| ID | 40769 |
| FullText URL | |
| Title Alternative | Effect of prostaglandin E(1) and prostaglandin F(2α) on bone formation of cultured chick embryonic bone with special reference to the alkaline phosphatase activity
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| Author |
Ueda, Shigeki
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| Abstract | The effects of prostaglandin E(1) (PGE(1)) and prostaglandin F(2α) (PGF(2α)) on bone formation were investigated with femur and tibia from 10-day chick embryo. When the bones were cultured in serum free medium, PGE(1) (10nM) caused a significant increase of bone alkaline phosphatase activity and a slight increase in bone protein content, whereas PGF(2α) (100nM) significantly decreased the enzyme activity. On the other hand, in a medium containing 20% serum, PGE1 did not affect the enzyme activity at 10nM, but slightly increased the activity at 1nM. No effect of PGE(1) on bone calcium content was observed in a concentration ranging from 0.1nM to 100nM. Thus, PGE1 was likely to stimulate bone formation at 10nM, whereas PGF(2α) supressed formation at 100nM.
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| Keywords | 組織培養
プロスタグランディン
骨形成
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| Published Date | 1989-08-31
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume101
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| Issue | issue7-8
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 763
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| End Page | 770
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/101/7-8/101_7-8_763/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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