result 18545 件
| Author | Nishimiya, Yusuke| Konuma, Toshimitsu| Tasaka, Ken| Sendo, Toshiaki| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nishii, Nobuhiro| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kataoka, Yuko| Fukushima, Kunihiro| Sugaya, Akiko| Nishizaki, Kazunori| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Kimura, Yuji| Iwakawa, Kazuhide| Nishie, Manabu| Inagaki, Masaru| Iwagaki, Hiromi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Tanabe, Shunsuke| Shirakawa, Yasuhiro| Maeda, Naoaki| Ohara, Toshiaki| Noma, Kazuhiro| Sakurama, Kazufumi| Yanai, Hiroyuki| Yamatsuji, Tomoki| Naomoto, Yoshio| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Ma, Shaobo| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nakao, Miyuki| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Yagi, Takahito| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Doihara, Hiroyoshi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Hayashi, Keiichiro| Ohmori, Iori| Matsui, Hideki| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Wang, Feifei| Yasuhara, Takao| Kameda, Masahiro| Date, Isao| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Sasaki, Tsuyoshi| Tazawa, Hiroshi| Hasei, Jo| Kunisada, Toshiyuki| Yoshida, Aki| Hashimoto, Yuuri| Yano, Shuya| Yoshida, Ryosuke| Uno, Futoshi| Kagawa, Shunsuke| Morimoto, Yuki| Urata, Yasuo| Fujiwara, Toshiyoshi| Ozaki, Toshifumi| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Fujimura, Atsushi| Tomizawa, Kazuhito| Matsui, Hideki| |
|---|---|
| Published Date | 2012-08-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume124 |
| Issue | issue2 |
| Content Type | Journal Article |
| Author | Nagai, Yusuke| |
|---|---|
| Published Date | 2012-02 |
| Publication Title | Biomaterials |
| Volume | volume33 |
| Issue | issue4 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/48569 |
|---|---|
| FullText URL | 66_3_285.pdf |
| Author | Mizobuchi, Satoshi| Matsuoka, Yoshikazu| Obata, Norihiko| Kaku, Ryuji| Itano, Yoshitaro| Tomotsuka, Naoto| Taniguchi, Arata| Nishie, Hiroyuki| Kanzaki, Hirotaka| Ouchida, Mamoru| Morita, Kiyoshi| |
| Abstract | Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required. |
| Keywords | beta-blocker landiolol formalin pain behavior c-fos |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-06 |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 289 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729110 |
| Web of Science KeyUT | 000305669700013 |
| JaLCDOI | 10.18926/AMO/48567 |
|---|---|
| FullText URL | 66_3_271.pdf |
| Author | Lee, Shin-Wha| Kim, Yong-Man| Kim, Moon-Bo| Kim, Dae-Yeon| Kim, Jong-Hyeok| Nam, Joo-Hyun| Kim, Young-Tak| |
| Abstract | The choice of chemotherapeutic drugs to treat patients with epithelial ovarian cancer has not depended on individual patient characteristics. We have investigated the correlation between in vitro chemosensitivity, as determined by the histoculture drug response assay (HDRA), and clinical responses in epithelial ovarian cancer. Fresh tissue samples were obtained from 79 patients with epithelial ovarian cancer. The sensitivity of these samples to 11 chemotherapeutic agents was tested using the HDRA method according to established methods, and we analyzed the results retrospectively. HDRA showed that they were more chemosensitive to carboplatin, topotecan and belotecan, with inhibition rates of 49.2%, 44.7%, and 39.7%, respectively, than to cisplatin, the traditional drug of choice in epithelial ovarian cancer. Among the 37 patients with FIGO stage Ⅲ/Ⅳ serous adenocarcinoma who were receiving carboplatin combined with paclitaxel, those with carboplatin-sensitive samples on HDRA had a significantly longer median disease-free interval than patients with carboplatin- resistant samples (23.2 vs. 13.8 months, p＜0.05), but median overall survival did not differ significantly (60.4 vs. 37.3 months, p＝0.621). In conclusion, this study indicates that HDRA could provide useful information for designing individual treatment strategies in patients with epithelial ovarian cancer. |
| Keywords | chemosensitivity carboplatin HDRA (histoculture drug response assay) epithelial ovarian cancer |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-06 |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 271 |
| End Page | 277 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729108 |
| Web of Science KeyUT | 000305669700011 |
| JaLCDOI | 10.18926/AMO/48566 |
|---|---|
| FullText URL | 66_3_263.pdf |
| Author | Sasaki, Takanori| Kuroda, Masahiro| Katashima, Kazunori| Ashida, Masakazu| Matsuzaki, Hidenobu| Asaumi, Junichi| Murakami, Jun| Ohno, Seiichiro| Kato, Hirokazu| Kanazawa, Susumu| |
| Abstract | The roles of cell density, extracellular space, intracellular factors, and apoptosis induced by the molecularly targeted drug rituximab on the apparent diffusion coefficient (ADC) values were investigated using bio-phantoms. In these bio-phantoms, Ramos cells (a human Burkittｾs lymphoma cell line) were encapsulated in gellan gum. The ADC values decreased linearly with the increase in cell density, and declined steeply when the extracellular space became less than 4 μm. The analysis of ADC values after destruction of the cellular membrane by sonication indicated that approximately 65% of the ADC values of normal cells originate from the cell structures made of membranes and that the remaining 35% originate from intracellular components. Microparticles, defined as particles smaller than the normal cells, increased in number after rituximab treatments, migrated to the extracellular space and significantly decreased the ADC values of bio-phantoms during apoptosis. An in vitro study using bio-phantoms was conducted to quantitatively clarify the roles of cellular factors and of extracellular space in determining the ADC values yielded by tumor cells and the mechanism by which apoptosis changes those values. |
| Keywords | apparent diffusion coefficient value cell density extracellular space bio-phantom |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-06 |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 263 |
| End Page | 270 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729107 |
| Web of Science KeyUT | 000305669700010 |
| JaLCDOI | 10.18926/AMO/48565 |
|---|---|
| FullText URL | 66_3_253.pdf |
| Author | Zhang, Kai| Yamamoto, Yumiko| Suzuki, Tomonori| Yokota, Kenji| Ma, Shaobo| Nengah Dwi Fatmawati, Ni| Oguma, Keiji| |
| Abstract | Cultured Clostridium botulinum strains produce progenitor toxins designated as 12S, 16S, and 19S toxins. The 12S toxin consists of a neurotoxin (NTX, 7S) and a non-toxic non-hemagglutinin (NTNH). The 16S and 19S toxins are formed by conjugation of the 12S toxin with hemagglutinin (HA), and the 19S toxin is a dimer of the 16S toxin. Type A cultures produce all 3 of these progenitor toxins, while type E produces only the 12S toxin. The 7S toxin is cleaved into heavy (H) and light (L) chains by a protease(s) in some strains, and the H chain has 2 domains, the N-terminus (Hn) and C-terminus (Hc). It has been reported that type A toxins bind to the intestinal cells or cultured cells via either HA or Hc. In this study, we investigated the binding of type A and E toxins to Caco-2 cells using Western blot analysis. Both the type E 7S and 12S toxins bound to the cells, with the 7S toxin binding more strongly, whereas, in the type A strain, only the 16S/19S toxins showed obvious binding. Pre-incubation of the type E 7S toxin with IgG against recombinant type E Hc significantly inhibited the 7S toxin binding, indicating that Hc might be a main binding domain of the type E toxin. |
| Keywords | Clostridum botulinum neurotoxins Caco-2 binding Hc |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-06 |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 253 |
| End Page | 261 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729106 |
| Web of Science KeyUT | 000305669700009 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/48451 |
| JaLCDOI | 10.18926/AMO/48564 |
|---|---|
| FullText URL | 66_3_245.pdf |
| Author | Okada, Toshiaki| Takigawa, Nagio| Kishino, Daizo| Katayama, Hideki| Kuyama, Shouichi| Sato, Ken| Mimoto, Junko| Ueoka, Hiroshi| Tanimoto, Mitsune| Kiura, Katsuyuki| |
| Abstract | Cisplatin is used to treat lung cancer;however, it is also a known carcinogen. Cyclooxygenase-2 (COX-2) inhibitors have been shown to prevent carcinogen-induced experimental tumors. We investigated the effect of a COX-2 inhibitor, celecoxib, on cisplatin-induced lung tumors. One hundred twenty 4-week-old A/J mice were divided into 6 groups:group 1, no treatment;group 2, low-dose celecoxib (150mg/kg);group 3, high-dose celecoxib (1,500mg/kg);group 4, cisplatin alone;group 5, cisplatin plus low-dose celecoxib;and group 6, cisplatin plus high-dose celecoxib. Mice in groups 4-6 were administered cisplatin (1.62mg/kg, i.p.) once a week for 10 weeks between 7 and 16 weeks of age. All mice were sacrificed at week 30. Tumor incidence was 15.8% in group 1, 25% in group 2, 26.3% in group 3, 60% in group 4, 50% in group 5, and 50% in group 6. Tumor multiplicity was 0.2, 0.3, 0.3, 1.3, 1.0, and 0.6 in groups 1-6, respectively. Tumor multiplicity in the cisplatin-treated mice was reduced by celecoxib treatment in a dose-dependent manner (p＜0.05, group 4 vs. group 6). Celecoxib significantly reduced COX-2 expression in cisplatin-induced tumors (p＜0.01, group 4 vs. group 6). |
| Keywords | cisplatin non-small cell lung cancer celecoxib cyclooxygenase-2 chemoprevention |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-06 |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 245 |
| End Page | 251 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729105 |
| Web of Science KeyUT | 000305669700008 |
| JaLCDOI | 10.18926/AMO/48563 |
|---|---|
| FullText URL | 66_3_239.pdf |
| Author | Sawa, Kiminari| Mizushima, Takaaki| Matsushita, Koki| Shirahige, Akinori| Ochi, Koji| Koide, Norio| |
| Abstract | Plain abdominal radiography is a very basic examination and plays an important role in primary care. The objectives of this study were to clarify colon distributions on plain abdominal radiographs. Forty-three healthy volunteers underwent gastric fluoroscopy, and 2 hours later, plain abdominal radiography in the supine position. A region of interest (ROI) was defined uniformly on each X-ray image to divide the image into 600 zones. The area corresponding to the large bowel within the ROI was divided into 4 segments (ascending colon, transverse colon, descending colon, and sigmoid colon＋rectum). The percentage of barium in each segment relative to the total volume of barium used was calculated to evaluate the percent ROI occupancy. The large bowel covered 76.7% of the entire ROI, with the percent duplication being 55%. The duplicated area corresponded to the transverse colon region. When the method proposed by Arhan et al. was used, the percentage of the colon actually present in each segment relative to that determined theoretically was 99.6% for the right colon segment, 92.2% for the left colon segment, and 92.2% for the sigmoid/rectal segment. However, in cases in which the transverse colon descended partially from the fifth lumbar vertebra, the percentage occupied by the sigmoid colon＋rectum decreased to 57.2%. We applied a new large bowel segmentation method especially for patients with ptosis, by devising a line joining the lateral side of the right lesser pelvis and the lower ends of both sacroiliac joints. |
| Keywords | large bowel segmentation plain abdominal radiograph classification method primary care |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-06 |
| Volume | volume66 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 239 |
| End Page | 244 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22729104 |
| Web of Science KeyUT | 000305669700007 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/48881 |
