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JaLCDOI 10.18926/AMO/48562
FullText URL 66_3_231.pdf
Author Takahashi, Kingo| Hayashi, Masamichi| Fujii, Toshihiro| Kawamura, Kenji| Ozaki, Toshifumi|
Abstract The objective of early rehabilitation after anterior cruciate ligament (ACL) reconstruction is to increase the muscle strength of the lower extremities. Closed kinetic chain (CKC) exercise induces co-contraction of the agonist and antagonist muscles. The purpose of this study was to compare the postoperative muscle strength/mass of subjects who performed our new CKC exercise (new rehabilitation group:group N) from week 4, and subjects who received traditional rehabilitation alone (traditional rehabilitation group:group T). The subjects stood on the device and maintained balance. Then, low-frequency stimulation waves were applied to 2 points each in the anterior and posterior region of the injured thigh 3 times a week for 3 months. Measurement of muscle strength was performed 4 times (before the start, and then once a month). Muscle mass was evaluated in CT images of the extensor and flexor muscles of 10 knees (10 subjects) in each group. The injured legs of group N showed significant improvement after one month compared to group T. The cross-sectional area of the extensor muscles of the injured legs tended to a show a greater increase at 3 months in group N. This rehabilitation method makes it possible to contract fast-twitch muscles, which may be a useful for improving extensor muscle strength after ACL reconstruction.
Keywords anterior cruciate ligament reconstruction closed kinetic chain electrical muscle stimulation standing-shaking-board exercise
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2012-06
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 231
End Page 237
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729103
Web of Science KeyUT 000305669700006
JaLCDOI 10.18926/AMO/48561
FullText URL 66_3_221.pdf
Author Takahata, Yoko| Wang, Da-Hong| Anai, Takanobu| Ogino, Keiki|
Abstract This study aimed to elucidate the relationship of prenatal and/or postnatal factors, including acquired factors, with the calcaneus stiffness index as measured by quantitative ultrasound (QUS-SI) in adolescents. We recruited 1,143 adolescents with a mean age of 14.8±1.8 years (501 boys and 642 girls). The subjectsʼ calcaneus QUS-SI was measured using an ultrasound bone densitometer. We also measured the subjectsʼ height, weight, and grip strength. Data on prenatal and postnatal factors were obtained from maternal and child health handbooks. A self-reporting questionnaire was used to obtain information on subjectsʼ secondary sexual characteristics and lifestyle factors. We found that maternal weight gain during pregnancy was independently associated with calcaneus QUS-SI in girls, and that grip strength was also significantly associated with calcaneus QUS-SI in both sexes. The present findings suggest that excessive restriction of maternal weight gain would have a negative effect on the calcaneus QUS-SI of girls, and that exercise and strength-building activities are likely to result in a higher calcaneus QUS-SI in both sexes of adolescents.
Keywords adolescents calcaneus QUS-SI prenatal and/or postnatal status stiffness index ultrasound bone densitometer
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2012-06
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 221
End Page 229
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729102
Web of Science KeyUT 000305669700005
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/48455
JaLCDOI 10.18926/AMO/48560
FullText URL 66_3_213.pdf
Author Kataoka, Masaki| Kunisada, Toshiyuki| Tanaka, Masato| Takeda, Ken| Itani, Satoru| Sugimoto, Yoshihisa| Misawa, Haruo| Senda, Masuo| Nakahara, Shinnosuke| Ozaki, Toshifumi|
Abstract There are a variety of treatment options for patients with spinal metastasis, and predicting prognosis is essential for selecting the proper treatment. The purpose of the present study was to identify the significant prognostic factors for the survival of patients with spinal metastasis. We retrospectively reviewed 143 patients with spinal metastasis. The median age was 61 years. Eleven factors reported previously were analyzed using the Cox proportional hazards model:gender, age, performance status, neurological deficits, pain, type of primary tumor, metastasis to major organs, previous chemotherapy, disease-free interval before spinal metastasis, multiple spinal metastases, and extra-spinal bone metastasis. The average survival of study patients after the first visit to our clinic was 22 months. Multivariate survival analysis demonstrated that type of primary tumor (hazard ratio [HR]=6.80, p<0.001), metastasis to major organs (HR=2.01, p=0.005), disease-free interval before spinal metastasis (HR=1.77, p=0.028), and extra-spinal bone metastasis (HR=1.75, p=0.017) were significant prognostic factors. Type of primary tumor was the most powerful prognostic factor. Other prognostic factors may differ among the types of primary tumor and may also be closely associated with primary disease activity. Further analysis of factors predicting prognosis should be conducted with respect to each type of primary tumor to help accurately predict prognosis.
Keywords spine metastasis survival prognostic factor cancer
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2012-06
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 213
End Page 219
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729101
Web of Science KeyUT 000305669700004
JaLCDOI 10.18926/AMO/48559
FullText URL 66_3_203.pdf
Author Ohno, Seiichiro| Harimoto, Takashi| Hirosue, Miyuki| Miyai, Masahiro| Hattori, Kengo| Kuroda, Masahiro| Kanazawa, Susumu| Inamura, Keiji| Kato, Hirokazu|
Abstract Magnetic resonance imaging (MRI) visualization of metallic stent lumens is possible if the stent structure counteracts eddy currents in the lumen induced by the radio frequency magnetic field, B1. To examine the effectiveness of various stent designs in counteracting eddy currents, we anchored eight copper stent models and 2 commercially available nickel-titanium alloy (Nitinol) stents in a gel phantom, perpendicular or parallel to the direction of B1. A mesh stent lumen showed hypointensity irrespective of its alignment relative to B1. A solenoid stent lumen showed hypointensity with the stent axis parallel to B1, but it had the same signal intensity as outside the lumen when perpendicular to B1. A Moebius stent lumen showed no signal reduction, irrespective of alignment relative to B1. Lumens of the commercially available stents showed hypointensity regardless of alignment relative to B1. Computer simulation revealed that the signal intensities of the stents corresponded to magnetic flux densities of B1 in the stents, which are modified by the structure of the stent. While in vivo MRI viewing of a Moebius stent lumen is likely possible regardless of axis alignment, inherent structural weakness may be problematic. As a more practical choice, the solenoid stent is easier to manufacture and generates no hypointensive signal when the axis is parallel to B0.
Keywords MRI visualization of stent lumen solenoid pattern Moebius pattern direction of B1
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2012-06
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 203
End Page 211
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729100
Web of Science KeyUT 000305669700003
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/48542
JaLCDOI 10.18926/AMO/48558
FullText URL 66_3_191.pdf
Author Kishimoto, Fumiko| Naito, Tomoko| Hasebe, Satoshi| Ohtsuki, Hiroshi|
Abstract The utility value was compared among 3 surgical interventions, and the validity of the time trade-off (TTO) method was evaluated by analyzing the correlations of the utility value with the results of the Visual Function Questionnaire-14 (VF-14) and other variables. The subjects were 127 patients aged 40-85 years who were surgically treated between January 2008 and March 2010, including 26 patients with glaucoma, 50 with cataracts, and 51 with comitant strabismus. The scores on VF-14 and utility values determined using TTO were calculated retrospectively. The mean value (SD) of the utility gain was 0.096 (0.105) for glaucoma, 0.101 (0.105) for comitant strabismus, and 0.167 (0.237) for unilateral and 0.245 (0.167) for bilateral cataracts, indicating significant postoperative improvements in the utility value. A significant correlation was observed between the utility value and the postoperative VF-14 scores of the bilateral cataracts, and the postoperative visual acuity of the better eye of the unilateral cataract. The mean value of the quality-adjusted life years was 2.181 for bilateral and 1.424 for unilateral cataracts, 1.132 for strabismus, and 0.870 for glaucoma with an annual discount rate of 3%. The gain of utility value was highest in bilateral cataracts, and lowest in glaucoma, and thus the TTO analysis was considered to be highly valid for cataract surgery.
Keywords surgical intervention VF-14 utility analysis time trade-off quality-adjusted life years
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2012-06
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 191
End Page 201
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729099
Web of Science KeyUT 000305669700002
JaLCDOI 10.18926/AMO/48557
FullText URL 66_3_183.pdf
Author Tanabe, Kenji| Takei, Kohji|
Abstract Charcot-Marie-Tooth disease (CMT) is an inherited neuronal disorder, and is induced by mutations of various genes associated with intracellular membrane traffic and cytoskeleton. A large GTPase, dynamin, which is known as a fission protein for endocytic vesicles, was identified as a gene responsible for dominant-intermediate CMT type 2B (DI-CMT2B). Of these mutants, the PH domain, which is required for interaction with phosphoinositides, was mutated in several families. Interestingly, the expression of a deletion mutant, 551Δ3, did not impair endocytosis, but induced abnormal accumulation of microtubules. Recent evidence has shown that dynamin 2 regulates the dynamic instability of microtubules, and 551Δ3 lacks this function. We propose a model for the regulation of the dynamic instability of microtubules by dynamin 2 and discuss the relationship between dynamin 2 and CMT.
Keywords neuropathy Charcot-Marie-Tooth disease membrane traffic dynamin microtubules
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2012-06
Volume volume66
Issue issue3
Publisher Okayama University Medical School
Start Page 183
End Page 190
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22729098
Web of Science KeyUT 000305669700001
Author Kida, Katsuhiro|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Mohamed Mahmoud Ahmed, Ahmed|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Kimoto, Takafumi|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Utsumi, Shinya|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Kiplimo, Robert|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Saito, Seiji|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Jin, Yong|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Takahashi, Noriko|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Ma, Shaobo|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
FullText URL K0004501.pdf K004501_honbun.pdf
Author Zhang, Kai|
Published Date 2012-03-23
Content Type Thesis or Dissertation
Grant Number 甲第4501号
Granted Date 2012-03-23
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language Japanese English
Author Jin, Yu|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Mori, Kyoko|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation
Author Harada, Sosuke|
Published Date 2012-03-23
Publication Title
Content Type Thesis or Dissertation