result 24577 件
| JaLCDOI | 10.18926/AMO/52788 |
|---|---|
| FullText URL | 68_4_219.pdf |
| Author | Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi| |
| Abstract | Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r＝0.48, p＝0.001) or cortex (r＝0.64, p＜0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r＝0.34, p＝0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r＝0.44, p＝0.01) or medulla (r＝0.63, p＝0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2. |
| Keywords | chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2 |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 219 |
| End Page | 233 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145408 |
| Web of Science KeyUT | 000340687500004 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52824 |
| JaLCDOI | 10.18926/AMO/52787 |
|---|---|
| FullText URL | 68_4_207.pdf |
| Author | Yu, Liling| Kato, Yutaka| Shishido, Keisuke| Doi, Hideko| Jin, Haeng mi| Wang, Jin gang| Ikezawa, Junko| Awaya, Tsuyoshi| |
| Abstract | This study examines the attitudes of young Japanese, Chinese, and South Koreans toward birth and child-rearing. The survey targeted four-year university students (n＝1,668) who responded to an anonymous survey using self-report questionnaires between December 2012 and April 2013. The collection rates were 72.5%, 94.7%, and 96.5% for the Japanese, Chinese, and South Korean students, respectively. Correlations among the respondentsʼ attributes, medical and scientific literacy levels, and views of preferred qualities of children were analyzed using chi-square test, supplemented by residual analysis (significance level set at p＜0.05). Participants were asked whether they were willing to use the following methods for obtaining preferred qualities in their children:(1) choosing a spouse (43.2%, 72.6%, and 85.1% of the Japanese, Chinese, and South Koreans, respectively, agreed);(2) using a sperm bank (cryobank) (5.8%, 60.1%, and 81.7% of the Japanese, Chines, and South Koreans, respectively, agreed);and (3) using an egg cell bank (ova bank or cryobank) (5.3%, 47.2%, and 70.3% of the Japanese, Chinese, and South Koreans, respectively, agreed). The proportion of affirmative responses (indicating “eugenic inclination”) to these statements was significantly higher among the Chinese and South Korean participants than their Japanese counterparts (p＜0.001). Significant differences were also found in the attitudes of the 3 groups toward methods for obtaining the preferred qualities for their children:prenatal diagnosis, pre-implantation diagnosis, the environment during pregnancy, and child-rearing. |
| Keywords | prenatal diagnosis pre-implantation diagnosis delivery and child-rearing eugenics healthy birth and child-rearing |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 207 |
| End Page | 218 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145407 |
| Web of Science KeyUT | 000340687500003 |
| Related Url | http://ousar.lib.okayama-u.ac.jp/metadata/52823 |
| JaLCDOI | 10.18926/AMO/52786 |
|---|---|
| FullText URL | 68_4_201.pdf |
| Author | Endo, Hirosuke| Akazawa, Hirofumi| Mitani, Shigeru| Okada, Yoshiki| Yamane, Kentaro| Ozaki, Toshifumi| |
| Abstract | We reviewed the treatment outcome in 14 hips of 7 patients who were diagnosed as having bilateral developmental dislocation of the hip (DDH) after walking age and could be followed up until they were at least 14 years of age. Based on the results of two-directional arthrography of the hip, closed reduction was performed in 2 hips, and open reduction was performed without osteotomy in 12 hips. The final radiographic evaluations were made according to the Kalamchi and MacEwen classification and Severin classification. The mean age at the initial visit was 1 year and 9 months (range, 1 year and 5 months to 3 years). The outcome was satisfactory for one hip in Group Ⅰ and 2 hips in Group Ⅱ according to the Kalamchi and MacEwen classification, and in 83% of the Severin Class Ⅰ and Ⅱ hips. Arthrography was useful for identifying asymmetry, demonstrating the usefulness of a treatment strategy based on arthrography of the hip. |
| Keywords | developmental dislocation of the hip bilateral case arthrogram open reduction after walking age |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 201 |
| End Page | 206 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145406 |
| Web of Science KeyUT | 000340687500002 |
| JaLCDOI | 10.18926/AMO/52785 |
|---|---|
| FullText URL | 68_4_191.pdf |
| Author | Shien, Kazuhiko| Yamamoto, Hiromasa| Soh, Junichi| Miyoshi, Shinichiro| Toyooka, Shinichi| |
| Abstract | Non-small cell lung cancer (NSCLC) harboring an activating mutation within the epidermal growth factor receptor (EGFR) was defined as a clinically distinct molecular group. These lesions show oncogene addiction to EGFR and dramatic responses to the EGFR tyrosine kinase inhibitors (TKIs). Several large Phase III trials have shown that EGFR-TKIs improved the progression-free survival of patients with EGFR mutant NSCLC compared to conventional chemotherapy. However, the long-term effectiveness of EGFR-TKIs is usually limited because of acquired drug resistance. To overcome this resistance to EGFR-TKIs, it will be essential to identify the specific mechanisms underlying the resistance. Many investigators have attempted to identify the mechanisms using preclinical models and drug-resistant clinical samples. As a result, several mechanisms have been showed to be responsible for the resistance, but not all of the relevant mechanisms have been uncovered. In this review, we provide an overview of mechanisms underlying drug-resistance to EGFR-TKIs, focusing on results obtained with preclinical models, and we present some possible strategies to overcome the EGFR-TKI resistance. |
| Keywords | non-small cell lung cancer EGFR mutation tyrosine-kinase inhibitor drug resistance cancer stem cell |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-08 |
| Volume | volume68 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 191 |
| End Page | 200 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 25145405 |
| Web of Science KeyUT | 000340687500001 |
| Author | Hayakawa, Hiromi| Ichihara, Eiki| Ohashi, Kadoaki| Ninomiya, Takashi| Yasugi, Masayuki| Takata, Saburo| Sakai, Katsuya| Matsumoto, Kunio| Takigawa, Nagio| Tanimoto, Mitsune| Kiura, Katsuyuki| |
|---|---|
| Published Date | 2013-11 |
| Publication Title | Cancer Science |
| Volume | volume104 |
| Issue | issue11 |
| Content Type | Journal Article |
| Author | Kurahashi, Hiroaki| Watanabe, Masami| Sugimoto, Morito| Ariyoshi, Yuichi| Mahmood, Sabina| Araki, Motoo| Ishii, Kazushi| Nasu, Yasutomo| Nagai, Atsushi| Kumon, Hiromi| |
|---|---|
| Published Date | 2013-12 |
| Publication Title | Endocrine Journal |
| Volume | volume60 |
| Issue | issue12 |
| Content Type | Journal Article |
| Author | Hayashi, Tatsuro| Asano, Hiroaki| Toyooka, Shinichi| Tsukuda, Kazunori| Soh, Junichi| Shien, Tadahiko| Taira, Naruto| Maki, Yuho| Tanaka, Norimitsu| Doihara, Hiroyoshi| Nasu, Yasutomo| Huh, Nam-ho| Miyoshi, Shinichiro| |
|---|---|
| Published Date | 2012-05 |
| Publication Title | Journal of Cancer Research and Clinical Oncology |
| Volume | volume138 |
| Issue | issue5 |
| Content Type | Journal Article |
| Author | 脇本 恭子| |
|---|---|
| Published Date | 2014-08-01 |
| Publication Title | Persica |
| Volume | volume41 |
| Content Type | Journal Article |
| Author | 福永 信哲| |
|---|---|
| Published Date | 2014-08-01 |
| Publication Title | Persica |
| Volume | volume41 |
| Content Type | Journal Article |
| Author | Yamaneki, Kanako| |
|---|---|
| Published Date | 2014-08-01 |
| Publication Title | Persica |
| Volume | volume41 |
| Content Type | Journal Article |
| Author | Takahara, Masahiro| Nemoto, Yasuhiro| Oshima, Shigeru| Matsuzawa, Yu| Kanai, Takanori| Okamoto, Ryuichi| Tsuchiya, Kiichiro| Nakamura, Tetsuya| Yamamoto, Kazuhide| Watanabe, Mamoru| |
|---|---|
| Published Date | 2013-12 |
| Publication Title | Immunology Letters |
| Volume | volume156 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Takayama, Hiroki| Miyake, Yasuhiro| Nouso, Kazuhiro| Ikeda, Fusao| Shiraha, Hidenori| Takaki, Akinobu| Kobashi, Haruhiko| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2011-01 |
| Publication Title | Journal of Gastroenterology and Hepatology |
| Volume | volume26 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Higashi, Reiji| Uraoka, Toshio| Kato, Jun| Kuwaki, Kenji| Ishikawa, Shin| Saito, Yutaka| Matsuda, Takahisa| Ikematsu, Hiroaki| Sano, Yasushi| Suzuki, Seiyuu| Murakami, Yoshitaka| Yamamoto, Kazuhide| |
|---|---|
| Published Date | 2010-07 |
| Publication Title | Gastrointestinal Endoscopy |
| Volume | volume72 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Miyai, Takayuki| Aya, Kunihiko| Takaiwa, Masanori| Yan, Kunimasa| Sado, Yoshikazu| Tanaka, Hiroyuki| Morishima, Tsuneo| |
|---|---|
| Published Date | 2014-02 |
| Publication Title | Histology and Histopathology |
| Volume | volume29 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/OER/52738 |
|---|---|
| Title Alternative | J. H. Clapham, An Economic History of Modern Britain, vol.II, Book 3, Free Trade and Steel, 1850-1886 (1st ed., 1932), Outline, Chap. 5, Chap. 6 |
| FullText URL | oer_046_1_123_147.pdf |
| Author | Ichinose, Atsushi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-07-04 |
| Volume | volume46 |
| Issue | issue1 |
| Start Page | 123 |
| End Page | 147 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005457104 |
| JaLCDOI | 10.18926/OER/52737 |
|---|---|
| Title Alternative | Interview on Resistance in Organizational Change (2) |
| FullText URL | oer_046_1_081_122.pdf |
| Author | Matsuda, Yoichi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-07-04 |
| Volume | volume46 |
| Issue | issue1 |
| Start Page | 81 |
| End Page | 122 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005457105 |
| JaLCDOI | 10.18926/OER/52736 |
|---|---|
| Title Alternative | Trend of Japan’s Foreign Direct Investment in China |
| FullText URL | oer_046_1_069_080.pdf |
| Author | Teng, Jian| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-07-04 |
| Volume | volume46 |
| Issue | issue1 |
| Start Page | 69 |
| End Page | 80 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005457106 |
| JaLCDOI | 10.18926/OER/52735 |
|---|---|
| Title Alternative | On the Unemployment and the Labor Market Reforms in Spain after Franco Régime |
| FullText URL | oer_046_1_047_068.pdf |
| Author | Hatakeyama, Akinobu| Shimizu, Koichi| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-07-04 |
| Volume | volume46 |
| Issue | issue1 |
| Start Page | 47 |
| End Page | 68 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005457107 |
| JaLCDOI | 10.18926/OER/52734 |
|---|---|
| Title Alternative | Implementation of the Toyota Production System at a Japan-China Joint-Venture, DQAM, in China |
| FullText URL | oer_046_1_031_046.pdf |
| Author | Han, Liang| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-07-04 |
| Volume | volume46 |
| Issue | issue1 |
| Start Page | 31 |
| End Page | 46 |
| ISSN | 0386-3069 |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005457108 |
| JaLCDOI | 10.18926/OER/52733 |
|---|---|
| Title Alternative | Extension of Professional Skepticism by the Audit Firm |
| FullText URL | oer_046_1_001_030.pdf |
| Author | Yoshida, Chikakuni| |
| Publication Title | 岡山大学経済学会雑誌 |
| Published Date | 2014-07-04 |
| Volume | volume46 |
| Issue | issue1 |
| Start Page | 1 |
| End Page | 30 |
| ISSN | 0386-3069 |
| Related Url | http://www.e.okayama-u.ac.jp/gakkai/ |
| language | Japanese |
| Copyright Holders | Copyright © 2014 岡山大学経済学会 |
| File Version | publisher |
| NAID | 120005457109 |
