result 46 件
| Title Alternative | Adenoviral p53 gene therapy for lung cancer |
|---|---|
| FullText URL | 119_229.pdf |
| Author | Fujiwara, Toshiyoshi| Tanaka, Noriaki| |
| Abstract | To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit. |
| Keywords | p53 遺伝子 アデノウイルスベクター (adenovirus vector) 肺癌 (lung cancer) 臨床試験 (clinical trial) |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2008-01-04 |
| Volume | volume119 |
| Issue | issue3 |
| Start Page | 229 |
| End Page | 234 |
| ISSN | 00301558 |
| language | Japanese |
| Copyright Holders | 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.119.229 |
| NAID | 10020282723 |
| Author | Ishii, Tatsuhiro| Murakami, Jun| Notohara, Kenji| Sasamoto, Hiromi| Kambara, Takeshi| Shirakawa, Yasuhiro| Naomoto, Yoshio| Ouchida, Mamoru| Shimizu, Kenji| Jeremy, R. Jass| Matsubara, Nagahide| Tanaka, Noriaki| |
|---|---|
| Published Date | 2007-09-03 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | 成島 道樹| Kobayashi, Naoya| 興津 輝| 田中 斎仁| 李 順愛| 陳 勇| 三木 厚| 田中 公章| 中路 修平| 竹居 孝二| Alejandro, Soto Gutierrez| Jorge, David Rivas-Carrillo| Nalu, Navarro-Alvarez| Hee-Sook, Jun| Karen, A Westerman| 野口 洋文| Jonathan, R T Lakey| Philippe, Leboulch| 田中 紀章| Ji-Won, Yoon| |
|---|---|
| Published Date | 2007-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume119 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Naomoto, Yoshio| Yamatsuji, Tomoki| Shirakawa, Yasuhiro| Takaoka, Munenori| Fujiwara, Yasuhiro| Tanabe, Shunsuke| |
|---|---|
| Published Date | 2008-05-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume120 |
| Issue | issue1 |
| Content Type | Journal Article |
| Title Alternative | In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus |
|---|---|
| FullText URL | 120_01_013_021.pdf |
| Author | Kishimoto, Hiroyuki| Kojima, Toru| Watanabe, Yuichi| Kagawa, Shunsuke| Fujiwara, Toshiya| Uno, Futoshi| Teraishi, Fuminori| Kyo, Satoru| Mizuguchi, Hiroyuki| Hashimoto, Yuuri| Urata, Yasuo| Tanaka, Noriaki| Fujiwara, Toshiyoshi| |
| Keywords | GFP アデノウイルス ヒトテロメラーゼ逆転写酵素 |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2008-05-01 |
| Volume | volume120 |
| Issue | issue1 |
| Start Page | 13 |
| End Page | 21 |
| ISSN | 00301558 |
| language | Japanese |
| Copyright Holders | 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.120.13 |
| NAID | 10024170197 |
| Author | 田中 紀章| |
|---|---|
| Published Date | 1978-06-30 |
| Publication Title | |
| Content Type | Thesis or Dissertation |
