9 ORCID= en-aut-name=HaisaMinoru en-aut-sei=Haisa en-aut-mei=Minoru kn-aut-name=羽井佐実 kn-aut-sei=羽井佐 kn-aut-mei=実 aut-affil-num=10 ORCID= en-aut-name=MatsuokaJunji en-aut-sei=Matsuoka en-aut-mei=Junji kn-aut-name=松岡順治 kn-aut-sei=松岡 kn-aut-mei=順治 aut-affil-num=11 ORCID= en-aut-name=BeerDavid G. en-aut-sei=Beer en-aut-mei=David G. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NagatsukaHitoshi en-aut-sei=Nagatsuka en-aut-mei=Hitoshi kn-aut-name=長塚仁 kn-aut-sei=長塚 kn-aut-mei=仁 aut-affil-num=13 ORCID= en-aut-name=TanakaNoriaki en-aut-sei=Tanaka en-aut-mei=Noriaki kn-aut-name=田中紀章 kn-aut-sei=田中 kn-aut-mei=紀章 aut-affil-num=14 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=4 en-affil= kn-affil=重井医学研究所 affil-num=5 en-affil= kn-affil=ノバルティスファーマ　筑波研究所 affil-num=6 en-affil= kn-affil=ノバルティスファーマ　筑波研究所 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=8 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=9 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=10 en-affil= kn-affil=岡山市立市民病院　外科 affil-num=11 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=12 en-affil= kn-affil=ミシガン大学　胸部外科 affil-num=13 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　口腔病理学 affil-num=14 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 affil-num=15 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・腫瘍外科学 en-keyword=focal adhesion kinase (FAK) kn-keyword=focal adhesion kinase (FAK) en-keyword=バレット食道癌 kn-keyword=バレット食道癌 en-keyword=FAK阻害剤 kn-keyword=FAK阻害剤 END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue=1 article-no= start-page=131 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Growth, Yield and Mineral Composition of Three Rice Varieties Cultivated under Salt-Affected Conditions en-subtitle= kn-subtitle= en-abstract= kn-abstract=A pot experiment was conducted to study the relative performance of IR 6,KS 282 and IR 10198-66-2 rice varieties cultivated under salt-affected conditions at EC of 6.0,9.0 12.0 dS m(-1) in a sandy clay loam soil havig ECe of 1.6 dS m(-1) treated as control. Six seedlings of 39-day old transplaned to each pot having 12 kg soil. The fertilizer as nitrophos and potassium sulphate at the rate of 57.0, 25.0 and 50.0 mg N,P and K kg(-1) soil respectively was applied at the time of transplanting while zinc sulphate at the rate of 5 mg Zn kg(-1) soil and 43.0 mg N kg(-1) of soil as additional dose were applied 19 and 30 days after transplanting respectively. Normal plant protection measures like number of tillers, panicles, paddy grains, filled and unifilled grains, yield per plant and sterility were recorded and shoot and straw samples were analysed for sodium, potassium, calcium and chloride contents. It was observed that growth and yield of all the varieties were reduced significantly with increasing soil salinity. Na/K and Na/Ca rations in shoot and straw increased significantly with increasing soil salinity. It was also observed that higher values of Na/K and Na/Ca rations in shoots affected growth parameters while higher values of these rations in straw affected yield components and grain yield. However, IR 6 having relatively lower values of Na/K and Na/Ca rations proved to be the most salt-tolerant rice among the three varieties studied. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=KambohMaqsood Ahmed kn-aut-sei=Kamboh kn-aut-mei=Maqsood Ahmed aut-affil-num=1 ORCID= en-aut-name=OkiYoko en-aut-sei=Oki en-aut-mei=Yoko kn-aut-name=沖陽子 kn-aut-sei=沖 kn-aut-mei=陽子 aut-affil-num=2 ORCID= en-aut-name=AdachiTadashi en-aut-sei=Adachi en-aut-mei=Tadashi kn-aut-name=足立忠司 kn-aut-sei=足立 kn-aut-mei=忠司 aut-affil-num=3 ORCID= en-aut-name=NariokaHajime en-aut-sei=Narioka en-aut-mei=Hajime kn-aut-name=成岡市 kn-aut-sei=成岡 kn-aut-mei=市 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 en-keyword=soil salinity kn-keyword=soil salinity en-keyword=growth and yield kn-keyword=growth and yield en-keyword=mineral compasition kn-keyword=mineral compasition en-keyword=rice varieties kn-keyword=rice varieties END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=2 article-no= start-page=45 end-page=51 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Bioactive Calcium Borosilicate Glasses for Enameling Titanium en-subtitle= kn-subtitle= en-abstract= kn-abstract=The thermal expansion coefficient of some bioactive glasses in the system CaO-SiO(2)-B(2)O(3) were adjusted to be similar to that of titanium by controlling the composition. A glass of composition 45CaO･30SiO(2)･25B(2)O(3) was selected among those as the enameling glass. A slurry was prepared by mixing the glass powder and ethanal to be developed on titanium and heated at 740℃ for 30 min. Thus treated specimen was soaked in a simulated body fluid (Kokubo solutiion). FT-IR reflection and thin film X-ray diffraction analyses indicated apatite formation on the glass coating layer within 12 h of soaking in the fluid. Thus titanium could be provided with bioactivity due to the enameling. en-copyright= kn-copyright= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name=尾坂明義 kn-aut-sei=尾坂 kn-aut-mei=明義 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=KobayashiKeizo kn-aut-sei=Kobayashi kn-aut-mei=Keizo aut-affil-num=2 ORCID= en-aut-name=HayakawaSatoshi en-aut-sei=Hayakawa en-aut-mei=Satoshi kn-aut-name=早川聡 kn-aut-sei=早川 kn-aut-mei=聡 aut-affil-num=3 ORCID= en-aut-name=OhtsukiChikara en-aut-sei=Ohtsuki en-aut-mei=Chikara kn-aut-name=大槻主税 kn-aut-sei=大槻 kn-aut-mei=主税 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Bioengineering Science affil-num=2 en-affil= kn-affil=Department of Bioengineering Science affil-num=3 en-affil= kn-affil=Department of Bioengineering Science affil-num=4 en-affil= kn-affil=Department of Bioengineering Science END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue=2 article-no= start-page=39 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Bioactivity of Nb(V) and Ta(V)-Doped Calcium Silicate Glasses en-subtitle= kn-subtitle= en-abstract= kn-abstract=Nb(2)O(5)-and Ta(2)O(5)-doped calcium si1icate glasses were soaked for various periods in a simulated body fluid(Kokubo solution) up to 30 days. Apatite formation ability of the surface of these glasses were investigated with thin-film X-ray diffraction and FT-IR reflection spectroscopy. The effects of these additive oxides on the bioactivity of CaO･SiO(2) based glass were discussed. A small amount of Nb(2)O(5) and Ta(2)O(5) suppressed the rate of silica hydrogel layer formation and the apatite formation on the surface of the glasses. The rate of the apatite nucleation on the surface of Nb(2)O(5)-doped calcium silicate glass was slower than that on the surface of Ta(2)O(5)-doped calcium silicate glass. It was concluded that the decrease in the apatite forming ability of calcium silicate glasses by these additive oxides is attributed to the suppression of formation of silica hydrogel layer which plays an important role in apatite nucleation. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ImayoshiNaoki kn-aut-sei=Imayoshi kn-aut-mei=Naoki aut-affil-num=1 ORCID= en-aut-name=HayakawaSatoshi en-aut-sei=Hayakawa en-aut-mei=Satoshi kn-aut-name=早川聡 kn-aut-sei=早川 kn-aut-mei=聡 aut-affil-num=2 ORCID= en-aut-name=OhtsukiChikara en-aut-sei=Ohtsuki en-aut-mei=Chikara kn-aut-name=大槻主税 kn-aut-sei=大槻 kn-aut-mei=主税 aut-affil-num=3 ORCID= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name=尾坂明義 kn-aut-sei=尾坂 kn-aut-mei=明義 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=2 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=3 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=4 en-affil= kn-affil=Department of Bioscience and Biotechnology END start-ver=1.4 cd-journal=joma no-vol=97 cd-vols= no-issue=9-10 article-no= start-page=805 end-page=814 dt-received= dt-revised= dt-accepted= dt-pub-year=1985 dt-pub=19851030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diagnosis of malignant lymphoma by magnetic resonance imaging kn-title=磁気共鳴画像による悪性リンパ腫の診断 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Magnetic resonance imaging (MRI) of pathological lymphnodes was reviewed in 12 patients with malignant lymphoma. We examined the characteristics of the images and T(1) values of lesions. Short SE was the most appropriate pulse sequence to delineate the lesions. It was intermediate in signal intensity between that of skeletal muscle and that of fat tissue. On IR image, the signal intensity of skeletal muscle or lung tissue was similar to that of lymphnodes, and on long SE image, that of fat tissue was similar to that of lymphnodes. It was difficult to differentiate Hodgkin's disease (HD) from non Hodgkin's lymphoma (NHL) using only T(1) values. The long SE signal intensity of the latter was higher than that of the former. The distribution of NHL was wider than that of HD. Though MRI has various problems such as long scan time and respiratory motion artifacts, it has various merits which other methods do hot have. We consider MRI to have an important role in the diagnosis and follow up of patients with malignant lymphoma. en-copyright= kn-copyright= en-aut-name=JojaIkuo en-aut-sei=Joja en-aut-mei=Ikuo kn-aut-name=上者郁夫 kn-aut-sei=上者 kn-aut-mei=郁夫 aut-affil-num=1 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=2 ORCID= en-aut-name=UedaHiroyuki en-aut-sei=Ueda en-aut-mei=Hiroyuki kn-aut-name=上田裕之 kn-aut-sei=上田 kn-aut-mei=裕之 aut-affil-num=3 ORCID= en-aut-name=NakamuraTetsuya en-aut-sei=Nakamura en-aut-mei=Tetsuya kn-aut-name=中村哲也 kn-aut-sei=中村 kn-aut-mei=哲也 aut-affil-num=4 ORCID= en-aut-name=YamamotoYoshio en-aut-sei=Yamamoto en-aut-mei=Yoshio kn-aut-name=山本淑雄 kn-aut-sei=山本 kn-aut-mei=淑雄 aut-affil-num=5 ORCID= en-aut-name=KajiMitumasa en-aut-sei=Kaji en-aut-mei=Mitumasa kn-aut-name=加地充昌 kn-aut-sei=加地 kn-aut-mei=充昌 aut-affil-num=6 ORCID= en-aut-name=TogamiIzumi en-aut-sei=Togami en-aut-mei=Izumi kn-aut-name=戸上泉 kn-aut-sei=戸上 kn-aut-mei=泉 aut-affil-num=7 ORCID= en-aut-name=NiiyaHarutaka en-aut-sei=Niiya en-aut-mei=Harutaka kn-aut-name=新屋晴孝 kn-aut-sei=新屋 kn-aut-mei=晴孝 aut-affil-num=8 ORCID= en-aut-name=ShirakamiToshiaki en-aut-sei=Shirakami en-aut-mei=Toshiaki kn-aut-name=白神敏明 kn-aut-sei=白神 kn-aut-mei=敏明 aut-affil-num=9 ORCID= en-aut-name=HayashiHidehiro en-aut-sei=Hayashi en-aut-mei=Hidehiro kn-aut-name=林英博 kn-aut-sei=林 kn-aut-mei=英博 aut-affil-num=10 ORCID= en-aut-name=KimotoShin en-aut-sei=Kimoto en-aut-mei=Shin kn-aut-name=木本真 kn-aut-sei=木本 kn-aut-mei=真 aut-affil-num=11 ORCID= en-aut-name=AonoKaname en-aut-sei=Aono en-aut-mei=Kaname kn-aut-name=青野要 kn-aut-sei=青野 kn-aut-mei=要 aut-affil-num=12 ORCID= en-aut-name=SugitaKatsuhiko en-aut-sei=Sugita en-aut-mei=Katsuhiko kn-aut-name=杉田勝彦 kn-aut-sei=杉田 kn-aut-mei=勝彦 aut-affil-num=13 ORCID= en-aut-name=UeokaHiroshi en-aut-sei=Ueoka en-aut-mei=Hiroshi kn-aut-name=上岡博 kn-aut-sei=上岡 kn-aut-mei=博 aut-affil-num=14 ORCID= en-aut-name=OhnoshiTaisuke en-aut-sei=Ohnoshi en-aut-mei=Taisuke kn-aut-name=大熨泰亮 kn-aut-sei=大熨 kn-aut-mei=泰亮 aut-affil-num=15 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=16 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=13 en-affil= kn-affil=香川県立中央病院放射線科 affil-num=14 en-affil= kn-affil=岡山大学医学部第二内科学教室 affil-num=15 en-affil= kn-affil=岡山大学医学部第二内科学教室 affil-num=16 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=magnetic resonance imaging kn-keyword=magnetic resonance imaging en-keyword=malignant lymphoma kn-keyword=malignant lymphoma en-keyword=T(1)-relaxation time kn-keyword=T(1)-relaxation time END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=2 article-no= start-page=25 end-page=30 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of Ethyl dl-Jasmonate and Ethyl dl-2-Epi-jasmonate en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ethyl dl-jasmonate (1a) and ethyl dl-2-epi-jasmonate (1b), novel constitutents in jasmin absolute from Italian Jasminum grandiflorum L, were prepared from 8-endo-(2'-cis-pentenyl)-3-oxo-2-oxa-bicyclo [3.2.1] octane, jasmine acid δ-lactone(2). Improvement of the preparation of the intermediate (9), a key precursor of (2), was made by different route via lactonization of (7) and/or (8). NMR and IR spectra (la) and (1b) are given. en-copyright= kn-copyright= en-aut-name=ToriiSigeru en-aut-sei=Torii en-aut-mei=Sigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TanakaHideo en-aut-sei=Tanaka en-aut-mei=Hideo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Industrial Chemistry affil-num=2 en-affil= kn-affil=Department of Industrial Chemistry END start-ver=1.4 cd-journal=joma no-vol=1 cd-vols= no-issue=1 article-no= start-page=44 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1966 dt-pub=19660331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Reaction of γ,γ-Dimethyl-α, β-dicarbethoxybutyrolactone with Acetyl Chloride en-subtitle= kn-subtitle= en-abstract= kn-abstract=Acetylation of γ,γ-dimethyl-α,β-dicarbethoxybutyrolactone in benzene in the presence of sodium hydride was attempted. The structure of the condensation product was assigned to O-acetyl derivative, which was converted into γ,γ-dimethyl-β-carbethoxy-α-carboxybutyrolactone whose structure is also discussed by IR spectrum. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=TakedaAkira kn-aut-sei=Takeda kn-aut-mei=Akira aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ToriiSigeru kn-aut-sei=Torii kn-aut-mei=Sigeru aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Industrial Chemistry affil-num=2 en-affil= kn-affil=Department of Industrial Chemistry END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=1 article-no= start-page=39 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=1988 dt-pub=19881122 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Amorphous Oxides Prepared from Organometallic Compounds Part2. Structure Evolution in Sodium Borosilicate Gels en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sodium borosilicate gels of compositions similar to that of Vycor(R) glass like 80SiO(2).15B(2)O(3).5Na(2)O (wt%) were prepared from hydrolysis and polycondensation of metal alkoxides under the HCl catalysis. Variation of specific surface area and porosity with temperature indicated that closed pores were opened below 400℃, and collapsed above 450℃ after the porosity reached a maximum value around 450℃. The structural evolution was examined due to IR spectra and a phase separation in the gels was observed. The solubility of the gels into 1N-HCl was studied as a function of the treatment temperature. en-copyright= kn-copyright= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name=尾坂明義 kn-aut-sei=尾坂 kn-aut-mei=明義 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=YuasaMotokazu kn-aut-sei=Yuasa kn-aut-mei=Motokazu aut-affil-num=2 ORCID= en-aut-name=MiuraYoshinari en-aut-sei=Miura en-aut-mei=Yoshinari kn-aut-name=三浦嘉也 kn-aut-sei=三浦 kn-aut-mei=嘉也 aut-affil-num=3 ORCID= en-aut-name=TakahashiKatsuaki en-aut-sei=Takahashi en-aut-mei=Katsuaki kn-aut-name=高橋克明 kn-aut-sei=高橋 kn-aut-mei=克明 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Applied Chemistry affil-num=2 en-affil= kn-affil=Sekisui Chemical Industry, Ltd. affil-num=3 en-affil= kn-affil=Department of Applied Chemistry affil-num=4 en-affil= kn-affil=Department of Applied Chemistry END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue=2 article-no= start-page=83 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19950327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of Alcohol on Bioactivity of Glasses en-subtitle= kn-subtitle= en-abstract= kn-abstract=One of the CaO,SiO(2)-based bioactive glasses(5OCaO･ 5OSiO (2) in mol%) were soaked for various periods in a simulated body fluid(SBF) with or without containing alcohols such as methanol, ethanol, and 1-propanol. Effect of the alcohols was investigated on the apatite formation on the glass surface with thin-film X-ray diffraction, FT-IR reflection spectroscopy and scanning electron microscopy. Under the presence of alcohols up to 0.1mol/l in the SBF an apatite layer was formed on the glass, while it consisted of crystallites similar in morphology but larger in size than that found for the SBF without the alcohols. It was concluded that the alcohols little influenced the the apatite forming ability of the CaO,SiO(2)-based glasses. en-copyright= kn-copyright= en-aut-name=TsuruKanji en-aut-sei=Tsuru en-aut-mei=Kanji kn-aut-name=都留寛治 kn-aut-sei=都留 kn-aut-mei=寛治 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=NishiyamaChikako kn-aut-sei=Nishiyama kn-aut-mei=Chikako aut-affil-num=2 ORCID= en-aut-name=OhtsukiChikara en-aut-sei=Ohtsuki en-aut-mei=Chikara kn-aut-name=大槻主税 kn-aut-sei=大槻 kn-aut-mei=主税 aut-affil-num=3 ORCID= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name=尾坂明義 kn-aut-sei=尾坂 kn-aut-mei=明義 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Bioengineering Science affil-num=2 en-affil= kn-affil=Department of Bioengineering Science affil-num=3 en-affil= kn-affil=Department of Bioengineering Science affil-num=4 en-affil= kn-affil=Department of Bioengineering Science END start-ver=1.4 cd-journal=joma no-vol=29 cd-vols= no-issue=2 article-no= start-page=77 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=1995 dt-pub=19950327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ultrasonic Implantation of Bioactive Glass Particles into Poly(methyl methacrylate) Substrates en-subtitle= kn-subtitle= en-abstract= kn-abstract=Poly(methyl methacrylate) substrates were immersed in suspensions containing bioactive 50CaO･50SiO(2) (mol%) glass particles (45 μm in diameter) and a 6:4 (volume fraction) mixture of ethanol and THF, and an ultrasonic energy was applied to the system. A layer of glass particles was implanted and covered more than 50% of the substrate surface. Thin film X-ray diffraction patterns and FT-IR reflection spectra indicated deposition of apatite on the glass-implanted substrates after they were soaked for 12 h in a simulated body fluid similar in apatite-deposition ability to the human blood plasma. Flake-like apatite crystallites formed on the substrate soaked in SBF for 3 days. en-copyright= kn-copyright= en-aut-name=TsuruKanji en-aut-sei=Tsuru en-aut-mei=Kanji kn-aut-name=都留寛治 kn-aut-sei=都留 kn-aut-mei=寛治 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=NishiyamaChikako kn-aut-sei=Nishiyama kn-aut-mei=Chikako aut-affil-num=2 ORCID= en-aut-name=OhtsukiChikara en-aut-sei=Ohtsuki en-aut-mei=Chikara kn-aut-name=大槻主税 kn-aut-sei=大槻 kn-aut-mei=主税 aut-affil-num=3 ORCID= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name=尾坂明義 kn-aut-sei=尾坂 kn-aut-mei=明義 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=Department of Bioengineering Science affil-num=2 en-affil= kn-affil=Department of Bioengineering Science affil-num=3 en-affil= kn-affil=Department of Bioengineering Science affil-num=4 en-affil= kn-affil=Department of Bioengineering Science END start-ver=1.4 cd-journal=joma no-vol=34 cd-vols= no-issue=1-2 article-no= start-page=39 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cytocompatibility of Silicone Elastomer Treated with Hydrogenperoxide Containing Tantalum Chloride en-subtitle= kn-subtitle= en-abstract= kn-abstract=Silicone elastomer was chemically treated at 60℃ for 7 days with 30 wt% H(2)O(2) solutions with or without TaCl(5) and soaked for various periods in a simulated body fluid(Kokubo solution) up to 21 days. Apatite formation ability of the surface of the silicone elastomer specimens was investigated with thin-film X-ray diffraction and FT-IR reflection spectroscopy. These silicone specimens did not deposit apatite or calcium phosphates, irrespective of chemical treatment. Osteoblast-like cells (MC3T3-El) derived from mouse were cultured on the specimens at 36.5℃ under 5%C0(2) and 95% humidity. Similar degree of proliferation of cells was observed at 7 days among three specimens, while the no treatment specimen after incubation for 5 days showed a lower degree of proliferation than the silicone treated with 30 wt% H(2)O(2) solutions with or without TaCl(5). Alkaline phosphatase activity of the cells proliferated on the no treatment specimen was lower than those of the silicone treated with 30 wt% H(2)O(2) solutions with or without TaCl(5). These results indicate that the cytotoxicity of the silicone could be improved by the chemical treatment with 30 wt% H(2)O(2) solutions with or without TaCl(5). en-copyright= kn-copyright= en-aut-name=HayakawaSatoshi en-aut-sei=Hayakawa en-aut-mei=Satoshi kn-aut-name=早川聡 kn-aut-sei=早川 kn-aut-mei=聡 aut-affil-num=1 ORCID= en-aut-name=ShirosakiYuki en-aut-sei=Shirosaki en-aut-mei=Yuki kn-aut-name=城崎由紀 kn-aut-sei=城崎 kn-aut-mei=由紀 aut-affil-num=2 ORCID= en-aut-name=YabutaTakeshi en-aut-sei=Yabuta en-aut-mei=Takeshi kn-aut-name=籔田武司 kn-aut-sei=籔田 kn-aut-mei=武司 aut-affil-num=3 ORCID= en-aut-name=TsuruKanji en-aut-sei=Tsuru en-aut-mei=Kanji kn-aut-name=都留寛治 kn-aut-sei=都留 kn-aut-mei=寛治 aut-affil-num=4 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=OhtsukiChikara kn-aut-sei=Ohtsuki kn-aut-mei=Chikara aut-affil-num=5 ORCID= en-aut-name=OsakaAkiyoshi en-aut-sei=Osaka en-aut-mei=Akiyoshi kn-aut-name=尾坂明義 kn-aut-sei=尾坂 kn-aut-mei=明義 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=2 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=3 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=4 en-affil= kn-affil=Department of Bioscience and Biotechnology affil-num=5 en-affil= kn-affil=Graduate School of Materials Science. Nara Institute of Science and Technology affil-num=6 en-affil= kn-affil=Department of Bioscience and Biotechnology END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=11-12 article-no= start-page=1301 end-page=1310 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=1991 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on chemotherapy for small cell lung cancer Part 1. Reversal of adriamycin resistance in human small cell lung cancer cells in culture kn-title=肺小細胞癌の化学療法に関する研究　第1編　Adriamycin 耐性ヒト肺小細胞癌細胞株の耐性解除に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Using adriamycin-resistant human small cell lung cancer cells (SBC-3/ADM), which were 30-fold more resistant to adriamycin than the parent cells (SBC-3), the ability of membrane-modifying agents to overcome the drug resistance was analyzed by a soft agar clonogenic assay. SBC-3/ADM was not circumvented by hyperthermia of 42℃ or amphotericin B at a concentration of 50μ M. Verapamil did not enhance the adriamycin cytoxicity in the SBC-3 cells at a concentration of 10μ M, but a 3.2-fold increase in the drug effect occurred in the SBC-3/ADM cells in terms of LD(70). The efflux of intracellular [H(3)] daunomycin from SBC-3/ADM cells was inhibited by verapamil, while the inhibition did not occur in the parent cells. Furthermore, quinidine (50μ M), cepharanthin (10μ M) and chloroquine (50μ M) enhanced the adriamycin cytotoxicity in the SBC-3/ADM cells. These findings suggest that some membrane-modifying agents could partially overcome the acquired resistance to adriamycin in human small cell lung cancer. en-copyright= kn-copyright= en-aut-name=YamashitaHidetoshi en-aut-sei=Yamashita en-aut-mei=Hidetoshi kn-aut-name=山下英敏 kn-aut-sei=山下 kn-aut-mei=英敏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=human small cell lung cancer cells in culture kn-keyword=human small cell lung cancer cells in culture en-keyword=ADM resistant subline kn-keyword=ADM resistant subline en-keyword=reversal of resistance kn-keyword=reversal of resistance END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=3-4 article-no= start-page=299 end-page=308 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199004 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and experimental studies on provocating and reducing mechanism of intractable pain Part 2. β-endorphin and monoamine metabolites in CSF of the patient with chronic pain -comparison of the concentration between pre- and post-stimulation of CNS kn-title=頑痛の発生および抑制に関する基礎的・臨床的研究　第2編　頑痛患者に於ける髄液中 β-endorphin および monoamine 代謝産物―中枢神経系の電気刺激前後に於ける濃度変動について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The concentration of β-endorphin-immunoreactivity (β-END-IR) and monoamine metabolites which are 3-methoxy-4-hydroxy-phenylglycol (MHPG), homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) were measured in cerebrospinal fluid (CSF) of patients with intractable pain to estimate the participation of these substances in the mechanism of intractable pain. The amount of β-END-IR and monoamine metabolites was measured with radioimmunoas-say and HPLC (hight performance liquid chromatography), respectively. Eight cases of intractable pain were treated with impantation of the stimulating electrode for pain relief. This treatment was performed in 2 ways, deep brain stimulation (DBS) done on 6 cases and spinal dorsal column stimualtion (DCS) on 2 cases. The concentrations of β-END-IR and monoamine metabolites were also estimated before and after the stimulation. No patient treated with DBS showed the elevation of β-END-IR or monoamine metabolites after the stimulation, except for one patient who showed significant increase of monoamine metabolites accompanying excellent pain relief by the stimulation. On the other hand, the two patients treated with DCS indicated significant elevation of β-END-IR as well as monoamine metabolites. Thus, both β-END and monoamines could play as important role DCS, and that monoamine could be involved in DBS for pain relief. en-copyright= kn-copyright= en-aut-name=FujiwaraNoriaki en-aut-sei=Fujiwara en-aut-mei=Noriaki kn-aut-name=藤原則章 kn-aut-sei=藤原 kn-aut-mei=則章 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳神経外科教室 en-keyword=β-endorphin kn-keyword=β-endorphin en-keyword=monoamine kn-keyword=monoamine en-keyword=pain kn-keyword=pain en-keyword=CSF kn-keyword=CSF en-keyword=stimulation of CNS kn-keyword=stimulation of CNS END start-ver=1.4 cd-journal=joma no-vol=102 cd-vols= no-issue=1-2 article-no= start-page=209 end-page=216 dt-received= dt-revised= dt-accepted= dt-pub-year=1990 dt-pub=199002 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Amplification and expression of myc-related oncogenes n adenovirus-induced tumors kn-title=アデノウイルス誘発マウス腫瘍における myc 群癌遺伝子の増幅と発現 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Amplification and expression of myc-related oncogenes were studied on adenovirus-induced tumors (D and IC) and spontaneous hapatoma (P), all of which had been successively trans-planted in C3Hf/OK mice. c-myc expression waas elevated in the D, IC anf P tumors, and a 8.9-fold amplification of c-myc was observed in the IC tumor. In the D tumor N-myc expression was elevated and a 1.9-fold amplification of N-myc was also observed. Amplification of c-myc in the IC tumor was suspected to be a result of selection for c-myc amplified cells during successive transplantation. Although expression of genes, c-myc, N-myc and E1A of adenovir-us, suppress each other, the results of this experiment, especially elevated expression of N-myc and c-myc in the D tumor, implicated deregulation of myc family genes in malignancies indiced by adenovirus. en-copyright= kn-copyright= en-aut-name=OkinoTakeshi en-aut-sei=Okino en-aut-mei=Takeshi kn-aut-name=沖野毅 kn-aut-sei=沖野 kn-aut-mei=毅 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=香川医科大学病理学講座第一病理学 en-keyword=アデノウイルス kn-keyword=アデノウイルス en-keyword=癌遺伝子 kn-keyword=癌遺伝子 en-keyword=c-myc kn-keyword=c-myc en-keyword=N-myc kn-keyword=N-myc END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=701 end-page=711 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of interstitial pneumonia of collagen vascular diseases Part 2. Examination of interleukin 2 receptor in interstitial pneumonia of collagen vascular diseases kn-title=膠原病肺の病態に関する研究　第2編　膠原病肺における血清中および気管支肺胞洗浄液中 soluble IL-2 receptor の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Abnormality of cellular immunity has been reported in the pathogenesis of collagen vascular diseases (CVD). IL-2 and IL-2 receptors play important roles as immunological regulation in CVD. In this study, the soluble forms of IL-2 receptor (sIL-2R) and IL-2 receptor positive lymphocytes (CD25) were analyzed to evaluate the role of IL-2R in the pathogenesis of interstitial pneumonia (IP) of CVD such as RA, SLE, polymyositis/dermatomyositis (PM/DM), and PSS and idiopathic interstitial pneumonia (IIP) as a disease control. High levels of sIL-2R were found in sera of patients with IP of CVD. The level of soluble IL-2R in sera of RA without IP correlated with the disease activity of the joints, while the level of sIL-2R in sera of RA with IP was higher than in that of RA without IP. Soluble IL-2R in bronchoalveolar lavage fluind (BALF) was also measured and the level was higher in IP with CVD. There were fewer IL-2R positive lymphocytes in the peripheral blood of CVD with IP than in the normal controls or IIP cases, although the serum level of sIL-2R was higher in CVD with IP and IIP than in the normal controls. These findings indicate that actibve immunological activities involving IL-2/IL-2R/sIL-2R systems play an important role in the pathogenesis of IP of CVD. en-copyright= kn-copyright= en-aut-name=YokotaSatoshi en-aut-sei=Yokota en-aut-mei=Satoshi kn-aut-name=横田聡 kn-aut-sei=横田 kn-aut-mei=聡 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=collagen vascular disease kn-keyword=collagen vascular disease en-keyword=interstitial pneumonia kn-keyword=interstitial pneumonia en-keyword=bronchoalveolar lavage kn-keyword=bronchoalveolar lavage en-keyword=soluble IL-2 receptor kn-keyword=soluble IL-2 receptor en-keyword=IL-2 receptor positive lymphocyte kn-keyword=IL-2 receptor positive lymphocyte END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=617 end-page=624 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ascorbic acid incerases 1,25-dihydroxyvitamin D(3) effect in human osteosaroma cell line MG63 kn-title=アスコルビル酸による 1,25dihydroxyvitaminD(3) 作用の増強―培養ヒト骨肉腫細胞 MG63 における検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=We eximined the interaction between 1,25-dihydroxyvitamin D(3) and ascorbic acid in the human osteosarcoma cell MG63 by measuring alkaline phosphatase (ALP) activity. Both vitamins induced ALP activity in this cell line. Simultaneous addition of both ascorbic and 1,25-dihydroxyvitamin D(3) induced much higher ALP activity than each vitamin alone. Pretreatment of MG63 with ascorbic acid or type I collagen, increased the ALP activity induced by 1,25-dihydroxyvitamin D(3). Binding assay anf immunoblotting analysis showed that the number of vitamin D receptors was increased in MG63 pretreated with ascorbic acid. In conclusion,ascorbic acid stimulates collagen production of MG63, and collagen increases the vitamin D receptor content. The increase in vitamin D receptor content potentiates the activity of 1,25-dihydroxyvitamin D(3) in this cell line. en-copyright= kn-copyright= en-aut-name=KuriharaMakoto en-aut-sei=Kurihara en-aut-mei=Makoto kn-aut-name=栗原信 kn-aut-sei=栗原 kn-aut-mei=信 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部小児科学教室 en-keyword=MG63 kn-keyword=MG63 en-keyword=1,25dihydroxyvitaminD(3) kn-keyword=1,25dihydroxyvitaminD(3) en-keyword=ascorbic acid kn-keyword=ascorbic acid en-keyword=type I coollagen kn-keyword=type I coollagen en-keyword=vitaino D recepter kn-keyword=vitaino D recepter END start-ver=1.4 cd-journal=joma no-vol=104 cd-vols= no-issue=5-6 article-no= start-page=471 end-page=482 dt-received= dt-revised= dt-accepted= dt-pub-year=1992 dt-pub=1992 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of typtophan metabolites on brain function : Electrocorticographical study kn-title=トリプトファン代謝産物のラット脳機能に対する影響の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The effects of tryptophan (Trp) metabolites administered into right cerebroventricle (1μmol) on the electrocorticograms (ECoG) of rats were studied to investigate the roles of Trp metabolites in the brain function. Kynurenine, anthranilic acid, and xanthurenic acid has no effect on ECoG until the end of recording 4 hours after the administration. 3-Hydroxykynurenine had a suppressive effect on the ECoG transitory, and kynurenic acid suppressed ECoG slightly. 3-Hydroxyanthranilic acid which is a metabolite of 3-hydroxykynurenine, induced spike discharges with a long latency (60-230 min after the administration). 3-Hydroxyanthranilic acid is thought to be metabolized to o-aminophenol, quinolinic acid and picolinic acid. Among the 3-hydroxyanthranilic acid metabolites, o-aminophenol induced spike discharges a few min after the administration, and the spike discharges a few min after the administrations, and the spike discharges lasted 60 min. On the other hand, quinolinic acid suppressed ECoG, and picolinic acid had no effect. These electrocorticographic findings suggest that 3- hydroxyanthranilc acid might induce spike discharges after metabolization to o-aminophenol. en-copyright= kn-copyright= en-aut-name=NishijimaYutaka en-aut-sei=Nishijima en-aut-mei=Yutaka kn-aut-name=西嶋寛 kn-aut-sei=西嶋 kn-aut-mei=寛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学歯学部口腔外科学第一講座 en-keyword=kynurenic acid kn-keyword=kynurenic acid en-keyword=3-hydroxyanthranilic acid kn-keyword=3-hydroxyanthranilic acid en-keyword=o-aminophenol kn-keyword=o-aminophenol en-keyword=quinolinic acid kn-keyword=quinolinic acid en-keyword=experimental seizures kn-keyword=experimental seizures END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=341 end-page=351 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis of lung cancer with interstitial pneumonia Part 1. Analysis of the clinical features of intersitial pneumonia in lung cancer kn-title=肺癌のびまん性肺線維化病態に関する研究　第1編　肺癌に随伴するびまん性間質性陰影の臨床的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clinical features and findings on chest x-ray were analyzed to clarify the relationship between lung cancer and interstitial pneumonia. Of 262 patients with lung cancer, 69 patients (26.3%) had interstitial pneumonia. Patients with interstitial pneumonia (LC with IP) were older than those without interstitial pneumonia (LC without IP). The incidence of LC with IP cases among males and smokers were 29.2% and 29.3%, respectively. There were no significant differences among histlogic types and clinical stages of lung cancer. More cases of LC with IP had cancer in the lower (42.0%) and peripheral (76.8%) areas on chest x-ray films. Cancer was frequently located within the interstitial shadow on chest x-ray film. Among 40 patients with idiopathic interstitial pneumonia associated lung cancer (IIP with LC), there were 38 males and 32 smokers. No dominant histlogic subtype of lung cancer was noted in IIP with LC, though the most frequent was adenocarcinoma (16 cases, 40%). In IIP with LC, the site of cancer was associated with active fibrotic changes in interstitial pneumonia. These data strongly suggest that carcinogenic factors were related to the fibrotic changes in interstitial pneumonia. en-copyright= kn-copyright= en-aut-name=ShibayamaTakuo en-aut-sei=Shibayama en-aut-mei=Takuo kn-aut-name=柴山卓夫 kn-aut-sei=柴山 kn-aut-mei=卓夫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Lung cancer kn-keyword=Lung cancer en-keyword=Idiopathic interstitial pneumonia kn-keyword=Idiopathic interstitial pneumonia en-keyword=Chest X-ray finding kn-keyword=Chest X-ray finding END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=3-4 article-no= start-page=359 end-page=377 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=1994 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The alteration of relaxation time and relaxivity by magnetic field strength kn-title=静磁場強度の緩和時間および緩和度におよぼす影響に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Some parameters are altered by the magnetic field strength, and a different image is obtained with the same paremeter, because of the altered magnetic field strength. The contrast effect by contrast material for MRI (Gd-DTPA) differs with the magnetic field strength. We studied the T1 and T2 relaxation time of various solutions and relaxivity of Gd-DTPA with a low (0.2tesla) and high (1.5tesla) magnetic field machine, and considered the optimal sequence. T1 relaxation time is prolonged 20〜40% at 1.5T compared with 0.2T. Using MnCI(2), the relaxivity of Gd-DTPA is 3.6〜6.8mmo1(-1) sec(-1)1. Using albumin, the relaxivity is 5.8〜12.1mmo1(-1) sec(-1)1. This difference is due to the difference in molecular size. Ti contrast, T2 contrast and signal intensity are weak with the low magnetic field machine. The signal intensity must be strengthened by changing some parameters (acquisitions, matrix, band width, etc.), and a shorter TR is suitable for T1 weighted images with a low magnetic field machine. For postcontrast T1 weighted images, shorter TR and shorter TE are useful to obtain a good contrast. More contrast material, and a longer TE is suitable for T2 weighted images wiht a low magnetic field machine. en-copyright= kn-copyright= en-aut-name=KitagawaTakahiro en-aut-sei=Kitagawa en-aut-mei=Takahiro kn-aut-name=北川尚広 kn-aut-sei=北川 kn-aut-mei=尚広 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 en-keyword=Magnetic Field Strength kn-keyword=Magnetic Field Strength en-keyword=Relaxation Time Relaxivity kn-keyword=Relaxation Time Relaxivity en-keyword=Gd-DTPA kn-keyword=Gd-DTPA en-keyword=Pulse Sequence kn-keyword=Pulse Sequence END start-ver=1.4 cd-journal=joma no-vol=105 cd-vols= no-issue=3-4 article-no= start-page=265 end-page=279 dt-received= dt-revised= dt-accepted= dt-pub-year=1993 dt-pub=1993 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical studies on hypoplastic anemia in the aged kn-title=高齢者再生不良性貧血の病態並びに治療に関する臨床的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To evaluate hypoplastic anemia (HA) in the aged, clinical and hematological findings of 88 patients with HA were analyzed. The patients were classified into 4 groups according to age (Group A : 5-24 y/o, Group B : 25-44 y/o, Group C : 45-64 y/o and Group D : 65 y/o- ). Hematological findings of patients in Group D were also compared to those of aged patients (above 65 y/o) with myelodisplastic syndrome (MDS) to clarify differentiation of HA from MDS. Items studied were severity, therapeutic response, complications, hematological findings, survival period and cause of death. The following results were obtained : 1. HA in the aged was frequently severe. 2. Responses to therapies including anabolic steroids and corticosteroids tended to be poor in the aged compared to those in younger patients. 3. Infections and diabetes mellitus were frequently observed complications in the aged. 4. Mortality in the aged was higher than that in younger patients. 57.1% of the aged died from bleeding. 5. The survival period of patients in Group C and D was shorter than that of patients in Group A and B. 6. Red blood cell count, reticulocytes and hemoglobin level in the aged were significantly lower than those in younger patients. Neutrophil and monocyte counts in the aged tended to be lower than those in younger patients. Nucleated cell counts and percentages of granulocytes and erythroblasts in the marrow were also lower in the aged. 7. The incidence of atypical hematological findings in HA were not different between the aged and younger patients. 8. In a comparison of HA in Group D and MDS in the aged, patients with HA showed severe anemia and thrombocytopenia. en-copyright= kn-copyright= en-aut-name=UetaIkuhiro en-aut-sei=Ueta en-aut-mei=Ikuhiro kn-aut-name=植田育寛 kn-aut-sei=植田 kn-aut-mei=育寛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=再生不良性貧血 kn-keyword=再生不良性貧血 en-keyword=高齢者貧血 kn-keyword=高齢者貧血 en-keyword=骨髄異形成症候群 kn-keyword=骨髄異形成症候群 END start-ver=1.4 cd-journal=joma no-vol=3 cd-vols= no-issue=1 article-no= start-page=47 end-page=56 dt-received= dt-revised= dt-accepted= dt-pub-year=1996 dt-pub=19960920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ca-bearing Rectorite Mineral from Roseki Deposits, Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several specimens of rectorite-type regularly interstratified mineral (including Ca-rich one of hydrother-mal origin) from roseki deposits together with a few rectorites were examined by chemical analysis, X-ray diffraction and IR spectroscopy. These specimens are rich in SiO2, AI2O3 and H2O in addition to considerable amounts of CaO, Na2O and K2O. The Ca content in mica-like layers ranges from a slight amount to exceeding 50% of the total interlayer population. For the Ca-bearing specimens, AI-for-Si substitution in the tetrahedral sheets of mica-like layers increases in proportion to the Ca contents. Characteristic absorption bands of 950-900 cm-1 and 700-670 cm-1 are observed in IR spectra. The bands are due to AI-for-Si substitution in the tetrahedral sheets. Judging from the chemical analysis and IR spectra, the component of mica-like layer rich in Ca is not that of mica but mainly that od margarite (brittle mica). Expansion characteristics of the Ca-rich mineral are similar to rectorite and expandable layer is close to beidellite. The mineral is somewhat less expandable than rectorite under the condition of RH70-80% (Na-saturation) and EG treatment (K-saturation). The rectorite-type Ca-rich mineral reported here is simlar to rectorite in its expansion characteristics, but the component of mica-like layers is different from that of rectorite. Mica-like layer of the mineral must be mainly composed of margarite-like layer. The mineral is mainly composed of a 1 : 1 regular interstratification of dioctahedral britlle mica (margarite) and smectite (beidellite). The mineral does not strictly correspond to rectorite, defined as a 1 : 1 interstratified mineral of dioctahedral mica and smectite. en-copyright= kn-copyright= en-aut-name=MatsudaToshihiko en-aut-sei=Matsuda en-aut-mei=Toshihiko kn-aut-name=松田敏彦 kn-aut-sei=松田 kn-aut-mei=敏彦 aut-affil-num=1 ORCID= en-aut-name=KurosakiMakoto en-aut-sei=Kurosaki en-aut-mei=Makoto kn-aut-name=黒崎誠 kn-aut-sei=黒崎 kn-aut-mei=誠 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Department of Earth Sciences, Faculty of Science, Okayama University affil-num=2 en-affil= kn-affil=LABO Japanese Language Institute en-keyword=rectorite kn-keyword=rectorite en-keyword=brittle mica/smectite kn-keyword=brittle mica/smectite en-keyword=margarite kn-keyword=margarite en-keyword=regular interstrarification kn-keyword=regular interstrarification END start-ver=1.4 cd-journal=joma no-vol=106 cd-vols= no-issue=7-8 article-no= start-page=837 end-page=846 dt-received= dt-revised= dt-accepted= dt-pub-year=1994 dt-pub=199408 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Sustaining capacity of hemopoiesis by human stromal cells in bone marrow kn-title=ヒト骨髄間質細胞の造血支持能に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A bone marrow coculturing system developed by M. Y.Gordon was modified for easier evaluation of the function of bone marrow stromal cells. In the method agar was not used, and cells were dried and stained directly on a 35-mm petri dish after culture. The sustaining capacity of hemopoiesis by human stromal cells in bone marrow obtained by this method was compared between eight young and five eldery healthy volunteers. Hemopoietic progenitor cells were obtained from young volunteers and cultures were prepared for seven days. These appeared 86±28 colonies from 10(5) non-adherent bone marrow cells on the sheet of stromal cells from the young volunteers and 89±27 colonies from the eldery. The colonies were classified into two types according to cytochemical appearance through peroxidase staining, but all of them proved to be composed of myeloid cells by enzyme-labeled antibody staining. Colonies were identified easily and accurately by the newly modified coculturing method. No difference in sustaining capacity of hemopoiesis by human stromal cells in bone marrow was found between the young and the eldery using this system. en-copyright= kn-copyright= en-aut-name=UekiKoubun en-aut-sei=Ueki en-aut-mei=Koubun kn-aut-name=植木康文 kn-aut-sei=植木 kn-aut-mei=康文 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=human marrow stromal cell kn-keyword=human marrow stromal cell en-keyword=ability to sustain hemopoiesis kn-keyword=ability to sustain hemopoiesis en-keyword=IL-6 production kn-keyword=IL-6 production en-keyword=aging kn-keyword=aging END start-ver=1.4 cd-journal=joma no-vol=111 cd-vols= no-issue=3-8 article-no= start-page=61 end-page=69 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990831 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Aging and exocrine pancreatic function evaluated by endoscopic retrograde aspiration of pure pancreatic juice kn-title=膵外分泌機能の加齢による変化 ―内視鏡的純粋膵液採取法による検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=I syudied the relationship between aging and exocrine pancreatic function by endoscopic retrograde aspiration of pure pancreatic juice (PPJ). Control subjects consisted of 65 out-patients presenting mild vague abdominal aymptoms who fulfilled the following three criteria : 1) good general condition with no known organic diseaes ; 2) no abnormality in the live, bile duct, pancreas. kidney or metabolism ; 3) no alcohol consumption. Nineteen patients with definite pancreatitis were also studied. PPJ was collected form within the pancreatic duct by endoscopic retrograde catheterization of the papilla for 10 minutes after a bolus intravenous injection of secretion (Secrepan, Eisai co., Ltd., 100 U/bpdy). Exocrine pancreatic function was evaluated three parameters as fillows : secretory volume, maximal bicarbonate concentration or bicarbonate output, and enyme (amyase and lipase) output. The ordinary duodenal secretin test was also performed. Exocrine pancreatic function (both duct-cell and acinar-cell function) was significantly reduced in the elderly. The age-associated reduction showed a different pattern between duct-cell and acinar-cell function. The degree of duct-cell dysfunction was significantly higher than that of acinar-cell dysfuntion in the elderly. Influence of aging on maximal bicarbonate concentration was more clearly demonstrated by PPJ aspiration than by the ordinary secretin test. Elderly controls showed as much exocrine dysfuction as patients with chronic pancreatitis, making it difificult to diagnose chronic pancreatitis based on the exocrine function test alone. Therfore, clinical symptoms and findings as well as imaging tests should be considered for the correct diagnosis. en-copyright= kn-copyright= en-aut-name=IshibashiTadaaki en-aut-sei=Ishibashi en-aut-mei=Tadaaki kn-aut-name=石橋忠明 kn-aut-sei=石橋 kn-aut-mei=忠明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科教室 en-keyword=加齢 kn-keyword=加齢 en-keyword=膵外分泌機能 kn-keyword=膵外分泌機能 en-keyword=内視鏡的純粋膵液採取法 kn-keyword=内視鏡的純粋膵液採取法 en-keyword=セクレチン試験 kn-keyword=セクレチン試験 en-keyword=慢性膵炎 kn-keyword=慢性膵炎 END start-ver=1.4 cd-journal=joma no-vol=114 cd-vols= no-issue=3 article-no= start-page=283 end-page=288 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=20030131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunohistchemical Study of Fas in Primary Biliary Cirrhosis kn-title=原発性胆汁性肝硬変肝組織における Fas 発現の免疫組織化学的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The expression of Fas on the epithelial cells of bile ducts was examined in liver specimens from 10 patients with primary biliary cirrhosis (PBC), and 14 patients with chronic hepatitis by both light and electron microscopy using the indirect peroxidase-labeled antibody method. In all patients with PBC, Fas was observed on the surface of epithelial cells of interlobular bile ducts. By electron microscopy, electron-dense reaction products of Fas were detected on the basolateral plasma membrane of the bile duct epithelial cells, as well as on some membranes of the endoplasmic reticulum. Fas was expressed more strongly on the surface of the epitherial cells of interlobular bile ducts in PBC than of those in chronic hepatitis. These findings suggest that increased expression of Fas on such bila ducts may play some role in the pathogenesis of PBC. en-copyright= kn-copyright= en-aut-name=KishiFumitoshi en-aut-sei=Kishi en-aut-mei=Fumitoshi kn-aut-name=貴志文俊 kn-aut-sei=貴志 kn-aut-mei=文俊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry en-keyword=Fas kn-keyword=Fas en-keyword=apoptosis kn-keyword=apoptosis en-keyword=liver kn-keyword=liver en-keyword=primary biliary cirrhosis kn-keyword=primary biliary cirrhosis en-keyword=immunoelectron microscopy kn-keyword=immunoelectron microscopy END start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=1 article-no= start-page=1 end-page=8 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20040531 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=神経シナプスにおけるエンドサイトーシス機能タンパク質‐膜リン脂質 相互作用機序の人工脂質膜を用いた解析法―岡山大学医学賞（新見賞）を受賞して― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=絹田正裕 kn-aut-sei=絹田 kn-aut-mei=正裕 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯学総合研究科　脳神経制御学 en-keyword=endocytosis kn-keyword=endocytosis en-keyword=synaptic vesicle kn-keyword=synaptic vesicle en-keyword=liposome kn-keyword=liposome en-keyword=dynamic light scattering kn-keyword=dynamic light scattering en-keyword=phospholipids kn-keyword=phospholipids END start-ver=1.4 cd-journal=joma no-vol=117 cd-vols= no-issue=1 article-no= start-page=27 end-page=33 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050520 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=腫瘍細胞におけるIGF-Iレセプターの役割と婦人科癌分子標的治療への応用 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=本郷淳司 kn-aut-sei=本郷 kn-aut-mei=淳司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院産科婦人科 en-keyword=Soluble IGF-IR kn-keyword=Soluble IGF-IR en-keyword=Tumorigenesis kn-keyword=Tumorigenesis en-keyword=Apoptosis kn-keyword=Apoptosis en-keyword=Recombinant Protein kn-keyword=Recombinant Protein en-keyword=Bystander Effect kn-keyword=Bystander Effect END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=185 end-page=191 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Treatments for pediatric malignant tumors kn-title=X 小児悪性腫瘍に対する治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ChayamaKosuke en-aut-sei=Chayama en-aut-mei=Kosuke kn-aut-name=茶山公祐 kn-aut-sei=茶山 kn-aut-mei=公祐 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　小児医科学 en-keyword=神経芽細胞腫 kn-keyword=神経芽細胞腫 en-keyword=横紋筋肉腫 kn-keyword=横紋筋肉腫 en-keyword=ウィルムス腫瘍 kn-keyword=ウィルムス腫瘍 en-keyword=肝芽腫 kn-keyword=肝芽腫 en-keyword=網膜芽細胞腫 kn-keyword=網膜芽細胞腫 END start-ver=1.4 cd-journal=joma no-vol=120 cd-vols= no-issue=2 article-no= start-page=175 end-page=184 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Therapy for hematologic diseases update : Recent advances in hematopoietic stem cell transplantation kn-title=IX 血液疾患最新の治療 ―造血細胞移植療法の進歩― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShinagawaKatsuji en-aut-sei=Shinagawa en-aut-mei=Katsuji kn-aut-name=品川克至 kn-aut-sei=品川 kn-aut-mei=克至 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院　血液・腫瘍内科 en-keyword=白血病 kn-keyword=白血病 en-keyword=悪性リンパ腫 kn-keyword=悪性リンパ腫 en-keyword=化学療法，造血細胞移植 kn-keyword=化学療法，造血細胞移植 en-keyword=骨髄非破壊的移植 kn-keyword=骨髄非破壊的移植 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=285 end-page=292 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=II Standard treatment for advanced lung cancer kn-title=II 肺癌の内科的治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiuraKatsuyuki en-aut-sei=Kiura en-aut-mei=Katsuyuki kn-aut-name=木浦勝行 kn-aut-sei=木浦 kn-aut-mei=勝行 aut-affil-num=1 ORCID= en-aut-name=TakigawaNagio en-aut-sei=Takigawa en-aut-mei=Nagio kn-aut-name=瀧川奈義夫 kn-aut-sei=瀧川 kn-aut-mei=奈義夫 aut-affil-num=2 ORCID= en-aut-name=OzeIsao en-aut-sei=Oze en-aut-mei=Isao kn-aut-name=尾瀬功 kn-aut-sei=尾瀬 kn-aut-mei=功 aut-affil-num=3 ORCID= en-aut-name=YasugiMasayuki en-aut-sei=Yasugi en-aut-mei=Masayuki kn-aut-name=八杉昌幸 kn-aut-sei=八杉 kn-aut-mei=昌幸 aut-affil-num=4 ORCID= en-aut-name=OchiNobuaki en-aut-sei=Ochi en-aut-mei=Nobuaki kn-aut-name=越智宣昭 kn-aut-sei=越智 kn-aut-mei=宣昭 aut-affil-num=5 ORCID= en-aut-name=HaradaDaijiro en-aut-sei=Harada en-aut-mei=Daijiro kn-aut-name=原田大二郎 kn-aut-sei=原田 kn-aut-mei=大二郎 aut-affil-num=6 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 血液・腫瘍・呼吸器内科学 en-keyword=放射線化学療法 kn-keyword=放射線化学療法 en-keyword=分子標的治療 kn-keyword=分子標的治療 en-keyword=血管新生阻害薬 kn-keyword=血管新生阻害薬 en-keyword=受容体チロシンキナーゼ阻害薬 kn-keyword=受容体チロシンキナーゼ阻害薬 END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=3 article-no= start-page=273 end-page=283 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=20080104 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=I The diagnosis of and therapy for breast cancer kn-title=I 乳がんの診断と治療 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=DoiharaHiroyoshi en-aut-sei=Doihara en-aut-mei=Hiroyoshi kn-aut-name=土井原博義 kn-aut-sei=土井原 kn-aut-mei=博義 aut-affil-num=1 ORCID= en-aut-name=TairaNaruto en-aut-sei=Taira en-aut-mei=Naruto kn-aut-name=平成人 kn-aut-sei=平 kn-aut-mei=成人 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 乳腺・内分泌外科 affil-num=2 en-affil= kn-affil=岡山大学医学部・歯学部附属病院 乳腺・内分泌外科 en-keyword=乳がん kn-keyword=乳がん en-keyword=診断 kn-keyword=診断 en-keyword=手術 kn-keyword=手術 en-keyword=薬物療法 kn-keyword=薬物療法 END start-ver=1.4 cd-journal=joma no-vol=39 cd-vols= no-issue=1 article-no= start-page=1 end-page=21 dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=200706 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Interreg Program in the Italy?Switzerland Border Region―Governance of cross?border cooperation between　a EU member state and a non?member state― kn-title=イタリア・スイス国境地域におけるInterreg　―EU 域内・域外協力のガバナンス― en-subtitle= kn-subtitle= en-abstract=The Community Initiative Interreg program, regional policies of the EU, started to promote cross?border cooperation between the constituent countries. By taking up one of them, the Interreg program that covers the Italy?Switzerland border region, this paper examines the actual state of the cross?border cooperation and　problems that entail in the implementation. The research suggests that the concerted efforts have made great　contribution to the development of the region, where exchanges between the two sides were traditionally　hampered by the Alps that divide them. It also suggests a success of the joint administrative structure, which　was formed by addressing the problems emerged from other programs implemented earlier. However, the　program is considered still on the beginning stage with some problems remained unsolved. Some come from　difference in their EU membership status :　Financial resources are not equally available to them : For example,　Italy, a EU member, receives financial assistance from ERDF(European Regional Development Fund), while　Switzerland, a non?member, cannot. Necessity of streamlining of the project implementation is also　suggested :　Despite the joint administration, specific projects have to go through duel procedures before starting them,　where they are required of approval of each county. Thus, the research indicates a need of dealing with these and　other problems to further promote the development of the region. kn-abstract=EU は，域内における地域間の社会的・経済的地域格差の是正を目的とする地域政策を実施している。このEU の地域政策は，各国が個別に取り組んでいる地域政策とは異なり，共同体レベルで取り組む地域政策である。EU の地域政策を実施するための資金提供手段として，欧州地域開発基金（ERDF）・欧州社会基金（ESF）・欧州農業指導保証基金（EAGGF）などから構成される構造基金があり，EU の地域政策の対象地域は，この構造基金からの援助を受けて地域開発プログラムを実行する。構造基金からの援助には，加盟国側からの発案プロジェクトに対する援助と，欧州委員会による発案プロジェクトに対する援助（共同体イニシアチブ）の２種類がある。共同体イニシアチブでは，欧州委員会によって地域開発プログラムのガイドラインが策定され，加盟国は提示されたガイドラインにしたがってプロジェクトの提案を行う。このように，共同体イニシアチブとは共同体が主体となって取り組む地域政策である。本稿で取り上げるInterreg は，共同体イニシアチブ事業の一つであり，国境を越えた地域間協力を促進させることを目的として実施されているプログラムである。Interreg は，Interreg I（１９９０−１９９３），Interreg II（１９９４−１９９９）を経て、Interreg III（２０００−２００６）までが実施されている。Interreg III にはA，B，C の区分があり，III A は国境を挟んで隣接する地域間協力（cross?border cooperation），III B はIII A よりも広い範囲を対象とする域内協力（transnational　cooperation），III C はヨーロッパを大きく東西南北の４つに区分した地域を対象とする域内協力（interregional cooperation）である。そのうちIII A の主な目は，EU 域内の国境を越えた協力関係を促進することで，EU 域内の統合を深化させることであるが，EU 域外諸国の国境地域との協力関係も対象としている。本稿の対象となるスイスはEU 加盟国ではないが，EU の隣接国としてInterregプログラムに参加している。スイスのInterreg への参加は，ヨーロッパへの統合および地域発展のためのスイス側の政策の一つであり，国境を越えた協力関係の強化，地域の競争力の強化を目的としている。この背景には，EUの拡大およびヨーロッパの政治的・経済的・社会的統合の深化，それに対するスイスの孤立化という状況がある。スイスは，１９６０年に設立された欧州自由貿易連合（EFTA）の設立当初からのメンバーであるが，EFTA 加盟国が次々にEU に加盟しEFTA を脱退した結果，現在のEFTA 加盟国は，スイス，アイスランド，ノルウェー，リヒテンシュタインの４カ国のみになっている。１９９４年，EFTA はEC と共に欧州経済地域（EEA）を発足させたが，スイスでは１９９２年に行われた国民投票によってEEA 協定の批准が否決され，EFTA 加盟国の中で唯一のEEA 不参加国となった。また，EEA 協定批准が否決された結果，EU への加盟交渉も棚上げになった。周囲をEU 加盟国に囲まれ，またEU 諸国との関係が深いスイスにとって，ヨーロッパ統合の流れから孤立することは，特に経済的な面から大い に懸念される問題である。このためスイス政府は，EU およびEEA への不参加によって被る不利益を避ける目的で，EU との間で分野別二国間協定を交渉・締結している。スイスのInterreg プログラムへの参加も対EU 政策の一つであり，特に，隣接諸国との国境地域における国境を越えた協力関係を強化することによって，国民のEU への統合に対する否定的な意識を変えようという意図を持っている。スイスの国境地域で展開されているInterreg プログラムには，(1)バーゼルを中心としたドイツ，フランス，スイス国境地域からなるオーバーライン地域，(2) ドイツ・オーストリア・スイス・リヒテンシュタインを含むアルペンライン地域，(3)フランス・スイス国境地域，そして(4)イタリア・スイス国境地域の４プログラムがある。スイスが関与するInterreg の研究としては，(1)について越境地域連携と構造を分析した伊藤（２００３），八木・若森（２００６），(3)についてジュラ地域とレマン地域の越境地域間協力の実態を示した清水・石田（２００６）がある。これらの研究は，各地域での歴史的経緯，地理的条件，経済状況といった地域特性や，これまでの越境協力活動の経験が，国境地域での協力構造やプログラムの実施状況に影響を与えていることを明らかにしている。伊藤（２００３）によれば，オーバーライン地域ではバーゼルを中心とした地域経済圏が形成されていたことから，まず民間主導で越境地域連携が組織され，国−州・県レベルといった政府レベルの地域連携へと展開していった。そしてこの地域における連携は，１９９０年代以降，Interreg プログラムによって発展していったことが指摘されている。この地域の越境協力ガバナンスの特徴としては，ドイツ，フランス，スイスの越境連携組織構造の間の同一性，対等性があげられるが（伊藤，２００３），各国ではその運営に差異が見られ，各州の分立性が高いスイス，州政府と自治体（中心都市であるフライブルク市）が中心となっているドイツ，地方の自立性が弱く中央集権的なフランスといった特徴が反映されていることが指摘されている（八木，若森，２００６）。フランス・スイス国境地域を研究した清水・石田（２００６）では，地理的要因から相互の交流が乏しかったジュラ地域と歴史的にも緊密な関係が存在していたレマン地域とでは，Interreg プログラムの進展や意義に相違があり，ジュラ地域ではInterreg によって協力関係が組織されるようになったのに対し，レマン地域ではInterreg は地域協力をさらに発展させる役割を果たしていることが指摘されている。本稿では主にInterreg II プログラムの事後評価報告書（LRDP，２００３b），およびInterreg III A プログラムの事前評価報告書（Region Lombardia et al.，２００１），中間評価報告書（IRS，２００３）に基づいて，イタリアとスイスの国境地域における地域間協力の実態を示すことにしたい。対象となる地域は，イタリアとスイスの国境地域の全域をカバーしており，フランス・スイス国境のジュラ地域と同様に，山脈が両国を隔てる自然障壁となっている。北部と南部とでは地理的・経済的特性が異なっており，さらに，東西に長く伸びた対象地域内には３つの言語圏が存在しているという複雑な状況を抱えている。同じように地域内に地理的・歴史的特性の違いを持つフランス・スイス・プログラムは２つのサブプログラムに分けられているが，イタリア・スイス・プログラムは単一のプログラムとして実施されている。以下では，イタリア・スイス間のInterreg プログラム対象地域の地理的・経済的特性を説明した上で，第３節ではInterreg II A プログラムを概観し，問題点を示す。第４節ではInterreg III A プログラムのガバナンスと資金管理の構造，Interreg 事業の現状について示す。 en-copyright= kn-copyright= en-aut-name=IshidaSatoko en-aut-sei=Ishida en-aut-mei=Satoko kn-aut-name=石田聡子 kn-aut-sei=石田 kn-aut-mei=聡子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2006 dt-pub=20060324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ラット舌咽及び迷走神経におけるASIC3含有１次知覚ニューロンの分布 kn-title=ASIC3-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia en-subtitle= kn-subtitle= en-abstract= kn-abstract=ASIC3-immunoreactivity (ir) was examined in the rat vagal and glossopharyngeal sensory ganglia. In the jugular, petrosal and nodose ganglia, 24.8%, 30.8% and 20.6% of sensory neurons, respectively, were immunoreactive for ASIC3. These neurons were observed throughout the ganglia. A double immunofluorescence method demonstrated that many ASIC3-immunoreactive (ir) neurons co-expressed calcitonin gene-related peptide (CGRP)- or vanilloid receptor subtype 1 (VRL-1)-ir in the jugular (CGRP, 77.8%; VRL-1, 28.0%) and petrosal ganglia (CGRP, 61.7%; VRL-1, 21.5%). In the nodose ganglion, however, such neurons were relatively rare (CGRP, 6.3%; VRL-1, 0.4%). ASIC3-ir neurons were mostly devoid of tyrosine hydroxylase in these ganglia. However, some ASIC3-ir neurons co-expressed calbindin D-28k in the petrosal (5.5%) and nodose ganglia (3.8%). These findings may suggest that ASIC3-containing neurons have a wide variety of sensory modalities in the vagal and glossopharyngeal sensory ganglia. en-copyright= kn-copyright= en-aut-name=FukudaTomoki en-aut-sei=Fukuda en-aut-mei=Tomoki kn-aut-name=福田朋樹 kn-aut-sei=福田 kn-aut-mei=朋樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=ASIC3 kn-keyword=ASIC3 en-keyword=CGRP kn-keyword=CGRP en-keyword=Jugular ganglion kn-keyword=Jugular ganglion en-keyword=Nodose ganglion kn-keyword=Nodose ganglion en-keyword=Petrosal ganglion kn-keyword=Petrosal ganglion en-keyword=VRL-1 kn-keyword=VRL-1 END start-ver=1.4 cd-journal=joma no-vol=1 cd-vols= no-issue= article-no= start-page=69 end-page=76 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=19910325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Polycyclic N-Hetero Compounds. XL. Reaction of Cyclic Ketones with Trisformylaminomethane en-subtitle= kn-subtitle= en-abstract=α-テトラロン、1,3-シクロヘキサンジオン、ナフタレンジオン等の環式ケトン類とホルムアミド或はトリスホルミルアミノメタン（TFAM）との反応により、多環式縮合ピリミジン誘導体を容易に合成できる事は既に報告した。この反応の一環として環式ケトンにl-メントン、d-カンファ、l-カルボン等の生理活性を有するテルペンケトン及びN-ベンジル-4-ピペリドンとジエチルサクシニルサクシネートを用いてTFAMとの反応を検討した。3種のテルペンケトン類からは予期した縮合ピリミジンとして8-イソプロピル-5-メチル-5,6,7,8-テトラヒドロキナゾリン（U）、ボルノ[2,3-d]ピリミジン（X）、及び5-イソプロペニル-8-メチル-5,6-ジヒドロキナゾリン（[）を得た。[の分離の際に[の不均化合物である5-イソプロペニル-8-メチル-5,6,7,8,-テトラヒドロキナゾリン（\）及び5-イソプロペニル-8-メチルキナゾリン（]）の生成をGC-MS及びpmrで確認したが、それらの単離には到らなかった。又、テルペンケトン類からLeuckart型反応生成物と考えられるN-ホルミルメンチルアミン（V）、N-ホルミルボルニルアミン（Y）及びN-ホルミルカルビルアミン（]T）を得た。N-ベンジル-4-ピペリドンとTFAMとの反応では、6-ベンジル-5,6,7,8-テトラヒドロピリド[4,3-d]ピリミジン（]V）が得られた。最後に、環式ジケトンジエステルであるジエチルサクシニルサクシネートとTFAMとの反応に於いては一挙に三環性の4,9-ジオキソー3,4,8,9-テトラヒドロピリミド[4,5-g]キナゾリン（]X）を得ることが出来た。得られた化合物の構造はir,mass,pmr,元素記号等で決定した。 kn-abstract=Reactions of cyclic ketones such as α-tetralone, 1,3-cyclohexanedione, or naphthalenedione with formamide or trisformylaminomethane (TFAM) have shown to form polyclic fused pyrimidines by us. Reactions of terpene ketones like l-menthone, d-camphor, l-carvone with TFAM were performed, and 8-isopropyl-5-methyl-5,6,7,8-tetrahydroquinazoline, borno[2,3-d] pyrimidine, and 5-isopropenyl-8-methyl-5,6-dihydroquinazoline were expectedly obtained from three terpenes. Minor products of 5-isopropenyl-8-methyl-5,6,7,8-tetrahydroquinazoline and 5-isopropenyl-8-methylquinazoline were formed with 5-isopropenyl-8-methyl-5,6-dihydroquinazoline by disproportionation reaction of l-carvone. Furthermore, No-formylmenthylamine, N-formylbornylamine, and N-formylcarvylamine were obtained as the Leuckart-type products terpene ketones in these reactions. The reaction of N-benzyl-4-piperidone with TFAM gave desired 6-benzyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine. The reaction of diethyl succinylsuccinate with TFAM afforded tricyclic 4,9-dioxo-3,4,8,9-tetrahydropyrimido[4,5-g]quinazoline. Above compounds were determined by the measurements of their instrumental analyses. en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=SasakiKenji kn-aut-sei=Sasaki kn-aut-mei=Kenji aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=HirotaTakashi kn-aut-sei=Hirota kn-aut-mei=Takashi aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=IwadoAkimasa kn-aut-sei=Iwado kn-aut-mei=Akimasa aut-affil-num=3 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=HirotaKazuhiro kn-aut-sei=Hirota kn-aut-mei=Kazuhiro aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学薬学部 affil-num=2 en-affil= kn-affil=岡山大学薬学部 affil-num=3 en-affil= kn-affil=岡山大学薬学部 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部 en-keyword=Cyclic ketone kn-keyword=Cyclic ketone en-keyword=Trisformylaminomethane kn-keyword=Trisformylaminomethane en-keyword=Fused pyrimidine kn-keyword=Fused pyrimidine en-keyword=Cyclization kn-keyword=Cyclization en-keyword=Reductive amination kn-keyword=Reductive amination END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue=1 article-no= start-page=131 end-page=135 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Corrosion Behavior of Silica Glass in High-Pressure Water Vapor at 300℃ kn-title=300℃の高圧水蒸気中における石英ガラスの腐食挙動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Corrosion behavior of silica glass was investigated in high-pressure water vapor and water at 300℃. A linear weight loss in water vapor and a parabolic weight loss in water were observed. The weight loss for the former was larger than that for the later. The fracture strength of the corroded silica glass increased with the content of molecular water in the glass. The strength reduction was observed for the corroded silica glass after dehydration at 400℃ for 1 day. en-copyright= kn-copyright= en-aut-name=OdaKohei en-aut-sei=Oda en-aut-mei=Kohei kn-aut-name=小田耕平 kn-aut-sei=小田 kn-aut-mei=耕平 aut-affil-num=1 ORCID= en-aut-name=TakataKatsumi en-aut-sei=Takata en-aut-mei=Katsumi kn-aut-name=高田勝美 kn-aut-sei=高田 kn-aut-mei=勝美 aut-affil-num=2 ORCID= en-aut-name=YoshioTetsuo en-aut-sei=Yoshio en-aut-mei=Tetsuo kn-aut-name=吉尾哲夫 kn-aut-sei=吉尾 kn-aut-mei=哲夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=米子工業高等専門学校物質工学科 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 en-keyword=Autoclave kn-keyword=Autoclave en-keyword=FT-IR kn-keyword=FT-IR en-keyword=Fracture strength kn-keyword=Fracture strength en-keyword=Hydrothermal treatment kn-keyword=Hydrothermal treatment en-keyword=Dehydration kn-keyword=Dehydration END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1 article-no= start-page=13 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=199902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Isolation and Purification of Nocardamine from the Validamycin Producer kn-title=バリダマイシン生成菌培養液から抗細菌性抗生物質ノカルダミンの分離・精製 en-subtitle= kn-subtitle= en-abstract=Streptomyces hygroscopicus subsp. limoneus はバリダマイシン生成菌として知られているが、その抗カビ物質以外に抗細菌性抗生物質を生成することは知られていない。われわれはその微生物がバリダマイシン非生成条件において生成する抗細菌性抗生物質を見出そうと試みた。その結果、グラム陰性細菌に活性を示す抗生物質EO-3を得たのでこれを分離・精製してノカルダミンと同定した。本報告では本抗生物質の培養条件、抗菌スペクトル、精製および同定方法について述べる。尚、この研究は平成6年度から8年度までの3年間に亙る岡山大学学内特定研究『特殊環境生物の機能開発と物質生産への応用』を分担して行ったものである。 kn-abstract=An antibacterial active against P. mirabilis was isolated from the culture of Streptomyces hygroscopicus subsp. limoneus, validamycin producer. The antibiotic was found to be produced with a non-validamycin producing condition. The antibiotic was identified as nocardamine with the analytical data, IR, 1H-NMR and 13C-NMR spectra. en-copyright= kn-copyright= en-aut-name=HigashideEiji en-aut-sei=Higashide en-aut-mei=Eiji kn-aut-name=東出栄治 kn-aut-sei=東出 kn-aut-mei=栄治 aut-affil-num=1 ORCID= en-aut-name=OmatsuYoshiharu en-aut-sei=Omatsu en-aut-mei=Yoshiharu kn-aut-name=大松義治 kn-aut-sei=大松 kn-aut-mei=義治 aut-affil-num=2 ORCID= en-aut-name=InoueSuemi en-aut-sei=Inoue en-aut-mei=Suemi kn-aut-name=井上末瑞 kn-aut-sei=井上 kn-aut-mei=末瑞 aut-affil-num=3 ORCID= en-aut-name=KimuraYoshinobu en-aut-sei=Kimura en-aut-mei=Yoshinobu kn-aut-name=木村吉伸 kn-aut-sei=木村 kn-aut-mei=吉伸 aut-affil-num=4 ORCID= en-aut-name=KanzakiHiroshi en-aut-sei=Kanzaki en-aut-mei=Hiroshi kn-aut-name=神崎浩 kn-aut-sei=神崎 kn-aut-mei=浩 aut-affil-num=5 ORCID= en-aut-name=NakajimaShuhei en-aut-sei=Nakajima en-aut-mei=Shuhei kn-aut-name=中島修平 kn-aut-sei=中島 kn-aut-mei=修平 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 affil-num=4 en-affil= kn-affil=岡山大学 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 en-keyword=Streptomyces kn-keyword=Streptomyces en-keyword=antibacterial compoud kn-keyword=antibacterial compoud en-keyword=nocardamine kn-keyword=nocardamine en-keyword=non-validamycin producing condition kn-keyword=non-validamycin producing condition END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=1 article-no= start-page=44 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=1974 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Isolation of Crystalline Lutein from Spinach Leaves kn-title=ホウレンソウ葉からLuteinの結晶単離について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Up to date, any precise reports on crystalline lutein, which was comprised at about 20% in carotenoids of green leaves and at about 40% in these xanthophylls, have not been found. In previous report, the authors showed that the glycocarotenoids containing galactose were existent in spinach leaves, and in the processes of these carotenoids purification lutein was found to be crystallized easily from cold acetone in considerably good yields. This crystalline lutein had mp. 174-176℃, and E1cm 1% of 2344 at 446 nm. Furthermore, visible absorption spectrum, IR-spectrum, NMR-spectrum and Mass spectrum were also estimated for the identification of it. en-copyright= kn-copyright= en-aut-name=TakagiShigeaki en-aut-sei=Takagi en-aut-mei=Shigeaki kn-aut-name=高木茂明 kn-aut-sei=高木 kn-aut-mei=茂明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=1 article-no= start-page=28 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1974 dt-pub=1974 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influence of Environmental Temperature on Growth of Japanese Quails kn-title=日本ウズラの成長に及ぼす温度環境の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Up to date, any precise reports on crystalline lutein, which was comprised at about 20% in carotenoids of green leaves and at about 40% in these xanthophylls, have not been found. In previous report, the authors showed that the glycocarotenoids containing galactose were existent in spinach leaves, and in the processes of these carotenoids purification lutein was found to be crystallized easily from cold acetone in considerably good yields. This crystalline lutein had mp. 174-176℃, and E1cm 1% of 2344 at 446 nm. Furthermore, visible absorption spectrum, IR-spectrum, NMR-spectrum and Mass spectrum were also estimated for the identification of it. en-copyright= kn-copyright= en-aut-name=SatoKatsunori en-aut-sei=Sato en-aut-mei=Katsunori kn-aut-name=佐藤勝紀 kn-aut-sei=佐藤 kn-aut-mei=勝紀 aut-affil-num=1 ORCID= en-aut-name=OtaKazuo en-aut-sei=Ota en-aut-mei=Kazuo kn-aut-name=太田和雄 kn-aut-sei=太田 kn-aut-mei=和雄 aut-affil-num=2 ORCID= en-aut-name=KawamotoYasuo en-aut-sei=Kawamoto en-aut-mei=Yasuo kn-aut-name=河本泰生 kn-aut-sei=河本 kn-aut-mei=泰生 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=鳥取県庁 affil-num=3 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=1 article-no= start-page=55 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=1973 dt-pub=1973 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Toxic Substances in the Flowers pf Pieris japonica kn-title=アセビの花に含まれる有害物質 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been reported that several toxic diterpenoids, Pieristoxins and Asebotoxins, were isolated from the flowers of Pieris japonica D. Don (Ericaceae). The structures of Asebotoxin-I, II, III, IV, V and VII are known, but those of Pieristoxin A, B, C and D are unknown. We isolated five diterpenoids, compound-I, II, III, IV and V, from the same flowers. The structures of these compounds were investigated. From the comparison of the spectral data and the chemical facts, compound-I, mp 190-191°, and compound-II were found to be identical with Asebotoxin-I C23H38O7, mp 196-198°, and Asebotoxin-VII C25H38O10, respectively. The IR spectrum of compound-III (mp 257-260°) was identical with that of Pieristoxin-B (mp 257°). Compound-ID: was hydrolysed to give lactic acid and desacyl Pieristoxin-B (Pieristoxin-E, mp 280-282°), which showed the same IR spectrum with compound-IV (mp 260-276°). The analysis of the NMR spectrurm of Pieristoxin-E showed the presence of the same functional groups to those of Rhodojaponin-III C20H32O6 (desacyl Asebotoxin-III, mp 285-287°). The melting point of Pieristoxin-E is close to that of Rhodojaponin-III, but those of monoacetyl Pieristoxin-E (mp 280-283°) and diacetyl Pieristoxin-E (mp 236-238°) differ from those of monoacetyl Rhodojaponin-III (Rhodojaponin-II mp 294.5-296°) and diacetyl Rhodojaponin-III(Rhodojaponin-I, mp 248.5-250°), respectively. The C-14 hydrogen signal (6.18 ppm) in the NMR spectrum of Pieristoxin-B indicates that Pieristoxin-B is 14-lactoyl Pieristoxin-E. The NMR spectrum of Pieristoxin-B is similar to that of Rhodojaponin-V (14-acetyl Rhodojaponin-III except that the signals due to the O-acetyl group in the latter is replaced by the signals due to the O-lactoyl group in the former. It is likely that Pieristoxin-B and E are identical with Asebotoxin-III and Rhodojaponin-III, respectively. The structure of compound-V C25H40O9, mp 203-205°, was shown by the chemical and spectral characteristics to be 7-acetoxy-14-propionyl Grayanotoxin-III or 7-propionyloxy-14-acetyl Grayanotoxin-III. en-copyright= kn-copyright= en-aut-name=NakamuraYukito en-aut-sei=Nakamura en-aut-mei=Yukito kn-aut-name=中村幸人 kn-aut-sei=中村 kn-aut-mei=幸人 aut-affil-num=1 ORCID= en-aut-name=SugioTsuyoshi en-aut-sei=Sugio en-aut-mei=Tsuyoshi kn-aut-name=杉尾剛 kn-aut-sei=杉尾 kn-aut-mei=剛 aut-affil-num=2 ORCID= en-aut-name=IwasaJunkichi en-aut-sei=Iwasa en-aut-mei=Junkichi kn-aut-name=岩佐順吉 kn-aut-sei=岩佐 kn-aut-mei=順吉 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=岡山大学 END