Conditions

close

result 14032 件

JaLCDOI 10.18926/AMO/54601
FullText URL 70_5_401.pdf
Author Kuroda, Shinji| Kikuchi, Satoru| Nishizaki, Masahiko| Kagawa, Shunsuke| Hinotsu, Shiro| Fujiwara, Toshiyoshi|
Abstract Although intermittent pneumatic compression (IPC) has become common as perioperative prophylaxis for venous thromboembolism (VTE) consisting of pulmonary thromboembolism (PE) and deep vein thrombosis (DVT), the prophylactic effect against VTE, especially lethal PE, is not yet satisfactory. Therefore, pharmacologic prophylaxis, such as with enoxaparin, is desirable. While the efficacy and safety of enoxaparin have been proven in several clinical trials, concern about bleeding with longterm (at least 7 days) use have potentially decreased its widespread adoption. We have launched a phase II study to evaluate the efficacy and safety of short-term (3 days) enoxaparin, in which a total of 70 gastric cancer patients undergoing gastrectomy will be recruited, and the primary endpoint is the incidence of DVT. This study could contribute to making pharmacologic prophylaxis for VTE more common.
Keywords venous thromboembolism enoxaparin short-term use gastric cancer surgery
Amo Type Clinical Study Protocols
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 401
End Page 404
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777435
Web of Science KeyUT 000388098700012
JaLCDOI 10.18926/AMO/54600
FullText URL 70_5_397.pdf
Author Akagi, Satoshi| Nakamura, Kazufumi| Akagi, Teiji| Nakagawa, Koji| Takaya, Yoichi| Sarashina, Toshihiro| Ejiri, Kentaro| Ito, Hiroshi|
Abstract A treatment strategy for patients with pulmonary hypertension (PH) and atrial septal defect (ASD) remains unclear. This study was designed to evaluate the effects of initial repair of ASD followed by treatment with PH-specific drugs in patients with PH and ASD. Eligible patients receive transcatheter ASD closure followed by treatment with bosentan and sildenafil. Right heart catheterization is performed at baseline and at 12, 24 and 48 weeks. The primary endpoint is change in pulmonary artery pressure and pulmonary vascular resistance from baseline to follow-up. This study should provide valuable information to establish a therapeutic strategy for PH and ASD.
Keywords pulmonary hypertension atrial septal defect repair and treat transcatheter closure
Amo Type Clinical Study Protocols
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 397
End Page 400
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777434
Web of Science KeyUT 000388098700011
JaLCDOI 10.18926/AMO/54599
FullText URL 70_5_393.pdf
Author Kanaya, Nobuhiko| Aoki, Hideki| Yamasaki, Rie| Morihiro, Toshiaki| Takeuchi, Hitoshi|
Abstract We report a case of a granulocyte colony-stimulating factor (G-CSF)-producing gallbladder tumor associated with fever in a middle-aged female. Preoperative blood analysis showed leukocytosis with elevated levels of C-reactive protein and G-CSF. We resected the liver at S4a+S5, with regional lymph node dissection and partial resection of the duodenum. Histology revealed undifferentiated carcinoma with spindle and giant cells and papillary adenocarcinoma. Immunohistochemistry revealed Stage IIIB G-CSF-producing gallbladder cancer. Postoperatively, leukocyte and serum G-CSF levels decreased to within normal limits. Adjuvant gemcitabine chemotherapy was administered for 16 months, and she has been recurrence-free for 48 months.
Keywords gallbladder cancer G-CSF unidentified fever leukocystosis adenocarcinoma
Amo Type Case Reports
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 393
End Page 396
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777433
Web of Science KeyUT 000388098700010
JaLCDOI 10.18926/AMO/54598
FullText URL 70_5_389.pdf
Author Nishimura, Takeshi| Kohama, Keisuke| Osako, Takaaki| Yamada, Taihei| Tanaka, Hiroyuki| Nakao, Atsunori| Kotani, Joji|
Abstract Advances in critical care medicine have made it possible to sustain vital organ systems in brain-dead patients. One clinical scenario besides donor organ retrieval in which a benefit may be gained from continuing life support is pregnancy. A pregnant woman in her late 30ʼs at 23 weeks gestation exhibiting worsening depression was referred to the Department of Psychiatry. One day after admission she attempted suicide by hanging and suffered a cardiopulmonary arrest. A fetal heart beat and fetal motion was confirmed immediately after resuscitation. Three days after admission, an emergency Cesarean section (CS) was performed because of her unstable hemodynamic situation. The baby was born and the mother died after delivery. The baby presented neurological complications. Such a case should be managed collaboratively among professional experts in several medical teams. Consensus and recommendations for the management of similar scenarios may also be adjusted.
Keywords brain-dead mother suicide somatic support
Amo Type Case Reports
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 389
End Page 392
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777432
Web of Science KeyUT 000388098700009
JaLCDOI 10.18926/AMO/54597
FullText URL 70_5_383.pdf
Author Nishiwaki, Masatake| Hagiya, Hideharu| Kamiya, Toru|
Abstract Kikuchi-Fujimoto disease (KFD) is a benign cause of self-limiting subacute necrotizing lymphadenitis. KFD is rarely complicated with reactive hemophagocytic lymphohistiocytosis (HLH), and the clinical features of the simultaneous occurrence of these conditions are uncertain. A 30-year-old Japanese man with a persistent fever and sore throat presented to our hospital for treatment. Laboratory analysis showed bicytopenia, and radiological studies showed systemic lymphadenopathy accompanied by splenomegaly. A bone marrow examination showed hemophagocytic macrophages, suggesting HLH. Malignant lymphoma was suspected as a possible underlying disease, but the histology of the lymph nodes led to a final diagnosis of KFD and treatment with prednisolone (1 mg/kg/day), resulting in clinical improvement. This case highlighted the importance and difficulty of differentiating KFD from malignant lymphoma as an underlying condition of HLH. The literature review showed that patients with HLH-associated KFD may have higher serum ferritin and lactate dehydrogenase levels compared to typical KFD cases. Definite diagnosis based on pathological examination is essential for a better understanding of this rare disease. The presence of systemic lymphadenopathy does not exclude the possibility of KFD. This case serves to remind physicians that KFD is a potential etiology of HLH.
Keywords hemophagocytic lymphohistiocytosis hemophagocytic syndrome histiocytic necrotizing lymphadenitis Kikuchi disease Kikuchi-Fujimoto disease
Amo Type Case Reports
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 383
End Page 388
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777431
Web of Science KeyUT 000388098700008
JaLCDOI 10.18926/AMO/54596
FullText URL 70_5_377.pdf
Author Kawakami, Yoshio| Katayama, Takashi| Kishida, Masayuki| Oda, Wakako| Inoue, Yasuro|
Abstract A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Direct immunofluorescence showed negative results. Blood culture revealed the growth of gram-negative bacilli. Subsequently, 16S rRNA sequencing of DNA confirmed the organism as Streptobacillus moniliformis, which is the causative pathogen of rat-bite fever. He had frequently encountered wild rats in his house although there was no evidence of rat bite on his body. Empiric therapy with intravenous administration of ceftriaxone in combination with azithromycin hydrate led to a prompt resolution of the symptoms. Precise history-taking related to contact with rats and detection of skin eruptions suggestive of leukocytoclastic vasculitis on the extremities, especially on the feet, can be clues to Streptobacillus moniliformis infection. Familiarity with its cutaneous features is important for early diagnosis; the evidence herein may also help in understanding its underlying pathogenesis.
Keywords livedo vasculitis rat bite fever polyarteritis nodosa septic vasculopathy
Amo Type Case Reports
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 377
End Page 381
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777430
Web of Science KeyUT 000388098700007
JaLCDOI 10.18926/AMO/54595
FullText URL 70_5_371.pdf
Author Noda, Yasuko| Masumizu, Toshiki| Mori, Akitane|
Abstract Methylguanidine (MG) is a known nephrotoxin and neurotoxin, and an intracisternal injection of MG can induce convulsions in experimental animals. In this in vitro study, we examined the inhibitory effects of the antiepileptic agent zonisamide (ZNS) on hydroxyl radicals (•OH) generated from MG by using an electron spin resonance (ESR) technique. ZNS scavenged •OH generated from MG in a dose-dependent manner through direct scavenging during the auto-oxidation of MG. The rate constant of ZNS reacting with the •OH was at a near diffusion-controlled rate. These findings indicate that ZNS might detoxify MG and could thus protect against convulsive disorders.
Keywords methylguanidine zonisamide convulsions hydroxyl radical electron spin resonance
Amo Type Short Communication
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 371
End Page 375
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777429
Web of Science KeyUT 000388098700006
JaLCDOI 10.18926/AMO/54594
FullText URL 70_5_363.pdf
Author Takagi, Kosei| Yagi, Takahito| Yoshida, Ryuichi| Shinoura, Susumu| Umeda, Yuzo| Nobuoka, Daisuke| Kuise, Takashi| Watanabe, Nobuyuki| Fujiwara, Toshiyoshi|
Abstract Sarcopenia following liver surgery has been reported as a predictor of poor prognosis. Here we investigated predictors of outcomes in patients with hepatocellular carcinoma (HCC) and attempted to establish a new comprehensive preoperative assessment protocol. We retrospectively analyzed the cases of 254 patients who underwent curative hepatectomy for HCC with Child-Pugh classification A at our hospital between January 2007 and December 2013. Sarcopenia was evaluated by computed tomography measurement. The influence of sarcopenia on outcomes was evaluated. We used multivariate analyses to assess the impact of prognostic factors associated with outcomes, including sarcopenia. Of the 254 patients, 118 (46.5%) met the criteria for sarcopenia, and 32 had an American Society of Anesthesiologists (ASA) physical status ≥3. The sarcopenic group had a significantly lower 5-year overall survival rate than the non-sarcopenic group (58.2% vs. 82.4% , p=0.0002). In multivariate analyses of prognostic factors, sarcopenia was an independent predictor of poor survival (hazard ratio [HR]=2.28, p=0.002) and poor ASA status (HR=3.17, p=0.001). Sarcopenia and poor ASA status are independent preoperative predictors for poor outcomes after hepatectomy. The preoperative identification of sarcopenia and ASA status might enable the development of comprehensive approaches to assess surgical eligibility.
Keywords sarcopenia American Society of Anesthesiologists physical status hepatectomy hepatocellular carcinoma prognostic factor
Amo Type Original Articles
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 363
End Page 370
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777428
Web of Science KeyUT 000388098700005
JaLCDOI 10.18926/AMO/54593
FullText URL 70_5_353.pdf
Author Katayama, Akihiko| Miyatake, Nobuyuki| Nishi, Hiroyuki| Ujike, Kazuhiro| Hashimoto, Hiroo| Kurato, Risa| Koumoto, Kiichi|
Abstract In a longitudinal study, we examined the link between changes in physical activity and changes in health-related quality of life (HRQOL) in patients on chronic hemodialysis. Seventy-one patients (43 males, 28 females; aged 70.9±10.6 years) on chronic hemodialysis in September 2013 were enrolled. The data of the 43 patients whose complete measurements were taken again in September 2014 were used for the longitudinal analysis. Clinical parameters including age, height, dry weight, duration of hemodialysis, blood pressure (BP), blood triglyceride and HDL cholesterol levels, physical activity, and HRQOL were evaluated. Physical activity was measured by a tri-accelerometer, and HRQOL was evaluated by the EuroQol questionnaire (EQ-5D). In the first cross-sectional analysis, EQ-5D scores were significantly correlated with daily step counts (steps per day) on all days and non-hemodialysis days. In the second longitudinal analysis, in the women, changes in EQ-5D scores were positively correlated with changes in daily step counts on all days. In all patients, changes in EQ-5D were weakly and negatively correlated with changes in physical activity (1-3 METs: min per day) on hemodialysis days. Promoting daily physical activity may improve the HRQOL in patients on chronic hemodialysis, especially in women.
Keywords hemodialysis health related quality of life (HRQOL) physical activity
Amo Type Original Articles
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 353
End Page 361
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777427
Web of Science KeyUT 000388098700004
JaLCDOI 10.18926/AMO/54592
FullText URL 70_5_345.pdf
Author Maruyama, Hidehiko| Nakata, Yusei| Kanazawa, Akane| Kikkawa, Kiyoshi|
Abstract We sought to clarify the survival and neurodevelopmental outcomes of very low birth weight infants (VLBWIs) and to identify risk factors for death or neurodevelopmental impairment (NDI) in VLBWIs at our hospital. The total study population was 217 infants born in 2005-2012 weighing ≤1,500 g. We compared their outcomes with those from previous reports analyzed the causes of death. Risk factors for death after discharge or NDI were evaluated by a multivariate logistic regression analysis. The incidences of death or NDI reported revealed in this study and the database of Neonatal Research Network of Japan were 25.3% and 19.6% (p=0.039), respectively. The main causes of death before discharge were intraventricular hemorrhage, sepsis, and persistent pulmonary hypertension of the newborn. The significant risk factors for death after discharge or NDI were early gestational age (weeks) and periventricular leukomalacia (adjusted odds ratio [95% confidence interval, p-value], 0.72 [0.54-0.94, 0.017] and 6.90 [1.35-38.25, 0.021], respectively). These factors must be addressed in order to improve treatment strategies for VLBWIs.
Keywords intraventricular hemorrhage periventricular leukomalacia persistent pulmonary hypertension of the newborn sepsis very low birth weight infants
Amo Type Original Articles
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 345
End Page 352
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777426
Web of Science KeyUT 000388098700003
JaLCDOI 10.18926/AMO/54591
FullText URL 70_5_339.pdf
Author Miyata, Manabu| Nakahara, Ryuichi| Hamasaki, Ichiro| Hasebe, Satoshi| Furuse, Takashi| Ohtsuki, Hiroshi|
Abstract Although a 0.3 Bangerter filter, which reduces visual acuity, is frequently used for treating moderate amblyopia, the effects on gross stereopsis are not well known. This study quantitatively evaluated whether gross stereopsis is degraded by a Bangerter filter. Seven healthy subjects (median age: 29 years) participated in this psychophysical study. Targets with crossed disparities of 1°, 2°, 3°, 4°, and 5° were randomly presented on a three-dimensional television display. The subjects indicated the point at which the targets popped out from the television screen (matching method). The distance from the screen to the point was defined as the degree of stereopsis. This experiment was performed with and without a 0.3 Bangerter filter. The corrected monocular visual acuities were decreased to about 20/63 by the filter in all subjects. No significant difference was observed for any of the disparities (1°-5°), between the degree of stereopsis visualized with and without filters for either the dominant or the non-dominant eye. The degree of stereopsis was not degraded by the reduced visual acuity induced by the use of 0.3 Bangerter filters. In this regard, the use of 0.3 Bangerter filters may be considered safer than occlusion eye patches for the patients with normal binocular vision.
Keywords amblyopia Bangerter filter binocular vision stereopsis
Amo Type Original Articles
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 339
End Page 344
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777425
Web of Science KeyUT 000388098700002
JaLCDOI 10.18926/AMO/54590
FullText URL 70_5_331.pdf
Author Iida, Atsuyoshi| Nosaka, Nobuyuki| Yumoto, Tetsuya| Knaup, Emily| Naito, Hiromichi| Nishiyama, Chihiro| Yamakawa, Yasuaki| Tsukahara, Kohei| Terado, Michihisa| Sato, Keiji| Ugawa, Toyomu| Nakao, Atsunori|
Abstract In recent years, it has become evident that molecular hydrogen is a particularyl effective treatment for various disease models such as ischemia-reperfusion injury; as a result, research on hydrogen has progressed rapidly. Hydrogen has been shown to be effective not only through intake as a gas, but also as a liquid medication taken orally, intravenously, or locally. Hydrogenʼs effectiveness is thus multifaceted. Herein we review the recent research on hydrogen-rich water, and we examine the possibilities for its clinical application. Now that hydrogen is in the limelight as a gaseous signaling molecule due to its potential ability to inhibit oxidative stress signaling, new research developments are highly anticipated.
Keywords hydrogen antioxidant effect medical gas gaseous signaling molecule clinical tests
Amo Type Review
Publication Title Acta Medica Okayama
Published Date 2016-10
Volume volume70
Issue issue5
Publisher Okayama University Medical School
Start Page 331
End Page 337
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27777424
Web of Science KeyUT 000388098700001
Author Fukuoka, Takanori| Kato, Sadahisa|
Published Date 2016-06-28
Publication Title NOVATECH 2016 Proceedings
Content Type Conference Paper
Author Morita, Ryohei| Gotoh, Kazuma| Fukunishi, Mika| Kubota, Kei| Komaba, Shinichi| Nishimura, Naoto| Yumura, Takashi| Deguchi, Kenzo| Ohki, Shinobu| Shimizue, Tadashi| Ishida, Hiroyuki|
Published Date 2016-07-25
Publication Title Journal of Materials Chemistry A
Volume volume4
Issue issue34
Content Type Journal Article
FullText URL JofAlgebra_459_76.pdf
Author Hashimoto, Mitsuyasu|
Keywords Invariant theory Class group Picard group Krull ring
Note © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license |
Published Date 2016-08-01
Publication Title Journal of Algebra
Volume volume459
Publisher ACADEMIC PRESS INC ELSEVIER SCIENCE
Start Page 76
End Page 108
ISSN 0021-8693
NCID AA00692420
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders http://creativecommons.org/licenses/by-nc-nd/4.0/
File Version author
DOI 10.1016/j.jalgebra.2016.02.025
Web of Science KeyUT 000377319700004
Related Url isVersionOf https://doi.org/10.1016/j.jalgebra.2016.02.025
FullText URL AMV_40_3_527.pdf
Author Hashimoto, Mitsuyasu|
Keywords Group scheme Kleinian singularity Invariant theory
Note The final publication is available at Springer via http://dx.doi.org/10.1007/s40306-015-0145-9|
Published Date 2015-09
Publication Title Acta Mathematica Vietnamica
Volume volume40
Issue issue3
Publisher Springer Singapore
Start Page 527
End Page 534
ISSN 0251-4184
NCID AA00508328
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Institute of Mathematics, Vietnam Academy of Science and Technology (VAST) and Springer Science+Business Media Singapore 2015
File Version author
DOI 10.1007/s40306-015-0145-9
Official Url http://link.springer.com/article/10.1007%2Fs40306-015-0145-9|
FullText URL K0005392_abstract_review.pdf K0005392_fulltext.pdf
Author Ariyoshi, Yuichi|
Published Date 2016-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5392号
Granted Date 2016-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
FullText URL K0005391_abstract_review.pdf K0005391_fulltext.pdf
Author Toma, Kishio|
Published Date 2016-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5391号
Granted Date 2016-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
FullText URL K0005390_abstract_review.pdf K0005390_fulltext.pdf
Author Isozaki, Hideko|
Published Date 2016-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5390号
Granted Date 2016-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English
FullText URL K0005389_abstract_review.pdf K0005389_fulltext.pdf
Author Izushi, Yasuhisa|
Published Date 2016-06-30
Content Type Thesis or Dissertation
Grant Number 甲第5389号
Granted Date 2016-06-30
Thesis Type Doctor of Philosophy in Medical Science
Grantor 岡山大学
language English