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cd-journal=joma
no-vol=13
cd-vols=
no-issue=
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start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Newsletter from Course for Prospective Museum Workers, Faculty of Letters, Okayama University
kn-title=学芸員課程 Newsletter 第13号
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=光本順
kn-aut-sei=光本
kn-aut-mei=順
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=加治木智也
kn-aut-sei=加治木
kn-aut-mei=智也
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=英大智
kn-aut-sei=英
kn-aut-mei=大智
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=文学部

affil-num=2
en-affil=
kn-affil=今治市教育委員会文化振興課文化財係

affil-num=3
en-affil=
kn-affil=農林水産省
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=
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dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Newsletter from Course for Prospective Museum Workers, Faculty of Letters, Okayama University
kn-title=学芸員課程 Newsletter 第12号
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
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ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=鈴木恒志
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kn-aut-mei=恒志
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=木下莉沙
kn-aut-sei=木下
kn-aut-mei=莉沙
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=黒木恵那
kn-aut-sei=黒木
kn-aut-mei=恵那
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=多田絢音
kn-aut-sei=多田
kn-aut-mei=絢音
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=小野田澪
kn-aut-sei=小野田
kn-aut-mei=澪
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=文学部

affil-num=2
en-affil=
kn-affil=文学部 哲学芸術学専修コース

affil-num=3
en-affil=
kn-affil=文学部 地理学・社会学・文化人類学・社会文化学分野

affil-num=4
en-affil=
kn-affil=文学部 歴史学・考古学分野

affil-num=5
en-affil=
kn-affil=文学部 芸術学・美術史分野

affil-num=6
en-affil=
kn-affil=文学部 歴史学・考古学分野
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=
article-no=
start-page=7
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191225
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=幼児の異文化適応過程における意識の発達に関する一考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　幼児の異文化適応のプロセスに焦点を当てた心理臨床学的研究はほとんど見当たらないが，グローバル社会における幼児の異文化適応における心理支援を考える上では，検討が必要である。本研究では事例研究法を用い， １人の幼児の異文化適応のプロセスを意識の発達という視点から検討を行った。その結果，集団の意識と個の意識という対極的な意識を統合し，また国や民族といった表層の差異を越えた，人間としての普遍性の次元でつながりを確立することで，幼児の異文化適応が深化していると考えられた。また，その異文化適応の心理支援の際に配慮すべきことについて検討を行った。
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=桑原晴子
kn-aut-sei=桑原
kn-aut-mei=晴子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科
en-keyword=異文化適応
kn-keyword=異文化適応
en-keyword=幼児
kn-keyword=幼児
en-keyword=個の意識
kn-keyword=個の意識
en-keyword=集団の意識
kn-keyword=集団の意識
en-keyword=普遍性の次元でのつながり
kn-keyword=普遍性の次元でのつながり
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=奥付
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=67
end-page=67
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=センター報告投稿要領
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=63
end-page=66
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=資料 : 2018年度
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=23
end-page=55
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=運営 : 2018年度
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=21
end-page=21
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=地域連携 : 2018年度
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=9
end-page=13
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=モモ‘紅清水’における赤肉果の音響振動法による非破壊判別技術の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FukudaFumio
en-aut-sei=Fukuda
en-aut-mei=Fumio
kn-aut-name=福田文夫
kn-aut-sei=福田
kn-aut-mei=文夫
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=近藤毅典
kn-aut-sei=近藤
kn-aut-mei=毅典
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=藤井雄一郎
kn-aut-sei=藤井
kn-aut-mei=雄一郎
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=河井崇
kn-aut-sei=河井
kn-aut-mei=崇
aut-affil-num=4
ORCID=

en-aut-name=HiranoKen
en-aut-sei=Hirano
en-aut-mei=Ken
kn-aut-name=平野健
kn-aut-sei=平野
kn-aut-mei=健
aut-affil-num=5
ORCID=

en-aut-name=MorinagaKunihisa
en-aut-sei=Morinaga
en-aut-mei=Kunihisa
kn-aut-name=森永邦久
kn-aut-sei=森永
kn-aut-mei=邦久
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学農学部附属山陽圏フィールド科学センター

affil-num=2
en-affil=
kn-affil=岡山大学農学部附属山陽圏フィールド科学センター

affil-num=3
en-affil=
kn-affil=岡山県農林水産総合センター農業研究所

affil-num=4
en-affil=
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=5
en-affil=
kn-affil=岡山大学大学院環境生命科学研究科

affil-num=6
en-affil=
kn-affil=岡山大学大学院環境生命科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=9
end-page=19
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=試験研究 : 2018年度
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=1
end-page=6
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=教育 : 2018年度
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=i
end-page=i
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=序
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=吉田裕一
kn-aut-sei=吉田
kn-aut-mei=裕一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=岡山大学農学部附属山陽圏フィールド科学センター
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=47
cd-vols=
no-issue=1
article-no=
start-page=40
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201975
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Pharmacokinetic analysis of new synthetic antimalarial N-251
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background<br>
With the emergence and growing number of drug-resistant Plasmodium falciparum, a new drug for malaria control must be urgently developed. The new antimalarial synthetic compound N-251 was recently discovered. As an endoperoxide structure in the body, the compound shows high antimalarial activity and curative effects. We performed a pharmacokinetic (PK) analysis of N-251 under various conditions using mice to understand the inhibitory effect of N-251 in parasite-infected mice.<br>
<br>
Results<br>
PK study of N-251 after intravenous and oral administration in mice showed plasma concentration of N-251 was decreased drastically by intravenous route. Cmax was reached in 2?h after oral administration of N-251, and the level decreased to a level similar to that obtained after intravenous administration. The area under the curves (AUCs) of the plasma concentration of N-251 increased dose-proportionally in both administrations, and bioavailability (F) was approximately 23%. Additionally, Tmax, Cmax, AUC, and F increased in fasted mice compared to normal-fed mice after the administration of N-251, indicating the influence of diet on the absorption kinetics of N-251. Furthermore, in parasite-infected fasted mice, the plasma concentration-time profile of N-251 was similar to that in normal-fasted mice. Based on the PK parameters of single oral administration of N-251, we investigated the effect of multiple oral doses of N-251 (68?mg/kg three times per day for 2?days) in normal-fed mice. The plasma concentration of N-251 was between 10 and 1000?ng/mL. The simulation curve calculated based on the PK parameters obtained from the single-dose study well described the plasma concentrations after multiple oral dosing, indicating that N-251 did not accumulate in the mice. Multiple oral administrations of N-251 in mice were required to completely eliminate parasites without accumulation of N-251.<br>
<br>
Conclusions<br>
N-251 has been selected as a potent antimalarial candidate. We found that N-251 showed short half-life in plasma, and AUCs increased proportionally to dose. With multiple doses of N-251, the plasma level of N-251 was greater than 10?ng/mL in normal-fed mice, and accumulation of N-251 was not observed; however, multiple treatments with N-251 are required for the complete cure of parasite-infected mice. Determining the appropriate dosage was an important step in the clinical applications of N-251.
en-copyright=
kn-copyright=

en-aut-name=OkadaKazuaki
en-aut-sei=Okada
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SatoAkira
en-aut-sei=Sato
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HiramotoAkiko
en-aut-sei=Hiramoto
en-aut-mei=Akiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IsogawaRena
en-aut-sei=Isogawa
en-aut-mei=Rena
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KurosakiYuji
en-aut-sei=Kurosaki
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HigakiKazutaka
en-aut-sei=Higaki
en-aut-mei=Kazutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyoshiShin-Ichi
en-aut-sei=Miyoshi
en-aut-mei=Shin-Ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ChangKyung-Soo
en-aut-sei=Chang
en-aut-mei=Kyung-Soo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KimHye-Sook
en-aut-sei=Kim
en-aut-mei=Hye-Sook
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Division of International Infectious Diseases Control, Faculty of Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Division of International Infectious Diseases Control, Faculty of Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Division of International Infectious Diseases Control, Faculty of Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=
kn-affil=

affil-num=6
en-affil=
kn-affil=

affil-num=7
en-affil=
kn-affil=

affil-num=8
en-affil=
kn-affil=

affil-num=9
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=6
article-no=
start-page=510
end-page=512
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Treatment of Bucco-Accessory Root Canal of a Maxillary Incisor with a Combination of Cone Beam Computed Tomography and Continuous Supersonic Wave Condensation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective: A novel treatment for bucco-accessory root canal (bARC), which is difficult to treat by regular endodontic therapy, is discussed.<br>
Clinical Presentation and Intervention: A bARC in the maxillary right incisor with symptomatic irreversible pulpitis was detected using cone beam computed tomography (CBCT) after conventional dental radiography. The pulp was extirpated and the canal enlarged using rotary files and chemo-mechanical reagents. The main root canal and bARC were obturated with thermoplastic gutta-percha using continuous wave condensation. Postoperative CBCT revealed a completely treated bARC.<br>
Conclusion: A combination of CBCT and continuous wave condensation is ideal for bARCs in incisors.
en-copyright=
kn-copyright=

en-aut-name=AriasZulema
en-aut-sei=Arias
en-aut-mei=Zulema
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=CazasIvana
en-aut-sei=Cazas
en-aut-mei=Ivana
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=Yasir Dilshad Siddiqui
kn-aut-sei=Yasir Dilshad Siddiqui
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamashiroKeisuke
en-aut-sei=Yamashiro
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakashibaShogo
en-aut-sei=Takashiba
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Mohammad Khursheed Alam
en-aut-sei=Mohammad Khursheed Alam
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Faculty of Dentistry, University Mayor of San Andres
kn-affil=

affil-num=2
en-affil=Private Dental Office
kn-affil=

affil-num=3
en-affil=Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Pathophysiology - Periodontal Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=College of Dentistry, Jouf University
kn-affil=
en-keyword=maxillary incisor
kn-keyword=maxillary incisor
en-keyword=bucco-accessory root canal
kn-keyword=bucco-accessory root canal
en-keyword=cone beam computed tomography
kn-keyword=cone beam computed tomography
en-keyword=continuous supersonic wave condensation
kn-keyword=continuous supersonic wave condensation
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=2
article-no=
start-page=143
end-page=151
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190910
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Future trends of excess mercury in Asia in response to Minamata Convention on Mercury
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Owing to rapid industrialization, Asia has become the main source of mercury emissions and a significant net importer of mercury.<br>
Therefore, the situation regarding excess mercury in Asia needs to be better understood. In this study, mercury flows and excess mercury in 2010?2050 in Asian regions, with a particular focus on China, are assessed under updated assumptions. The excess mercury in China in 2030 and 2050 is estimated to be 125 and 284 tons, respectively. The cumulative excess mercury in China will reach around 10,000 tons in 2050 under the assumption of no export of it in the years 2010?2050. In addition, the year in which mercury reaches a surplus in Asia (excl. China) is estimated to be 2039. The mercury supply in Asia strongly depends on the usage of excess mercury in China. It is estimated that mercury supplies will be insufficient in Asia until at least 2017. These predictions should support decision-making and planning for long-term storage capacity, discussions of regional coordination, securing of technical support, and development of the basic design of related facilities.
en-copyright=
kn-copyright=

en-aut-name=Habuer
en-aut-sei=Habuer
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HamaguchiDaisuke
en-aut-sei=Hamaguchi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ZhouYingjun
en-aut-sei=Zhou
en-aut-mei=Yingjun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujimoriTakashi
en-aut-sei=Fujimori
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakaokaMasaki
en-aut-sei=Takaoka
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Engineering, Kyoto University
kn-affil=

affil-num=3
en-affil=Graduate School of Engineering, Kyoto University
kn-affil=

affil-num=4
en-affil=Graduate School of Engineering, Kyoto University
kn-affil=

affil-num=5
en-affil=Graduate School of Engineering, Kyoto University
kn-affil=
en-keyword=Excess mercury
kn-keyword=Excess mercury
en-keyword=Long-term strategy
kn-keyword=Long-term strategy
en-keyword=Scenario analysis
kn-keyword=Scenario analysis
en-keyword=China
kn-keyword=China
en-keyword=Asia
kn-keyword=Asia
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Report on the Project "Teacher Education for ESD in the Asia-Pacific  Region"
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Outputs of the Asia-Pacific Regional Meeting on Teacher Education for ESD: Towards Achieving the Sustainable Development Goals through Education<br>
27-29 Nobember 2018, Okayama, Japan
en-copyright=
kn-copyright=

en-aut-name=Okayama University ESD Promotion Centre
en-aut-sei=Okayama University ESD Promotion Centre
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=現職教員に対する研修講座・公開セミナー等の修了により教職大学院において単位を授与する制度の導入・プログラム開発
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学大学院教育学研究科 教職実践専攻(教職大学院)
kn-aut-sei=岡山大学大学院教育学研究科 教職実践専攻(教職大学院)
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=
article-no=
start-page=103
end-page=110
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=性的マイノリティ当事者の語りは聴き手の性的マイノリティへの印象や当惑感を改善する
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=本研究の目的は，性的マイノリティ当事者の語りが，聴講者の性的マイノリティへの態度や認識に及ぼす変化を明らかにすることである．当事者が現職の学校教員と校長を対象に50分の講話をし，講演の前後に質問紙調査を行い，印象や当惑感，理解の困難さについて数値化し，変化を調べた．調査内容は，印象の測定にはSD法を使用し，印象の「身近さ」因子に含まれる6項目について7件法で回答を求め，当惑感については8項目，理解困難については2項目の尺度を使用し，6件法で回答を求めた．その結果，参加者は性的マイノリティをより身近に感じるようになり，当惑感や理解困難等の否定的な態度や認識が有意に軽減した．
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=前本浩希
kn-aut-sei=前本
kn-aut-mei=浩希
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=佐々木新
kn-aut-sei=佐々木
kn-aut-mei=新
aut-affil-num=2
ORCID=

en-aut-name=OhmoriIori
en-aut-sei=Ohmori
en-aut-mei=Iori
kn-aut-name=大守伊織
kn-aut-sei=大守
kn-aut-mei=伊織
aut-affil-num=3
ORCID=

affil-num=1
en-affil=岡山大学特別支援教育特別専攻科
kn-affil=

affil-num=2
en-affil=川崎医療福祉大学医療福祉学部
kn-affil=

affil-num=3
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科
en-keyword=自己開示
kn-keyword=自己開示
en-keyword=受容
kn-keyword=受容
en-keyword=性的マイノリティ
kn-keyword=性的マイノリティ
en-keyword=当事者の語り
kn-keyword=当事者の語り
END

start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=1
article-no=
start-page=e143
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191124
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Evaluation of a point-of-care serum creatinine measurement device and the impact on diagnosis of acute kidney injury in pediatric cardiac patients: A retrospective, single center study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background and aims: Agreement between measurements of creatinine concentrations using point-of-care (POC) devices and measurements conducted in a standard central laboratory is unclear for pediatric patients. Our objectives were (a) to assess the agreement for pediatric patients and (b) to compare the incidence of postoperative acute kidney injury (AKI) according to the two methods. <br>
Methods: This retrospective, single-center study included patients under 18 years of age who underwent cardiac surgery and who were admitted into the pediatric intensive care unit of a tertiary teaching hospital (Okayama University Hospital, Japan) from 2013 to 2017. The primary objective was to assess the correlation and the agreement between measurements of creatinine concentrations by a Radiometer blood gas analyzer (Cre(gas)) and those conducted in a central laboratory (Cre(lab)). The secondary objective was to compare the incidence of postoperative AKI between the two methods based on Kidney Disease Improving Global Outcomes (KDIGO) criteria. <br>
Results: We analyzed the results of 1404 paired creatinine measurements from 498 patients, whose median age was 14 months old (interquartile range [IQR] 3, 49). The Pearson correlation coefficient of Cre(gas) vs Cre(lab) was 0.968 (95% confidence interval [CI], 0.965-0.972, P < 0.001). The median bias between Cre(gas) and Cre(lab) was 0.02 (IQR -0.02, 0.05) mg/dL. While 199 patients (40.0%) were diagnosed as having postoperative AKI based on Cre(lab), 357 patients (71.7%) were diagnosed as having postoperative AKI based on Cre(gas) (Kappa = 0.39, 95% CI, 0.33-0.46). In a subgroup analysis of patients whose Cre(gas) and Cre(lab) were measured within 1 hour, similar percentage of patients were diagnosed as having postoperative AKI based on Cre(gas) and Cre(lab) (42.8% vs 46.0%; Kappa = 0.76, 95% CI, 0.68-0.84). <br>
Conclusion: There was an excellent correlation between Cre(gas) and Cre(lab) in pediatric patients. Although more patients were diagnosed as having postoperative AKI based on Cre(gas) than based on Cre(lab), paired measurements with a short time gap showed good agreement on AKI diagnosis.
en-copyright=
kn-copyright=

en-aut-name=KimuraSatoshi
en-aut-sei=Kimura
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IwasakiTatsuo
en-aut-sei=Iwasaki
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShimizuKazuyoshi
en-aut-sei=Shimizu
en-aut-mei=Kazuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KanazawaTomoyuki
en-aut-sei=Kanazawa
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KawaseHirokazu
en-aut-sei=Kawase
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShiojiNaohiro
en-aut-sei=Shioji
en-aut-mei=Naohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KuroeYasutoshi
en-aut-sei=Kuroe
en-aut-mei=Yasutoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IsoyamaSatoshi
en-aut-sei=Isoyama
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Anesthesiology and Resuscitation, Okayama University Hospital
kn-affil=
en-keyword=acute kidney injury
kn-keyword=acute kidney injury
en-keyword=cardiac surgical procedures
kn-keyword=cardiac surgical procedures
en-keyword=children
kn-keyword=children
en-keyword=creatinine
kn-keyword=creatinine
en-keyword=point-of-care
kn-keyword=point-of-care
END

start-ver=1.4
cd-journal=joma
no-vol=970
cd-vols=
no-issue=
article-no=
start-page=609
end-page=620
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201967
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cross-Cultural Analysis of Top Page Design Among Brazilian, Chinese, Japanese and United States Web Sites
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The aim of present study was to reveal the differences of web design including cultural preference among the four countries that have different cultures. Twenty local municipal sites were randomly chosen from United States, Japan, China, and Brazil. The characteristics of these web sites was investigated from viewpoint of the following seven categories: (1) text, (2) layout, (3) navigation, (4) multimedia, (5) links, (6) items location, (7) color. When the web site had each factor, the researcher gave a "1" for that factor. Chi-square goodness-of-fit test was performed to compare the percentage of "0" or "1" of each factor among the four countries. Additionally, the correspondence analysis was performed to grasp the characteristics of each country. The characteristics of the top page design of the four countries were grasped based on these analyses.
en-copyright=
kn-copyright=

en-aut-name=DoiToshihisa
en-aut-sei=Doi
en-aut-mei=Toshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MurataAtsuo
en-aut-sei=Murata
en-aut-mei=Atsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=
kn-affil=
en-keyword=Web design
kn-keyword=Web design
en-keyword=Cultural difference
kn-keyword=Cultural difference
en-keyword=Appearance
kn-keyword=Appearance
en-keyword=Cultural usability
kn-keyword=Cultural usability
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=2
article-no=
start-page=70
end-page=75
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190415
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Recent Changes and Improvements in Multidisciplinary Perioperative Management From a Nutritional Perspective: Dental Specialty Should Be Considered Important
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose of review<br>
Recently, multidisciplinary strategies on accelerated recovery postoperatively have been provided, and management of the perioperative period has changed and improved dramatically. We summarize the enhanced recovery after surgery (ERAS?) protocol and its outcomes from a nutritional perspective. We established the perioperative management center (PERiO), much of whose work contents conform to ERAS?, but intensive dental staff involvement is characteristic. We also summarize its outcomes.<br>
<br>
Recent findings<br>
ERAS? is a multimodal perioperative care pathway designed to achieve early recovery for patients undergoing a major surgery. Nutrition is a key pillar for patient-care. Throughout the perioperative period, oral nutrition is suggested as well as possible. Good outcomes have been reported by a meta-analysis of randomized controlled trials. However, dental staff are not regarded as part of the professional team. PERiO reported good outcomes of care bundles and suggested the importance of dental staff contribution. The Japanese social insurance system began to cover involvements of dental staff for perioperative oral management since 2012. Analysis of the nationwide administrative claims database in Japan concluded that preoperative oral care by a dentist significantly reduced postoperative complications in patients undergoing cancer surgery.<br>
<br>
Summary<br>
Currently, dental staff are not regarded as key professionals of ERAS?, although dental staff can contribute to good outcomes in the perioperative period and PERiO, and consequently the Japanese universal health insurance coverage system covering involvements of dental staff for perioperative oral management showed good outcomes. Therefore, further clinical studies involving the dental specialty should be considered important for perioperative management from nutritional perspectives.
en-copyright=
kn-copyright=

en-aut-name=SogaYoshihiko
en-aut-sei=Soga
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShirakawaYasuhiro
en-aut-sei=Shirakawa
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AshiwaTakako
en-aut-sei=Ashiwa
en-aut-mei=Takako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Divison of Hospital Dentistry, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Division of Nursing, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Perioperative Management Center, Okayama University Hospital,
kn-affil=
en-keyword=perioperative management
kn-keyword=perioperative management
en-keyword= nutrition
kn-keyword= nutrition
en-keyword=dental
kn-keyword=dental
en-keyword=oral management
kn-keyword=oral management
END

start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Okayama University Archaeological Research Center Center report
kn-title=岡山大学埋蔵文化財調査研究センター報 第61号
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Archaeological Research Center, Okayama University
en-aut-sei=Archaeological Research Center, Okayama University
en-aut-mei=
kn-aut-name=岡山大学埋蔵文化財調査研究センター
kn-aut-sei=岡山大学埋蔵文化財調査研究センター
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=62
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019126
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Okayama University Archaeological Research Center Center report
kn-title=岡山大学埋蔵文化財調査研究センター報 第62号
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=Archaeological Research Center, Okayama University
en-aut-sei=Archaeological Research Center, Okayama University
en-aut-mei=
kn-aut-name=岡山大学埋蔵文化財調査研究センター
kn-aut-sei=岡山大学埋蔵文化財調査研究センター
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=
article-no=
start-page=093056
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190924
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Superconductivity in a new layered triangular-lattice system Li2IrSi2
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report on the crystal structure and superconducting properties of a novel iridium-silicide, namely Li2IrSi2. It has a Ag2NiO2-type structure (space group R-3m) with the lattice parameters a = 4.028 30(6) ? and c = 13.161 80(15) ?. The crystal structure comprises IrSi2 and double Li layers stacked alternately along the c-axis. The IrSi2 layer includes a two-dimensional Ir equilateral-triangular lattice. Electrical resistivity and static magnetic measurements revealed that Li2IrSi2 is a type-II superconductor with critical temperature (Tc) of 3.3 K. We estimated the following superconducting parameters: lower critical field Hc1(0) ~ 42 Oe, upper critical field Hc2(0) ~ 1.7 kOe, penetration depth λ0 ~ 265 nm, coherence length ξ0 ~ 44 nm, and Ginzburg?Landau parameter κGL ~ 6.02. The specific-heat data suggested that superconductivity in Li2IrSi2 could be attributed to weak-coupling Cooper pairs.
en-copyright=
kn-copyright=

en-aut-name=HoriganeK
en-aut-sei=Horigane
en-aut-mei=K
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakeuchiK
en-aut-sei=Takeuchi
en-aut-mei=K
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HyakumuraD
en-aut-sei=Hyakumura
en-aut-mei=D
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HorieR
en-aut-sei=Horie
en-aut-mei=R
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SatoT
en-aut-sei=Sato
en-aut-mei=T
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MuranakaT
en-aut-sei=Muranaka
en-aut-mei=T
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawashimaK
en-aut-sei=Kawashima
en-aut-mei=K
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IshiiH
en-aut-sei=Ishii
en-aut-mei=H
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KubozonoY
en-aut-sei=Kubozono
en-aut-mei=Y
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OrimoS
en-aut-sei=Orimo
en-aut-mei=S
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=IsobeM
en-aut-sei=Isobe
en-aut-mei=M
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=AkimitsuJ
en-aut-sei=Akimitsu
en-aut-mei=J
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University,
kn-affil=

affil-num=2
en-affil=Graduate School of natural science and technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Physics and Mathematics, Aoyama Gakuin University
kn-affil=

affil-num=4
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=5
en-affil=Institute for Materials Research, Tohoku University
kn-affil=

affil-num=6
en-affil=Department of Engineering Science, University of Electro-Communications
kn-affil=

affil-num=7
en-affil=Department of Physics and Mathematics, Aoyama Gakuin University
kn-affil=

affil-num=8
en-affil=National Synchrotron Radiation Research Center
kn-affil=

affil-num=9
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=10
en-affil=Institute for Materials Research, Tohoku University
kn-affil=

affil-num=11
en-affil=National Institute for Materials Science (NIMS)
kn-affil=

affil-num=12
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
en-keyword=supreconductivity
kn-keyword=supreconductivity
en-keyword=iridium-silicide
kn-keyword=iridium-silicide
en-keyword=spin?orbit coupling
kn-keyword=spin?orbit coupling
END

start-ver=1.4
cd-journal=joma
no-vol=46
cd-vols=
no-issue=9
article-no=
start-page=1773
end-page=1786
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190530
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The next era of renal radionuclide imaging: novel PET radiotracers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although single-photon-emitting radiotracers have long been the standard for renal functional molecular imaging, recent years have seen the development of positron emission tomography (PET) agents for this application. We provide an overview of renal radionuclide PET radiotracers, in particular focusing on novel 18F-labelled and 68Ga-labelled agents. Several reported PET imaging probes allow assessment of glomerular filtration rate, such as [68Ga]ethylenediaminetetraacetic acid ([68Ga]EDTA), [68Ga]IRDye800-tilmanocept and 2-deoxy-2-[18F]fluorosorbitol ([18F]FDS)). The diagnostic performance of [68Ga]EDTA has already been demonstrated in a clinical trial. [68Ga]IRDye800-tilmanocept shows receptor-mediated binding to glomerular mesangial cells, which in turn may allow the monitoring of progression of diabetic nephropathy. [18F]FDS shows excellent kidney extraction and excretion in rats and, as has been shown in the first study in humans. Further, due to its simple one-step radiosynthesis via the most frequently used PET radiotracer 2-deoxy-2-[18F]fluoro-d-glucose, [18F]FDS could be available at nearly every PET centre. A new PET radiotracer has also been introduced for the effective assessment of plasma flow in the kidneys: Re(CO)3-N-([18F]fluoroethyl)iminodiacetic acid (Re(CO)3([18F]FEDA)). This compound demonstrates similar pharmacokinetic properties to its 99mTc-labelled analogue [99mTc](CO)3(FEDA). Thus, if there is a shortage of molybdenum-99, Re(CO)3([18F]FEDA would allow direct comparison with previous studies with 99mTc. The PET radiotracers for renal imaging reviewed here allow thorough evaluation of kidney function, with the tremendous advantage of precise anatomical coregistration with simultaneously acquired CT images and rapid three-dimensional imaging capability.
en-copyright=
kn-copyright=

en-aut-name=WernerRudolf A.
en-aut-sei=Werner
en-aut-mei=Rudolf A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ChenXinyu
en-aut-sei=Chen
en-aut-mei=Xinyu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=LapaConstantin
en-aut-sei=Lapa
en-aut-mei=Constantin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KoshinoKazuhiro
en-aut-sei=Koshino
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=RoweSteven P.
en-aut-sei=Rowe
en-aut-mei=Steven P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=PomperMartin G.
en-aut-sei=Pomper
en-aut-mei=Martin G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=JavadiMehrbod S.
en-aut-sei=Javadi
en-aut-mei=Mehrbod S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HiguchiTakahiro
en-aut-sei=Higuchi
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Nuclear Medicine/Comprehensive Heart Failure Center, University of Wuerzburg
kn-affil=

affil-num=2
en-affil=Department of Nuclear Medicine/Comprehensive Heart Failure Center, University of Wuerzburg
kn-affil=

affil-num=3
en-affil=Department of Nuclear Medicine/Comprehensive Heart Failure Center, University of Wuerzburg
kn-affil=

affil-num=4
en-affil=Department of Biomedical Imaging, National Cardiovascular and Cerebral Center
kn-affil=

affil-num=5
en-affil=Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine
kn-affil=

affil-num=6
en-affil=
kn-affil=

affil-num=7
en-affil=Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine
kn-affil=

affil-num=8
en-affil=Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School
kn-affil=
en-keyword=Kidney
kn-keyword=Kidney
en-keyword=Positron emission tomography
kn-keyword=Positron emission tomography
en-keyword=PET
kn-keyword=PET
en-keyword=[18F]Fluorodeoxysorbitol
kn-keyword=[18F]Fluorodeoxysorbitol
en-keyword=GFR
kn-keyword=GFR
en-keyword=ERPF
kn-keyword=ERPF
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=3
article-no=
start-page=598
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Region-Specific Neuroprotective Features of Astrocytes against Oxidative Stress Induced by 6-Hydroxydopamine 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In previous studies, we found regional differences in the induction of antioxidative molecules in astrocytes against oxidative stress, postulating that region-specific features of astrocytes lead region-specific vulnerability of neurons. We examined region-specific astrocytic features against dopaminergic neurotoxin 6-hydroxydopamine (6-OHDA) as an oxidative stress using co-culture of mesencephalic neurons and mesencephalic or striatal astrocytes in the present study. The 6-OHDA-induced reduction of mesencephalic dopamine neurons was inhibited by co-culturing with astrocytes. The co-culture of midbrain neurons with striatal astrocytes was more resistant to 6-OHDA than that with mesencephalic astrocytes. Furthermore, glia conditioned medium from 6-OHDA-treated striatal astrocytes showed a greater protective effect on the 6-OHDA-induced neurotoxicity and oxidative stress than that from mesencephalic astrocytes. The cDNA microarray analysis showed that the number of altered genes in both mesencephalic and striatal astrocytes was fewer than that changed in either astrocyte. The 6-OHDA treatment, apparently up-regulated expressions of Nrf2 and some anti-oxidative or Nrf2-regulating phase II, III detoxifying molecules related to glutathione synthesis and export in the striatal astrocytes but not mesencephalic astrocytes. There is a profound regional difference of gene expression in astrocytes induced by 6-OHDA. These results suggest that protective features of astrocytes against oxidative stress are more prominent in striatal astrocytes, possibly by secreting humoral factors in striatal astrocytes.
en-copyright=
kn-copyright=

en-aut-name=AsanumaMasato
en-aut-sei=Asanuma
en-aut-mei=Masato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Okumura-TorigoeNao
en-aut-sei=Okumura-Torigoe
en-aut-mei=Nao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MiyazakiIkuko
en-aut-sei=Miyazaki
en-aut-mei=Ikuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MurakamiShinki
en-aut-sei=Murakami
en-aut-mei=Shinki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medical, Dental and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medical, Dental and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medical, Dental and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Medical Neurobiology, Okayama University Graduate School of Medical, Dental and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medical, Dental and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medical, Dental and Pharmaceutical Sciences
kn-affil=
en-keyword=astrocyte
kn-keyword=astrocyte
en-keyword=neuroprotection
kn-keyword=neuroprotection
en-keyword=region-specificity
kn-keyword=region-specificity
en-keyword=striatum
kn-keyword=striatum
en-keyword=mesencephalon
kn-keyword=mesencephalon
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=6-hydroxydopamine
kn-keyword=6-hydroxydopamine
en-keyword=Nrf2
kn-keyword=Nrf2
en-keyword=phase II detoxifying molecules
kn-keyword=phase II detoxifying molecules
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=1
article-no=
start-page=2045894019831217
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190215
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Improvement of lung function and pulmonary hypertension after pulmonary aneurysm repair: case series 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Pulmonary artery aneurysms (PAA) can be complicated with pulmonary arterial hypertension (PAH), causing sudden death due to PA rupture and dissection. Because treatment with PAH-targeted drugs does not always prevent PAA progression, prophylactic surgical repair of the PAA seems a promising alternative. However, although it avoids rupture and dissection of the PAs, additional benefits have not been forthcoming. We therefore present two patients with co-existing PAH and a PAA who underwent surgical repair of the aneurysm. Following the surgery, their lung function and pulmonary hypertension improved. Optimal treatment of PAA remains uncertain, however, with no clear guidelines regarding the best therapeutic approach. This case series provides physicians with reasons to repair PAA surgically in patients with PAH.
en-copyright=
kn-copyright=

en-aut-name=AkagiSatoshi
en-aut-sei=Akagi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EjiriKentaro
en-aut-sei=Ejiri
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KasaharaShingo
en-aut-sei=Kasahara
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakamuraKazufumi
en-aut-sei=Nakamura
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=3
en-affil=Department of Cardiovascular Surgery, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=

affil-num=5
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science
kn-affil=
en-keyword=vital capacity
kn-keyword=vital capacity
en-keyword=pulmonary artery pressure
kn-keyword=pulmonary artery pressure
en-keyword=lung perfusion and oxygenation
kn-keyword=lung perfusion and oxygenation
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=21
article-no=
start-page=3163
end-page=3165
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Spastic Paraplegia Accompanied by Extrapyramidal Sign and Frontal Cognitive Dysfunction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A complicated form of spastic paraplegia is a neurodegenerative disorder presenting as progressive spasticity in the bilateral lower limbs accompanied by some clinical features. The present case showed spastic paralysis and hyperreflexia in all extremities as well as lead pipe rigidity in the neck and bilateral upper extremities (R < L), decreased scores on frontal cognitive tests, a decreased accumulation of the right dorsal putamen on a DAT scan, and hypoperfusion of the bilateral frontal lobes on 99mTc-ECD single photon emission computed tomography (SPECT). The present case provides a new spectrum of spastic paraplegia based on the evidence of clinical scores and the findings of brain functional imaging.
en-copyright=
kn-copyright=

en-aut-name=SasakiRyo
en-aut-sei=Sasaki
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhtaYasuyuki
en-aut-sei=Ohta
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatoKota
en-aut-sei=Sato
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TadokoroKoh
en-aut-sei=Tadokoro
en-aut-mei=Koh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakahashiYoshiaki
en-aut-sei=Takahashi
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShangJingwei
en-aut-sei=Shang
en-aut-mei=Jingwei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakemotoMami
en-aut-sei=Takemoto
en-aut-mei=Mami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HishikawaNozomi
en-aut-sei=Hishikawa
en-aut-mei=Nozomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamashitaToru
en-aut-sei=Yamashita
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IshiuraHiroyuki
en-aut-sei=Ishiura
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=TsujiShoji
en-aut-sei=Tsuji
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=AbeKoji
en-aut-sei=Abe
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Neurology, The University of Tokyo Hospital
kn-affil=

affil-num=11
en-affil=Department of Molecular Neurology, The University of Tokyo Hospital, Japan  Institute of Medical Genomics, International University of Health and Welfare
kn-affil=

affil-num=12
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=spastic paraplegia
kn-keyword=spastic paraplegia
en-keyword=extrapyramidal sign
kn-keyword=extrapyramidal sign
en-keyword=frontal cognitive dysfunction
kn-keyword=frontal cognitive dysfunction
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=7
article-no=
start-page=1033
end-page=1036
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Characteristic Clinical Features of Werner Syndrome with a Novel Compound Heterozygous WRN Mutation c.1720+1G>A Plus c.3139-1G>C
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Werner syndrome (WS) is an autosomal recessive progeroid disorder caused by mutations in the WRN gene (WRN). Most Japanese WS patients are born from a consanguineous marriage with homozygous WRN mutations. We herein report a rare WS patient born from non-consanguineous parents with compound heterozygous WRN mutations with a novel heterogeneous c.1720+1G>A substitution plus the most frequent heterogeneous c.3139-1G>C substitution among Japanese. Although the present case showed clinical characteristics common to previous Japanese WS patients, he had not developed any malignant tumors as of 43 years of age, suggesting that WS patients with this particular genetic mutation have a different phenotype than others. 
en-copyright=
kn-copyright=

en-aut-name=MatsumotoNamiko
en-aut-sei=Matsumoto
en-aut-mei=Namiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhtaYasuyuki
en-aut-sei=Ohta
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=DeguchiKentaro
en-aut-sei=Deguchi
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KishidaMasayuki
en-aut-sei=Kishida
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SatoKota
en-aut-sei=Sato
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShangJingwei
en-aut-sei=Shang
en-aut-mei=Jingwei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakemotoMami
en-aut-sei=Takemoto
en-aut-mei=Mami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HishikawaNozomi
en-aut-sei=Hishikawa
en-aut-mei=Nozomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamashitaToru
en-aut-sei=Yamashita
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=WatanabeAki
en-aut-sei=Watanabe
en-aut-mei=Aki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=YokoteKoutaro
en-aut-sei=Yokote
en-aut-mei=Koutaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=TakemotoMinoru
en-aut-sei=Takemoto
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=OshimaJunko
en-aut-sei=Oshima
en-aut-mei=Junko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=AbeKoji
en-aut-sei=Abe
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Neurology, Okayama Citizen's Hospital
kn-affil=

affil-num=4
en-affil=Department of General Internal Medicine, Okayama Citizen's Hospital
kn-affil=

affil-num=5
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=11
en-affil=Department of Clinical Cell Biology and Medicine, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=12
en-affil=Department of Diabetes, Metabolism and Endocrinology, School of Medicine, International University of Health and Welfare
kn-affil=

affil-num=13
en-affil=Department of Pathology, University of Washington
kn-affil=

affil-num=14
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=werner syndrome
kn-keyword=werner syndrome
en-keyword=compound heterozygous
kn-keyword=compound heterozygous
en-keyword=Japanese
kn-keyword=Japanese
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=3
article-no=
start-page=437
end-page=440
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Rare Case of Klinefelter Syndrome Accompanied by Spastic Paraplegia and Peripheral Neuropathy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Klinefelter syndrome is a chromosomal disorder with a typical karyotype of 47, XXY, accompanied by various neurological symptoms. We herein report the first case of Klinefelter syndrome with a rare mosaic form of 47, XXY and 48, XXXY, combined with both spastic paraplegia and peripheral motor neuropathy. This case showed spasticity and hyperreflexia with pathological reflexes and ankle clonus as well as muscle weakness in all extremities. A motor nerve conduction study and the magnetic motor evoked potential suggested motor axonal neuropathy and corticospinal tract disorders. The present case suggests that Klinefelter syndrome can present with both upper and lower motor neuron degeneration. 
en-copyright=
kn-copyright=

en-aut-name=SasakiRyo
en-aut-sei=Sasaki
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhtaYasuyuki
en-aut-sei=Ohta
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakahashiYoshiaki
en-aut-sei=Takahashi
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsunodaKeiichiro
en-aut-sei=Tsunoda
en-aut-mei=Keiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TadokoroKoh
en-aut-sei=Tadokoro
en-aut-mei=Koh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SatoKota
en-aut-sei=Sato
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ShangJingwei
en-aut-sei=Shang
en-aut-mei=Jingwei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakemotoMami
en-aut-sei=Takemoto
en-aut-mei=Mami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HishikawaNozomi
en-aut-sei=Hishikawa
en-aut-mei=Nozomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamashitaToru
en-aut-sei=Yamashita
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AbeKoji
en-aut-sei=Abe
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Klinefelter syndrome
kn-keyword=Klinefelter syndrome
en-keyword=mosaic form
kn-keyword=mosaic form
en-keyword=peripheral neuropathy
kn-keyword=peripheral neuropathy
en-keyword=spastic paraplegia
kn-keyword=spastic paraplegia
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=8
article-no=
start-page=1081
end-page=1085
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190415
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Improving Anxiety in Subacute Myelo-optico-neuropathy (SMON) after an Automated Telephone Call Service
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective We evaluated the clinical effects of a telephone call service for psychological symptoms such as anxiety, depression or apathy in subacute myelo-optico-neuropathy (SMON) patients living alone or with a single caregiver. </br>
Methods Up to 16 SMON patients (4 men, 12 women) and 32 control subjects were evaluated by the geriatric depression scale (GDS), apathy scale (AS) and state and trait anxiety inventory (STAI) forms X-I, including the P and A values for depression, apathy and state anxiety including disturbed peace of mind and enhanced anxiety, respectively, before (pre) and three months after (post) the telephone call service. </br>
Results The SMON patients, especially women, had significantly worse baseline scores in GDS (depression), AS (apathy) and STAI (state anxiety) than control subjects. The automated telephone call service significantly improved the high baseline STAI scores, including the P and A scores (disturbed peace of mind and enhanced anxiety), of SMON patients but not the GDS or AS scores. </br>
Conclusion SMON patients, especially women, living alone or with a single caregiver showed higher baseline depression, apathy and anxiety scores than the control subjects. The present automated telephone call service proved to be a useful care tool for improving the anxiety of SMON patients with high STAI P and A scores. 
en-copyright=
kn-copyright=

en-aut-name=OhtaYasuyuki
en-aut-sei=Ohta
en-aut-mei=Yasuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HishikawaNozomi
en-aut-sei=Hishikawa
en-aut-mei=Nozomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SatoKota
en-aut-sei=Sato
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakemotoMami
en-aut-sei=Takemoto
en-aut-mei=Mami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YamashitaToru
en-aut-sei=Yamashita
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=DoutareShinji
en-aut-sei=Doutare
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=AbeKoji
en-aut-sei=Abe
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Doutare Medical Clinic
kn-affil=

affil-num=7
en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=anxiety
kn-keyword=anxiety
en-keyword=SMON
kn-keyword=SMON
en-keyword=STAI
kn-keyword=STAI
en-keyword=telephone call service
kn-keyword=telephone call service
END

start-ver=1.4
cd-journal=joma
no-vol=89
cd-vols=
no-issue=1
article-no=
start-page=012001
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191212
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sparse Modeling in Quantum Many-Body Problems
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This review paper describes the basic concept and technical details of sparse modeling and its applications to quantum many-body problems. Sparse modeling refers to methodologies for finding a small number of relevant parameters that well explain a given dataset. This concept reminds us physics, where the goal is to find a small number of physical laws that are hidden behind complicated phenomena. Sparse modeling extends the target of physics from natural phenomena to data, and may be interpreted as “physics for data”. The first half of this review introduces sparse modeling for physicists. It is assumed that readers have physics background but no expertise in data science. The second half reviews applications. Matsubara Green’s function, which plays a central role in descriptions of correlated systems, has been found to be sparse, meaning that it contains little information. This leads to (i) a new method for solving the ill-conditioned inverse problem for analytical continuation, and (ii) a highly compact representation of Matsubara Green’s function, which enables efficient calculations for quantum many-body systems.
en-copyright=
kn-copyright=

en-aut-name=OtsukiJunya
en-aut-sei=Otsuki
en-aut-mei=Junya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhzekiMasayuki
en-aut-sei=Ohzeki
en-aut-mei=Masayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShinaokaHiroshi
en-aut-sei=Shinaoka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YoshimiKazuyoshi
en-aut-sei=Yoshimi
en-aut-mei=Kazuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Information Sciences, Tohoku University
kn-affil=

affil-num=3
en-affil=Department of Physics, Saitama University
kn-affil=

affil-num=4
en-affil=4Institute for Solid State Physics, University of Tokyo
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=11
article-no=
start-page=1858
end-page=1865
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191224
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An investigation of seasonal variations in the microbiota of milk, feces, bedding, and airborne dust
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective</br>
The microbiota of dairy cow milk varies with the season, and this accounts in part for the seasonal variation in mastitis-causing bacteria and milk spoilage. The microbiota of the cowshed may be the most important factor because the teats of a dairy cow contact bedding material when the cow is resting. The objectives of the present study were to determine whether the microbiota of the milk and the cowshed vary between seasons, and to elucidate the relationship between the microbiota.</br>
Methods</br>
We used 16S rRNA gene amplicon sequencing to investigate the microbiota of milk, feces, bedding, and airborne dust collected at a dairy farm during summer and winter.</br>
Results</br>
The seasonal differences in the milk yield and milk composition were marginal. The fecal microbiota was stable across the two seasons. Many bacterial taxa of the bedding and airborne dust microbiota exhibited distinctive seasonal variation. In the milk microbiota, the abundances of Staphylococcaceae, Bacillaceae, Streptococcaceae, Microbacteriaceae, and Micrococcaceae were affected by the seasons; however, only Micrococcaceae had the same seasonal variation pattern as the bedding and airborne dust microbiota. Nevertheless, canonical analysis of principle coordinates revealed a distinctive group comprising the milk, bedding, and airborne dust microbiota.</br>
Conclusion</br>
Although the milk microbiota is related to the bedding and airborne dust microbiota, the relationship may not account for the seasonal variation in the milk microbiota. Some major bacterial families stably found in the bedding and airborne dust microbiota, e.g., Staphylococcaceae, Moraxellaceae, Ruminococcaceae, and Bacteroidaceae, may have greater influences than those that varied between seasons.
en-copyright=
kn-copyright=

en-aut-name=NguyenThuong Thi
en-aut-sei=Nguyen
en-aut-mei=Thuong Thi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WuHaoming
en-aut-sei=Wu
en-aut-mei=Haoming
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishinoNaoki
en-aut-sei=Nishino
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=Cowshed
kn-keyword=Cowshed
en-keyword=Dairy Cow
kn-keyword=Dairy Cow
en-keyword=Microbiota
kn-keyword=Microbiota
en-keyword=Milk
kn-keyword=Milk
en-keyword=Season
kn-keyword=Season
END

start-ver=1.4
cd-journal=joma
no-vol=30
cd-vols=
no-issue=3
article-no=
start-page=1342
end-page=1349
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191126
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Robotic CT-guided out-of-plane needle insertion: comparison of angle accuracy with manual insertion in phantom and measurement of distance accuracy in animals
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives</br>
To evaluate the accuracy of robotic CT-guided out-of-plane needle insertion in phantom and animal experiments.</br>
Methods</br>
A robotic system (Zerobot), developed at our institution, was used for needle insertion. In the phantom experiment, 12 robotic needle insertions into a phantom at various angles in the XY and YZ planes were performed, and the same insertions were manually performed freehand, as well as guided by a smartphone application (SmartPuncture). Angle errors were compared between the robotic and smartphone-guided manual insertions using Student’s t test. In the animal experiment, 6 robotic out-of-plane needle insertions toward targets of 1.0 mm in diameter placed in the kidneys and hip muscles of swine were performed, each with and without adjustment of needle orientation based on reconstructed CT images during insertion. Distance accuracy was calculated as the distance between the needle tip and the target center.</br>
Results</br>
In the phantom experiment, the mean angle errors of the robotic, freehand manual, and smartphone-guided manual insertions were 0.4°, 7.0°, and 3.7° in the XY plane and 0.6°, 6.3°, and 0.6° in the YZ plane, respectively. Robotic insertions in the XY plane were significantly (p < 0.001) more accurate than smartphone-guided insertions. In the animal experiment, the overall mean distance accuracy of robotic insertions with and without adjustment of needle orientation was 2.5 mm and 5.0 mm, respectively.</br>
Conclusion</br>
Robotic CT-guided out-of-plane needle insertions were more accurate than smartphone-guided manual insertions in the phantom and were also accurate in the in vivo procedure, particularly with adjustment during insertion.
en-copyright=
kn-copyright=

en-aut-name=KomakiToshiyuki
en-aut-sei=Komaki
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HirakiTakao
en-aut-sei=Hiraki
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KamegawaTetsushi
en-aut-sei=Kamegawa
en-aut-mei=Tetsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MatsunoTakayuki
en-aut-sei=Matsuno
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakuraiJun
en-aut-sei=Sakurai
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsuuraRyutaro
en-aut-sei=Matsuura
en-aut-mei=Ryutaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamaguchiTakuya
en-aut-sei=Yamaguchi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SasakiTakanori
en-aut-sei=Sasaki
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OkamotoSoichiro
en-aut-sei=Okamoto
en-aut-mei=Soichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=UkaMayu
en-aut-sei=Uka
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=MatsuiYusuke
en-aut-sei=Matsui
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IguchiToshihiro
en-aut-sei=Iguchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=GobaraHideo
en-aut-sei=Gobara
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KanazawaSusumu
en-aut-sei=Kanazawa
en-aut-mei=Susumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Department of Radiology, Okayama University Medical School
kn-affil=

affil-num=2
en-affil=Department of Radiology, Okayama University Medical School
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Graduate School of Health Sciences, Okayama University Medical School
kn-affil=

affil-num=7
en-affil=Division of Radiology, Department of Medical Technology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Collaborative Research Center for OMIC, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Radiology, Okayama University Medical School
kn-affil=

affil-num=11
en-affil=Department of Radiology, Okayama University Medical School
kn-affil=

affil-num=12
en-affil=Department of Radiology, Okayama University Medical School
kn-affil=

affil-num=13
en-affil=Department of Radiology, Okayama University Medical School
kn-affil=

affil-num=14
en-affil=Division of Medical Informatics, Okayama University Hospital
kn-affil=

affil-num=15
en-affil=Department of Radiology, Okayama University Medical School
kn-affil=
en-keyword=Robotics
kn-keyword=Robotics
en-keyword=Interventional radiology
kn-keyword=Interventional radiology
en-keyword=Animal experiments
kn-keyword=Animal experiments
END

start-ver=1.4
cd-journal=joma
no-vol=22
cd-vols=
no-issue=3
article-no=
start-page=602
end-page=611
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190722
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Initial Evaluation of AF78: a Rationally Designed Fluorine-18-Labelled PET Radiotracer Targeting Norepinephrine Transporter
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose</br>
Taking full advantage of positron emission tomography (PET) technology, fluorine-18-labelled radiotracers targeting norepinephrine transporter (NET) have potential applications in the diagnosis and assessment of cardiac sympathetic nerve conditions as well as the delineation of neuroendocrine tumours. However, to date, none have been used clinically. Drawbacks of currently reported radiotracers include suboptimal kinetics and challenging radiolabelling procedures.</br>
Procedures</br>
We developed a novel fluorine-18-labelled radiotracer targeting NET, AF78, with efficient one-step radiolabelling based on the phenethylguanidine structure. Radiosynthesis of AF78 was undertaken, followed by validation in cell uptake studies, autoradiography, and in vivo imaging in rats.</br>
Results</br>
[18F]AF78 was successfully synthesized with 27.9?±?3.1 % radiochemical yield, >?97 % radiochemical purity and >?53.8 GBq/mmol molar activity. Cell uptake studies demonstrated essentially identical affinity for NET as norepinephrine and meta-iodobenzylgaunidine. Both ex vivo autoradiography and in vivo imaging in rats showed homogeneous and specific cardiac uptake.</br>
Conclusions</br>
The new PET radiotracer [18F]AF78 demonstrated high affinity for NET and favourable biodistribution in rats. A structure-activity relationship between radiotracer structures and affinity for NET was revealed, which may serve as the basis for the further design of NET targeting radiotracers with favourable features.
en-copyright=
kn-copyright=

en-aut-name=ChenXinyu
en-aut-sei=Chen
en-aut-mei=Xinyu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FritzAlexander
en-aut-sei=Fritz
en-aut-mei=Alexander
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WernerRudolf A.
en-aut-sei=Werner
en-aut-mei=Rudolf A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NoseNaoko
en-aut-sei=Nose
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YagiYusuke
en-aut-sei=Yagi
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KimuraHiroyuki
en-aut-sei=Kimura
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=RoweSteven P.
en-aut-sei=Rowe
en-aut-mei=Steven P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KoshinoKazuhiro
en-aut-sei=Koshino
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=DeckerMichael
en-aut-sei=Decker
en-aut-mei=Michael
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HiguchiTakahiro
en-aut-sei=Higuchi
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Nuclear Medicine, University Hospital of W?rzburg
kn-affil=

affil-num=2
en-affil=Institute of Pharmacy and Food Chemistry, University of W?rzburg
kn-affil=

affil-num=3
en-affil=Department of Nuclear Medicine, University Hospital of W?rzburg
kn-affil=

affil-num=4
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences, Kyoto Pharmaceutical University
kn-affil=

affil-num=6
en-affil=Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences, Kyoto Pharmaceutical University
kn-affil=

affil-num=7
en-affil=Division of Nuclear Medicine and Molecular Imaging, Russel H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Systems and Informatics, Hokkaido Information University
kn-affil=

affil-num=9
en-affil=Institute of Pharmacy and Food Chemistry, University of W?rzburg
kn-affil=

affil-num=10
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Norepinephrine transporter
kn-keyword=Norepinephrine transporter
en-keyword=Positron emission tomography
kn-keyword=Positron emission tomography
en-keyword=Phenethylguanidine
kn-keyword=Phenethylguanidine
en-keyword=[18F]AF78
kn-keyword=[18F]AF78
END

start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=9
article-no=
start-page=E265
end-page=E266
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201909
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Successful removal of impacted large bile duct stones using electrohydraulic lithotripsy with an ultraslim endoscope after Billroth II gastrectomy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The diagnostic and therapeutic effectiveness of combined double-balloon endoscopy (DBE) using a short endoscope and peroral direct cholangioscopy with an ultraslim endoscope for altered gastrointestinal anatomy has been demonstrated [1][2][3][4][5]. This method offers the following advantages over mother?baby cholangioscopy for bile duct stone treatment: single-operator use, wide working channel, favourable cost performance, and high image resolution. We treated impacted large bile duct stones using electrohydraulic lithotripsy (EHL) and an ultraslim endoscope in a patient who had undergone Billroth II gastrectomy.</br>
A 75-year-old man was referred to our hospital for treatment of bile duct stones. He had undergone Billroth II gastrectomy for gastric cancer. Complete stone removal at the previous hospital was difficult, and a plastic stent had been placed. Abdominal computed tomography showed large stones stuck in the bile duct (largest stone diameter, 25?mm) ([Fig.?1]). We therefore planned to use EHL to crush the stones ([Video?1]).
en-copyright=
kn-copyright=

en-aut-name=MatsumotoKazuyuki
en-aut-sei=Matsumoto
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HoriguchiShigeru
en-aut-sei=Horiguchi
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UchidaDaisuke
en-aut-sei=Uchida
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TomodaTakeshi
en-aut-sei=Tomoda
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MuroShinichiro
en-aut-sei=Muro
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil= Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil= Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil= Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil= Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil= Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil= Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil= Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=31
cd-vols=
no-issue=S1
article-no=
start-page=67
end-page=68
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201904
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Current problems and clinical results of endoscopic necrosectomy for walled‐off pancreatic necrosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsumotoKazuyuki
en-aut-sei=Matsumoto
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=51
cd-vols=
no-issue=7
article-no=
start-page=1060
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201907
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Adenomyomatosis hyperplasia arising in the bile duct
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MatsumotoKazuyuki
en-aut-sei=Matsumoto
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishidaKenji
en-aut-sei=Nishida
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=11
article-no=
start-page=3405
end-page=3415
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190626
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Medial meniscus posterior root tear causes swelling of the medial meniscus and expansion of the extruded meniscus: a comparative analysis between 2D and 3D MRI
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose</br>
This study aimed to clarify the advantages of three-dimensional (3D) magnetic resonance imaging (MRI) over two-dimensional (2D) MRI in measuring the size of the medial meniscus (MM) and to analyse the volumes of MM and the extruded meniscus in patients with MM posterior root tear (MMPRT), at 10° and 90° knee flexion.</br>
Methods</br>
This study included 17 patients with MMPRTs and 15 volunteers with uninjured knees. The MMs were manually segmented for 3D reconstruction; thereafter, the extruded part separated from the tibial edge was determined. The length, width, height, and extrusion of MM were measured by the 2D and 3D methods, and compared. The MM volume, extruded meniscus volume, and their ratio were also calculated using 3D analysis software in the two groups.</br>
Results</br>
The estimated length and posterior height of MM were larger with 3D MRI than with 2D MRI measurements. The MM volume was significantly greater in MMPRT knees than in normal knees, with increasing MM height. In MMPRT knees, the mean volume of the extruded meniscus and its ratio significantly increased by 304 mm3 (p?=?0.02) and 9.1% (p?<?0.01), respectively, during knee flexion.</br>
Conclusions</br>
This study demonstrated that 3D MRI could estimate the precise MM size and that MMPRT caused swelling of the meniscus due to the increased thickness in the posteromedial part. The clinical significance of this study lies in its 3D evaluation of MM volume, which should help the surgeon understand the biomechanical failure of MM function and improve MMPRT repair technique.
en-copyright=
kn-copyright=

en-aut-name=OkazakiYoshiki
en-aut-sei=Okazaki
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamaguchiTakuya
en-aut-sei=Yamaguchi
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KodamaYuya
en-aut-sei=Kodama
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamatsukiYusuke
en-aut-sei=Kamatsuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MasudaShin
en-aut-sei=Masuda
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HiranakaTakaaki
en-aut-sei=Hiranaka
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ZhangXiming
en-aut-sei=Zhang
en-aut-mei=Ximing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School
kn-affil=

affil-num=3
en-affil=Division of Radiology, Medical Technology Department, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Iwakuni Medical Center
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School
kn-affil=

affil-num=10
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School
kn-affil=
en-keyword=Medial meniscus
kn-keyword=Medial meniscus
en-keyword=Posterior root tear
kn-keyword=Posterior root tear
en-keyword=Osteoarthritis
kn-keyword=Osteoarthritis
en-keyword=Meniscal volume
kn-keyword=Meniscal volume
en-keyword=Medial extrusion
kn-keyword=Medial extrusion
en-keyword=Three-dimensional magnetic resonance imaging
kn-keyword=Three-dimensional magnetic resonance imaging
en-keyword=Flexed-knee position
kn-keyword=Flexed-knee position
END

start-ver=1.4
cd-journal=joma
no-vol=101-B
cd-vols=
no-issue=8
article-no=
start-page=1024
end-page=1031
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Preoperative surgical risk stratification in osteosarcoma based on the proximity to the major vessels
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aims</br>
The aim of this study was to determine the risk of local recurrence and survival in patients with osteosarcoma based on the proximity of the tumour to the major vessels.</br>
Patients and Methods</br>
A total of 226 patients with high-grade non-metastatic osteosarcoma in the limbs were investigated. Median age at diagnosis was 15 years (4 to 67) with the ratio of male to female patients being 1.5:1. The most common site of the tumour was the femur (n = 103) followed by tibia (n = 66). The vascular proximity was categorized based on the preoperative MRI after neoadjuvant chemotherapy into four types: type 1 > 5 mm; type 2 ? 5 mm, > 0 mm; type 3 attached; type 4 surrounded.</br>
Results</br>
Limb salvage rate based on the proximity type was 92%, 88%, 51%, and 0% for types 1 to 4, respectively, and the overall survival at five years was 82%, 77%, 57%, and 67%, respectively (p < 0.001). Local recurrence rate in patients with limb-salvage surgery was 7%, 8%, and 22% for the types 1 to 3, respectively (p = 0.041), and local recurrence at the perivascular area was observed in 1% and 4% for type 2 and 3, respectively. The mean microscopic margin to the major vessels was 6.9 mm, 3.0 mm, and 1.4 mm for types 1 to 3, respectively. In type 3, local recurrence-free survival with limb salvage was significantly poorer compared with amputation (p = 0.025), while the latter offered no overall survival benefit. In this group of patients, factors such as good response to chemotherapy or limited vascular attachment to less than half circumference or longitudinal 10 mm reduced the risk of local recurrence.</br>
Conclusion</br>
The proximity of osteosarcoma to major blood vessels is a poor prognostic factor for local control and survival. Amputation offers better local control for tumours attached to the blood vessels but does not improve survival. Limb salvage surgery offers similar local control if the tumour attachment to blood vessels is limited.
en-copyright=
kn-copyright=

en-aut-name=FujiwaraT.
en-aut-sei=Fujiwara
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MedellinM. R.
en-aut-sei=Medellin
en-aut-mei=M. R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Sambri A.
en-aut-sei=Sambri 
en-aut-mei=A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsudaY.
en-aut-sei=Tsuda
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=BalkoJ.
en-aut-sei=Balko
en-aut-mei=J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SumathiV.
en-aut-sei=Sumathi
en-aut-mei=V.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=GregoryJ.
en-aut-sei=Gregory
en-aut-mei=J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=JeysL.
en-aut-sei=Jeys
en-aut-mei=L.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=AbuduA.
en-aut-sei=Abudu
en-aut-mei=A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Oncology, The Royal Orthopaedic Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Oncology, The Royal Orthopaedic Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Oncology, The Royal Orthopaedic Hospital
kn-affil=

affil-num=5
en-affil=Department of Musculoskeletal Pathology, The Royal Orthopaedic Hospital
kn-affil=

affil-num=6
en-affil=Department of Musculoskeletal Pathology, The Royal Orthopaedic Hospital
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Oncology, The Royal Orthopaedic Hospital
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Oncology, The Royal Orthopaedic Hospital
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Oncology, The Royal Orthopaedic Hospital
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=44
cd-vols=
no-issue=2
article-no=
start-page=381
end-page=389
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Sacral chordoma: do the width of surgical margin and the use of photon/proton radiotherapy affect local disease control?
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose</br>
Chordoma is a rare but highly aggressive primary bone sarcoma that arises commonly from the sacrum. While en bloc resection has been the mainstay of the treatment, the role of resection margin in millimetres with/without adjuvant radiotherapy (RT) has been unknown. We investigated the prognostic impact of surgical margin width, adjuvant RT, and their combined factor for sacral chordoma.</br>
Methods</br>
Forty-eight patients who underwent surgical treatment between 1996 and 2016 were studied. Of these, 11 patients (23%) received adjuvant RT; photon RT in 7 (15%) and proton RT in 4 (8%). Margins were microscopically measured in millimetres from the resection surface to the closest tumour on histologic slides.</br>
Results</br>
The five year and ten year disease-specific survival was 88% and 58%, respectively, and the local recurrence (LR) rate was 48%. The LR rate with 0-mm, <?1.5-mm, and ??1.5-mm margin was 50% (group 1), 50% (group 2: RT?, 61%; group 3: RT+, 14%), and 0% (group 4), respectively. We observed a significantly lower LR rate in patients with adjuvant photon/proton RT (18%) than without it (57%; p?=?0.026), and no LR was observed after post-operative proton RT. The combined factor of margin with RT clearly stratified the LR risk: patients of group 1 (positive margin) and 2 (<?1.5-mm margin, RT?) had approximately 7.5× LR risk (p?=?0.049) compared with those of group 3 (<?1.5-mm margin, RT+) and 4 (??1.5-mm margin).</br>
Conclusion</br>
This study identified the lowest risk of local failure in tumour resection with ??1.5-mm margin or negative but <?1.5-mm margin with the use of adjuvant photon/proton radiotherapy for sacral chordoma. Early results of adjuvant proton RT demonstrated excellent local control.
en-copyright=
kn-copyright=

en-aut-name=FujiwaraTomohiro
en-aut-sei=Fujiwara
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TsudaYusuke
en-aut-sei=Tsuda
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=StevensonJonathan
en-aut-sei=Stevenson
en-aut-mei=Jonathan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ParryMichael
en-aut-sei=Parry
en-aut-mei=Michael
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=JeysLee
en-aut-sei=Jeys
en-aut-mei=Lee
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=

affil-num=3
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=

affil-num=4
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=

affil-num=5
en-affil=Oncology Service, The Royal Orthopaedic Hospital NHS Foundation Trust
kn-affil=
en-keyword=Chordoma
kn-keyword=Chordoma
en-keyword=Sacrum
kn-keyword=Sacrum
en-keyword=Surgery
kn-keyword=Surgery
en-keyword=Margin width
kn-keyword=Margin width
en-keyword=Radiotherapy
kn-keyword=Radiotherapy
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=82
end-page=91
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Region of Interest Growing Neural Gas for Real-Time Point Cloud Processing
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper proposes a real-time topological structure learning method based on concentrated/distributed sensing for a 2D/3D point cloud. First of all, we explain a modified Growing Neural Gas with Utility (GNG-U2) that can learn the topological structure of 3D space environment and color information simultaneously by using a weight vector. Next, we propose a Region Of Interest Growing Neural Gas (ROI-GNG) for realizing concentrated/distributed sensing in real-time. In ROI-GNG, the discount rates of the accumulated error and utility value are variable according to the situation. We show experimental results of the proposed method and discuss the effectiveness of the proposed method.
en-copyright=
kn-copyright=

en-aut-name=TodaYuichiro
en-aut-sei=Toda
en-aut-mei=Yuichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=LiXiang
en-aut-sei=Li
en-aut-mei=Xiang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsunoTakayuki
en-aut-sei=Matsuno
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MinamiMamoru
en-aut-sei=Minami
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=

affil-num=2
en-affil=Okayama University
kn-affil=

affil-num=3
en-affil=Okayama University
kn-affil=

affil-num=4
en-affil=Okayama University
kn-affil=
en-keyword=Growing Neural Gas
kn-keyword=Growing Neural Gas
en-keyword=Point cloud processing
kn-keyword=Point cloud processing
en-keyword=Topological structure learning
kn-keyword=Topological structure learning
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=11
article-no=
start-page=3416
end-page=3425
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191128
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Transtibial fixation for medial meniscus posterior root tear reduces posterior extrusion and physiological translation of the medial meniscus in middle-aged and elderly patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose</br>
To investigate changes in meniscal extrusion during knee flexion before and after pullout fixation for medial meniscus posterior root tear (MMPRT) and determine whether these changes correlate with articular cartilage degeneration and short-term clinical outcomes.</br>
Methods</br>
Twenty-two patients (mean age 58.4?±?8.2 years) diagnosed with type II MMPRT underwent open magnetic resonance imaging preoperatively, 3 months after transtibial fixation and at 12 months after surgery, when second-look arthroscopy was also performed. The medial meniscus medial extrusion (MMME) and the medial meniscus posterior extrusion (MMPE) were measured at knee 10° and 90° flexion at which medial meniscus (MM) posterior translation was also calculated. Articular cartilage degeneration was assessed using International Cartilage Research Society grade at primary surgery and second-look arthroscopy. Clinical evaluations included Knee Injury and Osteoarthritis Outcome Score, International Knee Documentation Committee subjective knee evaluation form, Lysholm score, Tegner activity level scale, and pain visual analogue scale.</br>
Results</br>
MMPE at 10° knee flexion was higher 12 months postoperatively than preoperatively (4.8?±?1.5 vs. 3.5?±?1.2, p?=?0.01). MMPE at 90° knee flexion and MM posterior translation were smaller 12 months postoperatively than preoperatively (3.5?±?1.1 vs. 4.6?±?1.3, 7.2?±?1.7 vs. 8.9?±?2.0, p?<?0.01). Articular cartilage degeneration of medial femoral condyle correlated with MMME in knee extension (r?=?0.5, p?=?0.04). All clinical scores significantly improved 12 months postoperatively. However, correlations of all clinical scores against decreased MMPE and increased MMME were not detected.</br>
Conclusions</br>
MMPRT transtibial fixation suppressed the progression of MMPE and cartilage degeneration and progressed MMME minimally in knee flexion position at 1 year. However, in the knee extension position, MMME progressed and correlated with cartilage degeneration of medial femoral condyle. MMPRT transtibial fixation contributes to the dynamic stability of the MM in the knee flexion position.
en-copyright=
kn-copyright=

en-aut-name=KodamaYuya
en-aut-sei=Kodama
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurumatsuTakayuki
en-aut-sei=Furumatsu
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MasudaShin
en-aut-sei=Masuda
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkazakiYoshiki
en-aut-sei=Okazaki
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamatsukiYusuke
en-aut-sei=Kamatsuki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkazakiYuki
en-aut-sei=Okazaki
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HiranakaTakaaki
en-aut-sei=Hiranaka
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MiyazawaShinichi
en-aut-sei=Miyazawa
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YasumitsuMasaharu
en-aut-sei=Yasumitsu
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Orthopaedic Surgery, Iwakuni Clinical Center
kn-affil=

affil-num=10
en-affil=Department of Orthopaedic Surgery, Okayama University Hospital
kn-affil=
en-keyword=Medial meniscus
kn-keyword=Medial meniscus
en-keyword=Posterior root tear
kn-keyword=Posterior root tear
en-keyword=Transtibial fixation
kn-keyword=Transtibial fixation
en-keyword=Meniscus extrusion
kn-keyword=Meniscus extrusion
en-keyword=Open magnetic resonance imaging
kn-keyword=Open magnetic resonance imaging
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=3
article-no=
start-page=119
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cerebral circulation improves with indirect bypass surgery combined with gene therapy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Angiogenesis involves new blood vessels sprouting from preexisting blood vessels. This process may serve to improve brain circulation. Moyamoya disease (MMD) is a cerebrovascular disorder causing intracranial stenosis which significantly reduces the blood supply to the brain. Mainly stroke is the first symptom of the disorder, so treatments that reduce the risk of stroke are used for patients with MMD. To prevent stroke for those with chronic cerebral hypoperfusion, more blood needs to flow to the brain, which was thought to be achieved by enhancing angiogenesis. Indirect bypass surgery, such as encephalo-myo-synangiosis (EMS), is used for revascularization. However, EMS alone sometimes cannot provide enough circulation to avoid ischemic strokes. The current study examined if EMS combined with high-mobility group box-1 (HMGB1) and vascular endothelial growth factor (VEGF) enhanced angiogenesis and increased cerebral circulation. The results indicated that HMGB1 administered with EMS increased angiogenesis through a VEGF-dependent mechanism. In addition, exercising and stem cell transplantation possess possible means to increase angiogenesis. Overall, EMS with gene therapy, maintaining fitness, and stem cell utilization may prevent or help one recover from stroke by enhancing brain angiogenesis. Thus, these treatments may be applicable for patients with MMD. This paper is a review article. Referred literature in this paper has been listed in the references section. The datasets supporting the conclusions of this article are available online by searching various databases, including PubMed.
en-copyright=
kn-copyright=

en-aut-name=ShearAlex
en-aut-sei=Shear
en-aut-mei=Alex
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishihiroShingo
en-aut-sei=Nishihiro
en-aut-mei=Shingo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HishikawaTomohito
en-aut-sei=Hishikawa
en-aut-mei=Tomohito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HiramatsuMasafumi
en-aut-sei=Hiramatsu
en-aut-mei=Masafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SugiuKenji
en-aut-sei=Sugiu
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YasuharaTakao
en-aut-sei=Yasuhara
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani
kn-affil=

affil-num=2
en-affil=Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Neurological Surgery, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Angiogenesis
kn-keyword=Angiogenesis
en-keyword=cerebral hypoperfusion
kn-keyword=cerebral hypoperfusion
en-keyword=encephalo-myo-synangiosis
kn-keyword=encephalo-myo-synangiosis
en-keyword=endothelial progenitor cells
kn-keyword=endothelial progenitor cells
en-keyword=high-mobility group box-1
kn-keyword=high-mobility group box-1
en-keyword=revascularization
kn-keyword=revascularization
en-keyword=vascular endothelial growth factor
kn-keyword=vascular endothelial growth factor
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=6
article-no=
start-page=792
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201906
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=MZF1 and SCAND1 Reciprocally Regulate CDC37 Gene Expression in Prostate Cancer 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Cell division control 37 (CDC37) increases the stability of heat shock protein 90 (HSP90) client proteins and is thus essential for numerous intracellular oncogenic signaling pathways, playing a key role in prostate oncogenesis. Notably, elevated expression of CDC37 was found in prostate cancer cells, although the regulatory mechanisms through which CDC37 expression becomes increased are unknown. Here we show both positive and negative regulation of CDC37 gene transcription by two members of the SREZBP-CTfin51-AW1-Number 18 cDNA (SCAN) transcription factor family-MZF1 and SCAND1, respectively. Consensus DNA-binding motifs for myeloid zinc finger 1 (MZF1/ZSCAN6) were abundant in the CDC37 promoter region. MZF1 became bound to these regulatory sites and trans-activated the CDC37 gene whereas MZF1 depletion decreased CDC37 transcription and reduced the tumorigenesis of prostate cancer cells. On the other hand, SCAND1, a zinc fingerless SCAN box protein that potentially inhibits MZF1, accumulated at MZF1-binding sites in the CDC37 gene, negatively regulated the CDC37 gene and inhibited tumorigenesis. SCAND1 was abundantly expressed in normal prostate cells but was reduced in prostate cancer cells, suggesting a potential tumor suppressor role of SCAND1 in prostate cancer. These findings indicate that CDC37, a crucial protein in prostate cancer progression, is regulated reciprocally by MZF1 and SCAND1. 
en-copyright=
kn-copyright=

en-aut-name=EguchiTakanori
en-aut-sei=Eguchi
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=PrinceThomas L
en-aut-sei=Prince
en-aut-mei=Thomas L
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Manh Tien Tran
en-aut-sei=Manh Tien Tran
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SogawaChiharu
en-aut-sei=Sogawa
en-aut-mei=Chiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=LangBenjamin J
en-aut-sei=Lang
en-aut-mei=Benjamin J
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=CalderwoodStuart K
en-aut-sei=Calderwood
en-aut-mei=Stuart K
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=  Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
kn-affil=

affil-num=3
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=  Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
kn-affil=

affil-num=6
en-affil=  Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School
kn-affil=
en-keyword=CDC37
kn-keyword=CDC37
en-keyword=MZF1
kn-keyword=MZF1
en-keyword=SCAN zinc finger
kn-keyword=SCAN zinc finger
en-keyword=SCAND1
kn-keyword=SCAND1
en-keyword=prostate cancer
kn-keyword=prostate cancer
END

start-ver=1.4
cd-journal=joma
no-vol=240
cd-vols=
no-issue=3
article-no=
start-page=032001
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Numerical study of air-entraining and submerged vortices in a pump sump
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Numerical detection of harmful vortices in pump sumps, such as an air-entraining vortex (AEV) and a submerged vortex (SMV), is crucially important to develop the drain pump machinery. We performed numerical simulations of the benchmark experiments of the pump sump conducted by Matsui et al. (2006 and 2016) using the OpenFOAM and compared the simulation results with the experimental data considering the effects of turbulence model, grid density and detection method of the vortices. We studied the threshold of the gas-liquid volume fraction of the VOF method and the second invariant of velocity gradient tensor to identify AEV and SMV. The methods proposed in the present paper were found to be very effective for the detection of the vortices, and the simulation results by RANS with the SST k-omega model successfully reproduced the experimental data. LES with the Smagorinsky model, however, was sensitive to the grid system and difficult to reproduce the experimental data even for the finest grid system having 3.7 million cells in the present study.
en-copyright=
kn-copyright=

en-aut-name=YanaseShinichiro
en-aut-sei=Yanase
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamasakiRyo
en-aut-sei=Yamasaki
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KouchiToshinori
en-aut-sei=Kouchi
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HosodaShunsuke
en-aut-sei=Hosoda
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NagataYasunori
en-aut-sei=Nagata
en-aut-mei=Yasunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShunjiHiguchi
en-aut-sei=Shunji
en-aut-mei=Higuchi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawabeToshihiko
en-aut-sei=Kawabe
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakamiToshihiro
en-aut-sei=Takami
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=

affil-num=2
en-affil=Technical Division, Tsurumi Manufacturing Co.
kn-affil=

affil-num=3
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Mechanical and Systems Engineering, Okayama University
kn-affil=

affil-num=6
en-affil=Technical Division, Tsurumi Manufacturing Co.
kn-affil=

affil-num=7
en-affil=Technical Division, Tsurumi Manufacturing Co.
kn-affil=

affil-num=8
en-affil=Department of Mechanical and Systems Engineering, Okayama University of Science
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=101
cd-vols=
no-issue=
article-no=
start-page=46
end-page=63
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of an Intercultural Education Program to Support Japanese Students Returning from Study Abroad: A Trial Implementation of Self-help Group Activities for Care and Career Enhancement of Returnee Students
kn-title=海外留学から帰国した日本人学生を対象とする帰国後異文化間教育プログラムの開発-帰国後のケアとキャリア形成を目的とした自助グループ活動実践の試み-
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TakahamaAi
en-aut-sei=Takahama
en-aut-mei=Ai
kn-aut-name=���M愛
kn-aut-sei=���M
kn-aut-mei=愛
aut-affil-num=1
ORCID=

en-aut-name=TanakaTomoko
en-aut-sei=Tanaka
en-aut-mei=Tomoko
kn-aut-name=田中共子
kn-aut-sei=田中
kn-aut-mei=共子
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Project Researcher, Interfaculty Initiative in Information Studies, The University of Tokyo
kn-affil=東京大学大学院情報学環

affil-num=2
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
en-keyword=帰国後教育
kn-keyword=帰国後教育
en-keyword=カルチャーショック
kn-keyword=カルチャーショック
END

start-ver=1.4
cd-journal=joma
no-vol=100
cd-vols=
no-issue=
article-no=
start-page=32
end-page=43
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201907
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=For Interaction with Muslim International Students: From View Point of Japanese Commonality on Case and Practical Studies
kn-title=ムスリム留学生との交流のために−調査・実践から見えてきた日本的共同性の視点−
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakanoSachiko
en-aut-sei=Nakano
en-aut-mei=Sachiko
kn-aut-name=中野祥子
kn-aut-sei=中野
kn-aut-mei=祥子
aut-affil-num=1
ORCID=

en-aut-name=TanakaTomoko
en-aut-sei=Tanaka
en-aut-mei=Tomoko
kn-aut-name=田中共子
kn-aut-sei=田中
kn-aut-mei=共子
aut-affil-num=2
ORCID=

affil-num=1
en-affil=International Students Center, Yamaguchi University
kn-affil=山口大学大学教育機構留学生センター

affil-num=2
en-affil=Graduate School of Humanities and Social Science, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
en-keyword=在日ムスリム留学生
kn-keyword=在日ムスリム留学生
en-keyword=異文化交流
kn-keyword=異文化交流
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=1
article-no=
start-page=29
end-page=40
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190626
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Mechanism Linking Discrimination, Conflict, and Switching Behaviour in Bicultural Individuals
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study focuses on the switching behaviour exhibited by Zainichi Koreans (ethnic Koreans living in Japan who have effectively managed to maintain their Korean nationality and have
 been granted the status of tokubetsu eijusha [“special” permanent residents] by the Japanese government). In the present article, the term “switching” refers to the alteration of behaviour according to different cultural contexts. This study aimed to identify the mechanism underlying links between perceived discrimination, internal conflict, and switching. A questionnaire survey was conducted with 184 Zainichi Koreans. Path analyses showed that discrimination had a significant effect on conflict (β = .31, p < .001), and that conflict enhanced switching significantly (β = .25, p < .001). In addition, discrimination directly exerted a significant, positive effect on switching (β = .25, p < .001). These findings suggest that switching may ultimately be caused by discrimination on the part of the host’s majority society or individuals. This study’s findings contribute to the theory that switching is a way for immigrants to protect themselves if they perceive discrimination from ? or feel conflicted toward ? the society in which they live.
en-copyright=
kn-copyright=

en-aut-name=TanakaTomoko
en-aut-sei=Tanaka
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=LeeJungHui
en-aut-sei=Lee
en-aut-mei=JungHui
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Okayama University
kn-affil=

affil-num=2
en-affil=Kanagawa Dental University
kn-affil=
en-keyword=bicultural individuals
kn-keyword=bicultural individuals
en-keyword=conflict
kn-keyword=conflict
en-keyword=discrimination
kn-keyword=discrimination
en-keyword=Japan
kn-keyword=Japan
en-keyword=switching
kn-keyword=switching
en-keyword=Zainichi Koreans
kn-keyword=Zainichi Koreans
END

start-ver=1.4
cd-journal=joma
no-vol=2
cd-vols=
no-issue=3
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190603
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Solid-state nuclear magnetic resonance study of setting mechanism of beta-tricalcium phosphate-inositol phosphate composite cements
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Solid-state nuclear magnetic resonance (NMR) spectroscopy is a technique, which can be used to provide insight into the chemical structure of non-crystalline and crystalline materials. Hence, the present study aimed to elucidate the setting mechanism of CPC, which was fabricated using beta -tricalcium phosphate (beta -TCP)-inositol phosphate (IP6) composite powder using NMR In addition, the effect of IP6 on the local chemical structure of the beta -TCP-IP6 composite powder and its hardened cement would also be investigated. The H-1 -> P-31 heteronuclear correlation NMR spectrum revealed that an amorphous hydrated layer, along with small amount of hydroxyapatite (HA) was formed on the surface of beta -TCP during the ball-milling process. Results demonstrated that the IP6 in the hydrated layer on the surface of beta -TCP inhibited the formation of HA. Moreover, the setting reaction of the cement was mainly triggered by the dissolution of the amorphous hydrated layer on beta -TCP surface, and subsequent precipitation, followed by the inter-entanglement between the HA crystals on the beta -TCP.
en-copyright=
kn-copyright=

en-aut-name=KonishiToshiisa
en-aut-sei=Konishi
en-aut-mei=Toshiisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamashitaKohei
en-aut-sei=Yamashita
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NagataKohei
en-aut-sei=Nagata
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=LimPoon Nian
en-aut-sei=Lim
en-aut-mei=Poon Nian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ThianEng San
en-aut-sei=Thian
en-aut-mei=Eng San
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AizawaMamoru
en-aut-sei=Aizawa
en-aut-mei=Mamoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Organization for the Strategic Coordination of Research and Intellectual Property, Meiji University
kn-affil=

affil-num=4
en-affil=Department of Mechanical Engineering, National University of Singapore
kn-affil=

affil-num=5
en-affil=Department of Mechanical Engineering, National University of Singapore
kn-affil=

affil-num=6
en-affil=Department of Applied Chemistry, School of Science and Technology, Meiji University
kn-affil=
en-keyword=beta-tricalcium phosphate
kn-keyword=beta-tricalcium phosphate
en-keyword=calcium-phosphate cement
kn-keyword=calcium-phosphate cement
en-keyword=inositol phosphate
kn-keyword=inositol phosphate
en-keyword=solid-state NMR
kn-keyword=solid-state NMR
en-keyword=setting mechanism
kn-keyword=setting mechanism
END

start-ver=1.4
cd-journal=joma
no-vol=220
cd-vols=
no-issue=9
article-no=
start-page=1900021
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190403
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Rapid Synthesis of Poly(methyl methacrylate) Particles with High Molecular Weight by Soap‐Free Emulsion Polymerization Using Water‐in‐Oil Slug Flow
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= flow process for the production of poly(methyl methacrylate) (PMMA) particles is proposed by soap‐free emulsion polymerization using a water‐in‐oil (W/O) slug flow in a microreactor. Thin oil films generated around the dispersed aqueous phase of the W/O slug prevent the prepared particles from adhesion to the microchannel wall, enabling the continuous production of PMMA particles without clogging. The effects of the linear flow rate of the slug flow and the addition of ethanol in the dispersed aqueous phase on the polymerization are evaluated. It is found that increasing the linear flow rate of the slug flow or the addition of ethanol in the dispersed aqueous phase results in PMMA particles with high molecular weight (?1500 kg mol?1) in 20 min reaction time. It is believed that this process would be a promising way to prepare polymer particles with high molecular weight in a short reaction time.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KaritaKengo
en-aut-sei=Karita
en-aut-mei=Kengo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TawaraKoki
en-aut-sei=Tawara
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SogaTakuya
en-aut-sei=Soga
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=heterogeneous polymerization
kn-keyword=heterogeneous polymerization
en-keyword=internal circulation
kn-keyword=internal circulation
en-keyword=microreactors
kn-keyword=microreactors
en-keyword=microspheres
kn-keyword=microspheres
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=6
article-no=
start-page=2358
end-page=2367
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Microfluidic Formation of Hydrogel Microcapsules with a Single Aqueous Core by
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report a simple process to fabricate monodisperse tetra-arm poly(ethylene glycol) (tetra-PEG) hydrogel microcapsules with an aqueous core and a semipermeable hydrogel shell through the formation of aqueous two-phase system (ATPS) droplets consisting of a dextran-rich core and a tetra-PEG macromonomer-rich shell, followed by a spontaneous cross-end coupling reaction of tetra-PEG macromonomers in the shell. Different from conventional techniques, this process enables for the continuous production of hydrogel microcapsules from water-in-oil emulsion droplets under mild conditions in the absence of radical initiators and external stimuli such as heating and ultraviolet light irradiation. We find that rapid cross-end coupling reaction of tetra-PEG macromonomers in ATPS droplets in the range of pH from 7.4 to 7.8 gives hydrogel microcapsules with a kinetically arrested core?shell structure. The diameter and core?shell ratio of the microcapsules can be easily controlled by adjusting flow rates and ATPS compositions. On the other hand, the slow cross-end coupling reaction of tetra-PEG macromonomers in ATPS droplets at pH 7.0 and lower induces structural change from core?shell to Janus during the reaction, which eventually forms hydrogel microparticles with a thermodynamically stable crescent structure. We believe that these hydrogel microparticles with controlled structures can be used in biomedical fields such as cell encapsulation, biosensors, and drug delivery carriers for sensitive biomolecules.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MotohiroIbuki
en-aut-sei=Motohiro
en-aut-mei=Ibuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Division of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=6
article-no=
start-page=1572
end-page=1581
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191223
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Preparation of tough, thermally stable, and water-resistant double-network ion gels consisting of silica nanoparticles/poly(ionic liquid)s through photopolymerisation of an ionic monomer and subsequent solvent removal
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We report the preparation of tough, thermally stable, and water-resistant double-network (DN) ion gels, which consist of a partially-clustered silica nanoparticle network and poly(ionic liquid) (PIL) network holding an ionic liquid. Silica nanoparticles/poly([Evim][Tf2N]) DN ion gels are prepared by photo-induced radical polymerisation of [Evim][Tf2N] in a mixture containing silica nanoparticles, [Bmim][Tf2N], ionic liquid based cross-linker [(VIM)2C4][Tf2N]2, and ethyl acetate, followed by subsequent solvent evaporation. Tensile strength measurements show that the mechanical properties of the PIL DN ion gels were higher than those of the PIL single-network (SN) ion gel. A rheological study indicates that an enhancement in mechanical strength of the PIL DN ion gels can be achieved when silica nanoparticles form partial clusters in [Bmim][Tf2N]. The cyclic stress?strain measurement of the PIL DN ion gels shows hysteresis loops, suggesting that the silica nanoparticle clusters rupture and dissipate the loading energy when the PIL DN ion gels undergo a large deformation. The fracture strength and Young's modulus of the PIL DN ion gels increase as the diameter of the silica nanoparticles is decreased. Thermogravimetric analysis measurement shows that the PIL DN ion gel has a high decomposition temperature of approximately 400 °C. Moreover, the swelling test shows that the PIL DN ion gel possesses an excellent water-resistant property because of the hydrophobic nature of the PIL backbone. We believe that such tough, thermally stable, and water-resistant PIL DN ion gels can be used as carbon dioxide separation membranes, sensors, and actuators for soft robotics.
en-copyright=
kn-copyright=

en-aut-name=WatanabeTakaichi
en-aut-sei=Watanabe
en-aut-mei=Takaichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakahashiRuri
en-aut-sei=Takahashi
en-aut-mei=Ruri
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OnoTsutomu
en-aut-sei=Ono
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Applied Chemistry, Graduate School of Natural Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=6
article-no=
start-page=1792
end-page=1800
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Decrosslinking enables visualization of RNA-guided endonuclease-in situ labeling signals for DNA sequences in plant tissues
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Information about the positioning of individual loci in the nucleus and the status of epigenetic modifications at these loci in each cell contained in plant tissue increases our understanding of how cells in a tissue coordinate gene expression. To obtain such information, a less damaging method of visualizing DNA in tissue that can be used with immunohistochemistry is required. Recently, a less damaging DNA visualization method using the CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/associated caspase 9) system, named RNA-guided endonuclease-in situ labeling (RGEN-ISL), was reported. This system made it possible to visualize a target DNA locus in a nucleus fixed on a glass slide with a set of simple operations, but it could not be applied to cells in plant tissues. In this work, we have developed a modified RGEN-ISL method with decrosslinking that made it possible to simultaneously detect the DNA loci and immunohistochemistry signals, including histone modification, in various types of plant tissues and species.	
en-copyright=
kn-copyright=

en-aut-name=NagakiK.
en-aut-sei=Nagaki
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamajiN.
en-aut-sei=Yamaji
en-aut-mei=N.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Centromere
kn-keyword=Centromere
en-keyword=CRISPR/Cas9
kn-keyword=CRISPR/Cas9
en-keyword=epigenetic modifications
kn-keyword=epigenetic modifications
en-keyword=immunohistochemistry
kn-keyword=immunohistochemistry
en-keyword=in situ DNA visualization
kn-keyword=in situ DNA visualization
en-keyword=RNA-guided endonuclease-in situ labeling (RGEN-ISL)
kn-keyword=RNA-guided endonuclease-in situ labeling (RGEN-ISL)
en-keyword=telomere
kn-keyword=telomere
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=47
article-no=
start-page=66
end-page=57
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=日本語語彙学習の実践的研究―単語カード使用による効果の検証―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=林美秀
kn-aut-sei=林
kn-aut-mei=美秀
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=台湾嶺東科技大学
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=47
article-no=
start-page=56
end-page=47
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=「支払いの金銭」を表す漢語接尾辞について―「-賃」「-代」「-料」「-費」「-金」の用法―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=姜暁偉
kn-aut-sei=姜
kn-aut-mei=暁偉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=萩原工業
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=47
article-no=
start-page=46
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=逆接仮定を表す接続助詞トモと卜をめぐって
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=江原由美子
kn-aut-sei=江原
kn-aut-mei=由美子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=津山工業高等専門学校
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=47
article-no=
start-page=16
end-page=35
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=倉敷市蔵薄田泣菫文庫　薄田泣菫日記(大正七年一月)翻刻・解説
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=西山康一
kn-aut-sei=西山
kn-aut-mei=康一
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=荒井真理亜
kn-aut-sei=荒井
kn-aut-mei=真理亜
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科

affil-num=2
en-affil=
kn-affil=相愛大学人文学部
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=47
article-no=
start-page=1
end-page=15
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190331
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=人麻呂の泣血哀慟歌と虫麻呂の〈畿内伝説歌〉
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=錦織浩文
kn-aut-sei=錦織
kn-aut-mei=浩文
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=阿南工業高等専門学校
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=5
article-no=
start-page=1918
end-page=1927
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191025
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Tactile angle discriminability improvement: roles of training time intervals and different types of training tasks
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Perceptual learning, which is not limited to sensory modalities such as vision and touch, emerges within a training session and between training sessions and is accompanied by the remodeling of neural connections in the cortex. However, limited knowledge exists regarding perceptual learning between training sessions. Although tactile studies have paid attention to between-session learning effects, there have been few studies asking fundamental questions regarding whether the time interval between training sessions affects tactile perceptual learning and generalization across tactile tasks. We investigated the effects of different training time intervals on the consecutive performance of a tactile angle discrimination (AD) task and a tactile orientation discrimination (OD) task training on tactile angle discriminability. The results indicated that in the short-interval training group, AD task performance significantly improved in the early stage of learning and nearly plateaued in the later stage, whereas in the long-interval training group, significant improvement was delayed and then also nearly plateaued in the later stage; additionally, improved OD task performance resulted in improved AD task performance. These findings suggest that training time interval affects the early stage of learning but not the later stage and that generalization occurs between different types of tactile tasks.
en-copyright=
kn-copyright=

en-aut-name=WangWu
en-aut-sei=Wang
en-aut-mei=Wu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YangJiajia
en-aut-sei=Yang
en-aut-mei=Jiajia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WuQiong
en-aut-sei=Wu
en-aut-mei=Qiong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YuJiabin
en-aut-sei=Yu
en-aut-mei=Jiabin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakahashiSatoshi
en-aut-sei=Takahashi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=EjimaYoshimichi
en-aut-sei=Ejima
en-aut-mei=Yoshimichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=WuJinglong
en-aut-sei=Wu
en-aut-mei=Jinglong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil= Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=between-session learning
kn-keyword=between-session learning
en-keyword=generalization
kn-keyword=generalization
en-keyword=tactile angle discriminability
kn-keyword=tactile angle discriminability
en-keyword=training time interval
kn-keyword=training time interval
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=10
article-no=
start-page=2717
end-page=2725
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190506
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The tonoplast-localized transporter OsHMA3 plays an important role in maintaining Zn homeostasis in rice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In order to respond to fluctuating zinc (Zn) in the environment, plants must have a system to control Zn homeostasis. However, how plants maintain an appropriate level of Zn during their growth and development is still poorly understood. In this study, we found that OsHMA3, a tonoplast-localized transporter for Zn/Cd, plays an important role in Zn homeostasis in rice. Accessions with the functional allele of OsHMA3 showed greater tolerance to high Zn than those with the non-functional allele based on root elongation test. A 67Zn-labeling experiment showed that accessions with loss of function of OsHMA3 had lower Zn accumulation in the roots but similar concentrations in the shoots compared with functional OsHMA3 accessions. When exposed to Zn-free growing medium, the concentration in the root cell sap was rapidly decreased in accessions with functional OsHMA3, but less dramatic changes were observed in non-functional accessions. A mobility experiment showed that more Zn in the roots was translocated to the shoots in accessions with functional OsHMA3. Higher expression levels of OsZIP4, OsZIP5, OsZIP8, and OsZIP10 were found in the roots of accessions with functional OsHMA3 in response to Zn deficiency. Taken together, our results indicate that OsHMA3 plays an important role in rice roots in both Zn detoxification and storage by sequestration into the vacuoles, depending on Zn concentration in the environment.
en-copyright=
kn-copyright=

en-aut-name=CaiHongmei
en-aut-sei=Cai
en-aut-mei=Hongmei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HuangSheng
en-aut-sei=Huang
en-aut-mei=Sheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=CheJing
en-aut-sei=Che
en-aut-mei=Jing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamajiNaoki
en-aut-sei=Yamaji
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MaJian Feng
en-aut-sei=Ma
en-aut-mei=Jian Feng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=OsHMA3
kn-keyword=OsHMA3
en-keyword=vacuolar sequestration
kn-keyword=vacuolar sequestration
en-keyword=ZIP transporter
kn-keyword=ZIP transporter
en-keyword=Zn distribution
kn-keyword=Zn distribution
en-keyword= Zn root-to-shoot mobility
kn-keyword= Zn root-to-shoot mobility
en-keyword=Zn tolerance
kn-keyword=Zn tolerance
END

start-ver=1.4
cd-journal=joma
no-vol=70
cd-vols=
no-issue=5
article-no=
start-page=1683
end-page=1696
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190502
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Honeydew-associated microbes elicit defense responses against brown planthopper in rice
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Feeding of sucking insects, such as the rice brown planthopper (Nilaparvata lugens; BPH), causes only limited mechanical damage on plants that is otherwise essential for injury-triggered defense responses against herbivores. In pursuit of complementary BPH elicitors perceived by plants, we examined the potential effects of BPH honeydew secretions on the BPH monocot host, rice (Oryza sativa). We found that BPH honeydew strongly elicits direct and putative indirect defenses in rice, namely accumulation of phytoalexins in the leaves, and release of volatile organic compounds from the leaves that serve to attract natural enemies of herbivores, respectively. We then examined the elicitor active components in the honeydew and found that bacteria in the secretions are responsible for the activation of plant defense. Corroborating the importance of honeydew-associated microbiota for induced plant resistance, BPHs partially devoid of their microbiota via prolonged antibiotics ingestion induced significantly less defense in rice relative to antibiotic-free insects applied to similar groups of plants. Our data suggest that rice plants may additionally perceive herbivores via their honeydew-associated microbes, allowing them to discriminate between incompatible herbivores?that do not produce honeydew?and those that are compatible and therefore dangerous.
en-copyright=
kn-copyright=

en-aut-name=WariDavid
en-aut-sei=Wari
en-aut-mei=David
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KabirMd Alamgir
en-aut-sei=Kabir
en-aut-mei=Md Alamgir
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MujionoKadis
en-aut-sei=Mujiono
en-aut-mei=Kadis
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HojoYuko
en-aut-sei=Hojo
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShinyaTomonori
en-aut-sei=Shinya
en-aut-mei=Tomonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TaniAkio
en-aut-sei=Tani
en-aut-mei=Akio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakataniHiroko
en-aut-sei=Nakatani
en-aut-mei=Hiroko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=GalisIvan
en-aut-sei=Galis
en-aut-mei=Ivan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=4
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=5
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=6
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=7
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=8
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=Honeydew-associated microorganisms
kn-keyword=Honeydew-associated microorganisms
en-keyword=phytoalexins
kn-keyword=phytoalexins
en-keyword=plant defense
kn-keyword=plant defense
en-keyword=rice (Oryza sativa)
kn-keyword=rice (Oryza sativa)
en-keyword=rice brown planthopper (Nilaparvata lugens)
kn-keyword=rice brown planthopper (Nilaparvata lugens)
en-keyword=sucking insect
kn-keyword=sucking insect
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=2
article-no=
start-page=137
end-page=149
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191023
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A proposal of calligraphy learning assistant system with letter portion practice function using projection mapping
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose</br>
For several decades, calligraphy has been popular among people in Japan, China, and even in the world. Traditionally, a teacher teaches how to write letters on a paper with a brush, and a student will imitate them by referring to the model letters. However, if a teacher is not available, this method will not be applicable either. This study aims to propose a calligraphy learning assistant system (CLAS) using projection mapping, which allows a student to learn calligraphy by him/herself.</br>
Design/methodology/approach</br>
By following the letter writing video of a teacher that is directly projected on the paper, a student is able to learn the stroke order and writing speed in addition to the letter shape. Moreover, the letter portion practice function is incorporated in CLAS to allow a learner to repeat practicing hard portions of each letter.</br>
Findings</br>
For evaluations, the authors implemented CLAS using Raspberry Pi and open-source software and asked students to use it. The results confirmed that CLAS is effective in improving calligraphy skills of novice students.</br>
Originality/value</br>
With CLAS, a student can practice calligraphy using a conventional brush, ink and paper at a desk while looking at the model letter writing of a teacher projected on the paper using projection mapping.
en-copyright=
kn-copyright=

en-aut-name=HudaSamsul
en-aut-sei=Huda
en-aut-mei=Samsul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FunabikiNobuo
en-aut-sei=Funabiki
en-aut-mei=Nobuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KuribayashiMinoru
en-aut-sei=Kuribayashi
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KaoWen-Chung 
en-aut-sei=Kao
en-aut-mei=Wen-Chung 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Electrical Engineering, National Taiwan Normal University
kn-affil=
en-keyword=Raspberry Pi
kn-keyword=Raspberry Pi
en-keyword=Calligraphy
kn-keyword=Calligraphy
en-keyword=Learning assistant system
kn-keyword=Learning assistant system
en-keyword=Projection mapping
kn-keyword=Projection mapping
END

start-ver=1.4
cd-journal=joma
no-vol=6
cd-vols=
no-issue=4
article-no=
start-page=330
end-page=339
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Higher enhanced computed tomography attenuation value of the aorta is a predictor of massive transfusion in blunt trauma patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective</br>
Several scoring systems have been developed to identify patients who require massive transfusion (MT) after major trauma to improve survival. The primary goal of this study was to investigate the usefulness of enhanced computed tomography attenuation values (CTAVs) of major vessels to determine the need for MT in patients with major blunt trauma.</br>
Methods</br>
This single-center retrospective cohort study evaluated patients aged 16 years or older who underwent contrast-enhanced computed tomography scan of the torso after major blunt trauma. The CTAVs of six major vessel points in both the arterial and portal venous phases at initial computed tomography examination were assessed and compared between the MT and the no MT group. The capability of enhanced CTAVs to predict the necessity for MT was estimated based on the area under the receiver operating characteristic curve.</br>
Results</br>
Of the 254 eligible patients, 36 (14%) were in the MT group. Patients in the MT group had significantly higher CTAVs at all sites except the inferior vena cava in both the arterial and portal venous phases than that in the no MT group. The descending aorta in the arterial phase had the highest accuracy for predicting MT, with an AUROC of 0.901 (95% confidence interval, 0.855 to 0.947; P<0.001).</br>
Conclusion</br>
Initial elevation of enhanced CTAV of the aorta is a predictor for the need for MT. A higher CTAV of the aorta should alert the trauma surgeon or emergency physician to activate their MT protocol.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=YumotoTetsuya
kn-aut-sei=Yumoto
kn-aut-mei=Tetsuya
aut-affil-num=1
ORCID=

en-aut-name=IhoriyaHiromi
en-aut-sei=Ihoriya
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanabeRyo
en-aut-sei=Tanabe
en-aut-mei=Ryo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NaitouHiromichi
en-aut-sei=Naitou
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Computed tomography attenuated value
kn-keyword=Computed tomography attenuated value
en-keyword=Massive transfusion
kn-keyword=Massive transfusion
en-keyword=Wounds and injuries
kn-keyword=Wounds and injuries
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=10
article-no=
start-page=e0223656
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191017
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Identification of social relation within pedestrian dyads
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study focuses on social pedestrian groups in public spaces and makes an effort to identify the type of social relation between the group members. As a first step for this identification problem, we focus on dyads (i.e. 2 people groups). Moreover, as a mutually exclusive categorization of social relations, we consider the domain-based approach of Bugental, which precisely corresponds to social relations of colleagues, couples, friends and families, and identify each dyad with one of those relations. For this purpose, we use anonymized trajectory data and derive a set of observables thereof, namely, inter-personal distance, group velocity, velocity difference and height difference. Subsequently, we use the probability density functions (pdf) of these observables as a tool to understand the nature of the relation between pedestrians. To that end, we propose different ways of using the pdfs. Namely, we introduce a probabilistic Bayesian approach and contrast it to a functional metric one and evaluate the performance of both methods with appropriate assessment measures. This study stands out as the first attempt to automatically recognize social relation between pedestrian groups. Additionally, in doing that it uses completely anonymous data and proves that social relation is still possible to recognize with a good accuracy without invading privacy. In particular, our findings indicate that significant recognition rates can be attained for certain categories and with certain methods. Specifically, we show that a very good recognition rate is achieved in distinguishing colleagues from leisure-oriented dyads (families, couples and friends), whereas the distinction between the leisure-oriented dyads results to be inherently harder, but still possible at reasonable rates, in particular if families are restricted to parent-child groups. In general, we establish that the Bayesian method outperforms the functional metric one due, probably, to the difficulty of the latter to learn observable pdfs from individual trajectories.
en-copyright=
kn-copyright=

en-aut-name=YucelZeynep
en-aut-sei=Yucel
en-aut-mei=Zeynep
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ZanlungoFrancesco
en-aut-sei=Zanlungo
en-aut-mei=Francesco
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FelicianiClaudio
en-aut-sei=Feliciani
en-aut-mei=Claudio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=GregorjAdrien
en-aut-sei=Gregorj
en-aut-mei=Adrien
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KandaTakayuki
en-aut-sei=Kanda
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Computer Science, Okayama University
kn-affil=

affil-num=2
en-affil=Intelligent Robotics and Communication Laboratory, ATR
kn-affil=

affil-num=3
en-affil=Research Center for Advanced Science and Technology,The University of Tokyo
kn-affil=

affil-num=4
en-affil=Department of Computer Science, Okayama University
kn-affil=

affil-num=5
en-affil=Intelligent Robotics and Communication Laboratory, ATR
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=10
article-no=
start-page=e0218909
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191004
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Differential scanning fluorimetric analysis of the amino-acid binding to taste receptor using a model receptor protein, the ligand-binding domain of fish T1r2a/T1r3
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Taste receptor type 1 (T1r) is responsible for the perception of essential nutrients, such as sugars and amino acids, and evoking sweet and umami (savory) taste sensations. T1r receptors recognize many of the taste substances at their extracellular ligand-binding domains (LBDs). In order to detect a wide array of taste substances in the environment, T1r receptors often possess broad ligand specificities. However, the entire ranges of chemical spaces and their binding characteristics to any T1rLBDs have not been extensively analyzed. In this study, we exploited the differential scanning fluorimetry (DSF) to medaka T1r2a/T1r3LBD, a current sole T1rLBD heterodimer amenable for recombinant preparation, and analyzed their thermal stabilization by adding various amino acids. The assay showed that the agonist amino acids induced thermal stabilization and shifted the melting temperatures (T-m) of the protein. An agreement between the DSF results and the previous biophysical assay was observed, suggesting that DSF can detect ligand binding at the orthostericbinding site in T1r2a/T1r3LBD. The assay further demonstrated that most of the tested Lamino acids, but no D-amino acid, induced T-m shifts of T1r2a/T1r3LBD, indicating the broad L-amino acid specificities of the proteins probably with several different manners of recognition. The T-m shifts by each amino acid also showed a fair correlation with the responses exhibited by the full-length receptor, verifying the broad amino-acid binding profiles at the orthosteric site in LBD observed by DSF.
en-copyright=
kn-copyright=

en-aut-name=YoshidaTakashi
en-aut-sei=Yoshida
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YasuiNorihisa
en-aut-sei=Yasui
en-aut-mei=Norihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KusakabeYuko
en-aut-sei=Kusakabe
en-aut-mei=Yuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ItoChiaki
en-aut-sei=Ito
en-aut-mei=Chiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AkamatsuMiki
en-aut-sei=Akamatsu
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamashitaAtsuko
en-aut-sei=Yamashita
en-aut-mei=Atsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Food Research Institute, National Agriculture and Food Research Organization
kn-affil=

affil-num=4
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=6
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9
article-no=
start-page=1043
end-page=1052
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190319
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Acceleration of bone regeneration of horizontal bone defect in rats using collagen‐binding basic fibroblast growth factor combined with collagen scaffolds
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background</br>
Basic fibroblast growth factor (bFGF) has been applied for periodontal regeneration. However, the application depends on bone defect morphology because bFGF diffuses rapidly from defect sites. In a previous study, collagen‐binding bFGF (CB‐bFGF) has been shown to enhance bone formation by collagen‐anchoring in the orthopedic field. The aim of this study is to demonstrate the efficacy of CB‐bFGF with collagen scaffolds in bone regeneration of horizontal bone defect.</br>
Methods</br>
Cell proliferation activity and collagen binding activity of CB‐bFGF was confirmed by WST‐8 assay and collagen binding assay, respectively. The retention of CB‐bFGF in the collagen sheet (CS) was measured by fluorescence imaging. The rat horizontal alveolar bone defect model was employed to investigate the efficacy of CB‐bFGF with collagen powder (CP). After 4 and 8 weeks, the regenerative efficacy was evaluated by microcomputed tomography, histological, and immunohistochemical analyses.</br>
Results</br>
CB‐bFGF had a comparable proliferation activity to bFGF and a collagen binding activity. CB‐bFGF was retained in CS longer than bFGF. At 8 weeks postoperation, bone volume, bone mineral content, and new bone area in CB‐bFGF/CP group were significantly increased compared with those in other groups. Furthermore, epithelial downgrowth was significantly suppressed in CB‐bFGF/CP group. At 4 weeks, the numbers of osteocalcin, proliferating cell nuclear antigen, and osteopontin‐positive cells at the regeneration site in CB‐bFGF/CP group were greater than those in other groups.</br>
Conclusions</br>
CB‐bFGF/CP effectively promoted bone regeneration of horizontal bone defect possibly by sustained release of bFGF. The potential of CB‐bFGF composite material for improved periodontal regeneration in vertical axis was shown.
en-copyright=
kn-copyright=

en-aut-name=NakamuraShin
en-aut-sei=Nakamura
en-aut-mei=Shin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ItoTakashi
en-aut-sei=Ito
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OkamotoKentaro
en-aut-sei=Okamoto
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MimaTakehiko
en-aut-sei=Mima
en-aut-mei=Takehiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=UchidaKentaro
en-aut-sei=Uchida
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SiddiquiYasir D.
en-aut-sei=Siddiqui
en-aut-mei=Yasir D.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ItoMasahiro
en-aut-sei=Ito
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TaiMasako
en-aut-sei=Tai
en-aut-mei=Masako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OkuboKeisuke
en-aut-sei=Okubo
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=YamashiroKeisuke
en-aut-sei=Yamashiro
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=OmoriKazuhiro
en-aut-sei=Omori
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=YamamotoTadashi
en-aut-sei=Yamamoto
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=MatsushitaOsamu
en-aut-sei=Matsushita
en-aut-mei=Osamu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=TakashibaShogo
en-aut-sei=Takashiba
en-aut-mei=Shogo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Department of Pathophysiology‐Periodontal Science, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=2
en-affil=Department of Pathophysiology‐Periodontal Science, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Pathophysiology‐Periodontal Science, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Bacteriology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=5
en-affil=Department of Orthopedic Surgery, Kitasato University School of Medicine
kn-affil=

affil-num=6
en-affil=Department of Pathophysiology‐Periodontal Science, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Pathophysiology‐Periodontal Science, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Pathophysiology‐Periodontal Science, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Pathophysiology‐Periodontal Science, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Pathophysiology‐Periodontal Science, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=

affil-num=11
en-affil=Department of Periodontics and Endodontics, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Periodontics and Endodontics, Okayama University Hospital
kn-affil=

affil-num=13
en-affil=Department of Bacteriology, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Pathophysiology‐Periodontal Science, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine
kn-affil=
en-keyword=bone regeneration
kn-keyword=bone regeneration
en-keyword=collagen
kn-keyword=collagen
en-keyword=drug delivery systems
kn-keyword=drug delivery systems
en-keyword=growth factors
kn-keyword=growth factors
en-keyword=periodontitis
kn-keyword=periodontitis
en-keyword=tissue engineering
kn-keyword=tissue engineering
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=Suppl. 2
article-no=
start-page=S118
end-page=S119
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201903
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Impact of breast surgery in de novo stage IV breast cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The article, entitled “Impact of Breast Surgery in Primary Metastasized Breast Cancer Outcomes of the Prospective Randomized Phase III ABCSG-28 POSYTIVE Trial,” published in the /i>Annals of Surgery (1), is the third to study to prospectively evaluate the prognostic efficacy of breast surgery in patients with metastases (Table 1).
en-copyright=
kn-copyright=

en-aut-name=ShienTadahiko
en-aut-sei=Shien
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Okayama University Hospital
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=33
cd-vols=
no-issue=9
article-no=
start-page=10409
end-page=10424
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201909
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Role of intracellular Ca2+?based mechanotransduction of human periodontal ligament fibroblasts
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Human periodontal ligament (hPDL) fibroblasts are thought to receive mechanical stress (MS) produced by orthodontic tooth movement, thereby regulating alveolar bone remodeling. However, the role of intracellular calcium ([Ca2+]i)‐based mechanotransduction is not fully understood. We explored the MS‐induced [Ca2+]i responses both in isolated hPDL fibroblasts and in intact hPDL tissue and investigated its possible role in alveolar bone remodeling. hPDL fibroblasts were obtained from healthy donors' premolars that had been extracted for orthodontic reasons. The oscillatory [Ca2+]i activity induced by static compressive force was measured by a live‐cell Ca2+ imaging system and evaluated by several feature extraction method. The spatial pattern of cell‐cell communication was investigated by Moran's I , an index of spatial autocorrelation and the gap junction (GJ) inhibitor. The Ca2+‐transporting ionophore A23187 was used to further investigate the role of [Ca2+]i up‐regulation in hPDL cell behavior. hPDL fibroblasts displayed autonomous [Ca2+]i responses. Compressive MS activated this autonomous responsive behavior with an increased percentage of responsive cells both in vitro and ex vivo . The integration, variance, maximum amplitude, waveform length, and index J in the [Ca2+]i responses were also significantly increased, whereas the mean power frequency was attenuated in response to MS. The increased Moran's I after MS indicated that MS might affect the pattern of cell‐cell communication via GJs. Similar to the findings of MS‐mediated regulation, the A23187‐mediated [Ca2+]i uptake resulted in the up‐regulation of receptor activator of NF‐κB ligand (Rankl) and Sost along with increased sclerostin immunoreactivity, suggesting that [Ca2+]i signaling networks may be involved in bone remodeling. In addition, A23187‐treated hPDL fibroblasts also showed the suppression of osteogenic differentiation and mineralization. Our findings suggest that augmented MS‐mediated [Ca2+]i oscillations in hPDL fibroblasts enhance the production and release of bone regulatory signals via Rankl/Osteoprotegerin and the canonical Wnt/β‐catenin pathway as an early process in tooth movement?initiated alveolar bone remodeling.?Ei Hsu Hlaing, E., Ishihara, Y., Wang, Z., Odagaki, N., Kamioka, H. Role of intracellular Ca2+‐based mechanotransduction of human periodontal ligament fibroblasts. FASEB J. 33, 10409?10424 (2019).
en-copyright=
kn-copyright=

en-aut-name=HlaingEi Ei Hsu
en-aut-sei=Hlaing
en-aut-mei=Ei Ei Hsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaYoshihito
en-aut-sei=Ishihara
en-aut-mei=Yoshihito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangZiyi
en-aut-sei=Wang
en-aut-mei=Ziyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OdagakiNaoya
en-aut-sei=Odagaki
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KamiokaHiroshi
en-aut-sei=Kamioka
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Orthodontics, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Orthodontics and Dentofacial Orthopedics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=hPDL
kn-keyword=hPDL
en-keyword=intracellular calcium
kn-keyword=intracellular calcium
en-keyword=SOST/sclerostin
kn-keyword=SOST/sclerostin
en-keyword=Rankl/Opg
kn-keyword=Rankl/Opg
en-keyword=bone remodeling
kn-keyword=bone remodeling
END

start-ver=1.4
cd-journal=joma
no-vol=36
cd-vols=
no-issue=
article-no=
start-page=187
end-page=200
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Direct Measurement of Interaction Forces between Surfaces in Liquids Using Atomic Force Microscopy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The stability of particle suspensions, which is important in numerous industrial processes, is generally dominated by the interaction forces between the suspended particles. Understanding the interaction forces between surfaces in liquids is therefore fundamentally important in order to evaluate and control how particulates, including fluid droplets in emulsions and air bubbles in foams, behave in various systems. The invention of the surface force apparatus (SFA) enabled the direct measurement of interaction forces in liquids with molecular level resolution and it has led to remarkable progress in understanding surface forces in detail. Following the SFA, the application of atomic force microscopy (AFM) to force measurement has further extended the possibility of force measurements to a broad field of research, mainly due to the range of materials that can be employed. This review provides an overview of developments in the investigation of interaction forces between surfaces using AFM. The properties of various interaction forces, important in particle technology, revealed by the studies using AFM are described in detail.
en-copyright=
kn-copyright=

en-aut-name=IshidaNaoyuki
en-aut-sei=Ishida
en-aut-mei=Naoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=CraigVincent S. J.
en-aut-sei=Craig
en-aut-mei=Vincent S. J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Applied Mathematics, RSPE, Australian National University
kn-affil=
en-keyword=atomic force microscopy
kn-keyword=atomic force microscopy
en-keyword=interaction force
kn-keyword=interaction force
en-keyword=direct measurement
kn-keyword=direct measurement
en-keyword=liquid phase
kn-keyword=liquid phase
en-keyword=suspension stability
kn-keyword=suspension stability
END

start-ver=1.4
cd-journal=joma
no-vol=G3: Genes Genomes Genetics
cd-vols=
no-issue=1
article-no=
start-page=217
end-page=228
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201901
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Medaka Population Genome Structure and Demographic History Described via Genotyping-by-Sequencing
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Medaka is a model organism in medicine, genetics, developmental biology and population genetics. Lab stocks composed of more than 100 local wild populations are available for research in these fields. Thus, medaka represents a potentially excellent bioresource for screening disease-risk- and adaptation-related genes in genome-wide association studies. Although the genetic population structure should be known before performing such an analysis, a comprehensive study on the genome-wide diversity of wild medaka populations has not been performed. Here, we performed genotyping-by-sequencing (GBS) for 81 and 12 medakas captured from a bioresource and the wild, respectively. Based on the GBS data, we evaluated the genetic population structure and estimated the demographic parameters using an approximate Bayesian computation (ABC) framework. The genome-wide data confirmed that there were substantial differences between local populations and supported our previously proposed hypothesis on medaka dispersal based on mitochondrial genome (mtDNA) data. A new finding was that a local group that was thought to be a hybrid between the northern and the southern Japanese groups was actually an origin of the northern Japanese group. Thus, this paper presents the first population-genomic study of medaka and reveals its population structure and history based on chromosomal genetic diversity.
en-copyright=
kn-copyright=

en-aut-name=KatsumuraTakafumi
en-aut-sei=Katsumura
en-aut-mei=Takafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OdaShoji
en-aut-sei=Oda
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MitaniHiroshi
en-aut-sei=Mitani
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OotaHiroki
en-aut-sei=Oota
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo
kn-affil=

affil-num=3
en-affil=Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo
kn-affil=

affil-num=4
en-affil=Department of Anatomy, Kitasato University School of Medicine
kn-affil=
en-keyword=local population
kn-keyword=local population
en-keyword=freshwater fish
kn-keyword=freshwater fish
en-keyword=demography
kn-keyword=demography
en-keyword=RAD-seq
kn-keyword=RAD-seq
en-keyword=bioresource
kn-keyword=bioresource
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=5
article-no=
start-page=766
end-page=773
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190528
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Immunohistochemistry of YAP and dNp63 and survival analysis of patients bearing precancerous lesion and oral squamous cell carcinoma
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Yes-associated protein (YAP) is a candidate oncogene in various human cancers, and recently, it has been reported that YAP expression and its activity was enhanced by Delta Np63. However, the role of YAP and Delta Np63 expression in carcinogenesis and progression of oral squamous cell carcinoma (OSCC) has been unknown. Therefore, we investigated how YAP and Delta Np63 influence carcinogenesis and progression of OSCC. </br>

Methods: We performed immunohistochemical analyses in whole tissue samples to investigate YAP and Delta Np63 expression in normal oral mucosa, epithelial hyperplasia, oral epithelial dysplasia (OED; low/high grade), carcinoma in situ (CIS), and OSCC. Furthermore, in OSCC, we analyzed clinical significance by using Kaplan-Meier survival analysis. 

Results: In normal oral mucosa and epithelial hyperplasia, YAP expression was primarily confined to the basal and parabasal layers, but YAP expression was elevated in OED, CIS, and OSCC. In OED, YAP and Delta Np63 expression levels were markedly higher in high grade than in low grade. In OSCC groups, YAP and Delta Np63 expression patterns tended to differ according to histopathological differentiation of OSCC. Furthermore, the YAP high expression group, which showed YAP staining in >50% positive cells with strong cytoplasmic staining or >10% positive cells with nuclear reactivity, showed a tendency to have a poor survival rate. </br>

Conclusion: YAP and Delta Np63 expression levels correlated with grade of oral OED. Additionally, YAP expression was associated with OSCC survival rate. Our results suggested that YAP and Delta Np63 expression might serve as predictive markers to distinguish OSCC development and progression.
en-copyright=
kn-copyright=

en-aut-name=OnoSawako
en-aut-sei=Ono
en-aut-mei=Sawako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakanoKeisuke
en-aut-sei=Nakano
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakabatakeKiyofumi
en-aut-sei=Takabatake
en-aut-mei=Kiyofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil= Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil= Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=YAP
kn-keyword=YAP
en-keyword=ΔNp63
kn-keyword=ΔNp63
en-keyword=oral epithelial dysplasia
kn-keyword=oral epithelial dysplasia
en-keyword=carcinoma in situ
kn-keyword=carcinoma in situ
en-keyword=oral squamous cell carcinoma
kn-keyword=oral squamous cell carcinoma
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=1
article-no=
start-page=77
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191125
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Anesthetic management of a patient with sodium-channel myotonia: a case report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Sodium-channel myotonia (SCM) is a nondystrophic myotonia, characterized by pure myotonia without muscle weakness or paramyotonia. The prevalence of skeletal muscle channelopathies is approximately 1 in 100,000, and the prevalence of SCM is much lower. To our knowledge, this is the first report on anesthetic management of a patient with SCM. </br>
Case presentation: A 23-year-old woman with congenital nasal dysplasia and SCM was scheduled to undergo rhinoplasty with autologous costal cartilage. Total intravenous anesthesia without muscle relaxants was administered followed by continuous intercostal nerve block. Although transient elevation of potassium level in the blood was observed during surgery, the patient did not show exacerbation of myotonic or paralytic symptoms in the postoperative period. </br>
Conclusion: Total intravenous anesthesia and peripheral nerve block can be administered safely to a patient with SCM. However, careful monitoring of the symptoms and electrolytes is recommended.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoNaohisa
en-aut-sei=Matsumoto
en-aut-mei=Naohisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NishimotoRei
en-aut-sei=Nishimoto
en-aut-mei=Rei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsuokaYoshikazu
en-aut-sei=Matsuoka
en-aut-mei=Yoshikazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakedaYoshimasa
en-aut-sei=Takeda
en-aut-mei=Yoshimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MorimatsuHiroshi
en-aut-sei=Morimatsu
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
kn-affil=

affil-num=4
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Anesthesiology and Resuscitology, Okayama University Hospital
kn-affil=
en-keyword=Anesthetic management
kn-keyword=Anesthetic management
en-keyword=Myotonia congenita
kn-keyword=Myotonia congenita
en-keyword=Nondystrophic myotonia
kn-keyword=Nondystrophic myotonia
en-keyword=Paramyotonia congenita
kn-keyword=Paramyotonia congenita
en-keyword=Periodic paralysis
kn-keyword=Periodic paralysis
en-keyword=Potassium-aggravated myotonia
kn-keyword=Potassium-aggravated myotonia
en-keyword=Skeletal muscle channelopathy
kn-keyword=Skeletal muscle channelopathy
en-keyword=Sodium-channel myotonia
kn-keyword=Sodium-channel myotonia
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=5
article-no=
start-page=206
end-page=208
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Myxedema coma accompanied by sick sinus syndrome and hypoventilation: A case report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Myxedema coma is an emergency presentation of hypothyroidism, and cardiopulmonary manifestations of the disease are related to a high mortality rate. We herein report a case of myxedema coma accompanied by sick sinus syndrome requiring temporary cardiac pacing and hypercapnic respiratory failure in an 87-year-old woman. This case is unique because both of the cardiac and pulmonary manifestations were reversible and successfully treated with thyroid hormone replacement. Our case indicates that early detection of the condition and administration of levothyroxine are essential to improve the life-threatening condition and avoid invasive treatment such as permanent pacemaker implantation or intubation.
en-copyright=
kn-copyright=

en-aut-name=HaradaKo
en-aut-sei=Harada
en-aut-mei=Ko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MurakamiShuntaro
en-aut-sei=Murakami
en-aut-mei=Shuntaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TokumasuKazuki
en-aut-sei=Tokumasu
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TogawaYu
en-aut-sei=Togawa
en-aut-mei=Yu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Internal Medicine, Kaneda Hospital
kn-affil=

affil-num=5
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=hypercapnic respiratory failure
kn-keyword=hypercapnic respiratory failure
en-keyword=myxedema coma
kn-keyword=myxedema coma
en-keyword=sick sinus syndrome
kn-keyword=sick sinus syndrome
END

start-ver=1.4
cd-journal=joma
no-vol=530
cd-vols=
no-issue=
article-no=
start-page=115887
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191023
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Grain boundary diffusion of W in lower mantle phase with implications for isotopic heterogeneity in oceanic island basalts by core-mantle interactions
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Tungsten isotopes provide important constraints on the ocean-island basalt (OIB) source regions. Recent analyses of μ182W in modern basalts with high 3He/4He originating from the core-mantle boundary region reveal two distinct features: positive μ182W in Phanerozoic flood basalts indicating the presence of primordial reservoir, and negative μ182W in modern OIBs. One possibility to produce large variations in μ182W is interaction between the mantle and outer core. Here, we report grain boundary diffusion of W in lower mantle phases. High pressure experimental results show that grain boundary diffusion of W is fast and strongly temperature dependent. Over Earth's history, diffusive transport of W from the core to the lowermost mantle may have led to significant modification of the W isotopic composition of the lower mantle at length scales exceeding one kilometer. Such grain boundary diffusion can lead to large variations in μ182W in modern basalts as a function of the distance of their source regions from the core mantle boundary. Modern oceanic island basalts from Hawaii, Samoa and Iceland exhibit negative μ182W and likely originated from the modified isotope region just above the core-mantle boundary, whereas those with positive μ182W could be derived from the thick Large Low Shear Velocity Provinces (LLSVPs) far from the core-mantle boundary (CMB). When highly-oxidized slabs accumulate at the CMB oxidizing the outer core at the interface, a large W flux with negative μ182W can be added to the silicate mantle. As a result, the source region of the OIB would be effectively modified to a negative μ182W.
en-copyright=
kn-copyright=

en-aut-name=YoshinoTakashi
en-aut-sei=Yoshino
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MakinoYoshiki
en-aut-sei=Makino
en-aut-mei=Yoshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzukiToshihiro
en-aut-sei=Suzuki
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HirataTakafumi
en-aut-sei=Hirata
en-aut-mei=Takafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=Geochemical Research Center, The University of Tokyo
kn-affil=

affil-num=3
en-affil=Geochemical Research Center, The University of Tokyo
kn-affil=

affil-num=4
en-affil=Geochemical Research Center, The University of Tokyo
kn-affil=
en-keyword=core mantle interaction
kn-keyword=core mantle interaction
en-keyword=grain boundary diffusion
kn-keyword=grain boundary diffusion
en-keyword=high pressure experiment
kn-keyword=high pressure experiment
en-keyword=postspinel
kn-keyword=postspinel
en-keyword=W isotope
kn-keyword=W isotope
en-keyword=core mantle boundary
kn-keyword=core mantle boundary
END

start-ver=1.4
cd-journal=joma
no-vol=17
cd-vols=
no-issue=
article-no=
start-page=116
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190808
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Analysis of the role of the Hippo pathway in cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cancer is a serious health issue in the world due to a large body of cancer-related human deaths, and there is no current treatment available to efficiently treat the disease as the tumor is often diagnosed at a serious stage. Moreover, Cancer cells are often resistant to chemotherapy, radiotherapy, and molecular-targeted therapy. Upon further knowledge of mechanisms of tumorigenesis, aggressiveness, metastasis, and resistance to treatments, it is necessary to detect the disease at an earlier stage and for a better response to therapy. The hippo pathway possesses the unique capacity to lead to tumorigenesis. Mutations and altered expression of its core components (MST1/2, LATS1/2, YAP and TAZ) promote the migration, invasion, malignancy of cancer cells. The biological significance and deregulation of it have received a large body of interests in the past few years. Further understanding of hippo pathway will be responsible for cancer treatment. In this review, we try to discover the function of hippo pathway in different diversity of cancers, and discuss how Hippo pathway contributes to other cellular signaling pathways. Also, we try to describe how microRNAs, circRNAs, and ZNFs regulate hippo pathway in the process of cancer. It is necessary to find new therapy strategies for cancer.
en-copyright=
kn-copyright=

en-aut-name=HanYanyan
en-aut-sei=Han
en-aut-mei=Yanyan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=Hippo pathway
kn-keyword=Hippo pathway
en-keyword=YAP/TAZ
kn-keyword=YAP/TAZ
en-keyword=Cancer
kn-keyword=Cancer
END

start-ver=1.4
cd-journal=joma
no-vol=49
cd-vols=
no-issue=1
article-no=
start-page=27
end-page=34
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190525
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fourth molar: A retrospective study and literature review of a rare clinical entity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose
The prevalence of supernumerary teeth has been reported to be between 0.1% and 3.8%. The aim of this study was to determine the prevalence, clinical significance, and associated pathologies of fourth molars based on a retrospective study and a literature review.

Materials and Methods
A 5-year retrospective prevalence study was conducted at the Department of Oral Diagnosis and Dentomaxillofacial Radiology of Okayama University Hospital, Okayama, Japan. The study involved extracting data from the digital records of patients from January 1, 2013 through December 31, 2017. The sampling frame included all patients who had panoramic radiographs, cone-beam computed tomography (CT), and multislice CT images during the period under review.

Results
A total of 26,721 cases were reviewed and 87 fourth molars were identified. The prevalence of fourth molars in the 5-year study at Okayama was calculated as 0.32%. The mean age of patients with a fourth molar was 30.43 years, and the male-to-female ratio was 1:0.98. The vast majority of cases were in the maxilla (92%) and had normal shapes (89.7%); furthermore, 82.8% of cases were unerupted.

Conclusion
The prevalence of fourth molars in the study population was found to be 0.32%, and fourth molars occurred with approximately equal frequency in males and females. Fourth molars were more common in the maxilla and were predominantly unerupted and small.
en-copyright=
kn-copyright=

en-aut-name=BamgboseBabatunde O.
en-aut-sei=Bamgbose
en-aut-mei=Babatunde O.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkadaShunsuke
en-aut-sei=Okada
en-aut-mei=Shunsuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HisatomiMiki
en-aut-sei=Hisatomi
en-aut-mei=Miki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YanagiYoshinobu
en-aut-sei=Yanagi
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakeshitaYohei
en-aut-sei=Takeshita
en-aut-mei=Yohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=AbduZahrau Saleh
en-aut-sei=Abdu
en-aut-mei=Zahrau Saleh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=EkuaseEdugie J.
en-aut-sei=Ekuase
en-aut-mei=Edugie J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=AsaumiJun-ichi
en-aut-sei=Asaumi
en-aut-mei=Jun-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral Diagnostic Sciences, Faculty of Dentistry, Bayero University Kano
kn-affil=

affil-num=7
en-affil=Department of Chemistry and Forensic Sciences, Savannah State University
kn-affil=

affil-num=8
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Tooth
kn-keyword=Tooth
en-keyword=Supernumerary
kn-keyword=Supernumerary
en-keyword=Odontoma
kn-keyword=Odontoma
en-keyword=Odontogenic Cyst
kn-keyword=Odontogenic Cyst
END

start-ver=1.4
cd-journal=joma
no-vol=22
cd-vols=
no-issue=3
article-no=
start-page=458
end-page=466
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Transition-metal(ii) complexes with a tripodal hexadentate ligand, 1,1,1-tris[2-aza-3-(imidazol-4-yl)prop-2-enyl]ethane, exhibiting incomplete total or absolute spontaneous resolution
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Crystal structures and crystallisation behaviours of a series of first-row transition-metal(II) complexes bearing 1,1,1-tris[2-aza-3-(imidazol-4-yl)prop-2-enyl]ethane (H3L), [MII(H3L)]Cl(ClO4) (M = Mn, Fe, Co, Ni and Zn) were examined. These compounds crystallise in an orthorhombic crystal system with a non-enantiogenic (Sohncke) space group P212121, resulting in spontaneous resolution of the chiral complex cations. Hydrogen bonds between the imidazole N?H atoms in the tripodal ligand and chloride anions give enantiomorphic crystals with a homochiral three-dimensional network structure. In order to verify the spontaneous resolution of these compounds, solid-state circular dichroism spectra of the resulting single crystals were measured (KBr disk method). Unexpectedly, the observed spectra indicated that imbalanced formation of the enantiomorphic crystals (i.e., left-handed Λ-form vs. right-handed Δ-form complex cations) in all cases. Moreover, in the cases of NiII and ZnII compounds, predominant enantiomorphic crystals formed by spontaneous resolution were always the same (in at least ten of our recrystallisation experiments). These observations suggest that there is a certain (but as yet unknown) factor that affects the predominant deposition of either enantiomorphic crystal when spontaneous resolution takes place from a solution of a racemic mixture in which rapid racemisation occurs.
en-copyright=
kn-copyright=

en-aut-name=MatsushimaMisaki
en-aut-sei=Matsushima
en-aut-mei=Misaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=WadaKoki
en-aut-sei=Wada
en-aut-mei=Koki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakaharaKazuma
en-aut-sei=Takahara
en-aut-mei=Kazuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SunatsukiYukinari
en-aut-sei=Sunatsuki
en-aut-mei=Yukinari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SuzukiTakayoshi
en-aut-sei=Suzuki
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=1
article-no=
start-page=115
end-page=135
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191003
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A proposal of Android Programming Learning Assistant System with implementation of basic application learning
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose</br>
With rapid increase of Android devices and application systems, there is a strong demand for Android application programmers. A lot of schools are offering Android programming courses to meet this demand. However, Android programming can be different from the conventional one because it needs interactive functions through interfaces with users, which makes the study more difficult. This paper aims to propose an Android Programming Learning Assistance System, namely, APLAS, to assist the Java-based Android programming study and education.</br>
Design/methodology/approach</br>
By adopting the test-driven development method, APLAS is designed to achieve independent learning without the presence of teachers. Using JUnit and Robolectric, the answers from the students are automatically marked in APLAS. To cover extensive materials in Android programming, APLAS offers four stages where each stage involves several topics.</br>
Findings</br>
To evaluate the effectiveness of APLAS, we implemented the Unit Converter assignment that covers the first two topics, namely, Basic user interface in the first stage and basic activity in the second stage. Through solving the assignment, it is expected to learn basic application development. Forty novice students of an IT department in Indonesia were asked to solve both topics separately.</br>
Originality/value</br>
The results show that APLAS is useful and helpful for the self-study of Android programming, as they could complete codes with good execution performances.
en-copyright=
kn-copyright=

en-aut-name=SyaifudinYan Watequlis
en-aut-sei=Syaifudin
en-aut-mei=Yan Watequlis
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FunabikiNobuo
en-aut-sei=Funabiki
en-aut-mei=Nobuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KuribayashiMinoru
en-aut-sei=Kuribayashi
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KaoWen-Chung
en-aut-sei=Kao
en-aut-mei=Wen-Chung
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Electrical and Communication Engineering, Okayama University
kn-affil=

affil-num=4
en-affil=National Taiwan Normal University
kn-affil=
en-keyword=Android application
kn-keyword=Android application
en-keyword=APLAS
kn-keyword=APLAS
en-keyword=JUnit
kn-keyword=JUnit
en-keyword=Learning system
kn-keyword=Learning system
en-keyword= Learning system
kn-keyword= Learning system
en-keyword=Test-driven development method
kn-keyword=Test-driven development method
en-keyword=Index terms APLAS
kn-keyword=Index terms APLAS
en-keyword=Java
kn-keyword=Java
END

start-ver=1.4
cd-journal=joma
no-vol=220
cd-vols=
no-issue=1
article-no=
start-page=190
end-page=200
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190930
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Deformation of rhyolite lava crust associated with intermittent inner flow of lava: palaeomagnetic evidence
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A palaeomagnetic study has been conducted to examine the deformation of thick crusts of rhyolite lava while its inner portions continue to flow. The Sanukayama rhyolite lava, which erupted in the Pleistocene in Kozushima Island, Japan, was chosen as the investigation site because of its well-exposed vertical lithofacies variations classified into three distinct zones (pumiceous, obsidian and crystalline). The targets of this study are the pumiceous and obsidian zones, which constitute the crust of the lava. Thermal demagnetization reveals three remanent magnetization components from the pumiceous and obsidian samples but only a single magnetization component from the inner crystalline rhyolite samples. Alternating field demagnetization is ineffective in isolating the magnetization components in the pumiceous and obsidian samples. The multiple components of remanent magnetization of the crust are interpreted to have been acquired during cooling as thermoremanent magnetizations. We suspect intermittent lava transport of the inner portions, the primary mode of rhyolite lava advancement, to be responsible for the presence of multiple components in pumice and obsidian of the lava crust. When the inner portions of the lava retain mobility to flow out of the crust, the solidified crust of the lava surface below the magnetite Curie temperature remains susceptible to deformation. Analysis of palaeomagnetic directions from the crust allows the deformation of the crust to be described in terms of rotation. Although the mode of rhyolite lava advancement is not well understood, because of its infrequent occurrence, our observations offer an important insight on how the mobile part of the lava is associated with the deformation of the crust during continued lava advance.
en-copyright=
kn-copyright=

en-aut-name=UnoKoji
en-aut-sei=Uno
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FurukawaKuniyuki
en-aut-sei=Furukawa
en-aut-mei=Kuniyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakaiKotaro
en-aut-sei=Nakai
en-aut-mei=Kotaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KamioTakuma
en-aut-sei=Kamio
en-aut-mei=Takuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KanamaruTatsuo
en-aut-sei=Kanamaru
en-aut-mei=Tatsuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Business Administration, Aichi University
kn-affil=

affil-num=3
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Earth Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Earth and Environmental Sciences, Nihon University
kn-affil=
en-keyword=Asia
kn-keyword=Asia
en-keyword=Palaeomagnetism
kn-keyword=Palaeomagnetism
en-keyword=Rock and mineral magnetism
kn-keyword=Rock and mineral magnetism
en-keyword=Volcanic hazards and risks
kn-keyword=Volcanic hazards and risks
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=裏表紙・目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学地球科学研究報告 投稿規定（約款）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=37
end-page=49
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Synoptic climatological analyses of daily precipitation features and atmospheric fields in warm season relating to the precipitation difference between Kochi and Okayama characterizing the Seto Inland Sea Climate in Japan
kn-title=高知・岡山間の降水量差形成に関わる暖候期の日々の降水や大気場の総観気候学的解析（瀬戸内式気候に関連して）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= In order to re-examine the formation process of the climatological precipitation difference between Kochi (Pacific side of Shikoku District) and Okayama (Seto Inland Sea side) characterizing the Seto Island Sea Climate in warm season, synoptic climatological analyses of the daily precipitation features and atmospheric fields were performed for the warm season (April to September) of 1985 - 2015, based on the daily and hourly precipitation data and weather maps by the Japan Meteorological Agency (JMA), and the NCEP/NCAR re-analysis data. The large climatological difference of precipitation at Kochi from that at Okayama throughout the warm season was greatly contributed to by the days with the precipitation difference between Kochi and Okayama (ΔPR) with greater equal to 30 mm/day. In addition, such large daily ΔPR was mainly due to the intense rainfall at Kochi with greater equal to 10mm/h throughout the warm season, except for a part of the cases in April when the “not so intense rain” with less than 10mm/h at Kochi contributed to the large ΔPR. However, it is noted that the features of the synoptic-scale atmospheric fields and possible roles of the mountain ranges in Shikoku District causing the large ΔPR were rather different among August (midsummer), September (Autumn rainfall season) and April (Spring) .
en-copyright=
kn-copyright=

en-aut-name=KatoKuranoshin
en-aut-sei=Kato
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進
kn-aut-sei=加藤
kn-aut-mei=内藏進
aut-affil-num=1
ORCID=

en-aut-name=SUGIMURAYuki
en-aut-sei=SUGIMURA
en-aut-mei=Yuki
kn-aut-name=杉村裕貴
kn-aut-sei=杉村
kn-aut-mei=裕貴
aut-affil-num=2
ORCID=

en-aut-name=MATSUMOTOKengo
en-aut-sei=MATSUMOTO
en-aut-mei=Kengo
kn-aut-name=松本健吾
kn-aut-sei=松本
kn-aut-mei=健吾
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科

affil-num=2
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
en-keyword=Daily precipitation climatology
kn-keyword=Daily precipitation climatology
en-keyword=Climate around Japan
kn-keyword=Climate around Japan
en-keyword=Seto Inland Sea Climate in Japan
kn-keyword=Seto Inland Sea Climate in Japan
en-keyword=Synoptic climatology
kn-keyword=Synoptic climatology
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=25
end-page=36
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Interdisciplinary ESD lesson study for the university students with attention to the difference of climate and seasonal feeling in “summer” among Germany, northern Europe and Japan
kn-title=ドイツ・北欧と日本の「夏」の気候や季節感の違いに注目して音楽と連携した大学での学際的ESD授業開発
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Climatological features and seasonal feeling in the season called by the same word such as “summer”would be rather different from region to region. Comparison of these features among the different regions, including the regions which are not so familiar to the students, would help to promote their fundamental ESD literacy, especially relating to the “Understanding of heterogeneous others”. Based on that concept, this paper will report an interdisciplinary lesson study for the university students on a theme how different the summertime climate and seasonal feeling among Germany, northern Europe and Japan are. In this study, the lesson practice was made in 2015 and 2018. In both classes, after the lecture on the summertime climate and seasonal feeling in these regions, the students created substitute songs with use of the melody of “Alles neu macht der Mai” (“The May makes all things new”, the same melody as a Japanese school song “Butterfly”) for the comparison between Germany and Japan. As for that between northern Europe, the melody of a Japanese school song “Furu-Sato” (“My country home”) was used for the creation of the substitute songs. It is noted that, not only the seasonal mean temperature or solar radiation condition, but also the features in association with the large day-to-day temperature variation was strongly reflected in the students’ works.
en-copyright=
kn-copyright=

en-aut-name=KATOKuranoshin
en-aut-sei=KATO
en-aut-mei=Kuranoshin
kn-aut-name=加藤内藏進
kn-aut-sei=加藤
kn-aut-mei=内藏進
aut-affil-num=1
ORCID=

en-aut-name=KATOHaruko
en-aut-sei=KATO
en-aut-mei=Haruko
kn-aut-name=加藤晴子
kn-aut-sei=加藤
kn-aut-mei=晴子
aut-affil-num=2
ORCID=

en-aut-name=OTANIKazuo
en-aut-sei=OTANI
en-aut-mei=Kazuo
kn-aut-name=大谷和男
kn-aut-sei=大谷
kn-aut-mei=和男
aut-affil-num=3
ORCID=

en-aut-name=MATSUMOTOKengo
en-aut-sei=MATSUMOTO
en-aut-mei=Kengo
kn-aut-name=松本健吾
kn-aut-sei=松本
kn-aut-mei=健吾
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Education, Okayama University
kn-affil=岡山大学大学院教育学研究科

affil-num=2
en-affil=Faculty of Education, Gufu Shotoku Gakuen University
kn-affil=岐阜聖徳学園大学教育学部

affil-num=3
en-affil=TV Setouchi Broadcasting Co., LTD.
kn-affil=テレビせとうち(株)

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
en-keyword=Interdisciplinary collaboration between climate and cultural understanding education
kn-keyword=Interdisciplinary collaboration between climate and cultural understanding education
en-keyword=ESD
kn-keyword=ESD
en-keyword=Comparative climatology
kn-keyword=Comparative climatology
en-keyword=Regional difference of summer climate
kn-keyword=Regional difference of summer climate
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=19
end-page=24
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Schistose fault related rocks from the Sangun Metamorphic Rocks, Kawakita area, Misaki Town, Okayama Prefecture, SW Japan
kn-title=美咲町川北地域に分布する三郡変成岩から見出された片岩化した断層岩
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The crystalline schist which is representatively exposed in the Innerside of Southwest Japan is called the Sangun Metamorphic Rocks (SMR). In Kawakita area, Misaki Town, Okayama Prefecture, schistose fault rocks which is newly described in below are intercalated in the SMR. The rocks are composed of lenticular fragments of pelitic, basic siliceous rocks and quartz vein with siliceous to pelitic matrix. The fine-grained muscovites which define schistosity penetrate the rocks. Major direction of layer which though to reflect slip plane is subparallel to the schistosity. The long axis of some fragments are slightly oblique to the schistosity. The combination of the two sets of planes is considered to be a composite planar fabric. These occurrences suggest that the rocks are fault rock before the Sangun Metamorphism and named as schistose fault rocks. Lenses of cataclasite and myronite are accompanied. Planar thin (about 10cm in thickness) brittle fault rock is also associated. These shear deformed rocks form units of layer (shear zone) of 10 to 100m in thickness, and are concordantly intercalated in the surrounded normal schists. Active periods of the shear zones had several times from before and after the event of the Sangun Metamorphism.
en-copyright=
kn-copyright=

en-aut-name=MATSUSHITAMirei
en-aut-sei=MATSUSHITA
en-aut-mei=Mirei
kn-aut-name=松下実礼
kn-aut-sei=松下
kn-aut-mei=実礼
aut-affil-num=1
ORCID=

en-aut-name=SUZUKIShigeyuki
en-aut-sei=SUZUKI
en-aut-mei=Shigeyuki
kn-aut-name=鈴木茂之
kn-aut-sei=鈴木
kn-aut-mei=茂之
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
en-keyword=Sangun Metamorphic Rocks
kn-keyword=Sangun Metamorphic Rocks
en-keyword=regional metamorphism
kn-keyword=regional metamorphism
en-keyword=shear deformation
kn-keyword=shear deformation
en-keyword=schistose fault rock
kn-keyword=schistose fault rock
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=1
end-page=17
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Computation of non-linear site response by the time-domain finite-difference method
kn-title=時間領域差分法による表層地盤の非線形応答の計算
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= We have developed a time-domain staggered-grid finite-difference code for modeling non-linear response of a one-dimensionally inhomogeneous subsurface structure to a SH plane-wave incidence. It employs the velocity-stress formulation of elastodynamic equation for the linear part, and adopts a elastoplastic rheology model for the non-linear relation between the stress and strain. In this paper, we apply this code to four constitutive models from linear-elastic to nonlinear: (1) linear elastic model, (2) linear viscoelastic model, (3) elastoplastic model, and (4) viscoelastoplastic model, which simulate shallow sand and clay structures and are vibrated by a vertically incident SH plane-wave of Ricker wavelet, to compare the linear and the non-linear soil behaviors including low strains damping (viscoelastic effect) and/or hysteretic attenuation (non-linear effect). We also apply it to a local strong-motion record of the 2000 Western-Tottori earthquake (MW6.8). We then simulate characteristics of non-linear site response such as reduction of the spectral amplitude in the high frequency band and shift of the peak frequencies to lower frequencies.
en-copyright=
kn-copyright=

en-aut-name=TORIGOEYusuke
en-aut-sei=TORIGOE
en-aut-mei=Yusuke
kn-aut-name=鳥越友輔
kn-aut-sei=鳥越
kn-aut-mei=友輔
aut-affil-num=1
ORCID=

en-aut-name=KOMATSUMasanao
en-aut-sei=KOMATSU
en-aut-mei=Masanao
kn-aut-name=小松正直
kn-aut-sei=小松
kn-aut-mei=正直
aut-affil-num=2
ORCID=

en-aut-name=TAKENAKAHiroshi
en-aut-sei=TAKENAKA
en-aut-mei=Hiroshi
kn-aut-name=竹中博士
kn-aut-sei=竹中
kn-aut-mei=博士
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of Earth Sciences, Faculty of Science, Okayama University
kn-affil=岡山大学理学部地球科学科

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=岡山大学大学院自然科学研究科
en-keyword=finite-difference method
kn-keyword=finite-difference method
en-keyword=non-linear site response
kn-keyword=non-linear site response
en-keyword=strong motion
kn-keyword=strong motion
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Title Page
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=1
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙・英文目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=50
cd-vols=
no-issue=2
article-no=
start-page=184
end-page=191
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190618
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comparison of the clinical characteristics of TAFRO syndrome and idiopathic multicentric Castleman disease in general internal medicine: a 6‐year retrospective study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background</br>
Although thrombocytopenia, anasarca, fever, reticulin fibrosis and organomegaly (TAFRO) syndrome was first described as a variant of idiopathic multicentric Castleman disease (CD), patients with TAFRO syndrome demonstrate more aggressive clinical features. Because these patients may present with fever of unknown origin, general physicians need to recognise its characteristic laboratory data and clinical features during hospitalisation.</br>
Aims</br>
to describe the features, symptoms and characteristics of TAFRO syndrome and to compare them to those of idiopathic CD.</br>
Methods</br>
This was a retrospective study of patients with histopathologically confirmed TAFRO syndrome and idiopathic multicentric CD who were diagnosed and managed between April 2012 and June 2018 in a Japanese university hospital's General Medicine Department.</br>
Results</br>
We found that the hospitalisations were significantly longer among patients with TAFRO syndrome compared to those with idiopathic CD (median: 87 days; range: 34?236 days vs median: 30 days; range: 13?59 days; P < 0.01). Patients with TAFRO syndrome were more likely to present with fever, abdominal pain and elevated inflammatory markers and be misdiagnosed with an infectious disease during the first hospital visit. Approximately 40% of patients with TAFRO syndrome had no radiographically enlarged lymph nodes.</br>
Conclusions</br>
TAFRO syndrome may present as an infectious disease with an aggressive clinical course. Our study highlights the importance of giving significance to chief complaints and laboratory data. Physicians need to recognise the clinical and laboratory features of this disease to avoid missing this potentially fatal disorder.
en-copyright=
kn-copyright=

en-aut-name=NishimuraYoshito
en-aut-sei=Nishimura
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=Hanayama Yoshihisa
en-aut-sei=Hanayama
en-aut-mei= Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiiNobuharu
en-aut-sei=Fujii
en-aut-mei=Nobuharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KondoEisei
en-aut-sei=Kondo
en-aut-mei=Eisei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology, Kawasaki Medical School
kn-affil=

affil-num=5
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=TAFRO syndrome
kn-keyword=TAFRO syndrome
en-keyword=Castleman disease
kn-keyword=Castleman disease
en-keyword=chief complaint
kn-keyword=chief complaint
en-keyword=procalcitonin
kn-keyword=procalcitonin
en-keyword=immunoglobulin
kn-keyword=immunoglobulin
END

start-ver=1.4
cd-journal=joma
no-vol=15
cd-vols=
no-issue=
article-no=
start-page=2069
end-page=2080
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191128
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Near-Optimal Detection for Binary Tardos Code by Estimating Collusion Strategy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A previously proposed optimal detector for bias-based fingerprinting codes such as Tardos and Nuida requires two kinds of important information: the number of colluders and the collusion strategy used to generate the pirated codeword. An estimator has now been derived for these two parameters. The bias in the pirated codeword is measured by observing the number of zeros and ones and compared with possible bias patterns calculated using information about the collusion strategy and number of colluders. Computer simulation demonstrated that the collusion strategy and number of colluders can be estimated with high probability and that the traceability of a detector using the proposed estimator is extremely close to being optimal.
en-copyright=
kn-copyright=

en-aut-name=Yasui Tatsuya
en-aut-sei=Yasui
en-aut-mei= Tatsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KuribayashiMinoru
en-aut-sei=Kuribayashi
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FunabikiNobuo
en-aut-sei=Funabiki
en-aut-mei=Nobuo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=EchizenIsao
en-aut-sei=Echizen
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=National Institute of Informatics
kn-affil=
en-keyword=fingerprinting code
kn-keyword=fingerprinting code
en-keyword=optimal detector
kn-keyword=optimal detector
en-keyword=collusion strategy
kn-keyword=collusion strategy
en-keyword=number of colluders
kn-keyword=number of colluders
en-keyword=estimator
kn-keyword=estimator
END

start-ver=1.4
cd-journal=joma
no-vol=284
cd-vols=
no-issue=
article-no=
start-page=63
end-page=79
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190411
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Portfolio allocation problems between risky and ambiguous assets
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This paper considers a portfolio allocation problem between a risky asset and an ambiguous asset, and investigates how greater ambiguity aversion influences the optimal proportion invested in the two assets. We derive several sufficient conditions under which greater ambiguity aversion decreases the optimal proportion invested in the ambiguous asset. Furthermore, we consider an international diversification problem as an application and show that ambiguity aversion partially resolves the home bias puzzle.
en-copyright=
kn-copyright=

en-aut-name=AsanoTakao
en-aut-sei=Asano
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OsakiYusuke
en-aut-sei=Osaki
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Faculty of Economics, Okayama University
kn-affil=

affil-num=2
en-affil=Faculty of Commerce, Waseda University
kn-affil=
en-keyword=Uncertainty modelling
kn-keyword=Uncertainty modelling
en-keyword=Home bias puzzle
kn-keyword=Home bias puzzle
en-keyword=Portfolio allocation problem
kn-keyword=Portfolio allocation problem
en-keyword=Smooth ambiguity model
kn-keyword=Smooth ambiguity model
en-keyword=Greater ambiguity aversion
kn-keyword=Greater ambiguity aversion
END

start-ver=1.4
cd-journal=joma
no-vol=257
cd-vols=
no-issue=
article-no=
start-page=662
end-page=662
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190122
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Magnetic resonance imaging findings of age-related distance esotropia in Japanese patients with high myopia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Purpose<br/>
This study aimed to investigate the characteristics of the extraocular muscles and the orbital connective tissue pulleys in Japanese patients with age-related distance esotropia (ARDE) and high myopia using magnetic resonance imaging (MRI).<br/>
Methods<br/>
This was a retrospective case-series study. High-resolution coronal MRI scans of 12 orbits were obtained in 6 patients with ARDE and high myopia (age range: 51?69 years). We analyzed the images to determine the positions of the rectus muscle pulleys relative to the center of the globe, the integrity of the lateral rectus-superior rectus muscle (LR-SR) band, and the LR angle (the angle between the major axis of the LR and the vertical plane).<br/>
Results<br/>
The distance esotropia ranged from 4 to 25?, and 3 cases exhibited vertical deviations. The mean (±standard deviation (SD)) axial length was 28.5 (± 1.6) mm. The mean positions of the medial rectus muscle pulley and LR pulley were 1.3 mm inferior and 1.4 mm inferior, respectively, to those seen in the normal control group in our previous study (P?=?0.002 and P?=?0.05, respectively). All 12 orbits had abnormal elongated LR-SR bands, and 8 orbits (67%) displayed ruptured LR-SR bands. The LR angle (mean±SD; 18.8°?±?8.5°) increased significantly with the inferior displacement of the LR pulley (R2?=?0.77, P?=?0.0002).<br/>
Conclusions<br/>
Inferior displacement of the LR pulley and abnormal LR-SR bands were seen in Japanese ARDE patients with high myopia, as was found in ARDE patients without high myopia. The LR angle might be useful for judging the degree of LR pulley displacement.
en-copyright=
kn-copyright=

en-aut-name=KonoReika
en-aut-sei=Kono
en-aut-mei=Reika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhtsukiHiroshi
en-aut-sei=Ohtsuki
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KishimotoFumiko
en-aut-sei=Kishimoto
en-aut-mei=Fumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HamasakiIchiro
en-aut-sei=Hamasaki
en-aut-mei=Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MorizaneYuki
en-aut-sei=Morizane
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShiragaFumio
en-aut-sei=Shiraga
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Ophthalmology, Medical School, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Ophthalmology, Okayama Saiseikai General Hospital
kn-affil=

affil-num=3
en-affil=Division of Ophthalmology, Ibara City Hospital
kn-affil=

affil-num=4
en-affil=Department of Ophthalmology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=
en-keyword=age-related distance esotropia
kn-keyword=age-related distance esotropia
en-keyword=esotropia
kn-keyword=esotropia
en-keyword=high myopia
kn-keyword=high myopia
en-keyword=orbital pulley
kn-keyword=orbital pulley
en-keyword=sagging eye syndrome
kn-keyword=sagging eye syndrome
END

start-ver=1.4
cd-journal=joma
no-vol=65
cd-vols=
no-issue=3
article-no=
start-page=87
end-page=91
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of acquired haemophilia A with epistaxis
kn-title=鼻出血を契機に判明した後天性血友病 A の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=後天性血友病 A とは、凝固第�[因子に対する自己抗体が出現し出血症状を呈する疾患である。われわれは鼻出血を契機に発見された後天性血友病 A の 1 例を経験した。症例は 73 歳、男性。鼻出血を繰り返し、当科を受診した。出血点を認め焼灼するも再出血した。APTT 延長を認めたため当院血液内科に紹介し、後天性血友病と診断され現在治療中であり、治療開始後は再出血なく経過している。後天性血友病の初発症状は、皮下や筋肉内の出血が多く、鼻出血を契機に発見された症例はまれである。比較的まれな疾患ではあるが、診断が遅れれば、頭蓋内出血や腹腔内出血といった致死的な出血を来す可能性がある。早期診断・治療が重要であり、耳鼻咽喉科医も知識を有しておくべき疾患である。
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=秋定直樹
kn-aut-sei=秋定
kn-aut-mei=直樹
aut-affil-num=1
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=2
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=竹内彩子
kn-aut-sei=竹内
kn-aut-mei=彩子
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=藤澤郁
kn-aut-sei=藤澤
kn-aut-mei=郁
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=赤木成子
kn-aut-sei=赤木
kn-aut-mei=成子
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=2
en-affil=
kn-affil=岡山赤十字病院耳鼻咽喉科 

affil-num=3
en-affil=
kn-affil=岡山赤十字病院耳鼻咽喉科 

affil-num=4
en-affil=
kn-affil=岡山赤十字病院耳鼻咽喉科

affil-num=5
en-affil=
kn-affil=岡山赤十字病院耳鼻咽喉科
en-keyword=鼻出血
kn-keyword=鼻出血
en-keyword=後天性血友病
kn-keyword=後天性血友病
en-keyword=凝固第�[因子
kn-keyword=凝固第�[因子
en-keyword=第�[因子インヒビター
kn-keyword=第�[因子インヒビター
en-keyword=出血性疾患	
kn-keyword=出血性疾患	
END

start-ver=1.4
cd-journal=joma
no-vol=61
cd-vols=
no-issue=3
article-no=
start-page=470
end-page=480
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191113
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Regulation of the Poly(A) Status of Mitochondrial mRNA by Poly(A)-Specific Ribonuclease Is Conserved among Land Plants
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Regulation of the stability and the quality of mitochondrial RNA is essential for the maintenance of mitochondrial and cellular functions in eukaryotes. We have previously reported that the eukaryotic poly(A)-specific ribonuclease (PARN) and the prokaryotic poly(A) polymerase encoded by AHG2 and AGS1, respectively, coordinately regulate the poly(A) status and the stability of mitochondrial mRNA in Arabidopsis. Mitochondrial function of PARN has not been reported in any other eukaryotes. To know how much this PARN-based mitochondrial mRNA regulation is conserved among plants, we studied the AHG2 and AGS1 counterparts of the liverwort, Marchantia polymorpha, a member of basal land plant lineage. We found that M. polymorpha has one ortholog each for AHG2 and AGS1, named MpAHG2 and MpAGS1, respectively. Their Citrine-fused proteins were detected in mitochondria of the liverwort. Molecular genetic analysis showed that MpAHG2 is essential and functionally interacts with MpAGS1 as observed in Arabidopsis. A recombinant MpAHG2 protein had a deadenylase activity in vitro. Overexpression of MpAGS1 and the reduced expression of MpAHG2 caused an accumulation of polyadenylated Mpcox1 mRNA. Furthermore, MpAHG2 suppressed Arabidopsis ahg2-1 mutant phenotype. These results suggest that the PARN-based mitochondrial mRNA regulatory system is conserved in land plants.
en-copyright=
kn-copyright=

en-aut-name=KanazawaMai
en-aut-sei=Kanazawa
en-aut-mei=Mai
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IkedaYoko
en-aut-sei=Ikeda
en-aut-mei=Yoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NishihamaRyuichi
en-aut-sei=Nishihama
en-aut-mei=Ryuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YamaokaShohei
en-aut-sei=Yamaoka
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=LeeNam-Hee
en-aut-sei=Lee
en-aut-mei=Nam-Hee
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamatoKatsuyuki T
en-aut-sei=Yamato
en-aut-mei=Katsuyuki T
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KohchiTakayuk
en-aut-sei=Kohchi
en-aut-mei=Takayuk
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HirayamaTakashi
en-aut-sei=Hirayama
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Division of Science for Bioresources, Graduate School of Environment and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Science for Bioresources, Graduate School of Environment and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Biostudies, Kyoto University
kn-affil=

affil-num=4
en-affil=Graduate School of Biostudies, Kyoto University
kn-affil=

affil-num=5
en-affil=Department of Life Sciences, Faculty of Science and Engineering, Sorbonne University
kn-affil=

affil-num=6
en-affil=Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kindai University
kn-affil=

affil-num=7
en-affil=Graduate School of Biostudies, Kyoto University
kn-affil=

affil-num=8
en-affil=Division of Science for Bioresources, Graduate School of Environment and Life Science, Okayama University
kn-affil=
en-keyword=Arabidopsis
kn-keyword=Arabidopsis
en-keyword=Marchantia polymorpha
kn-keyword=Marchantia polymorpha
en-keyword=Mitochondria
kn-keyword=Mitochondria
en-keyword= Poly(A) polymerase
kn-keyword= Poly(A) polymerase
en-keyword=Poly(A) regulation
kn-keyword=Poly(A) regulation
en-keyword= Poly(A)-specific ribonuclease
kn-keyword= Poly(A)-specific ribonuclease
END

start-ver=1.4
cd-journal=joma
no-vol=223-225
cd-vols=
no-issue=
article-no=
start-page=72
end-page=78
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Quorum-dependent expression of rsmX and rsmY, small non-coding RNAs, in Pseudomonas syringae
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Pseudomonas syringae pathovars are known to produce N-acyl-homoserine lactones (AHL) as quorum-sensing molecules. However, many isolates, including P. syringae pv. tomato DC3000 (PtoDC3000), do not produce them. In P. syringae, psyI, which encodes an AHL synthase, and psyR, which encodes the transcription factor PsyR required for activation of psyI, are convergently transcribed. In P. amygdali pv. tabaci 6605 (Pta6605), there is one nucleotide between the stop codons of both psyI and psyR. However, the canonical stop codon for psyI in PtoDC3000 was converted to the cysteine codon by one nucleotide deletion, and 23 additional amino acids extended it to a C-terminal end. This resulted in overlapping of the open reading frame (ORF) for psyI and psyR. On the other hand, stop codons in the psyR ORF of P. syringae 7 isolates, including pv. phaseolicola and pv. glycinea, were found. These results indicate that many pathovars of P. syringae have genetically lost AHL production ability by the mutation of their responsible genes. To examine whether PtoDC3000 modulates the gene expression profile in a population-dependent manner, we carried out microarray analysis using RNAs prepared from low- and high-density cells. We found the expressions of rsmX and rsmY remarkably activated in high-density cells. The activated expressions of rsmX and rsmY were confirmed by Northern blot hybridization, but these expressions were abolished in a ΔgacA mutant of Pta6605. These results indicate that regardless of the ability to produce AHL, P. syringae regulates expression of the small noncoding RNAs rsmX/Y by currently unknown quorum-sensing molecules.
en-copyright=
kn-copyright=

en-aut-name=NakatsuYukiko
en-aut-sei=Nakatsu
en-aut-mei=Yukiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MatsuiHidenori
en-aut-sei=Matsui
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamamotoMikihiro
en-aut-sei=Yamamoto
en-aut-mei=Mikihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NoutoshiYoshiteru
en-aut-sei=Noutoshi
en-aut-mei=Yoshiteru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ToyodaKazuhiro
en-aut-sei=Toyoda
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IchinoseYuki
en-aut-sei=Ichinose
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=N-acyl-homoserine lactone
kn-keyword=N-acyl-homoserine lactone
en-keyword=Gac two-component system
kn-keyword=Gac two-component system
en-keyword=Quorum sensing
kn-keyword=Quorum sensing
en-keyword=rsmX
kn-keyword=rsmX
en-keyword=rsmY
kn-keyword=rsmY
en-keyword=Pseudomonas syringae
kn-keyword=Pseudomonas syringae
END

start-ver=1.4
cd-journal=joma
no-vol=141
cd-vols=
no-issue=25
article-no=
start-page=9832
end-page=9836
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019611
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Deoxygenative Insertion of Carbonyl Carbon into a C(sp3)?H Bond: Synthesis of Indolines and Indoles
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A simple deoxygenation reagent prepared in situ from commercially available Mo(CO)6 and ortho-quinone has been developed for the synthesis of indoline and indole derivatives. The Mo/quinone complex efficiently deoxygenates carbonyl compounds bearing a neighboring dialkylamino group and effects intramolecular cyclizations with the insertion of a deoxygenated carbonyl carbon into a C(sp3)?H bond, in which a carbonyl group acts as a carbene equivalent. The reaction also proceeds with a catalytic amount of Mo/quinone in the presence of disilane as an oxygen atom acceptor.
en-copyright=
kn-copyright=

en-aut-name=AsakoSobi
en-aut-sei=Asako
en-aut-mei=Sobi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshiharaSeina
en-aut-sei=Ishihara
en-aut-mei=Seina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HirataKeiya
en-aut-sei=Hirata
en-aut-mei=Keiya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakaiKazuhiko
en-aut-sei=Takai
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=C-H activation
kn-keyword=C-H activation
en-keyword=Oxidative addition
kn-keyword=Oxidative addition
en-keyword=Structural-characterization
kn-keyword=Structural-characterization
en-keyword=Ditungsten hexaalkoxides
kn-keyword=Ditungsten hexaalkoxides
en-keyword=Direct functionalization
kn-keyword=Direct functionalization
en-keyword=Organic-synthesis
kn-keyword=Organic-synthesis
en-keyword=Tertiary-amines
kn-keyword=Tertiary-amines
en-keyword=Oxo-alkylidene
kn-keyword=Oxo-alkylidene
en-keyword=Ketones
kn-keyword=Ketones
en-keyword=Chemistry
kn-keyword=Chemistry
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=17
article-no=
start-page=6756
end-page=6760
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190808
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Rhenium-Catalyzed Cyclization via 1,2-Iodine and 1,5-Hydrogen Migration for the Synthesis of 2-Iodo-1H-indenes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A rhenium complex catalyzed the formation of 2-iodo-1H-indene derivatives through iodine and hydrogen migration of 3-iodopropargyl ethers. The reaction proceeded via generation of 1-iodoalkenylrhenium carbene species by sequential 1,2-iodine and 1,5-hydrogen shifts with readily available precursors under neutral conditions. The reaction mechanism and the reactivity of the generated alkenylcarbene species were also investigated.
en-copyright=
kn-copyright=

en-aut-name=MuraiMasahito
en-aut-sei=Murai
en-aut-mei=Masahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakaiKazuhiko
en-aut-sei=Takai
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=anti-markovnikov addition
kn-keyword=anti-markovnikov addition
en-keyword=silyl enol ethers
kn-keyword=silyl enol ethers
en-keyword=terminal alkynes
kn-keyword=terminal alkynes
en-keyword=metal vinylidenes
kn-keyword=metal vinylidenes
en-keyword=cycloisomerization
kn-keyword=cycloisomerization
en-keyword=ruthenium
kn-keyword=ruthenium
en-keyword=complexes
kn-keyword=complexes
en-keyword=derivatives
kn-keyword=derivatives
en-keyword=carbene
kn-keyword=carbene
en-keyword=functionalization
kn-keyword=functionalization
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=9
article-no=
start-page=3441
end-page=3445
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190418
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Rhenium-Catalyzed Regioselective ortho-Alkenylation and [3 + 2 + 1] Cycloaddition of Phenols with Internal Alkynes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An operationally simple and direct rhenium-catalyzed ortho-alkenylation (C-alkenylation) of unprotected phenols with alkynes was developed. The protocol provided ortho-alkenylphenols exclusively, and formation of para- or multiply alkenylated phenols and hydrophenoxylation (O-alkenylation) products were not observed. The [3 + 2 + 1] cycloaddition of phenols and two alkynes via ortho-alkenylation was also demonstrated, in which the alkynes functioned as both two- and one-carbon units. These reactions proceeded with readily available starting materials under neutral conditions without additional ligands.
en-copyright=
kn-copyright=

en-aut-name=MuraiMasahito
en-aut-sei=Murai
en-aut-mei=Masahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoMasaki
en-aut-sei=Yamamoto
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakaiKazuhiko
en-aut-sei=Takai
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=anti-markovnikov addition
kn-keyword=anti-markovnikov addition
en-keyword=intramolecular hydroarylation
kn-keyword=intramolecular hydroarylation
en-keyword=oxidative annulation
kn-keyword=oxidative annulation
en-keyword=gold
kn-keyword=gold
en-keyword=hydrophenoxylation
kn-keyword=hydrophenoxylation
en-keyword=construction
kn-keyword=construction
en-keyword=cyclization
kn-keyword=cyclization
en-keyword=vinylation
kn-keyword=vinylation
en-keyword=alkenes
kn-keyword=alkenes
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=8
article-no=
start-page=2668
end-page=2672
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190404
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Chromium-Mediated Stannylcyclopropanation of Alkenes with (Diiodomethyl)stannanes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A stannyl-group-substituted gem-dichromiomethane species, generated in situ from CrCl2, TMEDA, and tributyl(diiodomethyl)stannane, worked as an efficient stannylcarbene equivalent to promote cyclopropanation of alkenes. The reaction provided synthetically useful stannylcyclopropanes directly from commercially available unactivated alkenes without using potentially flammable alkylzinc and diazo compounds. Structural characterization of stannyl- and germyl-group-substituted gem-dichromiomethane complexes and the effect of group 14 elements containing substituents for cyclopropanation are also described.
en-copyright=
kn-copyright=

en-aut-name=MuraiMasahito
en-aut-sei=Murai
en-aut-mei=Masahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TaniguchiRyuji 
en-aut-sei=Taniguchi
en-aut-mei=Ryuji 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MizutaChisato
en-aut-sei=Mizuta
en-aut-mei=Chisato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakaiKazuhiko
en-aut-sei=Takai
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=chromium(II)-mediate synthesis
kn-keyword=chromium(II)-mediate synthesis
en-keyword=stereoselective-synthesis
kn-keyword=stereoselective-synthesis
en-keyword=e-alkenylstannanes
kn-keyword=e-alkenylstannanes
en-keyword=redox system
kn-keyword=redox system
en-keyword=cyclopropanation
kn-keyword=cyclopropanation
en-keyword=aldehydes
kn-keyword=aldehydes
en-keyword=reagents
kn-keyword=reagents
en-keyword=cyclopropenes
kn-keyword=cyclopropenes
en-keyword=reactivity
kn-keyword=reactivity
en-keyword=reduction
kn-keyword=reduction
END

start-ver=1.4
cd-journal=joma
no-vol=25
cd-vols=
no-issue=66
article-no=
start-page=15189
end-page=15197
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190918
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mechanistic Insights into Rhenium-Catalyzed Regioselective C-Alkenylation of Phenols with Internal Alkynes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A (μ-aryloxo)rhenium complex was isolated and confirmed as a key precatalyst for rhenium-catalyzed ortho-alkenylation (C-alkenylation) of unprotected phenols with alkynes. The reaction exclusively provided ortho-alkenylphenols; the formation of para or multiply alkenylated phenols and hydrophenoxylation (O-alkenylation) products was not observed. Several mechanistic experiments excluded a classical Friedel-Crafts-type mechanism, leading to the proposed phenolic hydroxyl group assisted electrophilic alkenylation as the most plausible reaction mechanism. For this purpose, the use of rhenium, a metal between the early and late transition metals in the periodic table, was key for the activation of both the soft carbon-carbon triple bond of the alkyne and the hard oxygen atom of the phenol, at the same time. ortho-Selective alkenylation with allenes also provided the corresponding adducts with a substitution pattern different from that obtained by the addition reaction with alkynes.
en-copyright=
kn-copyright=

en-aut-name=MuraiMasahito
en-aut-sei=Murai
en-aut-mei=Masahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoMasaki
en-aut-sei=Yamamoto
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakaiKazuhiko
en-aut-sei=Takai
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=alkenylation
kn-keyword=alkenylation
en-keyword=homogeneous catalysis
kn-keyword=homogeneous catalysis
en-keyword=reaction mechanisms
kn-keyword=reaction mechanisms
en-keyword=regioselectivity
kn-keyword=regioselectivity
en-keyword=rhenium
kn-keyword=rhenium
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=1
article-no=
start-page=82
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191229
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Hematopoietic Cells Derived from Cancer Stem Cells Generated from Mouse Induced Pluripotent Stem Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cancer stem cells (CSCs) represent the subpopulation of cancer cells with the ability to differentiate into other cell phenotypes and initiated tumorigenesis. Previously, we reported generating CSCs from mouse induced pluripotent stem cells (miPSCs). Here, we investigated the ability of the CSCs to differentiate into hematopoietic cells. First, the primary cells were isolated from malignant tumors that were formed by the CSCs. Non-adherent cells (NACs) that arose from adherent cells were collected and their viability, as well as the morphology and expression of hematopoietic cell markers, were analyzed. Moreover, NACs were injected into the tail vein of busulfan conditioned Balb/c nude mice. Finally, CSCs were induced to differentiate to macrophages while using IL3 and SCF. The round nucleated NACs were found to be viable, positive for hematopoietic lineage markers and CD34, and expressed hematopoietic markers, just like homing to the bone marrow. When NACs were injected into mice, Wright-Giemsa staining showed that the number of white blood cells got higher than those in the control mice after four weeks. CSCs also showed the ability to differentiate toward macrophages. CSCs were demonstrated to have the potential to provide progenies with hematopoietic markers, morphology, and homing ability to the bone marrow, which could give new insight into the tumor microenvironment according to the plasticity of CSCs.
en-copyright=
kn-copyright=

en-aut-name=HassanGhmkin
en-aut-sei=Hassan
en-aut-mei=Ghmkin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AfifySaid M.
en-aut-sei=Afify
en-aut-mei=Said M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NairNeha
en-aut-sei=Nair
en-aut-mei=Neha
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KumonKazuki
en-aut-sei=Kumon
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OsmanAmira
en-aut-sei=Osman
en-aut-mei=Amira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=DuJuan
en-aut-sei=Du
en-aut-mei=Juan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MansourHager
en-aut-sei=Mansour
en-aut-mei=Hager
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=Abu QuoraHagar A.
en-aut-sei=Abu Quora
en-aut-mei=Hagar A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NawaraHend M.
en-aut-sei=Nawara
en-aut-mei=Hend M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SatohAyano
en-aut-sei=Satoh
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=ZahraMaram H.
en-aut-sei=Zahra
en-aut-mei=Maram H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=OkadaNobuhiro
en-aut-sei=Okada
en-aut-mei=Nobuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=SenoAkimasa
en-aut-sei=Seno
en-aut-mei=Akimasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SenoMasaharu
en-aut-sei=Seno
en-aut-mei=Masaharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=
kn-affil=Graduate School of Natural Science and Technology, Okayama University

affil-num=8
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=10
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=11
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=12
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=13
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=14
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=Induced pluripotent stem cells
kn-keyword=Induced pluripotent stem cells
en-keyword=Cancer stem cells differentiation
kn-keyword=Cancer stem cells differentiation
en-keyword=tumor microenvironment
kn-keyword=tumor microenvironment
en-keyword=hematopoietic cells
kn-keyword=hematopoietic cells
END

start-ver=1.4
cd-journal=joma
no-vol=68
cd-vols=
no-issue=1
article-no=
start-page=57
end-page=62
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190731
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objective: In lung transplantation (LTx) from donation after cardiac death (DCD), the donor lungs are inevitably exposed to warm ischemic time (WIT) between the cardiac arrest and the initiation of cold preservation. We conducted this study to examine the effect of prolonged WIT on lung allograft rejection in a murine model of LTx from DCD.<br/>
Methods: Allogeneic BALB/c → B6 LTx from DCD was performed with a WIT of 15 min (WIT15 group, n = 5) or 60 min (WIT60 group, n = 5). Recipients were immunosuppressed by perioperative costimulatory blockade. The lung allografts were analyzed by histology and flow cytometry on day 7 after the LTx.<br/>
Results: Histologically, the rejection grade in the WIT60 group was significantly higher than that in the WIT15 group (3.4 ± 0.4 vs. 2.2 ± 0.2, P = 0.0278). Moreover, the intragraft CD8+ to CD4+ T cell ratio in the WIT60 group was significantly higher than that in the WIT15 group (2.3 ± 0.12 vs. 1.2 ± 0.11, P < 0.0001).<br/>
Conclusions: Prolonged WIT could exacerbate the severity of lung allograft rejection after LTx from DCD. Minimization of the WIT could improve the outcomes after LTx from DCD.
en-copyright=
kn-copyright=

en-aut-name=HiranoYutaka
en-aut-sei=Hirano
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SugimotoSeiichiro
en-aut-sei=Sugimoto
en-aut-mei=Seiichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamamotoSumiharu
en-aut-sei=Yamamoto
en-aut-mei=Sumiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkadaMasanori
en-aut-sei=Okada
en-aut-mei=Masanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OtaniShinji
en-aut-sei=Otani
en-aut-mei=Shinji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OharaToshiaki
en-aut-sei=Ohara
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=YamaneMasaomi
en-aut-sei=Yamane
en-aut-mei=Masaomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatsukawaAkihiro
en-aut-sei=Matsukawa
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=OtoTakahiro
en-aut-sei=Oto
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Thoracic Surgery, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Organ Transplant Center, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Organ Transplant Center, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Brain dead donor
kn-keyword=Brain dead donor
en-keyword=Donation after cardiac death
kn-keyword=Donation after cardiac death
en-keyword=Lung transplantation
kn-keyword=Lung transplantation
en-keyword=Organ preservation
kn-keyword=Organ preservation
en-keyword=Rejection
kn-keyword=Rejection
END

start-ver=1.4
cd-journal=joma
no-vol=2180
cd-vols=
no-issue=
article-no=
start-page=020028
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Consideration to Display Operator Support Information to Human Operators under High Mental Pressure
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Operator support systems are extensively studied and developed to support human operators for their activities in especially an abnormal condition of a nuclear power plant. By the advancement of computer technology and artificial intelligence, an operator support system can provide detailed support information based on detailed models and utilizing detailed simulation of plant dynamics and/or complicated inference algorithms. However, human operators may not understand the detailed support information under high mental pressure in an abnormal plant condition. In such a case, it is important how to provide essential and understandable support information. This paper deals with a technique to simplify functional models in order to display operator support information that is generated based on detailed functional models. This paper defines eight cognitive states of human operators from the viewpoint of cognitive abilities of human. In addition, three ways to simplify functional models are identified.
en-copyright=
kn-copyright=

en-aut-name=GofukuAkio
en-aut-sei=Gofuku
en-aut-mei=Akio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=operator support system
kn-keyword=operator support system
en-keyword= information display
kn-keyword= information display
en-keyword=model simplification
kn-keyword=model simplification
en-keyword=cognitive state
kn-keyword=cognitive state
END

start-ver=1.4
cd-journal=joma
no-vol=59
cd-vols=
no-issue=3
article-no=
start-page=218
end-page=229
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191209
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Unlimited Potential of Microbial Rhodopsins as Optical Tools
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Microbial rhodopsins, a photoactive membrane protein family, serve as fundamental tools for optogenetics, an innovative technology for controlling biological activities with light. Microbial rhodopsins are widely distributed in nature and have a wide variety of biological functions. Regardless of the many different known types of microbial rhodopsins, only a few of them have been used in optogenetics to control neural activity to understand neural networks. The efforts of our group have been aimed at identifying and characterizing novel rhodopsins from nature and also at engineering novel variant rhodopsins by rational design. On the basis of the molecular and functional characteristics of those novel rhodopsins, we have proposed new rhodopsin-based optogenetics tools to control not only neural activities but also "non-neural" activities. In this Perspective, we introduce the achievements and summarize future challenges in creating optogenetics tools using rhodopsins. The implementation of optogenetics deep inside an in vivo brain is the well-known challenge for existing rhodopsins. As a perspective to address this challenge, we introduce innovative optical illumination techniques using wavefront shaping that can reinforce the low light sensitivity of the rhodopsins and realize deep-brain optogenetics. The applications of our optogenetics tools could be extended to manipulate non-neural biological activities such as gene expression, apoptosis, energy production, and muscle contraction. We also discuss the potentially unlimited biotechnological applications of microbial rhodopsins in the future such as in photovoltaic devices and in drug delivery systems. We believe that advances in the field will greatly expand the potential uses of microbial rhodopsins as optical tools.
en-copyright=
kn-copyright=

en-aut-name=KojimaKeiichi
en-aut-sei=Kojima
en-aut-mei=Keiichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShibukawaAtsushi
en-aut-sei=Shibukawa
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SudoYuki
en-aut-sei=Sudo
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University,
kn-affil=

affil-num=2
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University,
kn-affil=

affil-num=3
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=85
cd-vols=
no-issue=2
article-no=
start-page=798
end-page=805
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191218
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Formal Total Synthesis of Manzacidin B via Sequential Diastereodivergent Henry Reaction
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A formal total synthesis of manzacidin B is described. beta,beta-Disubstituted gamma-hydroxy-beta-aminoalcohol, the key structure of manzacidin B, is stereoselectively constructed via sequential Henry reactions. By taking advantage of noncovalent interactions, such as intramolecular hydrogen bonding and chelation, we could diastereodivergently control the stereoselectivity of the Henry reaction.
en-copyright=
kn-copyright=

en-aut-name=ArakiYuya
en-aut-sei=Araki
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyoshiNatsumi
en-aut-sei=Miyoshi
en-aut-mei=Natsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MorimotoKazuki
en-aut-sei=Morimoto
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KudohTakayuki
en-aut-sei=Kudoh
en-aut-mei=Takayuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MizoguchiHaruki
en-aut-sei=Mizoguchi
en-aut-mei=Haruki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SakakuraAkira
en-aut-sei=Sakakura
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=裏表紙・英文目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=39
end-page=52
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=All Began with White : Paul Auster and His Thelxinoe
kn-title=すべては白から始まった : Paul Austerを魅惑するミューズ、テルクシノエー
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakataniHitomi
en-aut-sei=Nakatani
en-aut-mei=Hitomi
kn-aut-name=中谷ひとみ
kn-aut-sei=中谷
kn-aut-mei=ひとみ
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=29
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A.Tatarinov ”Lexicon” Notes 9（Ц〜Я）
kn-title=Ａ．タタリノフ『レクシコン』注釈９（Ц〜Я）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=EguchiYasuo
en-aut-sei=Eguchi
en-aut-mei=Yasuo
kn-aut-name=江口泰生
kn-aut-sei=江口
kn-aut-mei=泰生
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=13
end-page=28
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Hiroshima Dialect across the Sea : Inheritance and Change in a Japanese Dialect in Overseas Japanese Immigrant Communities
kn-title=海を渡った広島方言 : 海外日系移民社会における方言の継承と変容
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NakatoYasue
en-aut-sei=Nakato
en-aut-mei=Yasue
kn-aut-name=中東靖恵
kn-aut-sei=中東
kn-aut-mei=靖恵
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=1
end-page=12
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=On Suspicion as a Kind of Possibility
kn-title=可能性としての〈疑い〉
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MIYAZAKIKazuhito
en-aut-sei=MIYAZAKI
en-aut-mei=Kazuhito
kn-aut-name=宮崎和人
kn-aut-sei=宮崎
kn-aut-mei=和人
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Humanities and Social Sciences, Okayama University
kn-affil=岡山大学大学院社会文化科学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙・目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=111
cd-vols=
no-issue=3
article-no=
start-page=849
end-page=856
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191219
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=YES1 activation induces acquired resistance to neratinib in HER2-amplified breast and lung cancers
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Molecular-targeted therapies directed against human epidermal growth factor receptor 2 (HER2) are evolving for various cancers. Neratinib is an irreversible pan-HER tyrosine kinase inhibitor and has been approved by the FDA as an effective drug for HER2-positive breast cancer. However, acquired resistance of various cancers to molecular-targeted drugs is an issue of clinical concern, and emergence of resistance to neratinib is also considered inevitable. In this study, we established various types of neratinib-resistant cell lines from HER2-amplified breast and lung cancer cell lines using several drug exposure conditions. We analyzed the mechanisms of emergence of the resistance in these cell lines and explored effective strategies to overcome the resistance. Our results revealed that amplification of YES1, which is a member of the SRC family, was amplified in two neratinib-resistant breast cancer cell lines and one lung cancer cell line. Knockdown of YES1 by siRNA and pharmacological inhibition of YES1 by dasatinib restored the sensitivity of the YES1-amplified cell lines to neratinib in vitro. Combined treatment with dasatinib and neratinib inhibited tumor growth in vivo. This combination also induced downregulation of signaling molecules such as HER2, AKT and MAPK. Our current results indicate that YES1 plays an important role in the emergence of resistance to HER2-targeted drugs, and that dasatinib enables such acquired resistance to neratinib to be overcome.
en-copyright=
kn-copyright=

en-aut-name=TakedaTatsuaki
en-aut-sei=Takeda
en-aut-mei=Tatsuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamamotoHiromasa
en-aut-sei=Yamamoto
en-aut-mei=Hiromasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzawaKen
en-aut-sei=Suzawa
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TomidaShuta
en-aut-sei=Tomida
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MiyauchiShunsaku
en-aut-sei=Miyauchi
en-aut-mei=Shunsaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ArakiKota
en-aut-sei=Araki
en-aut-mei=Kota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakataKentaro
en-aut-sei=Nakata
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MiuraAkihiro
en-aut-sei=Miura
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NambaKei
en-aut-sei=Namba
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ShienKazuhiko
en-aut-sei=Shien
en-aut-mei=Kazuhiko
kn-aut-name=\
kn-aut-sei=
kn-aut-mei=\
aut-affil-num=10
ORCID=

en-aut-name=SohJunichi
en-aut-sei=Soh
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=ShienTadahiko
en-aut-sei=Shien
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=15
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=breast cancer
kn-keyword=breast cancer
en-keyword=drug resistance
kn-keyword=drug resistance
en-keyword=lung cancer
kn-keyword=lung cancer
en-keyword=neratinib
kn-keyword=neratinib
en-keyword=YES1
kn-keyword=YES1
END

start-ver=1.4
cd-journal=joma
no-vol=11
cd-vols=
no-issue=2
article-no=
start-page=97
end-page=104
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190916
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The hypoglycemia-prevention effect of sensor-augmented pump therapy with predictive low glucose management in Japanese patients with type 1 diabetes mellitus: a short-term study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aims/introduction</br>
The predictive low glucose management (PLGM) system was introduced in March 2018 in Japan. Although there are some reports demonstrating the benefit of PLGM in preventing hypoglycemia, no data are currently available in Japanese patients with type 1 diabetes mellitus (T1DM). The aim of the present study is to evaluate the effect of PLGM with sensor-augmented pump therapy in the prevention of hypoglycemia in Japanese patients.</br>
Materials and methods</br>
We included 16 patients with T1DM who used the MiniMed?640G system after switching from the MiniMed?620G system. We retrospectively analysed the data of the continuous glucose monitoring system in 1 month after switching to MiniMed?640G.</br>
Results</br>
The area under the curve (AUC) of hypoglycemia of?<?70 mg/dL was lowered from 0.42?±?0.43 mg/dL day to 0.18?±?0.18 mg/dL day (P?=?0.012). Correspondingly, the duration of severe hypoglycemia (<?54 mg/dL) was reduced significantly from 15.3?±?21.7 min/day to 4.8?±?6.9 min/day (P?=?0.019). The duration of hypoglycemia was reduced, but the reduction was not significant. Regarding the AUC for hyperglycemia?>?180 mg/dL and the duration of hyperglycemia did not change. With the PLGM function, 79.3% of the predicted hypoglycemic events were avoided.</br>
Conclusions</br>
The hypoglycemia avoidance rate was comparable to those in previous reports. In addition, we demonstrated that PLGM can markedly suppress severe hypoglycemia without deteriorating glycemic control in Japanese T1DM patients. It is necessary to further investigate the effective use of the PLGM feature such as establishing a lower limit and the timing of resumption.
en-copyright=
kn-copyright=

en-aut-name=KatayamaAkihiro
en-aut-sei=Katayama
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ToneAtsuhito
en-aut-sei=Tone
en-aut-mei=Atsuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WatanabeMayu
en-aut-sei=Watanabe
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TeshigawaraSanae
en-aut-sei=Teshigawara
en-aut-mei=Sanae
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MiyamotoSatoshi
en-aut-sei=Miyamoto
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=EguchiJun
en-aut-sei=Eguchi
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakatsukaAtsuko
en-aut-sei=Nakatsuka
en-aut-mei=Atsuko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ShikataKenichi
en-aut-sei=Shikata
en-aut-mei=Kenichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=WadaJun
en-aut-sei=Wada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Diabetes Center, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Diabetes Center, Okayama Saiseikai General Hospital
kn-affil=

affil-num=3
en-affil=Department of Primary Care and Medical Education, Okayama University
kn-affil=

affil-num=4
en-affil=Diabetes Center, Okayama Saiseikai General Hospital
kn-affil=

affil-num=5
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Okayama Univ, Dept Med & Clin Sci, Grad Sch Med Dent & Pharmaceut Sci
kn-affil=

affil-num=8
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Hypoglycemia
kn-keyword=Hypoglycemia
en-keyword=Predictive low glucose management (PLGM)
kn-keyword=Predictive low glucose management (PLGM)
en-keyword=Type 1 diabetes mellitus (T1DM)
kn-keyword=Type 1 diabetes mellitus (T1DM)
en-keyword=Sensor-augmented pump therapy (SAP)
kn-keyword=Sensor-augmented pump therapy (SAP)
END

start-ver=1.4
cd-journal=joma
no-vol=65
cd-vols=
no-issue=
article-no=
start-page=143
end-page=153
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191023
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of CYP3A5*3 genetic variant on the metabolism of direct-acting antivirals in vitro : a different effect on asunaprevir versus daclatasvir and beclabuvir
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Direct-acting antivirals, asunaprevir (ASV), daclatasvir (DCV), and beclabuvir (BCV) are known to be mainly metabolized by CYP3A enzymes; however, the differences in the detailed metabolic activities of CYP3A4 and CYP3A5 on these drugs are not well clarified. The aim of the present study was to elucidate the relative contributions of CYP3A4 and CYP3A5 to the metabolism of ASV, DCV, and BCV, as well as the effect of CYP3A5*3 genetic variant in vitro. The amount of each drug and their major metabolites were determined using LC-MS/MS. Recombinant CYP3As and CYP3A5*3-genotyped human liver microsomes (CYP3A5 expressers or non-expressers) were used for the determination of their metabolic activities. The contribution of CYP3A5 to ASV metabolism was considerable compared to that of CYP3A4. Consistently, ASV metabolic activity in CYP3A5 expressers was higher than those in CYP3A5 non-expresser. Moreover, CYP3A5 expression level was significantly correlated with ASV metabolism. In contrast, these observations were not found in DCV and BCV metabolism. To our knowledge, this is the first study to directly demonstrate the effect of CYP3A5*3 genetic variants on the metabolism of ASV. The findings of the present study may provide basic information on ASV, DCV, and BCV metabolisms.
en-copyright=
kn-copyright=

en-aut-name=MatsumotoJun
en-aut-sei=Matsumoto
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SanSu Nwe
en-aut-sei=San
en-aut-mei=Su Nwe
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=FujiyoshiMasachika
en-aut-sei=Fujiyoshi
en-aut-mei=Masachika
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawauchiAyano
en-aut-sei=Kawauchi
en-aut-mei=Ayano
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ChibaNatsumi
en-aut-sei=Chiba
en-aut-mei=Natsumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TagaiRan
en-aut-sei=Tagai
en-aut-mei=Ran
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SanbeRyoko
en-aut-sei=Sanbe
en-aut-mei=Ryoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YanakaShiho
en-aut-sei=Yanaka
en-aut-mei=Shiho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SakaueHiroaki
en-aut-sei=Sakaue
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KatoYoshinori
en-aut-sei=Kato
en-aut-mei=Yoshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=NakamuraHiroyoshi
en-aut-sei=Nakamura
en-aut-mei=Hiroyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=YamadaHarumi
en-aut-sei=Yamada
en-aut-mei=Harumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=AriyoshiNoritaka
en-aut-sei=Ariyoshi
en-aut-mei=Noritaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate
kn-affil=

affil-num=2
en-affil=Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare
kn-affil=

affil-num=3
en-affil=Department of Personalized Medicine and Preventive Healthcare Sciences, Graduate
kn-affil=

affil-num=4
en-affil=Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare
kn-affil=

affil-num=5
en-affil=Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare
kn-affil=

affil-num=6
en-affil=Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare
kn-affil=

affil-num=7
en-affil=Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare
kn-affil=

affil-num=8
en-affil=Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare
kn-affil=

affil-num=9
en-affil=Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
kn-affil=

affil-num=10
en-affil=Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare
kn-affil=

affil-num=11
en-affil=Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare
kn-affil=

affil-num=12
en-affil=Department of Pharmacokinetics, Pharmaceutical Sciences, International University of Health and Welfare
kn-affil=

affil-num=13
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama University
kn-affil=
en-keyword=Genetic markers
kn-keyword=Genetic markers
en-keyword=Haplotypes
kn-keyword=Haplotypes
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=171
end-page=172
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 84th Annual Meeting of the Japanese Society of Balneology, Climatology and Physical Medicine (BCPM)
kn-title=第84回日本温泉気候物理医学会総会・学術集会報告
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=光延文裕
kn-aut-sei=光延
kn-aut-mei=文裕
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Geriatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　老年医学
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=169
end-page=170
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=医療法人社団重仁　まるがめ医療センター
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=鎌野周平
kn-aut-sei=鎌野
kn-aut-mei=周平
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=165
end-page=167
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Reforming the way doctors work
kn-title=医師の働き方改革
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HamadaJun
en-aut-sei=Hamada
en-aut-mei=Jun
kn-aut-name=浜田淳
kn-aut-sei=浜田
kn-aut-mei=淳
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Health Economics and Policy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　医療政策・医療経済学
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=161
end-page=164
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Drug interaction（46. Blending change and interaction of an injection drug）
kn-title=薬物相互作用（46―注射薬の配合変化 : 注射薬の物理的・化学的な相互作用）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=MorishitaYosuke
en-aut-sei=Morishita
en-aut-mei=Yosuke
kn-aut-name=森下陽介
kn-aut-sei=森下
kn-aut-mei=陽介
aut-affil-num=1
ORCID=

en-aut-name=EsumiSatoru
en-aut-sei=Esumi
en-aut-mei=Satoru
kn-aut-name=江角悟
kn-aut-sei=江角
kn-aut-mei=悟
aut-affil-num=2
ORCID=

en-aut-name=NishiharaShigeki
en-aut-sei=Nishihara
en-aut-mei=Shigeki
kn-aut-name=西原茂樹
kn-aut-sei=西原
kn-aut-mei=茂樹
aut-affil-num=3
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=北村佳久
kn-aut-sei=北村
kn-aut-mei=佳久
aut-affil-num=4
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=千堂年昭
kn-aut-sei=千堂
kn-aut-mei=年昭
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=岡山大学病院　薬剤部

affil-num=2
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=岡山大学病院　薬剤部

affil-num=3
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=岡山大学病院　薬剤部

affil-num=4
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=岡山大学病院　薬剤部

affil-num=5
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=岡山大学病院　薬剤部
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=159
end-page=160
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Revision of the postgraduate clinical training system
kn-title=2020年度からの医師臨床研修制度の 改正について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SatoAsuka
en-aut-sei=Sato
en-aut-mei=Asuka
kn-aut-name=佐藤明香
kn-aut-sei=佐藤
kn-aut-mei=明香
aut-affil-num=1
ORCID=

en-aut-name=OgawaHiroko
en-aut-sei=Ogawa
en-aut-mei=Hiroko
kn-aut-name=小川弘子
kn-aut-sei=小川
kn-aut-mei=弘子
aut-affil-num=2
ORCID=

en-aut-name=MiyoshiTomoko
en-aut-sei=Miyoshi
en-aut-mei=Tomoko
kn-aut-name=三好智子
kn-aut-sei=三好
kn-aut-mei=智子
aut-affil-num=3
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=大塚文男
kn-aut-sei=大塚
kn-aut-mei=文男
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Center for Graduate Medical Education, Okayama University Hospital
kn-affil=岡山大学病院　卒後臨床研修センター

affil-num=2
en-affil=Center for Graduate Medical Education, Okayama University Hospital
kn-affil=岡山大学病院　卒後臨床研修センター

affil-num=3
en-affil=Center for Graduate Medical Education, Okayama University Hospital
kn-affil=岡山大学病院　卒後臨床研修センター

affil-num=4
en-affil=Center for Graduate Medical Education, Okayama University Hospital
kn-affil=岡山大学病院　卒後臨床研修センター
en-keyword=医師臨床研修制度 (postgraduate clinical training system)
kn-keyword=医師臨床研修制度 (postgraduate clinical training system)
en-keyword=研修医 (resident)
kn-keyword=研修医 (resident)
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=153
end-page=157
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hereditary colorectal cancer in clinical practice, in coordination with a patients’ association
kn-title=患者会と共に展開する遺伝性大腸癌の医療
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TanakayaKohjiKohji
en-aut-sei=TanakayaKohji
en-aut-mei=Kohji
kn-aut-name=田中屋宏爾
kn-aut-sei=田中屋
kn-aut-mei=宏爾
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of surgery, Division of cancer genome-based diagnostic and treatment, National hospital organization, Iwakuni clinical center
kn-affil=国立病院機構岩国医療センター　外科, がんゲノム診療部
en-keyword=患者会
kn-keyword=患者会
en-keyword=遺伝性大腸癌
kn-keyword=遺伝性大腸癌
en-keyword=リンチ症候群
kn-keyword=リンチ症候群
en-keyword=家族性大腸腺腫症
kn-keyword=家族性大腸腺腫症
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=145
end-page=152
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Emergency medical treatment of patients undergoing otolaryngology in the southeastern part of Okayama Prefecture
kn-title=岡山県南東部における夜間・休日の耳鼻咽喉科救急診療の実状
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To clarify the scenario regarding the emergency medical treatment of patients undergoing otolaryngology in southeastern Okayama Prefecture in Japan, we evaluated the conditions in three hospitals that mainly provide emergency medical treatment to patients undergoing otorhinolaryngology at night or on holidays. The data (age, sex, type of disease, and address) of patients who visited Japanese Red Cross Okayama Hospital, Kawasaki Medical School General Medical Center, and Okayama Medical Center in 2018 were collected and compared. All three hospitals reported many cases of tonsillar abscess and nasal bleeding. In the study population, the number of patients aged ?10 and 10-20 years were the lowest and highest, respectively. Patients residing in southern Okayama City and Tamano City tended to visit Japanese Red Cross Okayama Hospital or Kawasaki Medical School General Medical Center. Patients residing in northeastern Okayama Prefecture and northern Okayama City tended to visit Okayama Medical Center. A ceiling for the senior physicians’ capacity will be introduced in April 2020, and thus the number of otolaryngology-related treatments performed in Okayama Prefecture is expected to decrease. The otolaryngologyrelated emergency medical treatment in southeastern Okayama Prefecture may collapse. Emergency medical care systems must therefore be considered in the future.
en-copyright=
kn-copyright=

en-aut-name=AkisadaNaoki
en-aut-sei=Akisada
en-aut-mei=Naoki
kn-aut-name=秋定直樹
kn-aut-sei=秋定
kn-aut-mei=直樹
aut-affil-num=1
ORCID=

en-aut-name=IshiharaHisashi
en-aut-sei=Ishihara
en-aut-mei=Hisashi
kn-aut-name=石原久司
kn-aut-sei=石原
kn-aut-mei=久司
aut-affil-num=2
ORCID=

en-aut-name=UnoMasako
en-aut-sei=Uno
en-aut-mei=Masako
kn-aut-name=宇野雅子
kn-aut-sei=宇野
kn-aut-mei=雅子
aut-affil-num=3
ORCID=

en-aut-name=AkagiYusuke
en-aut-sei=Akagi
en-aut-mei=Yusuke
kn-aut-name=赤木祐介
kn-aut-sei=赤木
kn-aut-mei=祐介
aut-affil-num=4
ORCID=

en-aut-name=KajiwaraSohei
en-aut-sei=Kajiwara
en-aut-mei=Sohei
kn-aut-name=梶原壮平
kn-aut-sei=梶原
kn-aut-mei=壮平
aut-affil-num=5
ORCID=

en-aut-name=FukumotoAki
en-aut-sei=Fukumoto
en-aut-mei=Aki
kn-aut-name=福本晶
kn-aut-sei=福本
kn-aut-mei=晶
aut-affil-num=6
ORCID=

en-aut-name=WakabayashiTokio
en-aut-sei=Wakabayashi
en-aut-mei=Tokio
kn-aut-name=若林時生
kn-aut-sei=若林
kn-aut-mei=時生
aut-affil-num=7
ORCID=

en-aut-name=TakeuchiAyako
en-aut-sei=Takeuchi
en-aut-mei=Ayako
kn-aut-name=竹内彩子
kn-aut-sei=竹内
kn-aut-mei=彩子
aut-affil-num=8
ORCID=

en-aut-name=AkisadaTakeshi
en-aut-sei=Akisada
en-aut-mei=Takeshi
kn-aut-name=秋定健
kn-aut-sei=秋定
kn-aut-mei=健
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital, Department of Head and Neck Surgery, Shikoku Cancer Center
kn-affil=岡山赤十字病院　耳鼻咽喉科, 国立病院機構四国がんセンター　頭頸科

affil-num=2
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科

affil-num=3
en-affil=Department of Otolaryngology, Kawasaki Medical School General Medical Center
kn-affil=川崎医科大学総合医療センター　耳鼻咽喉科

affil-num=4
en-affil=Department of Otolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター　耳鼻咽喉科

affil-num=5
en-affil=Department of Otolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター　耳鼻咽喉科

affil-num=6
en-affil=Department of Otolaryngology, Okayama Medical Center
kn-affil=国立病院機構岡山医療センター　耳鼻咽喉科

affil-num=7
en-affil=Department of Otolaryngology, Kawasaki Medical School Hospital
kn-affil=川崎医科大学附属病院　耳鼻咽喉科

affil-num=8
en-affil=Department of Otolaryngology, Japanese Red Cross Okayama Hospital
kn-affil=岡山赤十字病院　耳鼻咽喉科

affil-num=9
en-affil=Department of Otolaryngology, Kawasaki Medical School General Medical Center
kn-affil=川崎医科大学総合医療センター　耳鼻咽喉科
en-keyword=耳鼻咽喉科 (otolaryngology)
kn-keyword=耳鼻咽喉科 (otolaryngology)
en-keyword=救急体制 (emergency system)
kn-keyword=救急体制 (emergency system)
en-keyword=働き方改革 (work style reform)
kn-keyword=働き方改革 (work style reform)
en-keyword=専門医制度 (specialist system)
kn-keyword=専門医制度 (specialist system)
en-keyword=地域医療 (regional medical care)
kn-keyword=地域医療 (regional medical care)
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=139
end-page=143
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Efficacy of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) or PPI plus a prokinetic in H. pylori-positive patients with dyspepsia
kn-title=ディスペプシア症状を訴えるヘリコバクター・ピロリ感染胃炎に対する除菌治療と，プロトンポンプ阻害剤，消化管運動機能改善剤の組み合わせ治療による症状改善効果の検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To investigate whether treatment comprised of Helicobacter pylori eradication followed by the administration of a proton pump inhibitor (PPI) alone and a dual treatment with a PPI plus a prokinetic agent helps relieve symptoms, we treated 26 patients with H. pylori infection and dyspepsia with the sequential treatment and assessed their symptoms. Scores for gastroesophageal reflux disease (GERD) and dyspepsia in a modified F-scale were significantly improved after the eradication of H. pylori, and symptoms were completely relieved in 13 patients. The remaining 13 patients received 4-week treatment with the PPI rabeprazole, and their GERD scores significantly improved after the treatment. The symptoms of five patients completely disappeared ; the other eight patients required dual treatment with a PPI plus the prokinetic acotiamide. Early satiety tended to be relieved after the dual treatment, but the improvement was not significant. Thus, in patients with dyspepsia and an H. pylori infection, the H. pylori should be eradicated first. The administration of a PPI is useful in patients with GERD symptoms, and a PPI+ acotiamide may be beneficial for residual symptoms of early satiety.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=三浦公
kn-aut-sei=三浦
kn-aut-mei=公
aut-affil-num=1
ORCID=

en-aut-name=IwamuroMasaya
en-aut-sei=Iwamuro
en-aut-mei=Masaya
kn-aut-name=岩室雅也
kn-aut-sei=岩室
kn-aut-mei=雅也
aut-affil-num=2
ORCID=

en-aut-name=ToyokawaTatsuya
en-aut-sei=Toyokawa
en-aut-mei=Tatsuya
kn-aut-name=豊川達也
kn-aut-sei=豊川
kn-aut-mei=達也
aut-affil-num=3
ORCID=

en-aut-name=TakenakaRyuta
en-aut-sei=Takenaka
en-aut-mei=Ryuta
kn-aut-name=竹中龍太
kn-aut-sei=竹中
kn-aut-mei=龍太
aut-affil-num=4
ORCID=

en-aut-name=InoueMasafumi
en-aut-sei=Inoue
en-aut-mei=Masafumi
kn-aut-name=井上雅文
kn-aut-sei=井上
kn-aut-mei=雅文
aut-affil-num=5
ORCID=

en-aut-name=ItoMamoru
en-aut-sei=Ito
en-aut-mei=Mamoru
kn-aut-name=伊藤守
kn-aut-sei=伊藤
kn-aut-mei=守
aut-affil-num=6
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=岡田裕之
kn-aut-sei=岡田
kn-aut-mei=裕之
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Internal Medicine, Tsuyama Chuo Hospital
kn-affil=津山中央病院　内科

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Phamaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学

affil-num=3
en-affil=Department of Gastroenterology, Fukuyama Medical Center
kn-affil=福山医療センター　消化器内科

affil-num=4
en-affil=Department of Internal Medicine, Tsuyama Chuo Hospital
kn-affil=津山中央病院　内科

affil-num=5
en-affil=Department of Gastroenterology, Okayama Red Cross Hospital
kn-affil=岡山赤十字病院　消化器内科

affil-num=6
en-affil=Department of Internal Medicine, Okayama Saiseikai General Hospital
kn-affil=岡山済生会総合病院　内科

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Phamaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学
en-keyword= 機能性ディスペプシア (functional dyspepsia)
kn-keyword= 機能性ディスペプシア (functional dyspepsia)
en-keyword=ヘリコバクター・ピロリ (Helicobacter pylori)
kn-keyword=ヘリコバクター・ピロリ (Helicobacter pylori)
en-keyword=プロトンポンプ阻害剤 (proton pomp inhibitor)
kn-keyword=プロトンポンプ阻害剤 (proton pomp inhibitor)
en-keyword=消化管運動機能改善剤 (acotiamide)
kn-keyword=消化管運動機能改善剤 (acotiamide)
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=135
end-page=137
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2018 Incentive Award of the Okayama Medical Association in Neuroscience (2018 Niimi Prize)
kn-title=平成30年度岡山医学会賞 脳神経研究奨励賞（新見賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=EdamatsuMidori
en-aut-sei=Edamatsu
en-aut-mei=Midori
kn-aut-name=枝松緑
kn-aut-sei=枝松
kn-aut-mei=緑
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　分子医化学
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=131
end-page=133
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2018 Incentive Award of the Okayama Medical Association in General Medical Science (2018 Yuuki Prize)
kn-title=平成30年度岡山医学会賞 総合研究奨励賞（結城賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=GaoYuan
en-aut-sei=Gao
en-aut-mei=Yuan
kn-aut-name=高遠
kn-aut-sei=高
kn-aut-mei=遠
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　薬理学
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=127
end-page=130
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2018 Incentive Award of the Okayama Medical Association in Cancer Research (2018 Hayashibara Prize and Yamada Prize)
kn-title=平成30年度岡山医学会賞 がん研究奨励賞（林原賞・山田賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=KatoTakuya
en-aut-sei=Kato
en-aut-mei=Takuya
kn-aut-name=加藤卓也
kn-aut-sei=加藤
kn-aut-mei=卓也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
END

start-ver=1.4
cd-journal=joma
no-vol=131
cd-vols=
no-issue=3
article-no=
start-page=123
end-page=125
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The 2018 Incentive Award of the Okayama Medical Association in Cardiovascular and Pulmonary Research (2018 Sunada Prize)
kn-title=平成30年度岡山医学会賞 胸部・循環研究奨励賞（砂田賞）
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=UmebayashiRyoko
en-aut-sei=Umebayashi
en-aut-mei=Ryoko
kn-aut-name=梅林亮子
kn-aut-sei=梅林
kn-aut-mei=亮子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Hospital
kn-affil=岡山大学病院　腎臓・糖尿病・内分泌内科
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=1
article-no=
start-page=16
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191221
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Expression and Ion Transport Activity of Rice OsHKT1;1 Variants
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=OsHKT1;1 in rice, belongs to the high-affinity K+ Transporter family, has been found to be involved in salt tolerance. OsHKT1;1 in japonica rice (Nipponbare) produces mRNA variants, but their functions remain elusive. In salt tolerant rice, Pokkali, eight OsHKT1;1 variants (V1-V8) were identified in addition to the full-length OsHKT1;1 (FL) cDNA. Absolute quantification by qPCR revealed that accumulation of OsHKT1;1-FL mRNA is minor in contrast to that of OsHKT1;1-V1, -V2, -V4, and -V7 mRNAs, all of which are predominant in shoots, while only V1 and V7 mRNAs are predominant in roots. Two electrode voltage clamp (TEVC) experiments using Xenopus laevis oocytes revealed that oocytes-expressing OsHKT1;1-FL from Pokkali exhibited inward-rectified currents in the presence of 96 mM Na+ as reported previously. Further TEVC analyses indicated that six of eight OsHKT1;1 variants elicited currents in a Na+ or a K+ bath solution. OsHKT1;1-V6 exhibited a similar inward rectification to the FL protein. Contrastingly, however, the rests mediated bidirectional currents in both Na+ and K+ bath solutions. These data suggest possibilities that novel mechanisms regulating the transport activity of OsHKT1;1 might exist, and that OsHKT1;1 variants might also carry out distinct physiological roles either independently or in combination with OsHKT1;1-FL.
en-copyright=
kn-copyright=

en-aut-name=ImranShahin
en-aut-sei=Imran
en-aut-mei=Shahin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HorieTomoaki
en-aut-sei=Horie
en-aut-mei=Tomoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatsuharaMaki
en-aut-sei=Katsuhara
en-aut-mei=Maki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Applied Biology, Faculty of the Textile Science and Technology, Shinshu University
kn-affil=

affil-num=3
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=HKT
kn-keyword=HKT
en-keyword=rice
kn-keyword=rice
en-keyword=salt tolerance
kn-keyword=salt tolerance
en-keyword=Na+ transport
kn-keyword=Na+ transport
en-keyword=K+ transport
kn-keyword=K+ transport
en-keyword=mRNA variants
kn-keyword=mRNA variants
END

start-ver=1.4
cd-journal=joma
no-vol=798
cd-vols=
no-issue=
article-no=
start-page=134980
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191110
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Search for heavy neutrinos in pi > mu nu decay
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the present work of the PIENU experiment, heavy neutrinos were sought in pion decays pi(+) -> mu(+)nu at rest by examining the observed muon energy spectrum for extra peaks in addition to the expected peak for a light neutrino. No evidence for heavy neutrinos was observed. Upper limits were set on the neutrino mixing matrix vertical bar U-mu i vertical bar(2) in the neutrino mass region of 15.7-33.8 MeV/c(2), improving on previous results by an order of magnitude. (C) 2019 The Authors. Published by Elsevier B.V.
en-copyright=
kn-copyright=

en-aut-name=Aguilar-ArevaloA.
en-aut-sei=Aguilar-Arevalo
en-aut-mei=A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AokiM.
en-aut-sei=Aoki
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BlecherM.
en-aut-sei=Blecher
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=BrittonD.I.
en-aut-sei=Britton
en-aut-mei=D.I.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=vom BruchBruch, D.
en-aut-sei=vom Bruch
en-aut-mei=Bruch, D.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=BrymanD. A.
en-aut-sei=Bryman
en-aut-mei=D. A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ChenS.
en-aut-sei=Chen
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ComfortJ.
en-aut-sei=Comfort
en-aut-mei=J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=DoriaL.
en-aut-sei=Doria
en-aut-mei=L.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=Cuen-RochinS.
en-aut-sei=Cuen-Rochin
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=GumplingerP.
en-aut-sei=Gumplinger
en-aut-mei=P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HusseinA.
en-aut-sei=Hussein
en-aut-mei=A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=IgarashiY.
en-aut-sei=Igarashi
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=ItoS.
en-aut-sei=Ito
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KettellS. H.
en-aut-sei=Kettell
en-aut-mei=S. H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=KurchaninovL.
en-aut-sei=Kurchaninov
en-aut-mei=L.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=LittenbergL. S.
en-aut-sei=Littenberg
en-aut-mei=L. S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=MalbrunotC.
en-aut-sei=Malbrunot
en-aut-mei=C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=MischkeR. E.
en-aut-sei=Mischke
en-aut-mei=R. E.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=NumaoT.
en-aut-sei=Numao
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=ProtopopescuD.
en-aut-sei=Protopopescu
en-aut-mei=D.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=SherA.
en-aut-sei=Sher
en-aut-mei=A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=SullivanT.
en-aut-sei=Sullivan
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

en-aut-name=VavilovD.
en-aut-sei=Vavilov
en-aut-mei=D.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=24
ORCID=

affil-num=1
en-affil=Instituto de Ciencias Nucleares, Universidad Nacional Aut?noma de Mexico
kn-affil=

affil-num=2
en-affil=Graduate School of Science, Osaka University,
kn-affil=

affil-num=3
en-affil=Physics Department, Virginia Tech.
kn-affil=

affil-num=4
en-affil=School of Physics and Astronomy, University of Glasgow
kn-affil=

affil-num=5
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=

affil-num=6
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=

affil-num=7
en-affil=Department of Engineering Physics, Tsinghua University
kn-affil=

affil-num=8
en-affil=Physics Department, Arizona State University
kn-affil=

affil-num=9
en-affil=TRIUMF, 4004 Wesbrook Mall
kn-affil=

affil-num=10
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=

affil-num=11
en-affil=TRIUMF, 4004 Wesbrook Mall
kn-affil=

affil-num=12
en-affil=University of Northern British Columbia
kn-affil=

affil-num=13
en-affil=KEK
kn-affil=

affil-num=14
en-affil=Graduate School of Science, Osaka University
kn-affil=

affil-num=15
en-affil=Brookhaven National Laboratory
kn-affil=

affil-num=16
en-affil=TRIUMF, 4004 Wesbrook Mall
kn-affil=

affil-num=17
en-affil=Brookhaven National Laboratory
kn-affil=

affil-num=18
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=

affil-num=19
en-affil=TRIUMF, 4004 Wesbrook Mall
kn-affil=

affil-num=20
en-affil=TRIUMF, 4004 Wesbrook Mall
kn-affil=

affil-num=21
en-affil=School of Physics and Astronomy, University of Glasgow
kn-affil=

affil-num=22
en-affil=TRIUMF, 4004 Wesbrook Mall
kn-affil=

affil-num=23
en-affil=Department of Physics and Astronomy, University of British Columbia
kn-affil=

affil-num=24
en-affil=TRIUMF, 4004 Wesbrook Mall
kn-affil=
en-keyword=Pion decay
kn-keyword=Pion decay
en-keyword=Heavy neutrino
kn-keyword=Heavy neutrino
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=13
article-no=
start-page=2495
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190708
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=BACKGROUND/AIM:Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers.<br/>
METHODS:The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model.<br/>
RESULTS:A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 ?g/mL, respectively.<br/>
CONCLUSION:Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.
en-copyright=
kn-copyright=

en-aut-name=ZahraMaram Hussein
en-aut-sei=Zahra
en-aut-mei=Maram Hussein
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SalemTarek A. R.
en-aut-sei=Salem
en-aut-mei=Tarek A. R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=El-AaragBishoy
en-aut-sei=El-Aarag
en-aut-mei=Bishoy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YosriNermeen
en-aut-sei=Yosri
en-aut-mei=Nermeen
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=EL-GhlbanSamah
en-aut-sei=EL-Ghlban
en-aut-mei=Samah
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ZakiKholoud
en-aut-sei=Zaki
en-aut-mei=Kholoud
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MareiAmel H.
en-aut-sei=Marei
en-aut-mei=Amel H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=Abd El-WahedAida
en-aut-sei=Abd El-Wahed
en-aut-mei=Aida
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SaeedAamer
en-aut-sei=Saeed
en-aut-mei=Aamer
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KhatibAlfi
en-aut-sei=Khatib
en-aut-mei=Alfi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=AlAjmiMohamed F.
en-aut-sei=AlAjmi
en-aut-mei=Mohamed F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=ShathiliAbdulrahman M.
en-aut-sei=Shathili
en-aut-mei=Abdulrahman M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=XiaoJianbo
en-aut-sei=Xiao
en-aut-mei=Jianbo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=KhalifaShaden A. M.
en-aut-sei=Khalifa
en-aut-mei=Shaden A. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=El-SeediHesham R.
en-aut-sei=El-Seedi
en-aut-mei=Hesham R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biochemistry, College of Medicine, Qassim University
kn-affil=

affil-num=3
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=5
en-affil=Biochemistry Division, Chemistry Department, Faculty of Science, Menoufia University
kn-affil=

affil-num=6
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=7
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=8
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=9
en-affil=Department of Chemistry, Quaid-i-Azam University
kn-affil=

affil-num=10
en-affil=Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia
kn-affil=

affil-num=11
en-affil=Pharmacognosy Group, College of Pharmacy, King Saud University
kn-affil=

affil-num=12
en-affil=Al-Rayan Research and Innovation Center, Al-Rayan Colleges
kn-affil=

affil-num=13
en-affil=Institute of Chinese Medical Sciences, University of Macau
kn-affil=

affil-num=14
en-affil=Clinical Research Centre, Karolinska University Hospital
kn-affil=

affil-num=15
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
en-keyword=Alpinia zerumbet
kn-keyword=Alpinia zerumbet
en-keyword=5,6-dehydrokawain
kn-keyword=5,6-dehydrokawain
en-keyword=Ehrlich ascites carcinoma
kn-keyword=Ehrlich ascites carcinoma
en-keyword=anti-tumor
kn-keyword=anti-tumor
en-keyword=anti-oxidant
kn-keyword=anti-oxidant
END

start-ver=1.4
cd-journal=joma
no-vol=14
cd-vols=
no-issue=1
article-no=
start-page=e0207049
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190129
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mortality in trauma patients admitted during, before, and after national academic emergency medicine and trauma surgery meeting dates in Japan
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Annually, many physicians attend national academic meetings. While participating in these meetings can have a positive impact on daily medical practice, attendance may result in reduced medical staffing during the meeting dates. We sought to examine whether there were differences in mortality after trauma among patients admitted to the hospital during, before, and after meeting dates. Using the Japan Trauma Data Bank, we analyzed in-hospital mortality in patients with traumatic injury admitted to the hospital from 2004 to 2015 during the dates of two national academic meetings-the Japanese Association for Acute Medicine (JAAM) and the Japanese Association for the Surgery of Trauma (JAST). We compared the data with that of patients admitted with trauma during identical weekdays in the weeks before and after the meetings, respectively. We used multiple logistic regression analysis to compare outcomes among the three groups. A total of 7,491 patients were included in our analyses, with 2,481, 2,492, and 2,518 patients in the during, before, and after meeting dates groups, respectively; their mortality rates were 7.3%, 8.0%, and 8.5%, respectively. After adjusting for covariates, no significant differences in in-hospital mortality were found among the three groups (adjusted odds ratio [95% CI] of the before meeting dates and after meeting dates groups; 1.18 [0.89-1.56] and 1.23 [0.93-1.63], respectively, with the during meeting dates group as the reference category). No significant differences in in-hospital mortality were found among trauma patients admitted during, before, and after the JAAM and JAST meeting dates.
en-copyright=
kn-copyright=

en-aut-name=YumotoTetsuya
en-aut-sei=Yumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaitouHiromichi
en-aut-sei=Naitou
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IhoriyaHiromi
en-aut-sei=Ihoriya
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Human Ecology,Okayama University Graduate School of Environmental and Life Science
kn-affil=

affil-num=5
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=1
article-no=
start-page=65
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191106
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Association of Japan Coma Scale score on hospital arrival with in-hospital mortality among trauma patients
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=BACKGROUND:
The Japan Coma Scale (JCS) score has been widely used to assess patients' consciousness level in Japan. JCS scores are divided into four main categories: alert (0) and one-, two-, and three-digit codes based on an eye response test, each of which has three subcategories. The purpose of this study was to investigate the utility of the JCS score on hospital arrival in predicting outcomes among adult trauma patients.<br/>
METHODS:
Using the Japan Trauma Data Bank, we conducted a nationwide registry-based retrospective cohort study. Patients 16?years old or older directly transported from the trauma scene between January 2004 and December 2017 were included. Our primary outcome was in-hospital mortality. We examined outcome prediction accuracy based on area under the receiver operating characteristic curve (AUROC) and multiple logistic regression analysis with multiple imputation.<br/>
RESULTS:
A total of 222,540 subjects were included; their in-hospital mortality rate was 7.1% (n =?15,860). The 10-point scale JCS and the total sum of Glasgow Coma Scale (GCS) scores demonstrated similar performance, in which the AUROC (95% CIs) showed 0.874 (0.871-0.878) and 0.878 (0.874-0.881), respectively. Multiple logistic regression analysis revealed that the higher the JCS score, the higher the predictability of in-hospital death. When we focused on the simple four-point scale JCS score, the adjusted odds ratio (95% confidence intervals [CIs]) were 2.31 (2.12-2.45), 4.81 (4.42-5.24), and 27.88 (25.74-30.20) in the groups with one-digit, two-digit, and three-digit scores, respectively, with JCS of 0 as a reference category.<br/>
CONCLUSIONS:
JCS score on hospital arrival after trauma would be useful for predicting in-hospital mortality, similar to the GCS score.
en-copyright=
kn-copyright=

en-aut-name=YumotoTetsuya
en-aut-sei=Yumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaitouHiromichi
en-aut-sei=Naitou
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AokageToshiyuki
en-aut-sei=Aokage
en-aut-mei=Toshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujisakiNoritomo
en-aut-sei=Fujisaki
en-aut-mei=Noritomo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama
kn-affil=

affil-num=4
en-affil=Department of Geriatric Emergency Medicine, Okayama University Graduate School of Medicine,Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Glasgow coma scale
kn-keyword=Glasgow coma scale
en-keyword=Japan Coma Scale
kn-keyword=Japan Coma Scale
en-keyword=Mortality
kn-keyword=Mortality
en-keyword=Trauma
kn-keyword=Trauma
en-keyword=Traumatic brain injury
kn-keyword=Traumatic brain injury
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=24
article-no=
start-page=5130
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191216
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Geographical Differences and the National Meeting Effect in Patients with Out-of-Hospital Cardiac Arrests: A JCS-ReSS Study Report
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The "national meeting effect" refers to worse patient outcomes when medical professionals attend academic meetings and hospitals have reduced staffing. The aim of this study was to examine differences in outcomes of patients with out-of-hospital cardiac arrest (OHCA) admitted during, before, and after meeting days according to meeting location and considering regional variation of outcomes, which has not been investigated in previous studies. Using data from a nationwide, prospective, population-based, observational study in Japan, we analyzed adult OHCA patients who underwent resuscitation attempts between 2011 and 2015. Favorable one-month neurological outcomes were compared among patients admitted during the relevant annual meeting dates of three national scientific societies, those admitted on identical days the week before, and those one week after the meeting dates. We developed a multivariate logistic regression model after adjusting for confounding factors, including meeting location and regional variation (better vs. worse outcome areas), using the "during meeting days" group as the reference. A total of 40,849 patients were included in the study, with 14,490, 13,518, and 12,841 patients hospitalized during, before, and after meeting days, respectively. The rates of favorable neurological outcomes during, before, and after meeting days was 1.7, 1.6, and 1.8%, respectively. After adjusting for covariates, favorable neurological outcomes did not differ among the three groups (adjusted OR (95% CI) of the before and after meeting dates groups was 1.03 (0.83-1.28) and 1.01 (0.81-1.26), respectively. The "national meeting effect" did not exist in OHCA patients in Japan, even after comparing data during, before, and after meeting dates and considering meeting location and regional variation.
en-copyright=
kn-copyright=

en-aut-name=YumotoTetsuya
en-aut-sei=Yumoto
en-aut-mei=Tetsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NaitouHiromichi
en-aut-sei=Naitou
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TaharaYoshio
en-aut-sei=Tahara
en-aut-mei=Yoshio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YonemotoNaohiro
en-aut-sei=Yonemoto
en-aut-mei=Naohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NonogiHiroshi
en-aut-sei=Nonogi
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NagaoKen
en-aut-sei=Nagao
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=IkedaTakanori
en-aut-sei=Ikeda
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SatoNaoki
en-aut-sei=Sato
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TsutsuiHiroyuki
en-aut-sei=Tsutsui
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
kn-affil=

affil-num=5
en-affil=National Center of Neurology and Psychiatry
kn-affil=

affil-num=6
en-affil=Intensive Care Center, Shizuoka General Hospital
kn-affil=

affil-num=7
en-affil=Cardiovascular Center, Nihon University Hospital
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Medicine, Toho University Faculty of Medicine
kn-affil=

affil-num=9
en-affil=Cardiovascular Medicine, Kawaguchi Cardiovascular and Respiratory Hospital
kn-affil=

affil-num=10
en-affil=Department of Cardiovascular Medicine, Kyushu University Faculty of Medical Sciences
kn-affil=
en-keyword=out-of-hospital cardiac arrest
kn-keyword=out-of-hospital cardiac arrest
en-keyword=outcome
kn-keyword=outcome
en-keyword=national meeting
kn-keyword=national meeting
en-keyword=cardiopulmonary resuscitation
kn-keyword=cardiopulmonary resuscitation
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=5
article-no=
start-page=eaav9053
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190501
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Layer-specific activation of sensory input and predictive feedback in the human primary somatosensory cortex
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=When humans perceive a sensation, their brains integrate inputs from sensory receptors and process them based on their expectations. The mechanisms of this predictive coding in the human somatosensory system are not fully understood. We fill a basic gap in our understanding of the predictive processing of somatosensation by examining the layer-specific activity in sensory input and predictive feedback in the human primary somatosensory cortex (S1). We acquired submillimeter functional magnetic resonance imaging data at 7T (n = 10) during a task of perceived, predictable, and unpredictable touching sequences. We demonstrate that the sensory input from thalamic projects preferentially activates the middle layer, while the superficial and deep layers in S1 are more engaged for cortico-cortical predictive feedback input. These findings are pivotal to understanding the mechanisms of tactile prediction processing in the human somatosensory cortex.
en-copyright=
kn-copyright=

en-aut-name=YuYinghua
en-aut-sei=Yu
en-aut-mei=Yinghua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HuberLaurentius
en-aut-sei=Huber
en-aut-mei=Laurentius
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YangJiajia
en-aut-sei=Yang
en-aut-mei=Jiajia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=JangrawDavid C.
en-aut-sei=Jangraw
en-aut-mei=David C.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HandwerkerDaniel A.
en-aut-sei=Handwerker
en-aut-mei=Daniel A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MolfesePeter J.
en-aut-sei=Molfese
en-aut-mei=Peter J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ChenGang
en-aut-sei=Chen
en-aut-mei=Gang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=EjimaYoshimichi
en-aut-sei=Ejima
en-aut-mei=Yoshimichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=WuJinglong
en-aut-sei=Wu
en-aut-mei=Jinglong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=BandettiniPeter A.
en-aut-sei=Bandettini
en-aut-mei=Peter A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems,Okayama University
kn-affil=

affil-num=2
en-affil=Section on Functional Imaging Methods, National Institute of Mental Health
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems,Okayama University
kn-affil=

affil-num=4
en-affil=Section on Functional Imaging Methods, National Institute of Mental Health
kn-affil=

affil-num=5
en-affil=Section on Functional Imaging Methods, National Institute of Mental Health
kn-affil=

affil-num=6
en-affil=Section on Functional Imaging Methods, National Institute of Mental Health
kn-affil=

affil-num=7
en-affil=Scientific and Statistical Computing Core, National Institute of Mental Health
kn-affil=

affil-num=8
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems,Okayama University
kn-affil=

affil-num=9
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems,Okayama University
kn-affil=

affil-num=10
en-affil=Section on Functional Imaging Methods, National Institute of Mental Health
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=24
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191216
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Cancer Cell-Derived Granulocyte-Macrophage Colony-Stimulating Factor Is Dispensable for the Progression of 4T1 Murine Breast Cancer
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We previously reported that 4T1 murine breast cancer cells produce GM-CSF that up-regulates macrophage expression of several cancer promoting genes, including Mcp-1/Ccl2, Ccl17 and Rankl, suggesting a critical role of cancer cell-derived GM-CSF in cancer progression. Here, we attempted to define whether 4T1 cell-derived GM-CSF contributes to the expression of these genes by 4T1tumors, and their subsequent progression. Intraperitoneal injection of anti-GM-CSF neutralizing antibody did not decrease the expression of Mcp-1, Ccl17 or Rankl mRNA by 4T1 tumors. To further examine the role of cancer cell-derived GM-CSF, we generated GM-CSF-deficient 4T1 cells by using the Crisper-Cas9 system. As previously demonstrated, 4T1 cells are a mixture of cells and cloning of cells by itself significantly reduced tumor growth and lung metastasis. By contrast, GM-CSF-deficiency did not affect tumor growth, lung metastasis or the expression of these chemokine and cytokine genes in tumor tissues. By in-situ hybridization, the expression of Mcp-1 mRNA was detected in both F4/80-expressing and non-expressing cells in tumors of GM-CSF-deficient cells. These results indicate that cancer cell-derived GM-CSF is dispensable for the tuning of the 4T1 tumor microenvironment and the production of MCP-1, CCL17 or RANKL in the 4T1 tumor microenvironment is likely regulated by redundant mechanisms.
en-copyright=
kn-copyright=

en-aut-name=YoshimuraTeizo
en-aut-sei=Yoshimura
en-aut-mei=Teizo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraKaoru
en-aut-sei=Nakamura
en-aut-mei=Kaoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=LiChunning
en-aut-sei=Li
en-aut-mei=Chunning
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujisawaMasayoshi
en-aut-sei=Fujisawa
en-aut-mei=Masayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShiinaTsuyoshi
en-aut-sei=Shiina
en-aut-mei=Tsuyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ImamuraMayu
en-aut-sei=Imamura
en-aut-mei=Mayu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=LiTiantian
en-aut-sei=Li
en-aut-mei=Tiantian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MukaidaNaofumi
en-aut-sei=Mukaida
en-aut-mei=Naofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsukawaAkihiro
en-aut-sei=Matsukawa
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University
kn-affil=

affil-num=9
en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=macrophages
kn-keyword=macrophages
en-keyword=chemokines
kn-keyword=chemokines
en-keyword=cytokines
kn-keyword=cytokines
en-keyword=inflammation
kn-keyword=inflammation
en-keyword=tumor microenvironment
kn-keyword=tumor microenvironment
en-keyword=breast cancer
kn-keyword=breast cancer
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=8
article-no=
start-page=e02141
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201908
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Stroking hardness changes the perception of affective touch pleasantness across different skin sites
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Human unmyelinated tactile afferents (CT afferents) in hairy skin are thought to be involved in the transmission of affective aspects of touch. How the perception of affective touch differs across human skin has made substantial progress; however, the majority of previous studies have mainly focused on the relationship between stroking velocities and pleasantness ratings. Here, we investigate how stroking hardness affects the perception of affective touch. Affective tactile stimulation was given with four different hardness of brushes a three different forces, which were presented to either palm or forearm. To quantify the physical factors of the stimuli (brush hardness), ten naive, healthy participants assessed brush hardness using a seven-point scale. Based on these ten participants, five more participants were added to rate the hedonic value of brush stroking using a visual analogue scale (VAS). We found that pleasantness ratings over the skin resulted in a preference for light, soft stroking, which was rated as more pleasant when compared to heavy, hard stroking. Our results show that the hairy skin of the forearm is more susceptible to stroking hardness than the glabrous of the palm in terms of the perception of pleasantness. These findings of the current study extend the growing literature related to the effect of stroking characteristics on pleasantness ratings.
en-copyright=
kn-copyright=

en-aut-name=YuJiabin
en-aut-sei=Yu
en-aut-mei=Jiabin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YangJiajia
en-aut-sei=Yang
en-aut-mei=Jiajia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YuYinghua
en-aut-sei=Yu
en-aut-mei=Yinghua
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=WuQiong
en-aut-sei=Wu
en-aut-mei=Qiong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakahashiSatoshi
en-aut-sei=Takahashi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=EjimaYoshimichi
en-aut-sei=Ejima
en-aut-mei=Yoshimichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=WuJinglong
en-aut-sei=Wu
en-aut-mei=Jinglong
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary, Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary, Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary, Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary, Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary, Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=7
en-affil=Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary, Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=Neuroscience
kn-keyword=Neuroscience
en-keyword=Pleasantness ratings
kn-keyword=Pleasantness ratings
en-keyword=Affective tactile
kn-keyword=Affective tactile
en-keyword=Physical factors
kn-keyword=Physical factors
en-keyword=CT afferents
kn-keyword=CT afferents
en-keyword=Stroking hardness
kn-keyword=Stroking hardness
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=1
article-no=
start-page=220
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191218
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Single-session esophagogastroduodenoscopy and endoscopic ultrasound using a forward-viewing radial scan ultrasonic endoscope
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Endoscopic ultrasound is useful for obtaining high-resolution images of pancreaticobiliary diseases, but is not readily available for physical checkups. In this study, we evaluated the safety and efficacy of single-session esophagogastroduodenoscopy and endoscopic ultrasound in the detection of upper-gastrointestinal and pancreaticobiliary diseases using a forward-viewing radial scan ultrasonic endoscope. <br/>
Methods: A total of 148 patients who were scheduled for upper-gastrointestinal screening using an endoscope were prospectively included. All patients were examined by EUS in combination with EGD using a forward-viewing radial scan ultrasonic endoscope. The primary endpoint was the safety of the procedures. The secondary endpoints were the prevalence of diseases, the basal imaging capability of EUS, the procedure time, total dose of propofol, and the correlation between background factors and the prevalence of pancreatic disease. The imaging capability at each region was scored as 0 (invisible) to 2 (sufficient visualization to evaluate the organs). <br/>
Results: Intraoperative hypotension occurred as an adverse event of intravenous anesthesia in one patient. There were 82 pancreaticobiliary findings and 165 upper-gastrointestinal findings (malignancy not included). Follicular lymphoma of the intra-abdominal lymph nodes was detected in one patient. The mean imaging scores of each section were 1.95 (pancreatic head and papilla), 2.0 (pancreatic body), 1.99 (pancreatic tail), and 1.89 (common bile duct and gallbladder). Age, history of diabetes mellitus, and smoking history were significantly associated with the prevalence of pancreatic diseases. <br/>
Conclusion: The simultaneous performance of EGD and EUS using a new ultrasonic endoscope is tolerable and safe for upper-gastrointestinal and pancreaticobiliary screening.
en-copyright=
kn-copyright=

en-aut-name=UchidaDaisuke
en-aut-sei=Uchida
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KatoHironari
en-aut-sei=Kato
en-aut-mei=Hironari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MatsumotoKazuyuki
en-aut-sei=Matsumoto
en-aut-mei=Kazuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=IshiharaYuki
en-aut-sei=Ishihara
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MatsumiAkihiro
en-aut-sei=Matsumi
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SaragaiYosuke
en-aut-sei=Saragai
en-aut-mei=Yosuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TakadaSaimon
en-aut-sei=Takada
en-aut-mei=Saimon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YabeShuntaro
en-aut-sei=Yabe
en-aut-mei=Shuntaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MuroShinichiro
en-aut-sei=Muro
en-aut-mei=Shinichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TomodaTakeshi
en-aut-sei=Tomoda
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=HoriguchiShigeru
en-aut-sei=Horiguchi
en-aut-mei=Shigeru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology, Okayama University Hospital
kn-affil=
en-keyword=Endoscopic ultrasound
kn-keyword=Endoscopic ultrasound
en-keyword=Diagnostic screening program
kn-keyword=Diagnostic screening program
en-keyword=Pancreatic diseases
kn-keyword=Pancreatic diseases
en-keyword=Biliary tract diseases
kn-keyword=Biliary tract diseases
END

start-ver=1.4
cd-journal=joma
no-vol=21
cd-vols=
no-issue=
article-no=
start-page=42
end-page=56
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191122
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=2-Methylthio Conversion of N6-Isopentenyladenosine in Mitochondrial tRNAs by CDK5RAP1 Promotes the Maintenance of Glioma-Initiating Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=2-Methylthio-N-6-isopentenyl modification of adenosine (ms(2)i(6)A) is an evolutionally conserved modification found in mitochondrial (mt)-tRNAs. Cdk5 regulatory subunit-associated protein 1 (CDK5RAP1) specifically converts N6-isopentenyladenosine (i(6)A) to ms(2)i(6)A at position A37 of four mt-DNA-encoded tRNAs, and the modification regulates efficient mitochondrial translation and energy metabolism in mammals. Here, we report that the ms 2 conversion mediated by CDK5RAP1 in mt-tRNAs is required to sustain glioma-initiating cell (GIC)-related traits. CDK5RAP1 maintained the self-renewal capacity, undifferentiated state, and tumorigenic potential of GICs. This regulation was not related to the translational control of mt-proteins. CDK5RAP1 abrogated the antitumor effect of i(6)A by converting i(6)A to ms (2)i(6) A and protected GICs from excessive autophagy triggered by i(6)A. The elevated activity of CDK5RAP1 contributed to the amelioration of the tumor-suppressive effect of i(6)A and promoted GIC maintenance. This work demonstrates that CDK5RAP1 is crucial for the detoxification of endogenous i(6)A and that GICs readily utilize this mechanism for survival.
en-copyright=
kn-copyright=

en-aut-name=YamamotoTakahiro
en-aut-sei=Yamamoto
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=FujimuraAtsushi
en-aut-sei=Fujimura
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WeiFan-Yan
en-aut-sei=Wei
en-aut-mei=Fan-Yan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShinojimaNaoki
en-aut-sei=Shinojima
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KurodaJun-Ichiro
en-aut-sei=Kuroda
en-aut-mei=Jun-Ichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MukasaAkitake
en-aut-sei=Mukasa
en-aut-mei=Akitake
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TomizawaKazuhito
en-aut-sei=Tomizawa
en-aut-mei=Kazuhito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=2
en-affil=Neutron Therapy Research Center, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Molecular Physiology, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=4
en-affil=Department of Neurosurgery, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=5
en-affil=Department of Neurosurgery, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=6
en-affil=Department of Neurosurgery, Faculty of Life Sciences, Kumamoto University
kn-affil=

affil-num=7
en-affil=Neutron Therapy Research Center, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=19
cd-vols=
no-issue=1
article-no=
start-page=211
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191209
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Prognostic significance of the controlling nutritional status (CONUT) score in patients undergoing hepatectomy for hepatocellular carcinoma: a systematic review and meta-analysis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: The clinical value of the controlling nutritional status (CONUT) score in hepatocellular carcinoma (HCC) has increased. The aim of this meta-analysis was to systematically review the association between the CONUT score and outcomes in patients undergoing hepatectomy for HCC. <br/>
Methods: Embase, Medline Ovid, Web of Science, Cochrane CENTRAL, and Google Scholar were systematically searched. Random effects meta-analyses were conducted to examine the prognostic value of the CONUT score in HCC patients. <br/>
Results: A total of five studies including 4679 patients were found to be eligible and analyzed in the meta-analysis. The CONUT score was significantly associated with overall survival (HR 1.78, 95%CI = 1.20-2.64, P = 0.004, I-2 = 79%), recurrence-free survival (HR 1.34, 95%CI = 1.17-1.53, P < 0.001, I-2 = 16%) and postoperative major complications (OR 1.85, 95%CI: 1.19-2.87, P = 0.006, I-2 = 72%) in HCC patients. Moreover, the CONUT score was associated with the Child-Pugh classification, liver cirrhosis, ICGR15, and tumor differentiation. However, it was not associated with tumor size, tumor number, and microvascular invasion. <br/>
Conclusions: The CONUT score is an independent prognostic indicator of the prognosis and is associated with postoperative major complications and hepatic functional reserve in HCC patients.
en-copyright=
kn-copyright=

en-aut-name=TakagiKosei
en-aut-sei=Takagi
en-aut-mei=Kosei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DomagalaPiotr
en-aut-sei=Domagala
en-aut-mei=Piotr
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=PolakWojciech G.
en-aut-sei=Polak
en-aut-mei=Wojciech G.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=BuettnerStefan
en-aut-sei=Buettner
en-aut-mei=Stefan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IjzermansJan N. M.
en-aut-sei=Ijzermans
en-aut-mei=Jan N. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Surgery, Erasmus MC, University Medical Center Rotterdam
kn-affil=

affil-num=3
en-affil=Department of Surgery, Erasmus MC, University Medical Center Rotterdam
kn-affil=

affil-num=4
en-affil=Department of Surgery, Erasmus MC, University Medical Center Rotterdam
kn-affil=

affil-num=5
en-affil=Department of Surgery, Erasmus MC, University Medical Center Rotterdam
kn-affil=
en-keyword=Controlling nutritional status (CONUT) score
kn-keyword=Controlling nutritional status (CONUT) score
en-keyword=Hepatocellular carcinoma
kn-keyword=Hepatocellular carcinoma
en-keyword=Outcome
kn-keyword=Outcome
en-keyword=Meta-analysis
kn-keyword=Meta-analysis
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=10
article-no=
start-page=223
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191013
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Differential Response of Sugar Beet to Long-Term Mild to Severe Salinity in a Soil-Pot Culture
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Attempts to cultivate sugar beet (Beta vulgaris spp. vulgaris) in the sub-tropical saline soils are ongoing because of its excellent tolerance to salinity. However, the intrinsic adaptive physiology has not been discovered yet in the sub-tropical climatic conditions. In this study, we investigated morpho-physiological attributes, biochemical responses, and yield of sugar beet under a gradient of salinity in the soil-pot culture system to evaluate its adaptive mechanisms. Results exhibited that low and high salinity displayed a differential impact on growth, photosynthesis, and yield. Low to moderate salt stress (75 and 100 mM NaCl) showed no inhibition on growth and photosynthetic attributes. Accordingly, low salinity displayed simulative effect on chlorophyll and antioxidant enzymes activity which contributed to maintaining a balanced H2O2 accumulation and lipid peroxidation. Furthermore, relative water and proline content showed no alteration in low salinity. These factors contributed to improving the yield (tuber weight). On the contrary, 250 mM salinity showed a mostly inhibitory role on growth, photosynthesis, and yield. Collectively, our findings provide insights into the mild-moderate salt adaptation strategy in the soil culture test attributed to increased water content, elevation of photosynthetic pigment, better photosynthesis, and better management of oxidative stress. Therefore, cultivation of sugar beet in moderately saline-affected soils will ensure efficient utilization of lands.
en-copyright=
kn-copyright=

en-aut-name=Tahjib-UI-ArifMd.
en-aut-sei=Tahjib-UI-Arif
en-aut-mei=Md.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SohagAbdullah Al Mamun
en-aut-sei=Sohag
en-aut-mei=Abdullah Al Mamun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AfrinSonya
en-aut-sei=Afrin
en-aut-mei=Sonya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=BasharKazi Khayrul
en-aut-sei=Bashar
en-aut-mei=Kazi Khayrul
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=AfrinTania
en-aut-sei=Afrin
en-aut-mei=Tania
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MahamudA. G. M. Sofi Uddin
en-aut-sei=Mahamud
en-aut-mei=A. G. M. Sofi Uddin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=PolashMohammed Arif Sadik
en-aut-sei=Polash
en-aut-mei=Mohammed Arif Sadik
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HossainMd. Tahmeed
en-aut-sei=Hossain
en-aut-mei=Md. Tahmeed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SohelMd. Abu Taher
en-aut-sei=Sohel
en-aut-mei=Md. Abu Taher
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=BresticMarian
en-aut-sei=Brestic
en-aut-mei=Marian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MurataYoshiyuki
en-aut-sei=Murata
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=3
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Bangladesh Jute Research Institute
kn-affil=

affil-num=5
en-affil=Graduate Training Institute, Bangladesh Agricultural University
kn-affil=

affil-num=6
en-affil=Food Biochemistry Laboratory, Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=7
en-affil=Department of Crop Botany, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=8
en-affil=Department of Biochemistry and Molecular Biology, Faculty of Agriculture, Bangladesh Agricultural University
kn-affil=

affil-num=9
en-affil=Agronomy and Farming System Division, Bangladesh Sugar Crop Research Institute
kn-affil=

affil-num=10
en-affil=Department of Plant Physiology, Faculty of Agrobiology and Food Resources, Slovak University of Agriculture
kn-affil=

affil-num=11
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=antioxidant enzymes
kn-keyword=antioxidant enzymes
en-keyword=photosynthesis
kn-keyword=photosynthesis
en-keyword=reactive oxygen species
kn-keyword=reactive oxygen species
en-keyword=salinity
kn-keyword=salinity
en-keyword=sugar beet
kn-keyword=sugar beet
en-keyword=yield
kn-keyword=yield
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=22
article-no=
start-page=3681
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191108
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Advantage of Alveolar Ridge Augmentation with Bioactive/Bioresorbable Screws Made of Composites of Unsintered Hydroxyapatite and Poly-L-lactide
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We studied human bone healing characteristics and the histological osteogenic environment by using devices made of a composite of uncalcined and unsintered hydroxyapatite (u-HA) and poly-L-lactide (PLLA). In eight cases of fixation, we used u-HA/PLLA screws for maxillary alveolar ridge augmentation, for which mandibular cortical bone block was used in preimplantation surgery. Five appropriate samples with screws were evaluated histologically and immunohistochemically for runt-related transcription factor 2 (RUNX2), transcription factor Sp7 (Osterix), and leptin receptor (LepR). In all cases, histological evaluation revealed that bone components had completely surrounded the u-HA/PLLA screws, and the bone was connected directly to the biomaterial. Inflammatory cells did not invade the space between the bone and the u-HA/PLLA screw. Immunohistochemical evaluation revealed that many cells were positive for RUNX2 or Osterix, which are markers for osteoblast and osteoprogenitor cells, in the tissues surrounding u-HA/PLLA. In addition, many bone marrow-derived mesenchymal stem cells were notably positive for both LepR and RUNX2. The u-HA/PLLA material showed excellent bioactive osteoconductivity and a highly biocompatibility with bone directly attached. In addition, our findings suggest that many bone marrow-derived mesenchymal stem cells and mature osteoblast are present in the osteogenic environment created with u-HA/PLLA screws and that this environment is suitable for osteogenesis.
en-copyright=
kn-copyright=

en-aut-name=SukegawaShintaro 
en-aut-sei=Sukegawa
en-aut-mei=Shintaro 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakanoKeisuke
en-aut-sei=Nakano
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakabatakeKiyofumi
en-aut-sei=Takabatake
en-aut-mei=Kiyofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KannoTakahiro
en-aut-sei=Kanno
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FurukiYoshihiko
en-aut-sei=Furuki
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine
kn-affil=

affil-num=6
en-affil=Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital
kn-affil=
en-keyword=poly-L-lactide
kn-keyword=poly-L-lactide
en-keyword=uncalcined and unsintered hydroxyapatite
kn-keyword=uncalcined and unsintered hydroxyapatite
en-keyword=biocompatibility
kn-keyword=biocompatibility
en-keyword=osteoconductivity
kn-keyword=osteoconductivity
en-keyword=mesenchymal stem cell
kn-keyword=mesenchymal stem cell
END

start-ver=1.4
cd-journal=joma
no-vol=12
cd-vols=
no-issue=9
article-no=
start-page=1557
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190513
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Biomechanical Loading Comparison between Titanium and Unsintered Hydroxyapatite/Poly-L-Lactide Plate System for Fixation of Mandibular Subcondylar Fractures
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Osteosynthesis absorbable materials made of uncalcined and unsintered hydroxyapatite (u-HA) particles, poly-l-lactide (PLLA), and u-HA/PLLA are bioresorbable, and these plate systems have feasible bioactive osteoconductive capacities. However, their strength and stability for fixation in mandibular subcondylar fractures remain unclear. This in vitro study aimed to assess the biomechanical strength of u-HA/PLLA bioresorbable plate systems after internal fixation of mandibular subcondylar fractures. Tensile and shear strength were measured for each u-HA/PLLA and titanium plate system. To evaluate biomechanical behavior, 20 hemimandible replicas were divided into 10 groups, each comprising a titanium plate and a bioresorbable plate. A linear load was applied anteroposteriorly and lateromedially to each group to simulate the muscular forces in mandibular condylar fractures. All samples were analyzed for each displacement load and the displacement obtained by the maximum load. Tensile and shear strength of the u-HA/PLLA plate were each approximately 45% of those of the titanium plates. Mechanical resistance was worst in the u-HA/PLLA plate initially loaded anteroposteriorly. Titanium plates showed the best mechanical resistance during lateromedial loading. Notably, both plates showed similar resistance when a lateromedially load was applied. In the biomechanical evaluation of mandibular condylar fracture treatment, the u-HA/PLLA plates had sufficiently high resistance in the two-plate fixation method.
en-copyright=
kn-copyright=

en-aut-name=SukegawaShintaro
en-aut-sei=Sukegawa
en-aut-mei=Shintaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KannoTakahiro
en-aut-sei=Kanno
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamamotoNorio
en-aut-sei=Yamamoto
en-aut-mei=Norio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=NakanoKeisuke
en-aut-sei=Nakano
en-aut-mei=Keisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TakabatakeKiyofumi
en-aut-sei=Takabatake
en-aut-mei=Kiyofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KawaiHotaka
en-aut-sei=Kawai
en-aut-mei=Hotaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NagatsukaHitoshi
en-aut-sei=Nagatsuka
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=FurukiYoshihiko
en-aut-sei=Furuki
en-aut-mei=Yoshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Kagawa Prefectural Central Hospital
kn-affil=

affil-num=4
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital
kn-affil=
en-keyword=mandibular condylar fracture
kn-keyword=mandibular condylar fracture
en-keyword=unsintered hydroxyapatite
kn-keyword=unsintered hydroxyapatite
en-keyword=poly-l-lactide composite plate
kn-keyword=poly-l-lactide composite plate
en-keyword=bioactive resorbable plate
kn-keyword=bioactive resorbable plate
en-keyword=biomechanical loading evaluation
kn-keyword=biomechanical loading evaluation
en-keyword=fracture fixation
kn-keyword=fracture fixation
END

start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=岡山大学環境管理センター報　第41号
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=岡山大学環境管理センター
kn-aut-sei=岡山大学環境管理センター
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=8
article-no=
start-page=2549
end-page=2557
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190604
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Acquired resistance mechanisms to afatinib in HER2-amplified gastric cancer cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cancer treatment, especially that for breast and lung cancer, has entered a new era and continues to evolve, with the development of genome analysis technology and the advent of molecular targeted drugs including tyrosine kinase inhibitors. Nevertheless, acquired drug resistance to molecular targeted drugs is unavoidable, creating a clinically challenging problem. We recently reported the antitumor effect of a pan-HER inhibitor, afatinib, against human epidermal growth factor receptor 2 (HER2)-amplified gastric cancer cells. The purpose of the present study was to identify the mechanisms of acquired afatinib resistance and to investigate the treatment strategies for HER2-amplified gastric cancer cells. Two afatinib-resistant gastric cancer cell lines were established from 2 HER2-amplified cell lines, N87 and SNU216. Subsequently, we investigated the molecular profiles of resistant cells. The activation of the HER2 pathway was downregulated in N87-derived resistant cells, whereas it was upregulated in SNU216-derived resistant cells. In the N87-derived cell line, both MET and AXL were activated, and combination treatment with afatinib and cabozantinib, a multikinase inhibitor that inhibits MET and AXL, suppressed the cell growth of cells with acquired resistance both in vitro and in vivo. In the SNU216-derived cell line, YES1, which is a member of the Src family, was remarkably activated, and dasatinib, a Src inhibitor, exerted a strong antitumor effect in these cells. In conclusion, we identified MET and AXL activation in addition to YES1 activation as novel mechanisms of afatinib resistance in HER2-driven gastric cancer. Our results also indicated that treatment strategies targeting individual mechanisms of resistance are key to overcoming such resistance.
en-copyright=
kn-copyright=

en-aut-name=YoshiokaTakahiro
en-aut-sei=Yoshioka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=ShienKazuhiko
en-aut-sei=Shien
en-aut-mei=Kazuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakedaTatsuaki
en-aut-sei=Takeda
en-aut-mei=Tatsuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakahashiYuta
en-aut-sei=Takahashi
en-aut-mei=Yuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KuriharaEisuke
en-aut-sei=Kurihara
en-aut-mei=Eisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OgoshiYusuke
en-aut-sei=Ogoshi
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NambaKei
en-aut-sei=Namba
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TorigoeHidejiro
en-aut-sei=Torigoe
en-aut-mei=Hidejiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SatoHiroki
en-aut-sei=Sato
en-aut-mei=Hiroki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TomidaShuta
en-aut-sei=Tomida
en-aut-mei=Shuta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=YamamotoHiromasa
en-aut-sei=Yamamoto
en-aut-mei=Hiromasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=SohJunichi
en-aut-sei=Soh
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

affil-num=1
en-affil=Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Clinical Pharmacy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Bioinformatics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=12
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=13
en-affil=Departments of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=14
en-affil=General Thoracic Surgery, Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=afatinib
kn-keyword=afatinib
en-keyword=gastric cancer
kn-keyword=gastric cancer
en-keyword=HER2
kn-keyword=HER2
en-keyword=MET
kn-keyword=MET
en-keyword=YES1
kn-keyword=YES1
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=4
article-no=
start-page=509
end-page=518
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191204
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effects of loading contact on electric-power generation of lead zirconate titanate piezoelectric ceramic plate
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To better understand the generation of electric power for piezoelectric PbZrTiO3 (PZT) ceramic plate (phi 25 mm), an attempt was made to investigate experimentally and numerically electric-power generation characteristics during cyclic bending under various loading fixtures (phi 0-phi 20 mm), i.e., different contact areas. Increasing the load-contact area on the PZT ceramic leads to a nonlinear decrease in the generated voltage. Decreasing contact area basically enhances the generated voltage, although the voltage saturates during loading when the contact area is less than phi 5 mm. A similar voltage is generated for phi 0 and phi 5 mm, which is attributed to strain status (ratio of compressive and tensile strain) and material failure due to different stress distribution in the PZT ceramic. On the basis of the obtained electric generation voltage, suitable loading conditions are clarified by loading with the phi 5 mm fixture, which generates a higher voltage and a longer lifetime of the PZT ceramic. From this approach, it is appeared that the area contact with the area ratio of 0.04 (phi 5 mm/phi 20 mm) is suitable to obtain the high efficiency of the electric voltage.
en-copyright=
kn-copyright=

en-aut-name=OkayasuMitsuhiro
en-aut-sei=Okayasu
en-aut-mei=Mitsuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OgawaTsukasa
en-aut-sei=Ogawa
en-aut-mei=Tsukasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=piezoelectric ceramic
kn-keyword=piezoelectric ceramic
en-keyword=lead zirconate titanate ceramic
kn-keyword=lead zirconate titanate ceramic
en-keyword=electric power generation
kn-keyword=electric power generation
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=
article-no=
start-page=100938
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Long-term spontaneous remission with active surveillance in IgG4-related pleuritis: A case report and literature review
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Pleural effusion is a relatively rare feature of IgG4-related disease (IgG4-RD). Here, we report a case of a 72-year-old woman who presented with pleural effusion. Although the pleural adenosine deaminase level was increased, surgical biopsy of the pleura and left inguinal lymph node indicated that the effusion was due to IgG4-RD. Active surveillance was initiated because serum IgG4 and pleural effusion naturally decreased and then completely disappeared. The patient has shown no recurrence for >4 years. This case suggests that pleural biopsy can be used to distinguish IgG4-RD from tuberculosis; moreover, some cases with pleural effusion could improve without treatment.
en-copyright=
kn-copyright=

en-aut-name=MakimotoGo
en-aut-sei=Makimoto
en-aut-mei=Go
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhashiKadoaki
en-aut-sei=Ohashi
en-aut-mei=Kadoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TaniguchiKohei
en-aut-sei=Taniguchi
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SohJunichi
en-aut-sei=Soh
en-aut-mei=Junichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TaniguchiAkihiko
en-aut-sei=Taniguchi
en-aut-mei=Akihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MiyaharaNobuaki
en-aut-sei=Miyahara
en-aut-mei=Nobuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ToyookaShinichi
en-aut-sei=Toyooka
en-aut-mei=Shinichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YoshinoTadashi
en-aut-sei=Yoshino
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=6
en-affil=Department of Medical Technology, Okayama University Graduate School of Health Sciences
kn-affil=

affil-num=7
en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Allergy and Respiratory Medicine, Okayama University Hospital
kn-affil=
en-keyword=IgG4-related disease
kn-keyword=IgG4-related disease
en-keyword=Pleural effusion
kn-keyword=Pleural effusion
en-keyword=Adenosine deaminase
kn-keyword=Adenosine deaminase
en-keyword=Pleural biopsy
kn-keyword=Pleural biopsy
en-keyword=Spontaneous remission
kn-keyword=Spontaneous remission
END

start-ver=1.4
cd-journal=joma
no-vol=28
cd-vols=
no-issue=
article-no=
start-page=100947
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=2019
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A case of axillary lymphadenitis caused by Mycobacterium intracellulare in an immunocompetent patient
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Axillary lymphadenitis caused by non-tuberculous mycobacteria is rare and has been reported in immunocompromised hosts. Herein, we report the case of a 67-year-old man without immunodeficiency who developed right axillary lymphadenitis caused by Mycobacterium intracellulare and showed a small nodular shadow in the left pulmonary apex. Biopsy of the right axillary lymph node revealed several epithelioid granulomas, and the culture of the lymph node aspirate yielded Mycobacterium intracellulare. The lymph node lesion and left lung apex shadow resolved spontaneously after careful outpatient monitoring. This case suggests that axillary lymphadenitis could be caused by Mycobacterium intracellulare in an immunocompetent patient.
en-copyright=
kn-copyright=

en-aut-name=ItanoJunko
en-aut-sei=Itano
en-aut-mei=Junko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhashiKadoaki
en-aut-sei=Ohashi
en-aut-mei=Kadoaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SenooSatoru
en-aut-sei=Senoo
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OdaNaohiro
en-aut-sei=Oda
en-aut-mei=Naohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishiiKazuya
en-aut-sei=Nishii
en-aut-mei=Kazuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TaniguchiAkihiko
en-aut-sei=Taniguchi
en-aut-mei=Akihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MiyaharaNobuaki
en-aut-sei=Miyahara
en-aut-mei=Nobuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MaedaYoshinobu
en-aut-sei=Maeda
en-aut-mei=Yoshinobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KiuraKatsuyuki
en-aut-sei=Kiura
en-aut-mei=Katsuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=

affil-num=3
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Medical Technology, Okayama University Graduate School of Health Sciences
kn-affil=

affil-num=8
en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Respiratory Medicine, Okayama University Hospital
kn-affil=
en-keyword=Axillary lymphadenitis
kn-keyword=Axillary lymphadenitis
en-keyword=Mycobacterium avium complex infection
kn-keyword=Mycobacterium avium complex infection
en-keyword=Mycobacterium intracellulare
kn-keyword=Mycobacterium intracellulare
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=38
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190729
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Long-stay pediatric patients in Japanese intensive care units: their significant presence and a newly developed, simple predictive score
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=BACKGROUND:<br/>
The length of stay (LOS) in intensive care units (ICUs) has been used as a good indicator not only for resource consumption but also for health outcomes of patients. However, data regarding pediatric LOS in Japanese ICUs are limited. The primary aim of this study was to characterize the Japanese pediatric ICU patients based on their LOS. Second, we aimed to develop a simple scoring system to predict long-stay pediatric ICU patients on admission.<br/>
METHODS:<br/>
We performed a retrospective cohort study using consecutive pediatric data (aged <?16?years) registered in the Japanese Registry of Pediatric Acute Care (JaRPAC) from October 2013 to September 2016, which consisted of descriptive and diagnostic information. The factors for long-stay patients (LSPs; LOS?>?14?days) were identified using multiple regression analysis, and subsequently, a simple predictive scoring system was developed based on the results. The validity of the score was prospectively tested using data from the JaRPAC registration from October 2016 to September 2017.<br/>
RESULTS:<br/>
Overall, 4107 patients were included. Although LSPs were few (8.0% [n =?330]), they consumed 38.0% of ICU bed days (9750 for LSPs versus 25,659 overall). Mortality was seven times higher in LSPs than in short-stay patients (9.1% versus 1.3%). An 11-variable simple predictive scoring system was constructed, including Pediatric Index of Mortality 2???1 (2 points), liver dysfunction (non-post operation) (2 points), post-cardiopulmonary resuscitation (1 point), circulatory disorder (1 point), post-operative management of liver transplantation (1 point), encephalitis/encephalopathy (1 point), myocarditis/cardiomyopathy (1 point), congenital heart disease (non-post operation) (1 point), lung tissue disease (1 point), Pediatric Cerebral Performance Category scores ??2 (1 point), and age <?2?years (1 point). A score of ??3 points yielded an area under the receiver operating characteristic curve (AUC) of 0.79, sensitivity of 87.0%, and specificity of 59.4% in the original dataset. Reproducibility was confirmed with the internal validation dataset (AUC 0.80, sensitivity 92.6%, and specificity 60.2%).<br/>
CONCLUSIONS:<br/>
Pediatric LSPs possess a significant presence in Japanese ICUs with high rates of bed utilization and mortality. The newly developed predictive scoring system may identify pediatric LSPs on admission.
en-copyright=
kn-copyright=

en-aut-name=KnaupEmily
en-aut-sei=Knaup
en-aut-mei=Emily
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NosakaNobuyuki
en-aut-sei=Nosaka
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YorifujiTakashi
en-aut-sei=Yorifuji
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsukaharaKohei
en-aut-sei=Tsukahara
en-aut-mei=Kohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NaitouHiromichi
en-aut-sei=Naitou
en-aut-mei=Hiromichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TsukaharaHirokazu
en-aut-sei=Tsukahara
en-aut-mei=Hirokazu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakaoAtsunori
en-aut-sei=Nakao
en-aut-mei=Atsunori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=the JaRPAC Study Group
en-aut-sei=the JaRPAC Study Group
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Human Ecology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Pediatrics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Emergency, Critical Care and Disaster Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=
kn-affil=
en-keyword=Decision support
kn-keyword=Decision support
en-keyword=Intensive care
kn-keyword=Intensive care
en-keyword=Length of stay
kn-keyword=Length of stay
en-keyword=Mortality
kn-keyword=Mortality
en-keyword=Outcome
kn-keyword=Outcome
en-keyword=Pediatric
kn-keyword=Pediatric
en-keyword=Risk
kn-keyword=Risk
en-keyword=Prediction rules
kn-keyword=Prediction rules
en-keyword=Scoring system
kn-keyword=Scoring system
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=12
article-no=
start-page=1007
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191121
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=The Relationship between Uterine, Fecal, Bedding, and Airborne Dust Microbiota from Dairy Cows and Their Environment: A Pilot Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Simple Summary After calving, dairy cows face the risk of negative energy balance, inflammation, and immunosuppression, which may result in bacterial infection and disruption of the normal microbiota, thus encouraging the development of metritis and endometritis. This study characterized uterine, fecal, bedding, and airborne dust microbiota from postpartum dairy cows and their environment during summer and winter. The results clarify the importance of microbiota in cowshed environments, i.e., bedding and airborne dust, in understanding the postpartum uterine microbiota of dairy cows. <br/><br/>
Abstract The aim of this study was to characterize uterine, fecal, bedding, and airborne dust microbiota from postpartum dairy cows and their environment. The cows were managed by the free-stall housing system, and samples for microbiota and serum metabolite assessment were collected during summer and winter when the cows were at one and two months postpartum. Uterine microbiota varied between seasons; the five most prevalent taxa were Enterobacteriaceae, Moraxellaceae, Ruminococcaceae, Staphylococcaceae, and Lactobacillaceae during summer, and Ruminococcaceae, Lachnospiraceae, Bacteroidaceae, Moraxellaceae, and Clostridiaceae during winter. Although Actinomycetaceae and Mycoplasmataceae were detected at high abundance in several uterine samples, the relationship between the uterine microbiota and serum metabolite concentrations was unclear. The fecal microbiota was stable regardless of the season, whereas bedding and airborne dust microbiota varied between summer and winter. With regards to uterine, bedding, and airborne dust microbiota, Enterobacteriaceae, Moraxellaceae, Staphylococcaceae, and Lactobacillaceae were more abundant during summer, and Ruminococcaceae, Lachnospiraceae, Bacteroidaceae, and Clostridiaceae were more abundant during winter. Canonical analysis of principal coordinates confirmed the relationship between uterine and cowshed microbiota. These results indicated that the uterine microbiota may vary when the microbiota in cowshed environments changes.
en-copyright=
kn-copyright=

en-aut-name=NguyenThuong T.
en-aut-sei=Nguyen
en-aut-mei=Thuong T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MiyakeAyumi
en-aut-sei=Miyake
en-aut-mei=Ayumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TranTu T. M.
en-aut-sei=Tran
en-aut-mei=Tu T. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TsurutaTakeshi
en-aut-sei=Tsuruta
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NishinoNaoki
en-aut-sei=Nishino
en-aut-mei=Naoki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Okayama Prefecture Livestock Research Institute
kn-affil=

affil-num=3
en-affil=Faculty of Agriculture and Food Technology, Tien Giang University
kn-affil=

affil-num=4
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Animal Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=cowshed
kn-keyword=cowshed
en-keyword=environment
kn-keyword=environment
en-keyword=microbiota
kn-keyword=microbiota
en-keyword=uterus
kn-keyword=uterus
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=23
article-no=
start-page=5992
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191128
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Comprehensive Identification of PTI Suppressors in Type III Effector Repertoire Reveals that Ralstonia solanacearum Activates Jasmonate Signaling at Two Different Steps
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Ralstonia solanacearum is the causative agent of bacterial wilt in many plants. To identify R. solanacearum effectors that suppress pattern-triggered immunity (PTI) in plants, we transiently expressed R. solanacearum RS1000 effectors in Nicotiana benthamiana leaves and evaluated their ability to suppress the production of reactive oxygen species (ROS) triggered by flg22. Out of the 61 effectors tested, 11 strongly and five moderately suppressed the flg22-triggered ROS burst. Among them, RipE1 shared homology with the Pseudomonas syringae cysteine protease effector HopX1. By yeast two-hybrid screening, we identified jasmonate-ZIM-domain (JAZ) proteins, which are transcriptional repressors of the jasmonic acid (JA) signaling pathway in plants, as RipE1 interactors. RipE1 promoted the degradation of JAZ repressors and induced the expressions of JA-responsive genes in a cysteine-protease-activity-dependent manner. Simultaneously, RipE1, similarly to the previously identified JA-producing effector RipAL, decreased the expression level of the salicylic acid synthesis gene that is required for the defense responses against R. solanacearum. The undecuple mutant that lacks 11 effectors with a strong PTI suppression activity showed reduced growth of R. solanacearum in Nicotiana plants. These results indicate that R. solanacearum subverts plant PTI responses using multiple effectors and manipulates JA signaling at two different steps to promote infection.
en-copyright=
kn-copyright=

en-aut-name=NakanoMasahito
en-aut-sei=Nakano
en-aut-mei=Masahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MukaiharaTakafumi
en-aut-sei=Mukaihara
en-aut-mei=Takafumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Research Institute for Biological Sciences, Okayama (RIBS)
kn-affil=
en-keyword=Ralstonia solanacearum
kn-keyword=Ralstonia solanacearum
en-keyword=type III effector
kn-keyword=type III effector
en-keyword=jasmonic acid
kn-keyword=jasmonic acid
en-keyword=salicylic acid
kn-keyword=salicylic acid
en-keyword=Nicotiana plants
kn-keyword=Nicotiana plants
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=23
article-no=
start-page=5885
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191123
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Current Treatment Strategies and Nanoparticle-Mediated Drug Delivery Systems for Pulmonary Arterial Hypertension
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=There are three critical pathways for the pathogenesis and progression of pulmonary arterial hypertension (PAH): the prostacyclin (prostaglandin I-2) (PGI(2)), nitric oxide (NO), and endothelin pathways. The current approved drugs targeting these three pathways, including prostacyclin (PGI(2)), phosphodiesterase type-5 (PDE5) inhibitors, and endothelin receptor antagonists (ERAs), have been shown to be effective, however, PAH remains a severe clinical condition and the long-term survival of patients with PAH is still suboptimal. The full therapeutic abilities of available drugs are reduced by medication, patient non-compliance, and side effects. Nanoparticles are expected to address these problems by providing a novel drug delivery approach for the treatment of PAH. Drug-loaded nanoparticles for local delivery can optimize the efficacy and minimize the adverse effects of drugs. Prostacyclin (PGI(2)) analogue, PDE5 inhibitors, ERA, pitavastatin, imatinib, rapamycin, fasudil, and oligonucleotides-loaded nanoparticles have been reported to be effective in animal PAH models and in vitro studies. However, the efficacy and safety of nanoparticle mediated-drug delivery systems for PAH treatment in humans are unknown and further clinical studies are required to clarify these points.
en-copyright=
kn-copyright=

en-aut-name=NakamuraKazufumi
en-aut-sei=Nakamura
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=AkagiSatoshi
en-aut-sei=Akagi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=EjiriKentaro
en-aut-sei=Ejiri
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YoshidaMasashi
en-aut-sei=Yoshida
en-aut-mei=Masashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MiyoshiToru
en-aut-sei=Miyoshi
en-aut-mei=Toru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TohNorihisa
en-aut-sei=Toh
en-aut-mei=Norihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakagawaKoji
en-aut-sei=Nakagawa
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=TakayaYoichi
en-aut-sei=Takaya
en-aut-mei=Yoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=MatsubaraHiromi
en-aut-sei=Matsubara
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Division of Cardiology, National Hospital Organization Okayama Medical Center
kn-affil=

affil-num=10
en-affil= Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=pulmonary arterial hypertension
kn-keyword=pulmonary arterial hypertension
en-keyword=prostaglandin I-2
kn-keyword=prostaglandin I-2
en-keyword=nitric oxide
kn-keyword=nitric oxide
en-keyword=endothelin
kn-keyword=endothelin
END

start-ver=1.4
cd-journal=joma
no-vol=26
cd-vols=
no-issue=5
article-no=
start-page=399
end-page=409
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190803
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of molecular markers associated with resistance to Meloidogyne incognita by performing quantitative trait locus analysis and genome-wide association study in sweetpotato
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The southern root-knot nematode, Meloidogyne incognita, is a pest that decreases yield and the quality of sweetpotato [Ipomoea batatas (L.) Lam.]. There is a demand to produce resistant cultivars and develop DNA markers to select this trait. However, sweetpotato is hexaploid, highly heterozygous, and has an enormous genome (similar to 3 Gb), which makes genetic linkage analysis difficult. In this study, a high-density linkage map was constructed based on retrotransposon insertion polymorphism, simple sequence repeat, and single nucleotide polymorphism markers. The markers were developed using F-1 progeny between J-Red, which exhibits resistance to multiple races of M. incognita, and Choshu, which is susceptible to multiple races of such pest. Quantitative trait locus (QTL) analysis and a genome-wide association study detected highly effective QTLs for resistance against three races, namely, SP1, SP4, and SP6-1, in the Ib01-6 J-Red linkage group. A polymerase chain reaction marker that can identify genotypes based on single nucleotide polymorphisms located in this QTL region can discriminate resistance from susceptibility in the F-1 progeny at a rate of 70%. Thus, this marker could be helpful in selecting sweetpotato cultivars that are resistant to multiple races of M. incognita.
en-copyright=
kn-copyright=

en-aut-name=SasaiRumi
en-aut-sei=Sasai
en-aut-mei=Rumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TabuchiHiroaki
en-aut-sei=Tabuchi
en-aut-mei=Hiroaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShirasawaKenta
en-aut-sei=Shirasawa
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KishimotoKazuki
en-aut-sei=Kishimoto
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SatoShusei
en-aut-sei=Sato
en-aut-mei=Shusei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OkadaYoshihiro
en-aut-sei=Okada
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KuramotoAkihide
en-aut-sei=Kuramoto
en-aut-mei=Akihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KobayashiAkira
en-aut-sei=Kobayashi
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=IsobeSachiko
en-aut-sei=Isobe
en-aut-mei=Sachiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TaharaMakoto
en-aut-sei=Tahara
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=MondenYuki
en-aut-sei=Monden
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Kyusyu Okinawa Agricultural Research Center, National Agriculture and Food Research Organization
kn-affil=

affil-num=3
en-affil=Kazusa DNA Research Institute
kn-affil=

affil-num=4
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Life Science, Tohoku University
kn-affil=

affil-num=6
en-affil=Kyusyu Okinawa Agricultural Research Center, National Agriculture and Food Research Organization
kn-affil=

affil-num=7
en-affil=Graduate School of Agriculture, Kyoto University
kn-affil=

affil-num=8
en-affil=Kyusyu Okinawa Agricultural Research Center, National Agriculture and Food Research Organization
kn-affil=

affil-num=9
en-affil=Kazusa DNA Research Institute
kn-affil=

affil-num=10
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=11
en-affil=Graduate School of Environmental and Life Science, Okayama University
kn-affil=
en-keyword=sweetpotato
kn-keyword=sweetpotato
en-keyword=GWAS
kn-keyword=GWAS
en-keyword=QTL mapping
kn-keyword=QTL mapping
en-keyword=polyploids
kn-keyword=polyploids
en-keyword=marker-assisted breeding
kn-keyword=marker-assisted breeding
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=23
article-no=
start-page=6078
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Spinal cord injury (SCI) results in neural tissue loss and so far untreatable functional impairment. In addition, at the initial injury site, inflammation induces secondary damage, and glial scar formation occurs to limit inflammation-mediated tissue damage. Consequently, it obstructs neural regeneration. Many studies have been conducted in the field of SCI; however, no satisfactory treatment has been established to date. Hepatocyte growth factor (HGF) is one of the neurotrophic growth factors and has been listed as a candidate medicine for SCI treatment. The highlighted effects of HGF on neural regeneration are associated with its anti-inflammatory and anti-fibrotic activities. Moreover, HGF exerts positive effects on transplanted stem cell differentiation into neurons. This paper reviews the mechanisms underlying the therapeutic effects of HGF in SCI recovery, and introduces recent advances in the clinical applications of HGF therapy.
en-copyright=
kn-copyright=

en-aut-name=YamaneKentaro
en-aut-sei=Yamane
en-aut-mei=Kentaro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MisawaHaruo
en-aut-sei=Misawa
en-aut-mei=Haruo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakigawaTomoyuki
en-aut-sei=Takigawa
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ItoYoshihiro
en-aut-sei=Ito
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=OzakiToshifumi
en-aut-sei=Ozaki
en-aut-mei=Toshifumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsukawaAkihiro
en-aut-sei=Matsukawa
en-aut-mei=Akihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Intelligent Orthopaedic System Development, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Nano Medical Engineering Laboratory, RIKEN
kn-affil=

affil-num=5
en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=hepatocyte growth factor
kn-keyword=hepatocyte growth factor
en-keyword=spinal cord injury
kn-keyword=spinal cord injury
en-keyword=neural regeneration
kn-keyword=neural regeneration
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=2
article-no=
start-page=023D01
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190222
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Gamma-ray spectrum from thermal neutron capture on gadolinium-157
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We have measured the -ray energy spectrum from the thermal neutron capture, Gd, on an enriched Gd target (GdO) in the energy range from 0.11 MeV up to about 8 MeV. The target was placed inside the germanium spectrometer of the ANNRI detector at J-PARC and exposed to a neutron beam from the Japan Spallation Neutron Source (JSNS). Radioactive sources (Co, Cs, and Eu) and the Cl(,) reaction were used to determine the spectrometers detection efficiency for rays at energies from 0.3 to 8.5 MeV. Using a Geant4-based Monte Carlo simulation of the detector and based on our data, we have developed a model to describe the -ray spectrum from the thermal Gd(,) reaction. While we include the strength information of 15 prominent peaks above 5 MeV and associated peaks below 1.6 MeV from our data directly into the model, we rely on the theoretical inputs of nuclear level density and the photon strength function of Gd to describe the continuum -ray spectrum from the Gd(,) reaction. Our model combines these two components. The results of the comparison between the observed -ray spectra from the reaction and the model are reported in detail.
en-copyright=
kn-copyright=

en-aut-name=HagiwaraKaito
en-aut-sei=Hagiwara
en-aut-mei=Kaito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YanoTakatomi
en-aut-sei=Yano
en-aut-mei=Takatomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TanakaTomoyuki
en-aut-sei=Tanaka
en-aut-mei=Tomoyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ReenMandeep Singh
en-aut-sei=Reen
en-aut-mei=Mandeep Singh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=DasPretam Kumar
en-aut-sei=Das
en-aut-mei=Pretam Kumar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=LorenzSebastian
en-aut-sei=Lorenz
en-aut-mei=Sebastian
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=OuIwa
en-aut-sei=Ou
en-aut-mei=Iwa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SudoTakashi
en-aut-sei=Sudo
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamadaYoshiyuki
en-aut-sei=Yamada
en-aut-mei=Yoshiyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=MoriTakaaki
en-aut-sei=Mori
en-aut-mei=Takaaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KayanoTsubasa
en-aut-sei=Kayano
en-aut-mei=Tsubasa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=DhirRohit
en-aut-sei=Dhir
en-aut-mei=Rohit
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KoshioYusuke
en-aut-sei=Koshio
en-aut-mei=Yusuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=SakudaMakoto
en-aut-sei=Sakuda
en-aut-mei=Makoto
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KimuraAtsushi
en-aut-sei=Kimura
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

en-aut-name=NakamuraShoji
en-aut-sei=Nakamura
en-aut-mei=Shoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=16
ORCID=

en-aut-name=IwamotoNobuyuki
en-aut-sei=Iwamoto
en-aut-mei=Nobuyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=17
ORCID=

en-aut-name=HaradaHideo
en-aut-sei=Harada
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=18
ORCID=

en-aut-name=WurmMichael
en-aut-sei=Wurm
en-aut-mei=Michael
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=19
ORCID=

en-aut-name=FocillonWilliam
en-aut-sei=Focillon
en-aut-mei=William
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=20
ORCID=

en-aut-name=GoninMichel
en-aut-sei=Gonin
en-aut-mei=Michel
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=21
ORCID=

en-aut-name=AliAjmi
en-aut-sei=Ali
en-aut-mei=Ajmi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=22
ORCID=

en-aut-name=CollazuolGianmaria
en-aut-sei=Collazuol
en-aut-mei=Gianmaria
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=23
ORCID=

affil-num=1
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=2
en-affil=Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=3
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=10
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=11
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=12
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=13
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=14
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=15
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=16
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=17
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=18
en-affil=Japan Atomic Energy Agency
kn-affil=

affil-num=19
en-affil=Institut f?r Physik, Johannes Gutenberg-Universit?t Mainz
kn-affil=

affil-num=20
en-affil=D?partement de Physique, ?cole Polytechnique
kn-affil=

affil-num=21
en-affil=D?partement de Physique, ?cole Polytechnique
kn-affil=

affil-num=22
en-affil=Department of Physics, Okayama University
kn-affil=

affil-num=23
en-affil=Universit? di Padova and INFN, Dipartimento di Fisica
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=e8146
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191129
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Combined effects of body mass index and unhealthy behaviors on disability in older Japanese adults: the Okayama study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Body mass index (BMI) is a significant predictor of functional disability in older adults. However, when evaluated, the association between BMI and incident functional disability, considering behaviors only as covariates or not, may not be appropriate. The primary purpose of the study was to investigate the combined effects of BMI and unhealthy behaviors on the risk of incident functional disability. <br/>
Methods: This was a retrospective cohort study that took place in Okayama City, Japan. Data on BMI and unhealthy behaviors were obtained using the health check-up questionnaire. The certification of Long-Term Care Insurance was used to measure functional disability. Cox proportional hazard models were used; adjusted hazard ratios (HRs) with 95% confidence interval (CI) were calculated for incidence of functional disability across categories of BMI and number of unhealthy behaviors. <br/>
Results: The relationship between BMI and incident functional disability was U-shaped (HR = 1.18, 95% CI [1.11-1.25], among the underweight range; and 1.26 [1.19-1.34] among the obesity range), and its risk was significantly higher within the normal-to-overweight range of BMI values with co-occurring unhealthy behaviors (with normal weight range and one, 1.17 [1.01-1.21]; two, 1.29 [1.18-1.41]; and three or four unhealthy behaviors 1.38 [1.24-1.54]; as well as among overweight range and one, 1.16 [1.05-1.27]; two, 1.26 [1.15-1.38]; and three or four unhealthy behaviors, 1.47 [1.31-1.64]). In each BMI category, the risk of incident functional disability increased with increasing number of unhealthy behaviors (p < 0.05 for linear tread), with the highest risk (1.87 [1.58-2.20]) occurring in combination with at least three unhealthy behaviors with BMI >= 27.5, for both sexes (2.20 [1.64-2.92] in men and 1.66 [1.35-2.04] in women). <br/>
Conclusion: It is necessary to consider the combined effects of BMI and behaviors on incident functional disability. Furthermore, interventions targeting multiple behaviors should be considered as such interventions may offer greater benefits than simple interventions.
en-copyright=
kn-copyright=

en-aut-name=LiuYangyang
en-aut-sei=Liu
en-aut-mei=Yangyang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MitsuhashiToshiharu
en-aut-sei=Mitsuhashi
en-aut-mei=Toshiharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamakawaMichiyo
en-aut-sei=Yamakawa
en-aut-mei=Michiyo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SasaiMegumi
en-aut-sei=Sasai
en-aut-mei=Megumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsudaToshihide
en-aut-sei=Tsuda
en-aut-mei=Toshihide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=DoiHiroyuki
en-aut-sei=Doi
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=HamadaJun
en-aut-sei=Hamada
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Epidemiology and Preventive Medicine, Graduate School of Medicine,Gifu University
kn-affil=

affil-num=4
en-affil=Sri Lanka Office, Japan International Cooperation Agency
kn-affil=

affil-num=5
en-affil=Department of Human Ecology, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Health Economics and Policy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=Elderly
kn-keyword=Elderly
en-keyword=Disability
kn-keyword=Disability
en-keyword=Body mass index
kn-keyword=Body mass index
en-keyword=Long-term care insurance
kn-keyword=Long-term care insurance
en-keyword=Unhealthy behaviors
kn-keyword=Unhealthy behaviors
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=12
article-no=
start-page=e033462
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191211
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Fall-related mortality trends in older Japanese adults aged >= 65 years: a nationwide observational study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=OBJECTIVES:<br/>
Fall-related mortality among older adults is a major public health issue, especially for ageing societies. This study aimed to investigate current trends in fall-related mortality in Japan using nationwide population-based data covering 1997-2016.<br/>
DESIGN:<br/>
We analysed fall-related deaths among older persons aged ?65 years using the data provided by the Japanese Ministry of Health, Labour and Welfare.<br/>
RESULTS:<br/>
The crude and age-standardised mortality rates were calculated per 100 000 persons by stratifying by age (65-74, 75-84 and ?85 years) and sex. To identify trend changes, a joinpoint regression model was applied by estimating change points and annual percentage change (APC). The total number of fall-related deaths in Japan increased from 5872 in 1997 to 8030 in 2016, of which 78.8% involved persons aged ?65 years. The younger population (65-74 years) showed continuous and faster-decreasing trends for both men and women. Average APC among men aged ?75 years did not decrease. Among middle-aged and older women (75-84 and ?85 years) decreasing trends were observed. Furthermore, the age-adjusted mortality rate of men was approximately twice that of women, and it showed a faster decrease for women.<br/>
CONCLUSIONS:<br/>
Although Japanese healthcare has shown improvement in preventing fall-related deaths over the last two decades, the crude mortality for those aged over 85 years remains high, indicating difficulty in reducing fall-related deaths in the super-aged population. Further investigations to uncover causal factors for falls in older populations are required.
en-copyright=
kn-copyright=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KoyamaToshihiro
en-aut-sei=Koyama
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ZamamiYoshito
en-aut-sei=Zamami
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TatebeYasuhisa
en-aut-sei=Tatebe
en-aut-mei=Yasuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FunahashiTomoko
en-aut-sei=Funahashi
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ShinomiyaKazuaki
en-aut-sei=Shinomiya
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HinotsuShiro
en-aut-sei=Hinotsu
en-aut-mei=Shiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=RakugiHiromi
en-aut-sei=Rakugi
en-aut-mei=Hiromi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KanoMitsunobu R.
en-aut-sei=Kano
en-aut-mei=Mitsunobu R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

affil-num=1
en-affil=Department of General Internal Medicine, Osaka University Hospital
kn-affil=

affil-num=2
en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School
kn-affil=

affil-num=4
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=5
en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Pharmaceutical Care and Clinical Pharmacy, Faculty of Pharmaceutical Sciences Tokushima Bunri University
kn-affil=

affil-num=7
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Department of Biostatistics, Sapporo Medical University
kn-affil=

affil-num=9
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=10
en-affil=Department of General Internal Medicine, Osaka University Hospital
kn-affil=

affil-num=11
en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
en-keyword=adult intensive & critical care
kn-keyword=adult intensive & critical care
en-keyword=epidemiology
kn-keyword=epidemiology
en-keyword=geriatric medicine
kn-keyword=geriatric medicine
en-keyword=health & safety
kn-keyword=health & safety
en-keyword=health policy
kn-keyword=health policy
en-keyword=public health
kn-keyword=public health
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=
article-no=
start-page=20235
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Place of death trends among patients with dementia in Japan: a population-based observational study 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Dementia is a major public health concern in ageing societies. Although the population of Japan is among the most aged worldwide, long-term trends in the place of death (PoD) among patients with dementia is unknown. In this Japanese nationwide observational study, we analysed trends in PoD using the data of patients with dementia who were aged >= 65 years and died during 1999-2016. Trends in the crude death rates and PoD frequencies were analysed using the Joinpoint regression model. Changes in these trends were assessed using the Joinpoint regression analysis in which significant change points, the annual percentage change (APC) and average APCs (AAPC) in hospitals, homes, or nursing homes were estimated. During 1999-2016, the number of deaths among patients with dementia increased from 3,235 to 23,757 (total: 182,000). A trend analysis revealed increased mortality rates, with an AAPC of 8.2% among men and 9.3% among women. Most patients with dementia died in the hospital, although the prevalence of hospital deaths decreased (AAPC: -1.0%). Moreover, the prevalence of nursing home deaths increased (AAPC: 5.6%), whereas the prevalence of home deaths decreased (AAPC: -5.8%). These findings support a reconsideration of the end-of-life care provided to patients with dementia.
en-copyright=
kn-copyright=

en-aut-name=KoyamaToshihiro
en-aut-sei=Koyama
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SasakiMisato
en-aut-sei=Sasaki
en-aut-mei=Misato
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=HagiyaHideharu
en-aut-sei=Hagiya
en-aut-mei=Hideharu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ZamamiYoshito
en-aut-sei=Zamami
en-aut-mei=Yoshito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FunahashiTomoko
en-aut-sei=Funahashi
en-aut-mei=Tomoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OhshimaAyako
en-aut-sei=Ohshima
en-aut-mei=Ayako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TatebeYasuhisa
en-aut-sei=Tatebe
en-aut-mei=Yasuhisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MikamiNaoko
en-aut-sei=Mikami
en-aut-mei=Naoko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ShinomiyaKazuaki
en-aut-sei=Shinomiya
en-aut-mei=Kazuaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KitamuraYoshihisa
en-aut-sei=Kitamura
en-aut-mei=Yoshihisa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=HinotsuShiro
en-aut-sei=Hinotsu
en-aut-mei=Shiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=KanoMitsunobu R.
en-aut-sei=Kano
en-aut-mei=Mitsunobu R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

affil-num=1
en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Clinical Pharmacology and Therapeutics, Tokushima University Graduate School
kn-affil=

affil-num=5
en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=7
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=8
en-affil=Division of Pharmacy, Chiba University Hospital
kn-affil=

affil-num=9
en-affil=Department of Pharmaceutical Care and Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
kn-affil=

affil-num=10
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=11
en-affil=Department of Pharmacy, Okayama University Hospital
kn-affil=

affil-num=12
en-affil=Department of Biostatistics, Sapporo Medical University
kn-affil=

affil-num=13
en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=21
article-no=
start-page=E5402
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Animal Models for Parkinson's Disease Research: Trends in the 2000s
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Parkinson's disease (PD) is a chronic and progressive movement disorder and the second most common neurodegenerative disease. Although many studies have been conducted, there is an unmet clinical need to develop new treatments because, currently, only symptomatic therapies are available. To achieve this goal, clarification of the pathology is required. Attempts have been made to emulate human PD and various animal models have been developed over the decades. Neurotoxin models have been commonly used for PD research. Recently, advances in transgenic technology have enabled the development of genetic models that help to identify new approaches in PD research. However, PD animal model trends have not been investigated. Revealing the trends for PD research will be valuable for increasing our understanding of the positive and negative aspects of each model. In this article, we clarified the trends for animal models that were used to research PD in the 2000s, and we discussed each model based on these trends.
en-copyright=
kn-copyright=

en-aut-name=KinKyohei
en-aut-sei=Kin
en-aut-mei=Kyohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YasuharaTakao
en-aut-sei=Yasuhara
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KamedaMasahiro
en-aut-sei=Kameda
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=DateIsao
en-aut-sei=Date
en-aut-mei=Isao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil= Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil= Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil= Department of Neurological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=animal model
kn-keyword=animal model
en-keyword=alpha-synuclein
kn-keyword=alpha-synuclein
en-keyword=DJ-1
kn-keyword=DJ-1
en-keyword=neurotoxin
kn-keyword=neurotoxin
en-keyword=Parkin
kn-keyword=Parkin
en-keyword=Parkinson's disease
kn-keyword=Parkinson's disease
en-keyword=pesticide
kn-keyword=pesticide
en-keyword=PINK1
kn-keyword=PINK1
en-keyword=1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
kn-keyword=1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
en-keyword=6-hydroxydopamine
kn-keyword=6-hydroxydopamine
END

start-ver=1.4
cd-journal=joma
no-vol=18
cd-vols=
no-issue=2
article-no=
start-page=415
end-page=428
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190713
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Identification of endogenous small peptides involved in rice immunity through transcriptomics- and proteomics-based screening
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Small signalling peptides, generated from larger protein precursors, are important components to orchestrate various plant processes such as development and immune responses. However, small signalling peptides involved in plant immunity remain largely unknown. Here, we developed a pipeline using transcriptomics- and proteomics-based screening to identify putative precursors of small signalling peptides: small secreted proteins (SSPs) in rice, induced by rice blast fungus Magnaporthe oryzae and its elicitor, chitin. We identified 236 SSPs including members of two known small signalling peptide families, namely rapid alkalinization factors and phytosulfokines, as well as many other protein families that are known to be involved in immunity, such as proteinase inhibitors and pathogenesis-related protein families. We also isolated 52 unannotated SSPs and among them, we found one gene which we named immune response peptide (IRP) that appeared to encode the precursor of a small signalling peptide regulating rice immunity. In rice suspension cells, the expression of IRP was induced by bacterial peptidoglycan and fungal chitin. Overexpression of IRP enhanced the expression of a defence gene, PAL1 and induced the activation of the MAPKs in rice suspension cells. Moreover, the IRP protein level increased in suspension cell medium after chitin treatment. Collectively, we established a simple and efficient pipeline to discover SSP candidates that probably play important roles in rice immunity and identified 52 unannotated SSPs that may be useful for further elucidation of rice immunity. Our method can be applied to identify SSPs that are involved not only in immunity but also in other plant functions.
en-copyright=
kn-copyright=

en-aut-name=WangPingyu
en-aut-sei=Wang
en-aut-mei=Pingyu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YaoShaolun
en-aut-sei=Yao
en-aut-mei=Shaolun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KosamiKen-ichi
en-aut-sei=Kosami
en-aut-mei=Ken-ichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=GuoTing
en-aut-sei=Guo
en-aut-mei=Ting
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=LiJing
en-aut-sei=Li
en-aut-mei=Jing
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=ZhangYuanyuan
en-aut-sei=Zhang
en-aut-mei=Yuanyuan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=FukaoYoichiro
en-aut-sei=Fukao
en-aut-mei=Yoichiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=Kaneko-KawanoTakako
en-aut-sei=Kaneko-Kawano
en-aut-mei=Takako
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=ZhangHeng
en-aut-sei=Zhang
en-aut-mei=Heng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SheYi-Min
en-aut-sei=She
en-aut-mei=Yi-Min
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=WangPengcheng
en-aut-sei=Wang
en-aut-mei=Pengcheng
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=XingWeiman
en-aut-sei=Xing
en-aut-mei=Weiman
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

en-aut-name=HanadaKousuke
en-aut-sei=Hanada
en-aut-mei=Kousuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=13
ORCID=

en-aut-name=LiuRenyi
en-aut-sei=Liu
en-aut-mei=Renyi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=14
ORCID=

en-aut-name=KawanoYoji
en-aut-sei=Kawano
en-aut-mei=Yoji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=15
ORCID=

affil-num=1
en-affil=Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences
kn-affil=

affil-num=2
en-affil=Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences
kn-affil=

affil-num=3
en-affil=Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences
kn-affil=

affil-num=4
en-affil=Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences
kn-affil=

affil-num=5
en-affil=Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences
kn-affil=

affil-num=6
en-affil=Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences
kn-affil=

affil-num=7
en-affil=Department of Bioinformatics, Ritsumeikan University
kn-affil=

affil-num=8
en-affil=College of Pharmaceutical Sciences, Ritsumeikan University
kn-affil=

affil-num=9
en-affil=Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences
kn-affil=

affil-num=10
en-affil=Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences
kn-affil=

affil-num=11
en-affil=Shanghai Center for Plant Stress Biology, Center of Excellence for Molecular Plant Sciences, Chinese Academy of Sciences
kn-affil=

affil-num=12
en-affil=Biomolecular Structure and Design, Shanghai Center for Plant Stress Biology
kn-affil=

affil-num=13
en-affil=Department of Bioscience and Bioinformatics, Kyushu Institute of Technology
kn-affil=

affil-num=14
en-affil=Center for Agroforestry Mega Data Science and FAFU-UCR Joint Center for Horticultural Biology and Metabolomics, Haixia Institute of Science and Technology,Fujian Agriculture and Forestry University
kn-affil=

affil-num=15
en-affil=Institute of Plant Science and Resources, Okayama University
kn-affil=
en-keyword=immunity
kn-keyword=immunity
en-keyword=Magnaporthe oryzae
kn-keyword=Magnaporthe oryzae
en-keyword=proteomics
kn-keyword=proteomics
en-keyword=transcriptomics
kn-keyword=transcriptomics
en-keyword=rice
kn-keyword=rice
en-keyword=signalling peptide
kn-keyword=signalling peptide
en-keyword=small secreted protein
kn-keyword=small secreted protein
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=6
article-no=
start-page=063H03
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190629
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Development of a method for measuring rare earth elements in the environment for future experiments with gadolinium-loaded detectors
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Demand to use gadolinium (Gd) in detectors is increasing in the field of elementary particle physics, especially in neutrino measurements and dark matter searches. Large amounts of Gd are used in these experiments. To assess the impact of Gd on the environment it is becoming important to measure the baseline concentrations of Gd. Such measurement, however, is not easy due to interference by other elements. In this paper a method for measuring the concentrations of rare earth elements, including Gd, is proposed. In the method, inductively coupled plasma-mass spectrometry is utilized after collecting the dissolved elements in chelating resin. Results of the ability to detect anomalous concentrations of rare earth elements in river water samples in the Kamioka and Toyama areas are also reported.
en-copyright=
kn-copyright=

en-aut-name=ItoS.
en-aut-sei=Ito
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkadaT.
en-aut-sei=Okada
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TakakuY.
en-aut-sei=Takaku
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HaradaM.
en-aut-sei=Harada
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IkedaM.
en-aut-sei=Ikeda
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KishimotoY.
en-aut-sei=Kishimoto
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KoshioY.
en-aut-sei=Koshio
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=NakahataM.
en-aut-sei=Nakahata
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=NakajimaY.
en-aut-sei=Nakajima
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=SekiyaH.
en-aut-sei=Sekiya
en-aut-mei=H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Okayama University, Faculty of Science
kn-affil=

affil-num=2
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=3
en-affil=Institute for Environmental Sciences, Department of Radioecology
kn-affil=

affil-num=4
en-affil=Okayama University, Faculty of Science
kn-affil=

affil-num=5
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=6
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=7
en-affil=Okayama University, Faculty of Science
kn-affil=

affil-num=8
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=9
en-affil=Kamioka Observatory, Institute for Cosmic Ray Research, University of Tokyo
kn-affil=

affil-num=10
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=5754
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191217
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Elimination of fukutin reveals cellular and molecular pathomechanisms in muscular dystrophy-associated heart failure
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Heart failure is the major cause of death for muscular dystrophy patients, however, the molecular pathomechanism remains unknown. Here, we show the detailed molecular pathogenesis of muscular dystrophy-associated cardiomyopathy in mice lacking the fukutin gene (Fktn), the causative gene for Fukuyama muscular dystrophy. Although cardiac Fktn elimination markedly reduced alpha-dystroglycan glycosylation and dystrophin-glycoprotein complex proteins in sarcolemma at all developmental stages, cardiac dysfunction was observed only in later adulthood, suggesting that membrane fragility is not the sole etiology of cardiac dysfunction. During young adulthood, Fktn-deficient mice were vulnerable to pathological hypertrophic stress with downregulation of Akt and the MEF2-histone deacetylase axis. Acute Fktn elimination caused severe cardiac dysfunction and accelerated mortality with myocyte contractile dysfunction and disordered Golgi-microtubule networks, which were ameliorated with colchicine treatment. These data reveal fukutin is crucial for maintaining myocyte physiology to prevent heart failure, and thus, the results may lead to strategies for therapeutic intervention.
en-copyright=
kn-copyright=

en-aut-name=UjiharaYoshihiro
en-aut-sei=Ujihara
en-aut-mei=Yoshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KanagawaMotoi
en-aut-sei=Kanagawa
en-aut-mei=Motoi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=MohriSatoshi
en-aut-sei=Mohri
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakatsuSatomi
en-aut-sei=Takatsu
en-aut-mei=Satomi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KobayashiKazuhiro
en-aut-sei=Kobayashi
en-aut-mei=Kazuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=TodaTatsushi
en-aut-sei=Toda
en-aut-mei=Tatsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NaruseKeiji
en-aut-sei=Naruse
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KatanosakaYuki
en-aut-sei=Katanosaka
en-aut-mei=Yuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine
kn-affil=

affil-num=3
en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=5
en-affil=Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine
kn-affil=

affil-num=6
en-affil=Division of Neurology/Molecular Brain Science, Kobe University Graduate School of Medicine
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=8
en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=7
article-no=
start-page=783
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190712
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of Lubrication and Forging Load on Surface Roughness, Residual Stress, and Deformation of Cold Forging Tools
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cold forging is a metal forming that which uses localized compressive force at room temperature. During the cold forging process, the tool is subjected to extremely high loads and abrasive wear. Lubrication plays an important role in cold forging to improve product quality and tool life by preventing direct metallic contact. Surface roughness and residual stress also greatly affects the service life of a tool. In this study, variations in surface roughness, residual stress, and specimen deformation with the number of cold forging cycles were investigated under different forging conditions. Specimens that were made of heat-treated SKH51 (59-61 HRC), a high-speed tool steel with a polished working surface, were used. The specimens were subjected to an upsetting process. Compressive residual stress, surface roughness, and specimen deformation showed a positive relationship with the number of forging cycles up to a certain limit and became almost constant in most of the forging conditions. A larger change in residual stress and surface roughness was observed at the center of the specimens in all the forging conditions. The effect of the magnitude of the forging load on the above discussed parameters is large when compared to the effect of the lubrication conditions.
en-copyright=
kn-copyright=

en-aut-name=KarunathilakaNuwan
en-aut-sei=Karunathilaka
en-aut-mei=Nuwan
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TadaNaoya
en-aut-sei=Tada
en-aut-mei=Naoya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=UemoriTakeshi
en-aut-sei=Uemori
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HanamitsuRyota
en-aut-sei=Hanamitsu
en-aut-mei=Ryota
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=FujiiMasahiro
en-aut-sei=Fujii
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=OmiyaYuya
en-aut-sei=Omiya
en-aut-mei=Yuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KawanoMasahiro
en-aut-sei=Kawano
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=Zeno Tech Co., Ltd
kn-affil=
en-keyword=cold forging
kn-keyword=cold forging
en-keyword=high-speed tool steel
kn-keyword=high-speed tool steel
en-keyword=lubrication
kn-keyword=lubrication
en-keyword=residual stress
kn-keyword=residual stress
en-keyword=surface roughness
kn-keyword=surface roughness
en-keyword=tool deformation
kn-keyword=tool deformation
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=12
article-no=
start-page=125317
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191220
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Magnetic characterization change by solvents of magnetic nanoparticles in liquid-phase magnetic immunoassay
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Liquid-phase magnetic immunoassay (MIA) using magnetic nano-particles (MNPs) has been studied as a more rapid method compared to optical methods for inspecting proteins and viruses. MIA can estimate the number of conjugated antibodies without being washed differently from conventional optical immunoassay. However, in the case of the liquid phase, it is considered that the magnetic properties of MNPs are affected by physical properties such as viscosity and impurity substances such as biological substances contained in the blood. In this study, the effect of sodium chloride (NaCl) in buffer and serum solution was evaluated to reveal the effect of serum because the sodium (Na+) and chloride (Cl-) ions in the serum dominate ion balance of blood. The measurement results of AC magnetic susceptibility and a dynamic light scattering (DLS) showed that the aggregation of MNPs was largely affected by the concentration of NaCl. This effect of the NaCl could be explained by shielding of the surface charge of MNPs by ions in the solution. Although the concentrations of NaCl in the buffer and serum solution were almost same, we found that MNPs were aggregated more in their size for those in the serum solution because of other impurities, such as proteins. These results suggest evaluation of effects of the contaminants in serum and optimization of polymer coatings of MNPs could be important factors to realize measurements of magnetic immunoassay with high accuracy. (C) 2019 Author(s).
en-copyright=
kn-copyright=

en-aut-name=JinnoKatsuya
en-aut-sei=Jinno
en-aut-mei=Katsuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HiramatsuBunta
en-aut-sei=Hiramatsu
en-aut-mei=Bunta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=TsunashimaKenta
en-aut-sei=Tsunashima
en-aut-mei=Kenta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FujimotoKayo
en-aut-sei=Fujimoto
en-aut-mei=Kayo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=SakaiKenji
en-aut-sei=Sakai
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KiwaToshihiko
en-aut-sei=Kiwa
en-aut-mei=Toshihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TsukadaKeiji
en-aut-sei=Tsukada
en-aut-mei=Keiji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=4
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=6
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=

affil-num=7
en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=63
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191218
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Breathing chromium spinels: a showcase for a variety of pyrochlore Heisenberg Hamiltonians 
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We address the long-standing problem of the microscopic origin of the richly diverse phenomena in the chromium breathing pyrochlore material family. Combining electronic structure and renormalization group techniques we resolve the magnetic interactions and analyze their reciprocal-space susceptibility. We show that the physics of these materials is principally governed by long-range Heisenberg Hamiltonian interactions, a hitherto unappreciated fact. Our calculations uncover that in these isostructural compounds, the choice of chalcogen triggers a proximity of the materials to classical spin liquids featuring degenerate manifolds of wave-vectors of different dimensions: A Coulomb phase with three-dimensional degeneracy for LiInCr4O8 and LiGaCr4O8, a spiral spin liquid with two-dimensional degeneracy for CuInCr4Se8 and one-dimensional line degeneracies characteristic of the face-centered cubic antiferromagnet for LiInCr4S8, LiGaCr4S8, and CuInCr4S8. The surprisingly complex array of prototypical pyrochlore behaviors we discovered in chromium spinels may inspire studies of transition paths between different semi-classical spin liquids by doping or pressure.
en-copyright=
kn-copyright=

en-aut-name=GhoshPratyay
en-aut-sei=Ghosh
en-aut-mei=Pratyay
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IqbalYasir
en-aut-sei=Iqbal
en-aut-mei=Yasir
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=M?llerTobias
en-aut-sei=M?ller
en-aut-mei=Tobias
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=PonnagantiRavi T.
en-aut-sei=Ponnaganti
en-aut-mei=Ravi T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ThomaleRonny
en-aut-sei=Thomale
en-aut-mei=Ronny
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NarayananRajesh
en-aut-sei=Narayanan
en-aut-mei=Rajesh
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ReutherJohannes
en-aut-sei=Reuther
en-aut-mei=Johannes
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=GingrasMichel J. P.
en-aut-sei=Gingras
en-aut-mei=Michel J. P.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=JeschkeHarald O.
en-aut-sei=Jeschke
en-aut-mei=Harald O.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Department of Physics, Indian Institute of Technology Madras
kn-affil=

affil-num=2
en-affil=Department of Physics, Indian Institute of Technology Madras
kn-affil=

affil-num=3
en-affil=Institute for Theoretical Physics and Astrophysics, Julius-Maximilians-Universit?t W?rzburg
kn-affil=

affil-num=4
en-affil=Department of Physics, Indian Institute of Technology Madras
kn-affil=

affil-num=5
en-affil=Institute for Theoretical Physics and Astrophysics, Julius-Maximilians-Universit?t W?rzburg
kn-affil=

affil-num=6
en-affil=Department of Physics, Indian Institute of Technology Madras
kn-affil=

affil-num=7
en-affil=Dahlem Center for Complex Quantum Systems and Fachbereich Physik, Freie Universit?t Berlin
kn-affil=

affil-num=8
en-affil=Department of Physics and Astronomy, University of Waterloo
kn-affil=

affil-num=9
en-affil=Research Institute for Interdisciplinary Science, Okayama University
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=UNSP 149
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190614
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Organic Matter Preservation and Incipient Mineralization of Microtubules in 120 Ma Basaltic Glass
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Hollow tubular structures in subaqueously-emplaced basaltic glass may represent trace fossils caused by microbially-mediated glass dissolution. Mineralized structures of similar morphology and spatial distribution in ancient, metamorphosed basaltic rocks have widely been interpreted as ichnofossils, possibly dating to similar to 3.5 Ga or greater. Doubts have been raised, however, regarding the biogenicity of the original hollow tubules and granules in basaltic glass. In particular, although elevated levels of biologically-important elements such as C, S, N, and P as well as organic compounds have been detected in association with these structures, a direct detection of unambiguously biogenic organic molecules has not been accomplished. In this study, we describe the direct detection of proteins associated with tubular textures in basaltic glass using synchrotron X-ray spectromicroscopy. Protein-rich organic matter is shown to be associated with the margins of hollow and partly-mineralized tubules. Furthermore, a variety of tubule-infilling secondary minerals, including Ti-rich oxide phases, were observed filling and preserving the microtextures, demonstrating a mechanism whereby cellular materials may be preserved through geologic time.
en-copyright=
kn-copyright=

en-aut-name=IzawaMatthew R. M.
en-aut-sei=Izawa
en-aut-mei=Matthew R. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=DynesJames J.
en-aut-sei=Dynes
en-aut-mei=James J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=BanerjeeNeil R.
en-aut-sei=Banerjee
en-aut-mei=Neil R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FlemmingRoberta L.
en-aut-sei=Flemming
en-aut-mei=Roberta L.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MacLeanLachlan C. W.
en-aut-sei=MacLean
en-aut-mei=Lachlan C. W.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=HetheringtonCallum J.
en-aut-sei=Hetherington
en-aut-mei=Callum J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=MatveevSergei
en-aut-sei=Matveev
en-aut-mei=Sergei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=SouthamGordon
en-aut-sei=Southam
en-aut-mei=Gordon
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=Canadian Light Source, Inc., University of Saskatchewan
kn-affil=

affil-num=3
en-affil=Department of Earth Sciences, University of Western Ontario
kn-affil=

affil-num=4
en-affil=Department of Earth Sciences, University of Western Ontario
kn-affil=

affil-num=5
en-affil=Canadian Light Source, Inc., University of Saskatchewan
kn-affil=

affil-num=6
en-affil=Department of Geosciences, Texas Tech University
kn-affil=

affil-num=7
en-affil=Department of Earth and Atmospheric Sciences, University of Alberta
kn-affil=

affil-num=8
en-affil=Department of Earth Sciences, University of Western Ontario
kn-affil=
en-keyword=ichnofossils
kn-keyword=ichnofossils
en-keyword=biomolecule
kn-keyword=biomolecule
en-keyword=basaltic glass
kn-keyword=basaltic glass
en-keyword=synchrotron XANES
kn-keyword=synchrotron XANES
en-keyword=Ontong Java Plateau
kn-keyword=Ontong Java Plateau
END

start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=
article-no=
start-page=315
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191203
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Titanite Mineralization of Microbial Bioalteration Textures in Jurassic Volcanic Glass, Coast Range Ophiolite, California
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Volcanic glasses are rarely preserved in the rock record, and the quality of preservation generally declines with increasing age. Records preserved in ancient basaltic glasses therefore provide important links between processes operating in the distant past, and those that are active on the Earth today. Microbial colonization has been linked to the formation of characteristic structures in basaltic glass, including tubules and granule-filled tubules, which are thought to be produced by microbially mediated glass dissolution. Structures of similar occurrence and morphology but filled almost entirely with fine-grained titanite have been documented in some ancient metabasalts. It has been suggested that the ancient titanite-mineralized structures are mineralized equivalents of hollow tubules in modern glassy basaltic rocks, but a direct link has not been firmly established. We report the discovery of tubular bioalteration structures in fresh and minimally altered basaltic glasses of middle Jurassic (164 Ma) age from the Stonyford Volcanic Complex (SFVC), Coast Range Ophiolite, California. Tubular structures hosted in unaltered basaltic glass are typically hollow, whilst those in zones of zeolitic alteration are mineralized by titanite. Tubules are continuous across zeolite-glass interfaces, which mark an abrupt change from titanite-filled to hollow tubules, demonstrating that titanite growth occurs preferentially within pre-existing tubular structures. Titanite mineralization in the SFVC represent a link between tubular structures in modern basaltic glass and titanite-mineralized features of similar morphology and spatial distribution in ancient metabasalts. Our observations support a link between textures in modern glassy basaltic rocks and some of the oldest-known putative ichnofossils.
en-copyright=
kn-copyright=

en-aut-name=IzawaMatthew R. M.
en-aut-sei=Izawa
en-aut-mei=Matthew R. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=BanerjeeNeil R.
en-aut-sei=Banerjee
en-aut-mei=Neil R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ShervaisJohn W.
en-aut-sei=Shervais
en-aut-mei=John W.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=FlemmingRoberta
en-aut-sei=Flemming
en-aut-mei=Roberta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HetheringtonCallum J.
en-aut-sei=Hetherington
en-aut-mei=Callum J.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MuehlenbachsKarlis
en-aut-sei=Muehlenbachs
en-aut-mei=Karlis
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SchultzCynthia
en-aut-sei=Schultz
en-aut-mei=Cynthia
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=DasDebarati
en-aut-sei=Das
en-aut-mei=Debarati
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=HananBarry B.
en-aut-sei=Hanan
en-aut-mei=Barry B.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Earth Sciences, University of Western Ontario
kn-affil=

affil-num=3
en-affil=Department of Geology, Utah State University
kn-affil=

affil-num=4
en-affil=Department of Earth Sciences, University of Western Ontario
kn-affil=

affil-num=5
en-affil=Department of Geosciences, Texas Tech University
kn-affil=

affil-num=6
en-affil=Department of Earth and Atmospheric Sciences, University of Alberta
kn-affil=

affil-num=7
en-affil=Department of Geology, San Jose State University
kn-affil=

affil-num=8
en-affil=Institute for Planetary Materials, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Geological Sciences, San Diego State University
kn-affil=
en-keyword=ichnofossil
kn-keyword=ichnofossil
en-keyword=bioalteration
kn-keyword=bioalteration
en-keyword=astrobiology
kn-keyword=astrobiology
en-keyword=basaltic glass
kn-keyword=basaltic glass
en-keyword=titanite
kn-keyword=titanite
END

start-ver=1.4
cd-journal=joma
no-vol=75
cd-vols=
no-issue=
article-no=
start-page=1853
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=201912
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Crystal structure of 4-chloro-2-nitrobenzoic acid with 4-hydroxyquinoline: a disordered structure over two states of 4-chloro-2-nitrobenzoic acid-quinolin-4(1H)-one (1/1) and 4-hydroxyquinolinium 4-chloro-2-nitrobenzoate
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The title compound, C9H7.5NO center dot C7H3.5ClNO4, was analysed as a disordered structure over two states, viz. co-crystal and salt, accompanied by a keto-enol tautomerization in the base molecule. The co-crystal is 4-chloro-2-nitrobenzoic acid-quinolin-4(1H)-one (1/1), C7H4ClNO4 center dot C9H7NO, and the salt is 4-hydroxy-quinolinium 4-chloro-2-nitrobenzoate, C9H8NO+center dot C7H3ClNO4. In the compound, the acid and base molecules are held together by a short hydrogen bond [O center dot center dot center dot O = 2.4393 (15) angstrom], in which the H atom is disordered over two positions with equal occupancies. In the crystal, the hydrogen-bonded acid-base units are linked by N-H center dot center dot center dot O and C-H center dot center dot center dot O hydrogen bonds, forming a tape structure along the a-axis direction. The tapes are stacked into a layer parallel to the ab plane via pi-pi interactions [centroid-centroid distances = 3.5504 (8)-3.9010 (11) angstrom]. The layers are further linked by another C-H center dot center dot center dot O hydrogen bond, forming a three-dimensional network. Hirshfeld surfaces for the title compound mapped over shape-index and d orm were generated to visualize the intermolecular interactions.
en-copyright=
kn-copyright=

en-aut-name=GotohKazuma
en-aut-sei=Gotoh
en-aut-mei=Kazuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=IshidaHiroyuki
en-aut-sei=Ishida
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Department of Chemistry, Faculty of Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Chemistry, Faculty of Science, Okayama University
kn-affil=
en-keyword=crystal structure
kn-keyword=crystal structure
en-keyword=4-chloro-2-nitro-benzoic acid
kn-keyword=4-chloro-2-nitro-benzoic acid
en-keyword=4(1H)-quinolinone
kn-keyword=4(1H)-quinolinone
en-keyword=4-hydroxy-quinoline
kn-keyword=4-hydroxy-quinoline
en-keyword=hydrogen bond
kn-keyword=hydrogen bond
en-keyword=keto-enol tautomerization
kn-keyword=keto-enol tautomerization
en-keyword=Hirshfeld surface
kn-keyword=Hirshfeld surface
END

start-ver=1.4
cd-journal=joma
no-vol=8
cd-vols=
no-issue=12
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191202
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Switching between Three Types of Mesalazine Formulation and Sulfasalazine in Patients with Active Ulcerative Colitis Who Have Already Received High-Dose Treatment with These Agents
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background and aim: Oral mesalazine and sulfasalazine (SASP) are key drugs for treating ulcerative colitis (UC). The efficacy of switching from one of the several mesalazine formulations to another is largely unknown. This study assessed the efficacy of switching among three types of mesalazine formulation and SASP for UC therapy. Methods: UC patients receiving high-dose mesalazine/SASP who switched to other formulations due to disease activity were considered eligible. Efficacy was evaluated 2, 6, and 12 months after switching. Results: A total of 106 switches in 88 UC patients were analyzed. The efficacy at 2 months after switching was observed in 23/39 (59%) cases from any mesalazine formulation to SASP, in 18/55 (33%) cases from one mesalazine to another, and in 2/12 (17%) cases from SASP to any mesalazine formulation. Nine of 43 effective cases showed inefficacy or became intolerant post-switching. Delayed efficacy more than two months after switching was observed in four cases. Steroid-free remission was achieved in 42/106 (39%) cases?within 100 days in 35 of these cases (83%). Conclusions: Switching from mesalazine to SASP was effective in more than half of cases. The efficacy of switching between mesalazine formulations was lower but may be worth attempting in clinical practice from a safety perspective.
en-copyright=
kn-copyright=

en-aut-name=YasutomiEriko
en-aut-sei=Yasutomi
en-aut-mei=Eriko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HiraokaSakiko
en-aut-sei=Hiraoka
en-aut-mei=Sakiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamamotoShumpei
en-aut-sei=Yamamoto
en-aut-mei=Shumpei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkaShohei
en-aut-sei=Oka
en-aut-mei=Shohei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HiraiMami
en-aut-sei=Hirai
en-aut-mei=Mami
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YamasakiYasushi
en-aut-sei=Yamasaki
en-aut-mei=Yasushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=InokuchiToshihiro
en-aut-sei=Inokuchi
en-aut-mei=Toshihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KinugasaHideaki
en-aut-sei=Kinugasa
en-aut-mei=Hideaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=TakaharaMasahiro
en-aut-sei=Takahara
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=HaradaKeita
en-aut-sei=Harada
en-aut-mei=Keita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

en-aut-name=KatoJun
en-aut-sei=Kato
en-aut-mei=Jun
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=11
ORCID=

en-aut-name=OkadaHiroyuki
en-aut-sei=Okada
en-aut-mei=Hiroyuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=12
ORCID=

affil-num=1
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=7
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=8
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=9
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=11
en-affil=Department of Gastroenterology, Graduate School of Medicine, Chiba University
kn-affil=

affil-num=12
en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=ulcerative colitis
kn-keyword=ulcerative colitis
en-keyword=salicylates
kn-keyword=salicylates
en-keyword=mesalazine
kn-keyword=mesalazine
en-keyword=sulfasalazine
kn-keyword=sulfasalazine
END

start-ver=1.4
cd-journal=joma
no-vol=10
cd-vols=
no-issue=
article-no=
start-page=4159
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190913
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Ultrafast isomerization-induced cooperative motions to higher molecular orientation in smectic liquid-crystalline azobenzene molecules
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The photoisomerization of molecules is widely used to control the structure of soft matter in
both natural and synthetic systems. However, the structural dynamics of the molecules
during isomerization and their subsequent response are difficult to elucidate due to their
complex and ultrafast nature. Herein, we describe the ultrafast formation of higherorientation
of liquid-crystalline (LC) azobenzene molecules via linearly polarized ultraviolet
light (UV) using ultrafast time-resolved electron diffraction. The ultrafast orientation is
caused by the trans-to-cis isomerization of the azobenzene molecules. Our observations are
consistent with simplified molecular dynamics calculations that revealed that the molecules
are aligned with the laser polarization axis by their cooperative motion after photoisomerization.
This insight advances the fundamental chemistry of photoresponsive molecules
in soft matter as well as their ultrafast photomechanical applications.
en-copyright=
kn-copyright=

en-aut-name=HadaMasaki
en-aut-sei=Hada
en-aut-mei=Masaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamaguchiDaisuke
en-aut-sei=Yamaguchi
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=IshikawaTadahiko
en-aut-sei=Ishikawa
en-aut-mei=Tadahiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SawaTakayoshi
en-aut-sei=Sawa
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=TsurutaKenji
en-aut-sei=Tsuruta
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshikawaKen
en-aut-sei=Ishikawa
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KoshiharaShin-Ya
en-aut-sei=Koshihara
en-aut-mei=Shin-Ya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=HayashiYasuhiko
en-aut-sei=Hayashi
en-aut-mei=Yasuhiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=KatoTakashi
en-aut-sei=Kato
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

affil-num=1
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Chemistry & Biotechnology, School of Engineering, The University of Tokyo
kn-affil=

affil-num=3
en-affil=School of Science,Tokyo Institute of Technology
kn-affil=

affil-num=4
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=School of Materials and Chemical Technology, Tokyo Institute of Technology
kn-affil=

affil-num=7
en-affil=School of Science,Tokyo Institute of Technology
kn-affil=

affil-num=8
en-affil=Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=9
en-affil=Department of Chemistry & Biotechnology, School of Engineering, The University of Tokyo
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=18
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190911
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Synthesis, Characterization, and In Vivo Anti-Cancer Activity of New Metal Complexes Derived from Isatin-N(4)antipyrinethiosemicarbazone Ligand Against Ehrlich Ascites Carcinoma Cells
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The current study aimed to synthesize new metal coordination complexes with potential biomedical applications. Metal complexes were prepared via the reaction of isatin-N(4)anti- pyrinethiosemicarbazone ligand 1 with Cu(II), Ni(II), Co(II), Zn(II), and Fe(III) ions. The obtained metal complexes 2?12 were characterized using elemental, spectral (1H-NMR, EPR, Mass, IR, UV-Vis) and thermal (TGA) techniques, as well as magnetic moment and molar conductance measurements. In addition, their geometries were studied using EPR and UV?Vis spectroscopy. To evaluate the in vivo anti-cancer activities of these complexes, the ligand 1 and its metal complexes 2, 7 and 9 were tested against solid tumors. The solid tumors were induced by subcutaneous (SC) injection of Ehrlich ascites carcinoma (EAC) cells in mice. The impact of the selected complexes on the reduction of tumor volume was determined. Also, the expression levels of vascular endothelial growth factor (VEGF) and cysteine aspartyl-specific protease-7 (caspase-7) in tumor and liver tissues of mice bearing EAC tumor were determined. Moreover, their effects on alanine transaminase (ALT), aspartate transaminase (AST), albumin, and glucose levels were measured. The results revealed that the tested compounds, especially complex 9, reduced tumor volume, inhibited the expression of VEGF, and induced the expression of caspase-7. Additionally, they restored the levels of ALT, AST, albumin, and glucose close to their normal levels. Taken together, our newly synthesized metal complexes are promising anti-cancer agents against solid tumors induced by EAC cells as supported by the inhibition of VEGF and induction of caspase-7.
en-copyright=
kn-copyright=

en-aut-name=El-SaiedFathy
en-aut-sei=El-Saied
en-aut-mei=Fathy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=El-AaragBishoy
en-aut-sei=El-Aarag
en-aut-mei=Bishoy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SalemTarek
en-aut-sei=Salem
en-aut-mei=Tarek
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SaidGhada
en-aut-sei=Said
en-aut-mei=Ghada
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KhalifaShaden A. M.
en-aut-sei=Khalifa
en-aut-mei=Shaden A. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=El-SeediHesham R.
en-aut-sei=El-Seedi
en-aut-mei=Hesham R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=2
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Molecular Biology, Genetic Engineering & Biotechnology Institute, University of Sadat City
kn-affil=

affil-num=4
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=5
en-affil=Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
kn-affil=

affil-num=6
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
en-keyword=metal complexes
kn-keyword=metal complexes
en-keyword=isatin-N(4)antipyrinethiosemicarbazone
kn-keyword=isatin-N(4)antipyrinethiosemicarbazone
en-keyword=Ehrlich ascites carcinoma
kn-keyword=Ehrlich ascites carcinoma
en-keyword=tumor volume
kn-keyword=tumor volume
en-keyword=VEGF
kn-keyword=VEGF
en-keyword=caspase-7
kn-keyword=caspase-7
END

start-ver=1.4
cd-journal=joma
no-vol=20
cd-vols=
no-issue=20
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191021
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Protective Effects of Flavone from Tamarix aphylla against CCl4-Induced Liver Injury in Mice Mediated by Suppression of Oxidative Stress, Apoptosis and Angiogenesis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The current study aimed to investigate, for the first time, the beneficial effects of 3,5-dihydroxy-4′,7-dimethoxyflavone isolated from Tamarix aphylla L. against liver injury in mice. Liver injury was induced by intraperitoneal (i.p.) injection of carbon tetrachloride (CCl4) at a dose of 0.4 mL/kg mixed in olive oil at ratio (1:4) twice a week for 6 consecutive weeks. The administration of CCl4 caused significant histopathological changes in liver tissues while the pre-treatment with the flavone at dose of 10 and 25 mg/kg ameliorated the observed liver damages. Also, it markedly reduced hepatic malondialdehyde (MDA) level as well as increased the activities of liver superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) compared with their recorded levels in CCl4 model group. Moreover, the immunohistochemical analysis demonstrated the enhancement in the protein level of B-cell lymphoma-2 (Bcl-2) while the protein levels of cysteine-aspartic acid protease-3 (caspase-3), Bcl-2-associated x protein (Bax), transforming growth factor-β1 (TGF-β1) and CD31 were suppressed following the flavone treatement. These results suggest that the flavone can inhibit liver injury induced in mice owning to its impact on the oxidation, apoptotic and angiogenesis mechanisms. Further pharmacological investigations are essential to determine the effectiveness of the flavone in human.
en-copyright=
kn-copyright=

en-aut-name=El-AaragBishoy
en-aut-sei=El-Aarag
en-aut-mei=Bishoy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KhairyAsmaa
en-aut-sei=Khairy
en-aut-mei=Asmaa
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KhalifaShaden A. M.
en-aut-sei=Khalifa
en-aut-mei=Shaden A. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=El-SeediHesham R.
en-aut-sei=El-Seedi
en-aut-mei=Hesham R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Chemistry Department, Faculty of Science, Menoufia University
kn-affil=

affil-num=3
en-affil=Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
kn-affil=

affil-num=4
en-affil=Chemistry Department, Faculty of Science, Menoufia University
kn-affil=
en-keyword=liver injury
kn-keyword=liver injury
en-keyword=CCl4
kn-keyword=CCl4
en-keyword=Tamarix aphylla
kn-keyword=Tamarix aphylla
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=apoptosis
kn-keyword=apoptosis
en-keyword=angiogenesis
kn-keyword=angiogenesis
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=裏表紙・英文目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=奥付
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=186
end-page=195
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of self-assessment sheet for Non-cognitive skills
kn-title=非認知能力に関する自己評価シートの開発
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　定量化による測定が困難とされる非認知能力に関して、自己評価による測定を試みるべく、その評価シートの開発を3 つの段階を踏まえて精緻に行った。特に本研究では、非認知能力との親和性が高いキャリア教育に着目して、キャリア教育の一環として正課外活動（ 主に校友会クラブ活動）の支援に取り組む岡山大学の学生を予備調査の対象とした。当該学生たちによって予備調査用の質問項目を選定し、仮質問調査のための質問項目を精査した上で、まだ正課外活動に携わる前段階の年度当初の1 学年の学生へ仮質問調査を行った。この仮質問調査の結果を分析して、3 能力群各5 項目、計15 項目の非認知能力に関する自己評価シートを開発することができた。
en-copyright=
kn-copyright=

en-aut-name=NAKAYAMAYoshikazu
en-aut-sei=NAKAYAMA
en-aut-mei=Yoshikazu
kn-aut-name=中山芳一
kn-aut-sei=中山
kn-aut-mei=芳一
aut-affil-num=1
ORCID=

en-aut-name=YOSHIZAWAEri
en-aut-sei=YOSHIZAWA
en-aut-mei=Eri
kn-aut-name=吉澤英里
kn-aut-sei=吉澤
kn-aut-mei=英里
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学キャリア開発センター

affil-num=2
en-affil=
kn-affil=
en-keyword=非認知能力
kn-keyword=非認知能力
en-keyword=自己評価シート
kn-keyword=自己評価シート
en-keyword=自己維持・調整能力群
kn-keyword=自己維持・調整能力群
en-keyword=自己変革・向上能力群
kn-keyword=自己変革・向上能力群
en-keyword=他者協調・ 協働能力群
kn-keyword=他者協調・ 協働能力群
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=168
end-page=185
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=What Should International Student Dormitories Be at Okayama University？: Current State and Issues of the International Student Shared House and Other Dormitories
kn-title=岡山大学における留学生宿舎の在り方 : 国際学生シェアハウスの実態と課題を中心に
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 岡山大学の留学生宿舎の36 年の歴史の中で、寮規則の遵守、人間関係の構築、施設や人的リソース不足など多種多様な課題が指摘されてきた。3 年前に開所した混住型の国際学生シェアハウスにおいて新たに日本人学生が関与する問題が追加発生したこともあり、教育資源として寮を活用する視点から一転して、効率化のために管理を外注化する方向に舵を切った。留学生活の基盤となる住環境を整えることは元来、費用や労力のかかることであり、日常的に起こる課題を解決するためには、責任感のあるリーダー的日本人学生の果たす役割が小さくない。その一方で、課題解決できる日本人学生の育成には、きめ細かい指導・助言に加えて、教育資源としての寮の活用という大学のビジョンと推進力が必要である。
en-copyright=
kn-copyright=

en-aut-name=UZUKAMariko
en-aut-sei=UZUKA
en-aut-mei=Mariko
kn-aut-name=宇塚万里子
kn-aut-sei=宇塚
kn-aut-mei=万里子
aut-affil-num=1
ORCID=

en-aut-name=OKAMasumi
en-aut-sei=OKA
en-aut-mei=Masumi
kn-aut-name=岡益巳
kn-aut-sei=岡
kn-aut-mei=益巳
aut-affil-num=2
ORCID=

en-aut-name=FUJIMOTOMasumi
en-aut-sei=FUJIMOTO
en-aut-mei=Masumi
kn-aut-name=藤本真澄
kn-aut-sei=藤本
kn-aut-mei=真澄
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学言語教育センター

affil-num=2
en-affil=
kn-affil=岡山大学名誉教授

affil-num=3
en-affil=
kn-affil=岡山大学全学教育・学生支援機構
en-keyword=国際シェアハウス
kn-keyword=国際シェアハウス
en-keyword=ユニットリーダー
kn-keyword=ユニットリーダー
en-keyword=フロアリーダー
kn-keyword=フロアリーダー
en-keyword=異文化理解
kn-keyword=異文化理解
en-keyword=教育資源
kn-keyword=教育資源
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=149
end-page=167
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Outline of the High School Trial Corresponding to the University Entrance Selection Reform : Special Examination Subcommittee of the National Six University Collaborative Consortium Education Collaboration Organization
kn-title=大学入学者選抜改革に対応する高校トライアルの概要について : 国立六大学連携コンソーシアム教育連携機構入試専門部会事業
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 6 大学連携事業として，評価したい資質について掘り下げ質問を行う構造化面接と，面接に代わる筆記試験であるペーパーインタビューについて，県内の高等学校の協力を得て2019 年度にトライアルを行った。評価した資質は「新たなこと追究しようとする態度」と「協働して取り組む態度」であり，まず，構造化面接とペーパーインタビューの結果を本学の教員が評価し，その結果を高校教員が個々の受験生に抱いている日常的評価と比較した。トライアルの結果，構造化面接の有効性ならびに，受験者全員に面接を課すことが，時間的，人員的に実施困難な入試におけるペーパーインタビューの有効性が確認された。同時に，測ろうとする資質によっては，面接との評価結果が異なる部分があることも明らかとなった。
en-copyright=
kn-copyright=

en-aut-name=ISHIIIchiro
en-aut-sei=ISHII
en-aut-mei=Ichiro
kn-aut-name=石井一郎
kn-aut-sei=石井
kn-aut-mei=一郎
aut-affil-num=1
ORCID=

en-aut-name=HARADAKazuyuki
en-aut-sei=HARADA
en-aut-mei=Kazuyuki
kn-aut-name=原田和往
kn-aut-sei=原田
kn-aut-mei=和往
aut-affil-num=2
ORCID=

en-aut-name=KAMIMURAHiroko
en-aut-sei=KAMIMURA
en-aut-mei=Hiroko
kn-aut-name=上村弘子
kn-aut-sei=上村
kn-aut-mei=弘子
aut-affil-num=3
ORCID=

en-aut-name=MONTAMitsuji
en-aut-sei=MONTA
en-aut-mei=Mitsuji
kn-aut-name=門田充司
kn-aut-sei=門田
kn-aut-mei=充司
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学

affil-num=2
en-affil=
kn-affil=岡山大学大学院社会文化科学研究科

affil-num=3
en-affil=
kn-affil=岡山大学大学院教育学研究科

affil-num=4
en-affil=
kn-affil=岡山大学大学院環境生命科学研究科
en-keyword=学力の三要素
kn-keyword=学力の三要素
en-keyword=構造化面接
kn-keyword=構造化面接
en-keyword=ペーパーインタビュー
kn-keyword=ペーパーインタビュー
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=134
end-page=148
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=A Study on the Influence of Positive Perception towards Organisations: The Case of Japanese Aid Projects
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= This study attempts to develop a management model at cross-cultural work environment, which explains how managers’ perception affects their organisational performance. The model is created based on findings of quantitative research conducted toward Japanese aid project managers working in developing countries. As a result of cluster analysis, four types of aid project managers were identified. The model clarified how four types of aid project managers perceive, behave and consequently lead to either high or low performance organisation. Finally, this study indicates that fostering and maintaining positive perception are a key for successful organisation.
en-copyright=
kn-copyright=

en-aut-name=INAMORITakao
en-aut-sei=INAMORI
en-aut-mei=Takao
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学グローバル人材育成院
en-keyword=managerial perception
kn-keyword=managerial perception
en-keyword=organisational performance
kn-keyword=organisational performance
en-keyword=cross-cultural work environment
kn-keyword=cross-cultural work environment
en-keyword=Pygmalion effect
kn-keyword=Pygmalion effect
en-keyword=Golem effect.
kn-keyword=Golem effect.
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=124
end-page=133
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Enhancing Japanese Student Engagement: The Voice of Experience
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Okayama University has seen recently an upsurge in the number of courses taught in English. While students generally like the English-medium courses for the abundance and novelty of information available in them, they tend to show hesitance to participate, which sometimes leads to dissatisfaction with the courses. International faculty members also feel something is amiss because they do not understand why students fail to be responsive. Clearly, enhancement of student participation and mitigation of the alienating teaching experience of international faculty are challenges to effective administration of global studies. To that end, the quiet cultivation of optimal demographics for Englishmedium courses is currently the most effective strategy.
en-copyright=
kn-copyright=

en-aut-name=KIMDong Kwang
en-aut-sei=KIM
en-aut-mei=Dong Kwang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Institute for Global Human Resource Development, Okayama University
kn-affil=
en-keyword=global studies
kn-keyword=global studies
en-keyword=English-medium courses
kn-keyword=English-medium courses
en-keyword=Japanese student participation
kn-keyword=Japanese student participation
en-keyword=international faculty experience
kn-keyword=international faculty experience
en-keyword=factors enhancing participation
kn-keyword=factors enhancing participation
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=112
end-page=123
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Who Cares ? Reflections on an International Multidisciplinary Symposium on Care Economy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=One of the targets under the Sustainable Development Goals (SDGs) aims to reduce and redistribute unpaid care work, which is mostly done by women, through the provision of public services and the promotion of shared responsibility. In February 2019, experts from academia and international organizations gathered at Okayama University for an international symposium focused on the issues around unpaid and paid care work in relation to gender equality and sustainable society. This paper will first briefly summarize the issues in care work, with a focus on childcare and elderly care in a Japanese context, followed by a discussion of the key points from the symposium related to care-centered economic and social policies.
en-copyright=
kn-copyright=

en-aut-name=YAMAMOTOYumiko
en-aut-sei=YAMAMOTO
en-aut-mei=Yumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Institute for Education and Student Services,  Okayama University
kn-affil=
en-keyword=Care
kn-keyword=Care
en-keyword=aging
kn-keyword=aging
en-keyword=gender
kn-keyword=gender
en-keyword=Japan
kn-keyword=Japan
en-keyword=SDGs
kn-keyword=SDGs
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=101
end-page=111
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Impact of Topic Selection on the Use of Viewpoint Expressions An Analysis of Native Japanese Speaker Narratives
kn-title=視点表現の使用にトピックが与える影響 : 日本語母語話者のナラティヴの分析を通して
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 本研究では、日本語母語話者11 名に10 のトピックに関するパーソナル・ナラティヴを実施し、視点表現の出現傾向について分析を行った。分析の結果、日本語教科書で、迷惑や被害を表す表現として導入される受身表現に加え、移動表現についても他者から受けた不快な行為を描写する際に用いられることが分かった。また、使役表現は、典型的な強制の意味よりは、授受表現「てもらう」との組み合わせで感謝を示す際に用いられていた。以上の結果から、教科書で視点表現が扱われているトピックと日本語母語話者の使用が認められたものが必ずしも一致しないことが示された。
en-copyright=
kn-copyright=

en-aut-name=SUESHIGEMiwa
en-aut-sei=SUESHIGE
en-aut-mei=Miwa
kn-aut-name=末繁美和
kn-aut-sei=末繁
kn-aut-mei=美和
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学全学教育・学生支援機構
en-keyword=視点表現
kn-keyword=視点表現
en-keyword=トピック
kn-keyword=トピック
en-keyword=ナラティヴ
kn-keyword=ナラティヴ
en-keyword=日本語母語話者
kn-keyword=日本語母語話者
en-keyword=日本語教科書
kn-keyword=日本語教科書
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=88
end-page=100
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Selection and Evaluation of Extensive Reading Books by Japanese Language Learners
kn-title=日本語学習者による多読用書籍の選書とその評価
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 本稿では，著者の所属する大学で開講された多読クラスの概要を紹介するとともに，その授業の履修者107 名の読書記録から，彼らの選書傾向，本の理解度，面白さの評価を報告する。履修者は授業が進むにつれ，段階的読み物から日本語母語話者用の読み物を読む割合が増えていった。また，理解度については，段階別読み物の理解度が高く，日本語母語話者向けの本の中では絵本の理解度が高かった。さらに，面白さについては，漫画の評価が最も高かった。データからはまた，日本語力の低い学習者には母語話者向けの本は適切な多読教材とは言い難いこと，今後日本語学習者のための多読教材を質量両面での充実する必要性があることも示唆された。
en-copyright=
kn-copyright=

en-aut-name=BannoEri
en-aut-sei=Banno
en-aut-mei=Eri
kn-aut-name=坂野永理
kn-aut-sei=坂野
kn-aut-mei=永理
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学全学教育・学生支援機構
en-keyword=多読
kn-keyword=多読
en-keyword=日本語学習者
kn-keyword=日本語学習者
en-keyword=書籍
kn-keyword=書籍
en-keyword=理解度
kn-keyword=理解度
en-keyword=面白さ
kn-keyword=面白さ
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=72
end-page=87
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Study on the Korean Sentences in "Korinsuchi" published in Early Meiji Era
kn-title=明治前期に刊行された『交隣須知』の韓国語文の比較研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 本稿では、明治前期に刊行された明治14年刊『交隣須知』(初刊本)、明治16年刊『再刊交隣須知』(再刊本)、白石氏蔵版『交隣須知』(宝迫本)の3本における韓国語文を対象に、初刊本と再刊本、初刊本と宝迫本の韓国語文の違いを調べる。分析結果をみると、�@ 初刊本から再刊本においては、韓国語文の誤りを訂正したものの、大多数の韓国語文は同じであること、�A 初刊本と宝迫本においては、宝迫本には初刊本と違って見出し語がなく、対訳の日本語文を上段に示し、また韓国語文の変化が多いことがわかる。この研究は交隣須知関する基礎研究であり、今後明治期の朝鮮語学習書に関する研究に役立つと考えられる。
en-copyright=
kn-copyright=

en-aut-name=JINNamtaek
en-aut-sei=JIN
en-aut-mei=Namtaek
kn-aut-name=陳南澤
kn-aut-sei=陳
kn-aut-mei=南澤
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学 全学教育・学生支援機構 基幹教育センター
en-keyword=朝鮮語学習書
kn-keyword=朝鮮語学習書
en-keyword=交隣須知刊行本
kn-keyword=交隣須知刊行本
en-keyword=浦瀬裕
kn-keyword=浦瀬裕
en-keyword=宝迫繁勝
kn-keyword=宝迫繁勝
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=50
end-page=71
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Discovery Program for Global Learners at Okayama University
kn-title=「此の高価なレッスン」 : 東日本大震災を「わすれン！」
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=ChungHaeng-ja
en-aut-sei=Chung
en-aut-mei=Haeng-ja
kn-aut-name=鄭幸子
kn-aut-sei=鄭
kn-aut-mei=幸子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学 グローバル人材育成院 
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=38
end-page=49
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of Academic Japanese Training Course for Students at the Discovery Program for Global Learners, Okayama University
kn-title=「アカデミック・ジャパニーズ・トレーニング」コース開発  : 岡山大学グローバル・ディスカバリー・プログラムにおける取り組み
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= 岡山大学グローバル・ディスカバリー・プログラムは英語だけで学位が取れる新しいプログラムであるが, 制度上他学部開講の授業も履修することが可能である。全学日本語の日本語コースで日本語「を」学ぶ学生とともに他学部で日本語「で」学ぶディスカバリー生も徐々に増えている。そこで他学部の授業や教養科目を履修するディスカバリー生を対象にアカデミック・ジャパニーズ科目を新規開講することになった。Backward Design，Differentiated Instruction，Learning Strategy Instruction の手法を利用し，授業をこなし単位を取得することを目標に，学生が限られた日本語能力で最大限に対応できる「自分に合う」学習ストラテジーを開拓できるコースの開発と履修状況を報告する。
en-copyright=
kn-copyright=

en-aut-name=USHIDAEiko
en-aut-sei=USHIDA
en-aut-mei=Eiko
kn-aut-name=牛田英子
kn-aut-sei=牛田
kn-aut-mei=英子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学 グローバル人材育成
en-keyword=グローバル・ディスカバリー・プログラム
kn-keyword=グローバル・ディスカバリー・プログラム
en-keyword=アカデミック・ジャパニーズ
kn-keyword=アカデミック・ジャパニーズ
en-keyword=Backward Design
kn-keyword=Backward Design
en-keyword=Differentiated Instruction
kn-keyword=Differentiated Instruction
en-keyword=学習ストラテジー
kn-keyword=学習ストラテジー
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=31
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Backgrounds and Characteristics of IB Students Enrolled at Okayama University: A 7-year Experience
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The number of International Baccalaureate (IB) students applying to Japanese Universities is increasing. Okayama University is a Super Global Japanese National University which started IB admissions in 2012, and presently has 50 IB students in 11 faculties and 1 special program, in addition to 4 IB graduates. The IB journey began in 2012, and over a period of 7 years, Okayama University has taken multiple approaches to become IB student-friendly, by revising the IB admission policies as per IB student requirements; training faculty on IB education; exploring the differences in IB education and Japanese High School education; listening to IB student voices and familiarizing faculty about IB student backgrounds and characteristics. By providing IB student support, educating faculty and doing extensive IB research, Okayama University has established itself as a pioneer of IB admissions among the IB Organization, prospective IB students and parents, IB college counselors and other National Universities in Japan.
en-copyright=
kn-copyright=

en-aut-name=MAHMOODSabina
en-aut-sei=MAHMOOD
en-aut-mei=Sabina
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学 全学教育・学生支援機構
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=11
end-page=30
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=ZAINICHI KOREANS’ ETHNIC IDENTITIES AND ROLES OF ETHNIC ORGANISATION AND COMMUNITY
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= This paper discusses how Zainichi Koreans developed their identities both within and outside the realm of the ethnic community and ethnic organisations. This study uses qualitative multimethods research based on interviews with members and non-members of Zainichi Koirean organisations and field observations. The examination on Zainichi Koirean organisation members mainly concentrates on lived experiences of members from one of the ethnic organisations of Zainichi Koreans, Chongryun. This study finds that although some young Koreans separate themselves from the organisation and the homeland, they remain in the community. Many Chongryun Koreans share a collective ethnic consciousness, which was based on members’ love for the Chongryun schools. While there is an internal division within the community in terms of political views, many members still have a strong sense of group solidarity. On the other hand, the identities of non-member respondents are remarkably diverse. While some of them are assimilated into Japanese society, others retain strong ethnic identities. Their identities are less affected by any ethnic organisations and they rarely share collective memories with other Zainichi Koreans. This study shows that social networks and experiences of ethnic community individuals have a key role in determining their identities and the ways in which they live their lives.
en-copyright=
kn-copyright=

en-aut-name=WICKSTRUMYuuka
en-aut-sei=WICKSTRUM
en-aut-mei=Yuuka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学 全学教育・学生支援機構
en-keyword=Zainichi Koreans
kn-keyword=Zainichi Koreans
en-keyword=ethnic associations
kn-keyword=ethnic associations
en-keyword=ethnic community
kn-keyword=ethnic community
en-keyword=collective identity
kn-keyword=collective identity
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=1
end-page=10
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Practice of Academic Writing Course using LMS
kn-title=LMS を活用したアカデミック・ライティング科目の授業実践
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　本稿では、LMS を活用したアカデミック・ライティング科目の実践例を報告し、ライティング支援に関する今後の方向性等について検討した。本授業でのLMS 活用内容は主に、�@資料（授業スライドおよび参考資料）の配布、�A授業時の課題・コメント収集、�B原稿（草稿、第一次原稿、最終原稿等）の提出およびフィードバック、の3 点であった。LMS の活用は、授業内外において学生と教員とのコミュニケーションを活発にし、ライティング課題の作成を円滑に進めるうえで極めて有効であったが、教員側がある程度、LMS 活用能力を備えていなければならず、また、コース作成の労力もそれなりにかかるため、今後、より多くのアカデミック・ライティング担当教員にLMS を活用してもらうためには、こうした課題を克服していく必要があると考えられる。
en-copyright=
kn-copyright=

en-aut-name=KOBAYASHIYuji
en-aut-sei=KOBAYASHI
en-aut-mei=Yuji
kn-aut-name=小林雄志
kn-aut-sei=小林
kn-aut-mei=雄志
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学 全学教育・学生支援機構
en-keyword=アクティブラーニング
kn-keyword=アクティブラーニング
en-keyword=ライティング能力育成
kn-keyword=ライティング能力育成
en-keyword=学習支援
kn-keyword=学習支援
en-keyword=授業時間外学修
kn-keyword=授業時間外学修
en-keyword=Moodle
kn-keyword=Moodle
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=8
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190416
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Melittin Exerts Beneficial Effects on Paraquat-Induced Lung Injuries in Mice by Modifying Oxidative Stress and Apoptosis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Melittin (MEL) is a 26-amino acid peptide with numerous biological activities. Paraquat (PQ) is one of the most widely used herbicides, although it is extremely toxic to humans. To date, PQ poisoning has no effective treatment, and therefore the current study aimed to assess for the first time the possible effects of MEL on PQ-induced lung injuries in mice. Mice received a single intraperitoneal (IP) injection of PQ (30 mg/kg), followed by IP treatment with MEL (0.1 and 0.5 mg/kg) twice per week for four consecutive weeks. Histological alterations, oxidative stress, and apoptosis in the lungs were studied. Hematoxylin and eosin (H&E) staining indicated that MEL markedly reduced lung injuries induced by PQ. Furthermore, treatment with MEL increased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity, and decreased malonaldehyde (MDA) and nitric oxide (NO) levels in lung tissue homogenates. Moreover, immunohistochemical staining showed that B-cell lymphoma-2 (Bcl-2) and survivin expressions were upregulated after MEL treatment, while Ki-67 expression was downregulated. The high dose of MEL was more effective than the low dose in all experiments. In summary, MEL efficiently reduced PQ-induced lung injuries in mice. Specific pharmacological examinations are required to determine the effectiveness of MEL in cases of human PQ poisoning.
en-copyright=
kn-copyright=

en-aut-name=El-AaragBishoy
en-aut-sei=El-Aarag
en-aut-mei=Bishoy
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=MagdyMohamed
en-aut-sei=Magdy
en-aut-mei=Mohamed
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=AlAjmiMohamed F.
en-aut-sei=AlAjmi
en-aut-mei=Mohamed F.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KhalifaShaden A. M.
en-aut-sei=Khalifa
en-aut-mei=Shaden A. M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=El-SeediHesham R.
en-aut-sei=El-Seedi
en-aut-mei=Hesham R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=

affil-num=3
en-affil=Department of Pharmacognosy, College of Pharmacy, King Saud University
kn-affil=

affil-num=4
en-affil=Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University
kn-affil=

affil-num=5
en-affil=Department of Chemistry, Faculty of Science, Menoufia University
kn-affil=
en-keyword=paraquat
kn-keyword=paraquat
en-keyword=lung injury
kn-keyword=lung injury
en-keyword=melittin
kn-keyword=melittin
en-keyword=oxidative stress
kn-keyword=oxidative stress
en-keyword=apoptosis
kn-keyword=apoptosis
END

start-ver=1.4
cd-journal=joma
no-vol=4
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191230
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=表紙・目次
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=
END

start-ver=1.4
cd-journal=joma
no-vol=24
cd-vols=
no-issue=11
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190605
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel. 
en-copyright=
kn-copyright=

en-aut-name=WangNing
en-aut-sei=Wang
en-aut-mei=Ning
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=?witalskaMarta
en-aut-sei=?witalska
en-aut-mei=Marta
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=WangLi 
en-aut-sei=Wang
en-aut-mei=Li 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=ShabanElkhabiry
en-aut-sei=Shaban
en-aut-mei=Elkhabiry
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HossainMd Imran
en-aut-sei=Hossain
en-aut-mei=Md Imran
kn-aut-name=  
kn-aut-sei=
kn-aut-mei=  
aut-affil-num=5
ORCID=

en-aut-name=El SayedIbrahim El Tantawy 
en-aut-sei=El Sayed
en-aut-mei=Ibrahim El Tantawy 
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=WietrzykJoanna
en-aut-sei=Wietrzyk
en-aut-mei=Joanna
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=InokuchiTsutomu
en-aut-sei=Inokuchi
en-aut-mei=Tsutomu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=2
en-affil=Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
kn-affil=

affil-num=3
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=4
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=5
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=6
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=

affil-num=7
en-affil=Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
kn-affil=

affil-num=8
en-affil=Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University
kn-affil=
en-keyword=cryptolepine
kn-keyword=cryptolepine
en-keyword=neocryptolepine
kn-keyword=neocryptolepine
en-keyword=isocryptolepine
kn-keyword=isocryptolepine
en-keyword=antiproliferative activity
kn-keyword=antiproliferative activity
en-keyword=structure activity relationships
kn-keyword=structure activity relationships
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=21
article-no=
start-page=E4252
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191101
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Quasi-Randomized Trial of Effects of Perioperative Oral Hygiene Instruction on Inpatients with Heart Diseases Using a Behavioral Six-Step Method
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The assessor-blinded, parallel-design, quasi-randomized study (alternating allocation) aimed to determine the effects of the six-step method on postoperative numbers of oral bacteria, periodontal status, and atrial fibrillation (AF) among inpatients with heart diseases and periodontitis. Seventy inpatients who received preoperative periodontal treatment were quasi-randomly assigned to intervention and control groups at University Hospital. The intervention group received intensive oral hygiene instruction using a six-step method for 15 minutes per week and the control group received routine oral hygiene instruction. Significantly fewer oral bacteria were identified on the tongue at discharge compared with baseline in the intervention than the control group (ANCOVA) (large effect size, p = 0.02). Changes in scores for self-efficacy, plaque scores, probed pocket depth, and bleeding on probing between baseline and discharge were significantly greater in the intervention, than in the control group (p < 0.05). The period of postoperative AF (days) was significantly shorter in the intervention, than in the control group (p = 0.019). In conclusion, oral hygiene instruction using the six-step method decreased the numbers of oral bacteria on the tongue and improved self-efficacy, oral health behaviors, oral hygiene status, periodontal status, and period of postoperative AF among inpatients with periodontitis and heart diseases.
en-copyright=
kn-copyright=

en-aut-name=OmoriChie
en-aut-sei=Omori
en-aut-mei=Chie
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EkuniDaisuke
en-aut-sei=Ekuni
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OhbayashiYumiko
en-aut-sei=Ohbayashi
en-aut-mei=Yumiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=MiyakeMinoru
en-aut-sei=Miyake
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MoritaManabu
en-aut-sei=Morita
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil= Department of Preventive Dentistry, Okayama University graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil= Department of Preventive Dentistry, Okayama University graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Oral and Maxillofacial Surgery, Kagawa University Hospital
kn-affil=

affil-num=4
en-affil=Department of Oral and Maxillofacial Surgery, Kagawa University Hospital
kn-affil=

affil-num=5
en-affil= Department of Preventive Dentistry, Okayama University graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=oral hygiene instruction
kn-keyword=oral hygiene instruction
en-keyword=perioperative period
kn-keyword=perioperative period
en-keyword=self-efficacy
kn-keyword=self-efficacy
en-keyword=six-step method
kn-keyword=six-step method
END

start-ver=1.4
cd-journal=joma
no-vol=9
cd-vols=
no-issue=4
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191218
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Liver transplantation in a patient with hereditary haemorrhagic telangiectasia and pulmonary hypertension
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Hereditary haemorrhagic telangiectasia or Rendu-Osler-Weber syndrome is a systemic vascular disease with autosomal dominant inheritance, mucocutaneous telangiectasia, and repeated nasal bleeding due to vascular abnormalities. Hereditary haemorrhagic telangiectasia may occasionally lead to complications, including arteriovenous malformations and pulmonary hypertension. We present a case of a 52-year-old female patient with hereditary haemorrhagic telangiectasia who was referred to our hospital for treatment of pulmonary hypertension. She had been diagnosed with hereditary haemorrhagic telangiectasia during adolescence and was being followed up. Six months prior to presentation, she had undergone coil embolization for pulmonary haemorrhage due to pulmonary arteriovenous malformations. She was in World Health Organization functional class IV, with a mean of pulmonary arterial pressure of 38 mmHg, a pulmonary capillary wedge pressure of 10 mmHg, and a right atrial pressure of 22 mmHg. A contrast-enhanced computed tomography angiography showed large arteriovenous malformations in the liver. Right heart catheterization revealed an increase in oxygen saturation in the inferior vena cava between the supra- and infra-hepatic veins, low pulmonary vascular resistance, and high right atrial pressure. Hence, she was diagnosed with hereditary haemorrhagic telangiectasia with pulmonary hypertension due to major arteriovenous shunt resulting from arteriovenous malformations in the liver. Therefore, we considered liver transplantation as an essential treatment option. She underwent cadaveric liver transplantation after a year resulting in dramatic haemodynamic improvement to World Health Organization functional class I. Liver transplantation is a promising treatment in patients with hereditary haemorrhagic telangiectasia and pulmonary hypertension resulting from arteriovenous shunt caused by arteriovenous malformations in the liver.
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=EjiriKentaro
kn-aut-sei=Ejiri
kn-aut-mei=Kentaro
aut-affil-num=1
ORCID=

en-aut-name=AkagiSatoshi
en-aut-sei=Akagi
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamuraKazufumi
en-aut-sei=Nakamura
en-aut-mei=Kazufumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=AmiokaNaofumi
en-aut-sei=Amioka
en-aut-mei=Naofumi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IchikawaKeishi
en-aut-sei=Ichikawa
en-aut-mei=Keishi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=ItoHiroshi
en-aut-sei=Ito
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=6
en-affil=Department of Hepato-Biliary-Pancreatic Surgery, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Rendu-Osler-Weber syndrome
kn-keyword=Rendu-Osler-Weber syndrome
en-keyword=arteriovenous malformation
kn-keyword=arteriovenous malformation
en-keyword=pulmonary haemorrhage
kn-keyword=pulmonary haemorrhage
END

start-ver=1.4
cd-journal=joma
no-vol=5
cd-vols=
no-issue=4
article-no=
start-page=551
end-page=560
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190923
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Separation Between Silicon and Aluminum Powders Contained Within Pulverized Scraped Silicon-Based Waste Solar Cells by Flotation Method
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= There are few study examples on the separation of metals by floating method. In this study, separation of silicon and aluminum, which are the main components of silicon-based solar cell module, was carried out by floating method in order to purify silicon from waste solar cell module. The selection of surfactant, control of electric charge, wettability of the solid particles, surface tensions, and bubble surface area are important for separation of solids by floating method. Sodium dodecyl sulfate (SDS) can increase the hydrophobicity of aluminum powder due to the difference of surface potentials between silicon and aluminum. SDS behaves as a collector of aluminum as well as a frothing agent to decrease the bubble size. At a SDS concentration of 2 g/L and sample dipping time of 10 min, 80.1 mass% of aluminum was floated and separated, and the sedimentary silicon reached a purity of 90.7% from a mixture of 50 mass% aluminum and 50 mass% silicon. Finally, at a pH value of 7.0, SDS concentration between 1.0 and 2.5 g/L and air flow rate of 2.5 L/min (STP) were suitable experimental conditions to purify silicon from a mixture of silicon and aluminum by flotation separation method.
en-copyright=
kn-copyright=

en-aut-name=HaradaSho
en-aut-sei=Harada
en-aut-mei=Sho
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UddinMd. Azhar
en-aut-sei=Uddin
en-aut-mei=Md. Azhar
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KatoYoshiei
en-aut-sei=Kato
en-aut-mei=Yoshiei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawanishiTakanori
en-aut-sei=Kawanishi
en-aut-mei=Takanori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=HayashiYoshiaki
en-aut-sei=Hayashi
en-aut-mei=Yoshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Material and Energy Science, Graduate School of Environmental and Life Science, Okayama University
kn-affil=

affil-num=4
en-affil=Wet Process Division, Toho Kasei Co., Ltd
kn-affil=

affil-num=5
en-affil=Wet Process Division, Toho Kasei Co., Ltd
kn-affil=
en-keyword=Flotation
kn-keyword=Flotation
en-keyword=Floating separation
kn-keyword=Floating separation
en-keyword=Waste solar cell module
kn-keyword=Waste solar cell module
en-keyword=Silicon
kn-keyword=Silicon
en-keyword=Sodium dodecyl sulfate
kn-keyword=Sodium dodecyl sulfate
END

start-ver=1.4
cd-journal=joma
no-vol=35
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=鹿田遺跡13 ー第26次調査ー (医学部動物実験施設改修に伴う発掘調査)
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=YamaguchiYuji
en-aut-sei=Yamaguchi
en-aut-mei=Yuji
kn-aut-name=山口雄治
kn-aut-sei=山口
kn-aut-mei=雄治
aut-affil-num=1
ORCID=

en-aut-name=MinamiKentaro
en-aut-sei=Minami
en-aut-mei=Kentaro
kn-aut-name=南健太郎
kn-aut-sei=南
kn-aut-mei=健太郎
aut-affil-num=2
ORCID=

en-aut-name=IwasakiShiho
en-aut-sei=Iwasaki
en-aut-mei=Shiho
kn-aut-name=岩�ｱ志保
kn-aut-sei=岩�ｱ
kn-aut-mei=志保
aut-affil-num=3
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=渡辺正巳
kn-aut-sei=渡辺
kn-aut-mei=正巳
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=能城修一
kn-aut-sei=能城
kn-aut-mei=修一
aut-affil-num=5
ORCID=

en-aut-name=OkiYoko
en-aut-sei=Oki
en-aut-mei=Yoko
kn-aut-name=沖陽子
kn-aut-sei=沖
kn-aut-mei=陽子
aut-affil-num=6
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=江川達也
kn-aut-sei=江川
kn-aut-mei=達也
aut-affil-num=7
ORCID=

affil-num=1
en-affil= Archaeological Research Center, Okayama University
kn-affil=岡山大学埋蔵文化財調査研究センター

affil-num=2
en-affil=Archaeological Research Center, Okayama University
kn-affil=岡山大学埋蔵文化財調査研究センター

affil-num=3
en-affil=Archaeological Research Center, Okayama University
kn-affil=岡山大学埋蔵文化財調査研究センター

affil-num=4
en-affil=
kn-affil=

affil-num=5
en-affil=
kn-affil=明治大学

affil-num=6
en-affil=
kn-affil=岡山大学

affil-num=7
en-affil=
kn-affil=笠岡市教育委員会
END

start-ver=1.4
cd-journal=joma
no-vol=2017
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190329
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Bulletin of Archaeological Research Center Okayama University 2017
kn-title=岡山大学埋蔵文化財調査研究センター紀要2017
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=NozakiTakahiro
en-aut-sei=Nozaki
en-aut-mei=Takahiro
kn-aut-name=野崎貴博
kn-aut-sei=野崎
kn-aut-mei=貴博
aut-affil-num=1
ORCID=

en-aut-name=MinamiKentaro
en-aut-sei=Minami
en-aut-mei=Kentaro
kn-aut-name=南健太郎
kn-aut-sei=南
kn-aut-mei=健太郎
aut-affil-num=2
ORCID=

en-aut-name=YamamotoEtsuyo
en-aut-sei=Yamamoto
en-aut-mei=Etsuyo
kn-aut-name=山本悦世
kn-aut-sei=山本
kn-aut-mei=悦世
aut-affil-num=3
ORCID=

en-aut-name=SuzukiShigeyuki
en-aut-sei=Suzuki
en-aut-mei=Shigeyuki
kn-aut-name=鈴木茂之
kn-aut-sei=鈴木
kn-aut-mei=茂之
aut-affil-num=4
ORCID=

en-aut-name=YamaguchiYuji
en-aut-sei=Yamaguchi
en-aut-mei=Yuji
kn-aut-name=山口雄治
kn-aut-sei=山口
kn-aut-mei=雄治
aut-affil-num=5
ORCID=

en-aut-name=IwasakiShiho
en-aut-sei=Iwasaki
en-aut-mei=Shiho
kn-aut-name=岩�ｱ志保
kn-aut-sei=岩�ｱ
kn-aut-mei=志保
aut-affil-num=6
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=古環境センター
kn-aut-sei=古環境センター
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=吉田生物研究所
kn-aut-sei=吉田生物研究所
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil= Archaeological Research Center, Okayama University
kn-affil=岡山大学埋蔵文化財調査研究センター

affil-num=2
en-affil= Archaeological Research Center, Okayama University
kn-affil=岡山大学埋蔵文化財調査研究センター

affil-num=3
en-affil= Archaeological Research Center, Okayama University
kn-affil=岡山大学埋蔵文化財調査研究センター

affil-num=4
en-affil= Archaeological Research Center, Okayama University
kn-affil=岡山大学

affil-num=5
en-affil= Archaeological Research Center, Okayama University
kn-affil=岡山大学埋蔵文化財調査研究センター

affil-num=6
en-affil= Archaeological Research Center, Okayama University
kn-affil=岡山大学埋蔵文化財調査研究センター

affil-num=7
en-affil=
kn-affil=

affil-num=8
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=58
cd-vols=
no-issue=5
article-no=
start-page=765
end-page=765
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190301
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Crowned Dens Syndrome Associated with Hyperuricemia
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=SugiharaYuusaku
en-aut-sei=Sugihara
en-aut-mei=Yuusaku
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OgawaHiroko
en-aut-sei=Ogawa
en-aut-mei=Hiroko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=crowned dense syndrome
kn-keyword=crowned dense syndrome
en-keyword=hyperuricemia
kn-keyword=hyperuricemia
END

start-ver=1.4
cd-journal=joma
no-vol=16
cd-vols=
no-issue=19
article-no=
start-page= 3540
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190922
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Influence of Occupational Stress and Coping Style on Periodontitis Among Japanese Workers: A Cross-Sectional Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The aim of this cross-sectional study was to evaluate the association between the influence of occupational stress and coping style on periodontitis among Japanese workers. The study sample included 738 workers (age range: 19-65 years) at a manufacturing company in Kagawa Prefecture, Japan. To analyze occupational stress and coping style, all participants answered a self-report questionnaire composed of items on their work environment and oral health behavior. Oral examinations were performed by calibrated dentists. Among all workers, 492 (66.7%) workers were diagnosed with periodontitis, and 50 (6.8%) were diagnosed with a high stress-low coping condition. Significant differences (p < 0.05) were observed between the periodontitis and non-periodontitis groups in terms of age, gender, body mass index, smoking status, daily alcohol drinking, monthly overtime work, worker type, and stress-coping style. Logistic regression analysis showed that a high stress-low coping condition was associated with an increased risk of periodontitis (odds ratio: 2.79, 95% confidence interval: 1.05-7.43, p = 0.039). These findings suggest that a high stress-low coping condition is associated with periodontitis among the 19-65 years of age group of Japanese workers.
en-copyright=
kn-copyright=

en-aut-name=Md Monirul Islam
en-aut-sei=Md Monirul Islam
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=EkuniDaisuke
en-aut-sei=Ekuni
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YonedaToshiki
en-aut-sei=Yoneda
en-aut-mei=Toshiki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=YokoiAya
en-aut-sei=Yokoi
en-aut-mei=Aya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=MoritaManabu
en-aut-sei=Morita
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

affil-num=1
en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=2
en-affil=Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=3
en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=4
en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=

affil-num=5
en-affil=Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=
en-keyword=Japanese workers
kn-keyword=Japanese workers
en-keyword=coping
kn-keyword=coping
en-keyword=occupational stress
kn-keyword=occupational stress
en-keyword=periodontitis
kn-keyword=periodontitis
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=１８トリソミー症例検出を目的とした小脳径の基準値作成と臨床応用
kn-title=Creation of a cerebellar diameter reference standard and its clinical application to the detection of cerebellar hypoplasia unique to trisomy 18
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HayataKei
en-aut-sei=Hayata
en-aut-mei=Kei
kn-aut-name=早田桂
kn-aut-sei=早田
kn-aut-mei=桂
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学研究科
END

start-ver=1.4
cd-journal=joma
no-vol=
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20191227
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=2型糖尿病患者における血糖値・胃食道逆流症状とうつ状態の関連について
kn-title=Clinical Relevance of Blood Glicose and Gastroesophageal Reflux Symptoms to Depressive Status in Patients with Type 2 Diabetes Mellitus
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HondaHiroyuki
en-aut-sei=Honda
en-aut-mei=Hiroyuki
kn-aut-name=本多寛之
kn-aut-sei=本多
kn-aut-mei=寛之
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=岡山大学大学院医歯薬学総合研究科
END