result 48225 件
| JaLCDOI | 10.18926/AMO/60368 |
|---|---|
| FullText URL | 74_4_301.pdf |
| Author | Takahashi, Kei| Kitamura, Yoshihisa| Ushio, Soichiro| Sendo, Toshiaki| |
| Abstract | Ketamine has been clinically proven to ameliorate depression, including treatment-resistant depression. The detailed mechanism of action of ketamine in treatment-resistant depression remains unclear. We examined the effects of ketamine on the immobility times of adrenocorticotropic hormone (ACTH)-treated rats during the forced swim test, and we explored the mechanism by which ketamine acts in this model. We investigated the neuroanatomical site of action by microinjecting ketamine into the medial prefrontal cortex of rats. A significant reduction of the rats’ immobility during the forced swim test was observed after the intraperitoneal injection of ketamine in both saline- and ACTH-treated rats. The microinjection of ketamine into the medial prefrontal cortex also decreased immobility during the forced swim test in both saline- and ACTH-treated rats. The immobility-decreasing effect of intraperitoneally injected ketamine was blocked by administering WAY100635, a 5-HT1A receptor antagonist, into the medial prefrontal cortex. These findings contribute to the evidence that ketamine can be useful against treatment-resistant depressive conditions. The immobility-reducing effects of ketamine might be mediated by 5-HT1A receptor activity in the medial prefrontal cortex. |
| Keywords | ketamine adrenocorticotropic hormone forced swim test medial prefrontal cortex 5-HT1A receptor |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 301 |
| End Page | 306 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843761 |
| Web of Science KeyUT | 000562508700005 |
| NAID | 120006880207 |
| JaLCDOI | 10.18926/AMO/60367 |
|---|---|
| FullText URL | 74_4_293.pdf |
| Author | Yoshioka, Takashi| Omae, Kenji| Kawada, Tatsushi| Inoue, Yosuke| Sugimoto, Morito| Oeda, Tadashi| Uehara, Shinya| Araki, Motoo| Fukuhara, Shunichi| |
| Abstract | In this retrospective single-center cohort study, we investigated the impact of preoperative use of an alpha-1 adrenergic receptor (AR) blocker on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) in 193 male patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blockers. The primary outcome was treatment success after single-session SWL. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively. A multivariable analysis showed that preoperative use of an alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio 0.17; 95% confidence intervals, 0.04-0.74). Our findings suggest that the preoperative use of an alpha-1 AR blocker was a negative predictor of treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality. |
| Keywords | urolithiasis extracorporeal shockwave therapy adrenergic alpha-1 receptor antagonists |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 293 |
| End Page | 299 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843760 |
| Web of Science KeyUT | 000562508700004 |
| NAID | 120006880206 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kitamura, Shinji| Takahashi, Kensaku| Sang, Yizhen| Fukushima, Kazuhiko| Tsuji, Kenji| Wada, Jun| |
| Keywords | immunofluorescent image renal pathology artificial intelligence deep learning diabetic nephropathy |
| Published Date | 2020-07-09 |
| Publication Title | Diagnostics |
| Volume | volume10 |
| Issue | issue7 |
| Publisher | MDPI |
| Start Page | 466 |
| ISSN | 2075-4418 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32660112 |
| DOI | 10.3390/diagnostics10070466 |
| Web of Science KeyUT | 000557155500001 |
| Related Url | isVersionOf https://doi.org/10.3390/diagnostics10070466 |
| JaLCDOI | 10.18926/AMO/60365 |
|---|---|
| FullText URL | 74_4_285.pdf |
| Author | Tsukahara, Kohei| Naitou, Hiromichi| Yorifuji, Takashi| Nosaka, Nobuyuki| Yamamoto, Hirotsugu| Osako, Takaaki| Nakao, Atsunori| the JaRPAC Study Group| |
| Abstract | The importance of centralizing treatment services for severely ill children has been well established, but such entralization remains difficult in Japan. We aimed to compare the trauma and illness severity and mortality of children admitted to two common types of ICUs for children. According to the type of management and disposition of the medical provider, we classified ICUs as pediatric ICUs [PICUs] or general ICUs, and analyzed differences in endogenous and exogenous illness settings between them. Overall, 1,333 pediatric patients were included, with 1,143 patients admitted to PICUs and 190 patients to general ICUs. The Pediatric Cerebral Performance Category score (PCPC) at discharge was significantly lower in the PICU group (adjusted OR: 0.45; 95%CI: 0.23-0.88). Death and unfavorable neurological outcomes occurred less often in the PICU group (adjusted OR: 0.29; 95%CI: 0.14-0.60). However, when limited to exogenous illness, PCPC scores (adjusted OR: 0.38; 95%CI: 0.07-1.99) or death/unfavorable outcomes (adjusted OR: 0.72; 95%CI: 0.08-6.34) did not differ between the groups. PCPC deterioration and overall sequelae/death rates were lower in PICUs for children with endogenous illnesses, although the outcomes of exogenous illness were similar between the 2 unit types. Further studies on the necessity of centralization are warranted. |
| Keywords | kids critical care mortality morbidity centralization |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 285 |
| End Page | 291 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843759 |
| Web of Science KeyUT | 000562508700003 |
| NAID | 120006880204 |
| JaLCDOI | 10.18926/AMO/60364 |
|---|---|
| FullText URL | 74_4_275.pdf |
| Author | Muro, Taiko| Nakamura, Shinichiro| Takaki, Akinobu| Onishi, Hideki| Wada, Nozomu| Yasunaka, Tetsuya| Uchida, Daisuke| Oyama, Atsushi| Adachi, Takuya| Shiraha, Hidenori| Okada, Hiroyuki| |
| Abstract | Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment. |
| Keywords | oxidative stress hepatocellular carcinoma recurrence, radiofrequency ablation |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 275 |
| End Page | 283 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843758 |
| Web of Science KeyUT | 000562508700002 |
| NAID | 120006880203 |
| JaLCDOI | 10.18926/AMO/60363 |
|---|---|
| FullText URL | 74_4_265.pdf |
| Author | Inokuchi, Toshihiro| Hiraoka, Sakiko| Yasutomi, Eriko| Oka, Shohei| Yamasaki, Yasushi| Kinugasa, Hideaki| Takahar, Masahiro| Kawano, Seiji| Harada, Keita| Okada, Hiroyuki| Kato, Jun| |
| Abstract | Determining factors that predict a favorable disease course without anti-tumor necrosis factor (TNF) agents would help establish a more cost-effective strategy for Crohn’s disease (CD). A retrospective chart review was performed for CD patients with disease durations > 10 years who had not received anti-TNF agents as first-line therapy. Patients were divided into 2 groups: those who received neither anti-TNF agents nor bowel resection (G1), and those who had received an anti-TNF agent and/or bowel resection (G2). The patient backgrounds, therapies and clinical courses were compared between the groups. A total of 62 CD patients met the inclusion criteria (males: 71%; median duration of follow-up: 19 years). Six patients were included in G1; they were significantly less likely to have upper gastrointestinal lesions than G2 (p=0.007). A multivariate analysis revealed that the significant factors for avoidance of bowel resection without anti-TNF treatment were non-stricturing and non-penetrating behaviors, and absence of upper gastrointestinal lesions at the diagnosis (hazard ratios 0.41 and 0.52; p=0.004 and 0.04, respectively). In consideration of the long treatment course of CD, patients with non-stricturing and non-penetrating behaviors and no upper gastrointestinal lesions should not be treated with anti-TNF agents as first-line therapy. |
| Keywords | Crohn’s disease anti-TNF agent upper gastrointestinal lesion bamboo joint-like appearance |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-08 |
| Volume | volume74 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 265 |
| End Page | 274 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32843757 |
| Web of Science KeyUT | 000562508700001 |
| NAID | 120006880202 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yamashiro, Keisuke| Ideguchi, Hidetaka| Aoyagi, Hiroaki| Yoshihara-Hirata, Chiaki| Hirai, Anna| Suzuki-Kyoshima, Risa| Zhang, Yao| Wake, Hidenori| Nishibori, Masahiro| Yamamoto, Tadashi| Takashiba, Shogo| |
| Keywords | high mobility group box 1 inflammation periodontal regeneration periodontitis osseointegration tooth movement wound healing |
| Published Date | 2020-07-14 |
| Publication Title | Frontiers in Immunology |
| Volume | volume11 |
| Publisher | Frontiers Media |
| Start Page | 1461 |
| ISSN | 1664-3224 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Yamashiro et al. |
| File Version | publisher |
| PubMed ID | 32760399 |
| DOI | 10.3389/fimmu.2020.01461 |
| Web of Science KeyUT | 000556581900001 |
| Related Url | isVersionOf https://doi.org/10.3389/fimmu.2020.01461 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Morikawa, Yuko| Morimoto, Setsuyo| Yoshida, Eri| Naka, Shuhei| Inaba, Hiroaki| Matsumoto-Nakano, Michiyo| |
| Keywords | Streptococcus mutans glutamine transporter biofilm membrane protein glnP |
| Published Date | 2020-08-04 |
| Publication Title | Journal of Oral Microbiology |
| Volume | volume12 |
| Issue | issue1 |
| Publisher | Taylor & Francis |
| Start Page | 1797320 |
| ISSN | 2000-2297 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s). |
| File Version | publisher |
| DOI | 10.1080/20002297.2020.1797320 |
| Web of Science KeyUT | 000555592200001 |
| Related Url | isVersionOf https://doi.org/10.1080/20002297.2020.1797320 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nanki, Yoshiko| Chiyoda, Tatsuyuki| Hirasawa, Akira| Ookubo, Aki| Itoh, Manabu| Ueno, Masaru| Akahane, Tomoko| Kameyama, Kaori| Yamagami, Wataru| Kataoka, Fumio| Aoki, Daisuke| |
| Published Date | 2020-07-28 |
| Publication Title | Scientific Reports |
| Volume | volume10 |
| Issue | issue1 |
| Publisher | Nature |
| Start Page | 12581 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2020 |
| File Version | publisher |
| PubMed ID | 32724113 |
| DOI | 10.1038/s41598-020-69488-9 |
| Web of Science KeyUT | 000556398500004 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-020-69488-9 |
| FullText URL | 48_320.pdf |
|---|---|
| Author | Yumoto, Yasuhiro| Hanafusa, Tadashi| Nagamatsu, Tomohiro| Okada, Shigeru| |
| Keywords | low level radioactive sample (LLRS) low energy β-emitter Imaging Plate experimental incineration system |
| Published Date | 1999-05-15 |
| Publication Title | Radioisotopes |
| Volume | volume48 |
| Issue | issue5 |
| Publisher | 日本アイソトープ協会 |
| Start Page | 320 |
| End Page | 326 |
| ISSN | 00338303 |
| NCID | AN00351589 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| NAID | 10002684844 |
| FullText URL | 46_443.pdf |
|---|---|
| Author | 湯本 泰弘| 花房 直志| 永松 知洋| 岡田 茂| |
| Keywords | low level radioactive sample (LLRS) experimental incineration system for LLRS |
| Published Date | 1997-7-15 |
| Publication Title | Radioisotopes |
| Volume | volume46 |
| Issue | issue7 |
| Publisher | 日本アイソト-プ協会 |
| Start Page | 443 |
| End Page | 449 |
| ISSN | 00338303 |
| NCID | AN00351589 |
| Content Type | Journal Article |
| language | Japanese |
| OAI-PMH Set | 岡山大学 |
| NAID | 10003721742 |
| JaLCDOI | 10.18926/okadaironkou/60356 |
|---|---|
| FullText URL | okadaironkou_20_81_85.df.pdf |
| Author | 上村 敦之| |
| Abstract | 研究ノート |
| Publication Title | 岡大国文論稿 |
| Published Date | 1992-03-31 |
| Issue | issue20 |
| Start Page | 81 |
| End Page | 85 |
| ISSN | 0386-3123 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60355 |
|---|---|
| FullText URL | okadaironkou_20_80_73.pdf |
| Author | 下河部 行輝| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1992-03-31 |
| Issue | issue20 |
| Start Page | 80 |
| End Page | 73 |
| ISSN | 0386-3123 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60354 |
|---|---|
| FullText URL | okadaironkou_20_60_71.pdf |
| Author | 石上 敏| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1992-03-31 |
| Issue | issue20 |
| Start Page | 60 |
| End Page | 71 |
| ISSN | 0386-3123 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60353 |
|---|---|
| FullText URL | okadaironkou_20_48_59.pdf |
| Author | 高瀬 和子| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1992-03-31 |
| Issue | issue20 |
| Start Page | 48 |
| End Page | 59 |
| ISSN | 0386-3123 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60352 |
|---|---|
| FullText URL | okadaironkou_20_38_47.pdf |
| Author | 吉田 俊彦| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1992-03-31 |
| Issue | issue20 |
| Start Page | 38 |
| End Page | 47 |
| ISSN | 0386-3123 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60351 |
|---|---|
| FullText URL | okadaironkou_20_26_37.pdf |
| Author | 赤羽 学| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1992-03-31 |
| Issue | issue20 |
| Start Page | 26 |
| End Page | 37 |
| ISSN | 0386-3123 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60350 |
|---|---|
| FullText URL | okadaironkou_20_17_25.pdf |
| Author | 劉 若芬| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1992-03-31 |
| Issue | issue20 |
| Start Page | 17 |
| End Page | 25 |
| ISSN | 0386-3123 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60349 |
|---|---|
| FullText URL | okadaironkou_20_9_16.pdf |
| Author | 劉 小俊| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1992-03-31 |
| Issue | issue20 |
| Start Page | 9 |
| End Page | 16 |
| ISSN | 0386-3123 |
| language | Japanese |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60348 |
|---|---|
| FullText URL | okadaironkou_20_1_8.pdf |
| Author | 柏谷 嘉弘| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1992-03-31 |
| Issue | issue20 |
| Start Page | 1 |
| End Page | 8 |
| ISSN | 0386-3123 |
| language | Japanese |
| File Version | publisher |
