result 21324 件
| Author | Tominaga, Hisao| Nagahara, Takasi| |
|---|---|
| Published Date | 1970 |
| Publication Title | Mathematical Journal of Okayama University |
| Volume | volumeSpecial Issue |
| Content Type | Others |
| JaLCDOI | 10.18926/48287 |
|---|---|
| FullText URL | hss_033_001_014.pdf |
| Author | Hagiwara, Naoyuki| |
| Publication Title | 岡山大学大学院社会文化科学研究科紀要 |
| Published Date | 2012-03-26 |
| Volume | volume33 |
| Start Page | 1 |
| End Page | 14 |
| ISSN | 1881-1671 |
| language | French |
| Copyright Holders | Copyright © 2012 岡山大学大学院社会文化科学研究科 |
| File Version | publisher |
| NAID | 40019262837 |
| Author | 岡山大学大学院社会文化科学研究科| |
|---|---|
| Published Date | 2012-03-26 |
| Publication Title | 岡山大学大学院社会文化科学研究科紀要 |
| Volume | volume33 |
| Content Type | Others |
| Author | Ghosh, Souvik| Alam, Mohammed Mahbub| Ahmed, Muzahed Uddin| Talukdar, Rafiqul Islam| Paul, Shyamal Kumar| Kobayashi, Nobumichi| |
|---|---|
| Published Date | 2010-09 |
| Publication Title | Journal of General Virology |
| Volume | volume91 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Khan, Shahbaz Manzoor| Debnath, Chanchal| Pramanik, Amiya Kumar| Xiao, Lihua| Nozaki, Tomoyoshi| Ganguly, Sandipan| |
|---|---|
| Published Date | 2010-07-15 |
| Publication Title | Veterinary Parasitology |
| Volume | volume171 |
| Issue | issue1-2 |
| Content Type | Journal Article |
| Author | Ghosh, Souvik| Gatheru, Zipporah| Nyangao, James| Adachi, Noriaki| Urushibara, Noriko| Kobayashi, Nobumichi| |
|---|---|
| Published Date | 2011-01 |
| Publication Title | Infection, Genetics and Evolution |
| Volume | volume11 |
| Issue | issue1 |
| Content Type | Journal Article |
| Author | Nair, Gopinath Balakrish| Ramamurthy, Thandavarayan| Bhattacharya, Mihir Kumar| Krishnan, Triveni| Ganguly, Sandipan| Saha, Dhira Rani| Rajendran, Krishnan| Manna, Byomkesh| Ghosh, Mrinmoy| Okamoto, Keinosuke| Takeda, Yoshifumi| |
|---|---|
| Published Date | 2010-06-05 |
| Publication Title | Gut Pathogens |
| Volume | volume2 |
| Content Type | Journal Article |
| Author | Mukherjee, Avik K| Das, Kaushik| Bhattacharya, Mihir K| Nozaki, Tomoyoshi| Ganguly, Sandipan| |
|---|---|
| Published Date | 2010-10-06 |
| Publication Title | Gut Pathogens |
| Volume | volume2 |
| Content Type | Journal Article |
| Author | Ghosh, S| Kobayashi, N| Nagashima, S| Chawla-Sarkar, M| Krishnan, T| Ganesh, B| Naik, TN| |
|---|---|
| Published Date | 2009-11-21 |
| Publication Title | Archives of Virology |
| Volume | volume155 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/48268 |
|---|---|
| FullText URL | 66_2_177.pdf.pdf |
| Author | Utsumi, Masashi| Matsuda, Hiroaki| Sadamori, Hiroshi| Shinoura, Susumu| Umeda, Yuzo| Yoshida, Ryuichi| Satoh, Daisuke| Hashimoto, Masaaki| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Abstract | We report 4 cases of surgical resection of metachronous lymph node (LN) metastases from hepatocellular carcinoma (HCC) following hepatectomy. Clinicopathological features and results of LN dissection were investigated in the 4 patients. One patient was found to have a single metastasis in the mediastinal LNs, another had multiple metastases in the mediastinal and abdominal LNs, and the other 2 had single metastases in the abdominal LN. The locations of the abdominal LN metastases were behind the pancreas head in 2 patients and around the abdominal aorta in 1 patient. They all underwent surgical resection of metastatic LNs and had no postoperative complications. The 3 patients whose LN metastases were solitary have been alive for more than 2 years after LN resection, and one of them is free from recurrence. The patient with multiple LN metastases died 13 months after LN resection due to carcinomatosis. With the expectation of long-term survival, a single metachronous LN metastasis from HCC after hepatectomy should be resected in patients without uncontrollable intrahepatic or extrahepatic tumors. |
| Keywords | hepatocellular carcinoma lymph node metastasis hepatectomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-04 |
| Volume | volume66 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 177 |
| End Page | 182 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22525476 |
| Web of Science KeyUT | 000303175300011 |
| JaLCDOI | 10.18926/AMO/48263 |
|---|---|
| FullText URL | 66_2_131.pdf.pdf |
| Author | Jia, Lizhong| Kiryu, Shigeru| Watadani, Takeyuki| Akai, Hiroyuki| Yamashita, Hideomi| Akahane, Masaaki| Ohtomo, Kuni| |
| Abstract | Patients with hepatocellular carcinoma (HCC) complicated by portal vein tumor thrombus (PVTT) have an extremely poor prognosis. It is important to select adequate therapeutic options based on reliable prognostic factors using imaging studies and clinical data. Prognostic factors were analyzed in patients with HCC with PVTT in the first branch or main trunk of the portal vein. From 2000 to 2007, 107 consecutive patients with HCC with PVTT in the major portal vein were reviewed, and diagnostic images and clinical characteristics were retrospectively observed. Thirty-eight possible prognostic factors for survival were analyzed by the log-rank test and multivariate analysis using Coxʼs proportional hazards model. Median overall survival was 14 months following PVTT diagnosis. Survival rates at 6 months, 1, 2, and 3 years were 72.1%, 52.6%, 32.6%, and 29.6%, respectively. Independent prognostic factors for longer survival included:patient age ＜65 years, Child-Pugh classification A/B, PVTT treatment, accumulation of Lipiodol in the PVTT after TACE, initial radical treatment for HCC, HCC located in a single lobe of the liver, and no invasion of HCC to the hepatic vein or bile duct. Survival was associated with liver function, tumor extension, and treatment for HCC and PVTT. |
| Keywords | hepatocellular carcinoma portal vein tumor thrombus prognostic factors |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-04 |
| Volume | volume66 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 131 |
| End Page | 141 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22525471 |
| Web of Science KeyUT | 000303175300006 |
| JaLCDOI | 10.18926/AMO/48262 |
|---|---|
| FullText URL | 66_2_119.pdf.pdf |
| Author | Oka, Hiroaki| Ouchida, Mamoru| Kondo, Takuya| Morita, Fumio| Shimizu, Kenji| |
| Abstract | Human lymphoblastoid TK6 and WTK-1 cells are widely used to detect mutagens in vitro. TK6 cells have wild-type TP53 alleles, while WTK-1 cells have one allele of mutated TP53. Both cells were treated with 5-fluorouracil (5-FU), and gene mutation assay and micronucleus assay were performed to clarify the differential response related to the TP53 gene status. The effects of 5-FU on gene expression were assessed by microarray and quantitative RT-PCR analyses. In WTK-1 cells, 5-FU increased the frequency of cells with micronucleus and mutation. In TK6 cells, frequency of cells with micronucleus was increased but the mutation frequency was not. The cytotoxicity induced by 5-FU was more prominent in TK6 cells than in WTK-1 cells. Analysis of gene expression showed that the genes involved in the TP53 pathway were up-regulated in TK6 cells but not in WTK-1 cells. The differential responses to 5-FU between these cell lines appeared to be due to the difference in the TP53 gene status, thus providing a molecular basis for the bioassays using these cell lines in the toxicology field. Our results indicate that the clinical efficacy of 5-FU chemotherapy may depend on the TP53 genotype. |
| Keywords | 5-fluorouracil TP53 Tk mutation assays microarray analysis |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-04 |
| Volume | volume66 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 119 |
| End Page | 129 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22525470 |
| Web of Science KeyUT | 000303175300005 |
| JaLCDOI | 10.18926/AMO/48258 |
|---|---|
| FullText URL | 66_2_83.pdf.pdf |
| Author | Kuroda, Shinji| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Abstract | Radiotherapy plays a central part in cancer treatment, and use of radiosensitizing agents can greatly enhance this modality. Although studies have shown that several chemotherapeutic agents have the potential to increase the radiosensitivity of tumor cells, investigators have also studied a number of molecularly targeted agents as radiosensitizers in clinical trials based on reasonably promising preclinical data. Recent intense research into the DNA damage-signaling pathway revealed that ataxia-telangiectasia mutated (ATM) and the Mre11-Rad50-NBS1 (MRN) complex play central roles in DNA repair and cell cycle checkpoints and that these molecules are promising targets for radiosensitization. Researchers recently developed three ATM inhibitors (KU-55933, CGK733, and CP466722) and an MRN complex inhibitor (mirin) and showed that they have great potential as radiosensitizers of tumors in preclinical studies. Additionally, we showed that a telomerase-dependent oncolytic adenovirus that we developed (OBP-301 [telomelysin]) produces profound radiosensitizing effects by inhibiting the MRN complex via the adenoviral E1B55kDa protein. A recent Phase I trial in the United States determined that telomelysin was safe and well tolerated in humans, and this agent is about to be tested in combination with radiotherapy in a clinical trial based on intriguing preclinical data demonstrating that telomelysin and ionizing radiation can potentiate each other. In this review, we highlight the great potential of ATM and MRN complex inhibitors, including telomelysin, as radiosensitizing agents. |
| Keywords | ATM (ataxia-telangiectasia mutated) MRN (Mre11-Rad50-NBS1) complex radiosensitization adenovirus E1B55kDa |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2012-04 |
| Volume | volume66 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 83 |
| End Page | 92 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2012 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 22525466 |
| Web of Science KeyUT | 000303175300001 |
| Author | 新納 泉| |
|---|---|
| Published Date | 2012-03-30 |
| Publication Title | 岡山市造山古墳群の調査概報 |
| Content Type | Research Paper |
| Author | 新納 泉| |
|---|---|
| Published Date | 2012-03-30 |
| Publication Title | 岡山市造山古墳群の調査概報 |
| Content Type | Others |
| Author | 岡山大学環境理工学部| |
|---|---|
| Published Date | 2012-03 |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Volume | volume17 |
| Issue | issue1 |
| Content Type | Others |
| Author | 岡山大学環境理工学部| |
|---|---|
| Published Date | 2012-03 |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Volume | volume17 |
| Issue | issue1 |
| Content Type | Others |
| Author | 岡山大学環境理工学部| |
|---|---|
| Published Date | 2012-03 |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Volume | volume17 |
| Issue | issue1 |
| Content Type | Others |
| Author | 岡山大学環境理工学部| |
|---|---|
| Published Date | 2012-03 |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Volume | volume17 |
| Issue | issue1 |
| Content Type | Others |
| Author | 岡山大学環境理工学部| |
|---|---|
| Published Date | 2012-03 |
| Publication Title | 岡山大学環境理工学部研究報告 |
| Volume | volume17 |
| Issue | issue1 |
| Content Type | Others |
