| ID | 16632 |
| Eprint ID | 16632
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| FullText URL | |
| Title Alternative | Studies of anticancer agent-monoclonal antibody conjugates and their biological activites Part Ⅱ. Production of anti-HLA monoclonal antiboby-ara-C and -MTX conjugates and their biological activities
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| Author |
Manabe, Yuichi
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| Abstract | The anticancer agents 1-β-D-arabinofuranosylcytosine (ara-C) and methotrexate (MTX) were linked covalently to murine monoclonal IgG(1) antibody (H-1) with the use of dextran T-40. H-1 alone did not inhibit cell growth. The ara-C-(H-1) conjugate showed weaker cytotoxicity to an HLA-lacking cell line than ara-C, while ara-C-(H-1) and ara-C showed the same cytotoxicity to HLA-bearing cells. The MTX-(H-1) canjugste showed stronger cytotoxicity to HLA-bearing cells than MTX, while MTX-(H-1) and MTX showed the same cytotoxicity to cells lacking HLA. These results indicate that ara-C-(H-1) and MTX-(H-1) exert antibody-targeting cytotoxicity in vitro.
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| Keywords | 抗HLAモノクロナール抗体
methotrexate (MTX)
cytosine arabinoside (ara-C)
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| Published Date | 1984-12-30
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume96
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| Issue | issue11-12
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 1195
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| End Page | 1203
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/96/11-12/96_11-12_1195/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
|
