result 380 件
| JaLCDOI | 10.18926/CTED/66776 |
|---|---|
| Title Alternative | Study on the Process of Formation of Elementary School Teachers’ perspective on Social Studies -Focusing on rookie teachers- |
| FullText URL | cted_014_119.pdf |
| Author | FUKUTA, Yuka| KUWABARA, Toshinori| |
| Abstract | 本研究は，初任期の小学校教師が何を拠り所として社会科観を形成しているのか，また自身の社会科観をどのように発展させていこうとしているのかを明らかにしようとするものである。調査の結果，初任期小学校教師は，大学時代の卒業論文を書くために所属したゼミでの学びが核となり，日々の授業での子供観察や教材研究，生徒指導の経験など，新しい経験や価値観に出会うことを通して不足している部分を補いながら自身の社会科観を形成しており，社会科観は流動的であることが明らかになった。また，社会科を通して育てたい子供像については，教師のよりよい未来社会への志向が，社会科の役割に対する考えの核となっており，社会科を生徒指導や生活指導と密接に関連する教科であると認識していた。 |
| Keywords | 小学校教師 (elementary school teacher) 社会科観 (social studies perspectives) インタビュー (interview) 初任期教師 (rookie teacher) 教師のゲートキーピング (gatekeeping role of teacher) |
| Publication Title | Bulletin of Center for Teacher Education and Development, Okayama University |
| Published Date | 2024-03-29 |
| Volume | volume14 |
| Start Page | 119 |
| End Page | 133 |
| ISSN | 2186-1323 |
| language | Japanese |
| Copyright Holders | Copyright © 2024 岡山大学教師教育開発センター |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Zhao, Songhao| Shen, Lili| Li, Xiaoyi| Tao, Qiushuang| Li, Zhenhua| Xu, Caizhe| Zhou, Cuicui| Yang, Yanyan| Sang, Min| Han, Guangye| Yu, Long-Jiang| Kuang, Tingyun| Shen, Jian-Ren| Wang, Wenda| |
| Note | The version of record of this article, first published in Nature Communications, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41467-023-44055-8| |
| Published Date | 2023-12-09 |
| Publication Title | Nature Communications |
| Volume | volume14 |
| Issue | issue1 |
| Publisher | Nature Portfolio |
| Start Page | 8164 |
| ISSN | 2041-1723 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 38071196 |
| DOI | 10.1038/s41467-023-44055-8 |
| Web of Science KeyUT | 001118826100025 |
| Related Url | isVersionOf https://doi.org/10.1038/s41467-023-44055-8 |
| JaLCDOI | 10.18926/AMO/66671 |
|---|---|
| FullText URL | 78_1_053.pdf |
| Author | Ichikawa, Yukiko| Ogino, Tetsuya| |
| Abstract | Ice bags are frequently used in medical care settings for pain relief, comfort, and in some cases, whole-body cooling. This study quantifies heat energy transfer capacity of ice bags and evaluates their cooling effects on body temperature. Forty-eight healthy adults in their 20s were recruited. An ice bag wrapped in two layers of dry towel was applied to the forehead, neck, or palm of each participant for 10 min. The skin surface temperature, heat flow, and core temperature were recorded during the cooling and non-cooling periods, with energy transfer calculated by integrating heat flow over time. Over the non-cooling period, 31.4-53.6 kJ·m-2 of energy was dissipated over 10 min, whereas during the cooling period, the range increased to 180.0-218.7 kJ·m-2 over 10 min. Skin surface temperature decreased by 3.2-5.7°C, whereas core temperature was unchanged. Ice bag use augmented energy transfer by about 150-180 kJ·m-2 over 10 min, but this was insufficient for rapid whole body cooling due to the small skin-surface area in contact with the ice bag. The measured energy transfer indicated that topical ice bag application absorbs insufficient energy to affect core temperature. Quantitative assessment of energy transfer was shown to inform the safe and appropriate use of thermotherapy. |
| Keywords | cold compress fever hyperthermia thermal conductivity thermoregulation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2024-02 |
| Volume | volume78 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 53 |
| End Page | 61 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2024 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 38419315 |
| Web of Science KeyUT | 001203658200009 |
| FullText URL | fulltext20240214-01.pdf |
|---|---|
| Author | Miyamoto, Yuichi| |
| Keywords | Jugyo kenkyu Jissen kiroku Authorship Voluntary educational research associations Semantic preservation and reconstruction Connoisseurship |
| Note | © 2024, Emerald Publishing Limited. This AAM is provided for your own personal use only. It may not be used for resale, reprinting, systematic distribution, emailing, or for any other commercial purpose without the permission of the publisher.| |
| Published Date | 2024-02-05 |
| Publication Title | International Journal for Lesson and Learning Studies |
| Volume | volume13 |
| Issue | issue1 |
| Publisher | Emerald |
| ISSN | 2046-8253 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024, Emerald Publishing Limited |
| File Version | author |
| DOI | 10.1108/ijlls-05-2023-0062 |
| Web of Science KeyUT | 001155604500001 |
| Related Url | isVersionOf https://doi.org/10.1108/ijlls-05-2023-0062 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katayama, Haruyoshi| Fujimura, Atsushi| Huang, Rongsheng| Otani, Yusuke| Itano, Takuto| Fujiwara, Tomohiro| Kunisada, Toshiyuki| Nakata, Eiji| Ozaki, Toshifumi| |
| Keywords | benserazide cancer stem cell catecholamine synthase malignant peripheral nerve sheath tumor Schwann cell vesicular monoamine transporter |
| Published Date | 2024-01-26 |
| Publication Title | Cancer Science |
| Volume | volume115 |
| Issue | issue3 |
| Publisher | Wiley |
| Start Page | 871 |
| End Page | 882 |
| ISSN | 1347-9032 |
| NCID | AA11808050 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2024 The Authors. |
| File Version | publisher |
| PubMed ID | 38279513 |
| DOI | 10.1111/cas.16077 |
| Web of Science KeyUT | 001149722500001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.16077 |
| Title Alternative | Evaluator of adaptability of S. cerevisiae to grape juice using the oversxpression profiling ADOPT method |
|---|---|
| FullText URL | srfa_113_001_006.pdf |
| Author | Moriya, Hisao| Ono, Chiyuki Kohata | |
| Abstract | The authors have recently developed the overexpression profiling ADOPT method. In the ADOPT method, yeast strains overexpressing most of the genes in the budding yeast Saccharomyces cerevisiae genome are mixed and competitively cultured, and the genes overexpressed in the enriched strains are systematically identified. Furthermore, the identified genes can be used to identify bottleneck factors that are necessary but lacking for growth of S. cerevisiae under given conditions. In our previous studies, we have identified bottlenecks in artificially created stress environments in the laboratory, but in this study, we used grape juice for winemaking as an example to see if industrial bottlenecks can be identified. ADOPT experiments with sulfite-added grape juice used in conventional winemaking resulted in a strong enrichment of strains overexpressing the sulfite pump SSU1 and its transcription factor FZF1. Since enhancement of SSU1 function is known to occur in wine yeast acclimation, ADOPT was also shown to be useful in the search for industrial bottlenecks. On the other hand, no genes were strongly enriched by ADOPT in grape juice without sulfite addition, suggesting that grape juice is a balanced medium with few bottlenecks for S. cerevisiae growth. |
| Keywords | yeast S. cerevisiae overexpression wine making |
| Publication Title | Scientific Reports of the Faculty of Agriculture, Okayama University |
| Published Date | 2024-02-01 |
| Volume | volume113 |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 2186-7755 |
| language | Japanese |
| File Version | publisher |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kato, Yusuke| Kuroda, Hiroshi| Ozawa, Shin-Ichiro| Saito, Keisuke| Dogra, Vivek| Scholz, Martin| Zhang, Guoxian| de Vitry, Catherine| Ishikita, Hiroshi| Kim, Chanhong| Hippler, Michael| Takahashi, Yuichiro| Sakamoto, Wataru| |
| Keywords | post-translational modification Arabidopsis thaliana protein degradation photosystem II photo-oxidative damage tryptophan oxidation Chlamydomonas reinhardtii |
| Published Date | 2023-11-21 |
| Publication Title | eLife |
| Volume | volume12 |
| Publisher | eLife Sciences Publications |
| Start Page | RP88822 |
| ISSN | 2050-084X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Kato, Kuroda, Ozawa et al. |
| File Version | publisher |
| PubMed ID | 37986577 |
| DOI | 10.7554/eLife.88822 |
| Web of Science KeyUT | 001134641800001 |
| Related Url | isVersionOf https://doi.org/10.7554/eLife.88822 |
| Author | Nakagawa, Kei| Sakemoto, Ryuta| |
|---|---|
| Keywords | Commodity futures Factor investment Hedgen Safe have Inflation |
| Note | © 2023 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Oct. 2025.| |
| Published Date | 2023-12 |
| Publication Title | Finance Research Letters |
| Volume | volume58 |
| Publisher | Elsevier BV |
| Start Page | 104585 |
| ISSN | 1544-6123 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Elsevier Inc. |
| File Version | author |
| DOI | 10.1016/j.frl.2023.104585 |
| Web of Science KeyUT | 001098482300001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.frl.2023.104585 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Younas, Muhammad| Scholz, Martin| Marchetti, Giulia Maria| Hippler, Michael| |
| Keywords | green algae Light harvesting proteins phosphorylation/dephosphorylation photosystems |
| Published Date | 2023-01-24 |
| Publication Title | Bioscience Reports |
| Volume | volume43 |
| Issue | issue1 |
| Publisher | Portland Press |
| Start Page | BSR20220369 |
| ISSN | 0144-8463 |
| NCID | AA10637666 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Author(s). |
| File Version | publisher |
| PubMed ID | 36477263 |
| DOI | 10.1042/BSR20220369 |
| Web of Science KeyUT | 001088128100011 |
| Related Url | isVersionOf https://doi.org/10.1042/BSR20220369 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsunata, Ren| Takemoto, Masatsugu| Imai, Jun| Saito, Tatsuya| Ueno, Tomoyuki| |
| Keywords | Pressing Stator cores Magnetic cores Torque Atmospheric modeling Presses Manufacturing Mass production Axial-flux permanent magnet machine soft magnetic composite (SMC) PMSM tooth-tips torque press process semi-closed slot structure axial gap motor mass production YASA motor shoe |
| Published Date | 2023-10-04 |
| Publication Title | IEEE Access |
| Volume | volume11 |
| Publisher | Institute of Electrical and Electronics Engineers |
| Start Page | 109435 |
| End Page | 109447 |
| ISSN | 2169-3536 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Authors. |
| File Version | publisher |
| DOI | 10.1109/ACCESS.2023.3321829 |
| Web of Science KeyUT | 001086321100001 |
| Related Url | isVersionOf https://doi.org/10.1109/ACCESS.2023.3321829 |
| JaLCDOI | 10.18926/AMO/65973 |
|---|---|
| FullText URL | 77_5_511.pdf |
| Author | Sato, Kohei| Tsuji, Hironori| Yorimitsu, Masanori| Uehara, Takenori| Okazaki, Yuki| Takao, Shinichiro| Hata, Toshiaki| Fukuoka, Shiro| Noda, Tomoyuki| Kanda, Hideyuki| Ozaki, Toshifumi| |
| Abstract | Sarcopenia and malnutrition are increasing in older adults and are reported risk factors for functional impairment after hip fracture surgery. This study aimed to investigate the associations between skeletal muscle mass loss, malnutrition, and postoperative walking ability in patients with hip fracture. We retrospectively reviewed patients who underwent intertrochanteric fracture surgery at our institute. The psoas muscle index, controlling nutritional status score, and functional ambulation category (FAC) were used to evaluate skeletal muscle mass, nutritional status, and walking ability, respectively. Six months after surgery, walking ability was assessed as either “gait disturbance” or “independent gait”. Multivariate binomial logistic regression analysis, with skeletal muscle mass, nutritional status, and other factors, was used to predict the risk of being assigned to the gait disturbance group. This study included 95 patients (mean age, 85.2 years; 70 women). Sixty-six patients had low skeletal muscle mass, 35 suffered from malnutrition, and 28 had both. Malnutrition and low skeletal muscle mass were significantly associated with postoperative gait disturbance (FAC < 3). Preoperative low skeletal muscle mass and malnutrition were risk factors for postoperative poor walking ability. Further preventive interventions focusing on skeletal muscle mass and nutritional status are required. |
| Keywords | sarcopenia nutrition geriatric hip fracture psoas muscle index controlling nutritional status score |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 511 |
| End Page | 516 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899262 |
| Web of Science KeyUT | 001108661600008 |
| JaLCDOI | 10.18926/AMO/65967 |
|---|---|
| FullText URL | 77_5_451.pdf |
| Author | Okita, Atsushi| Tsukuda, Kazunori| Ino, Hideo| Mitsui, Ema| Ikeya, Nanami| Yamamoto, Sumiharu| Yokoyama, Nobuji| Bulin, Aubra| |
| Abstract | Using a Collaborative Action Research model, our research team established a one-month clinical resident training program for first- and second-year clinical residents. We created and implemented an assessment rubric to assess the residents’ progress toward independent practice in surgery, and thereby, to evaluate the program itself. The program included training in three areas: basic techniques and procedures in the operating room, surgical ward management, and academic activities. The rubric measured the residents’ performance according to three achievement levels: Level 1 (demonstration), Level 2 (active help) and Level 3 (passive help). The program and rubric implementation began in June 2019 and continued until March 2020, when the program outcomes and shortcomings were analyzed. Among nineteen clinical residents, a total of nine clinical residents participated in the study. Most participants reached achievement Level 3 for their performance of basic techniques in the operating room. Finally, we discussed ideas for improvement and drafted plans for an improved rubric to complete the action research cycle. Our research team found the rubric to be a useful tool in evaluating the status of the new clinical resident training program. |
| Keywords | resident program rubric assessment general surgery action research |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 451 |
| End Page | 460 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899256 |
| Web of Science KeyUT | 001108661600002 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Khazan, Negar| Kim, Kyu Kwang| Hansen, Jeanne N.| Singh, Niloy A.| Moore, Taylor| Snyder, Cameron W. A.| Pandita, Ravina| Strawderman, Myla| Fujihara, Michiko| Takamura, Yuta| Jian, Ye| Battaglia, Nicholas| Yano, Naohiro| Teramoto, Yuki| Arnold, Leggy A.| Hopson, Russell| Kishor, Keshav| Nayak, Sneha| Ojha, Debasmita| Sharon, Ashoke| Ashton, John M.| Wang, Jian| Milano, Michael T.| Miyamoto, Hiroshi| Linehan, David C.| Gerber, Scott A.| Kawar, Nada| Singh, Ajay P.| Tabdanov, Erdem D.| Dokholyan, Nikolay V.| Kakuta, Hiroki| Jurutka, Peter W.| Schor, Nina F.| Rowswell-Turner, Rachael B.| Singh, Rakesh K.| Moore, Richard G.| |
| Published Date | 2022-04-11 |
| Publication Title | Journal of Medicinal Chemistry |
| Volume | volume65 |
| Issue | issue8 |
| Publisher | American Chemical Society (ACS) |
| Start Page | 6039 |
| End Page | 6055 |
| ISSN | 0022-2623 |
| NCID | AA00702411 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35404047 |
| DOI | 10.1021/acs.jmedchem.1c01878 |
| Web of Science KeyUT | 000797573100012 |
| Related Url | isVersionOf https://doi.org/10.1021/acs.jmedchem.1c01878 |
| FullText URL | fulltext20231017-01.pdf |
|---|---|
| Author | Ohnuma, Kyosuke| Yamashita, Atsuko| Yasui, Norihisa| |
| Keywords | Crystallography Monellin Protein Stability Recombinant Proteins |
| Note | The version of record of this article, first published in The Protein Journal, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10930-023-10154-0| |
| Published Date | 2023-09-22 |
| Publication Title | The Protein Journal |
| Volume | volume42 |
| Issue | issue6 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 698 |
| End Page | 708 |
| ISSN | 1572-3887 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2023 |
| File Version | publisher |
| PubMed ID | 37737932 |
| DOI | 10.1007/s10930-023-10154-0 |
| Web of Science KeyUT | 001068486400001 |
| Related Url | isVersionOf https://doi.org/10.1007/s10930-023-10154-0 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ikura, Ryohei| Kajimoto, Kota| Park, Junsu| Murayama, Shunsuke| Fujiwara, Yusei| Osaki, Motofumi| Suzuki, Tomohiro| Shirakawa, Hidenori| Kitamura, Yujiro| Takahashi, Hiroaki| Ohashi, Yasumasa| Obata, Seiji| Harada, Akira| Ikemoto, Yuka| Nishina, Yuta| Uetsuji, Yasutomo| Matsuba, Go| Takashima, Yoshinori| |
| Keywords | stress-strain sensor carbon composite movable cross-link supramolecular materials polymericmaterials tough materials upcycling |
| Published Date | 2023-09-11 |
| Publication Title | ACS Polymers Au |
| Volume | volume3 |
| Issue | issue5 |
| Publisher | American Chemical Society |
| Start Page | 394 |
| End Page | 405 |
| ISSN | 2694-2453 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| DOI | 10.1021/acspolymersau.3c00010 |
| Web of Science KeyUT | 001066001800001 |
| Related Url | isVersionOf https://doi.org/10.1021/acspolymersau.3c00010 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Cheng, Yi Kai| Campéon, Benoît Denis Louis| Obata, Seiji| Nishina, Yuta| |
| Published Date | 2022-05-04 |
| Publication Title | Nanoscale Advances |
| Volume | volume4 |
| Issue | issue10 |
| Publisher | Royal Society of Chemistry (RSC) |
| Start Page | 2339 |
| End Page | 2345 |
| ISSN | 2516-0230 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 36133701 |
| DOI | 10.1039/d2na00078d |
| Web of Science KeyUT | 000790351400001 |
| Related Url | isVersionOf https://doi.org/10.1039/d2na00078d |
| FullText URL | fulltext20230828-02.pdf |
|---|---|
| Author | Ono, Ryota| Saeki, Nozomu| Kojima, Keiichi| Moriya, Hisao| Sudo, Yuki| |
| Keywords | UVA Saccharomyces cerevisiae Iodide Growth inhibition Suppressive molecule |
| Note | © 2023 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Oct. 2024.| |
| Published Date | 2023-10-15 |
| Publication Title | Biochemical and Biophysical Research Communications |
| Volume | volume677 |
| Publisher | Elsevier BV |
| Start Page | 1 |
| End Page | 5 |
| ISSN | 0006-291X |
| NCID | AA00564395 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 Elsevier Inc. |
| File Version | author |
| PubMed ID | 37523893 |
| DOI | 10.1016/j.bbrc.2023.07.048 |
| Web of Science KeyUT | 001047346900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.bbrc.2023.07.048 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tsunata, Ren| Yokomichi, Keito| Takemoto, Masatsugu| Imai, Jun| |
| Keywords | Variable flux memory motor hybrid excitation motor traction applications EV HEV six-step operation one-pulse drive output power density |
| Published Date | 2023-08-03 |
| Publication Title | IEEE Access |
| Volume | volume11 |
| Publisher | Institute of Electrical and Electronics Engineers |
| Start Page | 82024 |
| End Page | 82036 |
| ISSN | 2169-3536 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | publisher |
| DOI | 10.1109/ACCESS.2023.3301809 |
| Web of Science KeyUT | 001047221300001 |
| Related Url | isVersionOf https://doi.org/10.1109/ACCESS.2023.3301809 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Cong, Yingnan| Hou, Yufei| Jiang, Jiaming| Chen, Shuangzi| Cai, Xiaojing| |
| Keywords | energy trade complex networks topology evolutionary properties |
| Published Date | 2023-07-28 |
| Publication Title | Energies |
| Volume | volume16 |
| Issue | issue15 |
| Publisher | MDPI |
| Start Page | 5677 |
| ISSN | 1996-1073 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 by the authors. |
| File Version | publisher |
| DOI | 10.3390/en16155677 |
| Web of Science KeyUT | 001045434700001 |
| Related Url | isVersionOf https://doi.org/10.3390/en16155677 |
| JaLCDOI | 10.18926/AMO/65739 |
|---|---|
| FullText URL | 77_4_341.pdf |
| Author | Otsuka, Motoyuki| |
| Abstract | Hepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral replication and hepatocarcinogenesis mechanisms are described, with a focus on the recently reported viral replication mechanisms related to degradation of the Smc5/6 protein complex. We also discuss our recent discovery of a compound that inhibits HBx protein-induced degradation of the Smc5/6 protein complex, and that exerts inhibitory effects on both viral replication and hepatocarcinogenesis. Finally, prospects for future research on the HBx protein are described. |
| Keywords | HBx Smc5/6 DDB1 nitazoxianide DNA repair |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-08 |
| Volume | volume77 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 341 |
| End Page | 345 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37635133 |
| Web of Science KeyUT | 001163659800007 |
