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en-title=分光法とペーパー分析デバイスに基づく酵素活性測定法の開発
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kn-title=Fusobacterium nucleatum LPSが誘導する近位尿細管SGLT2の過剰発現による糖尿病増悪機構
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en-aut-name=SEKIAiko
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affil-num=1
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kn-title=MGST2遺伝子欠失マウスにおける磁気共鳴画像法による眼の形態学的解析
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en-aut-name=CHAOMULIGE
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aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=岡山大学大学院ヘルスシステム統合科学研究科
END

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kn-title=メチル水銀の毒性機序および新規障害部位の解析
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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kn-title=マウスを用いた味覚唾液反射機構の解明：中枢神経系のc-Fos発現
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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kn-title=口腔癌における骨髄由来間葉系幹細胞の役割 
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en-aut-name=SANOSho
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affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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dt-pub-year=2005
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en-title=キサンチンオキシダーゼ由来フリーラジカルの培養膵星細胞に及ぼす影響
kn-title=Xanthine oxidase-derived free radicals directly activate rat pancreatic stellate cells
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kn-copyright=

en-aut-name=TaniokaHiroaki
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kn-aut-mei=洋亮
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ORCID=

affil-num=1
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kn-affil=岡山大学
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dt-pub-year=2005
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en-title=
kn-title=ペルオキシダーゼを利用した酵素重合およびポリマー微粒子の調製
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kn-subtitle=
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kn-abstract=
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en-aut-name=
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kn-aut-name=単錦宇
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ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=2023
dt-pub=20230324
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en-title=
kn-title=歯周感染・炎症が妊娠や子宮組織に及ぼす影響の免疫学的検討
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kn-subtitle=
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kn-copyright=

en-aut-name=NAGATAChiaki
en-aut-sei=NAGATA
en-aut-mei=Chiaki
kn-aut-name=永田千晶 
kn-aut-sei=永田
kn-aut-mei=千晶 
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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cd-journal=joma
no-vol=112
cd-vols=
no-issue=
article-no=
start-page=13
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on l-Glutamate Oxidase with Strict Substrate Specificity from Streptomyces sp.
kn-title=Streptomyces属放線菌由来の高基質特異性l-グルタミン酸オキシダーゼに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=l-glutamate oxidase (LGOX) from Streptomyces sp. is a heterohexameric flavin enzyme that catalyzes the oxidative deamination of l-glutamate to form α-ketoglutarate with ammonia and hydrogen peroxide. LGOX shows strict substrate specificity for l-Glu. In addition, it is highly thermostable and pH stable. Because of these properties, LGOX is currently used as a biosensor for the trace determination of l-Glu in the food industry and clinical laboratories. The full-length cDNA is 2103 bp and is encoded by a single polypeptide chain consisting of 701 residues including subunits α-γ-β. The LGOX gene was heterologously expressed in Escherichia coli JM109. The LGOX precursor expressed in E. coli is a homodimer with weak enzymatic activity and becomes a heterohexamer upon activation by protease treatment. X-ray crystallography and docking studies of purified recombinant LGOX suggest that the Arg305 residue is a key residue for substrate recognition. Mutant analysis showed that Arg305 is essential for substrate recognition, as the activity toward l-Glu was greatly reduced and substrate specificity was changed in some enzymes. The functional analysis of R305E-LGOX, which is an l-Arg oxidase, revealed that R305E-LGOX can be used as a enzyme biosensor for l-Arg.
en-copyright=
kn-copyright=

en-aut-name=NakayamaNatsume
en-aut-sei=Nakayama
en-aut-mei=Natsume
kn-aut-name=中山夏女
kn-aut-sei=中山
kn-aut-mei=夏女
aut-affil-num=1
ORCID=

en-aut-name=InagakiK.
en-aut-sei=Inagaki
en-aut-mei=K.
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Course of Agrochemical Bioscience
kn-affil=農芸化学コース

affil-num=2
en-affil=
kn-affil=岡山大学学術研究院環境生命科学学域
en-keyword=l-glutamate oxidase
kn-keyword=l-glutamate oxidase
en-keyword=biosensor
kn-keyword=biosensor
en-keyword=substrate recognition
kn-keyword=substrate recognition
en-keyword=X-ray crystallography
kn-keyword=X-ray crystallography
en-keyword=modification of substrate specificity
kn-keyword=modification of substrate specificity
END

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cd-journal=joma
no-vol=112
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dt-pub-year=2023
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kn-title=目次
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END

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dt-pub-year=2022
dt-pub=20220922
dt-online=
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kn-article=
en-subject=
kn-subject=
en-title=
kn-title=レゾルビンD2は歯髄幹細胞の増殖を促進して断髄面における硬組織形成を誘導する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=

en-aut-name=YONEDAMitsuhiro
en-aut-sei=YONEDA
en-aut-mei=Mitsuhiro
kn-aut-name=米田光宏
kn-aut-sei=米田
kn-aut-mei=光宏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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dt-pub-year=2022
dt-pub=20220325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=NADPHオキシダーゼ阻害剤の抗CSC効果
kn-title=Anti-CSC effect of NADPH oxidase inhibitor
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=

en-aut-name=MonzurSadia
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kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=岡山大学大学院ヘルスシステム統合科学研究科
END

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kn-title=カキ果実の輸出および貯蔵技術に関する研究
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kn-copyright=

en-aut-name=FurutaTakahiro
en-aut-sei=Furuta
en-aut-mei=Takahiro
kn-aut-name=古田貴裕
kn-aut-sei=古田
kn-aut-mei=貴裕
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

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kn-subject=
en-title=シロイヌナズナにおけるリンゴ酸誘導気孔閉口のメカニズム
kn-title=The mechanism of malate-induced stomatal closure in Arabidopsis thaliana
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kn-subtitle=
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en-aut-name=MimataYoshiharu
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kn-aut-mei=好令
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

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dt-pub-year=2022
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kn-title=ケルセチン配糖体腸内細菌代謝物のアセトアルデヒドに対する保護作用とその分子機構
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kn-subtitle=
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kn-copyright=

en-aut-name=MyojinTakumi
en-aut-sei=Myojin
en-aut-mei=Takumi
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kn-aut-sei=明神
kn-aut-mei=匠
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

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dt-pub-year=2022
dt-pub=20220325
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kn-subject=
en-title=
kn-title=PLP依存性L-メチオニン代謝関連酵素の構造機能解析と応用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=

en-aut-name=OkawaAtsushi
en-aut-sei=Okawa
en-aut-mei=Atsushi
kn-aut-name=大川敦司
kn-aut-sei=大川
kn-aut-mei=敦司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

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cd-journal=joma
no-vol=111
cd-vols=
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dt-pub-year=2022
dt-pub=20220201
dt-online=
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kn-title=目次
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kn-subtitle=
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kn-copyright=
END

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cd-journal=joma
no-vol=111
cd-vols=
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article-no=
start-page=27
end-page=42
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dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2021
kn-title=公表学術論文等リスト　2021
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

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cd-journal=joma
no-vol=111
cd-vols=
no-issue=
article-no=
start-page=7
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2022
dt-pub=20220201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on antitumor enzyme l-lysine α-oxidase from Trichoderma viride
kn-title=糸状菌Trichoderma viride由来の抗腫瘍性酵素L-リシン α-オキシダーゼに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=L-Lysine α-oxidase (LysOX) from Trichoderma viride is a homodimeric flavoenzyme that catalyzes the oxidative deamination of L-Lysine to produce α-keto-ε-aminocaproate with ammonia and hydrogen per-oxide. LysOX inhibited the growth of cancer cells but showed relatively low toxicity for normal cells. The full-length cDNA consists of 2,119 bp, and encodes a long N-terminal propeptide composed of 77 resi-dues (Met1-Arg77) and the mature protein (Ala78-Ile617). The LysOX gene was heterologously expressed in Streptomyces lividans TK24 or Escherichia coli SoluBL21. The enzymatic properties of the purified recombinant LysOX, such as substrate specificity, kinetic parameters and thermal stability, are the same as those of the native LysOX. The LysOX precursor (prLysOX) expressed in E. coli shows weak enzymatic activity and is activated by proteolytic processing. The crystal structure of prLysOX revealed that the propeptide of prLysOX indirectly changes the active site structure to inhibit enzyme activity. Moreover, the crystal structures of LysOX and its L-Lysine complex revealed that the hydrogen bonding network formed by Asp212, Asp315 and Ala440 with two water molecules is responsible for the recogni-tion of the ε-amino group of L-Lysine. In addition, a narrow substrate-binding site and acidic surface at the active site entrance both contribute to strict substrate specificity. Mutational analysis demonstrated that Asp212 and Asp315 are essential for substrate recognition, and the D212A/D315A LysOX prefers aromatic amino acids. Furthermore, the structural basis of the substrate specificity change has also been revealed by the structural analysis of the D212A/D315A LysOX and its substrate complexes. 
en-copyright=
kn-copyright=

en-aut-name=SaitoMasaya
en-aut-sei=Saito
en-aut-mei=Masaya
kn-aut-name=齋藤雅哉
kn-aut-sei=齋藤
kn-aut-mei=雅哉
aut-affil-num=1
ORCID=

en-aut-name=InagakiKenji
en-aut-sei=Inagaki
en-aut-mei=Kenji
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Course of Agrochemical Bioscience
kn-affil=岡山大学農学部農芸化学コース

affil-num=2
en-affil=
kn-affil=学術研究院環境生命科学学域
en-keyword=L-lysine α-oxidase
kn-keyword=L-lysine α-oxidase
en-keyword=antitumor enzyme
kn-keyword=antitumor enzyme
en-keyword=substrate recognition
kn-keyword=substrate recognition
en-keyword=X-ray crystallography
kn-keyword=X-ray crystallography
en-keyword=enzyme activity regulation
kn-keyword=enzyme activity regulation
END

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dt-pub-year=2021
dt-pub=20210325
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kn-subject=
en-title=
kn-title=APPノックインマウスを用いた咬合支持の欠如によるアミロイドβ沈着の変化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurakamiAsuka
en-aut-sei=Murakami
en-aut-mei=Asuka
kn-aut-name=村上明日香
kn-aut-sei=村上
kn-aut-mei=明日香
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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article-no=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=骨粗鬆症モデルマウスにおける真菌二次代謝産物(+)-Terreinが骨代謝に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SakaidaKyosuke
en-aut-sei=Sakaida
en-aut-mei=Kyosuke
kn-aut-name=坂井田京佑
kn-aut-sei=坂井田
kn-aut-mei=京佑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=
article-no=
start-page=15
end-page=31
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2021
dt-pub=20210201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2020.
kn-title=公表学術論文等リスト　2020
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
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dt-pub-year=2020
dt-pub=20200925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=G-CSF刺激により誘導される好中球分化におけるGab2の役割
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=趙香琳
kn-aut-sei=趙
kn-aut-mei=香琳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
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dt-received=
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dt-pub-year=2020
dt-pub=20200925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=促進性グルコーストランスポーターGLUT12の機能と発現に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松尾俊佑
kn-aut-sei=松尾
kn-aut-mei=俊佑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
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article-no=
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dt-accepted=
dt-pub-year=2020
dt-pub=20200925
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ヒト培養細胞におけるタンパク質発現限界を体系的に測定する実験方法の開発
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=森吉弘
kn-aut-sei=森
kn-aut-mei=吉弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=27
cd-vols=
no-issue=
article-no=
start-page=1
end-page=63
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Annual report / Institute of Plant Science and Resources, Okayama University
kn-title=岡山大学資源植物科学研究所報告
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Institute of Plant Science and Resources, Okayama University
en-aut-sei=Institute of Plant Science and Resources, Okayama University
en-aut-mei=
kn-aut-name=岡山大学資源植物科学研究所
kn-aut-sei=岡山大学資源植物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=132
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=33
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug interaction (47. Combination with general anesthetics)
kn-title=薬物相互作用（47―全身麻酔薬の薬物相互作用）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IgawaYusuke
en-aut-sei=Igawa
en-aut-mei=Yusuke
kn-aut-name=井川祐輔
kn-aut-sei=井川
kn-aut-mei=祐輔
aut-affil-num=1
ORCID=

en-aut-name=EsumiSatoru
en-aut-sei=Esumi
en-aut-mei=Satoru
kn-aut-name=江角悟
kn-aut-sei=江角
kn-aut-mei=悟
aut-affil-num=2
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=北村佳久
kn-aut-sei=北村
kn-aut-mei=佳久
aut-affil-num=3
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=岡山大学病院　薬剤部

affil-num=2
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=岡山大学病院　薬剤部

affil-num=3
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=岡山大学病院　薬剤部

affil-num=4
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=岡山大学病院　薬剤部
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
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dt-received=
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dt-pub-year=2020
dt-pub=20200325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ラットにおけるニューロメジンUの発現制御機構及び生理機能の解析
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=顧??
kn-aut-sei=顧
kn-aut-mei=??
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
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dt-pub-year=2020
dt-pub=20200325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=真菌二次代謝産物(+)-terreinは絹糸結紮歯周炎マウスモデルにおいて炎症性骨吸収を抑制する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SakoHidefumi
en-aut-sei=Sako
en-aut-mei=Hidefumi
kn-aut-name=佐光秀文
kn-aut-sei=佐光
kn-aut-mei=秀文
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
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end-page=
dt-received=
dt-revised=
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dt-pub-year=2020
dt-pub=20200325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=コラーゲン結合型塩基性線維芽細胞増殖因子はその高い組織内滞留性によって効率的に歯周組織再生を促進する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkamotoKentaro
en-aut-sei=Okamoto
en-aut-mei=Kentaro
kn-aut-name=岡本憲太郎
kn-aut-sei=岡本
kn-aut-mei=憲太郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙・目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=109
cd-vols=
no-issue=
article-no=
start-page=49
end-page=4961
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2019.
kn-title=公表学術論文等リスト2019
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=109
cd-vols=
no-issue=
article-no=
start-page=1
end-page=6
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Recombinant expression and characterization of quinone-containing novel glycine oxidase from Marinomonas mediterranea
kn-title=Marinomonas mediterranea由来キノン含有新規グリシンオキシダーゼの大腸菌発現系の確立と性質検討
en-subtitle=
kn-subtitle=
en-abstract=, , , 
kn-abstract= 　Novel glycine oxidase (GlyOX) from Marinomonas mediterranea depends on cysteine tryptophilquinone (CTQ) and catalyzes the oxidative deamination of glycine to produce a glyoxylate, ammonia, and hydrogen peroxide. M. mediterranea GlyOX genes (goxA and goxB) were cloned and recombinant GlyOX was heterologously expressed by E. coli. The purification of recombinant GlyOX was carried out by metal affinity and DEAE-Toyopearl 650M column chromatographies. M. mediterranea GlyOX was homotetramic with a molecular mass of 76kDa and showed optimum activity around 30°C and at pH 5.0, and stability below 50°C and between pH 5.0 to 9.0. M. mediterranea GlyOX shows a strict substrate specificity toward glycine, and the Michaelis constant for glycine was 0.5mM. M. mediterranea GlyOX could determine the quantity of glycine in human serum and human blood plasma with high sensitivity. This study revealed the catalytic and structural properties of M. mediterranea GlyOX with high substrate specificity.
en-copyright=
kn-copyright=

en-aut-name=KajiyamaYuki
en-aut-sei=Kajiyama
en-aut-mei=Yuki
kn-aut-name=梶山雄輝
kn-aut-sei=梶山
kn-aut-mei=雄輝
aut-affil-num=1
ORCID=

en-aut-name=MizobataSatsuki
en-aut-sei=Mizobata
en-aut-mei=Satsuki
kn-aut-name=溝端佐津紀
kn-aut-sei=溝端
kn-aut-mei=佐津紀
aut-affil-num=2
ORCID=

en-aut-name=AkajiShusaku
en-aut-sei=Akaji
en-aut-mei=Shusaku
kn-aut-name=赤地周作
kn-aut-sei=赤地
kn-aut-mei=周作
aut-affil-num=3
ORCID=

en-aut-name=NemotoMichiko
en-aut-sei=Nemoto
en-aut-mei=Michiko
kn-aut-name=根本理子
kn-aut-sei=根本
kn-aut-mei=理子
aut-affil-num=4
ORCID=

en-aut-name=TamuraTakashi
en-aut-sei=Tamura
en-aut-mei=Takashi
kn-aut-name=田村隆
kn-aut-sei=田村
kn-aut-mei=隆
aut-affil-num=5
ORCID=

en-aut-name=InagakiKenji
en-aut-sei=Inagaki
en-aut-mei=Kenji
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
en-keyword=glycine oxidase
kn-keyword=glycine oxidase
en-keyword=Marinomonas mediterranea
kn-keyword=Marinomonas mediterranea
en-keyword=cysteine tryptophilquinone
kn-keyword=cysteine tryptophilquinone
en-keyword=recombinant expression
kn-keyword=recombinant expression
en-keyword=enzymatic glycine assay
kn-keyword=enzymatic glycine assay
END

start-ver=1.4
cd-journal=joma
no-vol=109
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=
article-no=
start-page=2
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The mammalian pigmentary system - a model experimental system for exploring the functional divergence of a differentiated cell type
kn-title=色素細胞系 : 生命機能発現機構解明の１モデルシステム
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= There are two cell lineages of mammalian melanin pigment cells, one that leads to retinal pigment epithelium (RPE) cells in the eye from the optic cup and the other leading to melanocytes from vertebrate-specific neural crest cells. Melanocyte precursors have high mobility and migrate and settle into various tissues and organs, including the skin, choroid, inner ear, heart, brain, adipose tissue, lung, etc. It is well known that RPE cells are essential for visual acuity and that melanocytes in the skin provide protection against UV-damage. So, what is the function of extracutaneous melanocytes that are distributed elsewhere in the body where only very small amounts of light illuminate their existence? Here I would like to briefly introduce our research history and then discuss the important roles of melanocytes in the inner ear that are indispensable for hearing ability and those in the choroid where they seem to contribute to maintaining the structures of their habitats.
en-copyright=
kn-copyright=

en-aut-name=YamamotoHiroaki
en-aut-sei=Yamamoto
en-aut-mei=Hiroaki
kn-aut-name=山本博章
kn-aut-sei=山本
kn-aut-mei=博章
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Faculty of Bioscience Nagahama Institute of Bio-Science and Technology
kn-affil=長浜バイオ大学バイオサイエンス学部
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=クラス�V型ペルオキシダーゼのオキシダティブバースト反応と免疫における役割
kn-title=Role of class III peroxidase PRX34 in plant oxidative burst and immunity 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ZhaoLei
en-aut-sei=Zhao
en-aut-mei=Lei
kn-aut-name=趙磊
kn-aut-sei=趙
kn-aut-mei=磊
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=質量分析による小胞型グルタミン酸トランスポーター２検出法の改良
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KawakamiMamiyo
en-aut-sei=Kawakami
en-aut-mei=Mamiyo
kn-aut-name=河上麻美代
kn-aut-sei=河上
kn-aut-mei=麻美代
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=局所投与されたイバブラジンは過分極活性化環状ヌクレオチド依存性（HCN）チャネルを介してカラゲニンによって誘発された神経障害性疼痛および炎症反応を抑制する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MiyakeSaki
en-aut-sei=Miyake
en-aut-mei=Saki
kn-aut-name=三宅沙紀
kn-aut-sei=三宅
kn-aut-mei=沙紀
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=カイコにおけるMycobacterium ulceransの感染モデルの検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TokuzenHideki
en-aut-sei=Tokuzen
en-aut-mei=Hideki
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kn-aut-sei=徳善
kn-aut-mei=英紀
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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kn-title=コラーゲン結合型塩基性線維芽細胞増殖因子とコラーゲン基剤を用いた複合剤は水平性骨欠損における歯周組織再生を促進する
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kn-copyright=

en-aut-name=NakamuraShin
en-aut-sei=Nakamura
en-aut-mei=Shin
kn-aut-name=中村心
kn-aut-sei=中村
kn-aut-mei=心
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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en-title=SOCS3のリンパ球特異的な過剰発現は、マウスを用いたモデルにおいて、異所性に移植された気管の内腔閉塞を抑制する
kn-title=SOCS3 overexpression in T cells ameliorates chronic airway obstruction in a murine heterotopic tracheal transplantation model　
en-subtitle=
kn-subtitle=
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kn-copyright=

en-aut-name=MesakiKumi
en-aut-sei=Mesaki
en-aut-mei=Kumi
kn-aut-name=目�ｱ久美
kn-aut-sei=目�ｱ
kn-aut-mei=久美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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kn-subject=
en-title=膵癌における葉酸レセプターαの発現と臨床病理学的意義についての検討
kn-title=Overexpression of folate receptor alpha is an independent prognostic factor for outcomes of pancreatic cancer patients 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OmoteShizuma
en-aut-sei=Omote
en-aut-mei=Shizuma
kn-aut-name=表静馬
kn-aut-sei=表
kn-aut-mei=静馬
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

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cd-journal=joma
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dt-pub-year=2018
dt-pub=20181227
dt-online=
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kn-article=
en-subject=
kn-subject=
en-title=ケラチン19陽性肝細胞癌におけるエピジェネティックマーカーおよび上皮間葉転換マーカーの特異性
kn-title=Heterogeneity of Epigenetic and Epithelial Mesenchymal Transition Marks in Hepatocellular Carcinoma with Keratin 19 Proficiency
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YokomichiNaosuke
en-aut-sei=Yokomichi
en-aut-mei=Naosuke
kn-aut-name=横道直佑
kn-aut-sei=横道
kn-aut-mei=直佑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=108
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article-no=
start-page=19
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dt-pub-year=2019
dt-pub=20190201
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2018
kn-title=公表学術論文等リスト 2018
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Faculty of Agriculture, Okayama University
en-aut-sei=Faculty of Agriculture, Okayama University
en-aut-mei=
kn-aut-name=岡山大学農学部
kn-aut-sei=岡山大学農学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
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kn-affil=
END

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dt-pub-year=2018
dt-pub=20180927
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=免疫系においてステルス効果を有するテロメラーゼ特異的腫瘍崩壊性アデノウイルスのリポソーム封入プラスミドDNA
kn-title=Liposome-encapsulated plasmid DNA of telomerase-specific oncolytic adenovirus with stealth effect on the immune system
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AoyamaKatsuyuki
en-aut-sei=Aoyama
en-aut-mei=Katsuyuki
kn-aut-name=青山克幸
kn-aut-sei=青山
kn-aut-mei=克幸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
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dt-received=
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dt-pub-year=2018
dt-pub=20180630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=固形腫瘍におけるDNAミスマッチ修復欠損の同定のための4つのモノヌクレオチドリピートマーカーの正確性
kn-title=Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakeharaYuko
en-aut-sei=Takehara
en-aut-mei=Yuko
kn-aut-name=竹原裕子
kn-aut-sei=竹原
kn-aut-mei=裕子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
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dt-pub-year=2018
dt-pub=20180630
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en-subject=
kn-subject=
en-title=ラットのリンパ浮腫反応モデルにおいて、浅層のリンパ管は増加する
kn-title=Enhancement of lymphatic vessels in the superficial layer in a rat model of a lymphedematous response
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsumotoKumi
en-aut-sei=Matsumoto
en-aut-mei=Kumi
kn-aut-name=松本久美子
kn-aut-sei=松本
kn-aut-mei=久美子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=34
cd-vols=
no-issue=
article-no=
start-page=5
end-page=9
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=201804
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Extracorporeal Excretion of Mercury from Mice Using Molybdenum Complex
kn-title=生体内水銀の体外排泄に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Extracorporeal excretion of mercury by two molybdenum complexes was investigated using mice after injection of metallic mercury or mercuric ion. After injection of metallic mercury into mice, the mice that received the incomplete cubane-type sulfur-bridged nitrilotriacetato molybdenum (IV) complex ([Mo3S4(Hnta)3]2-, referred to as the NTA complex) had the highest mercury content in their urine on the first day, followed by L-cysteine solution and then water. On the other hand, after injection of mercuric ion, the urinary mercury excretion from the mice that received various concentrations of the incomplete cubane-type sulfur-bridged cysteinato molybdenum (V) complex ([Mo2O2S2(cys)2]2-, referred to as the CYS complex) showed a higher level than that of mice that received water (control group). The mercury content in the heart and lungs of the group that received the CYS complex solution decreased in comparison with that of the group that received the water. At the same time, the mercury level in the kidneys for the CYS complex solution group showed the tendency to increase relative to the group that received water.
en-copyright=
kn-copyright=

en-aut-name=AikohHiromi
en-aut-sei=Aikoh
en-aut-mei=Hiromi
kn-aut-name=愛甲博美
kn-aut-sei=愛甲
kn-aut-mei=博美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
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cd-vols=
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article-no=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=好中球における小胞型ヌクレオチドトランスポーターの局在と生理的役割に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HaradaYuika
en-aut-sei=Harada
en-aut-mei=Yuika
kn-aut-name=原田結加
kn-aut-sei=原田
kn-aut-mei=結加
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=High Mobility Group Box 1（HMGB1）誘導性の炎症反応はマウス抜歯窩の骨治癒を促進する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AoyagiHiroaki
en-aut-sei=Aoyagi
en-aut-mei=Hiroaki
kn-aut-name=青柳浩明
kn-aut-sei=青柳
kn-aut-mei=浩明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
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cd-vols=
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article-no=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=腫瘍融解アデノウイルス療法におけるゾレドロン酸の役割 : 抗腫瘍効果の促進と骨破壊の予防
kn-title=Role of zoledronic acid in oncolytic virotherapy : Promotion of antitumor effect and prevention of bone destruction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamakawaYasuaki
en-aut-sei=Yamakawa
en-aut-mei=Yasuaki
kn-aut-name=山川泰明
kn-aut-sei=山川
kn-aut-mei=泰明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=
article-no=
start-page=1
end-page=54
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Annual report, Institute of Plant Science and Resources, Okayama University
kn-title=岡山大学資源植物科学研究所報告24巻
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name= Institute of Plant Science and Resources, Okayama University
en-aut-sei= Institute of Plant Science and Resources, Okayama University
en-aut-mei=
kn-aut-name=岡山大学資源植物科学研究所
kn-aut-sei=岡山大学資源植物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

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article-no=
start-page=
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dt-received=
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dt-pub-year=2017
dt-pub=20171227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=リポポリサッカライド誘発性中耳炎における内耳および中耳におけるマクロファージ遊走阻止因子とCD74の発現
kn-title=Expression of macrophage migration inhibitory factor and CD74 in the inner ear and middle ear in lipopolysaccharide-induced otitis media
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IshiharaHisashi
en-aut-sei=Ishihara
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=107
cd-vols=
no-issue=
article-no=
start-page=25
end-page=39
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2017
kn-title=公表学術論文等リスト　2017
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Faculty of Agriculture, Okayama University
en-aut-sei=Faculty of Agriculture, Okayama University
en-aut-mei=
kn-aut-name=岡山大学農学部
kn-aut-sei=岡山大学農学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

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cd-journal=joma
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cd-vols=
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start-page=
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dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170929
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=小胞型グルタミン酸トランスポーター１スプライシングバリアント(VGLUT1v)の局在と機能に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MoriyamaSatomi
en-aut-sei=Moriyama
en-aut-mei=Satomi
kn-aut-name=森山理美
kn-aut-sei=森山
kn-aut-mei=理美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
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cd-vols=
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dt-received=
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dt-accepted=
dt-pub-year=2017
dt-pub=20170929
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=尿中セマフォリン3Aは微小変化型ネフローゼ症候群の疾患活動性に関連する
kn-title=The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ToriiAkiko
en-aut-sei=Torii
en-aut-mei=Akiko
kn-aut-name=鳥井章子
kn-aut-sei=鳥井
kn-aut-mei=章子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=RUNX3の欠失は、肝細胞癌において5-FUとシスプラチンの抵抗性を誘発する
kn-title=Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KataokaJunro
en-aut-sei=Kataoka
en-aut-mei=Junro
kn-aut-name=片岡淳朗
kn-aut-sei=片岡
kn-aut-mei=淳朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=マウス心筋細胞におけるアンジオテンシン�U１型受容体依存性伸展誘発遅発性細胞内Ca2+濃度上昇にTRPC3が関与している
kn-title=TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamaguchiYohei
en-aut-sei=Yamaguchi
en-aut-mei=Yohei
kn-aut-name=山口陽平
kn-aut-sei=山口
kn-aut-mei=陽平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=放線菌由来L-メチオニン脱炭酸酵素の機能解析と臨床診断への活用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HayashiMasaya
en-aut-sei=Hayashi
en-aut-mei=Masaya
kn-aut-name=林将也
kn-aut-sei=林
kn-aut-mei=将也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of sensitivity to Cetuximab in HNC xenograft mouse models using molecular imaging
kn-title=頭頸部癌マウスモデルを用いた分子イメージングによる抗癌剤セツキシマブ感受性の評価
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OkadaShunsuke
en-aut-sei=Okada
en-aut-mei=Shunsuke
kn-aut-name=岡田俊輔
kn-aut-sei=岡田
kn-aut-mei=俊輔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

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cd-journal=joma
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dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The role of bone marrow-derived cells in ectopic bone regeneration in the GFP mouse bone marrow transplantation model
kn-title=GFP骨髄移植マウスを用いた異所性骨形成における骨髄由来細胞の役割の解明
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=于淞
kn-aut-sei=于
kn-aut-mei=淞
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

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cd-journal=joma
no-vol=
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dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Role of GFP transplanted bone marrow derived cells into tumor stroma
kn-title=GFP骨髄移植マウスを用いた腫瘍間質における骨髄由来細胞の動態と役割
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=河合穂高
kn-aut-sei=河合
kn-aut-mei=穂高
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
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dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=菊池病（組織球性壊死性リンパ節炎）の病理学的な予後予測因子についての検討
kn-title=Kikuchi-Fujimoto disease: evaluation of prognostic factors and analysis of pathologic findings
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MarunakaHidenori
en-aut-sei=Marunaka
en-aut-mei=Hidenori
kn-aut-name=丸中秀格
kn-aut-sei=丸中
kn-aut-mei=秀格
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170324
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ラットくも膜下出血後脳血管攣縮と脳障害に対して抗HMGB-1抗体は有効である
kn-title=Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HarumaJun
en-aut-sei=Haruma
en-aut-mei=Jun
kn-aut-name=春間純
kn-aut-sei=春間
kn-aut-mei=純
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学医歯薬学総合研究科
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=
article-no=
start-page=59
end-page=73
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20170201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2016.
kn-title=公表学術論文等リスト　2016
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Faculty of Agriculture, Okayama University
en-aut-sei=Faculty of Agriculture, Okayama University
en-aut-mei=
kn-aut-name=岡山大学農学部
kn-aut-sei=岡山大学農学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
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end-page=
dt-received=
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dt-pub-year=2016
dt-pub=20160930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=薬物トランスポーターヒトMATE1の機能と分子機構に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KawasakiTatsuya
en-aut-sei=Kawasaki
en-aut-mei=Tatsuya
kn-aut-name=川嵜達也
kn-aut-sei=川嵜
kn-aut-mei=達也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=3
article-no=
start-page=213
end-page=216
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20161201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Probable IgG4-related thyroiditis with cervical lymphadenopathy
kn-title=リンパ節転移を伴う甲状腺癌を疑ったIgG4関連甲状腺炎（準確診群）の1 切除例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　We present a case of probably IgG4-related thyroiditis with lymphadenopathy. The patient was a 70-year-old Japanese female who was undergoing hemodialysis and had undergone a right hemi-thyroidectomy in 1989 due to carcinoma. In December 2010, an ultrasonography study revealed a hypoechoic small lesion in thyroid gland. When the patient was admitted to our hospital in November 2013, the lesion and regional lymph nodes had enlarged and we suspected that they were metastatic thyroid cancer. We performed a residual total thyroidectomy and regional lymph node dissection in August 2014. At that time, lymphoplasmacytic infiltration and fibrosis were observed histopathologically in thyroid tissue. Immunohistochemical studies revealed infiltrated lymphocytes and plasma cells were markedly IgG-positive, and the ratio of IgG4-positive to IgG-positive cells was over 40%. We therefore diagnosed the patient with IgG4-related thyroiditis. The cervical lymph nodes were metastases of papillary carcinoma from 25 years earlier. The patient remains well without any recurrences 33 months after the surgery.
en-copyright=
kn-copyright=

en-aut-name=KobashiKenta
en-aut-sei=Kobashi
en-aut-mei=Kenta
kn-aut-name=小橋研太
kn-aut-sei=小橋
kn-aut-mei=研太
aut-affil-num=1
ORCID=

en-aut-name=IshiiHiroshi
en-aut-sei=Ishii
en-aut-mei=Hiroshi
kn-aut-name=石井博
kn-aut-sei=石井
kn-aut-mei=博
aut-affil-num=2
ORCID=

en-aut-name=NishiyamaKanako
en-aut-sei=Nishiyama
en-aut-mei=Kanako
kn-aut-name=西山加那子
kn-aut-sei=西山
kn-aut-mei=加那子
aut-affil-num=3
ORCID=

en-aut-name=MatsumiYuki
en-aut-sei=Matsumi
en-aut-mei=Yuki
kn-aut-name=松三雄騎
kn-aut-sei=松三
kn-aut-mei=雄騎
aut-affil-num=4
ORCID=

en-aut-name=HatanoMasahide
en-aut-sei=Hatano
en-aut-mei=Masahide
kn-aut-name=羽田野雅英
kn-aut-sei=羽田野
kn-aut-mei=雅英
aut-affil-num=5
ORCID=

en-aut-name=FujiwaraMasamitsu
en-aut-sei=Fujiwara
en-aut-mei=Masamitsu
kn-aut-name=藤原雅光
kn-aut-sei=藤原
kn-aut-mei=雅光
aut-affil-num=6
ORCID=

en-aut-name=KurokawaTatsuo
en-aut-sei=Kurokawa
en-aut-mei=Tatsuo
kn-aut-name=黒河達雄
kn-aut-sei=黒河
kn-aut-mei=達雄
aut-affil-num=7
ORCID=

en-aut-name=TsunemitsuKensuke
en-aut-sei=Tsunemitsu
en-aut-mei=Kensuke
kn-aut-name=常光謙輔
kn-aut-sei=常光
kn-aut-mei=謙輔
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Surgery, Saiseikai Saijo Hospital
kn-affil=済生会西条病院　外科

affil-num=2
en-affil=Department of Surgery, Saiseikai Saijo Hospital
kn-affil=済生会西条病院　外科

affil-num=3
en-affil=Breast Center, Ehime University Hospital
kn-affil=愛媛大学医学部附属病院　乳腺センター

affil-num=4
en-affil=Department of Surgery, Saiseikai Saijo Hospital
kn-affil=済生会西条病院　外科

affil-num=5
en-affil=Department of Surgery, Saiseikai Saijo Hospital
kn-affil=済生会西条病院　外科

affil-num=6
en-affil=Department of Surgery, Imabariishikaishimin Hospital
kn-affil=今治医師会市民病院　外科

affil-num=7
en-affil=Department of Surgery, Saiseikai Saijo Hospital
kn-affil=済生会西条病院　外科

affil-num=8
en-affil=Department of Surgery, Saiseikai Saijo Hospital
kn-affil=済生会西条病院　外科
en-keyword=IgG4 関連甲状腺炎（IgG4-related thyroiditis）
kn-keyword=IgG4 関連甲状腺炎（IgG4-related thyroiditis）
en-keyword=橋本病（Hashimoto’s thyroiditis）
kn-keyword=橋本病（Hashimoto’s thyroiditis）
en-keyword=転移性リンパ節腫瘍（metastatic lymph node tumor）
kn-keyword=転移性リンパ節腫瘍（metastatic lymph node tumor）
en-keyword=慢性腎不全（chronic renal failure）
kn-keyword=慢性腎不全（chronic renal failure）
END

start-ver=1.4
cd-journal=joma
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dt-received=
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dt-accepted=
dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=炎症反応に由来するDNA傷害産物の生成機構解明と食品因子による制御
kn-title=DNA halogenation as potential biomarkers during the early inflammation stage and its regulation by food constituents. 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AsahiTakashi
en-aut-sei=Asahi
en-aut-mei=Takashi
kn-aut-name=朝日尚
kn-aut-sei=朝日
kn-aut-mei=尚
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
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dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=尿酸輸送機構におけるNPT homologue及びNPT3の発現と機能に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TogawaNatsuko
en-aut-sei=Togawa
en-aut-mei=Natsuko
kn-aut-name=外川奈津子
kn-aut-sei=外川
kn-aut-mei=奈津子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=2016
dt-pub=20160325
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kn-subject=
en-title=
kn-title=末梢神経損傷後の侵害受容1次ニューロンの収斂投射
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KishimotoNoriko
en-aut-sei=Kishimoto
en-aut-mei=Noriko
kn-aut-name=岸本宜子
kn-aut-sei=岸本
kn-aut-mei=宜子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-pub-year=2016
dt-pub=20160325
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kn-article=
en-subject=
kn-subject=
en-title=
kn-title=歯槽骨再生を目的としたin vivo electroporation法を用いたラット歯周組織への遺伝子導入
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KataokaYohei
en-aut-sei=Kataoka
en-aut-mei=Yohei
kn-aut-name=片岡陽平
kn-aut-sei=片岡
kn-aut-mei=陽平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
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cd-vols=
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dt-received=
dt-revised=
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dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=神経軸索ガイダンス因子Semaphorin4Dの口腔癌骨浸潤に果たす役割に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakadaHiroyuki
en-aut-sei=Takada
en-aut-mei=Hiroyuki
kn-aut-name=高田紘行
kn-aut-sei=高田
kn-aut-mei=紘行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=High mobility group box 1の歯周炎惹起および遷延化のメカニズムに関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YoshiharaChiaki
en-aut-sei=Yoshihara
en-aut-mei=Chiaki
kn-aut-name=吉原千暁　
kn-aut-sei=吉原
kn-aut-mei=千暁　
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ゾレドロン酸が歯周炎に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=IdeguchiHidetaka
en-aut-sei=Ideguchi
en-aut-mei=Hidetaka
kn-aut-name=井手口英隆
kn-aut-sei=井手口
kn-aut-mei=英隆
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=
article-no=
start-page=41
end-page=52
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2015.
kn-title=公表学術論文等リスト　2015
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学農学部
kn-aut-sei=岡山大学農学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=糖尿病診断用マーカー1,5-アンヒドロ-D-グルシトールを基質とするソルボース脱水素酵素とピラノース酸化酵素の機能解析と応用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ArakiToshio
en-aut-sei=Araki
en-aut-mei=Toshio
kn-aut-name=荒木俊雄
kn-aut-sei=荒木
kn-aut-mei=俊雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
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article-no=
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dt-received=
dt-revised=
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dt-pub-year=2015
dt-pub=20150325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Lactobacillus属細菌の環境適応能の解析とその応用に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=WatanabeMasayuki
en-aut-sei=Watanabe
en-aut-mei=Masayuki
kn-aut-name=渡邊正行
kn-aut-sei=渡邊
kn-aut-mei=正行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=
article-no=
start-page=61
end-page=73
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2014.
kn-title=公表学術論文等リスト　2014
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学農学部
kn-aut-sei=岡山大学農学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=
article-no=
start-page=1
end-page=4
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20150201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Improvement of dye-mediated dehydrogenase activity of pyranose oxidase by site-directed mutagenesis
kn-title=部位特異的変異によるピラノース酸化酵素の色素依存性脱水素酵素活性の向上
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　Pyranose oxidase (EC 1.1.3.10 ; PROD) catalyzes the oxidation of aldopyranoses at the position C?2
to yield the corresponding 2?keto-aldoses and H2O2 , using oxygen as an electron acceptor. The enzyme shows broad substrate specificity as well as reactivity for 1,5?anhydro?d?glucitol (1,5?AG), which is known as a clinical glycemic marker. It is considered that the reactivity of PROD for 1,5?AG is useful in the development of an amperometric-type biosensor, which is a convenient diagnostic device for selfmonitoring
blood glucose (SMBG). However, the levels of dissolved oxygen in blood affect biosensor
systems that are equipped with an artificial electron mediator. In the present study, we attempted to develop an O2?insensitive oxidase that would improve the dye-mediated dehydrogenase activity. We performed site-directed mutagenesis on PROD isolated from basidiomycetous fungus No. 52, which generated 11 mutants. The amino acid substitution Q421A exhibited a significant decrease (8.8% of wild type) in its oxidase activity, whereas it maintained its dehydrogenase activity (67% of wild type). In this study, we characterized PROD mutants from basidiomycetous fungus No. 52, which showed improved dye-mediated dehydrogenase activity.
en-copyright=
kn-copyright=

en-aut-name=ArakiToshio
en-aut-sei=Araki
en-aut-mei=Toshio
kn-aut-name=荒木俊雄
kn-aut-sei=荒木
kn-aut-mei=俊雄
aut-affil-num=1
ORCID=

en-aut-name=NakatsukaTomoko
en-aut-sei=Nakatsuka
en-aut-mei=Tomoko
kn-aut-name=中柄朋子
kn-aut-sei=中柄
kn-aut-mei=朋子
aut-affil-num=2
ORCID=

en-aut-name=TamuraTakashi
en-aut-sei=Tamura
en-aut-mei=Takashi
kn-aut-name=田村隆
kn-aut-sei=田村
kn-aut-mei=隆
aut-affil-num=3
ORCID=

en-aut-name=InagakiKenji
en-aut-sei=Inagaki
en-aut-mei=Kenji
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=池田食研株式会社

affil-num=2
en-affil=
kn-affil=池田食研株式会社

affil-num=3
en-affil=
kn-affil=岡山大学農学部

affil-num=4
en-affil=
kn-affil=岡山大学農学部
en-keyword=pyranose oxidase
kn-keyword=pyranose oxidase
en-keyword=1,5-anhydro-d-glucitol
kn-keyword=1,5-anhydro-d-glucitol
en-keyword=biosensor
kn-keyword=biosensor
en-keyword=site-directed mutagenesis
kn-keyword=site-directed mutagenesis
en-keyword=SMBG
kn-keyword=SMBG
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=199507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=80年の歴史から21世紀へ向けて : 研究活動と学術的・社会的貢献 : 岡山大学資源生物科学研究所創設80周年記念
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1996
dt-pub=1996
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=資源生物科学研究所年報No.3
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=1994
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=資源生物科学研究所年報No.2
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=1
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=1992
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=資源生物科学研究所年報No.1
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=
article-no=
start-page=1
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Annual Report 2007 / Research Institute for Bioresources, Okayama University
kn-title=岡山大学資源生物科学研究所報告15巻
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Research Institute for Bioresources, Okayama University
en-aut-sei=Research Institute for Bioresources, Okayama University
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=
article-no=
start-page=1
end-page=50
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Annual Report 2006 / Research Institute for Bioresources, Okayama University
kn-title=岡山大学資源生物科学研究所報告14巻
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Research Institute for Bioresources, Okayama University
en-aut-sei=Research Institute for Bioresources, Okayama University
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2005
dt-pub=2005
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学資源生物科学研究所報告13巻
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Research Institute for Bioresources, Okayama University
en-aut-sei=Research Institute for Bioresources, Okayama University
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2002
dt-pub=2002
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学資源生物科学研究所報告10巻
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2001
dt-pub=2001
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学資源生物科学研究所報告9巻
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2000
dt-pub=2000
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学資源生物科学研究所報告8巻
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学資源生物科学研究所
kn-aut-sei=岡山大学資源生物科学研究所
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=ラドン吸入が酸化ストレス関連疾患モデルマウスに及ぼす抗酸化・抗炎症作用に関する研究 第１編 ラドン吸入によるストレプトゾトシン誘導マウス１型糖尿病の抑制 第２編 ラドン吸入によるデキストラン硫酸ナトリウム誘導マウス大腸炎の抑制
kn-title=Study on anti-oxidative and anti-inflammatory effects of radon inhalation on mouse models of oxidative stress-related disease 第１編　Suppression of streptozotocin-induced type-1 diabetes in mice by radon inhalation 第２編　Suppression of dextran sulfate sodium-induced colitis in mice by radon inhalation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NishiyamaYuichi
en-aut-sei=Nishiyama
en-aut-mei=Yuichi
kn-aut-name=西山祐一
kn-aut-sei=西山
kn-aut-mei=祐一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=マウスの配偶子形成に関与する遺伝子の機能に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KajitaShinpei
en-aut-sei=Kajita
en-aut-mei=Shinpei
kn-aut-name=梶田晋平
kn-aut-sei=梶田
kn-aut-mei=晋平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=
article-no=
start-page=45
end-page=59
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2013.
kn-title=公表学術論文等リスト　2013
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学農学部
kn-aut-sei=岡山大学農学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=
article-no=
start-page=5
end-page=9
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Characterization of L-Arginine Oxidase Made from L-Glutamate Oxidase
kn-title=高基質特異性L-グルタミン酸オキシダーゼより作成した基質特異性改変酵素L-アルギニンオキシダーゼの性質検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　L?Glutamate oxidase (LGOX) from Streptomyces sp. X?119?6 has strict substrate specificity toward
L?glutamate. Recently, we solved the X?ray crystal structure of LGOX and this revealed that Arg305 in
the active site is the key residue involved in substrate recognition. Therefore, we created 19 mutant
enzymes of R305X?LGOX by saturation mutagenesis. One of them R305D?LGOX, Arg305 substituted
with Asp exhibited oxidase activity for L?Arg. Optimum pH of R305D?LGOX mutant enzyme was pH
8.5. Interestingly, the activity of R305D?LGOX toward L?Arg was inhibited by phosphate. And furthermore,
the substrate specificity of R305D?LGOX was affected by using buffer. The results of inhibition
analysis suggest, that phosphate is a competitive inhibitor of R305D?LGOX when L?Arg is used as
substrate. Kinetic analysis of R305D?LGOX showed that Km value and kcat value of R305D?LGOX toward
l-Arg were 0.68 mM and 6.7 s-1 respectively. In this study, we showed that R305D?LGOX mutant
enzyme is a novel l-arginine oxidase and useful for l-arginine biosensor.
en-copyright=
kn-copyright=

en-aut-name=NakaiRyuichiro
en-aut-sei=Nakai
en-aut-mei=Ryuichiro
kn-aut-name=中井隆一郎
kn-aut-sei=中井
kn-aut-mei=隆一郎
aut-affil-num=1
ORCID=

en-aut-name=FujinoShihoko
en-aut-sei=Fujino
en-aut-mei=Shihoko
kn-aut-name=藤野志保子
kn-aut-sei=藤野
kn-aut-mei=志保子
aut-affil-num=2
ORCID=

en-aut-name=UtsumiTomohiro
en-aut-sei=Utsumi
en-aut-mei=Tomohiro
kn-aut-name=内海友宏
kn-aut-sei=内海
kn-aut-mei=友宏
aut-affil-num=3
ORCID=

en-aut-name=TamuraTakashi
en-aut-sei=Tamura
en-aut-mei=Takashi
kn-aut-name=田村隆
kn-aut-sei=田村
kn-aut-mei=隆
aut-affil-num=4
ORCID=

en-aut-name=KusakabeaHitoshi
en-aut-sei=Kusakabea
en-aut-mei=Hitoshi
kn-aut-name=日下部均
kn-aut-sei=日下部
kn-aut-mei=均
aut-affil-num=5
ORCID=

en-aut-name=InagakiKenji
en-aut-sei=Inagaki
en-aut-mei=Kenji
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学

affil-num=5
en-affil=
kn-affil=�潟Gンザイムセンサ

affil-num=6
en-affil=
kn-affil=岡山大学
en-keyword=L-glutamate oxidase
kn-keyword=L-glutamate oxidase
en-keyword=L-arginine oxidase
kn-keyword=L-arginine oxidase
en-keyword=biosensor
kn-keyword=biosensor
en-keyword=modified substrate specificity
kn-keyword=modified substrate specificity
en-keyword=L-amino acid oxidase
kn-keyword=L-amino acid oxidase
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2014
dt-pub=20140201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学農学部
kn-aut-sei=岡山大学農学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=1
article-no=
start-page=37
end-page=55
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19810225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Multiple forms of α-glucosidase with different substrate specificities from plant seeds
kn-title=種々の種子からの基質特異性が異なる多型のα-グルコシダーゼ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SuzukiY.
en-aut-sei=Suzuki
en-aut-mei=Y.
kn-aut-name=鈴木幸雄
kn-aut-sei=鈴木
kn-aut-mei=幸雄
aut-affil-num=1
ORCID=

en-aut-name=YamasakiY.
en-aut-sei=Yamasaki
en-aut-mei=Y.
kn-aut-name=山崎良樹
kn-aut-sei=山崎
kn-aut-mei=良樹
aut-affil-num=2
ORCID=

en-aut-name=UchidaK.
en-aut-sei=Uchida
en-aut-mei=K.
kn-aut-name=内田絅
kn-aut-sei=内田
kn-aut-mei=絅
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=

affil-num=3
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=60
cd-vols=
no-issue=2
article-no=
start-page=81
end-page=89
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=198302
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Formation of glucosylriboflavin from riboflavin in germinating barley seeds
kn-title=ハダカムギの発芽種子におけるリボフラビンからグルコシルリボフラビンの生成
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SuzukiY.
en-aut-sei=Suzuki
en-aut-mei=Y.
kn-aut-name=鈴木幸雄
kn-aut-sei=鈴木
kn-aut-mei=幸雄
aut-affil-num=1
ORCID=

en-aut-name=UchidaK.
en-aut-sei=Uchida
en-aut-mei=K.
kn-aut-name=内田絅
kn-aut-sei=内田
kn-aut-mei=絅
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=2
article-no=
start-page=73
end-page=86
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=197803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Physiological and ecological studies on ethylene in crop plants. II. Studies on the growth and physiology of rice plants as affected by water stress in relation to ethylene
kn-title=作物におけるエチレンの生理,生態的研究 II. 水分ストレスが水稻の生育,生理に及ぼす影響ならびにそのエチレンとの関係
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=BabaI.
en-aut-sei=Baba
en-aut-mei=I.
kn-aut-name=馬場赳
kn-aut-sei=馬場
kn-aut-mei=赳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

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cd-journal=joma
no-vol=17
cd-vols=
no-issue=
article-no=
start-page=77
end-page=92
dt-received=
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dt-accepted=
dt-pub-year=1931
dt-pub=19310705
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=��米に就きての研究 第二報
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=近藤萬太郎
kn-aut-sei=近藤
kn-aut-mei=萬太郎
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡村保
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ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
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END

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cd-journal=joma
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dt-received=
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dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=
kn-title=Npr2遺伝子の突然変異によりC型ナトリウム利尿ペプチド受容体の機能が欠損したSLWマウスに関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SogawaChiduru
en-aut-sei=Sogawa
en-aut-mei=Chiduru
kn-aut-name=曽川千鶴
kn-aut-sei=曽川
kn-aut-mei=千鶴
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
no-vol=
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dt-pub-year=2013
dt-pub=20130325
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kn-subject=
en-title=
kn-title=GGT1欠損モデルとしてのDWGマウスを用いた生殖機能におけるGGT1の役割に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=

en-aut-name=YamadaKaoru
en-aut-sei=Yamada
en-aut-mei=Kaoru
kn-aut-name=山田郁
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kn-aut-mei=郁
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-pub-year=2013
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kn-title=ラット大脳皮質咀嚼野の電気刺激が誘発するリズミカルな顎運動と唾液分泌の関連
en-subtitle=
kn-subtitle=
en-abstract=
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kn-copyright=

en-aut-name=MaedaNaoto
en-aut-sei=Maeda
en-aut-mei=Naoto
kn-aut-name=前田直人
kn-aut-sei=前田
kn-aut-mei=直人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
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dt-pub-year=2013
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en-title=
kn-title=骨折治癒過程におけるFocal adhesion kinaseを介したSonic hedgehog の役割
en-subtitle=
kn-subtitle=
en-abstract=
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en-copyright=
kn-copyright=

en-aut-name=HorikiriYU
en-aut-sei=Horikiri
en-aut-mei=YU
kn-aut-name=堀切優
kn-aut-sei=堀切
kn-aut-mei=優
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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cd-journal=joma
no-vol=
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dt-received=
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dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
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en-subject=
kn-subject=
en-title=
kn-title=ニコチンが口腔癌の増殖およびリンパ節転移に与える影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
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kn-copyright=

en-aut-name=KodamaShinichi
en-aut-sei=Kodama
en-aut-mei=Shinichi
kn-aut-name=兒玉真一
kn-aut-sei=兒玉
kn-aut-mei=真一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

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dt-pub-year=2013
dt-pub=20130325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=末梢神経損傷後の中枢神経における1次ニューロンの収斂投射の研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OmuraSinji
en-aut-sei=Omura
en-aut-mei=Sinji
kn-aut-name=大村晋司
kn-aut-sei=大村
kn-aut-mei=晋司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=125
cd-vols=
no-issue=1
article-no=
start-page=73
end-page=75
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug interaction(26. combination with therapeutic drugs used to treat hyperuricemia)
kn-title=薬物相互作用(26―高尿酸血症治療薬の薬物相互作用）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MakitaTakashi
en-aut-sei=Makita
en-aut-mei=Takashi
kn-aut-name=槇田崇志
kn-aut-sei=槇田
kn-aut-mei=崇志
aut-affil-num=1
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=北村佳久
kn-aut-sei=北村
kn-aut-mei=佳久
aut-affil-num=2
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=2
en-affil=
kn-affil=岡山大学病院　薬剤部

affil-num=3
en-affil=
kn-affil=岡山大学病院　薬剤部
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=シロイヌナズナにおけるメチルグリオキザールの機能
kn-title=Functions of methylglyoxal in Arabidopsis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Sharmin HoqueTahsina
en-aut-sei=Sharmin Hoque
en-aut-mei=Tahsina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120323
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=シロイヌナズナのセレニウム耐性機構における硫酸輸送体の役割
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OhnoMisao
en-aut-sei=Ohno
en-aut-mei=Misao
kn-aut-name=大野美佐緒
kn-aut-sei=大野
kn-aut-mei=美佐緒
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=大腸菌ATP合成酵素におけるスト-ク領域の構造と機能
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=澤田研
kn-aut-sei=澤田
kn-aut-mei=研
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=124
cd-vols=
no-issue=1
article-no=
start-page=15
end-page=26
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hypoglycemic activity of Momordica charantia (bitter melon)
kn-title=ニガウリ抽出物の血糖降下作用に関する文献的考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Diabetes mellitus (DM) represents a global health and economical problem. Many patients with DM in Asia, South America, India and East Africa have traditionally used the water extract of unripe fruits of Momordica charantia (bitter melon) as some form of complementary and alternative medicine. Studies of laboratory animals have shown the beneficial blood-glucose lowering and anti-diabetic effects of this remedy. Some oral components that bring lower blood glucose level have been isolated : charantin (sterol glycosides), charantin (polypeptide) and cucurbine-type triterpenes. Part of their actions are related to AMP-activated kinase and repression of the oxidative stress that is increased in DM. Most clinical reports are not fully convincing due to the lack of randomized control studies. The present article reviews the pharmacological and clinical effects of bitter melon with special emphasis on the anti-diabetic effects, and some effects that would require caution in the context of human trials.
en-copyright=
kn-copyright=

en-aut-name=MankuraMitsumasa
en-aut-sei=Mankura
en-aut-mei=Mitsumasa
kn-aut-name=万倉三正
kn-aut-sei=万倉
kn-aut-mei=三正
aut-affil-num=1
ORCID=

en-aut-name=NodaYasuko
en-aut-sei=Noda
en-aut-mei=Yasuko
kn-aut-name=野田泰子
kn-aut-sei=野田
kn-aut-mei=泰子
aut-affil-num=2
ORCID=

en-aut-name=MoriAkitane
en-aut-sei=Mori
en-aut-mei=Akitane
kn-aut-name=森昭胤
kn-aut-sei=森
kn-aut-mei=昭胤
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　医療薬学・先端薬物療法開発学

affil-num=2
en-affil=
kn-affil=岡山大学医学部　病原細菌学

affil-num=3
en-affil=
kn-affil=岡山大学
en-keyword=ニガウリ (bitter melon)
kn-keyword=ニガウリ (bitter melon)
en-keyword=Momordica charantia
kn-keyword=Momordica charantia
en-keyword=糖尿病 (diabetes mellitus)
kn-keyword=糖尿病 (diabetes mellitus)
en-keyword=酸化ストレス (oxidative stress)
kn-keyword=酸化ストレス (oxidative stress)
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=
article-no=
start-page=71
end-page=83
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Published by Members of the Faculty From January to December 2011
kn-title=公表学術論文等リスト 2011
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学農学部
kn-aut-sei=岡山大学農学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=
article-no=
start-page=49
end-page=64
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Application of continuous light in a plant factory system 4. Physiological changes and concept of injury induction in plant leaves under continuous light
kn-title=閉鎖型植物工場における連続光の利用（第4報）連続光下における植物の生理学的変化ならびに障害誘発の概念
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Physiological changes and concept of injury induction occurring under continuous light are comprehensively reviewed. Continuous light usually reduces photosynthetic rate, which may relate to changes in transpiration and leaf necrosis caused by reactive oxygen species. Other factors apart from photosynthesis may also affect leaf injuries occurring under continuous light. Continuous light sometimes increases carbohydrate and some secondary metabolite contents.
en-copyright=
kn-copyright=

en-aut-name=HataNaoki
en-aut-sei=Hata
en-aut-mei=Naoki
kn-aut-name=畑直樹
kn-aut-sei=畑
kn-aut-mei=直樹
aut-affil-num=1
ORCID=

en-aut-name=MasudaMasaharu
en-aut-sei=Masuda
en-aut-mei=Masaharu
kn-aut-name=桝田正治
kn-aut-sei=桝田
kn-aut-mei=正治
aut-affil-num=2
ORCID=

en-aut-name=MurakamiKenji
en-aut-sei=Murakami
en-aut-mei=Kenji
kn-aut-name=村上賢治
kn-aut-sei=村上
kn-aut-mei=賢治
aut-affil-num=3
ORCID=

en-aut-name=KobayashiAkio
en-aut-sei=Kobayashi
en-aut-mei=Akio
kn-aut-name=小林昭雄
kn-aut-sei=小林
kn-aut-mei=昭雄
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=2
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=3
en-affil=
kn-affil=岡山大学大学院自然科学研究科

affil-num=4
en-affil=
kn-affil=大阪大学大学院工学研究科
en-keyword=carbohydrates
kn-keyword=carbohydrates
en-keyword=circadian rhythm
kn-keyword=circadian rhythm
en-keyword=ethylene
kn-keyword=ethylene
en-keyword=photosynthesis
kn-keyword=photosynthesis
en-keyword=reactive oxygen species
kn-keyword=reactive oxygen species
en-keyword=secondary metabolites
kn-keyword=secondary metabolites
END

start-ver=1.4
cd-journal=joma
no-vol=39
cd-vols=
no-issue=447
article-no=
start-page=446
end-page=454
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1927
dt-pub=19270430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=神經系統ノ「インドフェニールオキシダーゼ」反應知見補遺
kn-title=Beitr?ge zur Kenntnis der Indophenoloxydasereaktion des Nervensystems
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=動物體ノ「オキシダーゼ」反應ニ就イテハEhrlich氏以來多數ノ人々ニ依リ種々ノ方法ヲ以テ檢査セラレタリシガ神經系統ノ「オキシダーゼ」反應ニ關シテハEhrlich氏ハ腦ニ於テAbelous及ビBiarn?s氏ハ腦ニ於テVernon氏ハ腦延髓及ビ小腦ニ於テIndopbenolblausyntheseヲ觀察シ只漠然ト其ノ陽性ナルカ陰性ナルカヲ述べ微細ナル點ニハ更ニ言及セズ. 又多クノ學者Slozon, Rosell, Kliopfer,藤原,池田其ノ他ハ神經系統ニハ「オキシダーゼ」ノ存在ヲ否定セリ. 然ルニG?ff氏ハ神經組織ニ「オキシダーゼ」反應陽性ナル部分アルコトヲ主張シ殊ニ神經節細胞ニハ非常ニ多數ノ「オキシダーゼ」顆粒アルコトヲ證明セリ.然レドモ其ノ「オキシダーゼ」顆粒ノ微細ナル分布状態ニ關シテハ論及スルトコロナカリキ,勝沼博士ハ1915年v. Gierke氏法ヲ模倣シテ神經系統ノ「オキシダーゼ」反應ヲ精細ニ檢査シテ「オキシダーゼ」顆粒ノ分市状態ヲ詳細ニ記載セラレタリ. 1916年D?ring氏ハ病理解屍體ノ新鮮ナル材料ヲ用ヒテ中樞神經節細胞ノ「オキシダーゼ」反應竝ニ其ノ意義ニ就イテ研究セリ. 1922年Kappers氏ハ魚類ノ腦ヲ用ヒテ其ノ神經節細胞ノ「オキシダーゼ」反應ヲ檢査セリ. 予モ亦本間題ニ就イテ上坂教授指導ノ下ニ詳細ナル檢査ヲ行ヘリ. 使用セル動物ハ家兎, 犬, 鼠ニシテv. Gierke氏法ヲ模倣シテ0.025%ノα-NaphtholトDimethylparaphenylendiaminトノ食鹽水溶液ヲ用ヒタリ. 檢査ノ結果次ノ如キ結論ヲ得タリ. 予ノ行ヘル檢査ノ成績ハ大體ニ於テ勝沼博士ノソレト大同小異ナリ. 中樞神經ノ灰白質ニ於テハ最初一般ニ瀰漫性ニ青染シヤガテ神經節細胞ニー致シテ著明ナル青色顆粒表ハル. 神經細胞核ハ本反應一般ニ陰性ニシテ微細ナル「インドフェノール」顆粒ヲ以テ充タサレタル細胞體ヨリ明カニ區別スル事ヲ得. 但シ小腦プルキンエ氏細胞,脊髓神經節細胞ハ例外ニシテ核小體ニ「オキシダーゼ」顆粒テ認メ得ルコトアリ. 尚ホ又脊髓前角ニ存スル運動神經細胞ハ其ノ核小體ハ多クノ場合極メテ微細ナル青色顆粒ヲ以テ充タサレタルヲ見タリ. 神經細胞ノ細胞體竝ニ其ノ樹枝状突起ハ微細ナル極メテ多數ノ「オキシグーゼ」顆粒ニテ充タサル之ニ反シ神經突起ニハ極メテ少數ノ青色顆粒存ス. 而モ一度青染セル切片ヲ室温中ニ放置スルニ神經突起ニ存スル青色顆粒ハ樹枝状突起ニ存スルモノヨリハ速ニ消失ス. 運動核ト知覺核トニヨリテハ「オキシグーゼ」反應ニハ差異ナキモノノ如シ, 然レドモ下橄欖ニ於テハ他ノ神經核ニ比シ其ノ「オキシダーゼ」顆粒ハ形稍大ニシテ其ノ數少キモノノ如シ. 中樞神經灰白質ハ全然「オキシダーゼ」反應陰性ナリ. 脊髓神經節ニ在リテハ同一種ノ細胞ト雖モ同樣ノ「オキシダーゼ」反應ヲ呈スルコトナク其ノ度極メテ種々ナリ. 強ク陽性ニ表ハルルモノハ多數ノ青色顆粒ヲ以テ其ノ細胞ヲ充タサルルニ反シ陽性ノ度弱キモノハ只核ノ周圍ニノミ極少數ノ「オキシグーゼ」顆粒存スルノミナリ. 斯ク種々ノ程度ニ染マリタル細胞ハ何等ノ配列ノ順序ナク不規則ニ混在ス. 中樞部ニ存在スル神經終末ハ三叉神經知覺繊維ニ就イテ檢スルニ「オキシダーゼ」反應陰性ナルモノノ如シ.
 軸索ハ其ノ中樞神經細胞ヲ出テ極メテ僅カノ經過竝ニ末梢部終末ヲ除クノ外凡テ本反應陰性ナリ. Piamaterハ微ニ本反應陽性ナレドモ, 夫レガ神經繊維ト交叉シテ夫レヲ中樞部ト末梢部トニ區分スル部分ニアリテハ「オキシダーゼ」反應ハ全ク陰性ナルモノノ如シ.
en-copyright=
kn-copyright=

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en-aut-sei=Kumagai
en-aut-mei=Kuranosuke
kn-aut-name=熊谷藏之允
kn-aut-sei=熊谷
kn-aut-mei=藏之允
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=anatomischen Institut der Universit?t Okayama
END

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cd-journal=joma
no-vol=40
cd-vols=
no-issue=8
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start-page=1813
end-page=1816
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dt-revised=
dt-accepted=
dt-pub-year=1928
dt-pub=19280831
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kn-subject=
en-title=
kn-title=雜報
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kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山医学会
kn-aut-sei=岡山医学会
kn-aut-mei=
aut-affil-num=1
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affil-num=1
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kn-affil=
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cd-journal=joma
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article-no=
start-page=1038
end-page=1042
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dt-revised=
dt-accepted=
dt-pub-year=1928
dt-pub=19280531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber die Oxdasereaktion von Spiroch?ten
kn-title=「スピロヘータ」ノ「オキシダーゼ」反應
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ich habe die Indophenolreaktion bei Spirochaeta pallida, recurrens und morsusmuris gepr?ft. Aber diese Reaktion fiel bei allen Spiroch?ten negativ aus. Auch nach dem Verfahren konnte ich im Dunkelfeld nicht gef?rbte Spiroch?ten konstatieren.
en-copyright=
kn-copyright=

en-aut-name=MurayamaIseo
en-aut-sei=Murayama
en-aut-mei=Iseo
kn-aut-name=村山五瀬男
kn-aut-sei=村山
kn-aut-mei=五瀬男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=8
article-no=
start-page=1864
end-page=1871
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1930
dt-pub=19300831
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber das Studium des Koliantivirus (III. Mitteilung.) ?ber die Immunit?tsreaktion (I.)
kn-title=大腸菌「アンチヴイルス」ノ研究(III) 其ノ免疫學的關係 其ノ1
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1. Im Gegensatz zu der Untersuchung in vitro hat der Koliantivirus bei dem Peritonealversuch eine l?hmende Wirkung auf die Bewegung der Kolibazillen, und zwar treten die Leukozytose und die Aufl?sung der Bakterien auffallend st?rker als bei der Kotrolle auf. 2. Bei den mit dem Koliantivirus vorbereiteten Tieren tritt die l?hmende Wirkung der Kolibazillen beim Peritonealversuch noch deutlicher als bei den nicht behandelten auf, und ausser der st?rkeren Aufl?sung der Bakterien, Leukozytose und Phagozytose ist die bedeutende Vermehrung der ausgewanderten, grossen, mononukle?ren, wahrscheinlich histiozyt?ren Zellen bemerkenswert. 3. Durch nur zweimalige intraperitoneale Injektion des Kaliantivirus wird dem Meerschweinchen eine sch?tzende Kraft gegen die peritoneale Infektion der Minimaldosis der Kolibazillen gegeben. Daraus kann man schliessen, dass der Koliantivirus eine antigene Eigenschaft hat, trotzdem sie von Besredka nicht angenommen wird. 4. Infolgedessen k?nnte man annehmen, dass der Antivirus einen adaequeten Reiz auf den Zellapparat der Bauchh?hle aus?bt und sowohl die Sekretion der die Bakterien aufl?senden Substanz, als auch die Phagozytose unterst?tzt.
en-copyright=
kn-copyright=

en-aut-name=NishiyamaItsuhei
en-aut-sei=Nishiyama
en-aut-mei=Itsuhei
kn-aut-name=西山逸平
kn-aut-sei=西山
kn-aut-mei=逸平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=6
article-no=
start-page=1308
end-page=1337
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1930
dt-pub=19300630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber die Oxydasereaktion von Eiterzellen
kn-title=膿球ノ「オキシダーゼ」反應ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Die Oxydasereaktion von Eiterzellen zeigt sowohl bei den mit Formalindampf fixierten, als auch bei den frischen Ausstrichpr?paraten das gleiche Bild. Die fixierten Pr?parate weisen jedoch im allgemeinen ein deutlicheres Bild auf als die frischen Pr?parate. Daher kann man behaupten, dass die Oxydasereaktion der Eiterzellen stabil ist. Was ihre Widerstandsf?higkeit gegen verschiedene physikalische- u. chemische Vorbehandlungen anbelangt, so zeigt sich diese in folgender Weise: (S. Tabelle 1 im Text) Methylalkohol hebt die Reaktion fast vollkommen auf, dagegen weisen ?thylalkohol, Hepthylalkohol, ?ther, Chloroform und Xylol keine ung?nstige oder nur eine sehr leichte Beeinflussung auf. Cyaukali zeigt erst bei einer relativ hohen Konzentration (5%) eine leichte Sch?digung. Unter den S?uren haben Minerals?uren eine ziemlich deutliche Beeinflunsung, jedoch organische S?uren (Tannin-, Essigs?ure etc.) keine Sch?digungen zur Folge. Alkali zeigt eine schw?chere Einwirkung als Minerals?ure. Die Temperaturwirkung ist bei trocknem Zustand und bei Einlegen in Wasser verschieden, so dass die Reaktion im letzteren Falle schon bei 80°C negativ ausf?llt, w?hrend sie im ersteren selbst bei 100°C noch deutlich erhalten bleibt. Gegen Gasflamme sind fixierte Pr?parate ziemlich stark widerstandsf?hig, dagegen werden frische Pr?parate stark gest?rt. Gegen niedrige Temperaturen besitzt die Reaktion eine starke Widerstandsf?higkeit, sie zeigt n?mlich auch noch bei -20°C fast keine St?rung. Wenn man die Pr?parate den Sonnenstrahlen aussetzt, wird die Reakti?n bei trocknem Zustand niemals, aber bei Einlegen im Wasser erheblich beeinflusst. Nach der Bestrahlung mit ultravioletten Strahlen und R?ntgenstrahlen zeigt sie fast keie merkliche Ver?nderung. Aber die mit Wasser getr?nkten Pr?parate geben etwas schlechtere Ergebnisse als die trockenen. Beim Einlegen der Pr?parate in Formalindampf, Formalinl?sung und in der freien Luft f?llt die Reaktion ziemlich lange positiv aus. Die in Formalindampf eingelegten Pr?parate zeigeu die Reaktion am l?ngsten, und zwar bleibt die Reagierbarkeit selbst nach 1/2 Jahr langer Aufbewahrung im Dampf noch unver?ndert erhalten. Unter den verschiedenen Formalinl?sungen bewirkt saure L?sung der Reaktion eine gr?ssere Sch?digung als die neutrale L?sung. Die Wirkung der Metallsalze ist verschiedenartig. Viele Metallverbindungen (Chrom, Magnesium, Zink, Wismut, Blei, Aluminium, Calcium, Barium, Strontium, Natrium, Kalium, Ammonium etc) haben auf die Reaktion zwar keine spezifische Wirkung, Quecksilber, Zinn etc. jedoch in alien F?llen einen sch?digenden Einfiluss. Dagegen lassen Gold-, Silber-, Kupfer-, Maugan-, Nickel-, Kobalt- und Platinverbindungen die durch Salzs?ure oder Natronlauge einmal negativ gewordene Reaktion wieder zum Vorschein kommen, wenn man noch einmal die Oxydasereaktion probiert. Also reaktivieren die Metallsalze der I., VII und VIII. Gruppe des periodischen Gesetzes die Oxydasereaktion.
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kn-copyright=

en-aut-name=UchidaShigeo
en-aut-sei=Uchida
en-aut-mei=Shigeo
kn-aut-name=内田茂雄
kn-aut-sei=内田
kn-aut-mei=茂雄
aut-affil-num=1
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affil-num=1
en-affil=
kn-affil=岡山醫科大學皮膚科泌尿器科教室
END

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cd-journal=joma
no-vol=25
cd-vols=
no-issue=
article-no=
start-page=42
end-page=49
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Biochemical and histological effects of heat stress on experimental animals
kn-title=暑熱ストレスによる実験動物の生化学的ならびに組織学的変化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=暑熱環境が生体の生化学的変化に及ぼす影響について検討した。暑熱影響を生化学的観点からみると､肝臓における酸素ラジカルの生成が注目される。酸素ラジカルによる生体高分子との反応による脂質過酸化は生体膜や酵素の変性に結びつくため重要な障害反応と考えられるためである。ラット肝臓の脂質過酸化反応生成物の指標であるチオバルビツール酸反応生成物(TBARS)の濃度変化をみると､30℃では変化がなかった生成も､35℃の暑熱負荷では急激に増加した。ラットとモルモットを比較すると､モルモットは30℃においても若干の増加が認められ､35℃では顕著な増加が認められた。モルモットは暑熱への耐性が弱く暑熱負荷の長期的な実験は困難であった。肝臓細胞内小器官の脂質過酸化は若齢では影響を受けていなかったが､高齢・老齢ラットのミトコンドリア､ミクロゾームでは脂質過酸化が著しく誘導されていた。ラットでは肝臓の細胞質グルタチオンペルオキシダーゼは高体温症で強く誘導されたが､モルモットでは誘導がみられなかった。肝臓カタラーゼ活性は若齢のラットでは暑熱ストレスによる影響を受けていなかったが､高齢・老齢ラットは肝臓､腎臓のいずれの臓器においても減少していた。高齢・老齢ラットにおける肝細胞の小胞体は暑熱ストレスにより変形していたため､ミクロゾームの電子伝達系酵素のアミノピリン脱メチル化酵素やTMPDペルオキシダーゼ活性について検討した。その結果､加齢につれていずれの酵素も活性の低下がみられ､週齢の高いラットでは暑熱暴露によりさらに活性が低下した。暑熱ストレスにより合成する蛋白質の立体構造形成が不安定化することを防ぐ分子シャペロンとしての機能を示す熱ショックタンパク誘導にはモルモットとラットで種差があり､モルモットでは核とミトコンドリアで90-kDaの熱ショックタンパクの誘導が認められ､ラットの単離細胞においては70-kDaの熱ショックタンパクの合成促進が観察された。両種において暑熱ストレスによる細胞機能の変調に対して､分子シャペロン機能を示す防御系が活性化したと考えられる。実験動物に暑熱ストレスを加え､臓器・組織を光学顕微鏡と電子顕微鏡を用いて観察した結果､肝臓､腎臓､心臓､呼吸器系､内分泌系､免疫系などにおいて､暑熱ストレスにより組織的変化が認められた。特徴的な組織的変化は肝臓の静脈周辺細胞の空胞変性､脂質過酸化物に起因するとみられる脂肪顆粒の貯留､欝血などであった。さらに動物の加齢により暑熱ストレスの影響が増強し､適応性が低下していると考えられる老齢期ラットでは顕著に暑熱ストレスの影響があらわれた。35℃の暑熱環境下では､暴露期間が長くなるほど病理組織学的な諸変化が増強していた。臓器・組織における最も顕著な変化は静脈系の拡張であった。心筋の空胞変性とともに､肝臓､腎臓､心臓､肺および骨髄などに欝血の傾向が認められた。この研究により､暑熱ストレスが組織学的変化を伴う生体組織の障害を引き起こすことが判明した。暑熱ストレスの増大は生体諸機能の低下している高齢者や高齢の動物に対し深刻な影響を及ぼすと予想される。
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en-aut-name=SatoKatsunori
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en-aut-name=AndoMitsuru
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affil-num=1
en-affil=
kn-affil=（財）日本農村医学研究所

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=富山国際大学

affil-num=4
en-affil=
kn-affil=松本歯科大学
END

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cd-journal=joma
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cd-vols=
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dt-revised=
dt-accepted=
dt-pub-year=1931
dt-pub=19310531
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kn-subject=
en-title=
kn-title=雜報
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kn-subtitle=
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kn-abstract=
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kn-copyright=

en-aut-name=
en-aut-sei=
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kn-aut-name=岡山医学会
kn-aut-sei=岡山医学会
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affil-num=1
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END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=5
article-no=
start-page=1089
end-page=1096
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1931
dt-pub=19310531
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en-article=
kn-article=
en-subject=
kn-subject=
en-title=Zusammenhang zwischen der Oxydasereaktion und dem Geschlechtszyklus des Geschlechtsorgans bei weiblichen M?usen
kn-title=「マウス」雌性生殖器ノ「オキシダーゼ」反應ト性週期トノ關係ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=?ber den Zusammenhang zwischen der Oxydasereaktion und dem Geschlechtszyklus des Geschlechtsorgans bei weiblichen M?usen ist bisher sehr selten berichtet worden. Daher besch?ftigte ich mich mit einer diesbez?glichen Untersuchung und erzielte die im folgenden zusammengefassten Resuitate: 1. Die Oxydasereaktion der Scheidenschleimhaut ist sehr schwach und zeigt keine deutliche zyklische Ab- und Zunahme. 2. Die Oxydasereaktion der Uterusschleimhaut ist je nach dem Stadium des Zyklus verschieden; sie ist beim Oestrus am st?rksten positiv und wird allm?hlich immer schw?cher, um dann beim Dioestrus am schw?chsten positiv zu werden. 3. Die Oxydasereaktion der Follikel der Ovarien wird mit der Entwicklung derselben immer st?rker. 4. Weder die Oxydasereaktion der prim?ren Follikel noch die der mittelm?ssig entwickelten Follikel scheint durch den Zyklus irgendwie beeinflusst zu werden. 5. Neu entwickelte und reife Corpora lutea pflegen eine positive Oxydasereaktion zu zeigen, jedoch ist diese Reaktion bei regressiv ver?nderten Corpora lutea meist negativ. 6. Die Zellen der Tunica vaginalis interna und die interstitiellen Zellen zeigen stets eine positive Reaktion ?ber den mittelm?ssigen Grad hinaus.
en-copyright=
kn-copyright=

en-aut-name=IkeiRyuzo
en-aut-sei=Ikei
en-aut-mei=Ryuzo
kn-aut-name=池井柳藏
kn-aut-sei=池井
kn-aut-mei=柳藏
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學産婦人科教室
END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=3
article-no=
start-page=638
end-page=663
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1931
dt-pub=19310331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber die Peroxydaaereaktion von Eiterzellen
kn-title=膿球ノ「ペルオキシダーゼ」反應ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Auch bei der Peroxydasereaktion der gonorrhoischen Eiterzellen zeigen nur die myeloischen Zellen wie bei den Dopa- und Indophenolreaktionen die Granulaf?rbung des Protoplasmas. Der Kern ist immer hell. Erythrozyten, Lymphozyten, Epithelzellen, Gonokokken u. a. k?nnen sich nicht verf?rben. Diese Reaktion gibt sowohl bei den frischen als auch bei den mit Formalindampf fixierten Ausstrichpr?paraten die gleichen positiven Ergebnisse, jedoch sehen wir bei den letzteren ein sch?neres Bild als bei den ersteren, ebenso wie es bei der Dopa- und Indophenolreaktion beobachtet wird. Wenn man die gef?rbten Pr?parate in Zedern?l, Balsam, Glycerin, Wasser u. a. einschliesst, so werden sie im Laufe der Zeit nach und nach undeutlicher; wenn sie aber trocken (ohne Einschliessungsmittel) gehalten werden, so weisen sie noch nach mehr als 3 Monaten fast keine Ver?nderung auf. Diese Reaktion ist in Bezug auf ihr Verhalten verschiedenen physikalisch-chemischen Einfl?ssen gegen?ber der Dopareaktion ganz ?hnlich: Die 15 Minuten lange Vorbehandlung mit ?thylalkohol, ?ther, Xylol, trockener Hitze (90°C) etc. beeintr?chtigt die Reaktion nicht, w?hrend Methylalkohol sie deutlich sch?digt und Salzs?ure (0.3%), Natronlauge (5%), warmes Wasser (70°C) u. a. sie vollat?ndig aufheben. Lassen sich jedoch die obigen Manipulationen als Nachbehandlung der Peroxydasereaktion vornehmen, so st?ren sie die Granul?farbung kaum.
Beim Einlegen in eine Formalinl?sung und in der freien Luft verlieren die Ausstrichpr?parate die F?rbungsf?higkeit mehr oder minder rasch, d. h. im ersteren Falle etwa nach 2 Wochen, im letzteren nach 2 Monaten, dagegen zeigen die in Formalindampf aufbewahrten Pr?parate eine positive Reaktion noch nach 4 Monaten. Im Gegensatz zur Indophenolreaktion kommt bei der Peroxydasereaktion eine Reaktivierung des einmal durch S?ure gesch?digten Pr?parates mittels einiger Metallverbindungen keineswegs zustande, ebensowenig wie bei der Dopareaktion. (Vergl. diese Zeitschr. Jg. 42, Nr. 7, 1930).
Bei der einfachen Verwendung von H(2)0(2)+ Benzidinl?sung verf?rben sich die K?rn-chen des Protoplasmas braun, und nach der Sato- u. Sekiyaschen Methode (Kupfermethode) erscheinen sie gr?nlich-blau odor tief blau. Diese Blauf?rbung wird ausser durch Kupfersulfat auch durch manche Metallsalzl?sungen hervorgerufen. Es scheint mir, dass eine gewisse Beziehung zwischen der Blauf?rbung und der Wasserstoffionenkonzentration der Metallsalzl?sungen vorliegt. Sowohl die alkalische als such die neutrale L?sung gibt den K?rnchen immer eine braune Farbe. Dagegen f?rben sich die Granulae durch saure L?sungen entsprechend ihrem S?urewerte in verschiedenen Graden blau. Bei den zu stark konzentrierten S?uren verf?rben sich die Zellen gar nicht mehr. Es besteht jedoch kein direkter Zusammenhang zwischen der Blauf?rbung und der echten Peroxydasereaktion. Die Blauf?rbung wird durch einen Oxydationsprozess von Benzidin unter S?urezusatz hervorgerufen, w?hrend die Leukozytengranulae dabei eine katalytische Wirkung aus?ben. Auf Grund der obigen Tatsachen kann kurz zusammengefasst gesagt werden, dass die Peroxydasereaktion in verschiedenen Punkten eine sehr grosse ?hnlichkeit mit der Dopareaktion der Eiterzellen besitzt.
en-copyright=
kn-copyright=

en-aut-name=UchidaShigeo
en-aut-sei=Uchida
en-aut-mei=Shigeo
kn-aut-name=内田茂雄
kn-aut-sei=内田
kn-aut-mei=茂雄
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學皮膚科泌尿器科教室
END

start-ver=1.4
cd-journal=joma
no-vol=43
cd-vols=
no-issue=2
article-no=
start-page=532
end-page=539
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1931
dt-pub=19310228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Arbeiten aus der Medizinischen Universit?t Okayama. 2. Bd., 2. H. 内容抄録
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山医学会
kn-aut-sei=岡山医学会
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=44
cd-vols=
no-issue=1
article-no=
start-page=71
end-page=78
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1932
dt-pub=19320131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber die histologische Ver?nderung der Schilddr?se, besonders ?ber die ihres Golgischen Apparatus nach Exstirpation der Milz
kn-title=脾剔出後ニ於ケル甲状腺ノ組織的變化殊ニ其Golgi氏裝置ノ變化ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Die Verfasser exstirpierten bei H?hnern die Milzen und t?teten die Tiere nach verschiedenen Lebenszeiten, um ihre Schilddr?sen mit Hilfe der Eosin-H?matoxylin-F?rbung und der Cajalschen Uransilbermethode zu untersuchen. Folgendes ist das Ergebnis: 5-15 Tage nach Milzexstirpation zeigt die Schilddr?se histologisch ein Zeichen der funktionellen Steigerung, indem die Follikelepithelzellen sich vermehren und h?her werden, wobei ihr Golgischer Apparat sich stark entwickelnd nach unten h?ufig bis zur Zellenbasis sich verbreitet, was am 10-15. Tage nach Operation am deutlichsten zu sehen ist. Vom 30. Tage nach Operation an f?llt aber die Schilddr?se allm?hlig einer regressiven Ver?nderung anheim. Diese Ver?nderung tritt am 45-60. Tage nach Operation sehr deutlich in die Erscheinung, indem die Follikelepithelzellen stark ihre H?he vermindern und ihr Golgischer Apparat in den Hintergrund tritt. Der letztere stellt sich meistens nur als wenige kurze St?bchen oder K?rnchen dar, oder verschwindet sogar ganz und gar. Die anf?ngliche Funktionssteigerung ist darauf zur?ckzuf?hren, dass mit Entfernung der Milz ihre hemmendende Wirkung auf die Schilddr?se beseitigt worden ist, w?hrend die sp?tere R?ckbildung wahrscheinlich darauf die urs?chliche Beziehung hat, dass durch Entfernung der Milz die antagonistische Wirkung der Schilddr?se auf jenes Organ allm?hlich unn?tig wird.
en-copyright=
kn-copyright=

en-aut-name=SumoriS.
en-aut-sei=Sumori
en-aut-mei=S.
kn-aut-name=陶守三思郎
kn-aut-sei=陶守
kn-aut-mei=三思郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學解剖學教室
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=9
article-no=
start-page=2168
end-page=2187
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1934
dt-pub=19340930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber die Verteilung der Oxydase tragenden Leukocyten in der Blutbahn
kn-title=「オキシダーゼ」負荷白血球ノ流血内分布ニ就テ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Verf hat von dem in verschiedene Organe ein-bezw. ausgehenden Arterien-bezw. Venenblut von normalen Kaninchen, solchen, bei denen das Retikuloendothelial-System mit Kollargol blockiert oder mit Silber-Elektrargol gereizt worden war, Strichpr?parate hergestellt und diese in 2 Gruppen eingeteilt. Die 1. Gruppe wurde nach Giemsa gef?rbt, die 2. Mittels der Oxydase-F?rbung. Von jeder Gruppe wurden die polynukle?ren Leukozyten in % der Lymphozyten gez?hlt und der Ausfall der Oxydase-Reaktion festgestellt. Die Ergebnisse dieser Untersuchungen waren die folgenden: 1.) Je nach dem System der Blutbahn ist der Prozentanteil der polynukle?ren Leukozyten mit Oxdase-K?rnern ein verschiedener. 2.) In allen Organen ausser der Milz enth?lt des Arterienblut mehr polynukle?ren Leukoxyten mit Ozydase-K?rnern als das Venenblut. Dieses Verh?ltnis ist in der Milz gerade umgekehrt. 3.) Die Ersache f?r diese Erscheinung ist in der zerst?renden Funktion der roten Blutk?rperchen in der Milz zu suchen. 4.) Ca. 5 Wochen nach der Exstirpation der Milz vermehren sich in den Leberzellen die Oxydasek?rner.
en-copyright=
kn-copyright=

en-aut-name=TerasakoShinji
en-aut-sei=Terasako
en-aut-mei=Shinji
kn-aut-name=寺迫新次
kn-aut-sei=寺迫
kn-aut-mei=新次
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學泉外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=7
article-no=
start-page=1627
end-page=1655
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1934
dt-pub=19340731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber die klinische Bedeutung der Milz auf Fettstoffwechsel der Leber. (I. Mitteilung.)
kn-title=肝臓脂肪新陳代謝機能ニ對スル脾臓ノ意義ニ就テ（第1報）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Der Verfasser studierte experimentelle ?ber die klinische Bedeutung der Milzgegen die Leber in bezug auf Fettstoffwechsel. Als Versuchtier benutzte das Hund und forschte haupts?chlich histologische Ver?nderung mitsamt biochemische Untersuchung der Leber. Die Ordnung der Untersuchung lautet; 1) Bez?glich der quantitativen Ver?ndernng von Fettablagerung der Leber und Fettgehalt im Blute forschte der Verfasser beim normalen Hunde genau chemisch und noch dazu histologisch. 2) Bei einer Gruppe von H?ndchen, die splenektomiert wurden, untersuchte der Verfasser haupts?chlich die Leberver?anderund und der Fettgehalt im Blute. 3) Diese Forschung setzte der Verfasser weiter nach Brockierung von R.E.S. mit 1% Collargollosung beim normale und splenektomierten H?ndchen fort. 4) Dann forschte der Verfasser obengenaunte Ver?nderung der Leber und des Blutes nach Injektion von 1% Collargoll?sung im Reizdose gegen R.E.S, 5) Nach Sch?digung von Funktion der Leberzellen mit CCl4 beim normalen und splenektomierten H?ndchen beobachtete der Verfasser 5 W, lang die Ver?nderung von Leber und Fettgehalt im Blute. 6) Zuletzt injcierte deu Reizdosis von CCl4 zu solchen H?ndchen und forschte genau oben genaunte Einzellheiten. Schl?sssatze; 1) Jede Sternzellen und Leberzellen haben besondere klinische Bedeutung auf Fettstoffwechsel der Leber und zwar stehen Jeder f?r sich in unterennbarer Beziehung. 2) Es schcint die Abnahme von Fettstoffwechsel der Leber durch Splenektomie hervortreten und infolgedessen wird die Ver?uderung von Fettstoffwechsel der Leber herbeif?hren. 3) Die Hyperlip?mie nach Milzexstirpation soll seine Ursache nicht nur auf die Funktionsst?rung von R.E.S. sondern auch auf solche von Leberzellen zur?ckzuf?hren.
en-copyright=
kn-copyright=

en-aut-name=OnoTetsuji
en-aut-sei=Ono
en-aut-mei=Tetsuji
kn-aut-name=小野哲二
kn-aut-sei=小野
kn-aut-mei=哲二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學石山外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=49
cd-vols=
no-issue=12
article-no=
start-page=2357
end-page=2367
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1937
dt-pub=19371231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber den Einfluss der Gallens?ure auf den Harns?urestoffwechsel. II. Einfluss der Gallens?ure auf die Xanthinoxydase.
kn-title=尿酸新陳代謝ニ及ボス膽汁酸ノ影響（第2報）「キサンチンオキシダーゼ」ニ及ボス膽汁酸ノ影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Um einen genaueren Einblick in den Einfluss der Gallens?ure auf den Harns?urestoffwechsel zu gewinnen, wurde der Einfluss der Chols?ure auf die Xanthinoxydase in der Hundemilz bei Zusatz von Xanthin untersucht. Es wurde dabei gefunden, dass die Xanthinoxydase ein pH-Optimum von 8,2 hat und dass die Cholsaure bei diesem PH-Wert am st?rksten die Wirkung der Xanthinoxydase in Milz f?rdert. Dabei wurde die Xanthinoxydase nur in der Milz von Kaninchen nachgewiesen, aber nicht in der Niere und im Muskel.
en-copyright=
kn-copyright=

en-aut-name=TakeutiNobuo
en-aut-sei=Takeuti
en-aut-mei=Nobuo
kn-aut-name=竹内信夫
kn-aut-sei=竹内
kn-aut-mei=信夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學生化學教室
END

start-ver=1.4
cd-journal=joma
no-vol=49
cd-vols=
no-issue=5
article-no=
start-page=1106
end-page=1110
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1937
dt-pub=19370531
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=雜報
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山医学会
kn-aut-sei=岡山医学会
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=7
article-no=
start-page=1583
end-page=1604
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1939
dt-pub=19390731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=?ber 2 F?lle von aleukaemischer Lymphadenose
kn-title=Aleukaemische Lymphadenoseノ2剖檢例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Erster Fall: Ein 57-j?hriger heruntergekommener Kaufmann wurde am 27.11. 1936. in unsere Klinik aufgenommen. Status praesens: Statur mittelgross, Koerperbau m?ssig, Ern?hrung sehr schlecht, Haut und Schleimhaut deutlich an?misch, Lippe und Zunge mehr trocken, rechtseicht aufgetrieben, Ascitesfl?ssigkeit nicht vorhanden, Leber in der Mamillalinie 3 querfingerbreit unterhalb des Rippenbogens derb f?hlbar. Aufallendste Befunde waren Lymphdr?senanschwellungen. Submaxillare, cervicale, axillare und inguinale Lymphdr?sen waren von Taubenei- bis uber Huhnereigr?sse angeschwollen, elastisch derb, gut beweglich, nicht so druckempfindlich, sowohl mit der Haut, als auch miteinander nicht verwachsen. Wassermann negativ. Urin normal. Leukozyten 9.200, H?moglobin 22%, Erythrozyten 3, 420, 000. Das Blutbild ergibt basophile Leukozyten 2%, Eosinophile L. 0%, Stabkernige L. 1%, Segmentkernige L 43%, Lymphozyten 48%, gr?sse mononukle?re Zellen und ?bergangsform 5%. Beobachtenswert ist die sehr geringe Vermehrung in der Gesamtzahl der Leukozyten. Eine Lymphdr?se wurde aus der Achselhohle exstirpiert und histologisch untersucht und nur eine Lymphozyteninfiltration konstatiert. Die Lymphknoten waren durch Rontgentherapie sehr verkleinert worden. Der Patient verliess am 12.12. das Krankenhaus, um am 11. 1. 1937. wieder zur?ckkehren. Seit der Entlassung hatte er wieder Lymphdr?senanschwellung und hochgradige Schw?che. Exitus letalis am 2. 2. 1937. Bei der Sektion einwandfrei lymphatische, leukaemische Infiltration sowohl in den blutbildenden Organen, wie auch in fast allen anderen Geweben nachgewiesen. Die lymphatische Zellen hatten zweifellos auch das Knochenmark ergriffen, die erythroblastischen Zentren in Mitleidenschaft gezogen und hatten zu einer Blutarmut gef?hrt. 2ter Fall: Ein 23-j?hriger Bauer kam am 20. 9. 1937. in einen das Krankenhaus. Vor 5 Monaten bemerkt er am r-Seitenhals einen erbsengrossen Tumor, der sich allm?hlich vergr?ssert und vermehrt, aber beschwerdelos verlauft. Seit Monaten mit der Zeit cervicale (1-), submaxillare und inguinale Lymphdrusen. Diese waren von Taubenei-bis ?ber H?hnereigrosse angeschwollen nebeneinander, elastisch derb, nicht so druckempfindlich, mit der Unterlage fixiert, aber mit der Haut nicht verwachsen. Keine Atmungs-und Schluckbeschwerde. Appetit normal. Fieber 37-37.5°C. Urin normal. WaR. negativ. Blutsenkungsgeschwindigkeit 5.5 (1st), 15 (2st). Leukozyten 4.4000, Hamoglobin 90%, Erythrozyten 518, 000. Das Blutbild ergibt Lymphozyten 42%, neutrophile L. 43%, stabkernige L. 5%, Monozyten und ?bergangsform 9.5%, keine jugendlichforme Leukozyten. Eine Lymphdr?se wurde aus dem Seitenhals exstirpiert und histologisch untersucht und nur eine Lymphozyteninfiltration konstatiert. Die Untersuchung erwiess aleukaemische Lymphadenose. Nach 7 Monaten exitus letalis. Im Vordergrund der heutigen Therapie steht die Strahlentherapie, vor allem Rontgenbehandlung. Wichtig und erfolgreich ist die Arsen-Behandlung. Sie wird angewandt, wenn die Arsentherapie erfolglos und der Allgemeinzustand und das ganze Krankheitsbild einer Behandlung bed?rftig ist. Die Rontgenbestrahlung richtet sich hier vor allem gegen die peripheren Lymphdr?senpakete, aber auch gegen die Milz, selbst wenn sie nicht wesentlich vergr?ssert ist, weil oftmals erst nach der Milzbestrahlung die Leukozytenzahl zur Norm absinkt, obwohl die Lymphdr?sen vorher schon zuruckgingen. Mit 30% H.E.D. auf jedes Feld, wobei man 1 Feld pro Tag vornimmt und die Leukozytenzahl t?glich kontrolliert. Die Intensivbestrahlung, die einen plotlichen tiefen Absturz bringt, ist vollig unzweckm?ssig, wie auch jede nicht genau kontrollierte Strahlentherapie. Sie kann direkt sch?dlich seiu dadurch, dass die Leukozytenzahl schnell unter die Norm sinkt und diesem starkem Abfall rasch wieder eine Verschlimmerung und ein h?her Anstieg mit Komplikation des roten Blutbildes usw. folgt (Reizwirkung). Die Rontgenbehandlung wird wiederholt, wenn das Krankheitsbild sich wieder verschlechert. Sie hat aber dann m?glichst bald einzusetzen und nicht erst bei weitgehender Verschlimmerung. Der Kranke muss also in dauernder Beobachtung bleiben und alle 3-4 Wochen soll ein morphologischer Blutstatus aufgenommen werden. In der Zeit zwischen den eiuzelnen R?ntgenbestrahlungen nimmt man zweckm?ssigerweise Arsentherapie vor. Rezidive treten immer auf. Die Leukaemie ist durch kein Mittel zu heilen. Sie wird vielmehr ?ber kurz oder lang gegen jede Behandlung auch die Strahlenbehandlung refrakt?r und f?hrt schliesslich unter dem Bild einer akuten Verschlechterung oder durch Komplikationen zum Tode. Die R?ntgentherapie muss abgebrochen werden, wenn die Zahl der weissen Blutzellen sehr schnell und tief absinkt, wenn zahlreiche unreife Zellen auftreten, wenn das rote Blutbild aber das Allgemeinbefinden sich unter der Bestrahlung akut verschlechtert, und Gewichtssturz, Durchf?lle und h?heres Fieber eintreten. Ber vorsichtiger Dosierung und dauernder strenger Kontrolle jeder einzelnen Bestrahlung treten aber derartige Verschlimmerungen erst nach evtl.langj?hriger Bestrahlung auf.
en-copyright=
kn-copyright=

en-aut-name=KuwabaraSei
en-aut-sei=Kuwabara
en-aut-mei=Sei
kn-aut-name=桑原正
kn-aut-sei=桑原
kn-aut-mei=正
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山醫科大學津田外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=52
cd-vols=
no-issue=4
article-no=
start-page=1002
end-page=1012
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1940
dt-pub=19400430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=雑報
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山医学会
kn-aut-sei=岡山医学会
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=100
cd-vols=
no-issue=
article-no=
start-page=3
end-page=7
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2011
dt-pub=20110201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Purification and Characterization of l-Methionine Decarboxylase from Streptomyces sp. 590
kn-title=放線菌Streptomyces sp.590由来l-メチオニン脱炭酸酵素の精製および性質検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=L-Methionine decarboxylase [EC 4.1.1.57] catalyzes the decarboxylation of L-methionine and is a pyridoxal 5’-phosohate(PLP)-dependent enzyme. L-Methionine decarboxylase has been purified 630-fold by DEAE-Toyopearl 650M, Phenyl-Toyopearl 650M and Sephacryl S-300 column chromatographies from Streptomyces sp.590. The enzyme has a dimeric structure with identical subunits of Mr 60,000. This enzyme shows optimum activity at pH7.0 and 45°C, and is stable between pH5.7 and pH9.0. L-Methionine decarboxylase has antitumor activity against RERF-LC-AI and HeLa cells. Ten N-terminal amino acid sequence of L-methionine decarboxylase was determined, and the sequence showed no homology with other reported proteins.
en-copyright=
kn-copyright=

en-aut-name=MaemuraTomomi
en-aut-sei=Maemura
en-aut-mei=Tomomi
kn-aut-name=前村知美
kn-aut-sei=前村
kn-aut-mei=知美
aut-affil-num=1
ORCID=

en-aut-name=UchitomiKumiko
en-aut-sei=Uchitomi
en-aut-mei=Kumiko
kn-aut-name=内富久美子
kn-aut-sei=内富
kn-aut-mei=久美子
aut-affil-num=2
ORCID=

en-aut-name=KusakaChika
en-aut-sei=Kusaka
en-aut-mei=Chika
kn-aut-name=日下知香
kn-aut-sei=日下
kn-aut-mei=知香
aut-affil-num=3
ORCID=

en-aut-name=InagakiJunko
en-aut-sei=Inagaki
en-aut-mei=Junko
kn-aut-name=稲垣純子
kn-aut-sei=稲垣
kn-aut-mei=純子
aut-affil-num=4
ORCID=

en-aut-name=TamuraTakashi
en-aut-sei=Tamura
en-aut-mei=Takashi
kn-aut-name=田村隆
kn-aut-sei=田村
kn-aut-mei=隆
aut-affil-num=5
ORCID=

en-aut-name=SodaKenji
en-aut-sei=Soda
en-aut-mei=Kenji
kn-aut-name=左右田健次
kn-aut-sei=左右田
kn-aut-mei=健次
aut-affil-num=6
ORCID=

en-aut-name=InagakiKenji
en-aut-sei=Inagaki
en-aut-mei=Kenji
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=農芸化学コース

affil-num=2
en-affil=
kn-affil=農芸化学コース

affil-num=3
en-affil=
kn-affil=農芸化学コース

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=5
en-affil=
kn-affil=農芸化学コース

affil-num=6
en-affil=
kn-affil=京都大学

affil-num=7
en-affil=
kn-affil=農芸化学コース
en-keyword=L-methionine decarboxylase
kn-keyword=L-methionine decarboxylase
en-keyword=pyridoxal 5’-phosohate
kn-keyword=pyridoxal 5’-phosohate
en-keyword=Streptomyces
kn-keyword=Streptomyces
en-keyword=decarboxylation of L-methionine
kn-keyword=decarboxylation of L-methionine
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=11
article-no=
start-page=2185
end-page=2189
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Quantity of Catalase and Peroxydase in Acatalasemia Cases and Quantity of Catalase in Wild duck, Goose and Pigeon Part III. Quantity of Peroxydase in Acatalasemia Cases
kn-title=無カタラーゼ血液症に於るカタラーゼ量，ペルオキシダーゼ量並に家鴨，鵞鳥，鳩に於るカタラーゼ量に就て 第三編 無カタラーゼ血液症血液ペルオキシダーゼに就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I performed the quantitative estimation of peroxydase in blood of acatalasemia cases, using Bach-Zubkowa's method, and peroxydase reaction of blood were tested according to Mc Junkin's method. Obtained results were as follows: 1) Quantity of peroxydase of blood in acatalasemia were almost equal to normal persons. 2) Peroxydase reaction of blood in acatalasemia cases were almost the same in comparison with that of normal person's blood.
en-copyright=
kn-copyright=

en-aut-name=MiharaShin
en-aut-sei=Mihara
en-aut-mei=Shin
kn-aut-name=三原伸
kn-aut-sei=三原
kn-aut-mei=伸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=11
article-no=
start-page=2175
end-page=2183
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Quantity of Catalase and Peroxydase in Acatalasemia Cases and Quantity of Catalase in Wild duck, Goose and Pigeon Part II. Quantity of Catalase in Organ's Tissues of Wild duck, Goose and Pigeon
kn-title=無カタラーゼ血液症に於るカタラーゼ量，ペルオキシダーゼ量並に家鴨，鵞鳥，鳩に於るカタラーゼ量に就て 第二編 家鴨，鵞鳥，鳩の各臓器組織カタラーゼ量に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I examined the quantity of catalase in organ's tissues of wild duck, goose and pigeon, whose blood in reacting to hydrogen peroxide showed a close resemblance to the blood acatalasemia cases. When we poured hydrogen peroxide on to the blood of these fowl, the blood discolored immediately into a blackish color, and at that time no generation of bubbles could be seen. I used Warburg's manometric method and following results were obtained: I found that Qcat. of blood and bone marrow of these fowl showed an extremely low number, while the Qcat. of liver, kidney and small intestine of these fowl were almost equal index number to those of other animals.
en-copyright=
kn-copyright=

en-aut-name=MiharaShin
en-aut-sei=Mihara
en-aut-mei=Shin
kn-aut-name=三原伸
kn-aut-sei=三原
kn-aut-mei=伸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=11
article-no=
start-page=2167
end-page=2173
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1956
dt-pub=19561130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Quantity of Catalase and Peroxydase in Acatalasemia Cases and Quantity of Catalase in Wild duck, Goose and Pigeon Part I. Quantity of Catalase in blood and Tissues of Acatalasemia Cases
kn-title=無カタラーゼ血液症に於るカタラーゼ量，ペルオキシダーゼ量並に家鴨，鵞鳥，鳩に於るカタラーゼ量に就て 第一編 無カタラーゼ血液症血液並に組織カタラーゼ定量
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=I performed the quantitative estimation of catalase in blood and tissues of acatalasemiacases, using Warburg's manometric method, that was applied according to Fujita-Kodama's technic, and following results were obtained: 1) When I performed the quantitative estimation of catalase in 1/1000 diluted blood as ordinary method, Qcat in blood of Acatalasemia were 0, but when I examined the quantity of catalase in the not diluted blood of acatalasemia, these Qcat were about 510. When I compared Qcat. of acatalasemia's blood with Qcat of a normal person's blood, the ratio between them was about 1/5001/1000 and then it was an extremely small amout. 2) The tissues of nose and mouth in acatalasemia cases contained no catalase
en-copyright=
kn-copyright=

en-aut-name=MiharaShin
en-aut-sei=Mihara
en-aut-mei=Shin
kn-aut-name=三原伸
kn-aut-sei=三原
kn-aut-mei=伸
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科教室
END

start-ver=1.4
cd-journal=joma
no-vol=69
cd-vols=
no-issue=4
article-no=
start-page=1103
end-page=1109
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1957
dt-pub=19570430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Action of Some Bacteria on Erythrocytes Part 1: Catalase and Peroxidase Activities, and Respiration of Pneumococci, Streptococci and Erythrocytes
kn-title=二，三細菌の赤血球に及ぼす影響について 第1編 各種動物血球，肺炎菌及び連鎖球菌のカタラーゼ，ペルオキシダーゼ及び呼吸量
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The studies on the hemolytic action of pneumococci and streptococci have been conducted principally with the use of catalase carrier blood. Prof. Takahara has recently encountered the patients whose blood carried hardly any catalase. For the fundamental investigation for acatalasemia, some experiments have been attempted about actual hemolytic picture of some bacteria acting upon the catalase and non-catalase carrier blood. In the present report, blood of man, goat, guinea pig, and rabbit were used as catalase carrier, and that of domestic duck as non-catalase carrier. As for the bacteria, Pneumococcus type I, II and III, Streptococcus hemolyticus (Cook strain), and Streptococcus viridans have been employed for the experiments. And by measuring the catalase and peroxidase activity and respiration of each experimental materials, the following results have been obtained. 1. Erythrocytes and blood of man, goat, rabbit and guinea pig contains catalase, but there is practically no substantial difference in their contents; whereas that of domestic duck hardly possesses any catalase. 2. Peroxidase activities both in the catalase carrier and the non-catalase carrier erythrocytes and blood are approximately the same. 3. O(2) uptake during respiration of domestic duck erythrocytes are far more than those of the catalase carriers, and this can be assumed to be dependent upon the presence or absence of nuclei as well as upon the amount of stroma. 4. Catalase activities in Pneumococcus type I, II and III are negative, and are slightly positive in St. hemolyticus and St. viridans. 5. Peroxidase activities in these bacteria nearly coincide. 6. No marked differences can be found in O(2) uptake among the bacteria employed in the experiments.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoMansuke
en-aut-sei=Matsumoto
en-aut-mei=Mansuke
kn-aut-name=松本万輔
kn-aut-sei=松本
kn-aut-mei=万輔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=シロイヌナズナにおけるペルオキシダーゼを媒介したサリチル酸，酵母エリシター，キトサン誘導気孔閉口
kn-title=Involvement of peroxidases in salicylic acid-, yeast elicitor-, and chitosan-induced stomatal closure in Arabidopsis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Md. AtiqurRahman Khokon
en-aut-sei=Md. Atiqur
en-aut-mei=Rahman Khokon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=9-2
article-no=
start-page=6145
end-page=6165
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Changes of Eosinophil Leucocytes in Alveolar Pyorrhea
kn-title=歯槽膿漏症に於ける好酸球の消長に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hematological researches in peripheral blood, especially the changes of eosinophils were made from various points in order to solve the nature and etiology of alveolar pyorrhea. The results obtained are summarized as follows: 1) Little difference was recognized on red cell count, hemoglobin quantity and index in comparison with healthy control cases. No remarkable quantitative and qualitative changes of white cells except eosinophils were observed. In addition, any apparent difference between peripheral blood taken from the ear lobe and local gingiva could not be found in these above-mentioned points,  2) Increase of eosinophils was recognized in about 45 per cent of 78 cases, and, moreover, its remarkable relationship to clinical type, especially that of inflammatory findings characterstic of the disease, was suggested. Many cases showing morphological changes, especially degenerative changes of the cells, were observed, and, furthermore, relationlhip between changes of the cells and those of the disease conld be suggested as the experimental results 3) Peroxidizing reaction of the peripheral blood cells by the vitamin C method was investigated in 20 cases showing an increase of eosinophils. Consequently, quite difference could be observed in staining ability of granules between clinical cases and control cases, and thus it could be noticed that granules within the cells in case of alveolar pyorrhea were quantitatively different from those in normal ones. 4) As a result of vital observations on movement of eosinophils by the peripheral blood culture method in 10 cases of the disease, it was recognized that the migration velocity of the cells showed a rapid decrease as time went by and was markedly inferior to that of normal cases and that in the mobility form the cells suggestive findings of declining mobility increased much more than those of normal cases, especially showing a increasing tendency with the progress of culture. All of these various findings of the cells can not necessarily be considered to be the phenomena characteristic of this disease, but pathologic findings and characterics of the cells of this disease may suggest both correlation of the cells to chronic inflammatory changes in case of alveolar pyorrhea and possibility of allergic process as an etiologic factor of the disease.
en-copyright=
kn-copyright=

en-aut-name=SakuraiYasuo
en-aut-sei=Sakurai
en-aut-mei=Yasuo
kn-aut-name=桜井靖郎
kn-aut-sei=桜井
kn-aut-mei=靖郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部歯科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=9-1
article-no=
start-page=5435
end-page=5439
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Influence of the Function of Adrenal Cortex upon the Duration of Intravenous Anesthesia Part 2. The relationship between Thorn-test value and anesthetic duration in rabbits with normal adrenal cortex
kn-title=副腎皮質機能の静脈麻酔時間に及ぼす影響に関する研究 第2編 副腎皮質正常家兎におけるThorn-test値と麻酔時間との関係について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=1) The value of eosinophile leukocytes of normal rabbits estimated by SAKURADA's modification with wet eosinperoxydase was 30-110. It was constant in the same rabbit. 2) For the Thorn-test in rabbits, 10 mg of ACTH was injected intravenously and after 5 hours the decreasing ratio of eosinophile leukocytes was estimated. The greater part was 50-65%. Accordingly, those more than 50% are regarded as the normal function of adrenal cortex and those less than 50% are counted as hypofunction. 3) Between the Thosn-test value and the duration of anesthesia, there is a logarithmic curve relation: the less the value is, the longer the duration of anesthesia stands. 4) The weight of adrenalin is 700±25mg i. e. it applies to nearly 0.03-0.04% of body weight. There is no difference between left and right side.
en-copyright=
kn-copyright=

en-aut-name=KawasakiToshio
en-aut-sei=Kawasaki
en-aut-mei=Toshio
kn-aut-name=川崎俊夫
kn-aut-sei=川崎
kn-aut-mei=俊夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=5-6
article-no=
start-page=659
end-page=672
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Expression and purification of the HIV-1 env gene products in Escherichia coli
kn-title=HIV-1エンベロープ蛋白質の大腸菌での発現と精製
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To purify the HIV-1 envelope protein with antigenic reactivity, the Pvu II-Bgl II fragment of the HIV-1 env gene, from the Pvu II site to the second Bgl II site, encoding the carboxyl terminal 180 amino acids of the viral surface protein (SU, gp120) was molecularly cloned in Escherichia coli strain HB101 using protein A expression-shuttle vector pRIT5. The pRIT5 contains the protein A gene, encoding the secretion signal and IgG binding domain of protein A with the upstream promoter and the downstream multicloning sites, as well as the two replication sites for Escherichia coli and Staphylococcus aureus. A fused protein with the molecular weight of about 55 kilodaltons was produced, which showed the same reactivity as the native protein A against rabbit serum IgG on Western blotting analysis. Most of the fused protein in the periplasmic space was degraded, while the complete fused protein inside the cells was recovered as an insoluble protein. The fused protein was solubilized with sodium dodecylsulfate (SDS), partially purified by IgG sepharose affinity chromatography, and completely purified by SDS-polyacrylamide gel electrophoresis. The quantity of the expressed fused protein was estimated about 1% of the total proteins. The purified fused protein contained 516 amino acids with Mr54, 976, consisting of 305 amino acids of the IgG binding domain of protein A, 5 amino acids derived from polylinker, a carboxyl terminal 180 amino acids of the HIV-1 envelope surface protein gp120, and 26 amino acids derived from the pUC19 sequence.
en-copyright=
kn-copyright=

en-aut-name=ZhangBo
en-aut-sei=Zhang
en-aut-mei=Bo
kn-aut-name=張波
kn-aut-sei=張
kn-aut-mei=波
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌源研究施設生化学部門
en-keyword=HIV-1
kn-keyword=HIV-1
en-keyword=エンベロープ蛋白質
kn-keyword=エンベロープ蛋白質
en-keyword=発現ベクター
kn-keyword=発現ベクター
en-keyword=Protein A
kn-keyword=Protein A
en-keyword=IgG-Sepharoseカラム
kn-keyword=IgG-Sepharoseカラム
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=1-2
article-no=
start-page=155
end-page=166
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Detection of gene expression in cells trasfected with recombinant DNA by in situ hybridization
kn-title=遺伝子導入細胞における遺伝子発現のin situハイブリダイゼイションによる検出
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Expression of mRNA in monolayer cells transfected with recombinant DNA was demonstrated by in situ hybridization with biotin- or (32)P-labeled probes. The biotin-labeled probe and hybrid detection system used in this study could detect 1 pg of target DNA and a single copy gene in mammalian cells using filter hybridization techniques. Several conditions of in situ hybridization were optimized with neomycin resistant (neo(r)) cells, which constitutively expressed neo(r) mRNA derived from pSV2neo. The proteolytic digestion was found to be the most critical procedure. The in situ hybridization demonstrated that neo(r) mRNA was localized in the cytoplasm of the neo(r) cells. Cf2Th cells derived from a canine fetal thymus cell were transfected with the cloned provirus genome of a retrovirus produced in a human lymphoblastoid cell line, and transient expressions of viral RNA and antigens were monitored by in situ hybridization and immunoperoxidase staining, respectively. About 48 hours after transfection, several percent of the transfected cells were positive for expression of both viral RNA and antigens by these cytochemical methods. These observations indicate that in situ hybridization is a useful method for detecting the expression of the gene introduced into mammalian cells.
en-copyright=
kn-copyright=

en-aut-name=MurakamiMasashi
en-aut-sei=Murakami
en-aut-mei=Masashi
kn-aut-name=村上雅
kn-aut-sei=村上
kn-aut-mei=雅
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌源研究施設生化学部門
en-keyword=in situハイブリダイゼイション
kn-keyword=in situハイブリダイゼイション
en-keyword=ビオチン標識プローブDNAトランスフェクション
kn-keyword=ビオチン標識プローブDNAトランスフェクション
en-keyword=遺伝子発現
kn-keyword=遺伝子発現
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=1-2
article-no=
start-page=97
end-page=105
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1989
dt-pub=198902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunohistochemical studies on the binding of lectin (PNA) and human anti-liver cell membrane antibody to the hepatic carcinoma cell membrane of rats fed 3'-methyl-4-dimethylaminoazobenzene (DAB)
kn-title=ラットDAB肝癌の免疫組織学的研究―レクチンおよびヒト由来の肝細胞膜抗体の反応性について―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Membrane changes of DAB hepatic carcinoma cells were examined immunohistochemically, using the binding activity of Arachis hypogaea agglutinin (PNA) and anti-liver membrane antibody (anti-LM) from patients with HBsAg-negative chronic active hepatitis. The hepatic carcinoma in rats was produced through DAB feedings for 3-5 months. As controls, non-cancerous liver tissues from rats fed DAB, and normal rat liver were used. In isolated calls of the hepatic carcinoma and control tissues, FITC-PNA binded in 10 of 11 cases of DAB hepatic carcinoma and in none of control cases (11 rats fed DAB and 2 normal rats). In tissue sections, similar results were obtained. Lens culnaris agglutinin did not show any difference in binding among the 3 groups. Two anti-LMs did not bind to the membranes of isolated calls in 3 of 10 DAB hepatic carcinomas, although the anti-LMs were bound in all of controls. These facts indicate that the transformation, DAB hepatic carcinoma cells is accompanied by changes in the cell membrane, and that PNA may be useful in the analysis of membrane changes in carcinogenesis.
en-copyright=
kn-copyright=

en-aut-name=TomidaOsamu
en-aut-sei=Tomida
en-aut-mei=Osamu
kn-aut-name=冨田治
kn-aut-sei=冨田
kn-aut-mei=治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科学教室
en-keyword=DAB肝癌
kn-keyword=DAB肝癌
en-keyword=PNA
kn-keyword=PNA
en-keyword=肝細胞膜抗体免疫蛍光法
kn-keyword=肝細胞膜抗体免疫蛍光法
en-keyword=レクチン蛍光法
kn-keyword=レクチン蛍光法
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=11-12
article-no=
start-page=1333
end-page=1343
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199012
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A clinicopathological study on acute renal failure - Histochemical and immunoenzyme-histochemical analysis -
kn-title=急性腎不全発症に関する臨床・病理学的研究―組織化学的，免疫組織化学的検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study was performed to determine whether disseminated intravascular coagulation (DIC) contributes to the pathogenesis of acute renal failure. Based on clinical feature informations including laboratory tests, 73 cases were selected from among 3, 769 cases autopsied between 1969 and 1984 at Okayama University Medical School and Himeji Red Cross Hospital. The 73 cases were composed of 66 cases of clinically diagnosed acute renal failure and 7 cases without renal failure serving as controls. The renal tissue sections stained by histochemistry (PTAH) or immunoenzyme-histochemistry (Fibrinogen, FDP-D and-E) were examined in order to detect Fibrin-Related Materials (FRMs) in the glomerular capillaries and tubuli. Microscopic observation revealed that the staining intensity of FRMs by immunoenzyme-histochemistry was much greater than that by histochemistry, but no marked difference existed between Fibrinogen and FDP in that regard. FRMs were negative in all control cases. In contrast, FRMs were positive in 59 cases (89.4%) of acute renal failure, though FRMs were detected in the glomeruli only in 8 cases (12.1%), tubuli only in 20 (30.3%), and in both the glomeruli and tubuli in 31 cases (47%).
These results sugessted that DIC contributes pathophysiologically to the induction of acute renal failure.
en-copyright=
kn-copyright=

en-aut-name=WakabayashiTakanobu
en-aut-sei=Wakabayashi
en-aut-mei=Takanobu
kn-aut-name=若林隆信
kn-aut-sei=若林
kn-aut-mei=隆信
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=急性腎不全
kn-keyword=急性腎不全
en-keyword=汎発性血管内凝固症候群
kn-keyword=汎発性血管内凝固症候群
en-keyword=免疫組織化学
kn-keyword=免疫組織化学
END

start-ver=1.4
cd-journal=joma
no-vol=102
cd-vols=
no-issue=5-6
article-no=
start-page=651
end-page=662
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunohistochemical study of transthyretin in normal brain and brain tumors - Light and electron microscopic investigation with special reference to choroid plexus papilloma and ependymoma -
kn-title=正常脳および脳腫瘍におけるtransthyretin局在に関する免疫組織化学的検索―Choroid plexus papillomaおよびependymomaを中心とした光顕および電顕的検索―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An immunohistochemical study of transthyretin (TTR), synthesized in the choroid plexus epithelia, was performed in normal brain tissue and 92 brain tumors. Glial fibrillary acidic protein (GFAP) and cytokeratin (CKER) were also examined in 11 choroid plexus papillomas (CPPs) and 19 ependymomas. A positive TTR reaction was observed diffusely in the majority of normal choroid plexus epithelia. All of the 11 cases of CPP were positive for TTR, but the other tissues and tumors (including ependymomas) were negative for TTR. GFAP -positive cells were occasionally found in five of the CPPs. The majority of the GFAP -positive cells were also positive for CKER, but not for TTR. There was an inverse relationship between the intensity of immunostaining for GFAP and for TTR in CPPs. Among the 19 cases of ependymomas, 16 were positive for GFAP, 3 for CKER, but none for TTR. TTR can be a very useful and diagnostic marker of CPP. A consective semithin-thin section microscopic method demonstrated abundant secretory granules and well-developed Golgi apparatus in TTR-positive cells. By immunoelectron microscopy using a pre-embedding method, a positive reaction for TTR was observed in the secretory granules. This result suggested that CPP cells as well as choroid plexus cells synthesize TTR de novo.
en-copyright=
kn-copyright=

en-aut-name=KunishioKatsuzo
en-aut-sei=Kunishio
en-aut-mei=Katsuzo
kn-aut-name=国塩勝三
kn-aut-sei=国塩
kn-aut-mei=勝三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学脳神経外科学教室
en-keyword=transthyretin
kn-keyword=transthyretin
en-keyword=choroid plexus papilloma
kn-keyword=choroid plexus papilloma
en-keyword=免疫組織化学
kn-keyword=免疫組織化学
en-keyword=brain tumor
kn-keyword=brain tumor
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=アカタラセミアマウスにおけるアロキサン誘発糖尿病発症および膵ラ氏島細胞アポトーシスの亢進について
kn-title=Sensitization to alloxan-induced diabetes and pancreatic cell apoptosis in acatalasemic mice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KikumotoYoko
en-aut-sei=Kikumoto
en-aut-mei=Yoko
kn-aut-name=菊本陽子
kn-aut-sei=菊本
kn-aut-mei=陽子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=48
cd-vols=
no-issue=
article-no=
start-page=13
end-page=23
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1979
dt-pub=19790325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Determination of copper and zinc in synovial fluid by atomic absorption spectrophotometry
kn-title=原子吸光分光分析法による関節液中銅･亜鉛の同時測定について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Copper (Cu) and zinc (Zn) in synovial fluids of 52 patients with rheumatoid arthritis (RA) and of 53 patients with osteoarthritis (OA) were determined using a HITACHI MODEL 207 atomic absorption spectrophotometer. Standard solution of Cu and Zn were 50μg, 100μg, 200μg and 300μg per 100 ml 20 v/v % glycerine containing 0.01 N-HCl. To 0.5ml synovial fluid, 50 units of hyaluronidase was added and then the mixture were incubated for 20 minutes at 37℃. Synovial fluid treated with hyaluronidase and standard solution of Cu and Zn were diluted five fold with deionized distillation water, then aspirated directly into the burner. The relative absorbance was expressed as scale reading by a HITACHI MODEL QPD-54 recoder. The mean recovery rate of Cu and Zn in synovial fluids were 102.0% and 101.9%. By this method the concentrations of Cu and Zn in 52 RA (12 males, 40 females) were 97.6±29.0 (S.D.) μg/100 ml and 83.9±40.1 (S.D.) μg/100 ml ; 97.3±27.1 (S.D.)μg/100 ml, 78.7±29.9 (S.D.) μg /100 ml in 12males and 97.7±29.5 (S.D.) μg/100 ml, 85.5±42.6 (S.D.) μg /100 ml in 40 females respectively. The concentrations of Cu and Zn in 53 OA (14 males, 39 females) were 46.9±14.5 (S.D.) μg/100 ml and 40.8±14.3 (S.D.) μg/100 ml; 47.3±9.7 (S.D.) JLg/100 ml, 45.1±19.0 (S.D.) μg/ 100 ml in 14 males and 46.8±15.8 (S.D.) μg/100 ml, 39.3±11.8 (S.D.) μg/100 ml in 39 females respectively. No sex differences of Cu and Zn values were observed in both RA and OA. In patients with RA, concentrations of Cu and Zn in synovial fluids were signifcantly higher than in OA in both sexes. There were positive correlation between the concentrations of Cu and Zn in 105 patients (RA and OA, r=0.74, p<0.01) , in 52 RA (r=0.54, p<0.01), in 53 OA (r=0.81, p<0.01). In patients with RA, there were no correlation between stage and concentrations of Cu and Zn in synovial fluids.
en-copyright=
kn-copyright=

en-aut-name=FurunoKatsushi
en-aut-sei=Furuno
en-aut-mei=Katsushi
kn-aut-name=古野勝志
kn-aut-sei=古野
kn-aut-mei=勝志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学温泉研究所温泉内科学部門
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=
article-no=
start-page=24
end-page=27
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1988
dt-pub=198804
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=鳥類の卵殻腺におけるカルシウム分泌細胞
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamamotoToshio
en-aut-sei=Yamamoto
en-aut-mei=Toshio
kn-aut-name=山本敏男
kn-aut-sei=山本
kn-aut-mei=敏男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学歯学部口腔解剖学第一講座
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=8
end-page=14
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1990
dt-pub=199006
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=実験動物としてのショウジョウバエ
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AsadaNobuhiko
en-aut-sei=Asada
en-aut-mei=Nobuhiko
kn-aut-name=浅田伸彦
kn-aut-sei=浅田
kn-aut-mei=伸彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学理学部生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=13
end-page=18
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ビタミンB(12)欠乏ラットの飼育
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KawataTetsunori
en-aut-sei=Kawata
en-aut-mei=Tetsunori
kn-aut-name=河田哲典
kn-aut-sei=河田
kn-aut-mei=哲典
aut-affil-num=1
ORCID=

en-aut-name=YamadaKazuhiro
en-aut-sei=Yamada
en-aut-mei=Kazuhiro
kn-aut-name=山田和弘
kn-aut-sei=山田
kn-aut-mei=和弘
aut-affil-num=2
ORCID=

en-aut-name=WadaMasahiro
en-aut-sei=Wada
en-aut-mei=Masahiro
kn-aut-name=和田政裕
kn-aut-sei=和田
kn-aut-mei=政裕
aut-affil-num=3
ORCID=

en-aut-name=TadokoroTadahiro
en-aut-sei=Tadokoro
en-aut-mei=Tadahiro
kn-aut-name=田所忠弘
kn-aut-sei=田所
kn-aut-mei=忠弘
aut-affil-num=4
ORCID=

en-aut-name=MaekawaAkio
en-aut-sei=Maekawa
en-aut-mei=Akio
kn-aut-name=前川昭男
kn-aut-sei=前川
kn-aut-mei=昭男
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教育学部

affil-num=2
en-affil=
kn-affil=東京農業大学農学部

affil-num=3
en-affil=
kn-affil=東京農業大学農学部

affil-num=4
en-affil=
kn-affil=東京農業大学農学部

affil-num=5
en-affil=
kn-affil=東京農業大学農学部
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=6
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=瀬戸内の森と林―自然林の生育とその生態的機能を考える―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SaigusaMasayuki
en-aut-sei=Saigusa
en-aut-mei=Masayuki
kn-aut-name=三枝誠行
kn-aut-sei=三枝
kn-aut-mei=誠行
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学教養部自然系
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=
article-no=
start-page=22
end-page=26
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=199808
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Flow Injection Analysis for Hydrogen Peroxide in Environmental Waters
kn-title=過酸化水素のフローインジェクション分析の環境水への応用
en-subtitle=
kn-subtitle=
en-abstract=We tried to determine a low-level hydrogen peroxide by using a flow injection analysis (FIA) which was reported in our previous paper. For this purpose, the constituents of the system including the catalytic column were re-examined in detail. As the result, we developed a new system of the FIA which is available for the determination of ppb-order hydrogen peroxide. When hydrogen peroxide spiked in rain-waters(57-944ppb)was analyzed by the FIA, better recovery and reproducibility were attained compared to chemiluminescent analyses. The lower-limit of determination was 10 ppb hydrogen peroxide.
kn-abstract=先に開発した過酸化水素のフローインジェクション分析法（FIA）のシステムや触媒カラムに詳細な検討を加え，ppbレベルの過酸化水素の定量法を開発した。また，本研究で得られたFIAを用いて，57〜944ppbになるように過酸化水素を雨水に添加し，回収実験を行った。その結果，回収率と再現性とも良好で，化学発光法より優れていた。なお，FIAでの検出下限は，約10ppbであった。
en-copyright=
kn-copyright=

en-aut-name=IwadoAkimasa
en-aut-sei=Iwado
en-aut-mei=Akimasa
kn-aut-name=岩藤章正
kn-aut-sei=岩藤
kn-aut-mei=章正
aut-affil-num=1
ORCID=

en-aut-name=MukunoTakashi
en-aut-sei=Mukuno
en-aut-mei=Takashi
kn-aut-name=椋野貴
kn-aut-sei=椋野
kn-aut-mei=貴
aut-affil-num=2
ORCID=

en-aut-name=AkizawaHiromichi
en-aut-sei=Akizawa
en-aut-mei=Hiromichi
kn-aut-name=秋澤宏行
kn-aut-sei=秋澤
kn-aut-mei=宏行
aut-affil-num=3
ORCID=

en-aut-name=MifuneMasaki
en-aut-sei=Mifune
en-aut-mei=Masaki
kn-aut-name=御舩正樹
kn-aut-sei=御舩
kn-aut-mei=正樹
aut-affil-num=4
ORCID=

en-aut-name=SaitoYutaka
en-aut-sei=Saito
en-aut-mei=Yutaka
kn-aut-name=齋藤寛
kn-aut-sei=齋藤
kn-aut-mei=寛
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学自然科学研究科

affil-num=2
en-affil=
kn-affil=岡山大学自然科学研究科

affil-num=3
en-affil=
kn-affil=岡山大学薬学部

affil-num=4
en-affil=
kn-affil=岡山大学薬学部・岡山大学環境管理センター

affil-num=5
en-affil=
kn-affil=岡山大学薬学部・岡山大学環境管理センター
END

start-ver=1.4
cd-journal=joma
no-vol=99
cd-vols=
no-issue=1
article-no=
start-page=97
end-page=113
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The List of Papers Published by Members of the Faculty from January to December 2009.
kn-title=公表学術論文等リスト 2009
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学農学部
kn-aut-sei=岡山大学農学部
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=12
article-no=
start-page=4431
end-page=4441
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Action of KCN and NaN(3) on the Bacterial Metabolism Part 2. The Enzymatic Behaviors of Bacteria in Culture in the Medium loaded with KCN or NaN(3)
kn-title=細菌の代謝に於けるKCN, NaN(3)の作用 第2篇 KCN, NaN(3)添加培地培養菌の酵素的性状
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using the standard strains such as Sh. flexneri 2 a, St. aureus and St. albus that are stocked in our laboratory, the author studied the glucolysis of these bacteria in the course of culture in the medium containing KCN or NaN(3) and also compared the enzymatic behaviors of each kind of bacteria in resting state while being cultured in the medium loaded with KCN or NaN(3). The results are as follows: 1. Both Sh. flexneri 2 a and St. aureus grow well in the medium loaded with 10?? M KCN or NaN(3), and in the medium loaded with 10?? M KCN th growth of St. albus is somewhat impeded but this strain grows well in the medium loaded with 10?? M NaN(3). 2. When KCN or NaN(3) is added to the medium in the course of bacteria culture, the glycolysis tends to be anaerobic; and morever, by the addition of KCN the accumulation of lactic acid increases, while by the addition of NaN(3) the accumulation of acetic acid. 3. On comparing the catalase and peroxidase activities of bacteria cultured in the medium loaded with KCN or NaN(3), both Sh. flexneri 2 a and St. albus lose their catalase and peroxidase activities in the medium loaded with 10?? M KCN or NaN(3); while St. aureus likewise does not show these enzymatic activities in the medium loaded with 10?? M NaN(3), but this strain retains these enzymatic activities to a marked degree in the medium loaded with 10?? M KCN. 4. In these bacteria being cultured in the medium containing KCN the enzymatic activity of lactic acid production from glucose is great, while in these bacteria cultured in the medium containing NaN(3) the acetic acid production from glucose is great.
en-copyright=
kn-copyright=

en-aut-name=TanakaTakao
en-aut-sei=Tanaka
en-aut-mei=Takao
kn-aut-name=田中孝男
kn-aut-sei=田中
kn-aut-mei=孝男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=12
article-no=
start-page=4423
end-page=4429
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Action of KCN and NaN(3) on the Bacterial Metabolism Part 1. The Action of KCN and NaN(3) on Bacteria grown on Plain Agar
kn-title=細菌の代謝に於けるKCN, NaN(3)の作用 第1篇 普通寒天培養菌体に対するKCN, NaN(3)の作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the use of Sh. flexneri 2 a, St. aureus, and St. albus, the standard strains stocked in our laboratory, as the test bacteria, the author studied the effects of KCN and NaN(3) on the enzymatic activity of resting cells grown on plain agar and obtained the following results: 1. Differing as they do in the degree of inhibitory action on the catalase and peroxidase activities according to different bacteria, both KCN(3) show a marked inhibitory action with Sh. flexneri 2 a and a moderate inhibitory action with St. albus. In the case of St. aureus, KCN even in a high concentration does not inhibit the catalase and peroxidase activities, while NaN(3) with the same strain shows a moderate inhibitory action. 2. Likewise the effects of two drugs on the oxygen consumption differ according to different bacteria; namely, KCN with Sh. flexneri 2 a shows a strong inhibitory action; with St. albus a moderate inhibition; and with St. aureus an extremely slight degree of inhibition. Although NaN(3) shows only a slight influence on Sh. flexneri 2 a and St. albus, it shows a marked inhibitory action with St. aureus. 3. As for the aerobic glucolysis of these bacteria both KCN and NaN(3) generally act to interfer complete oxidation, and with the addition of KCN to the culture medium the accumu lation of lactic acid increases on one hand and with NaN(3) that of acetic acid. Even under anareobic condition likewise lactic acid is accumulated increasingly with the addition of KCN while an increase in the accumulation in acetic acid with NaN(3) addition.
en-copyright=
kn-copyright=

en-aut-name=TanakaTakao
en-aut-sei=Tanaka
en-aut-mei=Takao
kn-aut-name=田中孝男
kn-aut-sei=田中
kn-aut-mei=孝男
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=11
article-no=
start-page=4011
end-page=4023
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Bone-Marrow Tissue Culture, the Simple Method of one Design Part 2. The Bone Marrow of Patients with Various Blood Diseases
kn-title=簡易骨髄組織培養法に関する研究 第二編 各種血液疾患々者骨髄に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By performing a series of bone-marrow tissue culture of patients with various blood diseases by simple method the author studied the tissue growht and the wandering velocity of mature neutrophils, and arrived at the following conclusions: 1. In the case of chronic myelogenous leukemia the tissue growth is excellent, but the wandering velocity of mature neutrophils is somewhat decreased. In the cases of acute myelogenous leukemia monocytic leukemia the rate of relative growht is somewhat lower than in the case of normal persons: and the wandering velocity of mature neutrophils shows a markedly low value. The boundary of the growth zone is sharply demarcated, and the cell density index is high, presenting the growth pattern chareteristic to leukemia. 2. In the case of hypoplastic anemia the tissue growth is extremely poor; and the wandering velocity of mature neutrophils is markedly low, showing an increase of fat cells in the explant. 3. In the case of Banti's disease the tissue growth is rather poor, and the wandering velocity of mature meutrophils is low. 4. In the case of essential hypochromic anemia both the tissue growth rate and the wandering velocity of mature neutrophils are identical with those of normal persons. 5. In the case of agranulocytosis the tissue growth is extremely poor, and showing no increase of fat cells in the explant, the treatment with ACTH, however, improves the bone marrow function strikingly. 6. In the case of pernicious anemia the wandering velociyt of mature neutrophils is accelerted by the presence of vitamin B(12) in the medium. These findings by this method of culture coincide almost exactly with those by the conventional method, and it is believed that this method can be widely used in clinics due to its simplicity manipulation.
en-copyright=
kn-copyright=

en-aut-name=OnoYasuzo
en-aut-sei=Ono
en-aut-mei=Yasuzo
kn-aut-name=小野安三
kn-aut-sei=小野
kn-aut-mei=安三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=10
article-no=
start-page=3765
end-page=3772
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Vital Staining of Cells in the Fluid obtained by Puncture from Animals, mainly by Means of Tissue Culture Part 3. Cells in the Pleural Fluid, especially Phagocytes
kn-title=動物穿刺液細胞の主として組織培養法を応用せる生体染色の研究 第三編 胸水細胞特に食細胞に就て 附:全編の総括
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using pleural fluid of mice and rabbits the basic-dye staining was carried out by means of tissue culture with a special emphasis on phagocytes, and these were compared with the phagocytes in ascites. The following are the results of the present study: 1. The basic type in the vital staining findings of the phagocytes in pleural fluid coicides exactly with those of the phagocytes in ascites. Furthermore, on taking other findings into consideration, it is certain that these two are identically the same kind of cells and they are near-relatives of monoctyes. 2. However, phagocytes in pleural fluid tend to show a more marked neutral-red rosette formation than the phagocytes in ascites, while on the contrary the degree of neutralred stain, the time retaining the stain and also the time retaining Janus-green stain are inferior to those of the phagocytes in ascites; and this phenomenon seems to be due to the immaturity of the phagocytes in the pleural fluid.
en-copyright=
kn-copyright=

en-aut-name=FukudaMasao
en-aut-sei=Fukuda
en-aut-mei=Masao
kn-aut-name=福田正夫
kn-aut-sei=福田
kn-aut-mei=正夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=10
article-no=
start-page=3753
end-page=3763
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Vital Staining of Cells in the Fluid obtained by Puncture from Animals, mainly by Means of Tissue Culture Part 2. The Property of Phagocytes
kn-title=動物穿刺液細胞の主として組織培養法を応用せる生体染色の研究 第二編 食細胞の本態に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With the purpose to pursue the property of phagocytes in ascites observations were carried on vital stainings of the ascites cells at the time of stimulation and after removal of the greater omentum as well as vital stainings of subcutaneous histiocytes and monocytes in the bone marro and blood; and also studied vital staining of the ascites cells stained after a certain period of culture. 1. At the time of stimulation the newborn cells in ascites are weak and immature, possessing characteristics very much like those of monocytes, and pre-existing phagocytes reveal an advanced degeneration. 2. In the case where dye was added in the course of culture, it has been confirmed that those cells transformed like fibrocytes, fibroblasts or histiocytes are none other than one of modified forms of phagocytes. 3. By excision of the greater omentum, it has been observed that phagocytes mature in the steps of a small type ? intermediate type ? large type. Moreover, it has been verified that phagocytes are derived from milky spots on the greater omentum. 4. After precise scrutiny of subcutaneous histiocytes and monocytes in the bone marrow and blood, the similarity of phagocytes to monocytes as already stated in Part 1 has been verified. From these data it is bilieved that ascites phagocytes are either monocytes or the cells very closely related to monocytes.
en-copyright=
kn-copyright=

en-aut-name=FukudaMasao
en-aut-sei=Fukuda
en-aut-mei=Masao
kn-aut-name=福田正夫
kn-aut-sei=福田
kn-aut-mei=正夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=10
article-no=
start-page=3743
end-page=3752
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19581031
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Vital Staining of Cells in the Fluid obtained by Puncture from Animals, mainly by Means of Tissue Culture Part 1. A Study on Cells in Ascites, especially on Phagocytes, in Mice and Other Various Animals
kn-title=動物穿刺液細胞の主として組織培養法を応用せる生体染色の研究 第一編 マウス他各種動物の正常時腹水細胞特に食細胞の所見
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author performed basic-dye vital staining of ascites cells, especially phagocytes, of mice, rats, rabbits, cats, dogs and chickens or acidic-dye vital staining by injecting dyes into the peritoneal cavity of these animals, by means of tissue culture in both cases, and obtained the following results: 1. In the cases of basic-dye vital staining phagocytes present a neutral red rosette formation as their basic picture; and mitochondria are distributed around the nucleus, revealing an appearance much like a moncyte; and the higher the animal is the more pronounced is this tendency. 2. In the acidic-dye vital staining as applied to mice, at each additional injection of the dye the degree and percentage of staining cells increase step by step as if it indicated an increase in the degeneration of cells with each injection. Although these cells do not demonstrate characteristics in so high a degree as in the case of basic dyes, they, nevertheless, present essentially a staining picture resembling the findings on monocytes, considering these cells prior to degeneratiou. From these findings it may be said that the picture of vital staining in the ascites cells resembles that of monocytes.
en-copyright=
kn-copyright=

en-aut-name=FukudaMasao
en-aut-sei=Fukuda
en-aut-mei=Masao
kn-aut-name=福田正夫
kn-aut-sei=福田
kn-aut-mei=正夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=2-2
article-no=
start-page=805
end-page=813
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1959
dt-pub=19590228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Utilization of Aureomycin as the Inhibitor in the Study of Bacterial Glucose oxidation. Part 2. Mechanism of Aureomycin inhibition
kn-title=細菌のグルコース酸化に於ける阻害剤としてのオーレオマイシンの利用 第2篇 オーレオマイシン阻害の機序
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using the standard straine of Sh. flexneri 2a and St. aureus, the mechanism of AM inhibition on the c-source oxidation of bacteria are studied and the following results ore obtained. 1. AM inhibition of glucose, lactate or pyruvate oxidation can be restored by addition of Fe(++) or Fe(+++), especialy in th case where Fe(++) or Fe(+++) added to cells before addition of AM. 2. AM does not inhibit so markedly the oxygen uptake of the cells grown on the medium added KCN or NaN(3) and adapted to these inhibitors. From these results, it seems that AM inhibits the enzymatic retions by catching Fe(++) the other metal ions necessary to the enzyme actviities. 3. AM inhibition can not be restored by thionine, and AM does not inhibit catalase and peroxidase reaction.
en-copyright=
kn-copyright=

en-aut-name=IzumiharaMitsue
en-aut-sei=Izumihara
en-aut-mei=Mitsue
kn-aut-name=泉原充衛
kn-aut-sei=泉原
kn-aut-mei=充衛
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=7
article-no=
start-page=2607
end-page=2618
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cyto-architectonic and histochemical studies of the caudata nucleus in cat's brain with special reference to convulsion Part �U Histochemical study of choline-esterase in areas of the caudate nucleus of cat's brain with convulsion
kn-title=猫脳尾状核の細胞構築学的研究ならびに痙攣時の組織化学的研究 第2編 実験的痙攣猫脳尾状核各分野のコリンエステラーぜ（ChE）に関する組織化学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ten per cent metrazol solution was experimentally injected in cats and the changes of choline-esterase (ChE) at the maximum stage of convulsion was histochemically investigated by Koelle modification. 1) The ChE of nerve cells mostly increased in normal cases relatively in peripheral part of protoplasma, while in convulsion cases it was considered to be even in central part of protoplasma. 2) ChE is increased in each area of the caudate nucleus by convulsion. 3) The increase is especially remarkable in the large cells of the caudate nucleus. 4) The dorsolateral side of the caudate nucleus (Cd., Cm.) has more increase of ChE than the ventromedial side by convulsion, and Cm. has the most increase, then in the order of Cd., Cl. and Cv. to the least. 5) In cases without convulsion, there is no difference of ChE distribution among these areas, and even the large cells have no marked increase of ChE.
en-copyright=
kn-copyright=

en-aut-name=NishiwakiKorenobu
en-aut-sei=Nishiwaki
en-aut-mei=Korenobu
kn-aut-name=西脇惟信
kn-aut-sei=西脇
kn-aut-mei=惟信
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=7
article-no=
start-page=2517
end-page=2524
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Eosinophils in the Bone-Marrow Tissue Culture Part 2. Observation on the Motility of Eosinophils in the Bone-Marrow Tissue Culture of the Sternum of various Patients with Eosinophilia
kn-title=骨髓体外組織培養による好酸球に関する研究 第2編 各種好酸球増多症患者の胸骨骨髓培養における好酸球運動の観察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By performing bone-marrow tissue culture (simple method devised in our laboratory) of the sternum in normal person, patients wish anchylostomiasis and with bronchial asthma, the author observed the pattern of movement and wandering velocity of these eosinophils and obtained the following results: 1. Patterns of movement of eosinophils in the human bone marrow have been newly classified. 2. Among the eosinophils of human anchylostomiasis there are ones that show a peculiar pattern of movement, Type IB, which may be considered to be the acceleration in the ability of retraction of the exoplasm. In addition, a picture of scattered granules can often be recognized. The wandering velocity of eosinophils in this disease is markedly accelerated, showing the veloeity somewhat superior to that of neutrophils. 3. In the eosinophils of bronchial asthma there are cells suggesting an abnormally accelerated adhesive property, for example, possessing abnormally distended tail or filamentous tail with many branches; and also granule-movement is quite active. As can be seen from the above findings, there are eosinophils in anchylostomiasis and bronchial asthma, that show the pattern of movement that can not be observed in those of normal persons, and therefore, it has been clarified that those eosinophils of the bone marrow in patient not only multiply in number but also their pattern of movement undergoes morphological changes simultaneously.
en-copyright=
kn-copyright=

en-aut-name=InoueMasakatsu
en-aut-sei=Inoue
en-aut-mei=Masakatsu
kn-aut-name=井上正勝
kn-aut-sei=井上
kn-aut-mei=正勝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=7
article-no=
start-page=2369
end-page=2379
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Bone Marrow Function and the Iron Metabolism Part 1. On the Movement of Stored Iron in Accordance with the Bone Marrow Function
kn-title=骨髄機能と鉄代謝に関する研究 第一編 骨髄機能の変化に対する貯蔵鉄の動態について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The relationship between stored iron and hematopoietic function of the bono marrow was studied in rabbits under various conditions by means of radioactive iron (Fe(55)). The quantitative fractionation of tissue iron was performed according to the method described by Yoneyama and Konno. In normal rabbits, radioactive iron, intravenously injected in tracer amounts, distributed in P�T (probably contains hemosiderin) as well as P�U (proved to have come really from ferritin) in an almost epual amount. By mobilization and utilization, however, a preponderance of P�U over P�T was recognized. In rabbits with anemia due to blood loss, the movement of administered radioactive iron was accelerated and specifc activity of P�V in bone marrow markedly increased. In rabbits suffered from disturbances on hematopoietie function, such as X-ray irradiation and collargol injection, on the contrary, the movement of iron was slow and P�V in bone marrow came to the retetion. In rabbits suffered from X-ray irradiation after bleeding, it was revealed that P�V in bone marrow was most available for heme synthesis in three fractions. In accordance with the procedures which caused the hematopoietic disturbances, the distribution of non-hemin iron in the spleen showed the same pattern as in bone marrow, i.e., at 24 hours after injection of radioactive iron P�V was markedly increased and P�U was decreased.
en-copyright=
kn-copyright=

en-aut-name=ShiomiFumitoshi
en-aut-sei=Shiomi
en-aut-mei=Fumitoshi
kn-aut-name=塩見文俊
kn-aut-sei=塩見
kn-aut-mei=文俊
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=4
article-no=
start-page=1315
end-page=1329
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Tissue Culture of the Bone Marrow in Various Animals Part 3. Vital Staining of Bone Marrow Cells
kn-title=各種動物の骨髄体外組織培養 第3編 骨髄細胞の生体染色に就て 附,全編の総括
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=With bone-marrow tissue culture of various animals, namely, mammals (mice, albino rats, guinea pigs, cats and dogs), birds (chicken and pigeons), and cold blooded animals (frogs), the author studied neutral red vital staining of bone marrow cells and arrived at the following conclusions. 1) In the neutrophilic series, granules of young immature cells have a strong affinity to neutral red, and mature neutrophils are stained in intermediate degree. The stained granules tend to fuse with one another and grow larger alog with the lapse of time. 2) Practically all eosinophils are stained light red, while basophilocytes are all stained deep red. Eosinophils of birds show some reluctancy to be stained. Monocytes on the whole are stained in intermediate degree and they are usually arranged in the rosette formation, and those in birds and frogs are arranged in a typical fashion, Lymphocytes, megakaryocytss thrombocytes and spindle cells all clearly show neutral red granules. 3) As for the stainability of neutrophils and pseudo-eosinophils with respect to the passing of time in birds, it is generally highest in pseudo-eosinophils and also the average rate of staining is higher than that of mammals, but their color fades more quickly. In neutrophils of frogs the rate of this color-fading is rather slower than that of warm-blooded animals.
en-copyright=
kn-copyright=

en-aut-name=SuenagaTaizo
en-aut-sei=Suenaga
en-aut-mei=Taizo
kn-aut-name=末永泰三
kn-aut-sei=末永
kn-aut-mei=泰三
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=73
cd-vols=
no-issue=7-9
article-no=
start-page=589
end-page=593
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1961
dt-pub=19610930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Phagocytosis of Leucocytes, especially of Neutrophils, for Carbon Particles in Acatalasemia and Various Oto-rhino-laryngological Patients
kn-title=無カタラーゼ血液症及び諸種耳鼻咽喉科疾患々者に於ける白血球（特に好中球）の墨粒貪喰能に就て
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Phagocytosis of leucocytes in the blood of acatalasemia for carbon particles was investigated by means of the slide method, using the blood of healthy people and various oto-rhino-laryngological patients as controls. Phagccytosis in neutrophils was classified into five degrees from negative to 3 positives (-, ±, +, ++, +++), giving them values of 0, 1, 2, 3 and 4 respectively, according to the degrees of phagocytosis. The mean values counted by this method were as follows; 1) Number of healthy people examined was seven and the mean value was 2.55. 2) Nineteen otorhinolaryngological patients were examined and their mean value proved to be 2.50. The mean value of thirteen out of these nineteen patients was 2.54, except six cancer patients. Three out of these six cancer patients had been treated with radium and the mean value did not differ from that of healthy people, while three X-ray treated patients showed the mean value of 2.31. 3) Number of acatalasemia patients was two and their mean value 2.53. As far as the present experiment is concerned, there appears no significant difference in the degree of phagocytosis in leucocytes for carbon particles in the groups examined except X-ray treated cancer patient group, who showed lower mean value.
en-copyright=
kn-copyright=

en-aut-name=OritaYozo
en-aut-sei=Orita
en-aut-mei=Yozo
kn-aut-name=折田洋造
kn-aut-sei=折田
kn-aut-mei=洋造
aut-affil-num=1
ORCID=

en-aut-name=TamuraMinoru
en-aut-sei=Tamura
en-aut-mei=Minoru
kn-aut-name=田村実
kn-aut-sei=田村
kn-aut-mei=実
aut-affil-num=2
ORCID=

en-aut-name=MoritaYoshio
en-aut-sei=Morita
en-aut-mei=Yoshio
kn-aut-name=森田善雄
kn-aut-sei=森田
kn-aut-mei=善雄
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=3
article-no=
start-page=765
end-page=778
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1958
dt-pub=19580331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Influence of Roentgen-Rays on the Tissue Respiration and the glycolytic action in Carcinoma of the Cervix
kn-title=子宮腟部癌組織呼吸並びに解糖作用に及ぼすレントゲン線の影響に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author estimated by Warburg's manometer, the tissue metabolism of normal (10 cases) and carcinomatus (73 cases) patients who were hospitalized in Okayama University Hospital. The influence of Roentgenrays on cancer tissue was also studied after irradiating (900r, 1800r 2700r and 3600r each) on them, and the relation between its clinical or histological findings and cancer tissue metabolism rate or metabolic X-ray sensitivity. Following results were obtained: 1) Tissue metabolism of the normal cervix is relatively high in the respiration rate, but low in the glycolytic action. 2) Tissue metabolism of non-treated uterine cancer is slightly higher in the respiration rate and notably higher in the glycolysis, comparing to those of the normal uterine tissue. 3) Influence of X-rays on the cancer tissue metabolism: the respiration rate is markedly suppressed and becomes lower than that of the normal tissue by the irradiation described above, and the glycolytic action is not suppressed by the irradiation of 900 r, but is suppres sed, not less than the rate of the normal tissue, by irradiation of over 1800 r. 4) Relation between the non-treated cancer tissue metabolisn and its clinial and histological findigs. The metabolism rates increase in following cases; advanced cases classified clinically, I type in Nagase's classification, cases after menopause and large -tumor-bearing group. 5) Relation between the metabolic X-ray sensitivity and the clinical and histological findings: In creases of X-ray sensitivity are observed in following cases; younger age group, �W-�Y type in Mandelstamm's method, cases schowing intersive changes in the tissue and increasing T.P.T-positive cells, and spinous-cell group in Martzloff's classification. 6) Metabolism suppressing rate, i.e. metabolic X-ray sensitivity is closely related to the histomorphological findings, and is thought to be one of the important methods to determine the X-ray sensitivity.
en-copyright=
kn-copyright=

en-aut-name=MitsuiHideo
en-aut-sei=Mitsui
en-aut-mei=Hideo
kn-aut-name=光井英夫
kn-aut-sei=光井
kn-aut-mei=英夫
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山医大学部産婦人科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=11-12
article-no=
start-page=2003
end-page=2016
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19601231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cytological Studies on Human Ascites by Means of Vital Staining and Carbon Particle Phagocytosis with Triphenyl Tetrazolium Chloride (T.P.T.) Reaction Part 2. A Study on Tumor Ascites
kn-title=生体染色並びに墨粒貪喰による人腹水の細胞学的研究 附T.P.T（Triphenyl Tetrazolium Chloride）反応 第2編 腫瘍性腹水に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Vital observations were carried on with 33 examples of tumor ascites in tissue culture by means of vital staining and carbon particle phagocytosis and also cytological investigations were conducted with T.P.T reaction. With further studies on the nature and cell composition of ascites the following results were obtained. 1. The average specific gravity of ascites has been found to be 1008-1027, the average protein content 3.36 g/dl., the average cell count 584/?, and the composition of cells reveals the increase in the appearance of neutrophils, serous cells and signet ring cells among tumor cell, and these are characteristics of the ascites. By dividing these into two groups, namely one ascites group with the appearance of less than 5 per cent of tumor cells and other with the tumor cell appearance of over 20 per cent, the characteristic traits of ascites might be understood still better. 2. The confirmation of tumor cells and tumorous signet ring cells is taken as a direct indication and cytological peculiarities of other cells are considered to be an indirect indication. 3. As for the direct indication, tumor cells and tumorous signet ring cells are generally stained well with vital staining, and the stainability of the group 2 is better than the group 1. However, that of carbon particle phagocytosis is negative. 4. Cytological peculiarities of their own can be recognized in the vital observations of various cells such as those of adenoma, simple cancer, scirrhus, colloid cancer, hepatoma, coelothelioma. 5. As for the indirect indication, coarse and large granules of various cells can be recognized, and also the acceleration of neutral red staining, phagocytic ability of phagocytes and the appearance of Janus green specific granules as well as enhancement of the neutral red stainability of neutrophils and serous cells can be observed. 6. In T.P.T. reaction tumorous ascites is always positive whereas in other ascites they are negative to this test and therefore, this point proves to be a useful indirect indication. 7. For the distinction between tumorous signet ring cells and phagocytic signet ring cells, both possess their own characteristics of original cells and carbon particle phagocytosis of the former in negative, while the latter is positive.
en-copyright=
kn-copyright=

en-aut-name=KomatsubaraToshishige
en-aut-sei=Komatsubara
en-aut-mei=Toshishige
kn-aut-name=小松原利繁
kn-aut-sei=小松原
kn-aut-mei=利繁
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=5-7
article-no=
start-page=1407
end-page=1422
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600730
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Catalase Activity of Babteria
kn-title=細菌のカタラーゼ活性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Part �T Effect of Added Substance to the Media on Catalase Activity Using Sh. flexneri 2 a and Sal. typhi 57 as test organism, the author studied the effect on calase activity of bacteria by adding a certain kind of substance into culturing media, the following results were obtained. 1) The catalass activity was not influenced by the addition of lactate, pyruvate or succinate into media, but was decreased by addtion of glucose. 2) A marked decrease in the catalase activity was observed by addition of KCN or NaN(3), in dilution of 1/3×10(-4)M; whereas no change in other enzyme activity was observed by the addition of these substance. 3) The addition of α, α'-dipyridyl or oxine, in dilutions of 20-30 mg/L, showed marked decrease in oxidative ability of bacteria of pyruvarte, and the decrease in catalase activity was simultaneously observed only in Sh. flexneri. Part �U Oxidation of glucose and alanine by catalase deficient bacteria Using Sh. flexneri 2 a, Sh. dysenteriae 4 and D. pneumoniae �U, the author studied the enzymatic properties of the catalase active and inactive bacterial cells mentioned above by means of volumetric studies of glucose and alanine oxidation and also studied the effect of these cells on normal or acatalasemic erythrocytes, especially on hemoglobin of the erythrocytes. The following results were obtained. 1) As the cells of Sh. flexneri 2 a grown on KCN or NaN(3) added nutrient agar media was lacking catalase activity, the organism could'nt decompose H(2)O(2) produced throuth the course of glucose or alanine metabolism. So formed pyruvate by the metabolism was oxidized by H(2)O(2) inversely. And hemoglobin was oxidized to methemoglobin, when erythrocytes were added to the reaction media. 2) Sh. dysenteriae 4 is failing catalase and the production of H(2)O(2) was not detected at all or only scantily on the cells grown on any kind of media. 3) D. pneumoniae �U is also failing catalase, but the production of H(2)O(2) was remarkably high.
en-copyright=
kn-copyright=

en-aut-name=AkiyamaKenji
en-aut-sei=Akiyama
en-aut-mei=Kenji
kn-aut-name=秋山健二
kn-aut-sei=秋山
kn-aut-mei=健二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=4-6
article-no=
start-page=367
end-page=388
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1963
dt-pub=19630630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=�U. Effects of Chlorpromazine on the Function and　metabolism of the Perfused Cat Brain
kn-title=�U Chlorpromazineの灌流ネコ脳髄に対する作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The cat brain was perfused through the isolated cerebral circulation by the modified Geiger & Magnes' methode, and the effects of Chlorpromazine (CP) on cerebral blood flow (CBF), blood pressure (BP), carbohydrate metabolism and electroencephalogram (EEC) were investigated by the use of the brain perfusion methode. The results were as follows. 1) The CBF was increased by the administration of small doses of CP while no significant changes in CBF were showed with large doses of the drug, and it is suggested that this finding is explainable on the basis of inhibition of the brain metabolism caused by the dosage. 2) BP kept intact or dropped case by case with CP, and it is considered that this difference may be due to individual characteristics of the cats, doses to be applied, degrees of operation etc.. When BP dropped in the case of perfusion, it means a central vasomotoric action. BP dropped to a level on the dosage best suited to individual, morever, its central vasodilatatoric action was more persistent and not to be influenced by the subsequent administration of CP, while the direct effect on dilating the cerebral blood vessels was transient and appeared similarly by the subsequent application of CP. 4) With a small dosage of CP, a tendency toward increase of the oxygen and glucose consumption, and most remarkable increase of the lactic acid liberation were observed. On the other hand, oxygen and glucose consumption, and lactic acid liberation were all diminished by the application of large doses of CP, and particularly, both the oxygen consumption and the lactic acid liberation was markedly diminished. And at the same time, I explained a little opinion about those alterations in metabolism. 5) The changes in EEGs of neocortex, paleocortex and archicortex were observed by the administration of CP. Namely, EEG of neocortex showed slowing of frequency and increase in amplitude with CP, and in hippocampus the regularity of hippocampal regular slow waves was lost and there appeared fast waves, contrarily, amygdala showed no change after the administration of CP and low voltage fast waves from beginning to end.
en-copyright=
kn-copyright=

en-aut-name=IchiyamaTakuji
en-aut-sei=Ichiyama
en-aut-mei=Takuji
kn-aut-name=市山卓爾
kn-aut-sei=市山
kn-aut-mei=卓爾
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部神経精神医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=76
cd-vols=
no-issue=10
article-no=
start-page=587
end-page=605
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1964
dt-pub=19641030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on Leukemia in The C58 Strain of Mice Part 1. Hematological and histological studies of normal mice, spontaneous and transplanted leukemia mice
kn-title=C58マウス白血病の研究 第�T編 正常マウス，自然発生白血病及び移植白血病の血液学的組織学的研究並びに白血病ウイルスの電顕的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hematological and cytological studies, including peripheral blood counting, blood picture, myelogram, impressed preparation of spleen and lymph node, and phase contrast microscopic and electron microscopic observations of leukemic cells were performed on the high leukemic strain C58 mice. In the present observation, 61.4% of C58 mice developed leukemia spontaneously after the latent periods varing from 4 to 19 months. In non-leukemic mice, blood counting, peripheral-blood picture and myelogram did not show any significant change throughout the each age groups, but lymphocyt/neutrophile ratio decreased gradually after the age of 6 month. Old mice above 12 months of age showed a slight hypochromic anemia and relative neutrophilia. Most of the spontaneous leukemia occurred after the age of 6 month and 61.4% of them occurred between the age of 12 and 16 month. All of the spontaneous leukemias observed in this strain were lymphatic type. White cell count ranged from 4,500 to 225,000, averaging 109,600 with 47.2% lymphoblasts in average. Marked anemia and thrombocytopenia were present. Myelograms showed slight or moderate lymphoblastic infiltrations, but impressed preparation of spleen and lymph node always contained lymphoblasts over 90%. Morphological characteristics of the lymphoblast observed in spontaneous leukemia were narrow basophilic cytoplasm, large nucleus with a few deep indentations, coarse chromatin net work and nucleoles of vague chromatin borders. Phase contrast microscopy of lymphoblast showed nucleal indentations clearly and bright cytoplasm with a few rod-shaped mitocondrias in the Golgi area. Electron microscopic observations of lymphoblast also revealed the characteristic indentations of the nucleus. Spontaneous leukemia could be transplanted easely to the adult C58 mice by cell graft. A transplanted line named OHS-LL, No 1 is being maintained serially up to present. Serially transplanted leukemia mice often showed remarkable myeloid reaction and died after 7-8 days after cell graft. Blastic cells became to show atypical form suggesting of much more primitive and malignant character than that of the original leukemia by serial transplantations. Electron microscopic observations of lymph node and spleen of spontaneous leukemia revealed the presence of numerous virus particles located extracellularly. These particles were morphlolgically identical with the C particle observed in various other leukemic mice.
en-copyright=
kn-copyright=

en-aut-name=SuzukiShinya
en-aut-sei=Suzuki
en-aut-mei=Shinya
kn-aut-name=鈴木信也
kn-aut-sei=鈴木
kn-aut-mei=信也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科
END

start-ver=1.4
cd-journal=joma
no-vol=79
cd-vols=
no-issue=3-4
article-no=
start-page=153
end-page=166
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1967
dt-pub=19670430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Tissue Culture of Spleen Part 3. On the Clinical Application
kn-title=脾臓組織培養に関する研究 第3編 臨床応用について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The author employed securely laparoscopy in performing direct vision splenic biopsy, cultured the biopsied human splenic tissue using the clinical tissue culture method of spleen, and obtained the following conclusions. 1) In the lighting observation of spleen using laparoscopy , about half the number of both leukemia and Banti's disease showed change in the character of surface , namely, color,
hardness, enlargement, atrophie, unevenness and adhesion. In the histological observations of biopsied splenic tissue, although all cases of lekemia showed the infiltration of leukemic cells, the determination of infiltrated cells in an acute lymphocytic leukemia and two cases of monocytic leukemia was difficult. In adout 70 per cents of Banti's disease the histological observations which suspected this disease were shown. In the splenogram of all cases of leukemia, the infiltration of various leukemic cells was seen respectively, and the determination of infiltrated cells was possible. While in the splenogram of Banti's disease no significant pathological findings were obtained. 2) In the splenic tissue culture of acute leukemia including monocytic leukemia, the boundaries of the growrh zone were well-defined and clear-cut, the cell density increased markedly and cells in the growth zone were mostly lymphoblasts and young lymphocytes in the case of acute lymphocytic leukemia, myeloblasts and immature granulocytic cells in the case of myelogenous leukemia, and monoblasts and promonocytes in the case of monocytic leukemia. 3) In chronic myelogenous leukemia double growth zone was not shown but the similar pattern to that of acute leukemia was seen. 4) In leukemoid reaction the pattern of splenic tissue growth was similar to that of normal human spleen, however in the growth zone numerous myelogenous cells, many of which were immature, were seen. 5) In Banti's disease the growth was somewhat reduced. In the terminal stage, splenic reticulum cells and fibroblasts tended to increase. 6) In aplastic anemia the growth pattern was similar to that of normal spleen, howevrer a few immature myelogenous cells were always found in the rowth zone. 7) In chronic Werlhof's disease the growth pattern gshowed that of normal spleen, except that many megakaryocytes with diminished function appeared in the growth zone. 8) In leukemic reticuloendotheliosis the growth pattern resembled that of acute lekemia. The growth zone was composed of the same lymphoblastoid cells as found in the peripheral blood and larger young cells. 9) In infection the growth pattern resembled the normal but its growth was remarkable and mature neutrophils were increased markedly. From these results the author thought that the clinical tissue culture method of spleen, when it was performed in company with the clinical tissue culture method of bone marrow, had important clinical significance for making clear various blood diseases and other diseases mit splenomegaly.
en-copyright=
kn-copyright=

en-aut-name=ShimazakiKoichi
en-aut-sei=Shimazaki
en-aut-mei=Koichi
kn-aut-name=島崎孝一
kn-aut-sei=島崎
kn-aut-mei=孝一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=84
cd-vols=
no-issue=3-4
article-no=
start-page=33
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1972
dt-pub=19720430
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=STUDIES ON THE CATALASE IN HYPOCATALASEMIC AND ACATALASEMIC BLOOD BY IMMUNOFLUORESCENT ANTIBODY AND ON THE OXIDATION OF HEMOGLOBIN IN THESE BLOOD
kn-title=低カタラーゼ血液症および無カタラーゼ血液症の蛍光抗体法による研究およびヘモグロビン酸化に関する研究 第2編 Choleglobin生成とカタラーゼ量について―特に正常血,低カタラーゼ血,無カタラーゼ血を中心に―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The oxidation of hemoglobin with ascorbic acid gives formation to choleglobin. In these reaction processes, catalase decomposes H(2)O(2) and inhibits choleglobin formation. In this experiment, we compared the degree of hemoglobin oxidation in human acatalasemic blood to that in human hypocatalsemic and normal blood. Results obtained were as follows: Choleheme increased with decrease in protoheme at the initial stage. After a certain time of the reaction, however, the formation of choleheme remained stationary and the formation of choleglobin was lower in the hypocatalasemic blood than the acatalasemic blood and in the case of the normal blood it was the lowest.
en-copyright=
kn-copyright=

en-aut-name=SetoTakashi
en-aut-sei=Seto
en-aut-mei=Takashi
kn-aut-name=瀬戸卓
kn-aut-sei=瀬戸
kn-aut-mei=卓
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1297
end-page=1308
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Participation of superoxide generating system, superoxide dismutase and vitamin E in the radiation hazards
kn-title=放射線障害におけるスーパーオキサイド生成系(O(2))とスーパーオキサイド・ディスムターゼ(SOD)及びビタミンEの関与に対する考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In relation to the mechanism by which hemolysis was induced in radiated human erythrocytes in vitro, several inducements of membrane lipid peroxidation and protective effects of V.E and SOD were investigated. Results obtained were as follows: (1) K(+)-release from erythrocytes was accelerated by radiation prior to hemolysis. These accelerated hemolysis and K(+)-release were protected remarkably by V.E and evidently by SOD. (2) Mitochondrial Fe(2+) induced and Fe(3+)-O(2) generating system -ADP induced lipid peroxidation, and microsomal O(2) generating system -induced lipid peroxidation were also protected by V.E and SOD. (3) Radiation of X-ray or (60)Co γ-ray accelerated lipid peroxidation of liver homogenate, microsome and liposome. Some of these accelerated lipid peroxidations were protected effectively by V.E and SOD. These results suggest that O(2) and/or OH. generation by radiation induces of membrane lipid peroxidation, which leads deterioration of membrane resulting in the change of ion permeability and then hemolysis.
en-copyright=
kn-copyright=

en-aut-name=AonoKaname
en-aut-sei=Aono
en-aut-mei=Kaname
kn-aut-name=青野要
kn-aut-sei=青野
kn-aut-mei=要
aut-affil-num=1
ORCID=

en-aut-name=YamamotoMichio
en-aut-sei=Yamamoto
en-aut-mei=Michio
kn-aut-name=山本道夫
kn-aut-sei=山本
kn-aut-mei=道夫
aut-affil-num=2
ORCID=

en-aut-name=IidaSosuke
en-aut-sei=Iida
en-aut-mei=Sosuke
kn-aut-name=飯田荘介
kn-aut-sei=飯田
kn-aut-mei=荘介
aut-affil-num=3
ORCID=

en-aut-name=UtsumiKozo
en-aut-sei=Utsumi
en-aut-mei=Kozo
kn-aut-name=内海耕慥
kn-aut-sei=内海
kn-aut-mei=耕慥
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院中央放射線部

affil-num=2
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部癌源研究所生化学部門
END

start-ver=1.4
cd-journal=joma
no-vol=87
cd-vols=
no-issue=5-6
article-no=
start-page=543
end-page=548
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1975
dt-pub=19750630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Denaturation of Catalase in Livers by SDS Treatment
kn-title=肝カタラーゼのSDSによる変性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=When the crystalline beef liver catalase was treated with SDS (sodium n-dodecyl sulfate) or LIS (3, 5-diiodosalicylic acid lithium salt) which is a kind of the anionic surfactant, its catalase activity dwindled and disappeared at last, and its peroxidatic activity was exhibited. It was found by the ultracentrifugal analysis that the molecule of beef liver catalase treated with SDS splited into two subunits with sedimentation constants of about 10S and 2S. The same phenomena as mentioned above were compared in the crude catalase extracts of livers from normal mice and acatalasemia mice. In the crude catalase extracts from both mice, catalase activities dwindled and disappeared in the same way and peroxidatic activities appeared if treated with SDS. But peroxidatic activity of acatalasemia liver extract was higher than that of normal liver extract. It seems that the liver catalase in acatalasemia mouse is more labile by SDS treatment than that in normal mouse, resulting in showing the conformational changes of catalase molecule in acatalasemia mouse liver.
en-copyright=
kn-copyright=

en-aut-name=MizugakiJunko
en-aut-sei=Mizugaki
en-aut-mei=Junko
kn-aut-name=水垣順子
kn-aut-sei=水垣
kn-aut-mei=順子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=タバコ培養細胞におけるプロリンとベタインによるカドミウムストレスの軽減
kn-title=Mitigation of Cadmium Stress by Exogenous Proline and Glycinebetaine in Tobacco Cultured Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=IslamMohammad Muzahidul
kn-aut-sei=Islam
kn-aut-mei=Mohammad Muzahidul
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=水溶性金属八臭素化ポルフィリン及びその固定化担体の分析学的応用に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MoriKatsuya
en-aut-sei=Mori
en-aut-mei=Katsuya
kn-aut-name=森勝也
kn-aut-sei=森
kn-aut-mei=勝也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=9-10
article-no=
start-page=1221
end-page=1243
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1977
dt-pub=19771030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A cytological study on the caveolated cells of the rat and the human digestive organs
kn-title=ラットおよびヒトにおけるcaveolated cellの細胞学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Firstly, the ultrastructure of the caveolated cells on the rat bile duct were examined by a transmission and a scanning electron microscope. Next, the author seeked whether caveolated cells were present or not in the human digestive organs. Lastly, functional study of the caveolated cells on the rat bile duct were investigated using horseradish peroxidase and pilocarpine. Then the facts mentioned below were clarified. 1) Caveolated cells in the rat bile duct were found most densely at the divelticulum-like recesses but on the luminal surface except this recesses caveolated cells were found partly densely and partly sparsely. 2) On the rat, the straight filaments of the caveolated cells of the bile duct were less developed than that of the digestive tract, but circular filaments were more developed than that of the digestive tract. 3) The apical vesicles of the caveolated cells were revealed to have no communication to outer lumen of these cells using lanthanum as a tracer. 4) The caveolated cell-like cells were found in the mucosa of a human colon. But these cells could not be identified clearly with caveolated cells. Because the vesicles were scanty and small in size and the inner substance was relatively electron opaque. 5) After intraluminal injection of peroxidase into ligated segments of bile duct, the marker was found within the apical vesicles. But it was not uncertain whether pre-existing apical vesicles had taken up the marker or vesicles containing the marker were formed newly by pinocytosis. 6) After intraperitoneal injection of pilocarpine, the supranuclear vesicles began to expand and the vesicles with granules moved toward the free surface suggesting eruption or diacrine secretion. And frequently apocrine secretion was also observed. In conclusion, the author supposes that caveolated cell may have both absorptive and secretory functions and this type cells may present in human digestive tract.
en-copyright=
kn-copyright=

en-aut-name=OkudaTakehiko
en-aut-sei=Okuda
en-aut-mei=Takehiko
kn-aut-name=奥田武彦
kn-aut-sei=奥田
kn-aut-mei=武彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=94
cd-vols=
no-issue=7-8
article-no=
start-page=629
end-page=632
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1982
dt-pub=19820830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The uptake of metallic mercury by peroxidase in animals and its inhibition by L-dopa.
kn-title=動物性ペルオキシダーゼによる金属水銀取り込みとL-dopaによるその抑制作用について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The uptake of metallic mercury by lactoperoxidase was measured. The results are described as follows: (1) The uptake of metallic mercury by lactoperoxidase in the presence of hydrogen peroxide was 10 times higher than that in the absence of hydrogen peroxide. (2) The uptake of metallic mercury by lactoperoxidase in the presence of L-dopa in the Lact. -H(2)O(2) system decreased, and decreased further as the concentration of L-dopa increased. (3) The uptake of metallic mercury by lactoperoxidase in the Lact. -H(2)O(2) system showed a tendency to increase, when the concentration of hydrogen peroxide increased. (4) The uptake of metallic mercury by lactoperoxidase increased with an increase in the lactoperoxidase concentration when the concentration of L-dopa and H(2)O(2) in the Lact. -L-dopa-H(2)O(2) system was constant. This uptake was similar in value to the increase changed by increase in the concentration of hydrogen peroxide.
en-copyright=
kn-copyright=

en-aut-name=AikohHiromi
en-aut-sei=Aikoh
en-aut-mei=Hiromi
kn-aut-name=愛甲博美
kn-aut-sei=愛甲
kn-aut-mei=博美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=Lactoperoxidase
kn-keyword=Lactoperoxidase
en-keyword=Metallic mercury uptake
kn-keyword=Metallic mercury uptake
en-keyword=L-dopa
kn-keyword=L-dopa
END

start-ver=1.4
cd-journal=joma
no-vol=93
cd-vols=
no-issue=7-8
article-no=
start-page=643
end-page=656
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1981
dt-pub=19810830
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Enzymological studies on rheumatoid arthritis. 1. Studies on collagenase and monoamine-oxidase activities in patients with rheumatoid arthritis
kn-title=慢性関節リウマチにおける酵素学的研究 第1編 慢性関節リウマチのコラゲナーゼ活性ならびにモノアミンオキシダーゼ活性について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We assayed the activities of collagenase and monoamine-oxidase (MAO) in the fluid of the patients with rheumatoid arthritis (RA) and examined the relationship between collagenase, MAO activities and the grade of joint inflammation. The mean collagenase value of RA patients was significantly higher than that of osteoarthritis (OA) patients. A significant positive correlation was present between collagenase activity, leukocyte counts, and beta-glucuronidase activity in RA synovial fluid. These indices are considered to be parameters of the grade of joint inflammation. There was no correlation between collagenase activity, erythrocyte sedimentation rate (ESR), gamma-globulin level, C-reactive protein (CRP), rheumatoid factor, acid-phosphatase activity and the stage of RA (grade of joint destruction). The mean MAO value of RA synovial fluid was significantly higher than that of OA synovial fluid. The mean activity of the group of patients whose CRP values were below two positive was significantly higher than that of the group of patients whose CRP values were over two positive. The mean MAO activity in stage 3 or 4 group was significantly higher than that in stage 1 or 2. These findings suggest that collagenase activity is intimately correlated with the grade of local Inflammation in RA and that the MAO activity is closely correlated with the grade of joint fibrosis.
en-copyright=
kn-copyright=

en-aut-name=TodaShunsuke
en-aut-sei=Toda
en-aut-mei=Shunsuke
kn-aut-name=戸田俊介
kn-aut-sei=戸田
kn-aut-mei=俊介
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第三内科
en-keyword=慢性関節リウマチ
kn-keyword=慢性関節リウマチ
en-keyword=コラゲナーゼ活性
kn-keyword=コラゲナーゼ活性
en-keyword=モノアミンオキシダーゼ活性
kn-keyword=モノアミンオキシダーゼ活性
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=20090325
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=マイクロRNAによるCcn2遺伝子を介した軟骨細胞分化の制御機構の解明
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=OogawaraTishihiro
en-aut-sei=Oogawara
en-aut-mei=Tishihiro
kn-aut-name=大河原敏博
kn-aut-sei=大河原
kn-aut-mei=敏博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=95
cd-vols=
no-issue=9-10
article-no=
start-page=1087
end-page=1095
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19831030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic study of the horseradish peroxidase method II. Electron microscopic study
kn-title=西洋ワサビのペルオキシダーゼ法に関する基礎的研究 II. 電子顕微鏡による検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Rat sciatic nerve was observed by electron microscopy using the horseradish peroxidase (HRP) method. The nerve was crushed with a needle and HRP was injected around a sciatic nerve. After 5 hours to 3days, the nerve and spinal cord were dissected and observed under an electron microscope. Five hours after the injection, HRP granules were identified in the axoplasm of myelinated nerve fibers at the injection site. Many HRP granules were distributed in the cytoplasm of motor neurous of the spinal cord 3 days after the injection of HRP. There was no change in cell organella. The neurons in the spinal ganglia also did not show any ultrastructual changes in cell organella 2 to 3 days after the injection of HRP and had many HRP granules in their cytoplasm. These results showed that HRP injected into the crushed end of a sciatic nerve did not induce morphological changes in the motor neurons of the spinal cord and, sensory neurons in spinal ganglia.
en-copyright=
kn-copyright=

en-aut-name=IshimuraHitoshi
en-aut-sei=Ishimura
en-aut-mei=Hitoshi
kn-aut-name=石村均
kn-aut-sei=石村
kn-aut-mei=均
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一解剖学教室
en-keyword=HRP法
kn-keyword=HRP法
en-keyword=坐骨神経
kn-keyword=坐骨神経
en-keyword=脊髄前角細胞
kn-keyword=脊髄前角細胞
en-keyword=脊髄神経節
kn-keyword=脊髄神経節
en-keyword=電子顕微鏡観察
kn-keyword=電子顕微鏡観察
END

start-ver=1.4
cd-journal=joma
no-vol=95
cd-vols=
no-issue=9-10
article-no=
start-page=1077
end-page=1086
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1983
dt-pub=19831030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Basic study of the horseradish peroxidase method I. Light microscopic study
kn-title=西洋ワサビのペルオキシダーゼ法に関する基礎的研究 I. 光学顕微鏡による検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A basic study of the horseradish peroxidase (HRP) method was done using the sciatic nerves of rats. The nerve was crushed with a needle and HRP was injected around the nerve at the site 7-8 cm from the spinal cord. The nerve at the injection site showed an intense positive reaction to HRP 3 to 48 hours after the injection. When the nerve was ligated between the spinal cord and the injection site, HRP accumulated at the distal part of the lesion after 24 hours, and was not detected at the proxismal part of the lesion. When unilateral sciatic nerve was ligated and HRP injected bilateral nerves, motor neurons of the ligated side only did not show positive reaction to HRP. These results showed that HRP was transported by retrograde axonal flow in the nerve. Motor neurons of the cord began to show intense positive reaction 30 hours to 14 days after the injection of HRP around the nerve. The rate of retrograde axonal flow in the nerve was calculated to be 2.6 mm/hr (62.4 mm/day). Neurons in the spinal ganglia were stained intensely 24 hours after the injection of HRP, which suggests more rapid axonal flow in sensory neurons that in motor neurons.
en-copyright=
kn-copyright=

en-aut-name=OkunoKazunori
en-aut-sei=Okuno
en-aut-mei=Kazunori
kn-aut-name=奥野計典
kn-aut-sei=奥野
kn-aut-mei=計典
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一解剖学教室
en-keyword=HRP法
kn-keyword=HRP法
en-keyword=坐骨神経
kn-keyword=坐骨神経
en-keyword=脊髄前角細胞
kn-keyword=脊髄前角細胞
en-keyword=脊髄神経節
kn-keyword=脊髄神経節
END

start-ver=1.4
cd-journal=joma
no-vol=96
cd-vols=
no-issue=1-2
article-no=
start-page=77
end-page=85
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1984
dt-pub=19840228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Quantitative analysis by the oxygen electrode method of superoxide and hydrogen peroxide generated by xanthine oxidase reaction
kn-title=キサンチンオキシダーゼ反応で発生するスーパーオキシドと過酸化水素のオキシグラフによる定量的解析
en-subtitle=
kn-subtitle=
en-abstract=Oxygen consumption and generation of superoxide and hydrogen peroxide by the xanthine oxidase reaction were measured by the polarographic oxygen electrode method. This method requires only a simple apparatus, is very accurate and is easy to perform. The Km for oxygen in the xanthine oxidase reaction measured by this method was 2.1×10(-5)M, which is similar to values measured by other methods. Kinetic analyses of superoxide and hydrogen peroxide generation were made by the addition of superoxide dismutase or cytochrome c before the reaction and catalase after the reaction. More than 13% of the oxygen consumed by the addition of xanthine was found to be converted to superoxide, and 70% was converted to hydrogen peroxide in this system. This method was found to be easy to calibrate the rapid xanthine oxidase reaction and to measure the oxygen consumption and generation of superoxide and hydrogen peroxide.
kn-abstract=酸素電極法によりキサンチンオキシダーゼ反応の酸素に対するKm値,スーパーオキシドの生成量や過酸化水素の生成量などが求められることがわかった.この方法は簡単な装置でよく,また実験も易しく正確に行なえる.酸素電極法で得た私共の酸素に対するKm値は2.1×10(-5)Mであった.この値はstopped flow装置を用いた方法から求められたKm値とほぼ一致しており,この実験方法により簡単にキサンチンオキシダーゼ反応の動態を調べることができることを示している.そしてSODやチトクロームcの反応前添加により,スーパーオキシドの生成量および,過酸化水素の生成量が求められる.この反応系では添加キサンチン量,あるいは酸素消費量の少なくとも13%のスーパーオキシドが生成され,また70%の過酸化水素が生成されていることがわかった.このようにキサンチンオキシダーゼ反応のような速い反応において酸素電極法で調べることは簡単であり,しかもSODやチトクロームc,カタラーゼの組み合わせの工夫により簡単にスーパーオキシドや過酸化水素の生成量が調べられるよい実験系であると考えられる.
en-copyright=
kn-copyright=

en-aut-name=ShigeharaTsuguya
en-aut-sei=Shigehara
en-aut-mei=Tsuguya
kn-aut-name=茂原嗣也
kn-aut-sei=茂原
kn-aut-mei=嗣也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部癌研生化学
en-keyword=キサンチンオキシダーゼ
kn-keyword=キサンチンオキシダーゼ
en-keyword=Kinetics
kn-keyword=Kinetics
en-keyword=スーパーオキシド
kn-keyword=スーパーオキシド
en-keyword=オキシブラフ
kn-keyword=オキシブラフ
en-keyword=過酸化水素
kn-keyword=過酸化水素
END

start-ver=1.4
cd-journal=joma
no-vol=99
cd-vols=
no-issue=5-6
article-no=
start-page=701
end-page=713
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1987
dt-pub=19870630
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Immunohistochemical characterization of lung cancer-associated monoclonal antibodies. II. Immunohistochemical characterization of six lung cancer-associated monoclonal antibodies and their application for sputum cytology.
kn-title=肺癌関連モノクローナル抗体の免疫組織化学的解析　第2編　肺癌関連モノクローナル抗体6種の免疫組織化学的解析と喀痰細胞診への応用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Immunohistochemical reactivities of six lung cancer-associated monoclonal antibodies to the tissue sections of lung cancer, other neoplasms and normal tissues and to the Saccomanno's treated cells were analyzed using an indirect immunoperoxidase technique. The antibodies included LA-4 raised against a lung adenocarcinoma, LSO-4 and -5 against an oat cell lung cancer, LSI-a and -2 against intermediate small cell lung cancers and LE-3 against an epidermoid lung cancer. Six fixation methods were compared, and PFA fixation revealed not to change the antigenisity detected by the antibodies. LSO-4 and -5 antigens were completely dissappered by paraffin-embeded and Saccomanno's treatment. LA-4, LSI-a and -2 were reacted with normal bronchioles and lung cancer tissues. These normal differentiation antigens were expressed on the tissues of lung adenocarcinoma and small cell and epidermoid lung cancers. LE-3 antibody reacted with normal platlets and large intestine tissues, and the LE-3-reacted antigen expressed not only on lung epidermoid cancer but on lung adenocarcinoma. LE-3 did not react with normal lung tissues or Saccomanno's treated normal cells, but reacted the Saccomanno's treated epidermoid lung cancer cells, thus appered to be useful for sputum cytology.
en-copyright=
kn-copyright=

en-aut-name=NakamuraKunihiko
en-aut-sei=Nakamura
en-aut-mei=Kunihiko
kn-aut-name=中村邦彦
kn-aut-sei=中村
kn-aut-mei=邦彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2内科
en-keyword=Lung cancer
kn-keyword=Lung cancer
en-keyword=Monoclonal antibody
kn-keyword=Monoclonal antibody
en-keyword=Immunohistocytechemical study
kn-keyword=Immunohistocytechemical study
en-keyword=Sputum immuno-cytology
kn-keyword=Sputum immuno-cytology
END

start-ver=1.4
cd-journal=joma
no-vol=78
cd-vols=
no-issue=1
article-no=
start-page=179
end-page=188
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1966
dt-pub=19660130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=好中球の顆粒形成と機能に関する形態学的研究　第二編 好中球顆粒の機能に関する形態学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=For the purpose to clarlify the function of neutrophile granules the mature neutrophiles in the circulating blood and bone marrow of rabbit were fed with carbon particles and the relation of phagocytosized carbon particles and neutrophile granules were observed on the sections with or without acid phosphatase reaction.
The pictures demonstrate that the phagocytosized carbon particles fuse with neutrophile grnules and by this fusion the acid phosphatase is strikingly activated in the phagocyjotic vesicles. The similar process was also observed in both phagocytotic vesicles and the granules of the bone marrow.
The picture suggest that neutropnile granules possess many hydrolytic enzymes inside the granules and release them into the phagocytotic vesicles to lyse the phgocytosized foreign bodies.
en-copyright=
kn-copyright=

en-aut-name=KatanoTakashi
en-aut-sei=Katano
en-aut-mei=Takashi
kn-aut-name=片野隆司
kn-aut-sei=片野
kn-aut-mei=隆司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部小児科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=11-12
article-no=
start-page=1159
end-page=1169
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on hematopoietic progenitor cells in acute leukemia and related disease Part 2. Studies on hematopoietic stem cells in myelodysplastic syndrome
kn-title=急性白血病並びに類縁疾患における造血幹細胞動態に関する研究　第2編　Myelodysplastic Syndrome における造血幹細胞の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Peripheral stem cell assay was done to examine the hematopoietic status of myelodysplastic syndrome (MDS). Four patients with refractory anemia with excess of blasts (RAEB) and 6 with RAEB in transformation (RAEBt) were studied. Efficiencies of colony and cluster formation were not different between RAEB and RAEBt, but colony/cluster ratios in RAEBt tended to be lower than in either RAEB or healthy individuals. Patients were classified into 2 groups, Group A and B, according to the colony/cluster formations. In Group A efficiencies of colony/cluster formation were higher than those in healthy individuals, and in Group B they were lower. Bone marrow nucleated cell counts and peripheral white blood cell counts were not different between Groups A and B. Leukemic conversions were recognized in 4 out of 5 cases in Group B and 2 out of 5 cases in Group A, respectively. On the other hand monocytosis developed in 3 out of 5 cases in Group A, but none in Group B. Some of the colonies and clusters were composed of myeloperoxidase (MPO)-negative neutrophils, although a significant increase of MPO-negative neutrophils was not present in original marrow or peripheral blood. Colonies and clusters in patients with leukemic conversions in Group A were composed of cells with blastlike morphology. These findings indicate that the quantitative and qualitative analyses of colonies and clusters are useful not only for the prediction of leukemic conversion but also for analyses of pathophysiological aspects such as ineffective hemopoiesis and monocytosis in MDS.
en-copyright=
kn-copyright=

en-aut-name=NishimuraMasataka
en-aut-sei=Nishimura
en-aut-mei=Masataka
kn-aut-name=西村正隆
kn-aut-sei=西村
kn-aut-mei=正隆
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=骨髄異形成症候群
kn-keyword=骨髄異形成症候群
en-keyword=造血幹細胞
kn-keyword=造血幹細胞
en-keyword=コロニー形成能
kn-keyword=コロニー形成能
en-keyword=コロニー構成細胞
kn-keyword=コロニー構成細胞
END

start-ver=1.4
cd-journal=joma
no-vol=103
cd-vols=
no-issue=4
article-no=
start-page=257
end-page=266
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1991
dt-pub=1991
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effects of SMA-SOD on brain damage induced by complete global brain ischemia in dogs
kn-title=イヌの完全全脳虚血後の脳障害に及ぼすSMA-SOD の効果に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of stylene maleinic acid butyl ester superoxide dismutase (SMA-SOD) on the brain damage induced by ischemia were studied in dogs. Eighteen minutes of cerebral ischemia was produced by clamping the ascending aorta with aorta-atrial and aorta-femoral vein bypass circuit. SMA-SOD(10mg/kg) was administered just after the initiation of recirculation. Dogs were divided into, control group and SMA-SOD group. In each group, cerebral blood flow (CBF) and intracranial pressure (ICP) were measured for 7 hours after ischemia, and neurologic outcome was evaluated up to 7 days after ischemia. Furthermore, extravasation of evans blue dye (EB, 100mg/kg) were observed 30 minutes after ischemia. SMA-SOD increased CBF during the hyperemia, and improved both delayed post-ischemic hypoperfusion (DHP) and neurologic outcomes. Extravasation of EB were recognized in the control group, but not in the SMA-SOD group.
In conclusion, vasogenic edema might play a role in the elevation of ICP besides the hyperemia, and SMA-SOD improved neurologic outcome by prevention of edema, and improvement of DHP. Furthermore, free radicals might play a role in the appearance of ischemic brain damage.
en-copyright=
kn-copyright=

en-aut-name=TakedaYoshimasa
en-aut-sei=Takeda
en-aut-mei=Yoshimasa
kn-aut-name=武田吉正
kn-aut-sei=武田
kn-aut-mei=吉正
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部麻酔・蘇生学教室
en-keyword=SMA-SOD
kn-keyword=SMA-SOD
en-keyword=神経学的予後
kn-keyword=神経学的予後
en-keyword=血流脳関門
kn-keyword=血流脳関門
en-keyword=遅発性脳血流減少
kn-keyword=遅発性脳血流減少
en-keyword=イヌ
kn-keyword=イヌ
END

start-ver=1.4
cd-journal=joma
no-vol=98
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=7
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2009
dt-pub=200902
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Expression, Purification and Properties of Alanine Racemase from Thermus thermophillus HB8
kn-title=高度好熱性細菌 Thermus thermophilus HB8 由来アラニンラセマーゼの大腸菌での発現，精製及び諸性質の検討
en-subtitle=
kn-subtitle=
en-abstract=高度好熱性細菌 Thermus thermophilus HB8 由来アラニンラセマーゼ遺伝子を大腸菌中にクローニングし、発現させた後に、精製及び性質検討を行った。alr遺伝子は1080bpからなり360アミノ酸残基 HB8をコードしていたので、本酵素は38,596Daの分子量であると予想された。alr遺伝子の [ G + C ] 含量は、72%であり、Tm値は98.8℃であった。T.thermophilus HB8由来アラニンセマーゼを中等度好熱性細菌 Geobacillus stearothermophilus 及び赤痢菌 Shigella sonnei 由来アラニンラセマーゼと一次配列の比較をしたところ、G.stearothermophilus 由来のものと33%、赤痢菌由来の酵素を28%の相同性を示した。T.thermophilus HB8 由来アラニンラセマーゼを、70℃で10分間の熱処理後、DEAE-トーヨーパール陰イオン交換カラム等により精製した。精製酵素の最適温度は、d-アラニンからl-アラニンへの反応で55℃、l-アラニンからd-アラニンへの反応では60℃であり、最適pHは、9.0?10.0であった。また、70℃で30分インキュベーションを行った後にも、活性の低下は見受けられず耐熱性を示した。更に、本酵素は分子量38,000モノマー酵素であると推定され、その反応機構に興味が持たれる。
kn-abstract=An alanine racemase (EC 5.1.1.1) from an extreme thermophilic bacterium Thermus thermophilus HB8, was purified and characterized, and its gene was cloned. The cloned alanine racemase gene (alr) was expressed in Escherichia coli JM 109. The alr gene is composed of a 1080 bp and encoded a 360 amino
acid, and was predicted to have a molecular weight of 38,596. The enzyme was purified by heat shock at 70°C for 10min and DEAE Toyopearl 650M column chromatography. The purified enzyme had an optimum pH9.0?10.0 and an optimum temperature of 55°C?60°C. Enzyme activity was retained 100% after incubation of the enzyme at 70°C for 10min. Alanine racemase from Thermus thermophilus HB8 is a monomeric enzyme with a molecular mass of 39 kDa.
en-copyright=
kn-copyright=

en-aut-name=YanagitaniMasahiko
en-aut-sei=Yanagitani
en-aut-mei=Masahiko
kn-aut-name=柳谷昌彦
kn-aut-sei=柳谷
kn-aut-mei=昌彦
aut-affil-num=1
ORCID=

en-aut-name=UemaeSatoshi
en-aut-sei=Uemae
en-aut-mei=Satoshi
kn-aut-name=上前智
kn-aut-sei=上前
kn-aut-mei=智
aut-affil-num=2
ORCID=

en-aut-name=ShiragaTomoyuki
en-aut-sei=Shiraga
en-aut-mei=Tomoyuki
kn-aut-name=白神智行
kn-aut-sei=白神
kn-aut-mei=智行
aut-affil-num=3
ORCID=

en-aut-name=TamuraTakashi
en-aut-sei=Tamura
en-aut-mei=Takashi
kn-aut-name=田村隆
kn-aut-sei=田村
kn-aut-mei=隆
aut-affil-num=4
ORCID=

en-aut-name=InagakiKenji
en-aut-sei=Inagaki
en-aut-mei=Kenji
kn-aut-name=稲垣賢二
kn-aut-sei=稲垣
kn-aut-mei=賢二
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学

affil-num=3
en-affil=
kn-affil=岡山大学

affil-num=4
en-affil=
kn-affil=岡山大学

affil-num=5
en-affil=
kn-affil=岡山大学
en-keyword=alanine racemase
kn-keyword=alanine racemase
en-keyword=pyridoxal 5’-phosphate
kn-keyword=pyridoxal 5’-phosphate
en-keyword=thermostable enzyme
kn-keyword=thermostable enzyme
en-keyword=Thermus thermophilus HB8
kn-keyword=Thermus thermophilus HB8
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=暑熱ストレスがヒトおよび実験動物の生体に及ぼす影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=AsanumaShinji
en-aut-sei=Asanuma
en-aut-mei=Shinji
kn-aut-name=浅沼信治
kn-aut-sei=浅沼
kn-aut-mei=信治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=単球におけるＬＰＳ誘導性の新規ＴＮＦ-α転写制御因子に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MurataHiromi
en-aut-sei=Murata
en-aut-mei=Hiromi
kn-aut-name=村田裕美
kn-aut-sei=村田
kn-aut-mei=裕美
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=11-12
article-no=
start-page=1093
end-page=1105
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of guanidino compounds on monoamine oxidase and catechol-O-methyltransferase activity
kn-title=モノアミン代謝酵素活性に及ぼすグアニジノ化合物の影響に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the central nervous system (CNS)of mammals, monoamine oxidase (EC 1.4.3.4)(MAO), which have been divided into two functional forms (MAO-A and MAO-B), and catechol-O-methyltransferase (EC 2.1.1.6)(COMT) act as catabolic enzymes of catecholamines and serotonin regulating their concentrations. In this study, the effects of guanidino compounds (5mM) on MAO-A, MAO-B and COMT were examined to invastigate the role of guanidino compounds in CNS function. MAO-A activity was decreased by α-guanidinoglutaric acid (GGA) and guanidinoethanesulfonic acid, and increased by arginine (Arg) and N-acetylarginine at a low substrate concentration (4.33μM). MAO-B activity was decreased by creatinine (CRN), δ-guanidinovaleric acid (GVA) and methylguanidine (MGua) at a high substrate concentration (3.125mM), and decreased by CRN, GVA, MGua, Arg, guanidine, 2-guanidinoethanol, β-guanidinopropionic acid, guanidinosuccinic acid and homoarginine at a low substrate concentration (62.5μM). GVA, CRN and MGua acted as competitive inhibitors on MAO-B and their calculated Ki values were 9.47mM, 14.5mM and 29.4mM, respectively. Although the guanidino compounds tested had no effect on COMT activity at a high substrate concentration (600μM), GSA and GVA inhibited COMT activity at a low substrate concentration (75μM). These results suggest that some guanidino compounds influence catabolic enzymes of indoleamine and catecholamines to control CNS function.
en-copyright=
kn-copyright=

en-aut-name=HukuyamaKatsuhisa
en-aut-sei=Hukuyama
en-aut-mei=Katsuhisa
kn-aut-name=福山勝久
kn-aut-sei=福山
kn-aut-mei=勝久
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属分子細胞医学研究施設神経情報学部門
en-keyword=guanidino compounds
kn-keyword=guanidino compounds
en-keyword=monoamine oxidase A
kn-keyword=monoamine oxidase A
en-keyword=monoamine oxidase B
kn-keyword=monoamine oxidase B
en-keyword=chatechol-O-methyltransferase
kn-keyword=chatechol-O-methyltransferase
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=7-8
article-no=
start-page=797
end-page=807
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199208
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on IgG subclass antibodies in asthmatics with late asthmatic responses Part 1. Serum antigen-specific IgG subclass antibodies in asthmatics with late asthmatic response
kn-title=遅発型気道反応におけるIgG サブクラス抗体に関する研究　第1編　血清中抗原特異的 IgG サブクラス抗体と遅発型気道反応の関連について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The immediate asthmatic response is mainly induced by IgE-dependent mechanisms. However, the late asthmatic response (LAR) is induced by inhalation of antigens without the participation of antigen-specific IgE antibodies in some asthmatics, especially in intractable asthma induced by Candida antigen. To elucidate the relationship between antibodies and those bronchial responses, the antigen-specific IgG subclass antibodies in sera from asthmatics were measureed and compared with IgE antibody. The avidin-biotin ELISA (enzyme-linked immunosorbent assay) method was established for the measurement of specific IgG and IgG subclass antibodies to mite or Candida antigen. Serum levels of IgG and IgG1 antibodies to mite and Candida antigen in bronchial asthmatics were significantly higher than those in healthy subjects (p<0.01). Bronchial asthmatics who were tested with inhalation of house dust or Candida antigen were divided into group A (higher levels of serum IgG1 antibody) and group B (lower levels of serum IgG1 antibody). The percentage of LAR including DAR after inhalation of house dust antigen in group A were significantly higher than those in group B (p<0.01). The percentages of LAR and LAR including DAR after inhalation of Candida antigen in group A were significantly higherSerum levels of house du than those in group B(p<0.01). Serum levels of antigen-specific IgG and IgG1 antibodies in asthmatics with LAR after inhalation of house dust or Candida antigen were significantly higher than those in asthmatics with IAR or non-responders (p<0.01). The serum level of specific IgE antibody to these antigens in asthmatics with LAR after inhalation of house dust or Candida antigen was slightly lower than that in the asthmatics without LAR, though the difference was not significant. These findings suggest that high serum levels of specific IgG and IgG1 antibodies to adequate antigens play a role in inducing an attack in asthmatics with LAR.
en-copyright=
kn-copyright=

en-aut-name=OgurusuKazuro
en-aut-sei=Ogurusu
en-aut-mei=Kazuro
kn-aut-name=小栗栖和郎
kn-aut-sei=小栗栖
kn-aut-mei=和郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=遅発型気道反応
kn-keyword=遅発型気道反応
en-keyword=IｇG サブクラス抗体
kn-keyword=IｇG サブクラス抗体
en-keyword=IgE 抗体
kn-keyword=IgE 抗体
en-keyword=抗原吸入誘発試験
kn-keyword=抗原吸入誘発試験
en-keyword=難治性喘息
kn-keyword=難治性喘息
END

start-ver=1.4
cd-journal=joma
no-vol=105
cd-vols=
no-issue=5-6
article-no=
start-page=601
end-page=610
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1993
dt-pub=1993
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies of human bone marrow stromal cells in the aged Part 2. Effects of anticancer agents on the growing dynamics of bone marrow stromal cells in the aged and their ability to sustain normal hemopoiesis
kn-title=骨髄間質細胞の老化に関する研究　第2編　高齢者骨髄間質細胞の増殖動態並びに造血支持能に及ぼす抗白血病剤の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Prolonged marrow suppresson after chemotherapy with anticancer agents is often seen, especially in elderly patients. The effects of anticancer agents on the growing dynamics of bone marrow stromal cells (BMSC) in the aged and their ability to sustain the growth of normal hemopoietic progenitor cells (suppportability) were examined to investigate the cause of prolonged marrow suppression. Daunorubicin (DNR) suppressed either the proliferation of BMSC or the ability to sustain hemopoiesis as a function of its concentration. Cytosine arabinoside (ara-C) did not suppress growing dynamics or supportability. Methotrexate (MTX) suppressed supportability at higher concentrations, even though it barely suppressed growing dynamics. These results were similar to those from an investigation in younger volunteers. It should be noted that DNR suppresses BMSC function at standard clinical concentrations. However, antimetabolites, especially ara-C are considered comparatively safe drugs for elderly patients.
en-copyright=
kn-copyright=

en-aut-name=DeguchiSeigo
en-aut-sei=Deguchi
en-aut-mei=Seigo
kn-aut-name=出口静吾
kn-aut-sei=出口
kn-aut-mei=静吾
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Human marrow stromal cells
kn-keyword=Human marrow stromal cells
en-keyword=Aging
kn-keyword=Aging
en-keyword=Chemotherapy
kn-keyword=Chemotherapy
en-keyword=Growing dynamics
kn-keyword=Growing dynamics
en-keyword=Ability to sustain hemopoiesis
kn-keyword=Ability to sustain hemopoiesis
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=3-4
article-no=
start-page=261
end-page=273
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=1994
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on human bone marrow stromal cells Part 1. Effects of antileukemic agents on human bone marrow stromal cells
kn-title=ヒト骨髄間質細胞に関する研究　第1編 ヒト骨髄間質細胞の増殖動態並びに造血支持能に及ぼす抗白血病剤の影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of antileukemic agents on the growth of human bone marrow stromal cells (HBMSC) and its ability to sustain the growth of normal hematopoietic progenitors were studied by using a modified Dexter's culture system. Antileukemic agents used were daunor-ubicin (DNR), doxorubicin (DXR), mitoxantron (MIT), aclarubicin (ACR), vincristine (VCR), cyclophosphamide (CPM), cytosine arabinoside (ara-C) and methotrexate (MTX). In this experiment, HBMSC were exposed to each concentration of DNR, DXR, MIT, ACR, VCR and CPM for 3 hours, and to ara-C and MTX for 7 days. DNR, DXR, MIT and ACR suppressed the growth of HBMSC at the concentration of ≧10(-6)M, and also suppressed its ability to sustain the growth of normal hematopoietic progenitors at the concentration of ≧10(-7)M. VCR suppressed both the growth of HBMSC and its ability to sustain the growth of normal hematopoietic progenitors at the concentration of and also suppressed its ability to suatain the growth of norwth hematopoietic progenitors at the concentration of ≧10(-7)M. CPM suppressed the growth of HBMSC at the concentration of >10(-4)M. However, its ability to sustain the growth of normal hematopoietic progenitors was not suppressed. Ara-C and MTX did not suppress the growth of HBMSC at the concentration of 10(-8)M to 10(-3)M. The ability of HBMSC to sustain the growth of normal hematopoietic progenitors was not suppressed by Ara-C. On the other hand, it was suppressed by MTX of >10(-4)M. These findings, which clarified the effects of the antileukemic agents on the functions of HBMSC, provide some information not only on the optimal combination of antileukemic agents and premedication of bone marrow transplantation, but also on drug-induced hematotoxicity.
en-copyright=
kn-copyright=

en-aut-name=MatsuzakiToshiaki
en-aut-sei=Matsuzaki
en-aut-mei=Toshiaki
kn-aut-name=松�ｱ敏朗
kn-aut-sei=松�ｱ
kn-aut-mei=敏朗
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=Human bone marrow stromal cells
kn-keyword=Human bone marrow stromal cells
en-keyword=Long-term bone marrow culture
kn-keyword=Long-term bone marrow culture
en-keyword=Chemotherapy
kn-keyword=Chemotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=106
cd-vols=
no-issue=7-8
article-no=
start-page=837
end-page=846
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=199408
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Sustaining capacity of hemopoiesis by human stromal cells in bone marrow
kn-title=ヒト骨髄間質細胞の造血支持能に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A bone marrow coculturing system developed by M. Y.Gordon was modified for easier evaluation of the function of bone marrow stromal cells. In the method agar was not used, and cells were dried and stained directly on a 35-mm petri dish after culture. The sustaining capacity of hemopoiesis by human stromal cells in bone marrow obtained by this method was compared between eight young and five eldery healthy volunteers. Hemopoietic progenitor cells were obtained from young volunteers and cultures were prepared for seven days. These appeared 86±28 colonies from 10(5) non-adherent bone marrow cells on the sheet of stromal cells from the young volunteers and 89±27 colonies from the eldery. The colonies were classified into two types according to cytochemical appearance through peroxidase staining, but all of them proved to be composed of myeloid cells by enzyme-labeled antibody staining. Colonies were identified easily and accurately by the newly modified coculturing method. No difference in sustaining capacity of hemopoiesis by human stromal cells in bone marrow was found between the young and the eldery using this system.
en-copyright=
kn-copyright=

en-aut-name=UekiKoubun
en-aut-sei=Ueki
en-aut-mei=Koubun
kn-aut-name=植木康文
kn-aut-sei=植木
kn-aut-mei=康文
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=human marrow stromal cell
kn-keyword=human marrow stromal cell
en-keyword=ability to sustain hemopoiesis
kn-keyword=ability to sustain hemopoiesis
en-keyword=IL-6 production
kn-keyword=IL-6 production
en-keyword=aging
kn-keyword=aging
END

start-ver=1.4
cd-journal=joma
no-vol=119
cd-vols=
no-issue=3
article-no=
start-page=235
end-page=239
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=20080104
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Quinone formation as a common neurotoxic factor in dopaminergic neurotoxicity induced by an excess amount of cytosolic dopamine
kn-title=小胞外過剰ドパミンによるドパミン神経障害における共通因子としてのキノン体生成
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MiyazakiIkuko
en-aut-sei=Miyazaki
en-aut-mei=Ikuko
kn-aut-name=宮崎育子
kn-aut-sei=宮崎
kn-aut-mei=育子
aut-affil-num=1
ORCID=

en-aut-name=AsanumaMasato
en-aut-sei=Asanuma
en-aut-mei=Masato
kn-aut-name=浅沼幹人
kn-aut-sei=浅沼
kn-aut-mei=幹人
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=Francisco J.Diaz-Corrales
kn-aut-sei=Francisco J.
kn-aut-mei=Diaz-Corrales
aut-affil-num=3
ORCID=

en-aut-name=MiyoshiKo
en-aut-sei=Miyoshi
en-aut-mei=Ko
kn-aut-name=三好耕
kn-aut-sei=三好
kn-aut-mei=耕
aut-affil-num=4
ORCID=

en-aut-name=OgawaNorio
en-aut-sei=Ogawa
en-aut-mei=Norio
kn-aut-name=小川紀雄
kn-aut-sei=小川
kn-aut-mei=紀雄
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 神経情報学
en-keyword=ドパミンキノン
kn-keyword=ドパミンキノン
en-keyword=パーキンソン病
kn-keyword=パーキンソン病
en-keyword=メタンフェタミン
kn-keyword=メタンフェタミン
en-keyword=キノン還元酵素
kn-keyword=キノン還元酵素
en-keyword=チロシナーゼ
kn-keyword=チロシナーゼ
END

start-ver=1.4
cd-journal=joma
no-vol=119
cd-vols=
no-issue=1
article-no=
start-page=83
end-page=85
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070501
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug interaction (9. effect of smoking)
kn-title=薬物相互作用 (9―喫煙と薬の相互作用)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SagaraHidenori
en-aut-sei=Sagara
en-aut-mei=Hidenori
kn-aut-name=相良英憲
kn-aut-sei=相良
kn-aut-mei=英憲
aut-affil-num=1
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=北村佳久
kn-aut-sei=北村
kn-aut-mei=佳久
aut-affil-num=2
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=3
ORCID=

en-aut-name=GomitaYutaka
en-aut-sei=Gomita
en-aut-mei=Yutaka
kn-aut-name=五味田裕
kn-aut-sei=五味田
kn-aut-mei=裕
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　薬剤部

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科 医薬管理学

affil-num=3
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　薬剤部

affil-num=4
en-affil=
kn-affil=岡山大学医学部・歯学部附属病院　薬剤部
END

start-ver=1.4
cd-journal=joma
no-vol=119
cd-vols=
no-issue=1
article-no=
start-page=41
end-page=47
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20070501
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=An animal model of status epilepticus induced by massed electrical stimulations to the deep prepiriform cortex
kn-title=深部前梨状葉皮質の間欠的電気刺激によるてんかん発作重積モデル
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hippocampal damage induced by status epilepticus (SE) has been suggested as the developmental pathway of temporal lobe epilepsy. We developed an experimental model of SE induced by massed electrical stimulations into the deep prepiriform cortex. Stimulations under aminophylline pretreatment more effectively induced SE than those in the absence of aminophylline. Most SE episodes included secondary generalized seizures. Cresyl violet staining indicated neuronal degeneration in CA1 and CA3, 1-2 weeks after the SE. Mild neuronal loss was observed 8 weeks after the SE, although there were no obvious histological changes in the hilus. Immunoreactivity for GluR1, a subunit of the AMPA receptors, was reduced in CA3 and the hilus starting 1 week after SE, indicating a discrepancy between the distributions of neuronal damage and the GluR1 decrement. The present model serves as a useful model of SE. Further improvement of this method will make it an effective tool for understanding the developmental process of temporal lobe epilepsy.
en-copyright=
kn-copyright=

en-aut-name=KoyamaFumihiko
en-aut-sei=Koyama
en-aut-mei=Fumihiko
kn-aut-name=小山文彦
kn-aut-sei=小山
kn-aut-mei=文彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大岡山大学大学院医歯薬学総合研究科 精神神経病態学
en-keyword=けいれん発作重積(status epilepticus)
kn-keyword=けいれん発作重積(status epilepticus)
en-keyword=深部前梨状葉皮質(deep prepiriform cortex)
kn-keyword=深部前梨状葉皮質(deep prepiriform cortex)
en-keyword=反復電気刺激(massed electrical stimulations)
kn-keyword=反復電気刺激(massed electrical stimulations)
en-keyword=AMPA型受容体(AMPA receptors)
kn-keyword=AMPA型受容体(AMPA receptors)
en-keyword=ラット(rat)
kn-keyword=ラット(rat)
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20071231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=HL-60細胞におけるA23187誘導アポトーシスのメカニズム：NADPHオキシダーゼではなくミトコンドリア膜透過性遷移への依存
kn-title=Mechanism of A23187-Induced Apoptosis in HL-60 Cells: Dependency on Mitochondrial Permeability Transition but Not on NADPH Oxidase
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KajitaniNoriko
en-aut-sei=Kajitani
en-aut-mei=Noriko
kn-aut-name=梶谷典子
kn-aut-sei=梶谷
kn-aut-mei=典子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=79
end-page=85
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19950131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Comparative studies of proliferating cell nuclear antigen and bromodeoxyuridine staining pattern in rat regenerating liver cells
kn-title=ラット再生肝組織におけるProliferating Cell Nuclear AntigenとBromodeoxyuridineの染色性についての比較研究 ―固定条件の影響について―
en-subtitle=
kn-subtitle=
en-abstract=Immunohistochemical staining pattern of proliferating cell nuclear antigen (PCNA) was examined in rat regenarating liver specimens fixed under the various conditions (10% buffered formalin for 6 hr, 1% paraformaldehyde for 6 hr, 100% methanol for 4 hr, 70% ethanol for 6 hr, 100% acetone for 2 hr and Carnoy solution for 4 hr). Most distinct granular staining pattern of PCNA was observed in fixation with 100% methanol or 70% ethanol. Specimens fixed with 10% buffered formalin or 1% paraformaldehyde showed both distinct granular and slight diffuse pattern of PCNA staining. Specimens fixed with 100% acetone showed only slight diffuse staining. Specimens fixed with Carnoy solution showed little staining. Number of PCNA positive cells in the specimens fixed with 100% methanol or 70% ethanol on 24 hours after hepatectomy coincided closely with those of BrdU positive cells, which is known to be a representative marker of cell proliferation. In contrast, dissociative result was obtained in specimens fixed with 10% buffered formalin, 1% paraformaldehyde, 100% acetone or Carnoy solution when numbers of PCNA positive cells were compared with those of BrdU. These findings suggest that tissue specimens fixed with 100% methanol or 70% ethanol is useful for evaluating the extent of cell proliferation.
kn-abstract=種々の条件下（10％緩衝ホルマリン・6時間、1％パラホルムアルデヒド・6時間、100％メタノール・4時間、70％エタノール・6時間、100％アセトン・2時間、カルノア液・4時間）で固定したラット再生肝組織に免疫組織染色を施し、Proliferating cell nuclear antigen （PCNA）の核内染色パターンについての検討を行った。その結果、100％メタノール及び70％エタノールで固定した場合には、明瞭な顆粒状の染色像が得られた。10％緩衝ホルマリン及び1％パラホルムアルデヒドの場合には、明瞭な顆粒状並びに弱いびまん性の染色像が得られた。S期に対する代表的なマーカーとして知られるBromodeoxyuridine （BrdU）の染色像との比較のもと、再生肝組織中のPCNA陽性細胞の数とBrdU陽性細胞の数を再生ピーク時の術後1日目で検討したところ、100％メタノール及び70％エタノールで固定した際の陽性細胞数が、最もBrdUの所見と一致した。しかし、10％緩衝ホルマリン、1％パラホルムアルデヒド、100％アセトン、カルノア液で固定した場合には、BrdUの所見と著しい解離が見られた。これらの知見は、PCNAを指標に細胞増殖を評価する上で、100％メタノール、70％エタノールでの固定が有用であることを示唆する。
en-copyright=
kn-copyright=

en-aut-name=SakiyamaJunko
en-aut-sei=Sakiyama
en-aut-mei=Junko
kn-aut-name=�ｱ山順子
kn-aut-sei=�ｱ山
kn-aut-mei=順子
aut-affil-num=1
ORCID=

en-aut-name=MoriShuji
en-aut-sei=Mori
en-aut-mei=Shuji
kn-aut-name=森秀治
kn-aut-sei=森
kn-aut-mei=秀治
aut-affil-num=2
ORCID=

en-aut-name=IchimuraMituko
en-aut-sei=Ichimura
en-aut-mei=Mituko
kn-aut-name=一村光子
kn-aut-sei=一村
kn-aut-mei=光子
aut-affil-num=3
ORCID=

en-aut-name=TohgeHiroko
en-aut-sei=Tohge
en-aut-mei=Hiroko
kn-aut-name=唐下博子
kn-aut-sei=唐下
kn-aut-mei=博子
aut-affil-num=4
ORCID=

en-aut-name=OkamotoMotoi
en-aut-sei=Okamoto
en-aut-mei=Motoi
kn-aut-name=岡本基
kn-aut-sei=岡本
kn-aut-mei=基
aut-affil-num=5
ORCID=

en-aut-name=EndoHiroshi
en-aut-sei=Endo
en-aut-mei=Hiroshi
kn-aut-name=遠藤浩
kn-aut-sei=遠藤
kn-aut-mei=浩
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=2
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=3
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=4
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=5
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=6
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科
en-keyword=PCNA
kn-keyword=PCNA
en-keyword=BrdU
kn-keyword=BrdU
en-keyword=免疫組織染色 (immunohistochemical staining)
kn-keyword=免疫組織染色 (immunohistochemical staining)
en-keyword=再生肝 (regenerating liver)
kn-keyword=再生肝 (regenerating liver)
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=
article-no=
start-page=65
end-page=70
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1995
dt-pub=19950131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Antibody to Propionibacterium acnes (P.acnes) in guinea pigs with pulmonary granulomatosis
kn-title=Propionibacterium acnes感作肺肉芽腫モルモットの特異抗体の測定
en-subtitle=
kn-subtitle=
en-abstract=In guinia pig models of P.ances induced pulmonary granulomatosis, anti-P.acnes antibody activity in bronchoalveolar lavage fluid peaked at 1 week after the endotracheally injection and decreased progressively, attaining control animal value by 4 weeks. The change of lymphocyte counts paralleled the change of anti-P.acnes antibody activity levels in bronchoalveolar fluids. Furthermore, the degree of granuloma formation in the lung paralleled the rise of anti-P.acnes antibody activity level. This data suggests that the anti-P.acnes antibody play a central role in the induction of lymphocyte alveolitis in experimental pulmonary granulomatosis.
kn-abstract=P.acnesを皮内前感作した後、P.acnes菌体壁成分をimcomplete Freund's adjuvantと共に気管内に投与して作製した実験的肺肉芽腫症モルモットにおける抗P.acnes抗体について検討した。気管支肺胞洗浄液中抗P.acnes抗体価は気管内投与後1週目ピークを示し2週目までは上昇が認められ、4週目では気管内投与前の値に復した。この経過は肺胞内リンパ球数の変動と軌を一にしており、抗体価とリンパ球数の間には正の強い相関が認められた。血清中の抗P.acnes抗体価は1週目に低下が認められ、2週以後に徐々に回復して4週以後は元に戻った。P.acnesの気管内投与により血清中の抗体は肺へと移行し、リンパ球浸潤による胞隔炎、更には類上皮細胞肉芽腫の形成にP.acnesの関与を示すものであった。
en-copyright=
kn-copyright=

en-aut-name=NakataYasunari
en-aut-sei=Nakata
en-aut-mei=Yasunari
kn-aut-name=中田安成
kn-aut-sei=中田
kn-aut-mei=安成
aut-affil-num=1
ORCID=

en-aut-name=MoriYoshihiro
en-aut-sei=Mori
en-aut-mei=Yoshihiro
kn-aut-name=森由弘
kn-aut-sei=森
kn-aut-mei=由弘
aut-affil-num=2
ORCID=

en-aut-name=EjiriTohgo
en-aut-sei=Ejiri
en-aut-mei=Tohgo
kn-aut-name=江尻東伍
kn-aut-sei=江尻
kn-aut-mei=東伍
aut-affil-num=3
ORCID=

en-aut-name=KataokaMikio
en-aut-sei=Kataoka
en-aut-mei=Mikio
kn-aut-name=片岡幹男
kn-aut-sei=片岡
kn-aut-mei=幹男
aut-affil-num=4
ORCID=

en-aut-name=HiramatsuJun-ichi
en-aut-sei=Hiramatsu
en-aut-mei=Jun-ichi
kn-aut-name=平松順一
kn-aut-sei=平松
kn-aut-mei=順一
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=2
en-affil=
kn-affil=高松病院

affil-num=3
en-affil=
kn-affil=市立吉備病院

affil-num=4
en-affil=
kn-affil=岡山大学医学部第二内科

affil-num=5
en-affil=
kn-affil=岡山大学医学部第二内科
en-keyword=サルコイドーシス (sarcoidosis)
kn-keyword=サルコイドーシス (sarcoidosis)
en-keyword=プロピオニバクテリウム (propionibacteium acnes)
kn-keyword=プロピオニバクテリウム (propionibacteium acnes)
en-keyword=肺肉芽腫症 (pulmonary granulomatosis)
kn-keyword=肺肉芽腫症 (pulmonary granulomatosis)
en-keyword=動物実験モデル (experimental model)
kn-keyword=動物実験モデル (experimental model)
en-keyword=気管支肺胞洗浄液 (bronchoalveolar lavage)
kn-keyword=気管支肺胞洗浄液 (bronchoalveolar lavage)
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=53
end-page=55
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=19940131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Clearance study of polyethylene glycol-modified cholesterol esterase.
kn-title=ポリエチレングリコール修飾によるコレステロールエステル分解酵素の体内挙動変化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The clearance of polyethylene glycol-modified cholesterol esterase was investigated spectrophotometrically, as compared with native one. PEG-modification provided the significant elongation in clearance time of cholesterol esterase after intravenous injection in mouse. This method was shown to be effective for creating new biomaterials.
en-copyright=
kn-copyright=

en-aut-name=MoriShuji
en-aut-sei=Mori
en-aut-mei=Shuji
kn-aut-name=森秀治
kn-aut-sei=森
kn-aut-mei=秀治
aut-affil-num=1
ORCID=

en-aut-name=NakataYasunari
en-aut-sei=Nakata
en-aut-mei=Yasunari
kn-aut-name=中田安成
kn-aut-sei=中田
kn-aut-mei=安成
aut-affil-num=2
ORCID=

en-aut-name=EndoHiroshi
en-aut-sei=Endo
en-aut-mei=Hiroshi
kn-aut-name=遠藤浩
kn-aut-sei=遠藤
kn-aut-mei=浩
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=2
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=3
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科
en-keyword=cholesterol esterase
kn-keyword=cholesterol esterase
en-keyword=polyethylene glycol modification
kn-keyword=polyethylene glycol modification
en-keyword=in vivo clearance
kn-keyword=in vivo clearance
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=47
end-page=51
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1994
dt-pub=19940131
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=IgG Heavy-Chain Subclass Typing of Human Serum M-Protein -Optimal condition for the separation and the detection with high resolution of agarose gel isoelectrofocusing-
kn-title=ヒト血清M蛋白のIgGH鎖サブクラスの型判定について　−高分解能アガロースゲル等電点電気泳動法の分離と検出のための条件設定−
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=IgG Heavy-Chain subclass typing of human serum M-protein were isoelectrofocussed (IEF) in agarose gel, and then the bands of IgG were detected with peroxidase-conjugated anti-human IgG1-4 monoclonal antibodies on the same isoelectrofocussed agarose gel plate. This IEF enzyme immunodetection patterns were composed of four to eight discrete bands (The range of pI was 6.0 to 9.0). These bands were dependent on immunofixationbands. It was very specific and clear to detect the subclass of IgG Type M-protein in human serum using this method.
en-copyright=
kn-copyright=

en-aut-name=IchimuraMitsuko
en-aut-sei=Ichimura
en-aut-mei=Mitsuko
kn-aut-name=一村光子
kn-aut-sei=一村
kn-aut-mei=光子
aut-affil-num=1
ORCID=

en-aut-name=TohgeHiroko
en-aut-sei=Tohge
en-aut-mei=Hiroko
kn-aut-name=唐下博子
kn-aut-sei=唐下
kn-aut-mei=博子
aut-affil-num=2
ORCID=

en-aut-name=SakiyamaJunko
en-aut-sei=Sakiyama
en-aut-mei=Junko
kn-aut-name=崎山順子
kn-aut-sei=崎山
kn-aut-mei=順子
aut-affil-num=3
ORCID=

en-aut-name=NakataYasunari
en-aut-sei=Nakata
en-aut-mei=Yasunari
kn-aut-name=中田安成
kn-aut-sei=中田
kn-aut-mei=安成
aut-affil-num=4
ORCID=

en-aut-name=EndoHiroshi
en-aut-sei=Endo
en-aut-mei=Hiroshi
kn-aut-name=遠藤浩
kn-aut-sei=遠藤
kn-aut-mei=浩
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=2
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=3
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=4
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科

affil-num=5
en-affil=
kn-affil=岡山大学医療技術短期大学部衛生技術学科
en-keyword=IgG Subclass
kn-keyword=IgG Subclass
en-keyword=M-Protein
kn-keyword=M-Protein
en-keyword=Isoelectrofocusing
kn-keyword=Isoelectrofocusing
en-keyword=Monoclonal Antibodies
kn-keyword=Monoclonal Antibodies
END